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The Q-BONE system: A novel dual-energy X-ray diagnostic method for osteoporosis Q-BONE系统:一种新的双能x线骨质疏松症诊断方法。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-26 DOI: 10.1016/j.jocd.2025.101638
Takahiro Kawamura , Tomoyuki Takahashi , Kayo Okano , Masahiko Yamada , Toshiko Iidaka , Sakae Tanaka , Noriko Yoshimura

Background

Osteoporosis is a prevalent and growing public health issue, particularly in aging populations, due to its association with fragility fractures, reduced mobility, and increased healthcare burden. Dual-energy X-ray absorptiometry (DXA) remains the clinical gold standard for assessing bone mineral density (BMD), but it requires dedicated equipment. DXA is separately required from the radiography system for fracture diagnosis, making DXA difficult to access depending on the facility and region.

Purpose

To address these limitations, we developed the quantitative bone (Q-BONE) system, a novel diagnostic tool that updates existing radiography system to utilize dual energy in a single X-ray irradiation to produce BMD (Q-BONE score) and high-resolution X-ray images (Q-BONE images).

Methods

We evaluated the correlation between the Q-BONE score of Q-BONE system and the BMD of the DXA for the DXA measurement phantom and the 200 people, and the degree of agreement among them by Bland-Altman analysis. Further, fracture detectability was compared between Q-BONE images and radiographs using predefined radiological criteria.

Results

The correlation between bone mineral density and Q-BONE score for 200 individuals was as high as 0.91 with good linearity; however, these two values were statistically inconsistent mainly because of body fat percentage (P < 0.05). Q-BONE images significantly improved visualization of cortical and trabecular bone structures (P < 0.01) and improved detection of fractures and structural abnormalities compared with conventional radiographs.

Conclusions

The Q-BONE system has the potential that achieves comprehensive osteoporosis assessment by combining BMD measurement and fracture evaluation in a single efficient procedure. Its implementation could improve diagnostic efficiency and accessibility, particularly in settings where DXA is unavailable. Further technical improvement on body fat issues, and studies are warranted to assess its clinical utility across broader populations and skeletal sites.
背景:骨质疏松症是一个普遍且日益严重的公共卫生问题,特别是在老龄化人群中,因为它与脆性骨折、活动能力降低和医疗负担增加有关。双能x线吸收仪(DXA)仍然是评估骨矿物质密度(BMD)的临床金标准,但它需要专用设备。骨折诊断需要单独使用DXA,这使得DXA很难根据设施和地区获得。目的:为了解决这些局限性,我们开发了定量骨(Q-BONE)系统,这是一种新的诊断工具,它更新了现有的放射照相系统,利用单次x射线照射的双重能量来产生BMD (Q-BONE评分)和高分辨率x射线图像(Q-BONE图像)。方法:采用Bland-Altman分析方法对200例DXA测量幻影和DXA测量幻影的Q-BONE评分与DXA骨密度的相关性进行评价,并对二者的契合度进行分析。此外,使用预定义的放射学标准比较Q-BONE图像和x线片的骨折可检测性。结果:200例个体骨密度与Q-BONE评分相关性高达0.91,线性良好;然而,这两个值在统计上不一致,主要是因为体脂率(P < 0.05)。与常规x线片相比,Q-BONE图像显著提高了骨皮质和骨小梁结构的可视性(P < 0.01),提高了骨折和结构异常的检出率。结论:Q-BONE系统具有实现综合骨质疏松症评估的潜力,它将骨密度测量和骨折评估结合在一个单一有效的程序中。它的实现可以提高诊断效率和可访问性,特别是在无法使用DXA的环境中。对体脂问题的进一步技术改进和研究是有必要的,以评估其在更广泛的人群和骨骼部位的临床应用。
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引用次数: 0
Comparative diagnostic performance of dual-energy X-ray absorptiometry and other radiological modalities in osteoporosis detection: a systematic review 双能x线吸收仪和其他放射方式在骨质疏松症检测中的比较诊断性能:系统综述。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-26 DOI: 10.1016/j.jocd.2025.101637
Siraj Fahad Wally , Muwaffaq F. Wali , Osama Adnan Hariri , Rasha E. Alotiabi , Badr K Waked , Najla M. Almudayni , Faisal M. Khashab , Batool A. Alshahrani , Khalid M. Aljaaly , Abdulrahman O. Alzahrani
A serious worldwide health issue, osteoporosis is characterized by weakened bones and a higher risk of fracture. Though alternative imaging modalities like quantitative ultrasound (QUS), radiographic absorptiometry (RA), quantitative computed tomography (QCT), and radiofrequency echographic multispectrometry (REMS) have emerged as viable diagnostic or screening tools, dual-energy X-ray absorptiometry (DEXA) is still the gold standard for measuring bone mineral density (BMD). The purpose of this systematic review was to evaluate the clinical usefulness, diagnostic accuracy, and dependability of different radiographic modalities for osteoporosis detection. In order to find papers published between 2001 and 2023 comparing DEXA with other radiographic modalities for osteoporosis diagnosis, a thorough search of the PubMed, Scopus, and ScienceDirect databases was undertaken. There were ten studies that qualified. Study design, demographic characteristics, imaging methods, diagnostic thresholds, and performance metrics (sensitivity, specificity, and correlation coefficients) were among the data that were extracted. Across studies, DEXA consistently demonstrated high precision and strong correlation with fracture risk, confirming its role as the reference standard. QUS showed moderate agreement with DEXA, supporting its use as a screening tool but not for diagnostic confirmation. RA provided good reproducibility but lower sensitivity compared with DEXA. QCT exhibited superior sensitivity (up to 91%) and early trabecular bone detection but was limited by higher cost and radiation exposure. Emerging evidence for REMS demonstrated strong correlation with DEXA (r = 0.85–0.90), comparable diagnostic accuracy, and the advantage of being radiation-free and portable. DEXA remains the gold standard for osteoporosis diagnosis; however, QCT and REMS show promising diagnostic accuracy and may complement DEXA for early detection and longitudinal monitoring. QUS and RA can serve as cost-effective screening tools, particularly in settings where DEXA is unavailable. Further large-scale, prospective studies with standardized diagnostic thresholds are needed to validate these findings and optimize imaging strategies for osteoporosis management.
骨质疏松症是一个严重的全球性健康问题,其特点是骨骼变弱和骨折风险较高。虽然定量超声(QUS)、放射吸收仪(RA)、定量计算机断层扫描(QCT)和射频超声多光谱法(REMS)等替代成像方式已经成为可行的诊断或筛查工具,但双能x射线吸收仪(DEXA)仍然是测量骨矿物质密度(BMD)的金标准。本系统综述的目的是评估骨质疏松症不同影像学检查的临床有效性、诊断准确性和可靠性。为了找到2001年至2023年间发表的比较DEXA与其他骨质疏松症放射诊断方式的论文,我们对PubMed、Scopus和ScienceDirect数据库进行了全面的搜索。有10项研究符合条件。提取的数据包括研究设计、人口统计学特征、成像方法、诊断阈值和性能指标(敏感性、特异性和相关系数)。在所有研究中,DEXA始终表现出高精度和与骨折风险的强相关性,证实了其作为参考标准的作用。QUS与DEXA表现出中度一致,支持其作为筛查工具,但不用于诊断确认。RA重复性好,但灵敏度较DEXA低。QCT表现出更高的灵敏度(高达91%)和早期小梁骨检测,但受到较高成本和辐射暴露的限制。新出现的证据表明REMS与DEXA (r = 0.85-0.90)、相当的诊断准确性以及无辐射和便携的优势有很强的相关性。DEXA仍然是骨质疏松症诊断的金标准;然而,QCT和REMS显示出有希望的诊断准确性,可以补充DEXA进行早期检测和纵向监测。QUS和RA可以作为具有成本效益的筛查工具,特别是在没有DEXA的情况下。需要进一步的大规模、具有标准化诊断阈值的前瞻性研究来验证这些发现,并优化骨质疏松症管理的影像学策略。
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引用次数: 0
Bone density, structure, and estimated strength in children with congenital heart disease. A CHAMPS* cohort study 先天性心脏病儿童的骨密度、结构和估计强度。一项champ *队列研究。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-25 DOI: 10.1016/j.jocd.2025.101636
Marta C. Erlandson , Matthew S. Chapelski , Chantelle L. Baril , Charissa Pockett , Scott Pharis , Kristi D. Wright , Corey R. Tomczak
Introduction: Children with congenital heart disease (CHD) have lower levels of physical activity, lower birth weights, and lower nutrient intake compared to their typically developing peers (TDP); which can put children with CHD at increased risk of impaired skeletal development. Therefore, the purpose of this study was to assess the bone architecture of children with CHD compared to TDP. Our secondary objective was to evaluate differences between CHD lesion complexity.
Methods: Forty-two children with CHD 7 to 15 years of age (10.9±2.5) were age and sex-matched to 41 TDP. Peripheral quantitative computed tomography (pQCT) scans were obtained at the distal (4%) and shaft (65%, 66%) sites for the radius and tibia, respectively. pQCT bone parameters were compared between groups using multiple analysis of covariance (MANCOVA), using sex, age, height, weight, maturity, and physical activity as covariates.
Results: There were no significant differences between children with CHD and TDP at the distal radius or distal tibia (p>0.05). Children with CHD had significantly lower total area, cortical content, cortical area, cortical thickness, and polar stress-strain index at the radial and tibial shaft compared to TDP (p<0.05). When sub-dividing children with CHD by lesion severity, the complex CHD group had significantly lower cortical content, cortical area, cortical thickness, and polar stress-strain index at the radius and tibia shaft when compared to TDP (p<0.05). Additionally, children with complex lesions had greater cortical density at the radius and tibia shaft when compared to TDP (p<0.05). Finally, children with simple lesions had greater cortical density at the radius shaft when compared to TDP (p<0.05).
Conclusion: Children with complex CHD had worse bone parameters when compared to TDP. Children with complex CHD lesions may be at increased risk of impaired bone density, structure, and estimated strength at both the radius and tibia shaft.
与正常发育的同龄人(TDP)相比,患有先天性心脏病(CHD)的儿童身体活动水平较低,出生体重较低,营养摄入量较低;这会增加患有冠心病的儿童骨骼发育受损的风险。因此,本研究的目的是评估与TDP相比,CHD儿童的骨结构。我们的次要目的是评估冠心病病变复杂性的差异。方法:7 ~ 15岁(10.9±2.5)例冠心病患儿42例,年龄、性别匹配41例。周围定量计算机断层扫描(pQCT)分别在桡骨和胫骨的远端(4%)和轴端(65%,66%)进行扫描。采用多元协方差分析(MANCOVA),以性别、年龄、身高、体重、成熟度和体力活动为协变量,比较各组间pQCT骨骼参数。结果:冠心病患儿桡骨远端和胫骨远端TDP差异无统计学意义(p < 0.05)。与TDP相比,冠心病患儿桡骨和胫骨干的总面积、皮质含量、皮质面积、皮质厚度和极性应力-应变指数均显著降低(p)。结论:复杂型冠心病患儿的骨参数较TDP差。患有复杂冠心病病变的儿童在桡骨和胫骨干的骨密度、结构和估计强度受损的风险可能会增加。
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引用次数: 0
Adherence and persistence of daily and twice-weekly teriparatide treatment in postmenopausal women with high-risk of fracture 绝经后骨折高危妇女每日和每周两次特立帕肽治疗的依从性和持久性。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-24 DOI: 10.1016/j.jocd.2025.101641
Takeshi Mochizuki , Koichiro Yano , Katsunori Ikari , Ken Okazaki
Background: This study aimed to determine the differences in adherence and persistence between a daily and twice-weekly teriparatide regimens in postmenopausal women at high risk of fracture.
Methods: Ninety-eight postmenopausal women diagnosed with a high risk for fractures were enrolled and randomized into two groups to receive daily (D-TPTD) or twice-weekly (TW-TPTD) teriparatide. Adherence, measured using the medication possession ratio (MPR), and persistence were measured for both groups. MPR was calculated as the number of days the patient was actually covered by the administered medication divided by the number of days of the study period, which was theoretically 24 months.
Results: The persistence rates at 24 months in the d-TPTD and TW-TPTD groups were 66.7 % and 59.6 %, respectively, with no significant difference between the two. Additionally, adherence and persistence in patients without vertebral fracture at baseline were lower than those with vertebral fracture. In the Cox proportional hazards analysis, treatment persistence in patients without vertebral fracture was lower than that in patients with vertebral fracture (p = 0.027; hazard ratio, 0.369; 95 % confidence intervals, 0.15–0.89).
Conclusion: There was no difference in adherence and persistence between the two groups at 24 months after treatment initiation. High adherence and retention to teriparatide can be expected in postmenopausal women at a high risk of vertebral fractures.
背景:本研究旨在确定绝经后骨折高风险妇女每日服用特立帕肽和每周服用两次特立帕肽方案的依从性和持久性的差异。方法:入选98名确诊为骨折高危的绝经后妇女,随机分为每日(D-TPTD)和每周(TW-TPTD)两次特立帕肽两组。使用药物占有比(MPR)测量依从性,并测量两组的持久性。MPR的计算方法是患者实际接受药物治疗的天数除以研究周期的天数,理论上为24个月。结果:d-TPTD组和TW-TPTD组24个月的持续率分别为66.7%和59.6%,两者差异无统计学意义。此外,基线时无椎体骨折患者的依从性和持久性低于有椎体骨折患者。在Cox比例风险分析中,无椎体骨折患者的治疗坚持度低于有椎体骨折患者(p = 0.027;风险比0.369;95%可信区间0.15-0.89)。结论:治疗开始后24个月,两组患者的依从性和持久性无差异。绝经后椎体骨折高风险的妇女对特立帕肽的高依从性和保留性是可以预期的。
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引用次数: 0
Correlation between body mass index, bone mineral density and trabecular bone score in patients with Type 2 diabetes 2型糖尿病患者体重指数、骨密度与骨小梁评分的相关性
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-22 DOI: 10.1016/j.jocd.2025.101640
Lili Zhuang , Song Zou
Objective: To investigate the relationship between body mass index (BMI) and areal bone mineral density (BMD) as well as trabecular bone score (TBS) in adults with type 2 diabetes mellitus (T2DM) and to determine whether age or sex modifies these relationships.
Methods: We retrospectively identified 762 community-dwelling adults aged ≥ 50 years (257 with T2DM and 505 non-diabetic controls) who underwent dual-energy X-ray absorptiometry at our centre between August 2023 and May 2024. Lumbar-spine and femoral-neck BMD as well as TBS were extracted. Associations were evaluated with Spearman’s ρ and multiple linear regression, adjusting for age and sex.
Results: In men, BMI, BMD and TBS did not differ between diabetic and non-diabetic participants in any age stratum (all P > 0.05). Women aged 50–60 y with T2DM exhibited higher LS-BMD but lower TBS than non-diabetic peers (both P < 0.05), indicating early dissociation between density and micro-architecture. Correlation analysis shows a positive association between BMI and LS-BMD (ρ=0.286, P= 0.002). Multivariate linear regression confirmed that BMI was an independent positive predictor of LS-BMD (β = 0.276, P < 0.001) and an independent negative predictor of TBS (β = −0.069, P = 0.043).
Conclusion: In T2DM, higher BMI is independently associated with greater BMD but poorer trabecular micro-architecture. This paradox is most evident in post-menopausal women, underscoring TBS as an early warning tool when BMD remains normal.
目的:探讨成人2型糖尿病(T2DM)患者身体质量指数(BMI)与骨密度(BMD)及骨小梁评分(TBS)的关系,并探讨年龄和性别是否会改变这种关系。方法:我们回顾性地确定了762名年龄≥50岁的社区居民(257名T2DM患者,505名非糖尿病对照组),他们于2023年8月至2024年5月在我们的中心接受了双能x线吸收仪检查。提取腰椎、股骨颈骨密度及TBS。采用Spearman ρ和多元线性回归评估相关性,调整年龄和性别。结果:在男性中,糖尿病和非糖尿病参与者在任何年龄段的BMI、BMD和TBS均无差异(均P >; 0.05)。50-60岁的女性T2DM患者的LS-BMD高于非糖尿病患者,但TBS低于非糖尿病患者(P < 0.05),表明密度与微结构之间的早期分离。相关分析显示BMI与LS-BMD呈正相关(ρ=0.286, P= 0.002)。多元线性回归证实BMI是LS-BMD的独立阳性预测因子(β = 0.276, P < 0.001),是TBS的独立阴性预测因子(β = - 0.069, P = 0.043)。结论:在T2DM中,较高的BMI与较高的BMD和较差的小梁微结构独立相关。这种矛盾在绝经后妇女中最为明显,强调TBS是骨密度保持正常的早期预警工具。
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引用次数: 0
Mobile home exercise application accelerating bone mineral density among postmenopausal osteoporosis Japanese women with bazedoxifene: An open-label, non-randomized, pilot study 移动家庭运动应用加速绝经后骨质疏松症日本妇女使用巴泽多昔芬的骨密度:一项开放标签,非随机,试点研究。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-22 DOI: 10.1016/j.jocd.2025.101639
Yohei Yamamoto , Daisuk Inoue , Reiko Inoue , Kazuhide Inage , Yasuaki Murata , Tomonori Shigemura , Miki Morimoto , Kenta Kono , Yusuke Rokuta
Objectives: This study developed a home exercise application, LongLifeSupport, which provides basic daily exercise videos and an automatic recording calendar. Exercise plays an important role in bone health, as it positively influences bone mineral density (BMD). However, its effects on drug treatment remain unclear. This pilot study aimed to determine the effects of exercise on BMD, quality of life (QOL), and physical function among patients with osteoporosis.
Methods: Fifty patients with untreated osteoporosis were included, non-randomized, and equally divided into two groups: the application group or the pamphlet group. Both groups started bazedoxifene treatment and exercised for 52 weeks. At 24 and 52 weeks, we assessed BMD (lumbar spine, femoral neck, and total hip), serum parameters, EuroQol five dimensions (EQ-5D), short physical performance battery score, and short test battery score for locomotive syndrome.
Results: At 52 weeks, the percentage changes from baseline in femoral neck and total hip BMD (5.6% and 2.5%, respectively) were significantly greater in the application group than in the pamphlet group (2.1% and 1.0%, respectively). The application group revealed a significantly higher adherence rate (70.8%) compared to the pamphlet group (52.2%) and significant improvements between baseline and 52 weeks in the EQ-5D visual analog scale, two-step test (stage and value) using a short test battery for locomotive syndrome, and chair stand seconds of the short physical performance battery.
Conclusions: Home exercise with bazedoxifene significantly improved BMD, QOL, and physical ability compared to pamphlets. Hence, this application provides an effective exercise program and may be utilized for elderly women with osteoporosis.
目的:本研究开发了一个家庭运动应用程序,LongLifeSupport,它提供基本的日常运动视频和自动记录日历。运动对骨骼健康起着重要的作用,因为它对骨密度(BMD)有积极的影响。然而,它对药物治疗的影响尚不清楚。本初步研究旨在确定运动对骨质疏松症患者骨密度、生活质量(QOL)和身体功能的影响。方法:纳入50例未经治疗的骨质疏松症患者,非随机,平均分为两组:应用组和宣传册组。两组均开始巴泽多昔芬治疗并运动52周。在24周和52周时,我们评估了BMD(腰椎、股骨颈和全髋关节)、血清参数、EuroQol 5个维度(EQ-5D)、短时物理性能电池评分和机车综合征的短时测试电池评分。结果:在52周时,应用组股骨颈和全髋关节骨密度较基线变化的百分比(分别为5.6%和2.5%)明显大于小册子组(分别为2.1%和1.0%)。与小册子组(52.2%)相比,应用组的依从率(70.8%)显着高于小册子组(52.2%),并且在基线和52周之间,EQ-5D视觉模拟量表,使用机车综合征短测试电池的两步测试(阶段和值)以及短物理性能电池的椅子站立秒均有显着改善。结论:与宣传单相比,使用贝泽多昔芬进行家庭运动可显著改善骨密度、生活质量和体能。因此,本应用程序提供了一个有效的锻炼计划,可用于老年妇女骨质疏松症。
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引用次数: 0
Low Bone Mass is Common and Associated with Delayed Estrogen Replacement Therapy in Adult Brazilian Women with Turner Syndrome 低骨量是常见的,并与延迟雌激素替代治疗的成年巴西妇女特纳综合征
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-15 DOI: 10.1016/j.jocd.2025.101635
Carla Antoniana Ferreira de Almeida Vieira , Eveline Gadelha Pereira Fontenele , Danielle de Souza Bessa , Fábia Karine de Moura Lopes , Larissa Luna Queiroz , Carlos Henrique Paiva Grangeiro , Catarina Brasil D´alva , Renan Magalhães Montenegro Junior , Maria Elisabete Amaral de Moraes
Introduction: Turner syndrome is a rare chromosomal abnormality in females who typically present with short stature, hypogonadism and increased risk of osteoporosis. Areal bone densitometry (aBMD) usually underestimates bone mass in people with short stature and the bone mineral apparent density (BMAD) can be used as an adjustment for height. The study aimed to assess the frequency of low bone mass and associated factors in Brazilian women with TS at a referral center.
Methodology: Cross-sectional dual-energy X-ray absorptiometry scans at the lumbar spine and femur were performed to assess bone mass. The association of aBMD, BMAD, age, height, history of fractures, karyotype, use of somatropin (rhGH) and estrogen replacement therapy (ERT) with low bone mass was tested and p-value < 0.05 was considered statistically significant.
Results: Forty-six patients with a mean age of 32 years and height (SDS) 145 cm (-2.89) were evaluated. Five (11%) had a history of fracture. Thirty-five (83%) patients had delayed puberty (> 13 years), 4 (9%) had spontaneous menarche, 19 (41%) were treated with rhGH. Lumbar aBMD was positively correlated to height (p = 0.010). Low bone mass was more frequently detected with aBMD (49% lumbar spine and 48% femoral neck) than with BMAD (31% lumbar spine and 13% femoral neck) and was associated with estrogen status (p=0,002). All patients with delayed puberty and without ERT at the time of the study had low bone mass at the lumbar spine. In contrast, all patients with spontaneous menarche had normal bone mass at both sites. No significant correlation between treatment with rhGH or karyotype with low bone mass was observed.
Conclusions: Low bone mass is a common finding in a cohort of Brazilian women with TS and is associated with delayed puberal induction or start of ERT. Our results highlight the importance of early diagnosis and prompt initiation of ERT to optimise bone mass acquisition.
特纳综合征是一种罕见的女性染色体异常,通常表现为身材矮小,性腺功能减退和骨质疏松症的风险增加。面骨密度(aBMD)通常低估了矮小人群的骨量,而骨矿物质表观密度(BMAD)可以用来调节身高。该研究旨在评估转诊中心的巴西TS女性低骨量发生率及相关因素。方法:在腰椎和股骨处进行横断面双能x线吸收仪扫描以评估骨量。检测aBMD、BMAD、年龄、身高、骨折史、核型、使用生长激素(rhGH)和雌激素替代疗法(ERT)与低骨量的相关性,p值<; 0.05认为有统计学意义。结果:46例患者平均年龄32岁,身高145 cm(-2.89)。5例(11%)有骨折史。35例(83%)患者青春期延迟(13年),4例(9%)患者自发性月经初潮,19例(41%)患者接受了rhGH治疗。腰aBMD与身高呈正相关(p = 0.010)。aBMD(49%的腰椎和48%的股骨颈)比BMAD(31%的腰椎和13%的股骨颈)更常检测到低骨量,并且与雌激素水平相关(p= 0.002)。在研究时,所有青春期延迟且没有ERT的患者腰椎骨量都很低。相比之下,所有自发月经初潮的患者在两个部位的骨量正常。rhGH治疗与低骨量核型之间无显著相关性。结论:低骨量在巴西女性TS队列中是一个常见的发现,并且与青春期诱导延迟或ERT开始有关。我们的研究结果强调了早期诊断和及时启动ERT以优化骨量获取的重要性。
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引用次数: 0
Three-Dimensional Bone Structural Analysis in Postmenopausal Patients With Rheumatoid Arthritis With and Without Bone Erosion 绝经后类风湿关节炎伴和不伴骨侵蚀患者的三维骨结构分析。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-01 DOI: 10.1016/j.jocd.2025.101631
Yong Jun Choi , Ji-Won Kim , Ju-Yang Jung , Chang-Hee Suh , Yoon-Sok Chung , Hyoun-Ah Kim
Introduction: This study compared the three-dimensional (3D) bone structure based on bone erosion in postmenopausal patients with rheumatoid arthritis (RA) using a novel dual-energy X-ray absorptiometry (DXA)-based 3D analysis tool.
Methods: In this cross-sectional study, 171 postmenopausal women with RA (aged ≥ 50 years) were categorized based on bone erosions on hand and foot X-rays. We conducted 3D bone structure analyses on DXA hip scans using 3D-Shaper software, measuring volumetric BMD of integral (IvBMD), trabecular (TvBMD), and cortical (CvBMD) compartments.
Results: The study included 94 patients without erosion and 77 with erosion. The erosion-positive group showed significantly lower femoral neck (FN) parameters: areal BMD (0.722 ± 0.090 vs. 0.756 ± 0.102 g/cm², p = 0.023), IvBMD (269.784 ± 49.306 vs. 288.610 ± 59.220 mg/cm³, p = 0.027), TvBMD (157.043 ± 39.154 vs. 170.787 ± 45.168 mg/cm³, p = 0.037), and CvBMD (709.563 ± 68.028 vs. 735.182 ± 81.470 mg/cm³, p = 0.026). Multiple regression analysis revealed that disease activity score (DAS28) was independently associated with FN CvBMD (β = -24.693, p = 0.023).
Conclusions: This study demonstrated that bone erosion in RA is associated with significant alterations in bone structure, particularly in the FN region. Disease activity primarily affects cortical bone, highlighting the need for stringent disease management to maintain bone health in patients with RA.
摘要:本研究采用一种新型双能x线吸收仪(DXA)为基础的三维分析工具,比较绝经后类风湿关节炎(RA)患者骨侵蚀的三维(3D)骨结构。方法:在这项横断面研究中,171名绝经后RA患者(年龄≥50岁)根据手部和足部x光片的骨侵蚀情况进行分类。我们使用3D- shaper软件对DXA髋关节扫描进行了三维骨结构分析,测量了整体(IvBMD)、小梁(TvBMD)和皮质(CvBMD)隔室的体积骨密度。结果:无糜烂患者94例,糜烂患者77例。侵蚀阳性组股骨颈FN参数显著降低:面积骨密度(0.722±0.090比0.756±0.102 g/cm²,p = 0.023)、IvBMD(269.784±49.306比288.610±59.220 mg/cm³,p = 0.027)、TvBMD(157.043±39.154比170.787±45.168 mg/cm³,p = 0.037)、CvBMD(709.563±68.028比735.182±81.470 mg/cm³,p = 0.026)。多元回归分析显示,疾病活动评分(DAS28)与FN CvBMD独立相关(β = -24.693, p = 0.023)。结论:本研究表明,RA的骨侵蚀与骨结构的显著改变有关,特别是在FN区域。疾病活动主要影响皮质骨,强调需要严格的疾病管理来维持RA患者的骨骼健康。
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引用次数: 0
How accurate are Dual-Energy X-Ray Absorptiometry measurements in clinical practice?: a retrospective single centre study. 在临床实践中,双能x射线吸收仪测量的准确性如何?回顾性单中心研究。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-01 Epub Date: 2025-07-04 DOI: 10.1016/j.jocd.2025.101606
Yunus Burak Bayır, Zeynep Kıraç Ünal, Zeynep Alpoğuz Yılmaz, Bengü Türemenoğulları, Ömer Ata, Emre Adıgüzel

Objective: The aim of this study was to identify common errors in DXA measurements at our hospital, establish standardization, and contribute to operator training.

Design: This descriptive study at a single centre analyzed 2375 spine and femur DXA images for errors. The reports were reviewed according to a checklist prepared considering The International Society for Clinical Densitometry(ISCD) official positions. Each image was reviewed by a Radiologist and Physical Medicine and Rehabilitation (PMR) specialist trained in the principles and standards of DXA scanning prior to the study. All the assessments were double-checked by other specialists and any incorrect images were reported. All the scans taken and available during the observation period were reviewed. The study included scan images taken in our centre, including lumbar spine and proximal femur measurements, for which all information was entered correctly and completely. Forearm measurements, whole-body measurements, or measurements performed in children were excluded.

Results: A total of 2375 DXA scan results from a single centre were analyzed. According to the evaluation criteria, 1023 (43.1%) lumbar spine and 1078 (45.4%) proximal femur DXA scans had at least one error. The most common error encountered was the presence of excessive degeneration (31.0%) for lumbar spine results, and inadequate hip internal rotation (23.9%) in the proximal femur results. There were found to be more errors in lumbar measurements according to BMI (p=0.04) and age (p≤0.001), and errors in the femur were higher in male gender (p<0.001).

Conclusions: Although the operator and auto-interpretation error rates in this study were low compared to the literature, the results showed that standardization in operator training is not at the desired level. It is hoped that this study will raise awareness of clinicians about DXA imaging errors, and that the training of clinicians who interpret DXA results should be considered as important as the training of technicians.

目的:本研究的目的是识别我院DXA测量中的常见错误,建立标准化,并有助于操作人员培训。设计:本描述性研究在单一中心分析了2375张脊柱和股骨DXA图像的错误。根据考虑到国际临床密度测定学会(ISCD)官方立场而准备的检查表对报告进行了审查。每张图像都由接受过DXA扫描原则和标准培训的放射科医生和物理医学和康复(PMR)专家在研究前进行审查。所有的评估都由其他专家进行复查,并报告任何不正确的图像。对观察期间所作和可用的所有扫描进行了审查。该研究包括在我们中心拍摄的扫描图像,包括腰椎和股骨近端测量,所有信息输入正确完整。前臂测量、全身测量或儿童测量均被排除在外。结果:分析了来自单个中心的2375个DXA扫描结果。根据评估标准,1023例(43.1%)腰椎和1078例(45.4%)股骨近端DXA扫描至少有一次错误。最常见的错误是腰椎结果出现过度退变(31.0%),股骨近端结果出现髋关节内旋不足(23.9%)。研究发现,BMI (p=0.04)和年龄(p≤0.001)对腰椎测量的误差更多,男性对股骨测量的误差更高(p结论:尽管本研究中操作人员和自动翻译的错误率与文献相比较低,但结果表明操作人员培训的标准化程度未达到预期水平。希望本研究能够提高临床医生对DXA成像错误的认识,并且对解释DXA结果的临床医生的培训应该与技术人员的培训一样重要。
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引用次数: 0
Radiation therapy–Associated bone attenuation loss in anorectal cancer:Need for standardized imaging and clinical correlation 放射治疗相关的肛肠癌骨衰减损失:需要标准化的影像学和临床相关性。
IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2025-10-01 DOI: 10.1016/j.jocd.2025.101629
Dr. Parth Aphale, Himanshu Shekhar, Shashank Dokania
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引用次数: 0
期刊
Journal of Clinical Densitometry
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