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Accuracy and sensitivity of RIPASA score Versus Alvarado score in diagnosis of acute appendicitis. RIPASA 评分与 Alvarado 评分在诊断急性阑尾炎方面的准确性和敏感性。
Pub Date : 2024-03-09 DOI: 10.21608/bmfj.2024.249370.1954
Mohamed I Abourizk, Emad Abdelrahman, A. Zidan, Mena Armanyous, Mohammed Fadey
Background: Acute appendicitis (AA) is a prevalent emergency involving the abdomen that necessitates prompt attention and has a significant risk of negative appendectomy. Objective: To compare the sensitivity and diagnostic accuracy of RIPASA and Alverado scoring systems of acute appendicitis in correlation with intra-operative findings. Patients and Methods: This prospective study included 193 patients with acute appendicitis All items of RIPASA score and Alverado score were reported with a cut off value of 7.5 for RIPASA and 7 for Alverado and correlated to the postoperative histopathology. Results: The mean age of the included patients was 33.25 ± 11.39 years. The histopathological outcome in correlation to RIPASA score 84% of cases were true positive while 8.3% were true negative while the correlation with Alverado score 73% of cases were truly positive and 12.4% were truly negative. There was a statistically significant difference between both RIPASA and Alverado scores where RIPASA score was significantly more sensitive and accurate than Alverado with Higher NPV while Alverado score was more specific. Conclusion: According to the current results, RIPASA score is a reliable, feasible for Diagnosis of AA with high sensitivity, positive predictive value, and Diagnostic accuracy in comparison with the Alverado score.
背景:急性阑尾炎(AA)是一种常见的腹部急症,需要及时治疗,而且阑尾切除术的风险很大。目的比较急性阑尾炎 RIPASA 和 Alverado 评分系统的敏感性和诊断准确性与术中发现的相关性。患者和方法:这项前瞻性研究纳入了 193 名急性阑尾炎患者,报告了 RIPASA 评分和 Alverado 评分的所有项目,RIPASA 评分的临界值为 7.5,Alverado 评分的临界值为 7,并与术后组织病理学结果相关联。结果:纳入患者的平均年龄为(33.25 ± 11.39)岁。与 RIPASA 评分相关的组织病理学结果中,84% 为真正阳性,8.3% 为真正阴性;与 Alverado 评分相关的组织病理学结果中,73% 为真正阳性,12.4% 为真正阴性。RIPASA 评分和 Alverado 评分在统计学上有显著差异,RIPASA 评分的敏感性和准确性明显高于 Alverado 评分,NPV 更高,而 Alverado 评分的特异性更高。结论根据目前的研究结果,RIPASA 评分与 Alverado 评分相比,具有较高的灵敏度、阳性预测值和诊断准确性,是一种可靠、可行的 AA 诊断方法。
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引用次数: 0
Hematological Impact of COVID-19: Anemia in Post-COVID COVID-19 的血液学影响:COVID 后贫血
Pub Date : 2024-03-09 DOI: 10.21608/bmfj.2023.244728.1939
Taher Abdel-Aziz, Ghada Nabil Abd El Aziz, Mai Fawzy, Nagwa Ibrahim EL Dosoky, Hanaa Iraqi Ahmed Hegab, Ismail Dahshan
Purpose: This study’s purpose was to assess the relationship between COVID-19 and hematological variations on admission and 6 months after discharge. Patients and Methods: In a prospective observational study at Kafr Shokr Specialized Hospital from September 2021 to September 2022, 292 adult patients with PCR-confirmed COVID-19 were categorized into hospitalized and non-hospitalized groups. Comprehensive clinical evaluations, including blood assessments-were conducted. The hospitalized patients were re-evaluated for anemia six months after discharge. Results: Hemoglobin (Hb) levels were significantly higher in the non-hospitalized group, with a mean of 14.13 g/dL, compared to the hospitalized group with 12.43 g/dL (p < 0.001). Anemia affected 18.005% of the non-hospitalized group, compared to 45.3% of the hospitalized group. At 6-month follow-up, hospitalized patients showed a decrease in Hb levels and platelet counts and an increase in white blood cell counts. Logistic regression identified baseline anemia, lower Hb, and reduced MCH levels as predictors for post-COVID anemia. Conclusion: The study revealed that COVID-19 severity was associated with anemia, which persisted and increased in prevalence six months post-infection. Baseline anemia, Hb, and MCH levels emerged as crucial predictors for post-COVID anemia, emphasizing the need for continuous hematological monitoring in COVID-19 survivors.
目的:本研究旨在评估 COVID-19 与入院时和出院后 6 个月的血液学变化之间的关系。患者和方法2021 年 9 月至 2022 年 9 月,Kafr Shokr 专科医院开展了一项前瞻性观察研究,将 292 名经 PCR 证实患有 COVID-19 的成年患者分为住院组和非住院组。进行了全面的临床评估,包括血液评估。住院患者在出院六个月后重新进行贫血评估。结果显示非住院组患者的血红蛋白(Hb)水平明显较高,平均为 14.13 g/dL,而住院组为 12.43 g/dL(P < 0.001)。非住院组中有 18.005% 的人患有贫血,而住院组中有 45.3% 的人患有贫血。在 6 个月的随访中,住院患者的 Hb 水平和血小板计数下降,白细胞计数上升。逻辑回归确定基线贫血、较低的 Hb 和 MCH 水平降低是导致 COVID 后贫血的预测因素。结论研究表明,COVID-19 的严重程度与贫血有关,贫血在感染后 6 个月持续存在,且发病率有所上升。基线贫血、血红蛋白和 MCH 水平是预测 COVID-19 后贫血的关键因素,这强调了对 COVID-19 幸存者进行持续血液监测的必要性。
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引用次数: 0
Assessment of Left Ventricular Deformation in Rheumatic Mitral Stenosis Patients (Speckle Tracking Study) 风湿性二尖瓣狭窄患者左心室变形评估(斑点追踪研究)
Pub Date : 2024-03-08 DOI: 10.21608/bmfj.2024.267225.2012
Al.Shimaa Sabry, Hesham Rashid, Mohamed El-Khouly, Eman El-Keshk
Objectives: to utilize speckle tracking echocardiography to assess the left ventricular (LV) systolic function in rheumatic mitral stenosis (MS) patients. Methods: 100 patients were evaluated with pure rheumatic MS who were contrasted with 50 healthy individuals of matched age, gender, and risk factors. We assessed the mitral valve area (MVA) utilizing planimetry and the mean transmitral pressure gradient; then based on MVA, the patients were split into two groups. MS patients in the first group were classified as having severe symptoms, while patients in the second group had moderate symptoms. Speckle tracking echocardiography was employed to determine LV subclinical systolic dysfunction. Results: Regarding clinical data and LVEF, no statistically significant distinctions were seen between the groups. Global LV longitudinal strain was significantly diminished in MS patients. Both global basal and mid segments strain were significantly diminished in MS patients (P <0.001). On the contrary, with relation to the global apical strain, no statistically significant distinction existed between the groups under investigation (P=0.96). The global basal, mid, and apical longitudinal strain exhibited a significant negative relationship with the mean transmitral pressure gradient. Conclusions: MS patients
目的:利用斑点追踪超声心动图评估风湿性二尖瓣狭窄(MS)患者的左心室收缩功能。方法:评估 100 名单纯风湿性二尖瓣狭窄(MS)患者,并将其与 50 名年龄、性别和危险因素相匹配的健康人进行对比。我们利用平面测量法和平均二尖瓣压力梯度评估二尖瓣面积(MVA),然后根据二尖瓣面积将患者分为两组。第一组多发性硬化症患者的症状为重度,第二组患者的症状为中度。采用斑点追踪超声心动图确定左心室亚临床收缩功能障碍。结果就临床数据和 LVEF 而言,两组之间的差异无统计学意义。多发性硬化症患者的整体左心室纵向应变明显减少。多发性硬化症患者的整体基底段和中段应变均明显降低(P <0.001)。相反,就整体心尖应变而言,调查组之间不存在统计学意义上的显著差异(P=0.96)。整体基底、中部和心尖纵向应变与平均透射压梯度呈显著负相关。结论多发性硬化症患者
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引用次数: 0
Impact of Sex and Gender Differences on Cardiovascular Risk Factors and Cardiovascular Complications in Diabetic Patients in Benha City, Egypt: A Hospital-Based Cross-Sectional Study 埃及贝纳市糖尿病患者心血管风险因素和心血管并发症的性别差异影响:一项基于医院的横断面研究
Pub Date : 2024-03-05 DOI: 10.21608/bmfj.2024.253857.1976
Amira M. El Sayed, Walaa-Eldeen M. Ibrahim, Ayman M. Elbadawy, Sally H. Mohammed, Rasha O. Abd ElMoneim
Background: There is growing evidence that gender and sex differences matter when it comes to many diseases' epidemiology, etiology, treatment, and results; however, non-communicable diseases seem to be more affected by these differences. Aims : to investigate the effects of gender and sex variations on cardiovascular disease (CVD) risk factors and various diabetes CVD sequelae. Methods: A total of 1000 type 2 diabetic patients (T2DM), ages 35 to 75, were included in this cross-sectional study: 500 males and 500 females. Results: Diabetes duration (13.34 ± 4.64 vs. 11.99 ± 5.04 ys), HbA 1C (7.5 ± 0.55 vs. 7.28 ± 0.48 %) were considerably higher in females than males (p < 0.001). Waist circumference, smoking, and uric acid were significantly lower in females. BMI, total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), triglycerides (TG), and family history of premature CVD were significantly higher in females. Heart failure, stroke, retinopathy, ischemic heart disease, and peripheral arterial disease were insignificantly different between both groups. While dysrhythmia, chronic kidney disease (CKD), and peripheral neuropathy (PN) were significantly lower in females than males. Conclusions: Among Egyptian diabetic patients, Diabetes duration, family history of premature CVD, BMI, HbA 1C, TC, LDL-C, HDL-C, and TG were considerably higher in females than males. However, Waist circumference, smoking, and uric acid were significantly lower in females. Males with T2DM may be more susceptible to PN and nephropathy, whereas females with the same disease may have a lower risk of arrhythmias than men with the same disease.
背景:越来越多的证据表明,性别差异对许多疾病的流行病学、病因学、治疗和结果都有影响;然而,非传染性疾病似乎更受这些差异的影响。目的:研究性别差异对心血管疾病(CVD)风险因素和各种糖尿病 CVD 后遗症的影响。方法:这项横断面研究共纳入 1000 名年龄在 35 岁至 75 岁之间的 2 型糖尿病患者(T2DM):其中男性 500 人,女性 500 人。研究结果女性的糖尿病病程(13.34 ± 4.64 年 vs. 11.99 ± 5.04 年)、HbA 1C (7.5 ± 0.55% vs. 7.28 ± 0.48%)明显高于男性(P < 0.001)。女性的腰围、吸烟率和尿酸显著低于男性。女性的体重指数(BMI)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、甘油三酯(TG)和早发心血管疾病家族史明显高于男性。心力衰竭、中风、视网膜病变、缺血性心脏病和外周动脉疾病在两组之间的差异不大。而女性心律失常、慢性肾病和周围神经病变的发病率则明显低于男性。结论在埃及糖尿病患者中,女性的糖尿病病程、早发心血管疾病家族史、体重指数、HbA 1C、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和总胆固醇均明显高于男性。然而,女性的腰围、吸烟和尿酸明显低于男性。患有 T2DM 的男性可能更容易发生 PN 和肾病,而患有相同疾病的女性发生心律失常的风险可能低于男性。
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引用次数: 0
Utility of sequential nerve conduction studies and electromyography in early guillain barre syndrome; a clinical and electrophysiological study 序列神经传导研究和肌电图在早期格林巴利综合征中的应用;一项临床和电生理学研究
Pub Date : 2024-03-05 DOI: 10.21608/bmfj.2024.248828.1950
Aya Elshebl, Khaled Sallam, Ayat Allah Hussein, S. Kasem
: Background: Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis. Nerve conduction studies (NCS) play an important role in GBS diagnosis and subtype classification but diagnosis of GBS in the very early stage may be challenging. The clinical presentation, course, the clinical recovery and outcome of GBS all are variable. Aim of the work: Our aim was to evaluate the clinical and neurophysiological findings of early Guillain-Barré syndrome and to identify factors that influence outcome. Patient and Methods: we prospectively recruited patients from clinical neurophysiology unit in Kasr Al –Ainy Hospitals and Benha University Hospitals, aimed to evaluate the clinical and neurophysiological findings of early GBS and to identify factors that influence outcome. The studied sample was 17 patients of GBS fulfilling its criteria . Results: majority of the patients were AIDP (76.5%), while (23.5 %) of patients were axonal (either AMAN or AMSAN) . Predictors of poor outcome were old age, cranial nerve dysfunction and respiratory muscle dysfunction. Conclusion: Electro-physiological studies play an important role in the early detection of GBS. Early diagnosis of GBS is essential as early treatment decreases the duration of GBS and its severity. Clinical presentation, course and outcome of GBS can be variable among patients.
:背景:吉兰-巴雷综合征(GBS)是急性弛缓性麻痹最常见的病因。神经传导检查(NCS)在 GBS 诊断和亚型分类中起着重要作用,但 GBS 的早期诊断可能具有挑战性。GBS 的临床表现、病程、临床恢复和预后均不尽相同。工作目标我们的目的是评估早期格林-巴利综合征的临床和神经电生理结果,并确定影响预后的因素。患者和方法:我们从 Kasr Al -Ainy 医院和本哈大学医院的临床神经电生理科招募了前瞻性患者,旨在评估早期格林-巴利综合征的临床和神经电生理检查结果,并确定影响结果的因素。研究样本为符合标准的 17 名 GBS 患者。结果:大多数患者为 AIDP(76.5%),23.5% 的患者为轴索型(AMAN 或 AMSAN)。预示不良预后的因素包括高龄、颅神经功能障碍和呼吸肌功能障碍。结论电生理研究在早期发现 GBS 方面发挥着重要作用。早期诊断 GBS 至关重要,因为早期治疗可缩短 GBS 的持续时间并减轻其严重程度。不同患者的 GBS 临床表现、病程和预后可能各不相同。
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引用次数: 0
The possible therapeutic role of mesenchymal stem cells of bone marrow in treatment of diabetic nephropathy in Albino rats. 骨髓间充质干细胞在治疗白化大鼠糖尿病肾病中的可能治疗作用。
Pub Date : 2024-03-04 DOI: 10.21608/bmfj.2024.266022.2007
Hind Ahmed, Saleh Sayed Edris, N. Sarg, Essam Mohamad Mhlab, H. Mousa
Background : Uncontrolled diabetes mellitus plays a significant role in the development of diabetic nephropathy. Aim: This study was performed to assess the pathological effect of diabetes on the kidney, the possible improvement of diabetic nephropathy by Insulin, and the therapeutic effect of mesenchymal stem cells. Methods: 50 healthy albino adult male rats were subdivided into two main groups, Group 1: control group (8 rats). Group 2: 42 rats were given a single intraperitoneal injection of streptozotocin (80 mg/kg). After 6 weeks, confirming diabetic nephropathy, rats were dispersed into 3 groups as follows; Group (2a): diabetic nephropathic untreated rats, Group (2b) was given insulin glargine 6 IU/24 hours, for 6 weeks and Group (2c) was received MSCs in intravenous injection (10 6 cells) per rat once. After sacrificing rats at the end of the experiment, blood sampling was done for laboratory analysis of serum urea, and creatinine. Kidney samples were prepared for light and electron microscopic examination. Results: Diabetic rats showed altered biochemical and histological changes which are dilated filtration space, focal lytic (degenerated) areas, and congested blood capillaries were observed in the diabetic group. Disfigurement of the renal tubules, with vacuolated cytoplasm in the insulin group while, normal appearance with mild increase in the Bowman's space in the MSCs group, with significant ameliorative effects on renal function. Conclusion: Treatment with insulin and MSCs showed improved histological and biochemical parameters in the kidneys of diabetic rats.
背景:未得到控制的糖尿病在糖尿病肾病的发展中起着重要作用。目的:本研究旨在评估糖尿病对肾脏的病理影响、胰岛素改善糖尿病肾病的可能性以及间充质干细胞的治疗效果。方法:将 50 只健康的白化成年雄性大鼠分成两大组,第一组:对照组(8 只)。第 2 组:42 只大鼠腹腔注射一次链脲佐菌素(80 毫克/千克)。6 周后,确诊为糖尿病肾病的大鼠被分散成以下 3 组:组(2a):未经治疗的糖尿病肾病大鼠,组(2b)给予格列卫胰岛素 6 IU/24 小时,持续 6 周,组(2c)接受间充质干细胞静脉注射(每只大鼠 10 6 个细胞)一次。实验结束后将大鼠处死,抽血化验血清尿素和肌酐。制备肾脏样本用于光镜和电子显微镜检查。结果糖尿病组大鼠表现出生化和组织学改变,即滤过空间扩张、局灶性裂解(变性)区域和毛细血管充血。胰岛素组肾小管毁损,细胞质空泡化,而间叶干细胞组肾小管外观正常,鲍曼间隙轻度增大,对肾功能有显著改善作用。结论胰岛素和间充质干细胞治疗可改善糖尿病大鼠肾脏的组织学和生化指标。
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引用次数: 0
The Value of Knife Add-on to Vessel Sealing Devices: A Retrospective Comparison of Covidien Ligasure Impact and ERBE Biclamp 200 in Non-descent Vaginal Hysterectomy 血管封堵装置的附加刀的价值:Covidien Ligasure Impact 和 ERBE Biclamp 200 在非后天性阴道子宫切除术中的回顾性比较
Pub Date : 2024-03-03 DOI: 10.21608/bmfj.2024.239516.1910
Ahmed Kasem Mohamed Zain Eldin, Ashraf Elmantwe, Hossam Elbanhawy, Mohamed El noury, Ahmed Sabra
: Background: non-descent vaginal hysterectomy (NDVH)is the differentiating procedure of gynecologic surgeons, introducing a new technique is crucial. Aim: To contrast perioperative consequences of employing Covidien LigaSure Impact™ with built-in add-on knife (Curved Large Jaw Open Sealer / Divider) and ERBE BiClamp®200C (Curved Sealer) standalone forceps with use of separate scissors for executing NDVH. Patients and methods: A retrospective analysis included 164 NDVH executed between January 2015 and April 2023 in Benha University Hospital. The LigaSure Impact™ group included 86 NDVH. The BiClamp® group included 78 NDVH. Results: Both groups showed no significant dissimilarity regarding their age, BMI, parity, preoperative mean hemoglobin levels, associated comorbidities, numbers of prior Cesarean section (CS), the indications for hysterectomy, the preoperative HBA1c or the preoperative hospital administration(P>0.05). Also, there was no difference between both groups in operative time, blood loss, removed uterine weight, intra-operative complications, need for blood transfusion, rates of incidental cystotomy, need for additional general anesthesia intraoperatively, shorter postoperative hospital stay, wound complications, less consumption of analgesic and lower amount as well as the need for postoperative venous thromboembolic prophylaxis (VTE), earlier ambulation, earlier return to daily activity, earlier resumption of coital activity, need to reoperate for wound-related complication (P>0.05). Conclusion: NDVH could be safely and efficiently achieved either Covidien LigaSure Impact™ or by ERBE BiClamp®200C. The gynecologist should follow the recommendations of gynecologic societies at least for feasible mobile non-scared uteri with uterine size up to 12 weeks needed to be extirpated to be accomplished vaginally.
:背景:非后天性阴道子宫切除术(NDVH)是妇科外科医生的特色手术,引进新技术至关重要。目的:对比使用带内置附加刀的 Covidien LigaSure Impact™(弯形大钳开口封堵器/分割器)和 ERBE BiClamp®200C (弯形封堵器)独立镊子与使用单独剪刀实施 NDVH 的围手术期后果。患者和方法:回顾性分析包括 2015 年 1 月至 2023 年 4 月期间在本哈大学医院实施的 164 例 NDVH。LigaSure Impact™ 组包括 86 例 NDVH。BiClamp® 组包括 78 例 NDVH。结果:两组在年龄、体重指数(BMI)、胎次、术前平均血红蛋白水平、相关合并症、既往剖宫产次数(CS)、子宫切除术指征、术前 HBA1c 或术前医院管理方面均无明显差异(P>0.05)。此外,两组在手术时间、失血量、切除子宫重量、术中并发症、输血需求、意外膀胱切开率、术中追加全身麻醉需求、术后住院时间缩短、伤口并发症、镇痛剂用量减少等方面均无差异、伤口并发症、镇痛剂用量减少、术后静脉血栓栓塞预防(VTE)需要量减少、更早下地行走、更早恢复日常活动、更早恢复同房活动、因伤口相关并发症需要再次手术(P>0.05)。05).结论Covidien LigaSure Impact™ 或 ERBE BiClamp®200C 均可安全有效地实现 NDVH。妇科医生应遵循妇科协会的建议,至少在可行的情况下,对子宫大小不超过 12 周的活动性无疤痕子宫进行阴道切除。
{"title":"The Value of Knife Add-on to Vessel Sealing Devices: A Retrospective Comparison of Covidien Ligasure Impact and ERBE Biclamp 200 in Non-descent Vaginal Hysterectomy","authors":"Ahmed Kasem Mohamed Zain Eldin, Ashraf Elmantwe, Hossam Elbanhawy, Mohamed El noury, Ahmed Sabra","doi":"10.21608/bmfj.2024.239516.1910","DOIUrl":"https://doi.org/10.21608/bmfj.2024.239516.1910","url":null,"abstract":": Background: non-descent vaginal hysterectomy (NDVH)is the differentiating procedure of gynecologic surgeons, introducing a new technique is crucial. Aim: To contrast perioperative consequences of employing Covidien LigaSure Impact™ with built-in add-on knife (Curved Large Jaw Open Sealer / Divider) and ERBE BiClamp®200C (Curved Sealer) standalone forceps with use of separate scissors for executing NDVH. Patients and methods: A retrospective analysis included 164 NDVH executed between January 2015 and April 2023 in Benha University Hospital. The LigaSure Impact™ group included 86 NDVH. The BiClamp® group included 78 NDVH. Results: Both groups showed no significant dissimilarity regarding their age, BMI, parity, preoperative mean hemoglobin levels, associated comorbidities, numbers of prior Cesarean section (CS), the indications for hysterectomy, the preoperative HBA1c or the preoperative hospital administration(P>0.05). Also, there was no difference between both groups in operative time, blood loss, removed uterine weight, intra-operative complications, need for blood transfusion, rates of incidental cystotomy, need for additional general anesthesia intraoperatively, shorter postoperative hospital stay, wound complications, less consumption of analgesic and lower amount as well as the need for postoperative venous thromboembolic prophylaxis (VTE), earlier ambulation, earlier return to daily activity, earlier resumption of coital activity, need to reoperate for wound-related complication (P>0.05). Conclusion: NDVH could be safely and efficiently achieved either Covidien LigaSure Impact™ or by ERBE BiClamp®200C. The gynecologist should follow the recommendations of gynecologic societies at least for feasible mobile non-scared uteri with uterine size up to 12 weeks needed to be extirpated to be accomplished vaginally.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140267258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Echocardiographic Abnormalities and Carotid Artery Atherosclerosis in Metabolic Associated Fatty Liver Disease Patients 代谢相关性脂肪肝患者的超声心动图异常和颈动脉粥样硬化
Pub Date : 2024-03-03 DOI: 10.21608/bmfj.2024.256775.1981
Alaa Kandil, Hossam Baiomy, Hatem Samir Abdel-Raouf Elegily, Ehab Kamal El-melegy, Mai Abd Elshafy Elbahlwan, Yousry Esam-Eldin Abo-Amer
: Background: MAFLD is prevalent throughout the world, with an estimated prevalence 25%. Although advanced liver fibrosis has been shown to have a significant impact on the incidence and mortality of cardiovascular diseases (CVDs) in individuals with MAFLD, the relationship between the degree of liver fibrosis and carotid atherosclerosis is still debated. Aim and objectives: to evaluate the echocardiographic abnormalities and carotid artery atherosclerosis in MAFLD patients. Patients and methods: This cross-sectional study was carried out on 49 patients diagnosed with MAFLD at hepatology, gastroenterology outpatient clinic at mahalla hepatology teaching hospital. Results: The mean age ±SD was 43.69 ± 11.36; there were 20.4 % male, 79.6 % female. There was statistically significant correlation between steatosis score and age, AST to platelets ratio, FIB4 score, NAFLD score, systolic blood pressure (SBP), diastolic blood pressure (DBP), fibrosis, triglycerides (TG), total cholesterol, high density lipoprotein (HDL), and low-density lipoprotein (LDL). There was a statistically significant correlation between steatosis score and left Carotid and left ventricular global longitudinal strain (LVGLS). Conclusion: we can conclude that MAFLD has a significant association with higher cardiovascular risk in terms of carotid artery atherosclerosis and echocardiographic abnormalities.
:背景:肝纤维化和脂肪肝在全世界普遍存在,估计发病率为25%。尽管晚期肝纤维化已被证明对 MAFLD 患者心血管疾病(CVDs)的发病率和死亡率有显著影响,但肝纤维化程度与颈动脉粥样硬化之间的关系仍存在争议。目的和目标:评估 MAFLD 患者的超声心动图异常和颈动脉粥样硬化。患者和方法:这项横断面研究的对象是马哈拉肝病教学医院肝病消化科门诊确诊的 49 名 MAFLD 患者。研究结果平均年龄(±SD)为 43.69±11.36 岁;男性占 20.4%,女性占 79.6%。脂肪变性评分与年龄、谷草转氨酶与血小板比率、FIB4评分、非酒精性脂肪肝评分、收缩压(SBP)、舒张压(DBP)、纤维化、甘油三酯(TG)、总胆固醇、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)之间存在统计学意义上的显著相关性。脂肪变性评分与左颈动脉和左心室整体纵向应变(LVGLS)之间存在统计学意义上的显著相关性。结论:我们可以得出结论,从颈动脉粥样硬化和超声心动图异常的角度来看,MAFLD 与较高的心血管风险有明显的关联。
{"title":"Echocardiographic Abnormalities and Carotid Artery Atherosclerosis in Metabolic Associated Fatty Liver Disease Patients","authors":"Alaa Kandil, Hossam Baiomy, Hatem Samir Abdel-Raouf Elegily, Ehab Kamal El-melegy, Mai Abd Elshafy Elbahlwan, Yousry Esam-Eldin Abo-Amer","doi":"10.21608/bmfj.2024.256775.1981","DOIUrl":"https://doi.org/10.21608/bmfj.2024.256775.1981","url":null,"abstract":": Background: MAFLD is prevalent throughout the world, with an estimated prevalence 25%. Although advanced liver fibrosis has been shown to have a significant impact on the incidence and mortality of cardiovascular diseases (CVDs) in individuals with MAFLD, the relationship between the degree of liver fibrosis and carotid atherosclerosis is still debated. Aim and objectives: to evaluate the echocardiographic abnormalities and carotid artery atherosclerosis in MAFLD patients. Patients and methods: This cross-sectional study was carried out on 49 patients diagnosed with MAFLD at hepatology, gastroenterology outpatient clinic at mahalla hepatology teaching hospital. Results: The mean age ±SD was 43.69 ± 11.36; there were 20.4 % male, 79.6 % female. There was statistically significant correlation between steatosis score and age, AST to platelets ratio, FIB4 score, NAFLD score, systolic blood pressure (SBP), diastolic blood pressure (DBP), fibrosis, triglycerides (TG), total cholesterol, high density lipoprotein (HDL), and low-density lipoprotein (LDL). There was a statistically significant correlation between steatosis score and left Carotid and left ventricular global longitudinal strain (LVGLS). Conclusion: we can conclude that MAFLD has a significant association with higher cardiovascular risk in terms of carotid artery atherosclerosis and echocardiographic abnormalities.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"109 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140267113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is an enlarged fibroid uterus a contraindication for Non-Descent Vaginal Hysterectomy (NDVH)? Retrospective comparison between cohort whose uterine size ≥ 12 weeks and cohort whose uterine size less than 12 weeks underwent NDVH. 子宫肌瘤增大是非后天性阴道子宫切除术(NDVH)的禁忌症吗?对子宫大小≥12周和子宫大小小于12周接受非后天性阴道子宫切除术的人群进行回顾性比较。
Pub Date : 2024-03-03 DOI: 10.21608/bmfj.2024.243409.1928
Ahmed Ahmed, Ashraf Elmantwe, Ahmed Helal, Ahmed Sabra, Hossam Elbanhawy, Fatma Darwish
: Background: An enlarged fibroid uterus greater than 12 weeks considered a contraindication for Non-Descent Vaginal Hysterectomy (NDVH) by most gynecologic surgeons, is this contraindication real or alleged? Aim: to evaluate impact of uterine size on peri-operative consequences in women underwent NDVH for benign conditions. Patients and Methods: This study includes 340 women underwent NDVH; 232 women had uterine size up to 12 weeks (control group) and 108 women had uterine size more than 12 and up to 24 weeks (index group). Results: Both groups were similar regards menopausal, nulliparity status, number of prior vaginal birth, preoperative medical status, and American Society of Anesthesiologists grades (P>0.05), but different in percentage of women with fibroids, cervical pathology, prior Cesarean section, and virgin lower abdomen(P<0.05). No important differences were detected in perioperative outcomes as transfusion, thrombosis, ureteral, bladder, or bowel injuries, fever, systemic infections, fistula, conversion to total abdominal hysterectomy, total postoperative (PO) complications and length of PO hospital stay (P>0.05). However, the effect of uterine size larger than 12 weeks in comparison to uterine size up to 12 weeks was significant on the subsequent outcomes total operative time (55 minutes) operative blood loss (160 ml), needs for general anesthesia, needs for debulking, needs for analgesics, decline in PO HB, and return to usual activity(P<0.05). Conclusion: Non-Descent Vaginal Hysterectomy (NDVH) cloud be executed for women had fibroids with uterine size greater than 12 weeks without increase in perioperative morbid outcomes when compared to women with uterine size up to 12 weeks.
:背景:大多数妇科外科医生认为大于 12 周的增大子宫肌瘤是非后天性阴道子宫切除术(NDVH)的禁忌症。目的:评估子宫大小对因良性疾病接受 NDVH 的妇女围手术期后果的影响。患者和方法:本研究包括 340 名接受 NDVH 的女性,其中 232 名女性的子宫大小在 12 周以内(对照组),108 名女性的子宫大小在 12 周以上至 24 周以内(指标组)。结果两组在绝经期、无排卵状态、既往阴道分娩次数、术前医疗状况和美国麻醉医师协会等级方面相似(P>0.05),但在子宫肌瘤、宫颈病变、既往剖宫产和处女下腹部比例方面不同(P0.05)。然而,子宫大小大于 12 周与子宫大小小于 12 周相比,对后续结果的影响是显著的,包括总手术时间(55 分钟)、手术失血量(160 毫升)、全身麻醉需求、清宫需求、镇痛药需求、PO HB 下降和恢复正常活动(P<0.05)。结论与子宫大小不超过12周的妇女相比,子宫大小超过12周的子宫肌瘤妇女可以实施非后天性阴道子宫切除术(NDVH),而不会增加围手术期的不良后果。
{"title":"Is an enlarged fibroid uterus a contraindication for Non-Descent Vaginal Hysterectomy (NDVH)? Retrospective comparison between cohort whose uterine size ≥ 12 weeks and cohort whose uterine size less than 12 weeks underwent NDVH.","authors":"Ahmed Ahmed, Ashraf Elmantwe, Ahmed Helal, Ahmed Sabra, Hossam Elbanhawy, Fatma Darwish","doi":"10.21608/bmfj.2024.243409.1928","DOIUrl":"https://doi.org/10.21608/bmfj.2024.243409.1928","url":null,"abstract":": Background: An enlarged fibroid uterus greater than 12 weeks considered a contraindication for Non-Descent Vaginal Hysterectomy (NDVH) by most gynecologic surgeons, is this contraindication real or alleged? Aim: to evaluate impact of uterine size on peri-operative consequences in women underwent NDVH for benign conditions. Patients and Methods: This study includes 340 women underwent NDVH; 232 women had uterine size up to 12 weeks (control group) and 108 women had uterine size more than 12 and up to 24 weeks (index group). Results: Both groups were similar regards menopausal, nulliparity status, number of prior vaginal birth, preoperative medical status, and American Society of Anesthesiologists grades (P>0.05), but different in percentage of women with fibroids, cervical pathology, prior Cesarean section, and virgin lower abdomen(P<0.05). No important differences were detected in perioperative outcomes as transfusion, thrombosis, ureteral, bladder, or bowel injuries, fever, systemic infections, fistula, conversion to total abdominal hysterectomy, total postoperative (PO) complications and length of PO hospital stay (P>0.05). However, the effect of uterine size larger than 12 weeks in comparison to uterine size up to 12 weeks was significant on the subsequent outcomes total operative time (55 minutes) operative blood loss (160 ml), needs for general anesthesia, needs for debulking, needs for analgesics, decline in PO HB, and return to usual activity(P<0.05). Conclusion: Non-Descent Vaginal Hysterectomy (NDVH) cloud be executed for women had fibroids with uterine size greater than 12 weeks without increase in perioperative morbid outcomes when compared to women with uterine size up to 12 weeks.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"76 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140267212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Vaginal Progesterone after tocolytic therapy in threatened preterm labor. 溶催产素治疗后阴道黄体酮对早产威胁的影响。
Pub Date : 2024-02-24 DOI: 10.21608/bmfj.2024.258940.1986
Ahmed K.Abbas, Wael Naeem, omar k.Naser, Ahmed Gamal Goda Helal, Labiba Kasem Elsayed, Heba Khatab, Ali A. Bendary
: Background: Preterm labor, accounts for the vast majority of infant mortality and morbidity. One of perinatal care primary goals is now the prevention of preterm labor. Aim: to determine whether vaginal progesterone maintenance medication could lengthen the latency period following a successful episode of preterm labor, this study examined this possibility. Methods: The women were split into two groups when the uterine contractions stopped: 50 patients made up the first group (the study group). A micronized vaginal progesterone supplement was administered to women daily in doses of 200 mg. Progesterone vaginal suppository was continued, and the women were told to reduce their physical activity, until 36 weeks of gestation. There were 50 patients in the second group (the control group). In addition to being told to minimize their physical activity, women were not offered any medicines or follow-up care. Patients were kept in the hospital if labor pain persisted; otherwise, if they were stable, they were released . Results: the study discovered that vaginal progesterone lower the risk of labor before 37 weeks of gestation for women who are more likely to high risk for preterm labor. Accordingly, treatment with progesterone agents to lessen preterm birth complications should continue to women who are at risk. Conclusion: In this study, it was discovered that preventive treatment of 200 mg vaginal suppositories of progesterone following successful tocolysis was linked to a longer gestation period and improved fetal outcomes in high-risk patients.
:背景:早产是婴儿死亡和发病的主要原因。目前,围产期保健的主要目标之一就是预防早产。目的:为了确定阴道黄体酮维持药物是否能延长早产成功后的潜伏期,本研究探讨了这种可能性。研究方法当子宫收缩停止时,产妇被分成两组:50 名患者组成第一组(研究组)。每天给妇女服用微粉化的阴道黄体酮补充剂,剂量为 200 毫克。继续使用黄体酮阴道栓剂,并告知妇女减少体力活动,直至妊娠 36 周。第二组(对照组)有 50 名患者。除了被告知尽量减少体力活动外,妇女们没有获得任何药物或后续护理。如果分娩疼痛持续存在,患者将被留在医院;否则,如果情况稳定,她们就可以出院。结果:研究发现,对于早产风险较高的妇女来说,阴道黄体酮可降低妊娠 37 周前分娩的风险。因此,应继续对高危产妇使用黄体酮药物治疗,以减少早产并发症。结论这项研究发现,在成功溶宫后使用 200 毫克黄体酮阴道栓剂进行预防性治疗,可延长高风险患者的妊娠期并改善胎儿预后。
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Benha Medical Journal
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