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A statistical integrative analysis method for microRNA and gene expression 微 RNA 和基因表达的统计综合分析方法
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-05-17 DOI: 10.1002/ecj.12449
Keita Kodama, Tomohiro Umezu, Yutaka Fukuoka

MicroRNA (miRNA), a type of non-coding RNA, is known to suppress the expression of target genes and there is an increasing number of studies analyzing various miRNAs in cancer. In an integrated analysis of miRNA and gene expressions, it is often difficult to obtain a significant result with a small amount of data. In this study, we proposed a method that allows integrated analysis even with a small amount of miRNA and gene expression data, and examined its validity. The method is based on a group comparison between target genes having specific functions controlled by a specific miRNA and a background group of randomly selected genes. We conducted a simulation to verify the validity of the proposed method. The simulation results indicated that the method can detect significant differences in expression of target genes controlled by a miRNA showing significant expression change. We then applied the proposed method to real data derived from multiple myeloma cells. As a result, some functions were detected as significantly changed due to a significant change of miRNA.

微RNA(miRNA)是一种非编码RNA,已知能抑制靶基因的表达,越来越多的研究分析了癌症中的各种miRNA。在对 miRNA 和基因表达进行综合分析时,往往很难通过少量数据获得显著结果。在本研究中,我们提出了一种即使只有少量 miRNA 和基因表达数据也能进行综合分析的方法,并检验了其有效性。该方法的基础是将受特定 miRNA 控制的具有特定功能的目标基因与随机选择的背景基因进行分组比较。我们进行了模拟,以验证所提方法的有效性。仿真结果表明,该方法能检测出受 miRNA 控制的目标基因在表达量上的显著差异。然后,我们将提出的方法应用于多发性骨髓瘤细胞的真实数据。结果发现,由于 miRNA 的显著变化,一些功能发生了明显改变。
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引用次数: 0
Development of a virtual reality system that generates prism adaptation for multiple motor units 开发可为多个运动单元生成棱镜适应的虚拟现实系统
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-02-26 DOI: 10.1002/ecj.12441
Takashi Ishida, Hiroki Higa

Conventionally, the adaptive body area for prism adaptation (PA) has been limited to the visible area of prism glasses, especially the unilateral upper limbs. In this study, we developed a virtual reality system that extends PA's adaptive body area. This system sets the visible area of the target and introduces a symbolic representation of the body position to realize a head position adaptation task. As a result, the develped system generates PA not to individual body parts but to a collection of multiple motor units. Furthermore, experimental results in healthy subjects showed that the head position adaptation task could generate PA in the upper trunk system (The upper trunk system is defined as a system consisting of the upper trunk, head, and upper extremities) and displace it to the left anteriorly. Therefore, the head position adaptation task is expected to be effective for the postural correction of USN patients with upper trunk system tilt to the right posteriorly. Moreover, the developed system has potential applications in a wide range of fields, such as detecting cerebellar disorders.

传统上,棱镜适应(PA)的适应身体区域仅限于棱镜眼镜的可见区域,尤其是单侧上肢。在这项研究中,我们开发了一个虚拟现实系统,扩展了 PA 的适应身体区域。该系统设置了目标的可见区域,并引入了身体位置的符号表示,以实现头部位置适应任务。因此,开发的系统产生的 PA 不是针对单个身体部位,而是针对多个运动单元的集合。此外,健康受试者的实验结果表明,头部位置适应任务可在上躯干系统(上躯干系统定义为由上躯干、头部和上肢组成的系统)中产生 PA,并使其向左前方移位。因此,头部位置适应任务有望对上躯干系统向右后倾斜的 USN 患者进行有效的姿势矫正。此外,所开发的系统还有可能应用于检测小脑疾病等广泛领域。
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引用次数: 0
Design of a model-free controller based on predictive functional control 基于预测功能控制的无模型控制器设计
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-02-13 DOI: 10.1002/ecj.12442
Yoichiro Ashida, Masaru Katayama

Intelligent-PID (i-PID) control proposed by Fliess is a simple control algorithm. The controller is designed based on ultra-local model, and consisted of PID type controller and derivatives of reference signal and controlled variables. Authors have considered discrete i-PID controller and its properties, and one of the result was that PD controller was sufficient in discrete time domain. In discrete i-PID controller, PD type controller is still required to ensure convergence of controlled error to zero, and PD type parameters affects convergence property, fast-response property and stability. In this paper, predictive functional control (PFC) based on an ultra-local model is proposed. By introducing of PFC, controlled variable converge to reference value without PD type controller. User-specified parameters of the proposed controller is smaller than the conventional i-PID controller. Characteristics of the proposed controller are compared with discrete i-PID controller by numerical examples.

Fliess 提出的智能 PID(i-PID)控制是一种简单的控制算法。该控制器基于超局部模型设计,由 PID 型控制器以及参考信号和受控变量的导数组成。作者考虑了离散 i-PID 控制器及其特性,结果之一是 PD 控制器在离散时域中是足够的。在离散 i-PID 控制器中,仍需要 PD 类型控制器来确保控制误差收敛为零,而 PD 类型参数会影响收敛特性、快速响应特性和稳定性。本文提出了基于超局部模型的预测功能控制(PFC)。通过引入 PFC,受控变量可收敛至参考值,而无需 PD 类型控制器。与传统的 i-PID 控制器相比,该控制器的用户指定参数更小。通过数值示例比较了拟议控制器与离散 i-PID 控制器的特性。
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引用次数: 0
Investigation of vacuum measurement by nano-gap device 利用纳米间隙装置进行真空测量的研究
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-12-23 DOI: 10.1002/ecj.12440
Kazuki Komiya, Koki Nagata, Hidehiko Yamaoka, Shuichi Date, Yuito Miyashita, Min Yan

Advances in microfabrication technology have enabled electron beam lithography (EB lithography) systems to produce microfabrication on the order of 10 of nanometers. Using this technology, we have fabricated nanogap electrodes that can generate large electric fields at low voltages. The gap between the tips of the fabricated electrodes is 100 nm, and the curvature of each tip is 50 nm. The device was confirmed to work as an electronic vacuum gauge, the device successfully measured vacuum from 10−3 to 1 Pa at the electrode voltage of 3 V.

微细加工技术的进步使电子束光刻(EB)系统能够制造出 10 纳米数量级的微细加工产品。利用这项技术,我们制造出了纳米间隙电极,可以在低电压下产生大电场。制作的电极尖端之间的间隙为 100 纳米,每个尖端的曲率为 50 纳米。经证实,该装置可用作电子真空计,在电极电压为 3 V 时,可成功测量 10-3 至 1 Pa 的真空度。
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引用次数: 0
Cuff-less blood pressure estimation using hetero-core optical fibers 使用异芯光纤进行无袖带血压估算
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-12-14 DOI: 10.1002/ecj.12438
Yuya Koyama, Hiroki Kamada, Kazuhiro Watanabe, Michiko Nishiyama

In this study, we proposed a cuff-less blood pressure measurement using a medical tape sensor with an embedded hetero-core optical fiber. The tape sensor pasted on the skin can directly detect pulse wave signals with a simple measuring device. Pulse transit time (PTT) was obtained from the time difference between the two pulse waveforms at the neck and foot. Systolic blood pressure (SBP) was estimated from PTT and the regression equation. The result shows that the maximum prediction error was 3.8 mmHg in five healthy young subjects. The SBP data were evaluated using a Bland-Altman method to assess the agreement of SBP data estimated by the proposed method with those measured by the cuff-based electronic sphygmomanometer. The mean ± 1.96 standard deviation of the estimated SBP against the reference was −1.3 ± 5.1 mmHg. The results show that the proposed noninvasive blood pressure measurement method can measure blood pressure, and its accuracy is comparable to that of the cuff-based electronic sphygmomanometer.

在这项研究中,我们提出了一种使用嵌入式异芯光纤的医用胶带传感器进行无袖带血压测量的方法。贴在皮肤上的胶带传感器可以直接检测脉搏波信号,测量设备简单。根据颈部和足部两个脉搏波形之间的时间差,可得出脉搏传输时间(PTT)。根据 PTT 和回归方程估算收缩压(SBP)。结果显示,在五名健康的年轻受试者中,最大预测误差为 3.8 mmHg。采用布兰-阿尔特曼法评估了 SBP 数据,以评估拟议方法估算的 SBP 数据与袖带式电子血压计测量的 SBP 数据的一致性。估测的 SBP 与参考值的平均值(± 1.96)个标准差为-1.3 ± 5.1 mmHg。结果表明,拟议的无创血压测量方法可以测量血压,其准确性与袖带式电子血压计相当。
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引用次数: 0
Gas pressure dependence of optical and mechanical properties in a SiCO thin film for optical waveguide by reactive sputtering method 反应溅射法光学波导用 SiCO 薄膜的光学和机械特性与气体压力的关系
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-12-06 DOI: 10.1002/ecj.12435
Hiroyuki Nikkuni, Hiroshi Ito, Yu Takatsuka

In this study, the gas pressure dependence of optical and mechanical characteristics in reactive sputtered SiCO thin films for optical guided-wave pressure sensors was experimentally investigated. Thin films were fabricated by varying the gas pressure from 0.3 to 1.0 Pa at an oxygen flow ratio of 6%, and the gas pressure dependences was clarified. As the gas pressure increased, the optical bandgap of the SiCO thin film increased, resulting in a transparent SiCO films. On the other hand, the refractive index, young's modulus, and hardness decreased with increasing gas pressure. Combining this dependence with the oxygen inflow ratio dependence of the previous study, the first-order approximation formula for the gas pressure and oxygen flow rate ratio for various film characteristics was obtained. Based on this equation, trajectories of equal bandgaps and equal young's moduli on the oxygen flow ratio—gas pressure plane were created on the oxygen influx ratio-gas pressure coordinates, making it easy to fabricate waveguides with desired characteristics.

本研究通过实验研究了用于光学导波压力传感器的反应溅射 SiCO 薄膜的光学和机械特性与气体压力的关系。在氧气流量比为 6% 的条件下,通过改变 0.3 至 1.0 Pa 的气体压力制备了薄膜,并阐明了气体压力的相关性。随着气体压力的增加,SiCO 薄膜的光带隙增大,从而形成了透明的 SiCO 薄膜。另一方面,折射率、杨氏模量和硬度随着气体压力的增加而降低。将这一依赖关系与之前研究中的氧气流入比依赖关系相结合,得到了各种薄膜特性下气体压力和氧气流速比的一阶近似公式。根据该公式,在氧气流入比-气体压力坐标上创建了氧气流入比-气体压力平面上等带隙和等杨氏模量的轨迹,从而轻松制造出具有所需特性的波导。
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引用次数: 0
Analytical method of DC input impedance for stability analysis of IPM motor drive system 用于IPM电机驱动系统稳定性分析的直流输入阻抗分析方法
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-12-05 DOI: 10.1002/ecj.12437
Takaya Karino, Toshiji Kato, Kaoru Inoue

This paper proposes an analytical calculation method of frequency characteristics of DC input impedances of an IPM motor drive system for design and stability analysis by the impedance method. The proposed method is based on an averaged frequency model linearized at an operating point. The developed small-signal model considers control principles and mechanical perturbations. It is an analog and digital mixed model which is controlled by a digital signal processor system. Analysis examples of frequency characteristics for the impedance method by the proposed method are investigated and validated analytically and experimentally.

本文提出了一种分析计算IPM电机驱动系统直流输入阻抗频率特性的方法,用于阻抗法设计和稳定性分析。所提出的方法是基于在工作点线性化的平均频率模型。所开发的小信号模型考虑了控制原理和机械扰动。它是由数字信号处理器系统控制的模拟和数字混合模型。用该方法对阻抗法的频率特性分析实例进行了分析和实验验证。
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引用次数: 0
Study of humidity sensor using α-Fe2O3 as a humidity-sensitive material 以α-Fe2O3为湿度敏感材料的湿度传感器的研究
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-12-02 DOI: 10.1002/ecj.12439
Kosuke Naito, Kyohei Sasaki, Noriaki Ikenaga

In this study, iron oxide thin films are prepared under various heat treatment conditions, and their crystal structures and moisture-sensitive characteristics were evaluated to clarify the usefulness of iron oxide thin films as humidity-sensitive materials for humidity sensors. In addition, the possibility of a humidity sensor with a wide dynamic range was investigated by evaluating the relationship between the film thickness of the iron oxide thin film, the electrode width of the device, and the humidity-sensitive characteristics. As a result, it was found that the crystal structure of α-Fe2O3 exhibits relatively good humidity sensitivity compared to other crystal structures, and that the sensitivity to humidity can be adjusted by appropriately selecting the electrode width and film thickness of the device. Therefore, the α-Fe2O3 thin film may be useful as a moisture-sensitive material for wide dynamic range humidity sensors by appropriately adjusting the film thickness and electrode width.

本研究在不同热处理条件下制备了氧化铁薄膜,并对其晶体结构和湿敏特性进行了评价,以阐明氧化铁薄膜作为湿度传感器湿敏材料的实用性。此外,通过评估氧化铁薄膜的薄膜厚度、器件的电极宽度与湿度敏感特性之间的关系,探讨了宽动态范围湿度传感器的可能性。结果发现,α-Fe2O3晶体结构相对于其他晶体结构具有较好的湿度敏感性,并且可以通过适当选择器件的电极宽度和薄膜厚度来调节对湿度的敏感性。因此,适当调节α-Fe2O3薄膜的厚度和电极宽度,可以作为宽动态范围湿度传感器的湿敏材料。
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引用次数: 0
Development and practice of learning materials for an engineering oriented circuit design workshop for elementary school student 面向工程的小学电路设计工作坊教材的开发与实践
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-12-02 DOI: 10.1002/ecj.12436
Tadashi Ishibashi, Jun Moriyama

This study aimed to develop teaching materials for circuit design and fabrication for elementary school students, and conduct workshops oriented to engineering. First, the content of the circuit design workshop was discussed and it was determined that a connection-focused design would be appropriate. Second, we examined the issue of existing teaching materials. Many of the existing kit materials were not suitable for learning circuit design as it was already completed. In addition, many of them required soldering work, which was too difficult for elementary school students. Hands-on materials that allow students to construct circuits through trial and error were suitable for learning circuit design. Therefore, we developed design and fabrication support materials using a 3D printer and conductive tape. Next, we provided workshop opportunities using developed material, with the theme of “making light-up cards,” wherein elementary school students worked on designing the layout of the components and fabrication. Consequently, students’ conceptual understanding of the connection was improved. All students were able to complete the circuit, with high self-evaluations of satisfaction and understanding suggesting that the activity was engineering-oriented.

本研究旨在为小学学生编写电路设计与制造教材,并举办以工程为导向的工作坊。首先,讨论了电路设计研讨会的内容,并确定以连接为中心的设计是合适的。其次,我们考察了现有教材的问题。许多现有的套件材料不适合学习电路设计,因为它已经完成了。此外,他们中的许多人需要焊接工作,这对小学生来说太难了。让学生通过试错构建电路的动手材料适合学习电路设计。因此,我们使用3D打印机和导电胶带设计和制造支撑材料。接下来,我们提供了使用先进材料的工作坊机会,主题是“制作点亮卡片”,其中小学生设计组件的布局和制作。因此,学生对连接的概念理解得到了提高。所有学生都能完成电路,自我评价的满意度和理解力都很高,这表明该活动是面向工程的。
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引用次数: 0
Autonomous configuration establishment method of wireless network on condition monitoring for coupling and decoupling of railway vehicles 铁道车辆耦合解耦状态监测无线网络自主组态建立方法
IF 0.3 4区 工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-11-13 DOI: 10.1002/ecj.12433
Nagateru Iwasawa, Yuta Hosokawa, Akio Hada, Shogo Mamada, Shuji Harashima, Yasushi Fuwa

In recent years, with the development of IoT, research and development of wireless sensor networks for monitoring has been advanced to monitor the condition of various devices in railway vehicles and notify train crews. In the operation of railway vehicles, the composition may be changed at stations by coupling and decoupling, and it is necessary to set up inter-vehicle wireless network considering them. Therefore, to transmit sensor data in railway vehicles, we propose an autonomous configuration establishment method of wireless network for railway vehicles considering coupling and decoupling.

近年来,随着物联网的发展,无线监测传感器网络的研究和开发得到了推进,以监测轨道车辆中各种设备的状态并通知列车乘员。在轨道车辆运行过程中,由于耦合和解耦等因素,车站内的车辆组成可能发生变化,因此建立车际无线网络是必要的。因此,为了在轨道车辆中传输传感器数据,我们提出了一种考虑耦合和解耦的轨道车辆无线网络自主组态建立方法。
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引用次数: 0
期刊
Electronics and Communications in Japan
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