Pub Date : 2024-01-19DOI: 10.21608/bmfj.2024.252222.1968
Hana Omar, Elham Mohamedy, Mohammed El-Saeed, Asmaa Mohamed
Background: Epilepsy is a common neurological disorder in adolescents, often associated with anxiety and depression, significantly impacting their quality of life (QoL). This study aimed to assess the QoL of adolescents with epilepsy receiving monotherapy or polytherapy and determine the influencing factors on their health related QoL. Methods: This comparative cross-sectional study included adolescent patients with epilepsy, aged 10-18 and with an average IQ of 90-110, from Benha University Hospital and Benha Children Hospital. Patients were divided into two groups: Group I (n = 50): Adolescents with epilepsy receiving mono antiepileptic therapy and Group II (n = 50): Adolescents with epilepsy receiving poly antiepileptic therapy. Results : The monotherapy group exhibited significantly lower generalized seizures and fit frequency compared to the polytherapy group. However, QoL domains did not significantly differ between the two groups. In both groups, age, weight, and height showed negative correlations with QoL scores. Conclusion: No significant differences in quality of life and social well-being between adolescents with epilepsy receiving mono antiepileptic therapy and those receiving poly antiepileptic therapy. Both treatment groups had comparable scores in the KIDSCREEN-27 domains.
{"title":"A Comparative Study between Mono Antiepileptic Therapy and Poly Antiepileptic Therapy regarding Quality of Life in Adolescents with Epilepsy","authors":"Hana Omar, Elham Mohamedy, Mohammed El-Saeed, Asmaa Mohamed","doi":"10.21608/bmfj.2024.252222.1968","DOIUrl":"https://doi.org/10.21608/bmfj.2024.252222.1968","url":null,"abstract":"Background: Epilepsy is a common neurological disorder in adolescents, often associated with anxiety and depression, significantly impacting their quality of life (QoL). This study aimed to assess the QoL of adolescents with epilepsy receiving monotherapy or polytherapy and determine the influencing factors on their health related QoL. Methods: This comparative cross-sectional study included adolescent patients with epilepsy, aged 10-18 and with an average IQ of 90-110, from Benha University Hospital and Benha Children Hospital. Patients were divided into two groups: Group I (n = 50): Adolescents with epilepsy receiving mono antiepileptic therapy and Group II (n = 50): Adolescents with epilepsy receiving poly antiepileptic therapy. Results : The monotherapy group exhibited significantly lower generalized seizures and fit frequency compared to the polytherapy group. However, QoL domains did not significantly differ between the two groups. In both groups, age, weight, and height showed negative correlations with QoL scores. Conclusion: No significant differences in quality of life and social well-being between adolescents with epilepsy receiving mono antiepileptic therapy and those receiving poly antiepileptic therapy. Both treatment groups had comparable scores in the KIDSCREEN-27 domains.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139612485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.21608/bmfj.2024.234196.1890
Essam El-Matbouly Saber, Hamdy Ahmed Abdou Elgazzar, Tarek Ateya, Sameh Galal Taher salem, Ahmed Mohamed Abdelbaky El Shabrawy
: Background: Thyroid eye disease is an autoimmune disorder of the retrobulbar tissue. Various treatment modalities are available as peribulbar steroid injection and orbital radiotherapy. Orbital decompression is needed when
{"title":"Orbital steroid injection versus orbital radiation therapy in treatment of active thyroid eye disease.","authors":"Essam El-Matbouly Saber, Hamdy Ahmed Abdou Elgazzar, Tarek Ateya, Sameh Galal Taher salem, Ahmed Mohamed Abdelbaky El Shabrawy","doi":"10.21608/bmfj.2024.234196.1890","DOIUrl":"https://doi.org/10.21608/bmfj.2024.234196.1890","url":null,"abstract":": Background: Thyroid eye disease is an autoimmune disorder of the retrobulbar tissue. Various treatment modalities are available as peribulbar steroid injection and orbital radiotherapy. Orbital decompression is needed when","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140504379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.21608/bmfj.2024.235710.1898
Ahmad Musallam, Khalid Elrabbat, Mohamed Tabl, Hager Allam
: Background: Acute myocardial infarction with multivessel disease represents a higher cardiovascular risk and revascularization strategy in such patients remains a subject of conflict. The aim of our study was to assess the potential benefit of complete revascularization as compared to culprit vessel only revascularization in ST-segment elevation myocardial infarction (STEMI) patients who has multivessel disease (MVD). Methods: The current study is a single center prospective study conducted on 150 Patients presented with acute ST-segment elevation myocardial infarction to emergency department (ED) and cardiac care unit (CCU) in Nasr City Hospital, and according to revascularization strategy, patients were divided into two groups; Group I: patients received complete revascularization before hospital discharge and Group II: patients receiving culprit-only revascularization. Results: There was significant lower MACE in group I (p<0.05). The occurrence of non-ST segment acute coronary syndrome (NSTE-ACS) as well as the need for ischemia-driven revascularization-were significantly lower in the complete revascularization group (p=0.028 & p=0.008), respectively. Conclusion: in STEMI patients with multivessel disease, complete revascularization-as compared to culprit-only revascularization strategy-reduced MACE and improved short-term outcome.
:背景：伴有多支血管疾病的急性心肌梗死具有较高的心血管风险，而此类患者的血管再通策略仍存在争议。我们的研究旨在评估对 ST 段抬高型心肌梗死（STEMI）患者进行完全血运重建与仅对罪魁祸首血管进行血运重建的潜在益处。方法：本研究是一项单中心前瞻性研究，对象是 150 名到纳斯尔市医院急诊科（ED）和心脏监护室（CCU）就诊的急性 ST 段抬高型心肌梗死患者，根据血管再通策略，患者被分为两组：第一组：出院前接受完全血管再通的患者；第二组：只接受罪魁祸首血管再通的患者。结果I 组患者的 MACE 明显较低（P<0.05）。完全血运重建组的非 ST 段急性冠脉综合征（NSTE-ACS）发生率和缺血驱动的血运重建需求分别显著降低（P=0.028 和 P=0.008）。结论：对于患有多血管疾病的 STEMI 患者，完全血管再通术与单纯罪魁祸首血管再通术策略相比，可降低 MACE 并改善短期预后。
{"title":"Complete Versus Culprit-Only Revascularization Strategies to Treat Multivessel Disease after Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction","authors":"Ahmad Musallam, Khalid Elrabbat, Mohamed Tabl, Hager Allam","doi":"10.21608/bmfj.2024.235710.1898","DOIUrl":"https://doi.org/10.21608/bmfj.2024.235710.1898","url":null,"abstract":": Background: Acute myocardial infarction with multivessel disease represents a higher cardiovascular risk and revascularization strategy in such patients remains a subject of conflict. The aim of our study was to assess the potential benefit of complete revascularization as compared to culprit vessel only revascularization in ST-segment elevation myocardial infarction (STEMI) patients who has multivessel disease (MVD). Methods: The current study is a single center prospective study conducted on 150 Patients presented with acute ST-segment elevation myocardial infarction to emergency department (ED) and cardiac care unit (CCU) in Nasr City Hospital, and according to revascularization strategy, patients were divided into two groups; Group I: patients received complete revascularization before hospital discharge and Group II: patients receiving culprit-only revascularization. Results: There was significant lower MACE in group I (p<0.05). The occurrence of non-ST segment acute coronary syndrome (NSTE-ACS) as well as the need for ischemia-driven revascularization-were significantly lower in the complete revascularization group (p=0.028 & p=0.008), respectively. Conclusion: in STEMI patients with multivessel disease, complete revascularization-as compared to culprit-only revascularization strategy-reduced MACE and improved short-term outcome.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"114 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139615422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.21608/bmfj.2024.225748.1867
Wafaa Metwally, Omayma K. Helal, Sherifa A.Morsy, Nessrine E.Ahmed
: Background: Pulmonary fibrosis (PF) is a chronic fibrotic lung disease. Lung parenchyma and architecture is destroyed, compliance is lost, and gas exchange is compromised in this debilitating condition that leads to respiratory failure. NAC is a precursor of L-cysteine that results in glutathione elevation biosynthesis. It acts directly as a scavenger of free radicals, especially oxygen radicals. This study aimed to evaluate the possible therapeutic effect of Adipose derived mesenchymal stem cells and N-acetylcysteine (NAC) on induced lung fibrosis in adult male albino rats. Methods: Ten rats were used to isolated adipose-derived stem cells and sixty rats were randomly divided into five groups. Group I (control group: 20 rats), Group II (affected group:10 rats), Group III (Adipose stem cell group: 10 rats), Group Iv (N-acetylcystiene group:10 rats) and Group v (Adipose stem cell + NAC group: 10 rats). Specimens taken and histological studies, immunohistochemical and morphometric study were performed. Results: Group II showed markedly thickened inter-alveolar septa with extensive cellular infiltration and many collapsed alveoli. There was massive lymphocytic infiltration around bronchiolar wall. There was a significant decrease (P<0.01) in collagen fibers accumulation in group III, IV and V compared with group II. There was a significant increased (P>0.01) in Ki67 expression in group III, IV & V compared to group I. Conclusion: This work concluded that each of N-acetylcysteine and Adipose-Derived Stem Cells can ameliorate bleomycin induced lung toxicity, but their co-administration can give better results. The use of adipose tissue-derived stem cells with N-acetylcysteine showed marked reduction in the Bleomycin toxicity and significant improvement of bleomycin induced lung fibrosis
{"title":"The Possible Therapeutic Effect of Adipose Derived Mesenchymal Stem Cells and N-Acetyl cysteine on Bleomycin Induced Lung Fibrosis in Adult Male Albino Rats: Histological and Immuno-histochemical Study","authors":"Wafaa Metwally, Omayma K. Helal, Sherifa A.Morsy, Nessrine E.Ahmed","doi":"10.21608/bmfj.2024.225748.1867","DOIUrl":"https://doi.org/10.21608/bmfj.2024.225748.1867","url":null,"abstract":": Background: Pulmonary fibrosis (PF) is a chronic fibrotic lung disease. Lung parenchyma and architecture is destroyed, compliance is lost, and gas exchange is compromised in this debilitating condition that leads to respiratory failure. NAC is a precursor of L-cysteine that results in glutathione elevation biosynthesis. It acts directly as a scavenger of free radicals, especially oxygen radicals. This study aimed to evaluate the possible therapeutic effect of Adipose derived mesenchymal stem cells and N-acetylcysteine (NAC) on induced lung fibrosis in adult male albino rats. Methods: Ten rats were used to isolated adipose-derived stem cells and sixty rats were randomly divided into five groups. Group I (control group: 20 rats), Group II (affected group:10 rats), Group III (Adipose stem cell group: 10 rats), Group Iv (N-acetylcystiene group:10 rats) and Group v (Adipose stem cell + NAC group: 10 rats). Specimens taken and histological studies, immunohistochemical and morphometric study were performed. Results: Group II showed markedly thickened inter-alveolar septa with extensive cellular infiltration and many collapsed alveoli. There was massive lymphocytic infiltration around bronchiolar wall. There was a significant decrease (P<0.01) in collagen fibers accumulation in group III, IV and V compared with group II. There was a significant increased (P>0.01) in Ki67 expression in group III, IV & V compared to group I. Conclusion: This work concluded that each of N-acetylcysteine and Adipose-Derived Stem Cells can ameliorate bleomycin induced lung toxicity, but their co-administration can give better results. The use of adipose tissue-derived stem cells with N-acetylcysteine showed marked reduction in the Bleomycin toxicity and significant improvement of bleomycin induced lung fibrosis","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"103 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139614514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.21608/bmfj.2024.246793.1945
Mostafa Abd Elwahab, El-sayed A. Abd El-Mabood, Ahmed Abd Elsamai, Mohammed A. Waly
: Background: Varicose veins are a common vascular disorder, often causing cosmetic concerns and decreased quality of life. Radiofrequency ablation has emerged as an effective intervention for primary varicose veins, addressing both medical and cosmetic aspects. This study aimed to evaluate the cosmetic effect of radio frequency ablation of primary varicose veins including quality of life (QoL). Patients and methods: This prospective interventional study was conducted on 40 patients diagnosed with primary varicose veins. Radiofrequency ablation was performed, and patients were assessed using various parameters, including CEAP classification, visual analogue pain scale, and quality of life measures. Results: The study included individuals with a mean age of 33.13 ± 5.5, comprising 35% males and 65% females. Intraoperative and post-procedure Pain scores (VAS) exhibited highly significant differences. The mean hospital stay was 14.00 ± 7.00 hours, the return to normal activity took 4.27 ± 1.31 days, and the return to work required 7.10 ± 1.83 days. Significant differences were observed between Preoperative and Post procedure in terms of the QoL parameter. Strong significant correlations between QoL parameter and age, CEAP, VDS, and VAS were evident in univariate and multivariate correlation regression analyses. Conclusions: Radiofrequency technologies are, effective and safe treatments for truncal venous reflux with less side effects. Radio Frequency Ablation treatments have typically short post-procedural recovery times facilitating early return to work and normal activity.
{"title":"Evaluation of Cosmetic Effect of Radio Frequency Ablation of Primary Varicose Veins","authors":"Mostafa Abd Elwahab, El-sayed A. Abd El-Mabood, Ahmed Abd Elsamai, Mohammed A. Waly","doi":"10.21608/bmfj.2024.246793.1945","DOIUrl":"https://doi.org/10.21608/bmfj.2024.246793.1945","url":null,"abstract":": Background: Varicose veins are a common vascular disorder, often causing cosmetic concerns and decreased quality of life. Radiofrequency ablation has emerged as an effective intervention for primary varicose veins, addressing both medical and cosmetic aspects. This study aimed to evaluate the cosmetic effect of radio frequency ablation of primary varicose veins including quality of life (QoL). Patients and methods: This prospective interventional study was conducted on 40 patients diagnosed with primary varicose veins. Radiofrequency ablation was performed, and patients were assessed using various parameters, including CEAP classification, visual analogue pain scale, and quality of life measures. Results: The study included individuals with a mean age of 33.13 ± 5.5, comprising 35% males and 65% females. Intraoperative and post-procedure Pain scores (VAS) exhibited highly significant differences. The mean hospital stay was 14.00 ± 7.00 hours, the return to normal activity took 4.27 ± 1.31 days, and the return to work required 7.10 ± 1.83 days. Significant differences were observed between Preoperative and Post procedure in terms of the QoL parameter. Strong significant correlations between QoL parameter and age, CEAP, VDS, and VAS were evident in univariate and multivariate correlation regression analyses. Conclusions: Radiofrequency technologies are, effective and safe treatments for truncal venous reflux with less side effects. Radio Frequency Ablation treatments have typically short post-procedural recovery times facilitating early return to work and normal activity.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"121 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139613886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.21608/bmfj.2024.115274.1526
W. Afify, Mohamed Selim, Asmaa Alfallah, Ahmed Abdallah
: Background: Nephrotic syndrome (NS) is one of the most common chronic renal diseases in children, characterized by selective proteinuria, hypoalbuminemia, hyperlipidemia, and edema. This study aimed to assess the level of serum immune globulin E (IgE) in children with idiopathic nephrotic syndrome (INS) as a marker for response to therapy. Methods: This prospective study was conducted in the Pediatric Department, Benha University Hospital. The study consisted of two groups: Group I: Fifty children suffering from idiopathic nephrotic syndrome treated with corticosteroid. Group II: Fifteen healthy children as a control group. All included children were subjected to full history taking, complete clinical examination, and laboratory assessment as complete blood count (CBC), absolute eosinophilic count, serum urea & creatinine, serum level of IgE, serum electrolytes, and 24 h’s protein in urine. Results: About three-quarters of group I were steroid sensitive (72.0%), and one-quarter were steroid-resistant (28.0%), median serum IgE was significantly higher (p= 0.001) in group I (275.55) than group II (100.5). Median serum IgE was significantly higher (p= 0.001) in the steroid-resistant group (911.85) than the steroid-sensitive (164.5). ROC analysis was done for differentiating between nephrotic patients and controls. For IgE, it revealed a significant area under curve (AUC) of 0.788. Conclusion: Significantly higher serum IgE levels were associated with nephrotic syndrome and more prominently in patients with steroid-resistant nephrotic syndrome (SRNS).
{"title":"Serum IgE level in children with Idiopathic Nephrotic Syndrome","authors":"W. Afify, Mohamed Selim, Asmaa Alfallah, Ahmed Abdallah","doi":"10.21608/bmfj.2024.115274.1526","DOIUrl":"https://doi.org/10.21608/bmfj.2024.115274.1526","url":null,"abstract":": Background: Nephrotic syndrome (NS) is one of the most common chronic renal diseases in children, characterized by selective proteinuria, hypoalbuminemia, hyperlipidemia, and edema. This study aimed to assess the level of serum immune globulin E (IgE) in children with idiopathic nephrotic syndrome (INS) as a marker for response to therapy. Methods: This prospective study was conducted in the Pediatric Department, Benha University Hospital. The study consisted of two groups: Group I: Fifty children suffering from idiopathic nephrotic syndrome treated with corticosteroid. Group II: Fifteen healthy children as a control group. All included children were subjected to full history taking, complete clinical examination, and laboratory assessment as complete blood count (CBC), absolute eosinophilic count, serum urea & creatinine, serum level of IgE, serum electrolytes, and 24 h’s protein in urine. Results: About three-quarters of group I were steroid sensitive (72.0%), and one-quarter were steroid-resistant (28.0%), median serum IgE was significantly higher (p= 0.001) in group I (275.55) than group II (100.5). Median serum IgE was significantly higher (p= 0.001) in the steroid-resistant group (911.85) than the steroid-sensitive (164.5). ROC analysis was done for differentiating between nephrotic patients and controls. For IgE, it revealed a significant area under curve (AUC) of 0.788. Conclusion: Significantly higher serum IgE levels were associated with nephrotic syndrome and more prominently in patients with steroid-resistant nephrotic syndrome (SRNS).","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"41 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.21608/bmfj.2024.220443.1847
Eslam Shaboob, Basem Aglan, Ahmed Abdel Aziz Ahmed, Amany Fekry
: Background: Blood transfusion is a critical intervention in the management of patients with severe bleeding. However, the optimal ratio of blood products to be transfused remains a topic of debate. Aim: to evaluate the outcomes of using a 1:1:1 blood transfusion ratio in patients with critical bleeding and compare its effectiveness and safety with other ratios. Patients and Methods: patients admitted to the intensive care unit (ICU) at Benha University hospitals due to critical bleeding were included in this observational study. Results: The mean age of the patients was 41 ± 14 years, with equal gender distribution. Non-traumatic causes accounted for the majority (66%) of hemorrhagic shock cases. The analysis showed no significant differences in age, gender, or cause of hemorrhagic shock when classifying patients based on 24-hour mortality. However, non-survivors had significantly higher shock index values and longer hospital stays compared to survivors. When classifying patients based on 30-day mortality, non-survivors had a higher proportion of traumatic causes and received more red blood cell transfusions than survivors. There were positive correlations between the length of stay in the intensive care unit and blood product administration (red blood cells, fresh frozen plasma, and cryoprecipitate), as well as the shock index. Conclusion: the study highlights the importance of the shock index as a predictor of mortality in hemorrhagic shock patients. It also emphasizes the impact of factors such as shock severity, blood product administration, and the nature of the underlying cause on patient outcomes.
{"title":"Outcome of 1:1:1 Transfusion Ratio of Blood Products in Critical Bleeders Either Traumatic, Medical or Surgical","authors":"Eslam Shaboob, Basem Aglan, Ahmed Abdel Aziz Ahmed, Amany Fekry","doi":"10.21608/bmfj.2024.220443.1847","DOIUrl":"https://doi.org/10.21608/bmfj.2024.220443.1847","url":null,"abstract":": Background: Blood transfusion is a critical intervention in the management of patients with severe bleeding. However, the optimal ratio of blood products to be transfused remains a topic of debate. Aim: to evaluate the outcomes of using a 1:1:1 blood transfusion ratio in patients with critical bleeding and compare its effectiveness and safety with other ratios. Patients and Methods: patients admitted to the intensive care unit (ICU) at Benha University hospitals due to critical bleeding were included in this observational study. Results: The mean age of the patients was 41 ± 14 years, with equal gender distribution. Non-traumatic causes accounted for the majority (66%) of hemorrhagic shock cases. The analysis showed no significant differences in age, gender, or cause of hemorrhagic shock when classifying patients based on 24-hour mortality. However, non-survivors had significantly higher shock index values and longer hospital stays compared to survivors. When classifying patients based on 30-day mortality, non-survivors had a higher proportion of traumatic causes and received more red blood cell transfusions than survivors. There were positive correlations between the length of stay in the intensive care unit and blood product administration (red blood cells, fresh frozen plasma, and cryoprecipitate), as well as the shock index. Conclusion: the study highlights the importance of the shock index as a predictor of mortality in hemorrhagic shock patients. It also emphasizes the impact of factors such as shock severity, blood product administration, and the nature of the underlying cause on patient outcomes.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"45 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.21608/bmfj.2024.175374.1711
A. Elshazly, Neama M Taha, Asmaa Hussein, N. Sarg
: Background: Toxic effects on the tongue caused by Tacrolimus remains a major problem. Therefore, the aim of this research was to evaluate the potential therapeutic bone marrow-derived mesenchymal stem cells (MSCs) and platelet rich plasma (PRP) impact on tongue of albino rat. Materials and Methods: 40 Albino male rats were divided into four equal groups. Group I (control group) received no treatment. Group II received daily subcutaneous injections of 1 mg/kg/day of Tacrolimus for 30 days. Group III received Tacrolimus for 30 days then a single PRP injection. Group IV received Tacrolimus for 30 days then a single injection of MSCs. In all groups the rats were scarified after sixty days from the beginning of the experiment. For demonstration of the collagen fibers, tongue sections were stained with Mallory Trichrome and were stained with Hematoxylin and Eosin for histological analysis. Electron microscopic scans were used in this study and immunohistochemistry using anti-PCNA primary antibody were used to examine the tongue. Results: Histological and immunohistochemical examination of Tacrolimus group tongues showed poorly defined filiform papillae, some epithelial cells appeared degenerated with pyknotic nuclei, however tongue sections of Gr. II and Gr. IV showed marked tongue histological structure improvement and up regulated expression of PCNA, compared to the Gr. II. Scanning electron microscope supported these results. Conclusion: MSCs and PRP have good effects in reduction of the toxic effect of Tacrolimus administration on the rat tongue with insignificant difference between the two methods.
{"title":"Ameliorating the toxic effect of the immunosuppressive drugs (Tacrolimus) on male Albino rat tongue by mesenchymal stem cells versus platelet rich plasma (histological, immunohistochemical and scanning electron microscopic study","authors":"A. Elshazly, Neama M Taha, Asmaa Hussein, N. Sarg","doi":"10.21608/bmfj.2024.175374.1711","DOIUrl":"https://doi.org/10.21608/bmfj.2024.175374.1711","url":null,"abstract":": Background: Toxic effects on the tongue caused by Tacrolimus remains a major problem. Therefore, the aim of this research was to evaluate the potential therapeutic bone marrow-derived mesenchymal stem cells (MSCs) and platelet rich plasma (PRP) impact on tongue of albino rat. Materials and Methods: 40 Albino male rats were divided into four equal groups. Group I (control group) received no treatment. Group II received daily subcutaneous injections of 1 mg/kg/day of Tacrolimus for 30 days. Group III received Tacrolimus for 30 days then a single PRP injection. Group IV received Tacrolimus for 30 days then a single injection of MSCs. In all groups the rats were scarified after sixty days from the beginning of the experiment. For demonstration of the collagen fibers, tongue sections were stained with Mallory Trichrome and were stained with Hematoxylin and Eosin for histological analysis. Electron microscopic scans were used in this study and immunohistochemistry using anti-PCNA primary antibody were used to examine the tongue. Results: Histological and immunohistochemical examination of Tacrolimus group tongues showed poorly defined filiform papillae, some epithelial cells appeared degenerated with pyknotic nuclei, however tongue sections of Gr. II and Gr. IV showed marked tongue histological structure improvement and up regulated expression of PCNA, compared to the Gr. II. Scanning electron microscope supported these results. Conclusion: MSCs and PRP have good effects in reduction of the toxic effect of Tacrolimus administration on the rat tongue with insignificant difference between the two methods.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"40 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-06DOI: 10.21608/bmfj.2023.249907.1958
Mohamed Abdel-Latif, Hassan Elsoueni, Gamal Saleh, Ahmed Wahdan, amr rashed
Background: Breast cancer is a significant public health concern, and early detection of breast lesions is crucial for improved patient outcomes. Various screening methods, including mammography and ultrasound, have been employed, but their limitations necessitate the exploration of alternative diagnostic tools. This study aimed to evaluate the diagnostic efficacy of the Breast light device during clinical breast examination (CBE) in comparison of mammography and Breast ultrasound in the detection of breast lesions (BLs). Methods: This prospective multi-centric study was conducted, involving 300 female patients from outpatient breast clinics. The patients underwent clinical breast examination and were examined using the Breast Light device. Additionally, bilateral breast ultrasound or bilateral breast sono-mammography were performed. Results : The data showed that the Breast Light device exhibited a sensitivity of 72.6% and 83.8% for detecting benign and malignant breast masses when compared to ultrasound, with a specificity of 98.6% and an accuracy of 86.6%. When compared to sono-mammography, the sensitivity was 72.9% and 89.5%, with a specificity of 92.5% and an accuracy of 85.3%. Conclusion: The Breast Light device demonstrates promise as an adjunct tool for detecting breast lesions, with high specificity. It can play a valuable role in conjunction with traditional imaging methods, particularly in settings where advanced equipment may be limited.
背景：乳腺癌是一个重大的公共卫生问题，早期发现乳腺病变对改善患者预后至关重要。目前已采用包括乳房 X 线照相术和超声波在内的各种筛查方法，但由于其局限性，有必要探索其他诊断工具。本研究旨在评估在临床乳房检查（CBE）过程中，乳腺灯装置与乳腺 X 线照相术和乳腺超声波在检测乳腺病变（BLs）方面的诊断效果比较。研究方法这项前瞻性多中心研究涉及乳腺门诊的 300 名女性患者。患者接受了临床乳房检查，并使用乳腺灯设备进行了检查。此外，还进行了双侧乳腺超声波检查或双侧乳腺超声乳腺造影检查。结果：数据显示，与超声波检查相比，乳腺灯设备检测乳腺良性和恶性肿块的灵敏度分别为 72.6% 和 83.8%，特异性为 98.6%，准确性为 86.6%。与超声乳腺造影相比，灵敏度分别为 72.9% 和 89.5%，特异性为 92.5%，准确性为 85.3%。结论乳腺灯设备作为检测乳腺病变的辅助工具，具有很高的特异性。它可以与传统成像方法结合使用，尤其是在先进设备有限的情况下，发挥重要作用。
{"title":"Evaluation of Breast Light Device Efficacy in Detection of Breast Lesions in Comparison with Breast Sono-Mammography","authors":"Mohamed Abdel-Latif, Hassan Elsoueni, Gamal Saleh, Ahmed Wahdan, amr rashed","doi":"10.21608/bmfj.2023.249907.1958","DOIUrl":"https://doi.org/10.21608/bmfj.2023.249907.1958","url":null,"abstract":"Background: Breast cancer is a significant public health concern, and early detection of breast lesions is crucial for improved patient outcomes. Various screening methods, including mammography and ultrasound, have been employed, but their limitations necessitate the exploration of alternative diagnostic tools. This study aimed to evaluate the diagnostic efficacy of the Breast light device during clinical breast examination (CBE) in comparison of mammography and Breast ultrasound in the detection of breast lesions (BLs). Methods: This prospective multi-centric study was conducted, involving 300 female patients from outpatient breast clinics. The patients underwent clinical breast examination and were examined using the Breast Light device. Additionally, bilateral breast ultrasound or bilateral breast sono-mammography were performed. Results : The data showed that the Breast Light device exhibited a sensitivity of 72.6% and 83.8% for detecting benign and malignant breast masses when compared to ultrasound, with a specificity of 98.6% and an accuracy of 86.6%. When compared to sono-mammography, the sensitivity was 72.9% and 89.5%, with a specificity of 92.5% and an accuracy of 85.3%. Conclusion: The Breast Light device demonstrates promise as an adjunct tool for detecting breast lesions, with high specificity. It can play a valuable role in conjunction with traditional imaging methods, particularly in settings where advanced equipment may be limited.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"31 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-06DOI: 10.21608/bmfj.2023.252371.1967
Ahmed Bendary, Islam Saad Abdelmaged, Ahmed Mohamed, Mahmoud Abdelmoneum
Background: Fragmented QRS (fQRS) on the ECG is a straightforward, affordable, and widely accessible indicator of myocardial fibrosis and scarring. Aim: This study aimed to assess the predictive value of (fQRS) in diagnosing myocardial ischemia. It evaluated its incremental prognostic significance in patients having single-photon emission computed tomography (SPECT) for exercise-induced myocardial ischemia. Methods: This observational case-control research was executed on 206 patients who underwent exercise myocardial perfusion SPECT for suspected stable chronic CAD. All patients were subjected to demographic, clinical, and laboratory data, electrocardiography, echocardiography, and SPECT myocardial perfusion imaging. The existence of fQRS was determined based on electrocardiographic criteria. Multivariate logistic regression analysis was applied to predict myocardial ischemia, and the incremental prognostic value of fQRS was determined utilizing hierarchical regression analysis. Results: The patients had a mean age of 53 ±10 years, and more than one-quarter (28.2%) had fQRS. Patients with myocardial ischemia (Group I) had a greater prevalence of fQRS than the control group fQRS (42.3% vs. 23.4%, P = 0.009). In multivariate analysis,
{"title":"The Predictive Value of Fragmented QRS Complex in Diagnosis of Myocardial Ischemia","authors":"Ahmed Bendary, Islam Saad Abdelmaged, Ahmed Mohamed, Mahmoud Abdelmoneum","doi":"10.21608/bmfj.2023.252371.1967","DOIUrl":"https://doi.org/10.21608/bmfj.2023.252371.1967","url":null,"abstract":"Background: Fragmented QRS (fQRS) on the ECG is a straightforward, affordable, and widely accessible indicator of myocardial fibrosis and scarring. Aim: This study aimed to assess the predictive value of (fQRS) in diagnosing myocardial ischemia. It evaluated its incremental prognostic significance in patients having single-photon emission computed tomography (SPECT) for exercise-induced myocardial ischemia. Methods: This observational case-control research was executed on 206 patients who underwent exercise myocardial perfusion SPECT for suspected stable chronic CAD. All patients were subjected to demographic, clinical, and laboratory data, electrocardiography, echocardiography, and SPECT myocardial perfusion imaging. The existence of fQRS was determined based on electrocardiographic criteria. Multivariate logistic regression analysis was applied to predict myocardial ischemia, and the incremental prognostic value of fQRS was determined utilizing hierarchical regression analysis. Results: The patients had a mean age of 53 ±10 years, and more than one-quarter (28.2%) had fQRS. Patients with myocardial ischemia (Group I) had a greater prevalence of fQRS than the control group fQRS (42.3% vs. 23.4%, P = 0.009). In multivariate analysis,","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"33 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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