Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFDC98
K. GaneshH., R. Gopal, J. George, T. Bandgar, P. Menon, N. Shah
{"title":"von Hippel-Lindau Disease: A Case Series of Unusual Familial Cancer Syndrome","authors":"K. GaneshH., R. Gopal, J. George, T. Bandgar, P. Menon, N. Shah","doi":"10.1097/TEN.0B013E3181DFDC98","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFDC98","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"24 1","pages":"134-136"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88999826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DEE6B6
C. Zou, Zheng Shen, Xian Chen, L. Liang, Zhengyan Zhao
{"title":"Sex Reversal Syndrome With 47, XYY Karyotype: Case Report and Literature Review","authors":"C. Zou, Zheng Shen, Xian Chen, L. Liang, Zhengyan Zhao","doi":"10.1097/TEN.0B013E3181DEE6B6","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DEE6B6","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"33 1","pages":"98-99"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86332856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFE618
R. Gen, E. Akbay, K. Sezer
Introduction: The aim of this study was to investigate insulin resistance in patients with mild and severe subclinical hypothyroidism (SH), and to explore the relationship between insulin resistance and cardiovascular risk factors. Material and Methods: The study group consisted of 27 women with severe SH (body mass index BMI, 28.35/3.92 kg/m 2 ), 25 women with mild SH (BMI, 27.13/3.16 kg/m 2 ), and 22 healthy women (BMI, 27.365/2.92 kg/m 2 ). The mean systolic blood pressure, diastolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, LDL-cholesterol (LDL-C), triglyceride, thyroid-stimulating hormone (TSH), and high-sensitive CRP (hs-CRP) levels were higher in patients with severe SH than patients with mild SH and control subjects. The mean fasting insulin level, TSH level, LDL-C, and hs-CRP was higher in patients with mild SH than the control group. However, systolic blood pressure, diastolic blood pressure, and HOMA-IR were similar between patients with mild SH and those in the control group. In patients with severe SH, HOMA-IR was positively associated with TSH, total cholesterol, LDL-C, triglyceride, hs-CRP, and diastolic blood pressure but negatively associated with HDL-C. There was no correlation between HOMA-IR and waist circumference, W/H ratio, fT3, fT4, and systolic blood pressure in patients with severe SH. In patients with mild SH, HOMA-IR was positively correlated with TSH and hs-CRP, but there was no correlation between HOMA-IR and other parameters. Conclusion: We conclude that severe SH was associated with increased insulin resistance and increased cardiovascular risk factors such as lipid abnormalities, hypertension, and hs-CRP. Our data also suggest that insulin resistance may play a role in mediating the effects of severe SH on diastolic blood pressure, lipid abnormalities, and low-grade inflammation. Mild SH is associated only with early insulin resistance, LDL-C, and low-grade inflammation.
{"title":"Insulin Resistance and Cardiovascular Risk Factors in Patients With Mild and Severe Subclinical Hypothyroidism","authors":"R. Gen, E. Akbay, K. Sezer","doi":"10.1097/TEN.0B013E3181DFE618","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFE618","url":null,"abstract":"Introduction: The aim of this study was to investigate insulin resistance in patients with mild and severe subclinical hypothyroidism (SH), and to explore the relationship between insulin resistance and cardiovascular risk factors. Material and Methods: The study group consisted of 27 women with severe SH (body mass index BMI, 28.35/3.92 kg/m 2 ), 25 women with mild SH (BMI, 27.13/3.16 kg/m 2 ), and 22 healthy women (BMI, 27.365/2.92 kg/m 2 ). The mean systolic blood pressure, diastolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, LDL-cholesterol (LDL-C), triglyceride, thyroid-stimulating hormone (TSH), and high-sensitive CRP (hs-CRP) levels were higher in patients with severe SH than patients with mild SH and control subjects. The mean fasting insulin level, TSH level, LDL-C, and hs-CRP was higher in patients with mild SH than the control group. However, systolic blood pressure, diastolic blood pressure, and HOMA-IR were similar between patients with mild SH and those in the control group. In patients with severe SH, HOMA-IR was positively associated with TSH, total cholesterol, LDL-C, triglyceride, hs-CRP, and diastolic blood pressure but negatively associated with HDL-C. There was no correlation between HOMA-IR and waist circumference, W/H ratio, fT3, fT4, and systolic blood pressure in patients with severe SH. In patients with mild SH, HOMA-IR was positively correlated with TSH and hs-CRP, but there was no correlation between HOMA-IR and other parameters. Conclusion: We conclude that severe SH was associated with increased insulin resistance and increased cardiovascular risk factors such as lipid abnormalities, hypertension, and hs-CRP. Our data also suggest that insulin resistance may play a role in mediating the effects of severe SH on diastolic blood pressure, lipid abnormalities, and low-grade inflammation. Mild SH is associated only with early insulin resistance, LDL-C, and low-grade inflammation.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"7 1","pages":"128-130"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82364369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFDB14
A. Fridman, Q. Nguyen, E. Plummer
Chronic lithium therapy can adversely affect thyroid, parathyroid, and kidney function. We present a 67-year-old man on chronic lithium therapy for bipolar disorder who developed thyroid storm, hypercalcemia, and nephrogenic diabetes insipidus following lithium intoxication. Diagnostic studies revealed no infectious precipitant of thyroid storm, with negative thyroid stimulating immunoglobulin and antithyroid peroxidase antibody levels. Thyroid ultrasound demonstrated small thyroid glands with decreased blood flow, not suggestive of Graves' disease. The patient's symptoms improved on only a few weeks of antithyroid drug and was discharged home without thyroid medications. His thyroid function followed a thyroiditis pattern when it dipped into the hypothyroid range before returning to normal without further interventions. To our knowledge, this is the first reported case of lithium-induced thyroiditis precipitating a thyroid storm and the third reported occurrence of thyroid storm in the context of thyroiditis. The patient's hospital course was further complicated by the development of hypercalcemia and nephrogenic diabetes insipidus requiring specialized treatments. We review the literature on mechanisms and treatment of lithium-induced thyroid dysfunction, hypercalcemia, and diabetes insipidus. Lithium-treated patients should have periodic thyroid function tests, and electrolyte measurements, especially following lithium dose adjustment.
{"title":"A Case of Lithium-Induced Polyendocrinopathy Including Thyroid Storm:","authors":"A. Fridman, Q. Nguyen, E. Plummer","doi":"10.1097/TEN.0B013E3181DFDB14","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFDB14","url":null,"abstract":"Chronic lithium therapy can adversely affect thyroid, parathyroid, and kidney function. We present a 67-year-old man on chronic lithium therapy for bipolar disorder who developed thyroid storm, hypercalcemia, and nephrogenic diabetes insipidus following lithium intoxication. Diagnostic studies revealed no infectious precipitant of thyroid storm, with negative thyroid stimulating immunoglobulin and antithyroid peroxidase antibody levels. Thyroid ultrasound demonstrated small thyroid glands with decreased blood flow, not suggestive of Graves' disease. The patient's symptoms improved on only a few weeks of antithyroid drug and was discharged home without thyroid medications. His thyroid function followed a thyroiditis pattern when it dipped into the hypothyroid range before returning to normal without further interventions. To our knowledge, this is the first reported case of lithium-induced thyroiditis precipitating a thyroid storm and the third reported occurrence of thyroid storm in the context of thyroiditis. The patient's hospital course was further complicated by the development of hypercalcemia and nephrogenic diabetes insipidus requiring specialized treatments. We review the literature on mechanisms and treatment of lithium-induced thyroid dysfunction, hypercalcemia, and diabetes insipidus. Lithium-treated patients should have periodic thyroid function tests, and electrolyte measurements, especially following lithium dose adjustment.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"34 1","pages":"131-133"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83720345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFFEBB
A. Marić, D. Katalinic, V. Čerina, H. Pećina, M. Vrkljan
{"title":"Sphenopharyngeal Encephalocele Presenting With Partial Hypopituitarism and Diabetes Insipidus: Case Report and Literature Review","authors":"A. Marić, D. Katalinic, V. Čerina, H. Pećina, M. Vrkljan","doi":"10.1097/TEN.0B013E3181DFFEBB","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFFEBB","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"51 1","pages":"109-111"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78293977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DE5C22
D. Karásek, H. Vaverkova, M. Halenka, D. Jackuliaková, Z. Fryšák, Dalibor Novotný Ing
{"title":"Adiponectin in Members of Families With Familial Combined Hyperlipidemia","authors":"D. Karásek, H. Vaverkova, M. Halenka, D. Jackuliaková, Z. Fryšák, Dalibor Novotný Ing","doi":"10.1097/TEN.0B013E3181DE5C22","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DE5C22","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"23 1","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75698632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DE5B20
O. Akgul, S. Ocak, E. Göçmen, M. Koç, M. Tez
{"title":"Clinical Significance of Cellular Microfollicular Lesions in Goiter","authors":"O. Akgul, S. Ocak, E. Göçmen, M. Koç, M. Tez","doi":"10.1097/TEN.0B013E3181DE5B20","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DE5B20","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"13 1","pages":"115-116"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82369766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFDCC2
M. Gama, T. Jonasson, J. Gama, Patrícia Zeni Lima Teixeira de Freitas, Ana Carolina Ossowski, Rafaela Cristina Perraro, B. V. Souza, Gislaine Custódio
{"title":"Extreme Insulin-Resistance Syndrome Associated With Alpha-1 Antitrypsin Deficiency: A Case Report and Literature Review","authors":"M. Gama, T. Jonasson, J. Gama, Patrícia Zeni Lima Teixeira de Freitas, Ana Carolina Ossowski, Rafaela Cristina Perraro, B. V. Souza, Gislaine Custódio","doi":"10.1097/TEN.0B013E3181DFDCC2","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFDCC2","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"56 1","pages":"137-140"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75348223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFCB01
S. R. Santos, M. Ferreira, A. S. Borges, R. M. Pinto, M. L. M. P. Fernandes, P. T. Jorge
{"title":"Thyroid Disorders in Hepatitis C Patients Treated or Not With α-Interferon and Ribavirin","authors":"S. R. Santos, M. Ferreira, A. S. Borges, R. M. Pinto, M. L. M. P. Fernandes, P. T. Jorge","doi":"10.1097/TEN.0B013E3181DFCB01","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFCB01","url":null,"abstract":"","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"10 1","pages":"122-124"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82873576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-05-01DOI: 10.1097/TEN.0B013E3181DFD199
Vishal Gupta, R. Nagpal, S. Venkatraman, A. Patel
Aim: The aim is to describe a very rare case of idiopathic granulomatous hypophysitis presenting as panhypopituitarism on the background of chronic renal failure and type 2 diabetes mellitus. The patient presented with fatigue and episodes of self-terminated hypoglycemia (while on sulfonylurea) as the sole manifestation of panhypopituitarism. The case also highlights the difficulties of identifying patients with hypophysitis in the setting of chronic renal failure. Results: We describe a middle-aged man who presented to us with the sole complaints of early morning fatigue and hypoglycemia (while on glimepiride), with a background history of type 2 diabetes and chronic renal failure. Before visiting our practice, he was repeatedly evaluated for decompensation of renal and cardiovascular disease without much success. When we saw the patient there was no obvious evidence of any endocrine disturbance, especially as the blood pressure was high without any postural drop. It was only when the patient persistently complained of an impaired quality of life due to the fatigue that we decided to chase an endocrine cause for the same. On endocrine evaluation, we diagnosed panhypopituitarism secondary to idiopathic granulomatous hypophysitis. Conclusion: Idiopathic granulomatous hypophysitis is a very rare form of inflammatory pituitary disease. Fewer than 35 cases of biopsy-proven idiopathic granulomatous hypophysitis have been reported in medical literature. This is only the third case of biopsy-proven idiopathic granulomatous hypophysitis reported from India.
{"title":"Idiopathic Granulomatous Hypophysitis Presenting as Panhypopituitarism","authors":"Vishal Gupta, R. Nagpal, S. Venkatraman, A. Patel","doi":"10.1097/TEN.0B013E3181DFD199","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181DFD199","url":null,"abstract":"Aim: The aim is to describe a very rare case of idiopathic granulomatous hypophysitis presenting as panhypopituitarism on the background of chronic renal failure and type 2 diabetes mellitus. The patient presented with fatigue and episodes of self-terminated hypoglycemia (while on sulfonylurea) as the sole manifestation of panhypopituitarism. The case also highlights the difficulties of identifying patients with hypophysitis in the setting of chronic renal failure. Results: We describe a middle-aged man who presented to us with the sole complaints of early morning fatigue and hypoglycemia (while on glimepiride), with a background history of type 2 diabetes and chronic renal failure. Before visiting our practice, he was repeatedly evaluated for decompensation of renal and cardiovascular disease without much success. When we saw the patient there was no obvious evidence of any endocrine disturbance, especially as the blood pressure was high without any postural drop. It was only when the patient persistently complained of an impaired quality of life due to the fatigue that we decided to chase an endocrine cause for the same. On endocrine evaluation, we diagnosed panhypopituitarism secondary to idiopathic granulomatous hypophysitis. Conclusion: Idiopathic granulomatous hypophysitis is a very rare form of inflammatory pituitary disease. Fewer than 35 cases of biopsy-proven idiopathic granulomatous hypophysitis have been reported in medical literature. This is only the third case of biopsy-proven idiopathic granulomatous hypophysitis reported from India.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"295 1","pages":"102-104"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79678515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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