Medical Image Restoration (MIR) represents a classic yet challenging task in computer vision and image processing, aiming to reconstruct High-Quality (HQ) medical images from their Low-Quality (LQ) counterparts degraded by factors such as low-dose acquisition, limited resolution, or modality-specific noise. The diversity of degradation types complicates the design of MIR models that can be applied across different modalities and restoration tasks. However, existing MIR approaches mainly focus on designing specialized network architectures with limited ability to generalize across multiple MIR scenarios. To address this issue, we first analyze diverse medical image degradations from a unified frequency-domain perspective. Building on this insight, we propose the Hybrid-Domain Fusion Network (HDFNet), an efficient hybrid-domain framework that integrates spatial and frequency priors for CT and MRI restoration. Specifically, the proposed HDFNet adopts a dual-domain hybrid structure that performs multi-scale receptive field modeling in both spatial and frequency domains: the spatial domain preserves local anatomical structures, while the frequency domain enhances global consistency and suppresses artifacts via Fast Fourier Transform (FFT)-based operations. In particular, we introduce frequency-aware Harmonic Positional Encoding (HPE) and Frequency Adaptive Convolution (FAC) to extract rich semantic frequency features tailored to different degradation types. Extensive experiments on Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) restoration tasks demonstrate that the proposed HDFNet provides a robust and efficient solution for CT and MRI restoration, and shows promising generalization to broader MIR tasks.
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