Explore-The Journal of Science and Healing最新文献_第6页

Effect of inhalation of peppermint essential oil aromatherapy on postoperative delirium in old patients following major lower limb joint arthroplasty surgery: A randomized controlled trial 吸入薄荷精油芳香疗法对老年下肢大关节置换术后谵妄的影响：一项随机对照试验

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-11-01 DOI: 10.1016/j.explore.2025.103272

Mengyu Liu , Hai Tang , Zijian Zhou , Min Yang , Jinfeng Shen , Zhijie Ji , Maoyin Zhang

Background

Postoperative delirium (POD), a serious complication in elderly patients following major surgery, is strongly associated with increased morbidity and mortality. While peppermint essential oil (PEO) demonstrates cognitive-enhancing and neuroprotective properties, its efficacy in reducing POD incidence remains unclear. This study aims to evaluate the impact of inhaled PEO aromatherapy on POD incidence within 3 days after major lower limb arthroplasty (THA/TKA) in patients aged ≥65 years.

Methods

A total of 178 elderly patients scheduled for THA/TKA were randomized to either the PEO group (n = 89) or normal saline (NS) group (n = 89). The primary endpoint was POD incidence within 3 days postoperatively. Secondary endpoints included: delirium severity, duration, and subtype; pain scores at rest and during activity within postoperative 3 days; anxiety scores within 2 days post-surgery; adverse event incidence; neutrophil-to-lymphocyte ratio (NLR); and hospital length of stay.

Results

All 178 patients completed the trial (median age 70 years; 98 women [55.1 %]). The PEO group showed significantly lower POD incidence within 3 days postoperatively (7.9 % vs 19.1 %; risk ratio 0.412, 95 % confidence interval [CI] [0.179, 0.944], risk difference -0.112, 95 % CI [-0.215, -0.014], P = 0.048), with reduced pain scores (rest/activity) within the first 3 postoperative days and lower anxiety scores within the first 2 postoperative days (all P < 0.05) compared to the NS group.

Conclusion

Inhalation of PEO aromatherapy significantly reduces POD incidence within 3 days post-surgery and alleviates postoperative pain and anxiety in elderly patients undergoing major lower limb arthroplasty.

背景术后谵妄（POD）是老年患者大手术后的严重并发症，与发病率和死亡率的增加密切相关。虽然薄荷精油（PEO）显示出增强认知和神经保护的特性，但其在减少POD发病率方面的功效尚不清楚。本研究旨在评估吸入PEO芳香疗法对≥65岁患者大下肢关节置换术（THA/TKA）后3天内POD发生率的影响。方法178例计划行THA/TKA的老年患者随机分为PEO组（n = 89）和生理盐水组（n = 89）。主要终点是术后3天内POD的发生率。次要终点包括：谵妄严重程度、持续时间和亚型；术后3天内休息和活动时疼痛评分；术后2天内焦虑评分；不良事件发生率；中性粒细胞与淋巴细胞比值（NLR）；还有住院时间。结果178例患者全部完成试验（中位年龄70岁，女性98例，占55.1%）。PEO组术后3天内POD发生率明显低于NS组（7.9% vs 19.1%；风险比0.412,95%可信区间[CI][0.179, 0.944]，风险差-0.112,95% CI [-0.215, -0.014], P = 0.048），术后前3天疼痛评分（休息/活动）降低，术后前2天焦虑评分降低（均P <； 0.05）。结论吸入PEO芳香疗法可显著降低老年下肢大关节置换术患者术后3 d内POD的发生率，减轻术后疼痛和焦虑。

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引用次数: 0

Translational reinterpretation of ancestral healing rituals: Structured physiological modulation through adaptive biological responses 祖先治疗仪式的翻译重新解释：通过适应性生物反应的结构化生理调节。

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-11-01 DOI: 10.1016/j.explore.2025.103274

João Francisco Pollo Gaspary , Alfred Lee Edgar , Fernanda Peron Gaspary , Eduarda Grando Lopes , Luis Felipe Dias Lopes

Background

Ancestral healing rituals have long been embedded in cultural traditions as symbolic practices. However, emerging evidence suggests these rituals may act as structured behavioral interventions capable of eliciting adaptive physiological responses. This study proposes a translational reinterpretation of ancestral healing rituals through the lens of contemporary redox biology, systems physiology, and bioenergetic modulation.

Methods

Using a Work Breakdown Structure (WBS) and PRISMA-guided systematic reviews, the study was organized into five work packages (WP’s). Historical (WP2) and physiological (WP3) systematic reviews identified Fundamental Points of View (FPV’s) and Critical Success Factors (CSF’s). Heuristic triangulation in WP4 led to the emergence of the APEIC model (Adaptive Psychoneuroendocrineimmunometabolic Cascade), integrating behavioral practices with bioenergetic and metabolic processes. The model was validated in WP5 using SMART and FINER criteria.

Results

Five FPV’s (e.g., meditation, fasting, ritual celebration) and thirteen CSFs (e.g., redox modulation, neuroplasticity, immune adaptation) were identified. Findings suggest that rituals rhythmically modulate proton gradients, redox balance, and metabolic flexibility, contributing to systemic coherence. The APEIC model explains how ritual-induced stimuli can synchronize psychoneuroendocrine, immune, and metabolic systems via transient physiological oscillations. Endogenous DMT is proposed as a potential biomarker of integrative coherence.

Conclusion

Ancestral healing rituals can be reinterpreted as biologically plausible platforms for inducing adaptive physiological states. The APEIC model provides a conceptual foundation for non-pharmacological health strategies rooted in ancestral behavioral intelligence. Future studies should experimentally test the model’s mechanisms to inform integrative and personalized healthcare applications.

背景：祖先的治疗仪式长期以来一直作为象征性的实践嵌入文化传统中。然而，新出现的证据表明，这些仪式可能是一种结构化的行为干预，能够引发适应性的生理反应。本研究通过当代氧化还原生物学、系统生理学和生物能量调节的视角，提出了对祖先治疗仪式的翻译重新解释。方法：采用工作分解结构（WBS）和prisma引导的系统评价，将研究组织为五个工作包（WP’s）。历史（WP2）和生理（WP3）系统评价确定了基本观点（FPV）和关键成功因素（CSF）。WP4中的启发式三角测量导致了APEIC模型（适应性心理神经内分泌免疫代谢级联）的出现，将行为实践与生物能量和代谢过程结合起来。采用SMART和FINER标准在WP5中对模型进行验证。结果：鉴定出5种FPV（如冥想、禁食、仪式庆祝）和13种csf（如氧化还原调节、神经可塑性、免疫适应）。研究结果表明，仪式有节奏地调节质子梯度、氧化还原平衡和代谢灵活性，有助于系统一致性。APEIC模型解释了仪式诱导的刺激如何通过短暂的生理振荡使心理神经内分泌、免疫和代谢系统同步。内源性DMT被认为是整合一致性的潜在生物标志物。结论：祖先的治疗仪式可以被重新解释为诱导适应性生理状态的生物学可信平台。APEIC模型为植根于祖先行为智力的非药物健康策略提供了概念基础。未来的研究应该通过实验测试该模型的机制，为综合和个性化医疗保健应用提供信息。

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引用次数: 0

An interpretative phenomenological inquiry into older adults’ experience of nature through virtual reality and its effect on their perceived well-being 通过虚拟现实对老年人自然体验的解释性现象学探究及其对他们感知幸福感的影响。

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-11-01 DOI: 10.1016/j.explore.2025.103273

Ave Kotze , Tony Ward , Erinma Ochu

Objectives

To explore older adults’ lived experiences of nature through immersive virtual reality (VR) and its influence on their perceived well-being in care home settings.

Methods

Using Interpretative Phenomenological Analysis (IPA), eight older adults (aged 85–98) residing in care homes engaged with 360-degree VR videos of natural environments. Data were collected via VR-assisted interviews and follow-up semi-structured interviews.

Results

Participants reported a broad spectrum of complex emotional responses, ranging from relaxation and reminiscence to sadness and disconnection. Key experiential themes included immersion and escapism, emotional evocation, and reflections on limitations and loss.

Discussion

The study reveals that virtual nature experiences can evoke emotionally complex responses, underscoring the need for individualised and context-sensitive implementation. It cautions against overstating VR’s positive effects and calls for trauma-informed, age-appropriate approaches that take account of personal history and technological limitations. By openly reporting less favourable experiences, this study contributes to a more balanced evidence base and challenges prevailing publication bias in VR research.

目的：通过沉浸式虚拟现实（VR）探索老年人的自然生活体验及其对他们在养老院环境中的感知幸福感的影响。方法：采用解释性现象学分析（IPA）方法，对8名居住在养老院的85-98岁老年人进行360度自然环境VR视频研究。通过虚拟现实辅助访谈和后续半结构化访谈收集数据。结果：参与者报告了广泛的复杂情绪反应，从放松和回忆到悲伤和脱节。关键的体验主题包括沉浸和逃避，情感唤起，以及对限制和损失的反思。讨论：该研究揭示了虚拟自然体验可以唤起情感上的复杂反应，强调了个性化和上下文敏感实施的必要性。它告诫人们不要夸大虚拟现实的积极影响，并呼吁采用考虑个人历史和技术限制的创伤知情、适合年龄的方法。通过公开报告不太有利的经验，本研究有助于建立更平衡的证据基础，并挑战VR研究中普遍存在的出版偏见。

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引用次数: 0

Compassion, connection, and capacity: Outcomes of a yearlong contemplative medicine fellowship 同情，联系和能力：为期一年的冥想医学奖学金的结果

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-10-24 DOI: 10.1016/j.explore.2025.103269

Anne Kennard , Jennifer Clinkenbeard , Erin Gillespie , David Iozzi

Objective

To evaluate how a year-long Contemplative Medicine Fellowship impacts physician burnout, moral injury, work-life integration, meaning, capacity for compassion, and professional resilience.

Design

A pre–post survey observational study using a combination of validated survey tools and questionnaire items authored by the research team.

Setting

The New York Zen Center for Contemplative Care (NYZC), an educational nonprofit in the US, offers a year-long, remote learning fellowship in contemplative medicine that integrates mindfulness, compassion training, reflective inquiry, community engagement, and other contemplative approaches to the practice of medicine.

Intervention

Participation in the Contemplative Medicine Fellowship, which includes experiential contemplative practice, didactic instruction, mentorship, peer-group reflection, and cultivation of a community of support over 12 months.

Main outcome measures

Primary outcomes included changes in burnout, well-being, and compassion (Maslach Burnout Inventory, Physician Well-Being Index, DPES-Compassion Scale).

Participant’s perceived value of the intervention is also assessed.

Results

Participants showed statistically significant reductions in emotional exhaustion (–10.0 points, P < .001) and depersonalization (–3 points, P = .015); increases in measures related to well-being; and statistically significant increases in compassion (+0.4 points, P = .022). Participants also reported a high level of satisfaction with the intervention and an increased sense of community.

Conclusions

Contemplative training may mitigate burnout and moral distress while fostering compassion, meaning, connection, and leadership in clinical practice. Future endeavors may consider more widespread education and implementation of these concepts into medical education and practice as part of a cultural shift of medicine towards sustainable clinician well-being.

目的评价为期一年的冥想医学奖学金对医生职业倦怠、道德伤害、工作-生活融合、意义、同情能力和职业弹性的影响。设计一项调查前后的观察性研究，使用经过验证的调查工具和由研究小组撰写的问卷项目相结合。纽约禅宗禅修中心（NYZC）是美国一家非营利教育机构，提供为期一年的禅修医学远程学习奖学金，将正念、同情训练、反思探究、社区参与和其他禅修方法整合到医学实践中。干预：参加冥想医学奖学金，包括为期12个月的体验冥想练习、教学指导、指导、同伴小组反思和社区支持的培养。主要结果测量：主要结果包括倦怠、幸福感和同情心的变化（Maslach倦怠量表、医生幸福感指数、dpes -同情心量表）。参与者对干预的感知价值也被评估。结果受试者情绪耗竭（-10.0分，P < 0.001）、人格解体（-3分，P = 0.015）显著降低；增加与福祉有关的措施；并且在统计上显著增加了同情心（+0.4点，P = 0.022）。参与者还报告了对干预的高度满意度和社区意识的增强。结论：在临床实践中，冥想训练可以减轻倦怠和道德困扰，同时培养同情心、意义、联系和领导能力。未来的努力可能会考虑将这些概念更广泛地教育和实施到医学教育和实践中，作为医学文化向可持续临床医生福祉转变的一部分。

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引用次数: 0

Osteopathic manipulative treatment improves mobility restrictions and statics in a patient with a pectus excavatum after a sternochondroplasty. A case report 整骨疗法的手法治疗改善了胸骨软骨成形术后漏斗胸患者的活动受限和静止性。病例报告

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-10-17 DOI: 10.1016/j.explore.2025.103270

Kelly Jeandey , Aymerick Le Nohaïc , Laurence Solovei , Géraud Gourjon

Context

Pectus excavatum (PE) is characterized by abnormal development of the sternum and costal cartilages resulting in a posterior depression of the rib cage. Sternochondroplasty is a surgical technique used to correct severe PE and restore anatomical and functional integrity. However, post-operative musculoskeletal disorders may persist. To date, the potential of osteopathic manipulative treatment (OMT) after sternochondroplasty has not been investigated.

Case description

A 23-year-old female presented with musculoskeletal pain, reduced mobility, and persistent chest paresthesias following corrective surgery for severe PE.

Intervention and outcomes

The patient underwent OMT over the course of one year (18 sessions). Posture, stabilometric parameters, respiratory function, and somatic dysfunctions were assessed during this period.

Clinical outcomes included improvements in mobility, posture (4° in the sagittal plane and 3° in the frontal plane), reduction of somatic dysfunctions (from 41 to 4), and decreased pain. Respiratory reassessment also demonstrated significant improvements (VO2max increased from 16 to 22.2mL/kg.min (+38 %)).

Conclusion

This case highlights the potential clinical benefits of OMT as an adjunct to usual postoperative care in the recovery from sternochondroplasty. Further research is warranted to confirm these findings.

挖掘胸肌（PE）的特点是胸骨和肋软骨发育异常，导致胸腔后凹陷。胸骨软骨成形术是一种用于纠正严重PE并恢复解剖和功能完整性的手术技术。然而，术后肌肉骨骼疾病可能持续存在。迄今为止，尚未对胸骨软骨成形术后的骨科手法治疗（OMT）的潜力进行研究。病例描述：一名23岁女性，在接受严重PE矫正手术后，表现为肌肉骨骼疼痛、活动能力降低和持续的胸部感觉异常。干预和结果患者接受了为期一年（18次）的OMT治疗。在此期间评估姿势、稳定参数、呼吸功能和躯体功能障碍。临床结果包括活动能力和姿势的改善（矢状面4°和额平面3°），躯体功能障碍的减少（从41°降至4°）和疼痛的减轻。呼吸重评估也显示出显著的改善（VO2max从16 ml /kg增加到22.2mL/kg）。最小（+ 38%）)。结论本病例强调了OMT作为常规胸骨软骨成形术术后康复辅助治疗的潜在临床益处。需要进一步的研究来证实这些发现。

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引用次数: 0

Bridging the gap: Methodological refinements to clarify the role of acupressure in the management of preoperative anxiety 弥合差距：方法学上的改进，以澄清穴位按压在术前焦虑管理中的作用。

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-10-13 DOI: 10.1016/j.explore.2025.103267

Fei-Yi Zhao , Wen-Jing Zhang , Ting Jiang , Qiang-Qiang Fu

引用次数: 0

Reinterpreting the code: A resonance loop model for destigmatizing the mind 重新解释代码：一个共振回路模型去污名化的思想

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-10-10 DOI: 10.1016/j.explore.2025.103268

Doha Lee

Conventional psychiatric frameworks often reduce mental disorders to neurochemical imbalances or structural abnormalities. While informative, such reductionist models may overlook the dynamic interplay among perception, emotion, memory, and cognition—and may inadvertently reinforce stigma. Here, we propose that mental symptoms can instead be understood as emergent states of phase incoherence within interconnected bioelectromagnetic resonance loops that span multiple sensory, affective, and regulatory domains. These loops are proposed to integrate sensory input, cardiovascular-affective feedback, emotional encoding, memory retrieval, and cognitive control, such that distinct mental states may reflect specific forms of phase misalignment across these systems. For example, autism spectrum conditions may involve hypercoherence in sensory pathways alongside desynchronized regulatory modulation, while schizophrenia may reflect resonance interference between trauma-encoded memory and emotional processing loops. Likewise, panic and dissociative states may arise from transient maladaptive realignments across these networks. Rather than viewing such conditions as fixed impairments, this model conceptualizes them as dynamic, temporarily adaptive configurations of a nonlinear sensory system. On this basis, it opens the door to non-pharmacological interventions—such as heart-rate-variability (HRV) feedback, frequency-based loop modulation, and environmental resonance tuning—and supports a neuroecological perspective on mental diversity. To clarify its scope, we also propose several testable predictions. Specifically, mental symptom severity may correlate with phase incoherence across loop-synchronized EEG-HRV signals; targeted frequency stimulation could induce measurable resonance realignment in specific mental states; individuals with dissociative tendencies may show greater instability in cross-loop phase synchrony during memory recall; and loop-coherence interventions might reduce symptom intensity without pharmacological input. Taken together, this Model aims to foster both theoretical advancement and stigma reduction by reframing mental phenomena as resonance-based adaptations rather than structural deficits.

传统的精神病学框架通常将精神障碍归结为神经化学失衡或结构异常。虽然信息丰富，但这种还原论模型可能忽略了感知、情感、记忆和认知之间的动态相互作用，并且可能无意中强化了耻辱感。在这里，我们提出精神症状可以被理解为在跨越多个感觉、情感和调节领域的相互关联的生物电磁共振回路中相不相干的涌现状态。这些回路被认为整合了感觉输入、心血管-情感反馈、情绪编码、记忆检索和认知控制，因此不同的精神状态可能反映了这些系统中特定形式的相位失调。例如，自闭症谱系条件可能涉及感觉通路的超相干性以及不同步的调节调节，而精神分裂症可能反映创伤编码记忆和情绪处理回路之间的共振干扰。同样，恐慌和分离状态可能是由这些网络的短暂不适应重新调整引起的。该模型不是将这些条件视为固定的缺陷，而是将它们概念化为非线性感觉系统的动态、临时自适应配置。在此基础上，它打开了非药物干预的大门，如心率变异性（HRV）反馈、基于频率的环路调制和环境共振调谐，并支持了心理多样性的神经生态学观点。为了澄清其范围，我们还提出了几个可测试的预测。具体而言，精神症状的严重程度可能与环同步脑电图- hrv信号的相位不相干相关；有针对性的频率刺激可以在特定的精神状态下诱发可测量的共振重组；具有分离倾向的个体在回忆过程中表现出更大的交叉环路同步不稳定性；环路一致性干预可能在没有药物投入的情况下减少症状强度。综上所述，该模型旨在通过将心理现象重新定义为基于共振的适应而不是结构性缺陷来促进理论进步和减少耻辱感。

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引用次数: 0

Efficacy of a traditional persian fruit infusion (Naqu Fawakeh) versus silymarin in reducing chemotherapy-induced hepatotoxicity in pediatric ALL: A triple-blind randomized clinical trial 传统波斯果输注（Naqu Fawakeh）与水飞蓟素降低儿科ALL化疗引起的肝毒性的疗效：一项三盲随机临床试验

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-26 DOI: 10.1016/j.explore.2025.103265

Fariba Ettehadi , Omid Reza Zekavat , Ali Tavakkoli , Foroogh Namjoyan , Mehrab Sayadi , Yasaman Vazani

Maintenance-phase Chemotherapy-induced hepatotoxicity is concerned in pediatric Acute Lymphoblastic Leukemia (ALL). Traditional Persian Medicine (TPM) recommends Naqu Fawakeh, a fruit-based infusion, for liver inflammation. This study compare the effect of Naqu Fawakeh and silymarin on Chemotherapy side effects.

In this triple-blind, randomized clinical trial, 82 children aged 5–17 years received either Naqu Fawakeh (n = 44) or silymarin (n = 38) for eight weeks. Both groups were administered by 5 mL (<30 kg body weight) and 10 mL (≥30 kg), three times daily after meals. Liver enzymes (AST, ALT) and chemotherapy-related symptoms (nausea, vomiting, constipation, thirst) were assessed before and after the intervention. No placebo group was included due to ethical considerations.

Both interventions significantly reduced liver enzyme levels, with a greater effect in the Naqu Fawakeh group. The mean difference between groups was significant for ALT (P = 0.029). ALT decreased significantly in the Naqu Fawakeh group (P < 0.001) and in the silymarin group (P = 0.005); AST also decreased in both groups (Naqu Fawakeh: P = 0.005; silymarin: P = 0.011). Both treatments reduced nausea and vomiting within and after 24 h, as well as thirst, though the between-group mean difference was significant only for thirst (P = 0.001). Reductions in nausea and thirst were consistently greater in the Naqu Fawakeh group. No adverse renal or hematologic effects were observed.

Therfore Naqu Fawakeh, as a safe and supportive therapy, is more effective than silymarin in reducing liver enzyme. Further studies are confirmed findings.

维持期化疗引起的肝毒性是儿童急性淋巴细胞白血病（ALL）的关注。传统波斯医学（TPM）推荐Naqu Fawakeh，一种以水果为基础的输液，用于治疗肝脏炎症。本研究比较了那曲法克和水飞蓟素对化疗副作用的影响。在这项三盲随机临床试验中，82名5-17岁的儿童接受了8周的Naqu Fawakeh （n = 44）或水飞蓟素（n = 38）治疗。两组患者分别用5 mL（≤30 kg体重）和10 mL（≥30 kg体重）给药，每日3次，饭后给药。在干预前后评估肝酶（AST、ALT）和化疗相关症状（恶心、呕吐、便秘、口渴）。出于伦理考虑，没有纳入安慰剂组。两种干预措施都显著降低了肝酶水平，Naqu Fawakeh组的效果更大。ALT组间平均差异有统计学意义（P = 0.029）。Naqu Fawakeh组（P < 0.001）和水飞蓟素组（P = 0.005） ALT显著降低；两组AST也均降低（Naqu Fawakeh: P = 0.005；水飞蓟素：P = 0.011）。两种治疗方法均减少了24小时内和24小时后的恶心和呕吐，以及口渴，但组间平均差异仅在口渴方面具有统计学意义（P = 0.001）。在Naqu Fawakeh组中，恶心和口渴的减轻程度一直更大。没有观察到不良的肾脏或血液反应。因此，那曲法克作为一种安全的支持性治疗，在降低肝酶方面比水飞蓟素更有效。进一步的研究证实了这一发现。

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引用次数: 0

The effect of acupressure on polyneuropathy-related pain and sleep quality in patients with type 2 diabetes: A randomised controlled trial 穴位按压对2型糖尿病患者多神经病相关疼痛和睡眠质量的影响：一项随机对照试验

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-19 DOI: 10.1016/j.explore.2025.103262

Fatma Gündüz-Oruç , Elanur Yilmaz-Karabulutlu

Aim

This study aimed to determine the effect of acupressure on polyneuropathy-related pain and sleep quality in patients with type 2 diabetes.

Design

A randomized controlled experimental design was employed in the study.

Methods

The study sample consisted of 86 patients with type 2 diabetes (44 in the acupressure group and 42 in the control group) who met the inclusion criteria and agreed to participate. Participants were randomly assigned to either the experimental or control group. The experimental group received six sessions of acupressure over six consecutive days, while the control group received no intervention. Data were collected using a personal information form, the Pain Quality Assessment Scale (PQAS), and the Pittsburgh Sleep Quality Index (PSQI). Statistical analyses were conducted using SPSS for Windows 22.

Results

In the acupressure group, post-test mean scores of the PQAS subscales—Paroxysmal Pain (t=-8.636; p<0.001), Surface Pain (t=-7.649; p<0.001), and Deep Pain (t=-10.349; p<0.001)—significantly decreased compared to the control group. Additionally, the acupressure group demonstrated a significant improvement in post-test PSQI total scores (U=70.000; p<0.001) and sleep quality subscale scores compared to the control group, except for the Sleep Medication Use subscale (U=831.000; p=0.149), which showed no significant difference.

Conclusions

Acupressure was found to reduce polyneuropathy-related pain and enhance sleep quality in patients with type 2 diabetes. Therefore, acupressure may be considered an alternative nursing intervention for individuals with type 2 diabetes.

目的探讨穴位按压对2型糖尿病患者多神经病变相关疼痛及睡眠质量的影响。设计本研究采用随机对照实验设计。方法选取符合入选标准并同意参与研究的2型糖尿病患者86例（穴位按压组44例，对照组42例）。参与者被随机分为实验组和对照组。实验组连续6天进行6次穴位按压，对照组不进行干预。使用个人信息表、疼痛质量评估量表（PQAS）和匹兹堡睡眠质量指数（PSQI）收集数据。采用SPSS for Windows 22进行统计分析。结果穴位按压组PQAS亚量表-阵发性疼痛（t=-8.636; p<0.001）、体表疼痛（t=-7.649; p<0.001）和深度疼痛（t=-10.349; p<0.001）的测试后平均评分较对照组显著降低。此外，与对照组相比，穴位按压组在测试后PSQI总分（U=70.000; p<0.001）和睡眠质量量表得分均有显著改善，但睡眠药物使用量表（U=831.000; p=0.149）差异无统计学意义。结论穴位按压可减轻2型糖尿病患者多神经病变相关疼痛，提高睡眠质量。因此，穴位按压可以被认为是2型糖尿病患者的一种替代护理干预。

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引用次数: 0

Effects on plasma oxytocin and dopamine levels through a five-minute audiovisual stimulus of Greek Syrtaki: An intervention-control primary care study 通过5分钟希腊sytaki视听刺激对血浆催产素和多巴胺水平的影响：一项干预控制初级保健研究

IF 2.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing

Pub Date : 2025-09-19 DOI: 10.1016/j.explore.2025.103263

Panagiotis Volkos , Panagiotis Stachteas , Manolis Linardakis , Evangelia Skouradaki , Stavroula Baritaki , Sirja Koutonen , Niki Malliaraki , Marilena Kampa , Emmanouil K Symvoulakis

Background

Culturally familiar or preferred music has been found to impact levels of neurotransmitters and hormones. The study aimed to explore the potential influence of an audiovisual stimulus, featuring Greek Syrtaki music, on plasma oxytocin and dopamine levels among primary care attendees and the associations between their variations, socio-demographic factors, and baseline levels of loneliness.

Methods

Eighty primary care attendees participated in the study (40 in the intervention group and 40 in the control group). Early morning blood sample collection took place between December 2023 and June 2024. Commercial ELISA kits from Abcam (Cambridge, UK) were used to measure oxytocin and dopamine levels. Syrtaki music by M. Theodorakis was provided in audiovisual format. The University of California, Los Angeles Loneliness Scale (Version 3) was used and correlated with oxytocin and dopamine levels.

Results

Post-intervention oxytocin levels increased on average by 0.72 pg/ml (p < 0.001) in 85.0 % of intervention group participants, while dopamine levels increased by 0.21 ng/ml (p = 0.001) in 67.5 % of intervention group participants. Multiple logistic regression analysis showed that, for each unit increase in the loneliness scale, the odds of post-intervention elevated oxytocin and dopamine levels significantly decreased (OR=0.88, p = 0.039).

Conclusion

Decoding hormonal response to a well-known culturally based music element and its associations with baseline loneliness offers new knowledge on the interrelation between proactive behaviors of bonding, social connection, and personal well-being.

研究发现，文化上熟悉或喜欢的音乐会影响神经递质和激素的水平。该研究旨在探索以希腊Syrtaki音乐为特色的视听刺激对初级保健参与者血浆催产素和多巴胺水平的潜在影响，以及它们的变化、社会人口因素和基线孤独水平之间的关联。方法80例初级保健患者参加本研究，其中干预组40例，对照组40例。在2023年12月至2024年6月期间进行了清晨血液样本采集。使用Abcam （Cambridge， UK）的商用ELISA试剂盒检测催产素和多巴胺水平。由M. Theodorakis创作的sytaki音乐以视听形式提供。使用加州大学洛杉矶分校孤独量表（版本3），并将其与催产素和多巴胺水平相关联。结果干预组85.0%的受试者干预后催产素水平平均升高0.72 pg/ml (p < 0.001)，干预组67.5%的受试者干预后多巴胺水平平均升高0.21 ng/ml （p = 0.001）。多元logistic回归分析显示，孤独感量表每增加一个单位，干预后催产素和多巴胺水平升高的几率显著降低（OR=0.88, p = 0.039）。破译激素对一种众所周知的基于文化的音乐元素的反应及其与基线孤独感的关联，为联系、社会联系和个人幸福感的主动行为之间的相互关系提供了新的知识。

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