Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181CB47DA
R. Luboshitzky, A. Ishay, P. Herer
It is not clear whether or not subclinical hypothyroidism (SH) is associated with an increased risk for cardiovascular disease. We prospectively examined 43 women with SH and 49 healthy controls of similar age. Fasting blood levels of thyrotropin, free thyroxin, antibodies to thyroid peroxidase and thyroglobulin, glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and insulin were measured. Body mass index, waist and hip circumferences, blood pressure, homeostasis model assessment 2-insulin resistance index, and the presence of metabolic syndrome (MS) were also evaluated. Mean systolic blood pressure was increased in SH patients versus controls (128.6 vs. 120.7 mm Hg; P 0.04). Mean values of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and insulin were not different in patients with SH compared with controls. SH had significantly higher triglyceride levels (1.50 0.65 mmol/L) and glucose levels (5.26 0.63 mmol/L) compared with controls (1.27 0.59, 5.05 0.52; P 0.04, P 0.04, respectively). Although body mass index values were similar in both groups, patients had greater waist circumference than controls (90.7 13 cm vs. 81.8 10.6; P 0.0007). The percentages of patients with SH having hypertension (34.1%), hypertriglyceridemia (37.2%), hyperglycemia (20.9%), and greater waist circumference (51.2%) were higher than the percentages in controls. Thus, the percentage of MS in patients (41.5%) was significantly higher than in controls (12.2%; P 0.003). SH had significantly higher likelihood of cardiovascular risks (odds ratio, 6.26; 95% confidence interval, 1.6–4.49; P 0.008 for MS). We conclude that SH is associated with greater probability of MS. This may increase the risk of accelerated atherosclerosis and premature cardiovascular disease in these patients.
目前尚不清楚亚临床甲状腺功能减退症(SH)是否与心血管疾病风险增加有关。我们前瞻性地检查了43名SH女性和49名年龄相仿的健康对照。测定空腹血促甲状腺素、游离甲状腺素、甲状腺过氧化物酶抗体和甲状腺球蛋白、葡萄糖、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯和胰岛素水平。还评估了体重指数、腰围和臀围、血压、稳态模型评估2-胰岛素抵抗指数和代谢综合征(MS)的存在。与对照组相比，SH患者的平均收缩压升高(128.6 vs. 120.7 mm Hg;P 0.04)。SH患者的总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和胰岛素的平均值与对照组相比没有差异。SH组甘油三酯水平(1.50 0.65 mmol/L)和葡萄糖水平(5.26 0.63 mmol/L)显著高于对照组(1.27 0.59,5.05 0.52;P < 0.04, P < 0.04)。尽管两组的体重指数相似，但患者的腰围大于对照组(90.7 13 cm vs 81.8 10.6 cm;P 0.0007)。SH患者合并高血压(34.1%)、高甘油三酯血症(37.2%)、高血糖(20.9%)和大腰围(51.2%)的比例高于对照组。因此，患者中MS的比例(41.5%)显著高于对照组(12.2%;P 0.003)。SH有更高的心血管风险可能性(优势比，6.26;95%置信区间为1.6-4.49;MS为P 0.008)。我们得出的结论是，SH与ms的可能性较大相关，这可能会增加这些患者加速动脉粥样硬化和过早心血管疾病的风险。
{"title":"Metabolic Syndrome and Insulin Resistance in Women With Subclinical Hypothyroidism","authors":"R. Luboshitzky, A. Ishay, P. Herer","doi":"10.1097/TEN.0B013E3181CB47DA","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181CB47DA","url":null,"abstract":"It is not clear whether or not subclinical hypothyroidism (SH) is associated with an increased risk for cardiovascular disease. We prospectively examined 43 women with SH and 49 healthy controls of similar age. Fasting blood levels of thyrotropin, free thyroxin, antibodies to thyroid peroxidase and thyroglobulin, glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and insulin were measured. Body mass index, waist and hip circumferences, blood pressure, homeostasis model assessment 2-insulin resistance index, and the presence of metabolic syndrome (MS) were also evaluated. Mean systolic blood pressure was increased in SH patients versus controls (128.6 vs. 120.7 mm Hg; P 0.04). Mean values of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and insulin were not different in patients with SH compared with controls. SH had significantly higher triglyceride levels (1.50 0.65 mmol/L) and glucose levels (5.26 0.63 mmol/L) compared with controls (1.27 0.59, 5.05 0.52; P 0.04, P 0.04, respectively). Although body mass index values were similar in both groups, patients had greater waist circumference than controls (90.7 13 cm vs. 81.8 10.6; P 0.0007). The percentages of patients with SH having hypertension (34.1%), hypertriglyceridemia (37.2%), hyperglycemia (20.9%), and greater waist circumference (51.2%) were higher than the percentages in controls. Thus, the percentage of MS in patients (41.5%) was significantly higher than in controls (12.2%; P 0.003). SH had significantly higher likelihood of cardiovascular risks (odds ratio, 6.26; 95% confidence interval, 1.6–4.49; P 0.008 for MS). We conclude that SH is associated with greater probability of MS. This may increase the risk of accelerated atherosclerosis and premature cardiovascular disease in these patients.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"71 1","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74818977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/ten.0b013e3181c9f58d
H. K. Goh, Michael Chia, Y. Ooi, D. Chew
Abstract:Hypoglycemia can occur as a complication during the treatment of diabetes mellitus. The potential neurologic consequences of severe hypoglycemia, including coma and seizure, are well-recognized. Less commonly considered are possible cardiovascular complications associated with hypoglycemia.
{"title":"Silent Myocardial Infarction and Hypoglycaemia: Four Case Reports and a Discussion on Causality","authors":"H. K. Goh, Michael Chia, Y. Ooi, D. Chew","doi":"10.1097/ten.0b013e3181c9f58d","DOIUrl":"https://doi.org/10.1097/ten.0b013e3181c9f58d","url":null,"abstract":"Abstract:Hypoglycemia can occur as a complication during the treatment of diabetes mellitus. The potential neurologic consequences of severe hypoglycemia, including coma and seizure, are well-recognized. Less commonly considered are possible cardiovascular complications associated with hypoglycemia.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"4 1","pages":"2-6"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84376870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181CB47C6
D. Dhanwal, N. Tandon, R. Tandon, S. Chumber, A. Ammini
{"title":"Multiple Endocrine Neoplasia (MEN) Syndrome2B With Ectopic Cushing Syndrome","authors":"D. Dhanwal, N. Tandon, R. Tandon, S. Chumber, A. Ammini","doi":"10.1097/TEN.0B013E3181CB47C6","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181CB47C6","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84732244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181CA0FC0
P. Heras, K. Kritikos, A. Hatzopoulos, N. Kritikos, D. Mitsibounas
{"title":"Psychological Consequences of Obesity","authors":"P. Heras, K. Kritikos, A. Hatzopoulos, N. Kritikos, D. Mitsibounas","doi":"10.1097/TEN.0B013E3181CA0FC0","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181CA0FC0","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"1 1","pages":"27-28"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79655904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181C9FE34
F. Pitoia, R. Chervin, S. Nuñez, M. Salvai, E. Tamer, D. Schere, H. Nièpomniszcze
Objective:Following radioiodine (RI) therapy for multinodular goiter (MNG), 4% to 5% of patients are reported to develop Graves' hyperthyroidism. To show a new protocol for the administration of RI in MNG and to illustrate an infrequent adverse event observed after the RI dose.Methods:A 70-year-old
{"title":"Development of Graves' Disease Following a Radioiodine Dose for the Shrinkage of a Multinodular Goiter After Using a Novel Protocol","authors":"F. Pitoia, R. Chervin, S. Nuñez, M. Salvai, E. Tamer, D. Schere, H. Nièpomniszcze","doi":"10.1097/TEN.0B013E3181C9FE34","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181C9FE34","url":null,"abstract":"Objective:Following radioiodine (RI) therapy for multinodular goiter (MNG), 4% to 5% of patients are reported to develop Graves' hyperthyroidism. To show a new protocol for the administration of RI in MNG and to illustrate an infrequent adverse event observed after the RI dose.Methods:A 70-year-old","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"32 1","pages":"7-9"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91253635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181CB480F
I. Anaforoglu, E. Algün, R. Sahin, İsmail Hakk Ocak
{"title":"Sestamibi Retention in a Breast Fibroadenoma in a Case of Hypercalcemia With Parathyroid Adenoma","authors":"I. Anaforoglu, E. Algün, R. Sahin, İsmail Hakk Ocak","doi":"10.1097/TEN.0B013E3181CB480F","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181CB480F","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"1 1","pages":"17-18"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77582671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181C9F2C0
Z. Sağlam, T. Saler, T. Erdem, E. Ataoğlu, Levent Umit Temiz, M. Yenigun
Objectives:In order to ascertain the impact of diabetes and diabetic complications on the risk of depression in the Turkish population, the Beck Depression Inventory (BDI) was used to investigate the frequency of depression in type 1 and type 2 diabetes mellitus patients (T1DM and T2DM) compared to
{"title":"The Frequency of Depression in Turkish Patients With Diabetes and Diabetic Complications","authors":"Z. Sağlam, T. Saler, T. Erdem, E. Ataoğlu, Levent Umit Temiz, M. Yenigun","doi":"10.1097/TEN.0B013E3181C9F2C0","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181C9F2C0","url":null,"abstract":"Objectives:In order to ascertain the impact of diabetes and diabetic complications on the risk of depression in the Turkish population, the Beck Depression Inventory (BDI) was used to investigate the frequency of depression in type 1 and type 2 diabetes mellitus patients (T1DM and T2DM) compared to","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"51 1","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89609876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181C8CAF9
Y. Bee, L. P. Chan, C. Goh
{"title":"A Man With Persistent, Enigmatic Bone Pain and Hypophosphatemia","authors":"Y. Bee, L. P. Chan, C. Goh","doi":"10.1097/TEN.0B013E3181C8CAF9","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181C8CAF9","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"29 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87213518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-01-01DOI: 10.1097/TEN.0B013E3181CA0410
M. Çıkrıkçıoğlu, I. Elik, M. Hurşitoğlu, H. Erkal, Mustafa Çakırca, Tülin Kurt, G. Alıcı, T. Tükek
{"title":"The Prevalence of Low T3 With Arrhythmia and Heart Failure in Patients With Acute Coronary Syndrome","authors":"M. Çıkrıkçıoğlu, I. Elik, M. Hurşitoğlu, H. Erkal, Mustafa Çakırca, Tülin Kurt, G. Alıcı, T. Tükek","doi":"10.1097/TEN.0B013E3181CA0410","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181CA0410","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"60 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85759761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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