Pub Date : 2023-12-19DOI: 10.21608/bmfj.2023.244262.1934
Omnia Farid, Mohamed Higazy, Hamdy El Gazzar, Mohamed Awwad, Taher K Eleiwa
: Background: Ocular manifestations of rheumatoid arthritis (RA) include dry eye (DE), episcleritis, scleritis, and peripheral ulcerative keratitis (PUK). The most common form of ocular involvement is DE. Purpose: To generate corneal thickness (CT) and corneal epithelial thickness (CET) maps using anterior segment optical coherence tomography (AS¬¬-OCT) in RA patients and compare those parameters with normal subjects. Materials and Methods: A case-control study was done on 35 eyes of 18 RA patients and 25 eyes of 14 healthy individuals recruited from Benha University Hospitals. All the included cases were subjected to full history taking and ophthalmological examination. All participants were successfully imaged using AS-OCT with subsequent automated CT and CET mapping. The disease activity score (DAS-28) was calculated for RA patients. Results: RA patients had significantly thinner CT in all regions (p<0.05, p≤0.001) and their epithelium was found to be thinner in the superior and the superonasal sectors in RA with DE (RA-DE) subgroup (p=0.002 and p=0.004, respectively) than the controls. There was statistically significant positive correlation between “mean (CT, CET)” and TBUT (r=0.352, p=0.006 and r=0.493, p<0.001, respectively). There was statistically significant negative correlation between mean CET and (OSDI, disease duration, DAS, ESR) (r=-0.603, p<0.001, r=-0.468, p<0.005, r=-0.57, p=0.001 and r=-0.547, p<0.001, respectively), while the mean CT had no significant correlation with these parameters. Conclusion: RA patients had thinner CT than controls, which correlated with TBUT and thinner CET in RA-DE subgroup which correlated with all parameters (TBUT, OSDI, disease duration, DAS, ESR)
:背景：类风湿性关节炎（RA）的眼部表现包括干眼症（DE）、上巩膜炎、巩膜炎和周围溃疡性角膜炎（PUK）。最常见的眼部受累形式是干眼症。目的：使用前段光学相干断层扫描（AS¬¬-OCT）生成RA患者的角膜厚度（CT）和角膜上皮厚度（CET）图，并将这些参数与正常人进行比较。材料与方法：对从本哈大学医院招募的18名RA患者的35只眼睛和14名健康人的25只眼睛进行了病例对照研究。所有病例均接受了全面的病史采集和眼科检查。所有参与者都成功地使用 AS-OCT 进行了成像，随后进行了自动 CT 和 CET 测绘。计算了 RA 患者的疾病活动评分（DAS-28）。结果显示与对照组相比，RA 患者所有区域的 CT 都明显变薄（p<0.05，p≤0.001），而且在 RA 伴 DE（RA-DE）亚组中，上皮细胞在鼻腔上部和鼻腔上部更薄（分别为 p=0.002 和 p=0.004）。平均值（CT、CET）"与 TBUT 之间存在统计学意义上的明显正相关（r=0.352，p=0.006 和 r=0.493，p<0.001）。平均 CET 与（OSDI、病程、DAS、ESR）之间存在统计学意义上的明显负相关（分别为 r=-0.603，p<0.001；r=-0.468，p<0.005；r=-0.57，p=0.001 和 r=-0.547，p<0.001），而平均 CT 与这些参数没有明显相关性。结论与对照组相比，RA 患者的 CT 更薄，这与 TBUT 相关，RA-DE 亚组的 CET 更薄，这与所有参数（TBUT、OSDI、病程、DAS、ESR）相关。
{"title":"Corneal Thickness Mapping in Rheumatoid Arthritis Patients Using Anterior-Segment Optical Coherence Tomography","authors":"Omnia Farid, Mohamed Higazy, Hamdy El Gazzar, Mohamed Awwad, Taher K Eleiwa","doi":"10.21608/bmfj.2023.244262.1934","DOIUrl":"https://doi.org/10.21608/bmfj.2023.244262.1934","url":null,"abstract":": Background: Ocular manifestations of rheumatoid arthritis (RA) include dry eye (DE), episcleritis, scleritis, and peripheral ulcerative keratitis (PUK). The most common form of ocular involvement is DE. Purpose: To generate corneal thickness (CT) and corneal epithelial thickness (CET) maps using anterior segment optical coherence tomography (AS¬¬-OCT) in RA patients and compare those parameters with normal subjects. Materials and Methods: A case-control study was done on 35 eyes of 18 RA patients and 25 eyes of 14 healthy individuals recruited from Benha University Hospitals. All the included cases were subjected to full history taking and ophthalmological examination. All participants were successfully imaged using AS-OCT with subsequent automated CT and CET mapping. The disease activity score (DAS-28) was calculated for RA patients. Results: RA patients had significantly thinner CT in all regions (p<0.05, p≤0.001) and their epithelium was found to be thinner in the superior and the superonasal sectors in RA with DE (RA-DE) subgroup (p=0.002 and p=0.004, respectively) than the controls. There was statistically significant positive correlation between “mean (CT, CET)” and TBUT (r=0.352, p=0.006 and r=0.493, p<0.001, respectively). There was statistically significant negative correlation between mean CET and (OSDI, disease duration, DAS, ESR) (r=-0.603, p<0.001, r=-0.468, p<0.005, r=-0.57, p=0.001 and r=-0.547, p<0.001, respectively), while the mean CT had no significant correlation with these parameters. Conclusion: RA patients had thinner CT than controls, which correlated with TBUT and thinner CET in RA-DE subgroup which correlated with all parameters (TBUT, OSDI, disease duration, DAS, ESR)","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"94 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139172258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-16DOI: 10.21608/bmfj.2023.212842.1827
ahmed M.Deabes, Shawky A. Elmeleigy, Mohamed S.Osman
Background: Accidents, falls, assaults, and sports all contribute to the prevalence of cervical subluxation. Purpose: Predictive indicators and the extent to which patients recover from surgery for severe cervical subluxation are explored. Study design: A look back at the show's history. Patient and methods: Between March 2019 and August 2021, data on 41 patients with cervical subluxation were gathered, including demographics, presentation, imaging results, surgery details, and the ASIA scale. Results: Age, sex, related injuries, degree, and level of subluxation were not significant in a study of 41 individuals with traumatic subluxations. The ASIA scale demonstrated to be an important predictor of surgical success, and improvements in patient measurement on the other two criteria also accounted for the remaining significant p-value. The second aspect is the signal strength of cord edoema, which allows for valuable assessment and prediction of the result; for example, in 15 patients, G2 had a high significant p-value 0.001, indicating an improvement of at least one grade in the ASIA scale. Seventeen patients (with a p-value 0.001) underwent surgery within three days, suggesting that this is a substantial and favourable prognostic factor.
背景：意外事故、跌倒、攻击和运动都会导致颈椎脱位的发生。目的：探讨重度颈椎脱位手术的预测指标和患者的康复程度。研究设计：回顾演出历史。患者和方法：2019年3月至2021年8月期间，收集了41名颈椎脱位患者的数据，包括人口统计学、表现、影像学结果、手术详情和ASIA量表。结果如下在对41名外伤性颈椎半脱位患者的研究中，年龄、性别、相关损伤、半脱位程度和水平均无显著性差异。ASIA 量表被证明是预测手术成功与否的重要指标，患者在其他两个标准上的测量结果的改善也是剩余显著 p 值的原因。第二个方面是脐带水肿的信号强度，这可以对结果进行有价值的评估和预测；例如，在 15 名患者中，G2 的 p 值为 0.001，具有高度显著性，表明 ASIA 量表中至少有一个等级的改善。有 17 名患者（p 值为 0.001）在三天内接受了手术，这表明这是一个重要而有利的预后因素。
{"title":"An analysis of predicting factors for surgical outcomes in traumatic cervical spine subluxation operated with cages and plates","authors":"ahmed M.Deabes, Shawky A. Elmeleigy, Mohamed S.Osman","doi":"10.21608/bmfj.2023.212842.1827","DOIUrl":"https://doi.org/10.21608/bmfj.2023.212842.1827","url":null,"abstract":"Background: Accidents, falls, assaults, and sports all contribute to the prevalence of cervical subluxation. Purpose: Predictive indicators and the extent to which patients recover from surgery for severe cervical subluxation are explored. Study design: A look back at the show's history. Patient and methods: Between March 2019 and August 2021, data on 41 patients with cervical subluxation were gathered, including demographics, presentation, imaging results, surgery details, and the ASIA scale. Results: Age, sex, related injuries, degree, and level of subluxation were not significant in a study of 41 individuals with traumatic subluxations. The ASIA scale demonstrated to be an important predictor of surgical success, and improvements in patient measurement on the other two criteria also accounted for the remaining significant p-value. The second aspect is the signal strength of cord edoema, which allows for valuable assessment and prediction of the result; for example, in 15 patients, G2 had a high significant p-value 0.001, indicating an improvement of at least one grade in the ASIA scale. Seventeen patients (with a p-value 0.001) underwent surgery within three days, suggesting that this is a substantial and favourable prognostic factor.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"175 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-16DOI: 10.21608/bmfj.2023.225822.1865
Mohamed A. Mohamed, Abdelmoneim Ahmed, H. Eleleimy, Ahmed E Mansour, Shireen Mohsen Salem
: Background: One of the most serious complications among cancer patients is Acute Kidney Injury (AKI). This study aimed to detect the AKI incidence in cancer patients, to discover which clinical factors could increase the risks of AKI, and to assess the effect of AKI on in-hospital mortality, length of stay. Methods: This prospective cohort study was conducted on 276 malignant patients (AKI: 40 cases and no AKI: 236 cases). Serum creatinine, blood urea, complete blood count, uric acid, Electrolyte'' potassium, sodium, calcium'', urine analysis with comment on RBCs cast, liver function test'' ALT, AST, Albumin and bilirubin'' were measured every three weeks, and urine albumin creatinine ratio was done before chemotherapy and after finishing treatment. Results: pre-existing comorbidities including hypertension (HTN), diabetes (DM), and coronary heart disease are significant predictors for increased risk of AKI in cancer patients. Patients with hyponatremia, hypokalemia and hyperuricemia shared a significantly higher risk of AKI (a OR = 2.95, 2.49, and 3.01). Cox regression analysis revealed that HTN and DM also increased the mortality risk when adjusting demographic and clinical features. The mean survival rate was significantly lower in group with AKI compared to group without AKI (16.331 versus 19.589). AKI stage II and III had longer median length of hospital stay compared to stage I.
:背景：急性肾损伤（AKI）是癌症患者最严重的并发症之一。本研究旨在检测癌症患者急性肾损伤的发生率，发现哪些临床因素会增加急性肾损伤的风险，并评估急性肾损伤对院内死亡率和住院时间的影响。研究方法这项前瞻性队列研究的对象是 276 例恶性肿瘤患者（AKI：40 例，无 AKI：236 例）。每三周测量一次血清肌酐、血尿素、全血细胞计数、尿酸、电解质 "钾、钠、钙"、尿液分析，并对 RBC 进行评论，肝功能检测 "ALT、AST、白蛋白和胆红素"，化疗前和治疗结束后进行尿白蛋白肌酐比值检测。结果：癌症病人原有的合并症，包括高血压（HTN）、糖尿病（DM）和冠心病，是增加其发生 AKI 风险的重要预测因素。低钠血症、低钾血症和高尿酸血症患者发生 AKI 的风险明显更高（OR = 2.95、2.49 和 3.01）。Cox 回归分析显示，调整人口统计学和临床特征后，高血压和糖尿病也会增加死亡风险。与无 AKI 组相比，有 AKI 组的平均存活率明显较低（16.331 对 19.589）。与 AKI I 期相比，AKI II 期和 III 期的中位住院时间更长。
{"title":"Epidemiology of Acute Kidney Injury and Associated Factors among Patients with Malignancy: Analysis of Hospital Inpatients Database in Benha university Hospital Internal Medicine Departement, Hematology and Oncology Unit","authors":"Mohamed A. Mohamed, Abdelmoneim Ahmed, H. Eleleimy, Ahmed E Mansour, Shireen Mohsen Salem","doi":"10.21608/bmfj.2023.225822.1865","DOIUrl":"https://doi.org/10.21608/bmfj.2023.225822.1865","url":null,"abstract":": Background: One of the most serious complications among cancer patients is Acute Kidney Injury (AKI). This study aimed to detect the AKI incidence in cancer patients, to discover which clinical factors could increase the risks of AKI, and to assess the effect of AKI on in-hospital mortality, length of stay. Methods: This prospective cohort study was conducted on 276 malignant patients (AKI: 40 cases and no AKI: 236 cases). Serum creatinine, blood urea, complete blood count, uric acid, Electrolyte'' potassium, sodium, calcium'', urine analysis with comment on RBCs cast, liver function test'' ALT, AST, Albumin and bilirubin'' were measured every three weeks, and urine albumin creatinine ratio was done before chemotherapy and after finishing treatment. Results: pre-existing comorbidities including hypertension (HTN), diabetes (DM), and coronary heart disease are significant predictors for increased risk of AKI in cancer patients. Patients with hyponatremia, hypokalemia and hyperuricemia shared a significantly higher risk of AKI (a OR = 2.95, 2.49, and 3.01). Cox regression analysis revealed that HTN and DM also increased the mortality risk when adjusting demographic and clinical features. The mean survival rate was significantly lower in group with AKI compared to group without AKI (16.331 versus 19.589). AKI stage II and III had longer median length of hospital stay compared to stage I.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"476 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Neonatal sepsis is a systemic condition involving hemodynamic changes and clinical manifestations caused by bacterial, viral, or fungal infection that occurs within the first 28 days of life. This study aimed to assess the accuracy of Presepsin for diagnosis and early detection of sepsis and septic shock among preterm neonates. Methods: This Cross-sectional study included 75 preterm neonates with symptoms suspicious of sepsis. They were classified into 3 groups: Group 1; Infection (suspected infection not meeting the criteria for sepsis). Group 2; Sepsis (neonatal systemic inflammatory response syndrome, SIRS, plus suspected or proven infection). Group 3; Septic shock (sepsis plus cardiovascular organ dysfunction). Detailed history, clinical examination, laboratory investigations: Complete blood picture (CBC), C-Reactive Protein (CRP), blood culture and determination of Human Presepsin level in the Blood (PSEP). Results : Presepsin level was significantly lower at D3 and D5 compared to D1 (P<0.001). whereas, in group 3 (Septic shock), Presepsin level was significantly lower at D5 compared to D1 (P=0.007). only PLT count, CRP, Presepsin at D1, Presepsin at D3 and Presepsin at D5-were significant predictors of neonatal sepsis and only APGAR at 5 min, PLT count, CRP, Presepsin at D1, Presepsin at D3 and Presepsin at D5-were significant predictors of septic shock in neonates. Conclusion: Presepsin is an accurate diagnostic biomarker for early diagnosis of sepsis compared to other acute phase reactant and inflammatory markers. Presepsin is a strong predictive marker for sepsis and septic shock from day1 to day 5 with high sensitivity and specificity.
{"title":"Presepsin as an early diagnostic marker in Premature infants with neonatal sepsis and septic shock","authors":"Ashraf Shahin, Omima Abdel haie, Sahar Fayed, Rime Abdelsalam","doi":"10.21608/bmfj.2023.245353.1940","DOIUrl":"https://doi.org/10.21608/bmfj.2023.245353.1940","url":null,"abstract":"Background: Neonatal sepsis is a systemic condition involving hemodynamic changes and clinical manifestations caused by bacterial, viral, or fungal infection that occurs within the first 28 days of life. This study aimed to assess the accuracy of Presepsin for diagnosis and early detection of sepsis and septic shock among preterm neonates. Methods: This Cross-sectional study included 75 preterm neonates with symptoms suspicious of sepsis. They were classified into 3 groups: Group 1; Infection (suspected infection not meeting the criteria for sepsis). Group 2; Sepsis (neonatal systemic inflammatory response syndrome, SIRS, plus suspected or proven infection). Group 3; Septic shock (sepsis plus cardiovascular organ dysfunction). Detailed history, clinical examination, laboratory investigations: Complete blood picture (CBC), C-Reactive Protein (CRP), blood culture and determination of Human Presepsin level in the Blood (PSEP). Results : Presepsin level was significantly lower at D3 and D5 compared to D1 (P<0.001). whereas, in group 3 (Septic shock), Presepsin level was significantly lower at D5 compared to D1 (P=0.007). only PLT count, CRP, Presepsin at D1, Presepsin at D3 and Presepsin at D5-were significant predictors of neonatal sepsis and only APGAR at 5 min, PLT count, CRP, Presepsin at D1, Presepsin at D3 and Presepsin at D5-were significant predictors of septic shock in neonates. Conclusion: Presepsin is an accurate diagnostic biomarker for early diagnosis of sepsis compared to other acute phase reactant and inflammatory markers. Presepsin is a strong predictive marker for sepsis and septic shock from day1 to day 5 with high sensitivity and specificity.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"24 5-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139184504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.21608/bmfj.2023.244171.1933
Ashraf Nassar, Mohamed El Shewi, Mona Mohammed, M. Gouda, Tamer Eleraky
: Background : Microscopic colitis (MC) is a chronic inflammatory bowel disease in the setting of normal appearing colonic mucosa and distinct histopathologic features . Microscopic colitis has two main subtypes, collagenous colitis (CC) and lymphocytic colitis (LC). Diagnosis of MC is mainly based on pathological examination of colonic biopsy. Aim : Estimation of MC among patients with normal or nonspecific colonoscopic findings. Methods : This cross-sectional study was conducted on (172) patients with normal or nonspecific colonoscopic findings. Full history taking, clinical examination, laboratory investigations, pelvi-abdominal ultrasound and complete colonoscopy examination were done. Endoscopic biopsies from the right and left side of the colon were taken for all patients for histopathological examination. Results : Of all the studied patients, 9 cases (5.2%) had MC with 6 patients (3.5%) having LC and 3 patients (1.8%) having CC. One hundred twenty-one cases were diagnosed as chronic nonspecific colitis (70.3%), 19 cases were diagnosed as chronic active colitis (11.1%) while 23 cases (13.3%) were normal. The median age of patients with MC was about 45 years and most of them were females. Univariate logistic regression analysis of predictors for developing MC showed that chronic diarrhea, chronic diarrhea duration and nonsteroidal anti-inflammatory drugs (NSAIDs) use are significant independent predictors for MC. Conclusion : MC could be considered in any patient with chronic lower gastrointestinal symptoms and apparently normal mucosa during colonoscopy examination. Multiple colonic biopsies should be taken from any patient with unexplained chronic lower gastrointestinal symptoms even with normal macroscopic picture to reach a definite diagnosis of MC.
:背景：显微镜下结肠炎（MC）是一种慢性炎症性肠病，结肠粘膜外观正常，组织病理学特征明显。显微镜下结肠炎有两个主要亚型，即胶原性结肠炎（CC）和淋巴细胞性结肠炎（LC）。MC的诊断主要依据结肠活检的病理检查。目的：估计结肠镜检查结果正常或无特异性的患者中 MC 的发病率。方法：本横断面研究的对象是结肠镜检查结果正常或非特异性的患者（172 人）。研究人员进行了全面的病史采集、临床检查、实验室检查、盆腹腔超声波检查和完整的结肠镜检查。所有患者均在结肠左右两侧进行了内窥镜活检，以进行组织病理学检查。结果：在所有研究的患者中，9 例（5.2%）患有 MC，6 例（3.5%）患有 LC，3 例（1.8%）患有 CC。121例被诊断为慢性非特异性结肠炎（70.3%），19例被诊断为慢性活动性结肠炎（11.1%），23例（13.3%）正常。MC 患者的年龄中位数约为 45 岁，大部分为女性。对罹患 MC 的预测因素进行的单变量逻辑回归分析表明，慢性腹泻、慢性腹泻持续时间和非甾体类抗炎药（NSAIDs）的使用是罹患 MC 的重要独立预测因素。结论：任何有慢性下消化道症状且结肠镜检查时粘膜明显正常的患者都应考虑患上 MC。任何不明原因的慢性下消化道症状患者，即使宏观检查结果正常，也应进行多次结肠活检，以明确诊断为MC。
{"title":"Prevalence of Microscopic Colitis in Patients with Normal or Nonspecific Colonoscopic Findings","authors":"Ashraf Nassar, Mohamed El Shewi, Mona Mohammed, M. Gouda, Tamer Eleraky","doi":"10.21608/bmfj.2023.244171.1933","DOIUrl":"https://doi.org/10.21608/bmfj.2023.244171.1933","url":null,"abstract":": Background : Microscopic colitis (MC) is a chronic inflammatory bowel disease in the setting of normal appearing colonic mucosa and distinct histopathologic features . Microscopic colitis has two main subtypes, collagenous colitis (CC) and lymphocytic colitis (LC). Diagnosis of MC is mainly based on pathological examination of colonic biopsy. Aim : Estimation of MC among patients with normal or nonspecific colonoscopic findings. Methods : This cross-sectional study was conducted on (172) patients with normal or nonspecific colonoscopic findings. Full history taking, clinical examination, laboratory investigations, pelvi-abdominal ultrasound and complete colonoscopy examination were done. Endoscopic biopsies from the right and left side of the colon were taken for all patients for histopathological examination. Results : Of all the studied patients, 9 cases (5.2%) had MC with 6 patients (3.5%) having LC and 3 patients (1.8%) having CC. One hundred twenty-one cases were diagnosed as chronic nonspecific colitis (70.3%), 19 cases were diagnosed as chronic active colitis (11.1%) while 23 cases (13.3%) were normal. The median age of patients with MC was about 45 years and most of them were females. Univariate logistic regression analysis of predictors for developing MC showed that chronic diarrhea, chronic diarrhea duration and nonsteroidal anti-inflammatory drugs (NSAIDs) use are significant independent predictors for MC. Conclusion : MC could be considered in any patient with chronic lower gastrointestinal symptoms and apparently normal mucosa during colonoscopy examination. Multiple colonic biopsies should be taken from any patient with unexplained chronic lower gastrointestinal symptoms even with normal macroscopic picture to reach a definite diagnosis of MC.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"31 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-23DOI: 10.21608/bmfj.2023.242125.1924
Mohamed Oraby, Mahmoud Mazoun, Ahmed Qassem Mohamed, Mai Fawzy, Taher Abdel-Aziz, Ismail Dahshan
Purpose: This study’s purpose was to assess the impact of metabolic associated fatty liver disease (MAFLD) on the outcome of patients affected by Corona Virus Disease – 2019 (COVID-19). Patients and Methods: This prospective observational study `was conducted on patients affected by COVID-19 who were treated at our Hospital from January 2022 to February 2023. The study involved 200 adult patients with confirmed COVID-19, excluding those with other chronic hepatic disorders, and included comprehensive clinical, laboratory, and ultrasonographic assessments. The existence of MAFLD was assessed as newly established, and the COVID-19 severity was evaluated per the Egyptian protocol, and the diagnosis of MAFLD followed international consensus criteria. Results: Patients with MAFLD and COVID-19 (Group I) had a significantly higher number of patients with severe disease (n = 60, 60%) than patients with COVID-19 alone (Group II) (n = 21, 21%, p < 0.001). The mortality rate was 11% (n = 22), with a significantly higher rate encountered in Group I (n = 16, 16% vs. n = 6, 6%, p = 0.024). Conclusion: Patients with MAFLD exhibited distinct clinical and laboratory features and were more likely to develop severe COVID-19, with a higher mortality rate.
{"title":"Study on the Impact of metabolic associated fatty liver disease (MAFLD) on patients with Corona Virus Disease – 2019 (COVID-19)","authors":"Mohamed Oraby, Mahmoud Mazoun, Ahmed Qassem Mohamed, Mai Fawzy, Taher Abdel-Aziz, Ismail Dahshan","doi":"10.21608/bmfj.2023.242125.1924","DOIUrl":"https://doi.org/10.21608/bmfj.2023.242125.1924","url":null,"abstract":"Purpose: This study’s purpose was to assess the impact of metabolic associated fatty liver disease (MAFLD) on the outcome of patients affected by Corona Virus Disease – 2019 (COVID-19). Patients and Methods: This prospective observational study `was conducted on patients affected by COVID-19 who were treated at our Hospital from January 2022 to February 2023. The study involved 200 adult patients with confirmed COVID-19, excluding those with other chronic hepatic disorders, and included comprehensive clinical, laboratory, and ultrasonographic assessments. The existence of MAFLD was assessed as newly established, and the COVID-19 severity was evaluated per the Egyptian protocol, and the diagnosis of MAFLD followed international consensus criteria. Results: Patients with MAFLD and COVID-19 (Group I) had a significantly higher number of patients with severe disease (n = 60, 60%) than patients with COVID-19 alone (Group II) (n = 21, 21%, p < 0.001). The mortality rate was 11% (n = 22), with a significantly higher rate encountered in Group I (n = 16, 16% vs. n = 6, 6%, p = 0.024). Conclusion: Patients with MAFLD exhibited distinct clinical and laboratory features and were more likely to develop severe COVID-19, with a higher mortality rate.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"43 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139246526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-23DOI: 10.21608/bmfj.2023.230952.1880
Ashraf Elmantwea, A. Negm, Y. Edris
Objective: To compare perioperative surgical, medical, and financial outcomes in morbidly obese women who underwent non-descent vaginal hysterectomy (NDVH) compared to total abdominal hysterectomy (TAH) for non-prolapse indications. Patients and methods: A retrospective analysis included 117 women who underwent hysterectomies performed between January 2015 and March 2023 in Benha University Hospital. The NDVH group included 55 women. The TAH group included 62 women. Results: Both NDVH and TAH groups participants had statistically indifferent pre-operative mean hemoglobin levels, age, parity, associated comorbidities, previous pelvic and abdominal surgery involving cesarean sections, and comparable indications for hysterectomy(p>0.05), but statistically higher BMI, HBA1c preoperative serum level, and shorter preoperative hospital admission (days), all these items favoring the superiority NDVH group over the TAH group( p =0.0001). There were no statistical differences between groups as regrades operative room time, operative blood loss, intra-operative complications, removed uterine weight in grams, and the need for blood transfusion (p>0.05). While there were high statistical differences (p<0.0001) favoring outcomes of NDVH over TAH including the need for general anesthesia, wound complications percentage (1% vs 72%), shorter postoperative hospital stays, less consumption of analgesic and shorter duration needs for postoperative venous thromboembolic prophylaxis, earlier ambulation, earlier to pass flatus. Approximate charges of both procedures were encouraging the NDVH over TAH (p<0.0001). Conclusion: In morbidly obese women with non-prolapsed uteri, the NDVH should be the primary route for hysterectomy, as the NDVH results is better than the TAH results in all perioperative outcomes items.
{"title":"Hysterectomy in morbidly obese women: a retrospective comparative analysis of routes vaginal versus abdominal in Benha University hospital","authors":"Ashraf Elmantwea, A. Negm, Y. Edris","doi":"10.21608/bmfj.2023.230952.1880","DOIUrl":"https://doi.org/10.21608/bmfj.2023.230952.1880","url":null,"abstract":"Objective: To compare perioperative surgical, medical, and financial outcomes in morbidly obese women who underwent non-descent vaginal hysterectomy (NDVH) compared to total abdominal hysterectomy (TAH) for non-prolapse indications. Patients and methods: A retrospective analysis included 117 women who underwent hysterectomies performed between January 2015 and March 2023 in Benha University Hospital. The NDVH group included 55 women. The TAH group included 62 women. Results: Both NDVH and TAH groups participants had statistically indifferent pre-operative mean hemoglobin levels, age, parity, associated comorbidities, previous pelvic and abdominal surgery involving cesarean sections, and comparable indications for hysterectomy(p>0.05), but statistically higher BMI, HBA1c preoperative serum level, and shorter preoperative hospital admission (days), all these items favoring the superiority NDVH group over the TAH group( p =0.0001). There were no statistical differences between groups as regrades operative room time, operative blood loss, intra-operative complications, removed uterine weight in grams, and the need for blood transfusion (p>0.05). While there were high statistical differences (p<0.0001) favoring outcomes of NDVH over TAH including the need for general anesthesia, wound complications percentage (1% vs 72%), shorter postoperative hospital stays, less consumption of analgesic and shorter duration needs for postoperative venous thromboembolic prophylaxis, earlier ambulation, earlier to pass flatus. Approximate charges of both procedures were encouraging the NDVH over TAH (p<0.0001). Conclusion: In morbidly obese women with non-prolapsed uteri, the NDVH should be the primary route for hysterectomy, as the NDVH results is better than the TAH results in all perioperative outcomes items.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139246228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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