Explore-The Journal of Science and Healing最新文献

英文中文

Comparison of the effect of ice sucking containing peppermint (Mentha piperita L.) with cardamom (Elettaria cardamomum) extract on nausea, vomiting, and drug request after laparoscopic cholecystectomy 含薄荷冰吸与豆蔻提取物冰吸对腹腔镜胆囊切除术后恶心、呕吐及用药需求的影响比较。

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-09 DOI: 10.1016/j.explore.2025.103261

Nahid Kamalvand , Morteza Shamsizadeh , Leili Tapak , Azim Azizi

Background

Postoperative nausea and vomiting (PONV) are common and distressing complications following laparoscopic cholecystectomy. This study evaluated the efficacy of sublingual peppermint (Mentha piperita L., M. piperita) and cardamom (Elettaria cardamomum, E. cardamomum) extract ice cubes in alleviating these symptoms and reducing the requirement for rescue antiemetics.

Methods

In this triple-blinded randomized controlled trial, 105 patients scheduled for elective laparoscopic cholecystectomy were enrolled. Participants were randomly allocated to one of three groups: M. piperita, E. cardamomum, or placebo. Following baseline assessment, the intervention consisted of four sublingual administrations (every 15 min) of a 1-cm ice cube. For the active groups, each ice cube was impregnated with six drops of 10 % essential oil extract. The primary outcome was nausea severity, measured by a Visual Analogue Scale (VAS) at baseline, 1 hour, and 3 h post-intervention. Secondary outcomes included the frequency of vomiting episodes and requests for antiemetic medication, recorded over a 4-hour postoperative period.

Results

While trends indicated a greater reduction in nausea severity, vomiting frequency, and antiemetic demand in the M. piperita group compared to the E. cardamomum group, the intergroup differences were not statistically significant (p > 0.05). Both intervention groups reported improved outcomes over the placebo group.

Conclusions

The sublingual application of M. piperita or E. cardamomum extract ice cubes presents a simple, safe, and effective non-pharmacological adjunct for managing PONV in patients recovering from laparoscopic cholecystectomy.

背景：术后恶心和呕吐（PONV）是腹腔镜胆囊切除术后常见且令人痛苦的并发症。本研究评估舌下薄荷（Mentha piperita L.， M. piperita）和小豆蔻（Elettaria cardamomum， E. cardamomum）提取物冰块在缓解这些症状和减少急救止吐药需求方面的疗效。方法：在这项三盲随机对照试验中，纳入了105例计划择期腹腔镜胆囊切除术的患者。参与者被随机分配到三组中的一组：辣椒、豆蔻和安慰剂。基线评估后，干预包括四次舌下给药（每15分钟一次）1厘米冰块。对于活性组，每个冰块浸渍6滴10%的精油提取物。主要结局是恶心严重程度，通过视觉模拟量表（VAS）在基线、干预后1小时和3小时进行测量。次要结局包括术后4小时记录的呕吐次数和止吐药物的使用情况。结果：虽然趋势表明，与豆蔻粉组相比，胡椒豆蔻粉组在恶心严重程度、呕吐频率和止吐需求方面有更大的降低，但组间差异无统计学意义（p < 0.05）。两个干预组都报告了比安慰剂组更好的结果。结论：舌下应用胡椒或豆蔻提取物冰块是一种简单、安全、有效的非药物辅助治疗腹腔镜胆囊切除术后恢复期PONV的方法。

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引用次数: 0

Integrative medicine consults in a pediatric hospital: A case series 儿科医院的综合医学咨询：一个案例系列

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-06 DOI: 10.1016/j.explore.2025.103259

Ila Kaul , Ken Busby , Ann Ming Yeh

Pediatric integrative medicine (PIM) is a holistic approach to health care that combines conventional pediatric treatments with evidence-based complementary therapies to support the physical, emotional, and spiritual well-being of children and their caretakers. It encompasses a wide range of modalities, including acupuncture, massage therapy, mindfulness, guided imagery, and nutritional counseling, tailored to meet the developmental and medical needs of pediatric patients. The goal of PIM is to support treatment by integrating family values, lifestyle, and stress management into care plans through different therapies. In this report, the existing literature of pediatric inpatient integrative medicine interventions is reviewed, and three patient case studies illustrate the impact of a pilot integrative medicine consultation service in a tertiary care children’s hospital. These cases will reflect integrative medicine modalities to provide non-pharmacologic symptom management through approaches such as massage, acupressure, clinical hypnosis, guided imagery, and breathing techniques.

儿科综合医学（PIM）是一种全面的医疗保健方法，将传统的儿科治疗与循证补充疗法相结合，以支持儿童及其照顾者的身体、情感和精神健康。它涵盖了广泛的模式，包括针灸，按摩疗法，正念，引导图像和营养咨询，量身定制，以满足儿科患者的发展和医疗需求。PIM的目标是通过不同的治疗方法，将家庭价值观、生活方式和压力管理整合到护理计划中，从而支持治疗。在本报告中，回顾了现有的关于儿科住院中西医结合干预的文献，并通过三个患者案例说明了在三级保健儿童医院试点中西医结合咨询服务的影响。这些病例将反映综合医学模式，通过按摩、穴位按压、临床催眠、引导意象和呼吸技术等方法提供非药物症状管理。

引用次数: 0

Traditional Chinese medicine combined with biologic therapy for refractory severe ulcerative colitis: A case report 中药结合生物疗法治疗难治性重度溃疡性结肠炎1例

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-06 DOI: 10.1016/j.explore.2025.103260

Pengfei Tian, Mingdian Lu

Background

Acute severe ulcerative colitis (UC) may show suboptimal early response to corticosteroids and biologics, with ongoing hematochezia and anemia increasing the risk of rescue failure and surgery. Traditional Chinese medicine (TCM) is used adjunctively in East Asia and may aid hemostasis, barrier repair, and symptom control; however, evidence for timing and integration with biologic induction remains limited.

Case summary

An 18-year-old man with extensive, severe UC (Mayo 12; endoscopic Mayo 3) had only partial improvement after intravenous steroids and two infliximab (IFX) infusions, with persistent hematochezia and a hemoglobin nadir of 59 g/L. A modified TCM regimen (Shen-Ling-Bai-Zhu San plus Ge-Gen-Qin-Lian Tang) was started, achieving a hemostatic “inflection” within 3–4 days; Huangtu Tang–intent herbs were added for recurrent bleeding. IFX was then accelerated with a third infusion at week 2. By discharge, symptoms remitted (Mayo 2; Lichtiger 2), and by day-14 endoscopy the mucosa improved (endoscopic Mayo 1). At two months, clinical indices were 0 with normalized C-reactive protein and sustained remission thereafter. No new serious adverse events occurred during combination therapy.

Conclusions

In steroid-refractory severe UC with inadequate early bleeding control during IFX induction, adjunctive TCM—combined with accelerated IFX—was temporally associated with rapid hemostasis, clinical improvement, and endoscopic healing without new safety signals. This case supports the feasibility of an integrative, treat-to-target strategy and highlights the need for standardized protocols and prospective trials to validate efficacy and clarify mechanisms.

急性严重溃疡性结肠炎（UC）可能对皮质类固醇和生物制剂的早期反应不理想，持续的便血和贫血增加了抢救失败和手术的风险。在东亚地区，中医是辅助用药，可以帮助止血、修复屏障和控制症状；然而，与生物诱导的时间和整合的证据仍然有限。一例18岁男性广泛、严重UC （Mayo 12；内镜下Mayo 3）在静脉注射类固醇和两次英夫利昔单抗（IFX）后仅部分改善，持续便血，血红蛋白最低为59 g/L。开始中药改良方案（参苓白珠散加葛根芩连汤），3-4天止血“屈曲”；复发性出血加以黄土汤为主的中药。然后在第2周第三次输注IFX加速。出院时症状缓解（Mayo 2; Lichtiger 2），第14天内镜检查粘膜改善（内镜Mayo 1）。2个月时，临床指标为0，c反应蛋白正常，此后持续缓解。联合治疗期间未发生新的严重不良事件。结论对于激素难治性重度UC，在IFX诱导早期出血控制不充分的情况下，辅助中药联合加速IFX与快速止血、临床改善和内镜下愈合暂时相关，且无新的安全信号。该病例支持了一种综合的、从治疗到目标的策略的可行性，并强调了标准化方案和前瞻性试验的必要性，以验证疗效和阐明机制。

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引用次数: 0

A journey within: Reflections on sleep apnea, evolution, and the mind-body axis in sleep medicine 内心之旅：睡眠医学中关于睡眠呼吸暂停、进化和身心轴的思考

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-05 DOI: 10.1016/j.explore.2025.103255

Nimit Khara

This reflective travelogue explores obstructive sleep apnea (OSA) as more than a physiological disorder, framing it within evolutionary, psychosomatic, and cultural dimensions. It examines how human bipedalism and sleep posture may predispose to OSA, while drawing parallels with animal observations and ancient traditions. Symbolic interpretations of sleeping positions highlight the interplay of mind, body, and consciousness. The essay critiques CPAP therapy as effective yet mechanistic, envisioning integrative approaches combining modern science with mindfulness, yoga, and chronobiological practices. Ultimately, it calls for a holistic vision of sleep medicine that harmonizes evidence-based interventions with timeless wisdom.

这篇发人深省的游记探讨了阻塞性睡眠呼吸暂停（OSA）不仅仅是一种生理障碍，而是从进化、身心和文化的角度来看待它。它研究了人类的两足行走和睡眠姿势如何使人易患阻塞性睡眠呼吸暂停，同时与动物观察和古代传统进行了比较。对睡眠姿势的象征性解释强调了思想、身体和意识的相互作用。这篇文章批评CPAP治疗是有效但机械的，它设想了将现代科学与正念、瑜伽和时间生物学实践相结合的综合方法。最终，它要求对睡眠医学有一个整体的看法，使循证干预与永恒的智慧相协调。

引用次数: 0

The spiraling decline of American healthcare, its politicization, and the failure of the illness profit system 美国医疗保健的螺旋式下降，它的政治化，以及疾病利润体系的失败

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-04 DOI: 10.1016/j.explore.2025.103246

Stephan A. Schwartz

引用次数: 0

Uncatalogued flora and patient harm: Reassessing the use of traditional herbs in clinical contexts 未分类的菌群和病人的伤害：重新评估在临床环境中使用传统草药

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-03 DOI: 10.1016/j.explore.2025.103256

Adeeba Bilquees , Mohd Aamir , Daood Saleem

引用次数: 0

Efficacy and safety of scalp acupuncture in the treatment of Tic disorders in children: A meta-analysis based on randomized controlled trials 头皮针刺治疗儿童抽动障碍的疗效和安全性：基于随机对照试验的荟萃分析

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-01 DOI: 10.1016/j.explore.2025.103242

Haijiao Lin , Xiangyu Chen , Zhongtian Wang , Liping Sun

Aim

This study evaluates the efficacy and safety of scalp acupuncture in treating tic disorders.

Methods

We conducted a meta-analysis using data from 19 randomized controlled trials (RCTs) involving 1463 patients, sourced from various databases up to May 16, 2023. Stata15.0 was used to assess clinical efficacy rate, YGTSS score, TCM syndrome score, adverse reactions, and long-term efficacy.

Results

Scalp acupuncture significantly reduced YGTSS and TCM syndrome scores and improved clinical efficacy rates compared to controls [YGTSS: RR=-3.54, 95 % CI (-5.16, -1.93), P < 0.05; TCM: RR=-1.86, 95 % CI (-2.60, -1.13), P < 0.05; Efficacy: RR=1.14, 95 % CI (1.06, 1.23), P < 0.05]. Adverse reaction rates were lower in the treatment group (7.29 % vs. 12.61 % in controls), but not statistically significant [OR=0.69, 95 % CI (0.40, 1.18), P > 0.005]. Long-term efficacy was also stable [RR=-1.98, 95 % CI (-3.57, -0.39), P < 0.05].

Conclusion

Scalp acupuncture is effective in improving tic disorder symptoms, increasing treatment efficacy, and maintaining long-term benefits. However, due to the low quality of included RCTs and potential publication bias, further high-quality, large-sample, multicenter RCTs are needed for a more robust evaluation.

目的评价头皮针刺治疗抽动障碍的疗效和安全性。方法采用截至2023年5月16日的19项随机对照试验（RCTs）数据进行荟萃分析，涉及1463例患者，这些数据来自不同的数据库。采用Stata15.0评价临床有效率、YGTSS评分、中医证候评分、不良反应及远期疗效。结果头皮针刺组与对照组相比，YGTSS评分和中医证候评分显著降低，临床有效率显著提高[YGTSS: RR=-3.54, 95% CI (-5.16, -1.93), P < 0.05；中医:RR = -1.86, 95% CI (-2.60, -1.13), P & lt; 0.05;疗效：RR=1.14, 95% CI (1.06, 1.23), P < 0.05]。治疗组不良反应发生率较对照组低（7.29% vs 12.61%），但差异无统计学意义[OR=0.69, 95% CI (0.40, 1.18), P > 0.005]。长期疗效稳定[RR=-1.98, 95% CI (-3.57, -0.39), P < 0.05]。结论头皮针刺能有效改善抽动障碍症状，提高治疗效果，保持远期疗效。然而，由于纳入的随机对照试验的质量较低和潜在的发表偏倚，需要进一步的高质量、大样本、多中心随机对照试验来进行更稳健的评价。

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引用次数: 0

Masthead page 报头页面

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-01 DOI: 10.1016/S1550-8307(25)00141-7

引用次数: 0

Successful treatment of poliosis associated with vitiligo using unani medications: A case report. 使用unani药物成功治疗与白癜风相关的脊髓灰质炎：一例报告。

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-01 Epub Date: 2025-07-31 DOI: 10.1016/j.explore.2025.103230

Saba Ansari, Shaikh Mohammad Aatif Afzal, Mohd Arshad Jamal, Malik Itrat

Introduction: Poliosis, characterized by localized white hair patches due to the absence of melanin, often presents with vitiligo, a chronic depigmenting disorder. Conventional treatments show limited efficacy in managing poliosis, particularly when associated with vitiligo. This case report highlights a successful Unani treatment in a pediatric patient, demonstrating significant clinical improvement.

Case presentation: A 7-year-old female presented with a five-year history of a well-demarcated depigmented skin patch and white hair on the forehead. Following an unsuccessful course of allopathic treatment, the patient underwent Unani therapy comprising oral Zulal Safoofe Bars and topical Roghan (herbal oil). The oil was applied daily and followed by sun exposure.

Outcome: After two months, visible repigmentation of the skin and proximal hair shafts was observed. The patient tolerated the therapy well, and no adverse effects were reported.

Conclusion: This case suggests Unani therapy may be a promising, safe, and culturally acceptable alternative for treating poliosis associated with vitiligo. Further studies are needed to confirm its broader efficacy.

简介：小儿麻痹症的特点是由于缺乏黑色素导致局部发斑变白，通常表现为白癜风，一种慢性脱色障碍。传统治疗方法在治疗脊髓灰质炎方面疗效有限，特别是当与白癜风相关时。本病例报告强调了一名儿科患者成功的Unani治疗，显示出显著的临床改善。病例介绍：一名7岁女性，5年历史，有界限清晰的脱色皮肤斑块和额头上的白发。在对抗疗法疗程不成功后，患者接受了Unani疗法，包括口服Zulal Safoofe棒和局部Roghan（草药油）。这种油每天涂抹，然后日晒。结果：两个月后，观察到皮肤和近端毛干出现明显的色素沉着。患者对治疗耐受良好，无不良反应报告。结论：本病例提示Unani疗法可能是一种有希望的、安全的、文化上可接受的治疗白癜风相关脊髓灰质炎的替代疗法。需要进一步的研究来证实其更广泛的功效。

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引用次数: 0

Whole person symptom management: Adapting a palliative care approach across patient populations 全人症状管理：适应姑息治疗方法在病人群体

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-08-29 DOI: 10.1016/j.explore.2025.103244

Mary Koithan , Lisa Taylor-Swanson

引用次数: 0

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