Pub Date : 2024-02-24DOI: 10.21608/bmfj.2024.265553.2004
Soheir Abdelsamea, Rana Khashaba, A. Amer, Omnia Abd Allah Ahmed khalifa, S. Ameen
: Background: Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory illness. Proinflammatory cytokines play a crucial role in the development of RA by inducing an inflammatory response. One of these cytokines is interleukin-21 (IL-21), which regulates B-cell proliferation, plasma differentiation, and immunoglobulin synthesis; consequently, IL-21's actions on B cells may take part in the development of autoimmune disorders. Aim of the study: to investigate the association between plasma IL-21 gene polymorphism and susceptibility to RA in Egyptian patients and to find out its relation to disease activity. Methods: The case-control study was performed on 100 subjects; divided into two groups: Group(I):70 RA patients, Group (II):30 healthy matched controls. Through history taking, clinical examination and assessment of IL-21 gene rs2055979 by quantitative Real-Time PCR (qRT-PCR). Evaluation of disease activity by using the Disease Activity Score (DAS-28 score). Results: RA patients were significantly associated with a higher frequency of rs2055979 AA genotype and A allele (p= 0.023, 0.028) with risk to RA development (OR=2.759, 2.040 respectively). IL-21 genotypes AA and CA were significantly associated with higher DAS-28 when compared to the CC genotype (p≤0.05). On regression analysis, IL21 dominant models were considered independent risk predictors of higher RA disease activity (<0.001). Conclusion: In the Egyptian population, IL-21 gene variants are linked to RA susceptibility. The SNP rs2055979 AA genotype was associated with Egyptian RA patients.
:背景：类风湿性关节炎（RA）是一种慢性自身免疫性炎症疾病。促炎细胞因子通过诱导炎症反应，在类风湿性关节炎的发病过程中起着至关重要的作用。这些细胞因子之一是白细胞介素-21（IL-21），它能调节 B 细胞的增殖、血浆分化和免疫球蛋白的合成；因此，IL-21 对 B 细胞的作用可能参与自身免疫性疾病的发展。研究目的：调查埃及患者血浆中IL-21基因多态性与RA易感性之间的关系，并找出其与疾病活动的关系。研究方法对 100 名受试者进行病例对照研究，分为两组：组（I）：70 名 RA 患者；组（II）：30 名健康匹配对照组。通过病史采集、临床检查和实时定量 PCR（qRT-PCR）评估 IL-21 基因 rs2055979。使用疾病活动性评分（DAS-28 评分）评估疾病活动性。结果显示RA患者的rs2055979 AA基因型和A等位基因频率较高（p= 0.023和0.028），与RA发病风险明显相关（OR=2.759和2.040）。与 CC 基因型相比，IL-21 基因型 AA 和 CA 与较高的 DAS-28 显著相关（p≤0.05）。在回归分析中，IL21显性模型被认为是较高RA疾病活动性的独立风险预测因子（<0.001）。结论在埃及人群中，IL-21 基因变异与 RA 易感性有关。SNP rs2055979 AA 基因型与埃及 RA 患者有关。
{"title":"A study of the association between plasma interleukin-21 gene polymorphism and the susceptibility to rheumatoid arthritis in Egyptian patients","authors":"Soheir Abdelsamea, Rana Khashaba, A. Amer, Omnia Abd Allah Ahmed khalifa, S. Ameen","doi":"10.21608/bmfj.2024.265553.2004","DOIUrl":"https://doi.org/10.21608/bmfj.2024.265553.2004","url":null,"abstract":": Background: Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory illness. Proinflammatory cytokines play a crucial role in the development of RA by inducing an inflammatory response. One of these cytokines is interleukin-21 (IL-21), which regulates B-cell proliferation, plasma differentiation, and immunoglobulin synthesis; consequently, IL-21's actions on B cells may take part in the development of autoimmune disorders. Aim of the study: to investigate the association between plasma IL-21 gene polymorphism and susceptibility to RA in Egyptian patients and to find out its relation to disease activity. Methods: The case-control study was performed on 100 subjects; divided into two groups: Group(I):70 RA patients, Group (II):30 healthy matched controls. Through history taking, clinical examination and assessment of IL-21 gene rs2055979 by quantitative Real-Time PCR (qRT-PCR). Evaluation of disease activity by using the Disease Activity Score (DAS-28 score). Results: RA patients were significantly associated with a higher frequency of rs2055979 AA genotype and A allele (p= 0.023, 0.028) with risk to RA development (OR=2.759, 2.040 respectively). IL-21 genotypes AA and CA were significantly associated with higher DAS-28 when compared to the CC genotype (p≤0.05). On regression analysis, IL21 dominant models were considered independent risk predictors of higher RA disease activity (<0.001). Conclusion: In the Egyptian population, IL-21 gene variants are linked to RA susceptibility. The SNP rs2055979 AA genotype was associated with Egyptian RA patients.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140434841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-17DOI: 10.21608/bmfj.2024.246791.1962
A. Ebeed, M. Refaat, May Mohamed Elsafty, Osama Galal
: Background: A member of pattern recognition receptors is the toll-like Metastatic hepatic focal lesions in breast cancer patients undergoing chemotherapy present diagnostic challenges. This study aimed to detect hepatic focal lesion in patients with cancer breast under chemotherapy. Methods: This observational cross-sectional study was conducted in the Radiology department of Tanta Cancer Center and included 50 adult female patients with primary breast cancer undergoing chemotherapy. Patients were subjected to a full history taking, clinical oncological examination, routine laboratory investigation, and multi-slice triphasic CT scans. Computed tomography images were analyzed for the location, number, size, shape, borders, and enhancement pattern of hepatic focal lesions. Histopathological examination results were used as the reference standard for the diagnosis of metastasis. Results: A total of 95 hepatic focal lesions were detected, with the majority in segment VIII (29.47%). Lesions displayed different enhancement patterns, with the most common being a complete ring (47.36%). Triphasic CT demonstrated a significant advantage in the prediction of liver metastasis compared to MRI, with a high positive predictive value (94.59) compared to MRI (97.36). The sensitivity and specificity of CT and MRI for diagnosing liver metastasis were 90% and 94.87% for CT, and 72% and 75% for MRI, respectively. Triphasic CT showed a high positive predictive value (94.59) compared to MRI (97.36). Conclusion: Multi-slice triphasic CT is a valuable diagnostic tool for the assessment of hepatic focal lesions in breast cancer patients undergoing chemotherapy.
{"title":"Role of Multislice Triphasic C.T in Assessment of Metastatic Hepatic Focal Lesion in Cancer Breast under Chemotherapy","authors":"A. Ebeed, M. Refaat, May Mohamed Elsafty, Osama Galal","doi":"10.21608/bmfj.2024.246791.1962","DOIUrl":"https://doi.org/10.21608/bmfj.2024.246791.1962","url":null,"abstract":": Background: A member of pattern recognition receptors is the toll-like Metastatic hepatic focal lesions in breast cancer patients undergoing chemotherapy present diagnostic challenges. This study aimed to detect hepatic focal lesion in patients with cancer breast under chemotherapy. Methods: This observational cross-sectional study was conducted in the Radiology department of Tanta Cancer Center and included 50 adult female patients with primary breast cancer undergoing chemotherapy. Patients were subjected to a full history taking, clinical oncological examination, routine laboratory investigation, and multi-slice triphasic CT scans. Computed tomography images were analyzed for the location, number, size, shape, borders, and enhancement pattern of hepatic focal lesions. Histopathological examination results were used as the reference standard for the diagnosis of metastasis. Results: A total of 95 hepatic focal lesions were detected, with the majority in segment VIII (29.47%). Lesions displayed different enhancement patterns, with the most common being a complete ring (47.36%). Triphasic CT demonstrated a significant advantage in the prediction of liver metastasis compared to MRI, with a high positive predictive value (94.59) compared to MRI (97.36). The sensitivity and specificity of CT and MRI for diagnosing liver metastasis were 90% and 94.87% for CT, and 72% and 75% for MRI, respectively. Triphasic CT showed a high positive predictive value (94.59) compared to MRI (97.36). Conclusion: Multi-slice triphasic CT is a valuable diagnostic tool for the assessment of hepatic focal lesions in breast cancer patients undergoing chemotherapy.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"57 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-17DOI: 10.21608/bmfj.2024.247532.1948
A. El-Taweel, Amany Mustafa, Mohamed M. Fouda, Essam El-Sawy,, Rasha Saad
: Background: Uremic pruritus is a common symptom in patients with end-stage renal disease who are undergoing maintenance hemodialysis. This symptom is frequently refractory to most treatments, and is associated with substantial medical, psychological, and social disturbances in patients receiving dialysis. This study aimed to estimate serum level of IL31, in patients with uremic pruritus and to relate it with different clinical parameters. Methods: This was a prospective case-control study conducted on participants recruited from the hemodialysis unit of the Urology and Nephrology Center, Mansoura University. Results: serum IL-31 is significantly higher in patients receiving hemodialysis with pruritus symptoms, along with a positive exposure-response relationship between serum IL-31 and pruritus intensity. Conclusion: Uremic pruritus, is a distressing symptom in end-stage renal disease patients on hemodialysis, which lacks a definitive explanation, though factors like immune processes and IL-31 are considered. Its impact on patients' quality of life varies, making it challenging to characterize. Unraveling mechanisms like IL-31 may guide future treatments for this condition, which significantly affects patients' well-being.
{"title":"Serum Level of Interleukin-31 in Patients with Uremic Pruritus Undergoing Hemodialysis","authors":"A. El-Taweel, Amany Mustafa, Mohamed M. Fouda, Essam El-Sawy,, Rasha Saad","doi":"10.21608/bmfj.2024.247532.1948","DOIUrl":"https://doi.org/10.21608/bmfj.2024.247532.1948","url":null,"abstract":": Background: Uremic pruritus is a common symptom in patients with end-stage renal disease who are undergoing maintenance hemodialysis. This symptom is frequently refractory to most treatments, and is associated with substantial medical, psychological, and social disturbances in patients receiving dialysis. This study aimed to estimate serum level of IL31, in patients with uremic pruritus and to relate it with different clinical parameters. Methods: This was a prospective case-control study conducted on participants recruited from the hemodialysis unit of the Urology and Nephrology Center, Mansoura University. Results: serum IL-31 is significantly higher in patients receiving hemodialysis with pruritus symptoms, along with a positive exposure-response relationship between serum IL-31 and pruritus intensity. Conclusion: Uremic pruritus, is a distressing symptom in end-stage renal disease patients on hemodialysis, which lacks a definitive explanation, though factors like immune processes and IL-31 are considered. Its impact on patients' quality of life varies, making it challenging to characterize. Unraveling mechanisms like IL-31 may guide future treatments for this condition, which significantly affects patients' well-being.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-17DOI: 10.21608/bmfj.2024.258349.1985
Nour Ibrahim, Tamer Assar, A. Negm, Mayada Adel, Ahmed Mohamed
: Background: Nabothian cysts are common benign cervical lesions often discovered incidentally during routine gynecological examinations. While they are typically asymptomatic, they may occasionally present with various clinical complaints. This study aimed to correlate between cytological or bacteriological findings and presence of nabothian cysts. Methods: This prospective observational study was carried out on one hundred women with confirmed cervical Nabothian cysts. The study was conducted at the Obstetrics and Gynecology Department of Benha University Hospitals between April 2022 and December 2022. Detailed clinical evaluations, including history taking, transvaginal ultrasound examination, cytological diagnosis using the Papanicolaou method, and bacteriological examination of cervical swabs and cyst aspirates, were performed. Results were analyzed to assess the characteristics of Nabothian cysts, cytological findings, and microbiological assessments. Results: Of the 100 participants, 60% were in the 31-40 age range, with 37% having two children. Complaints included 63% reporting discharge, 51% experiencing pelvic pain, and 8% facing infertility issues. Most cysts (68%) were larger than 10mm and located in the upper part of the cervix (57%). Cytological results revealed 8% with intraepithelial lesions and 3% with malignancy. Bacteriological assessments showed 40% had bacterial growth, with 28% displaying gram-negative bacilli. The presence of bacterial growth correlated with inflammatory changes and malignancy. Conclusion: Cytological and bacteriological assessments of Nabothian cysts in women with related complaints can provide valuable insights into their etiology and associated conditions. The presence of bacterial growth and specific bacterial strains may be linked to inflammatory changes and malignancy in these cysts.
{"title":"Cytological and Bacteriological Assessment of the Cervix in Cases Having Nabothian Cysts","authors":"Nour Ibrahim, Tamer Assar, A. Negm, Mayada Adel, Ahmed Mohamed","doi":"10.21608/bmfj.2024.258349.1985","DOIUrl":"https://doi.org/10.21608/bmfj.2024.258349.1985","url":null,"abstract":": Background: Nabothian cysts are common benign cervical lesions often discovered incidentally during routine gynecological examinations. While they are typically asymptomatic, they may occasionally present with various clinical complaints. This study aimed to correlate between cytological or bacteriological findings and presence of nabothian cysts. Methods: This prospective observational study was carried out on one hundred women with confirmed cervical Nabothian cysts. The study was conducted at the Obstetrics and Gynecology Department of Benha University Hospitals between April 2022 and December 2022. Detailed clinical evaluations, including history taking, transvaginal ultrasound examination, cytological diagnosis using the Papanicolaou method, and bacteriological examination of cervical swabs and cyst aspirates, were performed. Results were analyzed to assess the characteristics of Nabothian cysts, cytological findings, and microbiological assessments. Results: Of the 100 participants, 60% were in the 31-40 age range, with 37% having two children. Complaints included 63% reporting discharge, 51% experiencing pelvic pain, and 8% facing infertility issues. Most cysts (68%) were larger than 10mm and located in the upper part of the cervix (57%). Cytological results revealed 8% with intraepithelial lesions and 3% with malignancy. Bacteriological assessments showed 40% had bacterial growth, with 28% displaying gram-negative bacilli. The presence of bacterial growth correlated with inflammatory changes and malignancy. Conclusion: Cytological and bacteriological assessments of Nabothian cysts in women with related complaints can provide valuable insights into their etiology and associated conditions. The presence of bacterial growth and specific bacterial strains may be linked to inflammatory changes and malignancy in these cysts.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"391 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-17DOI: 10.21608/bmfj.2024.252023.1963
Hossam Mohammed Abd ElAzim, Huda Ahmed Salman, Hamada Hashem
: Background: The CoVID-19 pandemic necessitated the rapid development and deployment of multiple vaccines globally, including Egypt. Understanding the side effects associated with these vaccines is crucial for informed decision-making and public health policy. This study aimed to compare the side effects of the different type of corona vaccines in the Arab Republic of Egypt. Methods: This retrospective comparative study was carried out on a sample of 1050 individuals who had received CoVID-19 vaccines between 2021 and 2022 in Egypt. Informed written consent was obtained from all participants, and ethical approval was granted by the Research Ethics Committee, Faculty of Medicine, Benha University. Participants were categorized into groups based on the vaccine received. Side effects were documented, and CoVID -19 anti-spike antibodies were measured 21 days and 6 months post-vaccination. Results: Significant differences were observed in symptoms such as cough, pharyngitis, nasal congestion, runny nose, epistaxis, anosmia, dizziness, and drowsiness. However, there were no significant differences in antibody levels among the vaccine types at 6 months post-vaccination. Conclusion: In Egypt, the most frequent CoVID-19 vaccine side effects were headache, fever, fatigue, muscle pain, and joint pain. AstraZeneca and Moderna vaccines had higher rates of these side effects. AstraZeneca also exhibited more common side effects such as cough, pharyngitis, nasal congestion, epistaxis, anosmia, dizziness, drowsiness, appetite loss, nausea, vomiting, abdominal pain, diarrhea, and constipation. Allergic reactions, including skin rash, eyelid swelling, and eye redness, were more prevalent with the AstraZeneca vaccine.
{"title":"Covid Vaccine in Egypt \" What To expect before you get ?\"","authors":"Hossam Mohammed Abd ElAzim, Huda Ahmed Salman, Hamada Hashem","doi":"10.21608/bmfj.2024.252023.1963","DOIUrl":"https://doi.org/10.21608/bmfj.2024.252023.1963","url":null,"abstract":": Background: The CoVID-19 pandemic necessitated the rapid development and deployment of multiple vaccines globally, including Egypt. Understanding the side effects associated with these vaccines is crucial for informed decision-making and public health policy. This study aimed to compare the side effects of the different type of corona vaccines in the Arab Republic of Egypt. Methods: This retrospective comparative study was carried out on a sample of 1050 individuals who had received CoVID-19 vaccines between 2021 and 2022 in Egypt. Informed written consent was obtained from all participants, and ethical approval was granted by the Research Ethics Committee, Faculty of Medicine, Benha University. Participants were categorized into groups based on the vaccine received. Side effects were documented, and CoVID -19 anti-spike antibodies were measured 21 days and 6 months post-vaccination. Results: Significant differences were observed in symptoms such as cough, pharyngitis, nasal congestion, runny nose, epistaxis, anosmia, dizziness, and drowsiness. However, there were no significant differences in antibody levels among the vaccine types at 6 months post-vaccination. Conclusion: In Egypt, the most frequent CoVID-19 vaccine side effects were headache, fever, fatigue, muscle pain, and joint pain. AstraZeneca and Moderna vaccines had higher rates of these side effects. AstraZeneca also exhibited more common side effects such as cough, pharyngitis, nasal congestion, epistaxis, anosmia, dizziness, drowsiness, appetite loss, nausea, vomiting, abdominal pain, diarrhea, and constipation. Allergic reactions, including skin rash, eyelid swelling, and eye redness, were more prevalent with the AstraZeneca vaccine.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"518 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.21608/bmfj.2024.216982.1839
Enas Mahdy, Ahmed Abd El-Hamid, Esraa Mohamed Abdalla, Asmaa Mohammed Ebaed
Background: Prolonged ventilatory support is associated with poor clinical outcomes. Pressure support ventilation modes, are frequently used in clinical practice but are associated with patient–ventilator asynchrony and deliver fixed levels of assist. Neurally adjusted ventilatory assist (NAVA), a mode of partial ventilatory assist that reduces patient–ventilator asynchrony compared with other partial support modes for patients with difficult weaning. Objectives: To conduct a meta-analysis comparing neurally adjusted ventilatory assist (NAVA) with pressure support ventilation (PSV), in adult ventilated patients & clinical outcomes. Study design: Meta-analysis was used to address this concern. Sittings: Meta-analysis-based study following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Methods: Online databases (PubMed, Embase, BioMed, and the Cochrane Central Register of Controlled trials)- were used for randomized studies ever performed in humans with NAVA & PSV in any clinical setting. Results: Twelve studies (n = 799 patients) were included. Regarding the primary outcome, patients weaned with NAVA had a higher success rate compared with pressure support ventilation. For the secondary outcomes, NAVA may reduce duration of mechanical ventilation and hospital mortality and prolongs ventilator-free days when compared with other modes. Conclusion: Our study suggests that the (NAVA) mode may improve the rate of weaning success compared with pressure support ventilation for difficult weaning
背景：长时间的通气支持与不良的临床结果有关。压力支持通气模式在临床实践中经常使用，但与患者-呼吸机不同步有关，而且提供的辅助水平固定。神经调节通气辅助（NAVA）是一种部分通气辅助模式，与其他部分通气辅助模式相比，可减少患者与呼吸机的不同步，适用于难以断奶的患者。研究目的对成人通气患者进行荟萃分析，比较神经调节通气辅助（NAVA）与压力支持通气（PSV）的临床效果。研究设计：采用荟萃分析法解决这一问题。坐位基于 Meta 分析的研究，遵循 PRISMA（系统综述和 Meta 分析首选报告项目）指南。方法：在线数据库（PubMed使用在线数据库（PubMed、Embase、BioMed 和 Cochrane Central Register of Controlled trials）--检索在任何临床环境下对人类进行的 NAVA 和 PSV 随机研究。结果：共纳入 12 项研究（n = 799 例患者）。在主要结果方面，与压力支持通气相比，使用 NAVA 断流的患者成功率更高。在次要结果方面，与其他模式相比，NAVA 可缩短机械通气时间，降低住院死亡率，延长无呼吸机天数。结论我们的研究表明，与压力支持通气相比，（NAVA）模式可提高困难断奶患者的断奶成功率。
{"title":"Neurally Adjusted Ventilatory Assist versus Pressure Support Ventilation during weaning A meta-analysis of randomized trials","authors":"Enas Mahdy, Ahmed Abd El-Hamid, Esraa Mohamed Abdalla, Asmaa Mohammed Ebaed","doi":"10.21608/bmfj.2024.216982.1839","DOIUrl":"https://doi.org/10.21608/bmfj.2024.216982.1839","url":null,"abstract":"Background: Prolonged ventilatory support is associated with poor clinical outcomes. Pressure support ventilation modes, are frequently used in clinical practice but are associated with patient–ventilator asynchrony and deliver fixed levels of assist. Neurally adjusted ventilatory assist (NAVA), a mode of partial ventilatory assist that reduces patient–ventilator asynchrony compared with other partial support modes for patients with difficult weaning. Objectives: To conduct a meta-analysis comparing neurally adjusted ventilatory assist (NAVA) with pressure support ventilation (PSV), in adult ventilated patients & clinical outcomes. Study design: Meta-analysis was used to address this concern. Sittings: Meta-analysis-based study following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Methods: Online databases (PubMed, Embase, BioMed, and the Cochrane Central Register of Controlled trials)- were used for randomized studies ever performed in humans with NAVA & PSV in any clinical setting. Results: Twelve studies (n = 799 patients) were included. Regarding the primary outcome, patients weaned with NAVA had a higher success rate compared with pressure support ventilation. For the secondary outcomes, NAVA may reduce duration of mechanical ventilation and hospital mortality and prolongs ventilator-free days when compared with other modes. Conclusion: Our study suggests that the (NAVA) mode may improve the rate of weaning success compared with pressure support ventilation for difficult weaning","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"65 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.21608/bmfj.2024.232007.1883
Osama Elfiqy, Ahmad Sobeih, Hadeel Abdelmonem Mosalam
Background: Food Allergy (FA) is an issue of public health concern since it triggers life-threatening reactions. FA is an adverse immune reaction to a food allergen, mainly of protein nature. Aim: to assess the prevalence of food allergy with the coexistence and severity of asthma rhinitis and eczema in Damnhour city. S ubjects and Methods : Schoolchildren aged 6– 15 years (n 2140) were enrolled in a cross-sectional study. Parents and children completed questionnaires regarding their children's early life exposures and clinical history of FA and allergic diseases. Associations were assessed using Poisson regression with robust variance estimation, and adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated. Results : The 12-month prevalence of study-defined FA was estimated to be 7.1% (150/2140), The mean age of the studied cases was 10.47±2.42 years, there was female predominance about 51.5%, fruits in 16.7%, cow’s milk in 13.3%, egg in 11.3%, chocolate in 10.7%, were the most reported offending food allergens. Eosinophilia was 2.57±1.2, the mean total IgE was129.21±47.5. The prevalence of eczema only was higher in children with study defined FA than in those without study-defined FA. In contrast, this association was not pronounced for children who had asthma only or rhinitis only. Moreover, study-defined FA was associated with increased severity of symptoms of asthma, rhinitis, and eczema.
背景：食物过敏（FA）会引发危及生命的反应，因此是一个备受公众健康关注的问题。食物过敏是一种对食物过敏原（主要是蛋白质）的不良免疫反应。目的：评估 Damnhour 市食物过敏与哮喘鼻炎和湿疹的共存情况和严重程度。研究对象和方法：6-15 岁的学龄儿童（2140 人）参加了横断面研究。家长和儿童填写了有关其子女早期生活接触、FA 和过敏性疾病临床病史的调查问卷。采用泊松回归和稳健方差估计法评估了相关性，并估算了调整患病率比（aPRs）和95%置信区间（CIs）。研究病例的平均年龄为（10.47±2.42）岁，女性占51.5%，报告最多的食物过敏原是水果（16.7%）、牛奶（13.3%）、鸡蛋（11.3%）和巧克力（10.7%）。嗜酸性粒细胞增多率为 2.57±1.2，总 IgE 平均值为 129.21±47.5。仅湿疹的发病率在研究界定的 FA 儿童中就高于未研究界定的 FA 儿童。相比之下，仅患有哮喘或鼻炎的儿童与湿疹的相关性并不明显。此外，研究界定的 FA 与哮喘、鼻炎和湿疹症状的严重程度增加有关。
{"title":"Prevalence of food allergy among schoolchildren and its association with the coexistence and severity of asthma , rhinitis ,and eczema in damanhour city","authors":"Osama Elfiqy, Ahmad Sobeih, Hadeel Abdelmonem Mosalam","doi":"10.21608/bmfj.2024.232007.1883","DOIUrl":"https://doi.org/10.21608/bmfj.2024.232007.1883","url":null,"abstract":"Background: Food Allergy (FA) is an issue of public health concern since it triggers life-threatening reactions. FA is an adverse immune reaction to a food allergen, mainly of protein nature. Aim: to assess the prevalence of food allergy with the coexistence and severity of asthma rhinitis and eczema in Damnhour city. S ubjects and Methods : Schoolchildren aged 6– 15 years (n 2140) were enrolled in a cross-sectional study. Parents and children completed questionnaires regarding their children's early life exposures and clinical history of FA and allergic diseases. Associations were assessed using Poisson regression with robust variance estimation, and adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated. Results : The 12-month prevalence of study-defined FA was estimated to be 7.1% (150/2140), The mean age of the studied cases was 10.47±2.42 years, there was female predominance about 51.5%, fruits in 16.7%, cow’s milk in 13.3%, egg in 11.3%, chocolate in 10.7%, were the most reported offending food allergens. Eosinophilia was 2.57±1.2, the mean total IgE was129.21±47.5. The prevalence of eczema only was higher in children with study defined FA than in those without study-defined FA. In contrast, this association was not pronounced for children who had asthma only or rhinitis only. Moreover, study-defined FA was associated with increased severity of symptoms of asthma, rhinitis, and eczema.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"1131 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.21608/bmfj.2024.259341.1988
Ebada Said, Nadia Abdelkader, Yasser Fouad, Dalia Abd El-Hassib, Amany Mohamed, Ghadeer Rashad
Background and aim: Metabolic dysfunction associated fatty liver disease (MAFLD) affects around one third of the world population. Within the MAFLD population, 19.2% are lean. Low serum vitamin D concentrations were reported to increase the risk of MAFLD. This study aimed to explore the association between serum vitamin D concentration and MAFLD. Methods: This cross-sectional study was conducted on 50 Egyptian patients with lean MAFLD (BMI<25 kg/m2) (GI) and another group (G II) including 50 consecutive overweight/obese patients with MAFLD (BMI <25 kg/m2). MAFLD patients were evaluated by thorough history taking, full clinical examination, laboratory investigations including serum level of 25 hydroxycholecalciferol by ELISA, abdominal ultrasonography and FibroScan ® with controlled attenuation parameter (CAP). Results: Males were significantly predominant in the lean group (G I) (60%) while females were significantly predominant in G II (62%). Mean serum vit D level was not significantly higher in G I compared to GII (16.38 and 15.44 ng/ml, respectively). Vitamin D deficiency (level <20 ng/ml) was predominant in G II (70% vs 58.0% in GI) while insufficiency (level: 20-30 ng/ml) was more common in GI (34% vs 26%). Sufficient vitamin D (level <30 ng/ml) was only found in 8% of GI compared to 4% of GII. Serum vitamin D level showed a highly significant negative correlation with steatosis grades in both groups (r=0.87& 0.88 in GI &GII respectively, P-value <0.001 in both groups) . Conclusion: MAFLD patients, weather lean or obese, show low serum vitamin D levels, which negatively correlate with steatosis grades.
背景和目的：代谢功能障碍相关性脂肪肝（MAFLD）影响着全球约三分之一的人口。在代谢功能障碍相关性脂肪肝患者中，19.2%为瘦弱人群。据报道，血清维生素 D 浓度低会增加患 MAFLD 的风险。本研究旨在探讨血清维生素 D 浓度与 MAFLD 之间的关系。研究方法这项横断面研究的对象是 50 名埃及瘦型 MAFLD 患者（体重指数<25 kg/m2）（GI）和另一组患者（G II），其中包括 50 名连续超重/肥胖的 MAFLD 患者（体重指数<25 kg/m2）。对 MAFLD 患者进行了全面的病史采集、全面的临床检查、实验室检查（包括通过 ELISA 检测血清中 25 羟基胆钙化醇的水平）、腹部超声波检查和带控制衰减参数 (CAP) 的 FibroScan ® 扫描。结果：瘦弱组（G I）中男性明显占多数（60%），而 G II 中女性明显占多数（62%）。G I 的平均血清维生素 D 水平（分别为 16.38 和 15.44 纳克/毫升）并没有明显高于 G II。维生素 D 缺乏症（水平低于 20 纳克/毫升）在 G II 中占主导地位（70% 对 GI 中的 58.0%），而维生素 D 不足症（水平：20-30 纳克/毫升）在 GI 中更为常见（34% 对 26%）。维生素 D 不足（水平：20-30 毫微克/毫升）在 GI 中仅占 8%，而在 GII 中仅占 4%。两组患者的血清维生素 D 水平均与脂肪变性等级呈高度显著的负相关（GI 和 GII 组分别为 r=0.87 和 0.88，两组的 P 值均小于 0.001）。结论MAFLD患者，无论是瘦还是肥，血清维生素D水平都很低，与脂肪变性等级呈负相关。
{"title":"Serum Vitamin D Level in Lean and Obese Patients with Metabolic Associated Fatty Liver Disease: a comparative study","authors":"Ebada Said, Nadia Abdelkader, Yasser Fouad, Dalia Abd El-Hassib, Amany Mohamed, Ghadeer Rashad","doi":"10.21608/bmfj.2024.259341.1988","DOIUrl":"https://doi.org/10.21608/bmfj.2024.259341.1988","url":null,"abstract":"Background and aim: Metabolic dysfunction associated fatty liver disease (MAFLD) affects around one third of the world population. Within the MAFLD population, 19.2% are lean. Low serum vitamin D concentrations were reported to increase the risk of MAFLD. This study aimed to explore the association between serum vitamin D concentration and MAFLD. Methods: This cross-sectional study was conducted on 50 Egyptian patients with lean MAFLD (BMI<25 kg/m2) (GI) and another group (G II) including 50 consecutive overweight/obese patients with MAFLD (BMI <25 kg/m2). MAFLD patients were evaluated by thorough history taking, full clinical examination, laboratory investigations including serum level of 25 hydroxycholecalciferol by ELISA, abdominal ultrasonography and FibroScan ® with controlled attenuation parameter (CAP). Results: Males were significantly predominant in the lean group (G I) (60%) while females were significantly predominant in G II (62%). Mean serum vit D level was not significantly higher in G I compared to GII (16.38 and 15.44 ng/ml, respectively). Vitamin D deficiency (level <20 ng/ml) was predominant in G II (70% vs 58.0% in GI) while insufficiency (level: 20-30 ng/ml) was more common in GI (34% vs 26%). Sufficient vitamin D (level <30 ng/ml) was only found in 8% of GI compared to 4% of GII. Serum vitamin D level showed a highly significant negative correlation with steatosis grades in both groups (r=0.87& 0.88 in GI &GII respectively, P-value <0.001 in both groups) . Conclusion: MAFLD patients, weather lean or obese, show low serum vitamin D levels, which negatively correlate with steatosis grades.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"116 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.21608/bmfj.2024.241994.1918
Shewikar Elbakry, S. Kasem, S. Abd-Elmaksoud, Ayatulla AbdElhameed
: Background: Multiple sclerosis (MS) is the most common demyelinating autoimmune disease affecting the central nervous system (CNS) which can present by various neurological symptoms including visual impairment, numbness and tingling, focal weakness, bladder and bowel incontinence and cognitive dysfunction. Patients with MS rate their health-related quality of life (HRQOL) to be lower than that of the general populations and also lower than patients with other chronic diseases such as epilepsy and diabetes. Patients with multiple sclerosis (MS) frequently report poor sleep, and sleep disorders are more common in MS patients compared to the healthy group. Aim of the work: The aim of the current study was to assess the quality of life and sleep profile in patients with relapsing remitting multiple sclerosis (RRMS). Methods : The study was descriptive comparative case control study which included 40 patients and 40 controls; HRQOL was assessed using the Arabic version of the Multiple Sclerosis Quality of Life-54 questionnaire in RRMS patients. Sleep quality was assessed for both patients and control group using the Arabic version of The Pittsburgh Sleep Quality Index. To measure patients’ degree of disability, the Expanded Disability Status Scale (EDSS) was used. Results: The results showed that RRMS patients have low mean physical and mental composite score. The results also showed that RRMS patients have high global sleep index indicating poor sleep quality. Conclusion: MS patients have limitations as regard physical and cognitive functions in addition to poor sleep quality, which lead to low health related quality of life.
{"title":"Quality of life and sleep profile in relapsing remitting multiple sclerosis patients","authors":"Shewikar Elbakry, S. Kasem, S. Abd-Elmaksoud, Ayatulla AbdElhameed","doi":"10.21608/bmfj.2024.241994.1918","DOIUrl":"https://doi.org/10.21608/bmfj.2024.241994.1918","url":null,"abstract":": Background: Multiple sclerosis (MS) is the most common demyelinating autoimmune disease affecting the central nervous system (CNS) which can present by various neurological symptoms including visual impairment, numbness and tingling, focal weakness, bladder and bowel incontinence and cognitive dysfunction. Patients with MS rate their health-related quality of life (HRQOL) to be lower than that of the general populations and also lower than patients with other chronic diseases such as epilepsy and diabetes. Patients with multiple sclerosis (MS) frequently report poor sleep, and sleep disorders are more common in MS patients compared to the healthy group. Aim of the work: The aim of the current study was to assess the quality of life and sleep profile in patients with relapsing remitting multiple sclerosis (RRMS). Methods : The study was descriptive comparative case control study which included 40 patients and 40 controls; HRQOL was assessed using the Arabic version of the Multiple Sclerosis Quality of Life-54 questionnaire in RRMS patients. Sleep quality was assessed for both patients and control group using the Arabic version of The Pittsburgh Sleep Quality Index. To measure patients’ degree of disability, the Expanded Disability Status Scale (EDSS) was used. Results: The results showed that RRMS patients have low mean physical and mental composite score. The results also showed that RRMS patients have high global sleep index indicating poor sleep quality. Conclusion: MS patients have limitations as regard physical and cognitive functions in addition to poor sleep quality, which lead to low health related quality of life.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"110 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.21608/bmfj.2024.255239.1978
Z. Abdelwahab, Ahmed M. Abdelazeem, Ahmed M. Abdelhameed, Enas Mahdy
This study aimed to assess the ability of lung ultrasound (LUS) to predict mechanical ventilation (MV) weaning outcomes in critically ill adults. Methods: A prospective observational study that analyzed data collected from 50 adult patients, mechanically ventilated for more than 48 hours and eligible for their first spontaneous breathing trial. A LUS was performed prior to and at the end of a 1-hour SBT. To quantify lung aeration, a LUS score was calculated. Patients were divided into two groups according to their response to weaning trials with group A showing successful weaning while group B showing failed weaning. All included patients were followed up to Intensive Care Unit discharge. Results: Weaning failure was observed in 36% of patients. LUS score showed a significant difference between both groups (P < 0.001). Pre-and post-spontaneous breathing trial (post-SBT), LUS scores were significantly higher in the failed weaning group (14.44 ±2.52 and 18.83 ±3.18 respectively) than in the successful weaning group (11.25 ±3.05 and 12.53 ±3.41 respectively). A ROC analysis for the ability of post-SBT LUS score to predict weaning outcomes revealed a significant AUC of 0.911 with a 95% confidence interval ranging from 0.830-0.992 (P < 0.0001). The best cut-off was 14.5, at which sensitivity and specificity were 88.8% and 68.7%, respectively. Conclusions: Our data suggest that LUS can be used as a predictor of MV weaning outcomes in critically ill adults. A post-SBT LUS score cut-off value of 14.5 has a sensitivity and a specificity of 88.8% and 68.7%, respectively.
{"title":"Can Lung Ultrasound Predict Mechanical Ventilation Weaning Outcomes in Critically Ill Adults?","authors":"Z. Abdelwahab, Ahmed M. Abdelazeem, Ahmed M. Abdelhameed, Enas Mahdy","doi":"10.21608/bmfj.2024.255239.1978","DOIUrl":"https://doi.org/10.21608/bmfj.2024.255239.1978","url":null,"abstract":"This study aimed to assess the ability of lung ultrasound (LUS) to predict mechanical ventilation (MV) weaning outcomes in critically ill adults. Methods: A prospective observational study that analyzed data collected from 50 adult patients, mechanically ventilated for more than 48 hours and eligible for their first spontaneous breathing trial. A LUS was performed prior to and at the end of a 1-hour SBT. To quantify lung aeration, a LUS score was calculated. Patients were divided into two groups according to their response to weaning trials with group A showing successful weaning while group B showing failed weaning. All included patients were followed up to Intensive Care Unit discharge. Results: Weaning failure was observed in 36% of patients. LUS score showed a significant difference between both groups (P < 0.001). Pre-and post-spontaneous breathing trial (post-SBT), LUS scores were significantly higher in the failed weaning group (14.44 ±2.52 and 18.83 ±3.18 respectively) than in the successful weaning group (11.25 ±3.05 and 12.53 ±3.41 respectively). A ROC analysis for the ability of post-SBT LUS score to predict weaning outcomes revealed a significant AUC of 0.911 with a 95% confidence interval ranging from 0.830-0.992 (P < 0.0001). The best cut-off was 14.5, at which sensitivity and specificity were 88.8% and 68.7%, respectively. Conclusions: Our data suggest that LUS can be used as a predictor of MV weaning outcomes in critically ill adults. A post-SBT LUS score cut-off value of 14.5 has a sensitivity and a specificity of 88.8% and 68.7%, respectively.","PeriodicalId":503219,"journal":{"name":"Benha Medical Journal","volume":"1084 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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