Pub Date : 2010-07-01DOI: 10.1097/TEN.0B013E3181E94730
A. Hubalewska-Dydejczyk, W. Nowak, A. Matyja, A. Kasperlik-Załuska, Marie Kmita, J. Gil, Marta Opalińska
{"title":"Life-Threatening Adrenocortical Carcinoma in Pregnancy: Case Report","authors":"A. Hubalewska-Dydejczyk, W. Nowak, A. Matyja, A. Kasperlik-Załuska, Marie Kmita, J. Gil, Marta Opalińska","doi":"10.1097/TEN.0B013E3181E94730","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181E94730","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"15 1","pages":"149-151"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85941318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-07-01DOI: 10.1097/TEN.0B013E3181E9475B
Wenjun Ou, Jianyun Luo, Qi Lu, Lili Han, Z. Yao
Objective: To investigate the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor beta (ESR2) gene and bone mineral density (BMD) and osteoporotic fracture in postmenopausal women. Methods: Spine and hip BMD as well as fracture history were investigated in 140 postmenopausal Chinese women. Genotyping was performed for 3 SNPs of ESR2 gene, Van91| and Rsa| in exon 5, and AluI in exon 8. For each SNP, subjects were divided into 2 groups: the “carrier group” including individuals with at least 1 allele bearing the restriction site and the “wild-type group” including the rest of the subjects. Results: Only VV genotype was observed for the Van91| locus. The distribution of RsaI genotypes was 81.43% for RR, 17.14% for Rr, 1.43% for rr, and of AluI genotypes was 87.86% for AA and 12.14% for Aa, and aa was absent. Spine BMD differed significantly in the 2 groups of RsaI SNP after adjusting for confounding variables (P = 0.0042), while hip BMD differed significantly in the 2 groups of AluI SNP after adjustment (P 0.05). Conclusions: The RsaI and AluI SNPs of ESR2 gene may influence BMD variation, but does not appear to correlate with the risk of osteoporotic fracture in postmenopausal women.
{"title":"estrogen Receptor Beta Gene Polymorphisms is Correlated With Bone Mineral Density, But Not Osteoporotic Fracture in Postmenopausal Women","authors":"Wenjun Ou, Jianyun Luo, Qi Lu, Lili Han, Z. Yao","doi":"10.1097/TEN.0B013E3181E9475B","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181E9475B","url":null,"abstract":"Objective: To investigate the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor beta (ESR2) gene and bone mineral density (BMD) and osteoporotic fracture in postmenopausal women. Methods: Spine and hip BMD as well as fracture history were investigated in 140 postmenopausal Chinese women. Genotyping was performed for 3 SNPs of ESR2 gene, Van91| and Rsa| in exon 5, and AluI in exon 8. For each SNP, subjects were divided into 2 groups: the “carrier group” including individuals with at least 1 allele bearing the restriction site and the “wild-type group” including the rest of the subjects. Results: Only VV genotype was observed for the Van91| locus. The distribution of RsaI genotypes was 81.43% for RR, 17.14% for Rr, 1.43% for rr, and of AluI genotypes was 87.86% for AA and 12.14% for Aa, and aa was absent. Spine BMD differed significantly in the 2 groups of RsaI SNP after adjusting for confounding variables (P = 0.0042), while hip BMD differed significantly in the 2 groups of AluI SNP after adjustment (P 0.05). Conclusions: The RsaI and AluI SNPs of ESR2 gene may influence BMD variation, but does not appear to correlate with the risk of osteoporotic fracture in postmenopausal women.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"44 1","pages":"174-178"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72909875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-07-01DOI: 10.1097/TEN.0B013E3181E9471E
M. Keskin, O. Keskin, Levent Temel, A. Dai, E. Guler, Y. Kor, Y. Çoşkun
Abstract:Type 1 diabetes mellitus is associated with celiac disease (CD) and Hashimoto thyroiditis. The aim of this study was to determine the frequency of CD and thyroid antibodies in children with Type 1 diabetes mellitus. Data from 134 patients were analyzed from 2003 to 2008. All patients were s
{"title":"Screening Frequency of Celiac Disease and Autoimmune Thyroiditis in Children and Adolescents With Type 1 Diabetes Mellitus in Turkey and Comparison With Last Surveys","authors":"M. Keskin, O. Keskin, Levent Temel, A. Dai, E. Guler, Y. Kor, Y. Çoşkun","doi":"10.1097/TEN.0B013E3181E9471E","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181E9471E","url":null,"abstract":"Abstract:Type 1 diabetes mellitus is associated with celiac disease (CD) and Hashimoto thyroiditis. The aim of this study was to determine the frequency of CD and thyroid antibodies in children with Type 1 diabetes mellitus. Data from 134 patients were analyzed from 2003 to 2008. All patients were s","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"13 1","pages":"171-173"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74763959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-07-01DOI: 10.1097/TEN.0B013E3181E94743
Hai-Long Zhang
Abstract:Brown tumor is rarely seen today, probably because routine serum chemical tests identify patients with primary hyperparathyroidism before this skeletal complication develops. It has the appearance of a well-circumscribed expansible lytic lesion of the bone and is difficult to differentiate
{"title":"Multiple Brown Tumors: A Diagnostic Dilemma","authors":"Hai-Long Zhang","doi":"10.1097/TEN.0B013E3181E94743","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181E94743","url":null,"abstract":"Abstract:Brown tumor is rarely seen today, probably because routine serum chemical tests identify patients with primary hyperparathyroidism before this skeletal complication develops. It has the appearance of a well-circumscribed expansible lytic lesion of the bone and is difficult to differentiate","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"26 1","pages":"152-154"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73026094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-07-01DOI: 10.1097/TEN.0B013E3181E94935
C. Signore
Abstract: The development of thyroid stimulating hormone receptor antibodies (TRAB) and associated Graves disease has been previously described in patients with multinodular goiter after treatment with radioactive iodine. We describe the case of a 72-year-old man with subclinical hyperthyroidism secondary to multinodular goiter who developed TRAB and Graves ophthalmopathy after treatment with radioactive iodine. The patient had become hypothyroid, when his eye disease first made its appearance. This appears to be the first reported case of isolated Graves ophthalmopathy in a patient who was hypothyroid at the time of presentation and who developed TRAB after treatment for multinodular goiter.
{"title":"Graves Ophthalmopathy After Treatment of Subclinical Hyperthyroidism From Multinodular Goiter With Radioactive Iodine","authors":"C. Signore","doi":"10.1097/TEN.0B013E3181E94935","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181E94935","url":null,"abstract":"Abstract: The development of thyroid stimulating hormone receptor antibodies (TRAB) and associated Graves disease has been previously described in patients with multinodular goiter after treatment with radioactive iodine. We describe the case of a 72-year-old man with subclinical hyperthyroidism secondary to multinodular goiter who developed TRAB and Graves ophthalmopathy after treatment with radioactive iodine. The patient had become hypothyroid, when his eye disease first made its appearance. This appears to be the first reported case of isolated Graves ophthalmopathy in a patient who was hypothyroid at the time of presentation and who developed TRAB after treatment for multinodular goiter.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"69 1","pages":"157-159"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80883949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-07-01DOI: 10.1097/TEN.0B013E3181ECB06A
V. Mundra, C. Solórzano, P. Desantis
{"title":"Cushing Syndrome: A Rare Occurrence in Pregnancy","authors":"V. Mundra, C. Solórzano, P. Desantis","doi":"10.1097/TEN.0B013E3181ECB06A","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181ECB06A","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"22 1","pages":"165-167"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84953614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-07-01DOI: 10.1097/TEN.0B013E3181E94869
E. Özkaya, Y. Aydin, B. Özkan,, S. Ozkan, E. Eskioğlu, S. Guler
This study evaluates the effect of L-thyroxin therapy on euthyroid nodular disease. The efficacy of treatment was evaluated by ultrasonography in 62 patients with benign euthyroid nodular goiter. Patients have been subdivided in 2 groups. About 35 patients were treated for 1 year with suppressive doses of thyroxine (study group) and 27 were followed without therapy. After L-thyroxin suppressive treatment, no significant difference was observed in both right and left thyroid lobe volume and dominant nodule volume. Only left thyroid volume significantly increased in control group. In our study, there was no significant effect on nodule volume with L-thyroxin treatment. Only left thyroid volume significantly increased in control (without treatment) group. Thus, the potential risks of long-term L-thyroxine therapy outweigh the potential benefits for most patients.
{"title":"The Effect of Thyroxine-Suppressive Therapy in Patients With Euthyroid Nodular Disease: A Randomized Controlled Study","authors":"E. Özkaya, Y. Aydin, B. Özkan,, S. Ozkan, E. Eskioğlu, S. Guler","doi":"10.1097/TEN.0B013E3181E94869","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181E94869","url":null,"abstract":"This study evaluates the effect of L-thyroxin therapy on euthyroid nodular disease. The efficacy of treatment was evaluated by ultrasonography in 62 patients with benign euthyroid nodular goiter. Patients have been subdivided in 2 groups. About 35 patients were treated for 1 year with suppressive doses of thyroxine (study group) and 27 were followed without therapy. After L-thyroxin suppressive treatment, no significant difference was observed in both right and left thyroid lobe volume and dominant nodule volume. Only left thyroid volume significantly increased in control group. In our study, there was no significant effect on nodule volume with L-thyroxin treatment. Only left thyroid volume significantly increased in control (without treatment) group. Thus, the potential risks of long-term L-thyroxine therapy outweigh the potential benefits for most patients.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"88 1","pages":"182-184"},"PeriodicalIF":0.0,"publicationDate":"2010-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83409711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFDB01
Elena García, J. Macarrón, L. Maza, S. Jiménez, A. Cabello, Miguel Martín, E. Ruiz
{"title":"Diabetes and Mitochondrial Encephalomyopathy","authors":"Elena García, J. Macarrón, L. Maza, S. Jiménez, A. Cabello, Miguel Martín, E. Ruiz","doi":"10.1097/TEN.0B013E3181DFDB01","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFDB01","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"31 1","pages":"105-108"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85926198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFCCF3
A. Gkountouvas, M. Nikas, A. Aggelopoulou, A. Tertipi, P. Georgiadis, A. Pappas, P. Kaldrimidis
{"title":"Brain Metastases Due to Papillary Thyroid Carcinoma: The Malevolent Side of a Bland Neoplasm","authors":"A. Gkountouvas, M. Nikas, A. Aggelopoulou, A. Tertipi, P. Georgiadis, A. Pappas, P. Kaldrimidis","doi":"10.1097/TEN.0B013E3181DFCCF3","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFCCF3","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"50 1","pages":"100-101"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77730169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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