Journal of Clinical Densitometry最新文献_第2页

Mobile home exercise application accelerating bone mineral density among postmenopausal osteoporosis Japanese women with bazedoxifene: An open-label, non-randomized, pilot study 移动家庭运动应用加速绝经后骨质疏松症日本妇女使用巴泽多昔芬的骨密度：一项开放标签，非随机，试点研究。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-10-22 DOI: 10.1016/j.jocd.2025.101639

Yohei Yamamoto , Daisuk Inoue , Reiko Inoue , Kazuhide Inage , Yasuaki Murata , Tomonori Shigemura , Miki Morimoto , Kenta Kono , Yusuke Rokuta

Objectives: This study developed a home exercise application, LongLifeSupport, which provides basic daily exercise videos and an automatic recording calendar. Exercise plays an important role in bone health, as it positively influences bone mineral density (BMD). However, its effects on drug treatment remain unclear. This pilot study aimed to determine the effects of exercise on BMD, quality of life (QOL), and physical function among patients with osteoporosis.

Methods: Fifty patients with untreated osteoporosis were included, non-randomized, and equally divided into two groups: the application group or the pamphlet group. Both groups started bazedoxifene treatment and exercised for 52 weeks. At 24 and 52 weeks, we assessed BMD (lumbar spine, femoral neck, and total hip), serum parameters, EuroQol five dimensions (EQ-5D), short physical performance battery score, and short test battery score for locomotive syndrome.

Results: At 52 weeks, the percentage changes from baseline in femoral neck and total hip BMD (5.6% and 2.5%, respectively) were significantly greater in the application group than in the pamphlet group (2.1% and 1.0%, respectively). The application group revealed a significantly higher adherence rate (70.8%) compared to the pamphlet group (52.2%) and significant improvements between baseline and 52 weeks in the EQ-5D visual analog scale, two-step test (stage and value) using a short test battery for locomotive syndrome, and chair stand seconds of the short physical performance battery.

Conclusions: Home exercise with bazedoxifene significantly improved BMD, QOL, and physical ability compared to pamphlets. Hence, this application provides an effective exercise program and may be utilized for elderly women with osteoporosis.

目的：本研究开发了一个家庭运动应用程序，LongLifeSupport，它提供基本的日常运动视频和自动记录日历。运动对骨骼健康起着重要的作用，因为它对骨密度（BMD）有积极的影响。然而，它对药物治疗的影响尚不清楚。本初步研究旨在确定运动对骨质疏松症患者骨密度、生活质量（QOL）和身体功能的影响。方法：纳入50例未经治疗的骨质疏松症患者，非随机，平均分为两组：应用组和宣传册组。两组均开始巴泽多昔芬治疗并运动52周。在24周和52周时，我们评估了BMD（腰椎、股骨颈和全髋关节）、血清参数、EuroQol 5个维度（EQ-5D）、短时物理性能电池评分和机车综合征的短时测试电池评分。结果：在52周时，应用组股骨颈和全髋关节骨密度较基线变化的百分比（分别为5.6%和2.5%）明显大于小册子组（分别为2.1%和1.0%）。与小册子组（52.2%）相比，应用组的依从率（70.8%）显着高于小册子组（52.2%），并且在基线和52周之间，EQ-5D视觉模拟量表，使用机车综合征短测试电池的两步测试（阶段和值）以及短物理性能电池的椅子站立秒均有显着改善。结论：与宣传单相比，使用贝泽多昔芬进行家庭运动可显著改善骨密度、生活质量和体能。因此，本应用程序提供了一个有效的锻炼计划，可用于老年妇女骨质疏松症。

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引用次数: 0

Adherence and persistence of daily and twice-weekly teriparatide treatment in postmenopausal women with high-risk of fracture 绝经后骨折高危妇女每日和每周两次特立帕肽治疗的依从性和持久性。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-10-24 DOI: 10.1016/j.jocd.2025.101641

Takeshi Mochizuki , Koichiro Yano , Katsunori Ikari , Ken Okazaki

Background: This study aimed to determine the differences in adherence and persistence between a daily and twice-weekly teriparatide regimens in postmenopausal women at high risk of fracture.

Methods: Ninety-eight postmenopausal women diagnosed with a high risk for fractures were enrolled and randomized into two groups to receive daily (D-TPTD) or twice-weekly (TW-TPTD) teriparatide. Adherence, measured using the medication possession ratio (MPR), and persistence were measured for both groups. MPR was calculated as the number of days the patient was actually covered by the administered medication divided by the number of days of the study period, which was theoretically 24 months.

Results: The persistence rates at 24 months in the d-TPTD and TW-TPTD groups were 66.7 % and 59.6 %, respectively, with no significant difference between the two. Additionally, adherence and persistence in patients without vertebral fracture at baseline were lower than those with vertebral fracture. In the Cox proportional hazards analysis, treatment persistence in patients without vertebral fracture was lower than that in patients with vertebral fracture (p = 0.027; hazard ratio, 0.369; 95 % confidence intervals, 0.15–0.89).

Conclusion: There was no difference in adherence and persistence between the two groups at 24 months after treatment initiation. High adherence and retention to teriparatide can be expected in postmenopausal women at a high risk of vertebral fractures.

背景：本研究旨在确定绝经后骨折高风险妇女每日服用特立帕肽和每周服用两次特立帕肽方案的依从性和持久性的差异。方法：入选98名确诊为骨折高危的绝经后妇女，随机分为每日（D-TPTD）和每周（TW-TPTD）两次特立帕肽两组。使用药物占有比（MPR）测量依从性，并测量两组的持久性。MPR的计算方法是患者实际接受药物治疗的天数除以研究周期的天数，理论上为24个月。结果：d-TPTD组和TW-TPTD组24个月的持续率分别为66.7%和59.6%，两者差异无统计学意义。此外，基线时无椎体骨折患者的依从性和持久性低于有椎体骨折患者。在Cox比例风险分析中，无椎体骨折患者的治疗坚持度低于有椎体骨折患者（p = 0.027；风险比0.369；95%可信区间0.15-0.89）。结论：治疗开始后24个月，两组患者的依从性和持久性无差异。绝经后椎体骨折高风险的妇女对特立帕肽的高依从性和保留性是可以预期的。

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引用次数: 0

Reference data for peripheral quantitative computed tomography for assessment of bone geometry and strength in Indian children and youth 周边定量计算机断层扫描评估印度儿童和青少年骨骼几何形状和强度的参考数据

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-12-31 DOI: 10.1016/j.jocd.2025.101665

Anuradha Khadilkar , Chirantap Oza , Neha Kajale , Vaman Khadilkar , Alex Ireland , Dipali Ladkat , Vivek Patwardhan , Raja Padidela , M. Zulf Mughal

Introduction: Currently, there is a paucity of data for bone geometry and strength parameters for Indian children. This is essential because of differences in stature, body composition, and bone outcomes between Indian children and Western populations on which existing reference data are based. As dual energy X-ray absorptiometry is size dependent, we conducted the present study with the objective of generating age and sex-specific reference centile curves for peripheral quantitative computed tomography (pQCT) for Indian children and adolescents.

Methods: A cross-sectional, observational study was conducted from November 2017 to July 2022 on 961 (501 boys) healthy children aged 8 to 18 years from Pune, India. The XCT-2000 pQCT scanner (Stratec Inc, GmbH, Pforzheim, Germany) was used to measure volumetric trabecular density at 4 % site and volumetric cortical density, polar stress-strain index, cortical thickness, and muscle area at 66 % site of left radius.

Results: We have presented percentile curves for total, trabecular, and cortical density for age, as well as cortical area and cortical thickness for height. A maximum increase in total volumetric density to the preceding age group of 10.7 % was observed in boys at the age of 17 years, whereas a maximum increase of 8 % was observed in girls at the age of 15 years. Average increase in trabecular density was 0.2 % per year. Cortical density was significantly higher in girls (8.7 %) from the age of 13 years as compared to boys. Cortical thickness was significantly higher in girls (13.3 %) as compared to boys at 12 years, while it was higher in boys (9.1 %) at 16 years and 18 years. A steep increase was observed in the cortical area for height and cortical thickness for height in both sexes.

Conclusion: We have established reference curves for pQCT parameters in Indian children and adolescents to aid in the assessment of pediatric bone geometry.

目前，印度儿童的骨几何和强度参数数据缺乏。这是至关重要的，因为印度儿童和西方人口在身高、身体组成和骨骼结果方面存在差异，而这些都是现有参考数据的基础。由于双能x线吸收仪依赖于尺寸，我们进行了本研究，目的是为印度儿童和青少年的外周定量计算机断层扫描（pQCT）生成年龄和性别特异性的参考百分位曲线。方法：2017年11月至2022年7月，对来自印度浦那的961名（501名）8至18岁健康儿童进行了横断面观察性研究。使用XCT-2000 pQCT扫描仪（strategy Inc, GmbH, Pforzheim, Germany）测量左桡骨66%部位的体积小梁密度和体积皮质密度、极应力-应变指数、皮质厚度和肌肉面积。结果：我们给出了年龄的总、小梁和皮质密度的百分位数曲线，以及身高的皮质面积和皮质厚度的百分位数曲线。在17岁的男孩中观察到总体积密度最大增加10.7%，而在15岁的女孩中观察到最大增加8%。小梁密度平均每年增加0.2%。从13岁开始，女孩的皮质密度明显高于男孩（8.7%）。女孩在12岁时的皮质厚度明显高于男孩（13.3%），而男孩在16岁和18岁时的皮质厚度则高于男孩（9.1%）。在两性中，身高的皮质面积和身高的皮质厚度都急剧增加。结论：我们建立了印度儿童和青少年pQCT参数的参考曲线，以帮助评估儿童骨骼几何形状。

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引用次数: 0

Total-body versus knee-specific dual-energy X-ray absorptiometry scans for assessing bone mineral density surrounding the knee joint in collegiate athletes with and without an anterior cruciate ligament reconstruction 在有或没有前交叉韧带重建的大学生运动员中，全身与膝关节特异性双能x线吸收仪扫描评估膝关节周围骨密度

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-11-22 DOI: 10.1016/j.jocd.2025.101657

Keith A. Knurr , James P. Lyon , Neil C. Binkley , Tamara A. Scerpella , Bryan C. Heiderscheit

Following anterior cruciate ligament reconstruction (ACLR), athletes demonstrate reduced bone mineral density (BMD) surrounding the knee that persists for years. These changes have been identified using total-body and site-specific dual-energy X-ray absorptiometry (DXA) scans. It is unknown whether these two scan types provide comparable measures of BMD. This study assessed the agreement between total-body and knee-specific DXA scans for measuring BMD of the distal femur and proximal tibia in Division I collegiate athletes with and without an ACLR. We further assessed the influence of surgical hardware on BMD with and without the use of the manual artifact correction tool in athletes post-ACLR. Collegiate athletes (healthy: 46; post-ACLR: 20) were included. Regions of interest (ROI) were placed at the 5 % and 15 % lengths of the distal femur and the proximal tibia to assess BMD of each limb on total-body and knee-specific scans. BMD values for each limb and between-limb asymmetry were compared between scan types at each ROI using Bland-Altman analyses. Mean differences are reported as total-body minus knee-specific values. Total-body scans provided significantly lower BMD than knee-specific scans for all ROIs (-0.102 to -0.038 g/cm², all p-values < 0.01) except for the tibia 5 % (0.047 g/cm², p < 0.01) in healthy athletes. No differences in between-limb asymmetry were detected between scan types in healthy athletes (-0.78 % to 0.56 %; all p-values > 0.11). Athletes post-ACLR had more pronounced differences in BMD between scan types (-0.245 to -0.064 g/cm², all p-values < 0.02) and wider limits of agreement when surgical hardware was present, but this effect was mitigated when the manual artifact correction tool was used to exclude hardware (-0.122 to -0.008 g/cm², p-values from <0.01 to 0.57). Despite differences in absolute BMD, this study supports the use of total-body scans for assessing between-limb asymmetry in knee-specific regions in healthy athletes and in athletes post-ACLR when excluding hardware.

在前交叉韧带重建（ACLR）后，运动员表现出持续数年的膝关节周围骨密度（BMD）降低。这些变化已通过全身和特定部位双能x射线吸收仪（DXA）扫描确定。目前尚不清楚这两种扫描类型是否提供可比较的BMD测量。本研究评估了在有和没有ACLR的一级大学运动员中，全身和膝关节特异性DXA扫描测量股骨远端和胫骨近端骨密度之间的一致性。我们进一步评估了在aclr后使用和不使用人工人工校正工具时手术器械对运动员骨密度的影响。包括大学运动员（健康：46；aclr后：20）。感兴趣区域（ROI）分别位于股骨远端和胫骨近端长度的5%和15%处，以评估全身和膝关节特异性扫描中每个肢体的骨密度。使用Bland-Altman分析比较每个ROI扫描类型的每肢和肢间不对称性的BMD值。平均差异报告为全身减去膝盖特定值。除了健康运动员的胫骨5% （0.047 g/cm2, p < 0.01）外，全身扫描提供的骨密度显著低于膝关节特定扫描的所有roi（-0.102至-0.038 g/cm2，所有p值<； 0.01）。在健康运动员的不同扫描类型中，肢间不对称性没有差异（- 0.78%至0.56%；所有p值>； 0.11）。aclr后运动员在不同扫描类型之间的骨密度差异更明显（-0.245至-0.064 g/cm2，所有p值均为<； 0.02），当有手术器械存在时，这种差异更大，但当使用人工伪像校正工具排除器械时，这种影响减弱了（-0.122至-0.008 g/cm2， p值为<；0.01至0.57）。尽管绝对骨密度存在差异，但本研究支持使用全身扫描来评估健康运动员和aclr后运动员在排除硬件时膝关节特定区域的肢间不对称性。

{"title":"Total-body versus knee-specific dual-energy X-ray absorptiometry scans for assessing bone mineral density surrounding the knee joint in collegiate athletes with and without an anterior cruciate ligament reconstruction","authors":"Keith A. Knurr , James P. Lyon , Neil C. Binkley , Tamara A. Scerpella , Bryan C. Heiderscheit","doi":"10.1016/j.jocd.2025.101657","DOIUrl":"10.1016/j.jocd.2025.101657","url":null,"abstract":"<div><div>Following anterior cruciate ligament reconstruction (ACLR), athletes demonstrate reduced bone mineral density (BMD) surrounding the knee that persists for years. These changes have been identified using total-body and site-specific dual-energy X-ray absorptiometry (DXA) scans. It is unknown whether these two scan types provide comparable measures of BMD. This study assessed the agreement between total-body and knee-specific DXA scans for measuring BMD of the distal femur and proximal tibia in Division I collegiate athletes with and without an ACLR. We further assessed the influence of surgical hardware on BMD with and without the use of the manual artifact correction tool in athletes post-ACLR. Collegiate athletes (healthy: 46; post-ACLR: 20) were included. Regions of interest (ROI) were placed at the 5 % and 15 % lengths of the distal femur and the proximal tibia to assess BMD of each limb on total-body and knee-specific scans. BMD values for each limb and between-limb asymmetry were compared between scan types at each ROI using Bland-Altman analyses. Mean differences are reported as total-body minus knee-specific values. Total-body scans provided significantly lower BMD than knee-specific scans for all ROIs (-0.102 to -0.038 g/cm<sup>2</sup>, all p-values < 0.01) except for the tibia 5 % (0.047 g/cm<sup>2</sup>, <em>p</em> < 0.01) in healthy athletes. No differences in between-limb asymmetry were detected between scan types in healthy athletes (-0.78 % to 0.56 %; all p-values > 0.11). Athletes post-ACLR had more pronounced differences in BMD between scan types (-0.245 to -0.064 g/cm<sup>2</sup>, all p-values < 0.02) and wider limits of agreement when surgical hardware was present, but this effect was mitigated when the manual artifact correction tool was used to exclude hardware (-0.122 to -0.008 g/cm<sup>2</sup>, p-values from <0.01 to 0.57). Despite differences in absolute BMD, this study supports the use of total-body scans for assessing between-limb asymmetry in knee-specific regions in healthy athletes and in athletes post-ACLR when excluding hardware.</div></div>","PeriodicalId":50240,"journal":{"name":"Journal of Clinical Densitometry","volume":"29 1","pages":"Article 101657"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Radiation therapy–Associated bone attenuation loss in anorectal cancer: Need for standardized imaging and clinical correlation” [Journal of Clinical Densitometry Volume 28 (2025) 101629] “肛肠癌放射治疗相关骨衰减损失：需要标准化成像和临床相关性”的勘误表[Journal of clinical density Volume 28 (2025) 101629]

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.1016/j.jocd.2025.101655

Parth Aphale, Himanshu Shekhar, Shashank Dokania

引用次数: 0

Bone density, structure, and estimated strength in children with congenital heart disease. A CHAMPS* cohort study 先天性心脏病儿童的骨密度、结构和估计强度。一项champ *队列研究。

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-10-25 DOI: 10.1016/j.jocd.2025.101636

Marta C. Erlandson , Matthew S. Chapelski , Chantelle L. Baril , Charissa Pockett , Scott Pharis , Kristi D. Wright , Corey R. Tomczak

Introduction: Children with congenital heart disease (CHD) have lower levels of physical activity, lower birth weights, and lower nutrient intake compared to their typically developing peers (TDP); which can put children with CHD at increased risk of impaired skeletal development. Therefore, the purpose of this study was to assess the bone architecture of children with CHD compared to TDP. Our secondary objective was to evaluate differences between CHD lesion complexity.

Methods: Forty-two children with CHD 7 to 15 years of age (10.9±2.5) were age and sex-matched to 41 TDP. Peripheral quantitative computed tomography (pQCT) scans were obtained at the distal (4%) and shaft (65%, 66%) sites for the radius and tibia, respectively. pQCT bone parameters were compared between groups using multiple analysis of covariance (MANCOVA), using sex, age, height, weight, maturity, and physical activity as covariates.

Results: There were no significant differences between children with CHD and TDP at the distal radius or distal tibia (p>0.05). Children with CHD had significantly lower total area, cortical content, cortical area, cortical thickness, and polar stress-strain index at the radial and tibial shaft compared to TDP (p<0.05). When sub-dividing children with CHD by lesion severity, the complex CHD group had significantly lower cortical content, cortical area, cortical thickness, and polar stress-strain index at the radius and tibia shaft when compared to TDP (p<0.05). Additionally, children with complex lesions had greater cortical density at the radius and tibia shaft when compared to TDP (p<0.05). Finally, children with simple lesions had greater cortical density at the radius shaft when compared to TDP (p<0.05).

Conclusion: Children with complex CHD had worse bone parameters when compared to TDP. Children with complex CHD lesions may be at increased risk of impaired bone density, structure, and estimated strength at both the radius and tibia shaft.

与正常发育的同龄人（TDP）相比，患有先天性心脏病（CHD）的儿童身体活动水平较低，出生体重较低，营养摄入量较低；这会增加患有冠心病的儿童骨骼发育受损的风险。因此，本研究的目的是评估与TDP相比，CHD儿童的骨结构。我们的次要目的是评估冠心病病变复杂性的差异。方法：7 ~ 15岁（10.9±2.5）例冠心病患儿42例，年龄、性别匹配41例。周围定量计算机断层扫描（pQCT）分别在桡骨和胫骨的远端（4%）和轴端（65%,66%）进行扫描。采用多元协方差分析（MANCOVA），以性别、年龄、身高、体重、成熟度和体力活动为协变量，比较各组间pQCT骨骼参数。结果：冠心病患儿桡骨远端和胫骨远端TDP差异无统计学意义（p < 0.05）。与TDP相比，冠心病患儿桡骨和胫骨干的总面积、皮质含量、皮质面积、皮质厚度和极性应力-应变指数均显著降低(p)。结论：复杂型冠心病患儿的骨参数较TDP差。患有复杂冠心病病变的儿童在桡骨和胫骨干的骨密度、结构和估计强度受损的风险可能会增加。

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引用次数: 0

Impact of DXA acquisition mode on bone mineral density and longitudinal monitoring: Evidence from the Manitoba BMD registry DXA采集模式对骨密度和纵向监测的影响：来自马尼托巴骨密度登记的证据

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-12-28 DOI: 10.1016/j.jocd.2025.101660

Sajjad Aftabi , William D. Leslie

Dual-energy X-ray absorptiometry (DXA) is the gold standard for assessing bone mineral density (BMD), but technical factors such as acquisition mode may affect measurement. On GE Healthcare DXA systems, Thin and Thick modes are often recommended for underweight and obese patients, respectively, while Standard mode is the default. Using the Manitoba Bone Density Program, a population-based registry, we analyzed paired same-day BMD measurements for the lumbar spine (n = 240), total hip (n = 432), and femoral neck (n = 431) obtained in Standard and nonstandard modes. Agreement was assessed by linear regression, Pearson correlation, Bland–Altman plots, and classification of BMD change using site-specific least significant change (LSC) thresholds. Paired Standard and nonstandard modes showed very strong correlations (r ≥ 0.97) with regression slopes approximating unity and intercepts approximating zero. Mean biases were negligible at the lumbar spine (−0.002 g/cm²), total hip (+0.001 g/cm²), and femoral neck (+0.001 g/cm²). Overall Standard versus nonstandard mode change agreement was near-perfect at the spine (Cohen’s κ 0.89) and total hip (κ 0.81), and substantial at the femoral neck (κ 0.75). All observed scan mode differences fell well below established LSC thresholds. These findings demonstrate that Thin and Thick acquisition modes produce BMD results that are effectively interchangeable with Standard mode.

双能x线吸收仪（DXA）是评估骨密度（BMD）的金标准，但采集方式等技术因素可能会影响测量。在GE Healthcare DXA系统上，通常分别推荐体重过轻和肥胖患者使用Thin和Thick模式，而标准模式是默认模式。使用马尼托巴骨密度计划，一个基于人群的登记，我们分析了在标准和非标准模式下获得的腰椎（n = 240）、全髋关节（n = 432）和股骨颈（n = 431）的配对当日骨密度测量值。通过线性回归、Pearson相关性、Bland-Altman图和使用位点特异性最不显著变化（LSC）阈值的BMD变化分类来评估一致性。配对的标准模式和非标准模式显示出很强的相关性（r≥0.97），回归斜率接近于1，截距接近于零。腰椎（- 0.002 g/cm²）、全髋关节（+0.001 g/cm²）和股骨颈（+0.001 g/cm²）的平均偏差可以忽略不计。总体而言，标准与非标准模式改变的一致性在脊柱（Cohen’s κ 0.89）和全髋关节（κ 0.81）处接近完美，在股骨颈（κ 0.75）处相当可观。所有观察到的扫描模式差异都低于既定的LSC阈值。这些发现表明，薄采集模式和厚采集模式产生的BMD结果与标准模式可以有效地互换。

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引用次数: 0

Graves' disease and bone mineral density: a scoping review of the impact of graves’ disease on spinal health Graves病与骨矿物质密度：Graves病对脊柱健康影响的范围综述

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-08-05 DOI: 10.1016/j.jocd.2025.101621

Mira Al Shoufy , Jamil Nasrallah , Kholoud Al Jebawi , Hady El Etry , Murtaja Satea Shafeea , Ibrahim Hassan , Haya Mohamed , Naseeb Danaf , Hossam Tharwat Ali

Graves' disease, an autoimmune hyperthyroid disorder, negatively affects bone health by increasing osteoclast activity, leading to decreased bone mineral density (BMD) and heightened osteoporosis risk. Bone loss may persist even after thyroid levels normalize, possibly due to thyroid-stimulating hormone receptor antibodies (TRAb). This scoping review evaluates the impact of Graves' disease and its treatment on BMD, focusing on TRAb's role in bone loss. Using Arksey and O’Malley's framework, we searched Medline/PubMed, Scopus, Web of Science, and Cochrane Library for English-language studies on the effects of Graves' disease on adult spine-related bone health. From 2,226 records, 16 studies met the inclusion criteria after screening titles, abstracts, and full texts. Studies focusing primarily on postmenopausal women and older men consistently showed reduced BMD in patients with Graves' disease, especially in the lumbar spine. Elevated TRAb levels correlated with lower BMD, suggesting that TRAb contributes to ongoing bone loss despite achieving an euthyroid state. Anti-thyroid drug therapy partially improved BMD, but bone loss often persisted. Combining bisphosphonates with anti-thyroid therapy enhanced BMD recovery more than anti-thyroid therapy alone. Graves' disease affects bone health through thyroid hormone excess and TRAb-mediated autoimmunity, with persistent bone loss even after achieving an euthyroid state. High-risk groups like postmenopausal women and older men require targeted strategies addressing both thyroid and skeletal health. Future research should focus on therapies targeting TRAb and improving osteoporosis prevention to enhance outcomes.

Graves病是一种自身免疫性甲状腺功能亢进疾病，通过增加破骨细胞活性，导致骨密度（BMD）下降和骨质疏松症风险增加，对骨骼健康产生负面影响。即使甲状腺水平恢复正常，骨质流失仍可能持续存在，这可能是由于促甲状腺激素受体抗体（TRAb）所致。本综述评估了Graves病及其治疗对骨密度的影响，重点关注TRAb在骨质流失中的作用。使用Arksey和O ' malley的框架，我们检索了Medline/PubMed、Scopus、Web of Science和Cochrane Library，查找有关Graves病对成人脊柱相关骨骼健康影响的英语研究。从2226条记录中，筛选标题、摘要和全文后，有16项研究符合纳入标准。主要针对绝经后女性和老年男性的研究一致表明，Graves病患者的骨密度降低，尤其是腰椎。TRAb水平升高与较低的骨密度相关，表明TRAb有助于持续的骨质流失，尽管达到了甲状腺功能正常的状态。抗甲状腺药物治疗部分改善了骨密度，但骨质流失往往持续存在。双膦酸盐联合抗甲状腺治疗比单独抗甲状腺治疗更能促进骨密度恢复。Graves病通过甲状腺激素过量和trab介导的自身免疫影响骨骼健康，即使在达到甲状腺功能正常状态后也会持续骨质流失。像绝经后妇女和老年男性这样的高危人群需要针对甲状腺和骨骼健康的针对性策略。未来的研究应侧重于针对TRAb的治疗和改善骨质疏松症的预防，以提高疗效。

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引用次数: 0

Metabolic and body composition alterations in normal-weight adults with prediabetes: A DEXA-based analysis 正常体重的糖尿病前期成人代谢和身体成分的改变：一项基于dexa的分析

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-12-28 DOI: 10.1016/j.jocd.2025.101662

Sami Bahçebaşı , Banu Açmaz , Ahmet Savranlar

Introduction: This study examines clinical, biochemical, and body composition differences between healthy and prediabetic normal-weight individuals (BMI 18.5-24.9 kg/m²), with a focus on central fat distribution.

Methods: Sixty participants (30 prediabetic, 30 healthy) underwent clinical evaluations, including body composition analysis using DEXA.

Results: • Women: Multivariate regression analysis demonstrated that the android-to-gynoid fat ratio remained an independent and significant predictor of prediabetes (p = 0.014).

• Men: GFR and creatinine levels were significantly impaired (p = 0.008, p = 0.019). Central fat distribution, especially trunk fat, correlated with fasting glucose, although this association lost significance after age adjustment.

Discussion: In women, prediabetes is associated with impaired glucose metabolism and central fat accumulation, particularly reflected by an elevated DEXA-derived android/gynoid fat ratio, highlighting a “normal-weight obesity” phenotype even in individuals with normal BMI. In men, central fat distribution, especially the trunk-to-limb fat ratio, is linked to glucose metabolism; however, this relationship diminishes after adjusting for age, suggesting that age-related fat redistribution may modulate metabolic risk. Additionally, early renal dysfunction, as indicated by reduced eGFR, is evident in men with prediabetes, underscoring the importance of comprehensive metabolic and renal assessment. These findings emphasize the clinical relevance of body composition–based screening, particularly using DEXA-derived regional fat ratios, to identify high-risk normal-weight individuals and enable timely preventive interventions.

本研究探讨了健康和糖尿病前期正常体重个体（BMI 18.5-24.9 kg/m²）的临床、生化和身体组成差异，重点研究了中心脂肪分布。方法：60名参与者（30名糖尿病前期，30名健康）接受临床评估，包括DEXA身体成分分析。•女性：多变量回归分析表明，男性与女性的脂肪比仍然是前驱糖尿病的独立且显著的预测因子（p = 0.014）。•男性：GFR和肌酐水平显著降低（p = 0.008, p = 0.019）。中心脂肪分布，特别是躯干脂肪，与空腹血糖相关，尽管这种关联在年龄调整后失去了意义。讨论：在女性中，前驱糖尿病与糖代谢受损和中枢脂肪积累有关，特别是由dexa衍生的android/gynoid脂肪比例升高反映，即使在BMI正常的个体中也突出了“正常体重肥胖”表型。在男性中，中心脂肪分布，特别是躯干与四肢的脂肪比例，与葡萄糖代谢有关；然而，在调整年龄后，这种关系减弱，这表明与年龄相关的脂肪再分配可能会调节代谢风险。此外，早期肾功能障碍，如eGFR降低，在糖尿病前期男性中很明显，强调了综合代谢和肾脏评估的重要性。这些发现强调了基于身体成分的筛查的临床意义，特别是使用dexa衍生的区域脂肪比，以识别高危正常体重个体并及时进行预防性干预。

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Reframing the BMI–BMD–TBS triad in type 2 diabetes: Clinical and policy implications 重塑2型糖尿病的BMI-BMD-TBS三联征：临床和政策意义

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Clinical Densitometry

Pub Date : 2026-01-01 Epub Date: 2025-12-13 DOI: 10.1016/j.jocd.2025.101659

Amit Kumar Gupta, Anusha Putcha, Varshini Vadhithala, Sachin Kumar

引用次数: 0