Sleep disturbances are common among individuals with leukemia, and they can significantly impact their overall well-being. Acupuncture and foot reflexology, two alternative therapies rooted in traditional Chinese medicine, have gained recognition for their potential to address sleep issues and alleviate associated symptoms.
Methods
This single blinded, three-groups randomized controlled trial was navigated at Tohid Hospital, involving 132 leukemia patients divided into acupuncture (n = 44), foot reflexology (n = 44), and control (n = 44) groups via random card selection. All patients completed a demographic questionnaire and the Pittsburgh Sleep Quality Index (PSQI) before the intervention. The acupuncture group received routine care along with twice-daily acupuncture at the SP6 point for four successive weeks. Reflexology group had daily ten-minute sittings for the same weeks using sweet almond oil on their feet. Control group continued by only routine cares. Post-intervention assessments were conducted using the same instruments after four weeks.
Results
The study analyzed patient demographics, finding no significant gender differences and a majority of high school graduates. All groups had similar proportions of singles, high employment rates, and urban residency. Average ages were comparable, with no significant pre-intervention sleep quality differences found. However, both acupuncture and reflexology groups showed significant improvements post-intervention, unlike the control group. While both interventions resulted in lower sleep quality scores compared to the control, no significant difference was observed between the acupuncture and reflexology groups. Trends indicated slight reductions in fatigue for the intervention groups, suggesting both therapies effectively improved sleep quality.
Conclusion
Acupuncture and foot reflexology are suggested as simple and budget-friendly complementary methods that may improve sleep quality for those with leukemia. These therapies provide non-invasive methods to address sleep disturbances and improve overall well-being in leukemia patients.
{"title":"Effects of acupuncture and foot reflexology on sleep quality in patients with acute lymphoblastic leukemia: A clinical trial","authors":"Behnam Babamiri , Raheleh Pourbahram , Mohsen Sayahi , Milad Ahangarzadeh , Rasoul Goli , Navid Faraji , Mohammad Reza Faramarzi","doi":"10.1016/j.explore.2024.103101","DOIUrl":"10.1016/j.explore.2024.103101","url":null,"abstract":"<div><h3>Background</h3><div>Sleep disturbances are common among individuals with leukemia, and they can significantly impact their overall well-being. Acupuncture and foot reflexology, two alternative therapies rooted in traditional Chinese medicine, have gained recognition for their potential to address sleep issues and alleviate associated symptoms.</div></div><div><h3>Methods</h3><div>This single blinded, three-groups randomized controlled trial was navigated at Tohid Hospital, involving 132 leukemia patients divided into acupuncture (<em>n</em> = 44), foot reflexology (<em>n</em> = 44), and control (<em>n</em> = 44) groups via random card selection. All patients completed a demographic questionnaire and the Pittsburgh Sleep Quality Index (PSQI) before the intervention. The acupuncture group received routine care along with twice-daily acupuncture at the SP6 point for four successive weeks. Reflexology group had daily ten-minute sittings for the same weeks using sweet almond oil on their feet. Control group continued by only routine cares. Post-intervention assessments were conducted using the same instruments after four weeks.</div></div><div><h3>Results</h3><div>The study analyzed patient demographics, finding no significant gender differences and a majority of high school graduates. All groups had similar proportions of singles, high employment rates, and urban residency. Average ages were comparable, with no significant pre-intervention sleep quality differences found. However, both acupuncture and reflexology groups showed significant improvements post-intervention, unlike the control group. While both interventions resulted in lower sleep quality scores compared to the control, no significant difference was observed between the acupuncture and reflexology groups. Trends indicated slight reductions in fatigue for the intervention groups, suggesting both therapies effectively improved sleep quality.</div></div><div><h3>Conclusion</h3><div>Acupuncture and foot reflexology are suggested as simple and budget-friendly complementary methods that may improve sleep quality for those with leukemia. These therapies provide non-invasive methods to address sleep disturbances and improve overall well-being in leukemia patients.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103101"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poor sleep quality due to pain, anxiety, and other surgical complications is a common challenge in postoperative patients. The present study aims to investigate the effect of postoperative slow-stroke back and hot stone massage therapy on the sleep quality of orthopedic surgery patients.
Methods
This randomized and controlled clinical trial was conducted on 99 patients in the postoperative period of orthopedic surgery. The participants were randomly distributed into three groups (slow-stroke back massage, hot stone massage, and routine care). On the first or second day after the surgery, one group received a slow-stroke back massage, and another received a hot stone massage in the morning and afternoon for 10-15 minutes. Demographic surveys and the Richard-Campbell Sleep Questionnaire (RCSQ) were used for data collection. Chi-square, Kruskal-Wallis, and Wilcoxon tests were used for analysis, and the desired significance level was considered < 0.05.
Results
There was a significant improvement in sleep quality scores of patients in the slow-stroke back or hot stone massage groups compared with the routine care group (p < 0.001) and also before intervention (p < 0.001).
Conclusion
The results suggest that slow-stroke back and hot stone massages can improve sleep quality in patients with orthopedic surgery in the postoperative period.
{"title":"The therapeutic effect of two different massages on the sleep quality of orthopedic surgery patients: A randomized controlled study","authors":"Morteza Hojat Ansari , Seyedeh Zahra Aemmi , Abbas Farhadi Faruji , Habibollah Esmaily","doi":"10.1016/j.explore.2024.103084","DOIUrl":"10.1016/j.explore.2024.103084","url":null,"abstract":"<div><h3>Objective</h3><div>Poor sleep quality due to pain, anxiety, and other surgical complications is a common challenge in postoperative patients. The present study aims to investigate the effect of postoperative slow-stroke back and hot stone massage therapy on the sleep quality of orthopedic surgery patients.</div></div><div><h3>Methods</h3><div>This randomized and controlled clinical trial was conducted on 99 patients in the postoperative period of orthopedic surgery. The participants were randomly distributed into three groups (slow-stroke back massage, hot stone massage, and routine care). On the first or second day after the surgery, one group received a slow-stroke back massage, and another received a hot stone massage in the morning and afternoon for 10-15 minutes. Demographic surveys and the Richard-Campbell Sleep Questionnaire (RCSQ) were used for data collection. Chi-square, Kruskal-Wallis, and Wilcoxon tests were used for analysis, and the desired significance level was considered < 0.05.</div></div><div><h3>Results</h3><div>There was a significant improvement in sleep quality scores of patients in the slow-stroke back or hot stone massage groups compared with the routine care group (p < 0.001) and also before intervention (p < 0.001).</div></div><div><h3>Conclusion</h3><div>The results suggest that slow-stroke back and hot stone massages can improve sleep quality in patients with orthopedic surgery in the postoperative period.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103084"},"PeriodicalIF":1.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although the prevalence of sexual dysfunction is high in menopausal women and it can cause many problems for them, it has been largely overlooked. The present study aimed to determine the effect of Rosa damascena extract capsules on the sexual function of menopausal women.
Materials and methods
This randomized, triple blinded clinical trial was conducted on 82 menopausal women who were randomly divided into two groups. In the intervention group, women took a capsule of Rosa damascena extract every 12 h for 8 weeks, while women in the placebo group took similar capsules without medicinal effects. The Female Sexual Function Index (FSFI) was evaluated before and after the intervention (4 and 8 weeks). The data were analyzed by SPSS software and statistical tests such as independent t-test, Mann‒Whitney U test, and Chi-square, with a significance level of 0.05.
Results
The use of Rosa damascena extract capsules significantly improved the total FSFI score four (P = 0.016) and eight weeks after the intervention (P < 0.001). The positive changes in FSFI domains in the intervention group were as follows: arousal, lubrication, satisfaction, and pain during intercourse four and eight weeks after the intervention. Additionally, desire and orgasm significantly increased eight weeks after the intervention (P < 0.05).
Conclusion
The results of this study indicate that Rosa damascena can improve sexual function in menopausal women. However, further studies are needed.
{"title":"Impact of Rosa damascena extract capsule on the sexual function of menopausal women: A randomized clinical trial","authors":"Zohreh Gholinezhad , Fatemeh Zahra Karimi , Hassan Rakhshandeh , Seyed Reza Mazloum","doi":"10.1016/j.explore.2024.103082","DOIUrl":"10.1016/j.explore.2024.103082","url":null,"abstract":"<div><h3>Objective</h3><div>Although the prevalence of sexual dysfunction is high in menopausal women and it can cause many problems for them, it has been largely overlooked. The present study aimed to determine the effect of <em>Rosa damascena</em> extract capsules on the sexual function of menopausal women.</div></div><div><h3>Materials and methods</h3><div>This randomized, triple blinded clinical trial was conducted on 82 menopausal women who were randomly divided into two groups. In the intervention group, women took a capsule of <em>Rosa damascena</em> extract every 12 h for 8 weeks, while women in the placebo group took similar capsules without medicinal effects. The Female Sexual Function Index (FSFI) was evaluated before and after the intervention (4 and 8 weeks). The data were analyzed by SPSS software and statistical tests such as independent <em>t</em>-test, Mann‒Whitney U test, and Chi-square, with a significance level of 0.05.</div></div><div><h3>Results</h3><div>The use of <em>Rosa damascena</em> extract capsules significantly improved the total FSFI score four (<em>P</em> = 0.016) and eight weeks after the intervention (<em>P</em> < 0.001). The positive changes in FSFI domains in the intervention group were as follows: arousal, lubrication, satisfaction, and pain during intercourse four and eight weeks after the intervention. Additionally, desire and orgasm significantly increased eight weeks after the intervention (<em>P</em> < 0.05).</div></div><div><h3>Conclusion</h3><div>The results of this study indicate that <em>Rosa damascena</em> can improve sexual function in menopausal women. However, further studies are needed.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103082"},"PeriodicalIF":1.9,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1016/j.explore.2024.103081
Jessica C. Nascimento , Vitória S. dos S. Gonçalves , Bruna R.S. Souza , Laranda de C. Nascimento , Betina M.R. de Carvalho , Paulo C.L. Nogueira , José P.S. Santos , Lysandro P. Borges , Tiago C. Goes , Jessiane Bispo de Souza , Henrique D.M. Coutinho , Adriana G. Guimarães
Introduction
Need to improve the quality of vaginal birth in a humanized and non-invasive way, contributing to pain and anxiety during labor. Integrative and complementary practices, such as aromatherapy, have been an important tool for managing natural birth. To evaluate the effects of Citrus sinensis L. aroma on pain and anxiety during labor.
Methods
Single-blind randomized clinical trial with pregnant women was performed in a city of Brazilian northwest. The pregnant women were divided (n=42/group) into an experimental group (inhalation of 250 μL of C. sinensis essential oil) and a placebo group (250 μL of distilled water), and submitted to the evaluation of pain intensity through Visual Analogic Scale, anxiety (STAI-E), physiological parameters, as well as fetal heart rate.
Results
Aromatherapy significantly reduced pain intensity over time (p=0.0411), especially for pregnant women in stage 1 dilatation and primiparous (p=0.0022). In addition, essential oil inhalation also reduced anxiety (p<0.0001), showing significant positive correlations (r=0.3147; p=0.3129) with pain intensity. Exposure to the aroma of sweet orange also reduced mean blood pressure, heart rate, respiratory rate of pregnant women and fetal heart rate (p<0.0001).
Discussion
The active compounds present in the essential oil used, especially limonene, are capable of modulating neurotransmission systems associated with pain and anxiety, being effective in reducing these symptoms during labor.
Conclusion
It was shown that C. sinensis essential oil reduces pain and anxiety during labor, indicating the potential of this type of intervention and its possible applicability in good labor practices.
{"title":"Effectiveness of aromatherapy with sweet orange oil (Citrus sinensis L.) in relieving pain and anxiety during labor","authors":"Jessica C. Nascimento , Vitória S. dos S. Gonçalves , Bruna R.S. Souza , Laranda de C. Nascimento , Betina M.R. de Carvalho , Paulo C.L. Nogueira , José P.S. Santos , Lysandro P. Borges , Tiago C. Goes , Jessiane Bispo de Souza , Henrique D.M. Coutinho , Adriana G. Guimarães","doi":"10.1016/j.explore.2024.103081","DOIUrl":"10.1016/j.explore.2024.103081","url":null,"abstract":"<div><h3>Introduction</h3><div>Need to improve the quality of vaginal birth in a humanized and non-invasive way, contributing to pain and anxiety during labor. Integrative and complementary practices, such as aromatherapy, have been an important tool for managing natural birth. To evaluate the effects of Citrus sinensis L. aroma on pain and anxiety during labor.</div></div><div><h3>Methods</h3><div>Single-blind randomized clinical trial with pregnant women was performed in a city of Brazilian northwest. The pregnant women were divided (n=42/group) into an experimental group (inhalation of 250 μL of <em>C. sinensis</em> essential oil) and a placebo group (250 μL of distilled water), and submitted to the evaluation of pain intensity through Visual Analogic Scale, anxiety (STAI-E), physiological parameters, as well as fetal heart rate.</div></div><div><h3>Results</h3><div>Aromatherapy significantly reduced pain intensity over time (p=0.0411), especially for pregnant women in stage 1 dilatation and primiparous (p=0.0022). In addition, essential oil inhalation also reduced anxiety (p<0.0001), showing significant positive correlations (r=0.3147; p=0.3129) with pain intensity. Exposure to the aroma of sweet orange also reduced mean blood pressure, heart rate, respiratory rate of pregnant women and fetal heart rate (p<0.0001).</div></div><div><h3>Discussion</h3><div>The active compounds present in the essential oil used, especially limonene, are capable of modulating neurotransmission systems associated with pain and anxiety, being effective in reducing these symptoms during labor.</div></div><div><h3>Conclusion</h3><div>It was shown that <em>C. sinensis</em> essential oil reduces pain and anxiety during labor, indicating the potential of this type of intervention and its possible applicability in good labor practices.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103081"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1016/j.explore.2024.103083
Zhao Peng, Duo Li, Na Wu, Xiao-Yuan Wang, Gai-Xia Sun, Hui-Bin Gao, Hai-Xia Li
Objective
This study aims to systematically evaluate the safety and efficacy of curcumin as an adjunctive treatment for patients with ulcerative colitis (UC) and to assess the methodological quality of the published studies.
Methods
A comprehensive search was conducted in PubMed, Embase, and CENTRAL databases for randomized controlled trials published up to August 18, 2023. Two independent reviewers screened studies based on predefined criteria. Meta-analysis was performed using a random-effects model with RevMan 5.4. Heterogeneity was assessed using Cochran's Q test and I² statistic.
Results
Eight randomized controlled trials involving 482 patients were included. Seven studies reported clinical remission, and three reported endoscopic remission. Compared to the placebo group, adjunctive curcumin therapy significantly improved clinical remission (RR=2.33, 95 % CI: 1.25 to 4.34; P = 0.008; I²=80 %). Although endoscopic remission showed an increasing trend, it was not statistically significant (RR=4.17, 95 % CI: 0.63 to 27.71; P = 0.14; I²=80 %). Significant improvements were also observed in clinical improvement (RR=1.93, 95 % CI: 1.10 to 3.36; P = 0.02; I²=56 %) and endoscopic improvement (RR=1.76, 95 % CI: 1.12 to 2.77; P = 0.01; I²=62 %) in the curcumin group. No serious adverse events were reported. Subgroup analysis indicated a positive correlation between treatment efficacy and dosage, with no significant impact of administration method or follow-up duration on the pooled results or heterogeneity.
Conclusion
Curcumin as an adjunctive treatment shows promise in improving clinical and endoscopic outcomes in UC patients without significant adverse effects. However, due to the limited number of studies and substantial heterogeneity, further large-scale randomized controlled trials are necessary to confirm these findings.
{"title":"Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled trials","authors":"Zhao Peng, Duo Li, Na Wu, Xiao-Yuan Wang, Gai-Xia Sun, Hui-Bin Gao, Hai-Xia Li","doi":"10.1016/j.explore.2024.103083","DOIUrl":"10.1016/j.explore.2024.103083","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to systematically evaluate the safety and efficacy of curcumin as an adjunctive treatment for patients with ulcerative colitis (UC) and to assess the methodological quality of the published studies.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Embase, and CENTRAL databases for randomized controlled trials published up to August 18, 2023. Two independent reviewers screened studies based on predefined criteria. Meta-analysis was performed using a random-effects model with RevMan 5.4. Heterogeneity was assessed using Cochran's Q test and I² statistic.</div></div><div><h3>Results</h3><div>Eight randomized controlled trials involving 482 patients were included. Seven studies reported clinical remission, and three reported endoscopic remission. Compared to the placebo group, adjunctive curcumin therapy significantly improved clinical remission (RR=2.33, 95 % CI: 1.25 to 4.34; <em>P</em> = 0.008; I²=80 %). Although endoscopic remission showed an increasing trend, it was not statistically significant (RR=4.17, 95 % CI: 0.63 to 27.71; <em>P</em> = 0.14; I²=80 %). Significant improvements were also observed in clinical improvement (RR=1.93, 95 % CI: 1.10 to 3.36; <em>P</em> = 0.02; I²=56 %) and endoscopic improvement (RR=1.76, 95 % CI: 1.12 to 2.77; <em>P</em> = 0.01; I²=62 %) in the curcumin group. No serious adverse events were reported. Subgroup analysis indicated a positive correlation between treatment efficacy and dosage, with no significant impact of administration method or follow-up duration on the pooled results or heterogeneity.</div></div><div><h3>Conclusion</h3><div>Curcumin as an adjunctive treatment shows promise in improving clinical and endoscopic outcomes in UC patients without significant adverse effects. However, due to the limited number of studies and substantial heterogeneity, further large-scale randomized controlled trials are necessary to confirm these findings.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103083"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-10DOI: 10.1016/j.explore.2024.103076
Yige Liu , Feng Du , Bo Chen , Sanjay Rastogi , Yanhua Huang
Background
Elemene is a naturally occurring chemical derived from plants of the Zingiberaceae family, and it finds application in several cancer-related contexts. Nevertheless, there is a dearth of comprehensive assessment about the combined effectiveness and safety of chemotherapy in gastric cancer (GC).
Objective
To investigate the safety and effectiveness of elemene in conjunction with chemotherapy for the treatment of Gastric cancer.
Methods
A comprehensive search of Medline, EMBASE, Scopus, and Cochrane Library identified peer-reviewed journal papers. OR and RR were calculated, along with their 95 % confidence ranges. We assessed heterogeneity using Cochrane Q and I2 statistics and the relevant P-value. The analysis used RevMan 5.3.
Results
Current meta-analysis includes 11 RCTs with 726 GC patients, 364 of whom received elemene paired with treatment and 362 received standard chemotherapy. Elemene-coated chemotherapy improves ORR (RR 1.43, 95 % CI 1.22–1.67, p < 0.00001), reduces blood system toxicity (OR 0.49, 95 % CI 0.35–0.69, p < 0.0001), nausea and vomiting (RR 0.65, 95 % CI 0.55–0.77), diarrhea (RR 0.73, 95 % CI 0.58–0.90), and liver problems (RR 0.64, 95 % CI 0.49–0.83).Subgroup analysis showed that both oral and intravenous administration improved ORR statistically, and a network diagram with consistent connectivity, well-defined network architecture, and high-quality evidence shows that elemene combined with chemotherapy has significant therapeutic efficacy.
Conclusion
Elemene may possess the capacity to enhance the effectiveness and mitigate the adverse effects of gastric cancer chemotherapy. Nevertheless, due to the restricted number of studies incorporated, additional research studies utilizing sizable samples are required to validate the aforementioned findings
delemene是一种从姜科植物中提取的天然化学物质，它在几种与癌症相关的环境中得到应用。然而，目前缺乏对胃癌化疗的综合有效性和安全性的综合评价。目的探讨榄香烯联合化疗治疗胃癌的安全性和有效性。方法综合检索Medline、EMBASE、Scopus和Cochrane图书馆的同行评议期刊论文。计算OR和RR，以及它们的95%置信范围。我们使用Cochrane Q和I2统计量及相关p值评估异质性。分析使用RevMan 5.3。结果11项随机对照试验共纳入726例胃癌患者，其中364例接受榄香烯联合治疗，362例接受标准化疗。榄烯烯包被化疗改善ORR (RR 1.43, 95% CI 1.22-1.67, p <；0.00001)，降低血液系统毒性(OR 0.49, 95% CI 0.35-0.69, p <；0.0001)、恶心和呕吐（RR 0.65, 95% CI 0.55-0.77）、腹泻（RR 0.73, 95% CI 0.58-0.90）和肝脏问题（RR 0.64, 95% CI 0.49-0.83）。亚组分析结果显示，口服和静脉给药均有统计学意义上的改善ORR，连通性一致、网络结构明确、证据质量高的网络图显示榄香烯联合化疗疗效显著。结论榄香烯可能具有提高胃癌化疗疗效和减轻化疗不良反应的作用。然而，由于纳入的研究数量有限，需要使用大量样本的额外研究来验证上述发现
{"title":"A meta-analysis of randomized controlled trials examining the efficacy and safety of elemene in combination with chemotherapy for the treatment of gastric cancer","authors":"Yige Liu , Feng Du , Bo Chen , Sanjay Rastogi , Yanhua Huang","doi":"10.1016/j.explore.2024.103076","DOIUrl":"10.1016/j.explore.2024.103076","url":null,"abstract":"<div><h3>Background</h3><div>Elemene is a naturally occurring chemical derived from plants of the Zingiberaceae family, and it finds application in several cancer-related contexts. Nevertheless, there is a dearth of comprehensive assessment about the combined effectiveness and safety of chemotherapy in gastric cancer (GC).</div></div><div><h3>Objective</h3><div>To investigate the safety and effectiveness of elemene in conjunction with chemotherapy for the treatment of Gastric cancer.</div></div><div><h3>Methods</h3><div>A comprehensive search of Medline, EMBASE, Scopus, and Cochrane Library identified peer-reviewed journal papers. OR and RR were calculated, along with their 95 % confidence ranges. We assessed heterogeneity using Cochrane Q and I2 statistics and the relevant P-value. The analysis used RevMan 5.3.</div></div><div><h3>Results</h3><div>Current meta-analysis includes 11 RCTs with 726 GC patients, 364 of whom received elemene paired with treatment and 362 received standard chemotherapy. Elemene-coated chemotherapy improves ORR (RR 1.43, 95 % CI 1.22–1.67, p < 0.00001), reduces blood system toxicity (OR 0.49, 95 % CI 0.35–0.69, p < 0.0001), nausea and vomiting (RR 0.65, 95 % CI 0.55–0.77), diarrhea (RR 0.73, 95 % CI 0.58–0.90), and liver problems (RR 0.64, 95 % CI 0.49–0.83).Subgroup analysis showed that both oral and intravenous administration improved ORR statistically, and a network diagram with consistent connectivity, well-defined network architecture, and high-quality evidence shows that elemene combined with chemotherapy has significant therapeutic efficacy.</div></div><div><h3>Conclusion</h3><div>Elemene may possess the capacity to enhance the effectiveness and mitigate the adverse effects of gastric cancer chemotherapy. Nevertheless, due to the restricted number of studies incorporated, additional research studies utilizing sizable samples are required to validate the aforementioned findings</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103076"},"PeriodicalIF":1.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this case report, we describe the successful treatment of a patient with complete small bowel obstruction following gastric cancer surgery, employing an integrated approach of traditional Chinese medicine and Western medicine. Initial treatment consisted of conventional biomedical interventions, including intestinal obstruction catheterization, but after 16 days without improvement, surgical intervention was recommended. The patient, however, refused surgery and opted for treatments based on traditional Chinese medicine. Comprehensive traditional Chinese medicine therapies such as acupuncture, moxibustion, flash cupping, oral administration of compound herbal formulas, and enemas using Chinese herbal medicine were implemented alongside modern medical care. The obstruction resolved, and the patient was discharged without requiring surgery. Follow-up revealed no recurrence of the condition. This case highlights the potential of integrating traditional Chinese medicine with Western medical practices in the conservative management of complete small bowel obstruction, offering a reference for clinical application.
{"title":"Efficacy of traditional Chinese medicine in the conservative management of complete small intestinal obstruction post-gastric cancer surgery: A case report","authors":"Weipeng Zhao , Jian Xun , Xinyu Yuan , Jinchang Huang , Jing Bai","doi":"10.1016/j.explore.2024.103080","DOIUrl":"10.1016/j.explore.2024.103080","url":null,"abstract":"<div><div>In this case report, we describe the successful treatment of a patient with complete small bowel obstruction following gastric cancer surgery, employing an integrated approach of traditional Chinese medicine and Western medicine. Initial treatment consisted of conventional biomedical interventions, including intestinal obstruction catheterization, but after 16 days without improvement, surgical intervention was recommended. The patient, however, refused surgery and opted for treatments based on traditional Chinese medicine. Comprehensive traditional Chinese medicine therapies such as acupuncture, moxibustion, flash cupping, oral administration of compound herbal formulas, and enemas using Chinese herbal medicine were implemented alongside modern medical care. The obstruction resolved, and the patient was discharged without requiring surgery. Follow-up revealed no recurrence of the condition. This case highlights the potential of integrating traditional Chinese medicine with Western medical practices in the conservative management of complete small bowel obstruction, offering a reference for clinical application.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103080"},"PeriodicalIF":1.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nocturnal enuresis (NE) is a very common problem in childhood. The prevalence rate varies from 3.5% to 56.4% in different geographical regions and countries.
Objective
Homeopathy is claimed to be a safe and effective mode of complementary and alternative therapy; however, robust research evidence supporting the efficacy or effectiveness of homeopathy in NE is scarce. This trial aimed at detecting the group differences between homeopathy and placebo in the treatment of NE in children.
Pediatric outpatient department of D. N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal.
Patients
One hundred and forty children suffering from NE.
Interventions
Active treatment (individualized homeopathic medicinal products, IHMPs plus concomitant care, CC; n = 70) versus control (identical-looking placebos, plus CC; n = 70).
Main outcome measures
Primary – the frequency of bedwetting events between groups; secondary – the pediatric quality of life inventory (PedsQL, version 4.0) questionnaire and its subscales – child-rated and parent-rated versions; all were measured at baseline, and every month, up to 3 months.
Results
After 3 months of intervention, group differences were statistically significant in the primary outcome favoring IHMPs against placebo (median difference: 2.4, interquartile range -4 to 9.7, Mann Whitney U = 1956.5, p = 0.039). Although the intra-group median reductions were higher in the IHMPs group than in placebos, the differences were statistically non-significant in the secondary outcome – PedsQL total child report version (p = 0.224) and PedsQL total parent report version (p = 0.942). Sulphur (n = 26, 18.6%), Calcarea phosphorica (n = 20, 14.3%), Calcarea carbonica and Kreosotum (n = 9 each, 6.4%), and Mercurius solubilis (n = 8, 5.7%) were the most frequently prescribed medicines. Thus, IHMPs were found superior to placebos in reducing the frequency of bedwetting events in children. Independent replications are warranted to substantiate the findings.
Clinical Trials Registry – India CTRI/2022/04/042009.
{"title":"A double-blind, randomized, placebo-controlled trial of individualized homeopathic medicinal products in the treatment of nocturnal enuresis in children","authors":"Junayed Akram , Arpita Basu , Md. Sakhawat Hossain , Soumya Bhattacharyya , Saima Shamim , Pintu Debnath , Rizwana Rahaman , Sourav Goswami , Usashi Nag , Priyanka Ghosh , Abdur Rahaman Shaikh , Chandrima Chatterjee , Munmun Koley , Subhranil Saha , Sangita Saha , Shyamal Kumar Mukherjee","doi":"10.1016/j.explore.2024.103077","DOIUrl":"10.1016/j.explore.2024.103077","url":null,"abstract":"<div><h3>Context</h3><div>Nocturnal enuresis (NE) is a very common problem in childhood. The prevalence rate varies from 3.5% to 56.4% in different geographical regions and countries.</div></div><div><h3>Objective</h3><div>Homeopathy is claimed to be a safe and effective mode of complementary and alternative therapy; however, robust research evidence supporting the efficacy or effectiveness of homeopathy in NE is scarce. This trial aimed at detecting the group differences between homeopathy and placebo in the treatment of NE in children.</div></div><div><h3>Design</h3><div>Three-month, double-blind, randomized (1:1), placebo-controlled trial.</div></div><div><h3>Setting</h3><div>Pediatric outpatient department of D. N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal.</div></div><div><h3>Patients</h3><div>One hundred and forty children suffering from NE.</div></div><div><h3>Interventions</h3><div>Active treatment (individualized homeopathic medicinal products, IHMPs plus concomitant care, CC; <em>n</em> = 70) versus control (identical-looking placebos, plus CC; <em>n</em> = 70).</div></div><div><h3>Main outcome measures</h3><div>Primary – the frequency of bedwetting events between groups; secondary – the pediatric quality of life inventory (PedsQL, version 4.0) questionnaire and its subscales – child-rated and parent-rated versions; all were measured at baseline, and every month, up to 3 months.</div></div><div><h3>Results</h3><div>After 3 months of intervention, group differences were statistically significant in the primary outcome favoring IHMPs against placebo (median difference: 2.4, interquartile range -4 to 9.7, Mann Whitney <em>U</em> = 1956.5, <em>p</em> = 0.039). Although the intra-group median reductions were higher in the IHMPs group than in placebos, the differences were statistically non-significant in the secondary outcome – PedsQL total child report version (<em>p</em> = 0.224) and PedsQL total parent report version (<em>p</em> = 0.942). <em>Sulphur</em> (<em>n</em> = 26, 18.6%), <em>Calcarea phosphorica</em> (<em>n</em> = 20, 14.3%), <em>Calcarea carbonica</em> and <em>Kreosotum</em> (<em>n</em> = 9 each, 6.4%)<em>,</em> and <em>Mercurius solubilis</em> (<em>n</em> = 8, 5.7%) were the most frequently prescribed medicines. Thus, IHMPs were found superior to placebos in reducing the frequency of bedwetting events in children. Independent replications are warranted to substantiate the findings.</div><div>Clinical Trials Registry – India CTRI/2022/04/042009.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 1","pages":"Article 103077"},"PeriodicalIF":1.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and purpose: Baduanjin qigong exercises have previously been reported to improve Ankylosing Spondylitis (AS) symptoms. The aim of this study was to examine the effectiveness of 12-week Baduanjin qigong exercises in patients with AS.
Method: Fifty-nine patients with AS aged 18-64 were included in the study. The participants were divided into two groups. The intervention group performed Baduanjin qigong online exercise program, control group received home exercises for 45 min twice a week for 12 weeks. Before and after the 12-week exercise program, patients were evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)-Functional Index (BASFI)-Metrology Index (BASMI), chest expansion measurement, Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), and Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL).
Results: When the groups were compared after the intervention, there was a significant difference in favor of the intervention group in the BASMI (p: 0.00-0.04), FSS (p:0.01), and chest expansion (p:0.04). Also, the delta values of the groups were compared; the intervention group was found to be superior in terms of PSQI (p:0.01), BASFI (p:0.00), and BASMI (p:0.04).
Conclusion: Baduanjin qigong should be added to rehabilitation programs as a complementary method to improve fatigue levels, chest expansion, flexibility, functionality, and quality of life in patients with AS.
{"title":"The effects of baduanjin qigong exercise via telerehabilitation in ankylosing spondylitis: A randomized controlled study.","authors":"Gokce Yagmur Gunes Gencer, Sebahat Yaprak Cetin, Duygu Sanem Kara, Saniye Yardim, Ayse Ayan","doi":"10.1016/j.explore.2024.103078","DOIUrl":"https://doi.org/10.1016/j.explore.2024.103078","url":null,"abstract":"<p><strong>Background and purpose: </strong>Baduanjin qigong exercises have previously been reported to improve Ankylosing Spondylitis (AS) symptoms. The aim of this study was to examine the effectiveness of 12-week Baduanjin qigong exercises in patients with AS.</p><p><strong>Method: </strong>Fifty-nine patients with AS aged 18-64 were included in the study. The participants were divided into two groups. The intervention group performed Baduanjin qigong online exercise program, control group received home exercises for 45 min twice a week for 12 weeks. Before and after the 12-week exercise program, patients were evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)-Functional Index (BASFI)-Metrology Index (BASMI), chest expansion measurement, Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), and Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL).</p><p><strong>Results: </strong>When the groups were compared after the intervention, there was a significant difference in favor of the intervention group in the BASMI (p: 0.00-0.04), FSS (p:0.01), and chest expansion (p:0.04). Also, the delta values of the groups were compared; the intervention group was found to be superior in terms of PSQI (p:0.01), BASFI (p:0.00), and BASMI (p:0.04).</p><p><strong>Conclusion: </strong>Baduanjin qigong should be added to rehabilitation programs as a complementary method to improve fatigue levels, chest expansion, flexibility, functionality, and quality of life in patients with AS.</p>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":" ","pages":"103078"},"PeriodicalIF":1.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-01DOI: 10.1016/j.explore.2024.103075
Shairy Quimbo , Lorena de la Torre Parra
<div><div>Ñukami Taky Samy ñan kani, Taky Samy shimika ñukapak Ñawpa Kichwa shimimi kan, Taky nishpaka ñuka kikin shimiwan takini, takinakunawanpash takini, wiwakunapash, pishkukunapash, takinkunami, Samy, ushay samy, kawsay samy, shinchi samy, jampi samy. Takysamywanka nanaykunata, llakikunata, piñaykunata jampita ushanchik, ñukanchipak allpa kamashkata jampinata ushanchik, llaki kawsayta, wakcha kawsaytapash jampita ushanchik. Taky Samytak takipashunchik, jukipushunchik, arawishunchik, tushushunchik, willkarishunchik. Kari Karilla, wawakuna, wambrakuna, kuitrsakuna wiñarishunchik, mushukyashunchik. Taky Samywanmi, ñukanchik wawakunatak shutichipashunchik, warachipashunchik, sawachipashunchik, Hawa pachaman Wantiyayta takishpa, muyushpa tikrapashunchik, allpa mamaman willkapashunchik, Inti Raymipik Tushupashunchik, chashnami tsirwikunawan, Manka shimikunawan, sampoñakunawan, pallakunawan, kuntur pinkullukunawan, wankarkunawan, tuntullikunawan, tinyakunawan, kenakunawan, churukunawan, kipakunawan, chillchillkunawan kuyaylla, munaylla, kushilla, punchalla kawsana kapanchik kay mushuk pachapi, tukuilla pachamamawan mushukyaspa kawsapashunchik. shina kachun tukuy llactakunamanta runakuna.</div></div><div><div>Taky Samy is an ancestral Andean healing practice of our physical, mental, emotional, spiritual, and auric bodies. Taky Samy practices connect us with plants, animals, birds and Mother Earth, through the language of instruments made of ceramic, bamboo, deer, and condor feathers and bones. These practices are guided by the sacred word of prayer, mantras and songs that connect with the Great Ordering Spirit Pachakamak, and the Great Mystery Tunupa Tixi Wirakocha, so that we can return to the order of life in harmony with all the beings of Mother Earth. Mother Earth has her order and that order guides all the activities of our lives. This order is represented in the cycles of the cultivation of our crops: corn in the first order, accompanied by potatoes, beans, quinua, chochos, pumpkins, and so on. Mother Earth cycles lead all Raymi and Andean rituals and festive celebrations, such as the solar dances that are accompanied by corn chicha, this includes the practice of Taky Samy ceremonies, music and dances. Taky Samy is more than musical therapy, it is harmony of life. Its therapeutic attributes and sacred language can heal an array of ailments and can also prevent adverse personal and family situations. Taky Samy celebrates social harmony and wards off illnesses and bad luck. It ultimately connects society with the Buen Vivir or Good Living, the Sumak Kawsay, which is a legacy of our Andean ancestors. This paper touches on the origins, purpose and practices of Taky Samy as important elements of the tapestry of ancestral Andean healing rituals. It focuses on Tayta Shairy Quimbo's (this paper's first author) Taky Samy path and practices. Taky Samy sacred instruments and spaces, as well as healing word and practices, connect us with spiritual worlds,
{"title":"Ancestral healing rituals and the significance of Taky Samy in andean spirituality","authors":"Shairy Quimbo , Lorena de la Torre Parra","doi":"10.1016/j.explore.2024.103075","DOIUrl":"10.1016/j.explore.2024.103075","url":null,"abstract":"<div><div>Ñukami Taky Samy ñan kani, Taky Samy shimika ñukapak Ñawpa Kichwa shimimi kan, Taky nishpaka ñuka kikin shimiwan takini, takinakunawanpash takini, wiwakunapash, pishkukunapash, takinkunami, Samy, ushay samy, kawsay samy, shinchi samy, jampi samy. Takysamywanka nanaykunata, llakikunata, piñaykunata jampita ushanchik, ñukanchipak allpa kamashkata jampinata ushanchik, llaki kawsayta, wakcha kawsaytapash jampita ushanchik. Taky Samytak takipashunchik, jukipushunchik, arawishunchik, tushushunchik, willkarishunchik. Kari Karilla, wawakuna, wambrakuna, kuitrsakuna wiñarishunchik, mushukyashunchik. Taky Samywanmi, ñukanchik wawakunatak shutichipashunchik, warachipashunchik, sawachipashunchik, Hawa pachaman Wantiyayta takishpa, muyushpa tikrapashunchik, allpa mamaman willkapashunchik, Inti Raymipik Tushupashunchik, chashnami tsirwikunawan, Manka shimikunawan, sampoñakunawan, pallakunawan, kuntur pinkullukunawan, wankarkunawan, tuntullikunawan, tinyakunawan, kenakunawan, churukunawan, kipakunawan, chillchillkunawan kuyaylla, munaylla, kushilla, punchalla kawsana kapanchik kay mushuk pachapi, tukuilla pachamamawan mushukyaspa kawsapashunchik. shina kachun tukuy llactakunamanta runakuna.</div></div><div><div>Taky Samy is an ancestral Andean healing practice of our physical, mental, emotional, spiritual, and auric bodies. Taky Samy practices connect us with plants, animals, birds and Mother Earth, through the language of instruments made of ceramic, bamboo, deer, and condor feathers and bones. These practices are guided by the sacred word of prayer, mantras and songs that connect with the Great Ordering Spirit Pachakamak, and the Great Mystery Tunupa Tixi Wirakocha, so that we can return to the order of life in harmony with all the beings of Mother Earth. Mother Earth has her order and that order guides all the activities of our lives. This order is represented in the cycles of the cultivation of our crops: corn in the first order, accompanied by potatoes, beans, quinua, chochos, pumpkins, and so on. Mother Earth cycles lead all Raymi and Andean rituals and festive celebrations, such as the solar dances that are accompanied by corn chicha, this includes the practice of Taky Samy ceremonies, music and dances. Taky Samy is more than musical therapy, it is harmony of life. Its therapeutic attributes and sacred language can heal an array of ailments and can also prevent adverse personal and family situations. Taky Samy celebrates social harmony and wards off illnesses and bad luck. It ultimately connects society with the Buen Vivir or Good Living, the Sumak Kawsay, which is a legacy of our Andean ancestors. This paper touches on the origins, purpose and practices of Taky Samy as important elements of the tapestry of ancestral Andean healing rituals. It focuses on Tayta Shairy Quimbo's (this paper's first author) Taky Samy path and practices. Taky Samy sacred instruments and spaces, as well as healing word and practices, connect us with spiritual worlds,","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"20 6","pages":"Article 103075"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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