Pub Date : 2024-07-26DOI: 10.18203/2320-6012.ijrms20242053
Nirmal Babu, Debashis Mondal, Rasbihari Hembram
Background: When surgeons started performing surgeries since 19th century, they have to impose wound on their patients and it is their duty to strive constantly to get these wounds to heal as quickly, reliably and severely as possible, and now the behaviour of surgical wound is largely predictable. This study aims to evaluate the benefits or otherwise between single layer closure and layered closure in a peripheral medical college. Methods: All patients who have undergone emergency exploratory laparotomy in Department of General Surgery, College of Medicine and JNM Hospital, Kalyani Results: In our study, out of 50 patients, most of the patients were >30 years old [19 (38.0%)]. Seven (28.0%) patients were >30 and <61 years of age in group A (mass closure) and 12 (48.0%) patients were >30 years of age in group B (layered closure). Age was not significantly associated with group in group A (mass closure) and group B (layered closure) (p=0.0540). We observed that, mean age was lower in group B (layered closure) (37.7600±14.8304) compared to group A (mass closure) (47.3600±15.0993) though it was statistically significant (p=0.0279). Conclusions: In our study, out of 50 patients, most of the patients were >30 years old and age was not significantly associated with group in group A (mass closure) and group B (layered closure). We found that, male population and female population were equal in both two groups. Sex was significantly related with two groups. We observed that, Band adhesion and Perforated appendix were equal in both groups. Which was not statistically significant.
背景：自 19 世纪以来，外科医生开始实施外科手术，他们必须给病人造成伤口，并有责任不断努力使这些伤口尽可能快地、可靠地、严重地愈合。本研究旨在评估单层闭合与分层闭合在一所外围医学院中的优劣：所有在卡利尼医学院和 JNM 医院普外科接受急诊剖腹探查术的患者：在我们的研究中，50 名患者中大多数年龄超过 30 岁[19 人（38.0%）]。在 B 组（分层闭合）中，有 7 名患者（28.0%）的年龄大于 30 岁和 30 岁。在 A 组（大量闭合）和 B 组（分层闭合）中，年龄与组别无明显关联（P=0.0540）。我们观察到，与 A 组（大量闭合）（47.3600±15.0993）相比，B 组（分层闭合）的平均年龄较低（37.7600±14.8304），但有统计学意义（P=0.0279）：在我们的研究中，50 名患者中大多数年龄大于 30 岁，年龄与 A 组（大量闭合）和 B 组（分层闭合）的组别无明显关联。我们发现，两组中男性和女性的比例相同。性别与两组有明显关系。我们观察到，带状粘连和阑尾穿孔在两组中的比例相同。这在统计学上没有意义。
{"title":"Mass closure versus layered closure of midline laparotomy incisions","authors":"Nirmal Babu, Debashis Mondal, Rasbihari Hembram","doi":"10.18203/2320-6012.ijrms20242053","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20242053","url":null,"abstract":"Background: When surgeons started performing surgeries since 19th century, they have to impose wound on their patients and it is their duty to strive constantly to get these wounds to heal as quickly, reliably and severely as possible, and now the behaviour of surgical wound is largely predictable. This study aims to evaluate the benefits or otherwise between single layer closure and layered closure in a peripheral medical college.\u0000Methods: All patients who have undergone emergency exploratory laparotomy in Department of General Surgery, College of Medicine and JNM Hospital, Kalyani\u0000Results: In our study, out of 50 patients, most of the patients were >30 years old [19 (38.0%)]. Seven (28.0%) patients were >30 and <61 years of age in group A (mass closure) and 12 (48.0%) patients were >30 years of age in group B (layered closure). Age was not significantly associated with group in group A (mass closure) and group B (layered closure) (p=0.0540). We observed that, mean age was lower in group B (layered closure) (37.7600±14.8304) compared to group A (mass closure) (47.3600±15.0993) though it was statistically significant (p=0.0279).\u0000Conclusions: In our study, out of 50 patients, most of the patients were >30 years old and age was not significantly associated with group in group A (mass closure) and group B (layered closure). We found that, male population and female population were equal in both two groups. Sex was significantly related with two groups. We observed that, Band adhesion and Perforated appendix were equal in both groups. Which was not statistically significant.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"41 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.18203/2320-6012.ijrms20241982
Erick Hidrogo O., Reynaldo D. Fierro J., Luis F. Bustamante S., Ángel A. Becerril B., Alan J. Gutiérrez P., Iberia M. Ossa N., Pablo A. Mendoza S., Hector U. Quiroga J.
We present the case of a 20-year-old male who presents multiple traumas of the abdomen 26 days prior to his return to the emergency room. Going again to evaluation with frank data of peritoneal irritation, since there is no hemodynamic commitment, a contrasted abdomen computed tomography (CT) scan is requested, finding a grade III splenic lesion, which is why he is admitted for emergency splenectomy. This case reports a splenic injury with the need for delayed splenectomy.
我们介绍了一例 20 岁男性的病例，他在返回急诊室 26 天前出现腹部多处创伤。再次进行评估时发现腹膜刺激征，由于没有血液动力学指标，因此要求进行腹部造影计算机断层扫描（CT），结果发现脾脏病变达到 III 级，这就是他入院接受急诊脾脏切除术的原因。本病例报告了一起需要延迟进行脾脏切除术的脾脏损伤。
{"title":"Delayed splenic rupture following abdominal trauma: a case report","authors":"Erick Hidrogo O., Reynaldo D. Fierro J., Luis F. Bustamante S., Ángel A. Becerril B., Alan J. Gutiérrez P., Iberia M. Ossa N., Pablo A. Mendoza S., Hector U. Quiroga J.","doi":"10.18203/2320-6012.ijrms20241982","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241982","url":null,"abstract":"We present the case of a 20-year-old male who presents multiple traumas of the abdomen 26 days prior to his return to the emergency room. Going again to evaluation with frank data of peritoneal irritation, since there is no hemodynamic commitment, a contrasted abdomen computed tomography (CT) scan is requested, finding a grade III splenic lesion, which is why he is admitted for emergency splenectomy. This case reports a splenic injury with the need for delayed splenectomy.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"21 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141814548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.18203/2320-6012.ijrms20241980
R. H. Setyaningrum, Arif Setyobudi, Debree Setiawan, Damar Upahita, Anisa Nindiasari
Background: Cesarean section is one form of surgical procedure involving incision of the abdominal and uterine walls, which poses a risk of postoperative pain. Pain is a common issue experienced by women after cesarean section, particularly within the first 48 hours. Uncontrolled pain can lead to physical and psychological complications such as postpartum depression and difficulties in infant care. Pain management may involve pharmacological therapy, but non-pharmacological alternatives such as relaxation therapy like guided imagery need to be explored, which can help reduce post-cesarean section pain. Methods: This study is experimental, utilizing a randomized controlled trial pre-test and post-test control group double-blind design. The research was conducted from July to September 2022. A simple randomized sampling technique was employed, with a sample size of 32 post-cesarean section patients divided into two groups: the treatment group (guided imagery and standard therapy) consisting of 16 patients, and the control group (standard therapy) consisting of 16 patients. Results: The study revealed a decrease in visual analogue score (VAS) scores by -2.875±0.619 with an effect size of 0.641 in the treatment group. The study had a significant impact with a p value of 0.000 (p<0.05). Conclusions: Guided imagery is effective in reducing the pain level of post-cesarean section patients.
{"title":"The effect of guided imagery on pain levels in post-caesarean section patients","authors":"R. H. Setyaningrum, Arif Setyobudi, Debree Setiawan, Damar Upahita, Anisa Nindiasari","doi":"10.18203/2320-6012.ijrms20241980","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241980","url":null,"abstract":"Background: Cesarean section is one form of surgical procedure involving incision of the abdominal and uterine walls, which poses a risk of postoperative pain. Pain is a common issue experienced by women after cesarean section, particularly within the first 48 hours. Uncontrolled pain can lead to physical and psychological complications such as postpartum depression and difficulties in infant care. Pain management may involve pharmacological therapy, but non-pharmacological alternatives such as relaxation therapy like guided imagery need to be explored, which can help reduce post-cesarean section pain.\u0000Methods: This study is experimental, utilizing a randomized controlled trial pre-test and post-test control group double-blind design. The research was conducted from July to September 2022. A simple randomized sampling technique was employed, with a sample size of 32 post-cesarean section patients divided into two groups: the treatment group (guided imagery and standard therapy) consisting of 16 patients, and the control group (standard therapy) consisting of 16 patients.\u0000Results: The study revealed a decrease in visual analogue score (VAS) scores by -2.875±0.619 with an effect size of 0.641 in the treatment group. The study had a significant impact with a p value of 0.000 (p<0.05).\u0000Conclusions: Guided imagery is effective in reducing the pain level of post-cesarean section patients.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"9 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141814718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.18203/2320-6012.ijrms20241981
Karla P. Vidaurri, Kimberly O. Bojórquez, Erubiel T. Lopez, José A. Arvizu, María M. Gracia
Temporal clipping of the external carotid artery for tumor resection is rarely documented in our country; nevertheless, it proves to be an effective and safe alternative therapeutic approach for reducing blood flow to the tumor and facilitating complete resection. This study presents a clinical case of a patient with a large facial neurofibroma where this technique was successfully employed without complications.
{"title":"Temporary clipping of the external carotid artery in the resection of a massive facial neurofibroma: a case report","authors":"Karla P. Vidaurri, Kimberly O. Bojórquez, Erubiel T. Lopez, José A. Arvizu, María M. Gracia","doi":"10.18203/2320-6012.ijrms20241981","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241981","url":null,"abstract":"Temporal clipping of the external carotid artery for tumor resection is rarely documented in our country; nevertheless, it proves to be an effective and safe alternative therapeutic approach for reducing blood flow to the tumor and facilitating complete resection. This study presents a clinical case of a patient with a large facial neurofibroma where this technique was successfully employed without complications.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"80 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pyloric hypertrophy is a benign condition characterized by narrowing of the pyloric canal, which may be associated with other pathologies. It is believed to manifest as a mild form of hypertrophy from childhood into adulthood. Symptoms can be nonspecific, such as nausea, vomiting, oral intolerance, and weight loss. Diagnosis can be challenging for physicians, and accurate reporting of cases is difficult due to some patients remaining asymptomatic.
{"title":"Pyloric hypertrophy in adults: case report","authors":"Mariana Gonzalez Villegas, Fernanda Vega Robles, Kimberly Bojórquez Osuna, Hector Fregoso Lomeli, Ricardo Macedo Belloso","doi":"10.18203/2320-6012.ijrms20241979","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241979","url":null,"abstract":"Pyloric hypertrophy is a benign condition characterized by narrowing of the pyloric canal, which may be associated with other pathologies. It is believed to manifest as a mild form of hypertrophy from childhood into adulthood. Symptoms can be nonspecific, such as nausea, vomiting, oral intolerance, and weight loss. Diagnosis can be challenging for physicians, and accurate reporting of cases is difficult due to some patients remaining asymptomatic.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"112 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.18203/2320-6012.ijrms20241972
Rishabh Arora, V. Holla
A diverse range of bone growth disorders known as skeletal dysplasias are brought on by new mutations in the FGFR3 gene, which cause abnormalities in the size and shape of the skeleton. We present a case of thanatophoric dysplasia diagnosed antenatally on ultrasound. G2P1L0, a 30-year-old woman, came to our radiodiagnosis department for her first pregnant ultrasound examination. The results showed a single live intrauterine baby with a head that was considerably bigger than the rest of the body, a hypoplastic nasal bone, an exceedingly thin fetal thorax, thicker soft tissue in the hands and feet, as well as bent long bones that resemble telephone receiver handles, along with bilateral club feet and trident hands.
{"title":"Thanatophoric skeletal dysplasia: a rare case report","authors":"Rishabh Arora, V. Holla","doi":"10.18203/2320-6012.ijrms20241972","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241972","url":null,"abstract":"A diverse range of bone growth disorders known as skeletal dysplasias are brought on by new mutations in the FGFR3 gene, which cause abnormalities in the size and shape of the skeleton. We present a case of thanatophoric dysplasia diagnosed antenatally on ultrasound. G2P1L0, a 30-year-old woman, came to our radiodiagnosis department for her first pregnant ultrasound examination. The results showed a single live intrauterine baby with a head that was considerably bigger than the rest of the body, a hypoplastic nasal bone, an exceedingly thin fetal thorax, thicker soft tissue in the hands and feet, as well as bent long bones that resemble telephone receiver handles, along with bilateral club feet and trident hands.\u0000 ","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.18203/2320-6012.ijrms20241971
Shubham P. Theng, Rajesh J. Khyalappa
Background: Snake bite is a common acute medical emergency faced by rural populations in tropical and subtropical countries. In India, a large proportion of snake bites occur when people are working barefoot in the fields or while walking at night. More than 2,000 species of snakes are known worldwide, of which around 400 are poisonous. These snakes belong to the families Elapidae, Viperidae, Hydrophiidae and Colubridae. Methods: A prospective was done at medicine department of SDH Sawantwadi, Sindhudurgh. Study duration was 3 months (May 2023 to July 2023). Study population included all cases admitted in SDH Sawantwadi with history of snake bite. Sample size was 50. Results: Majority of cases found in the age group of 18-30 years 19 cases (38%) followed by 9 cases in 31-45 age group, 12 in 46-60 age group and 10 cases in 61 and above group. Majority of patients with history of snake bite were males contributing 27 (54%). Snake bites were more common in males as compared to females 23 (46%). 14% snake bite cases have activated partial thromboplastin time (APTT) >30 seconds, 10% of snake bite cases had prothrombin time (PT) >15 sec, 30% had platelet count <100000, increased leucocyte count >11000 was seen in 22% cases and 12% victims showed whole blood clotting test (WBCT) >20 minutes. Clinical outcome was 90% discharged after treatment and 10% death during treatment. Correlation between PT and clinical outcome is significant at p<0.5. Conclusions: Association between PT and mortality among snake bite patients was statistically significant.
{"title":"Study clinical features, haematological changes and outcome in snake bite cases","authors":"Shubham P. Theng, Rajesh J. Khyalappa","doi":"10.18203/2320-6012.ijrms20241971","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241971","url":null,"abstract":"Background: Snake bite is a common acute medical emergency faced by rural populations in tropical and subtropical countries. In India, a large proportion of snake bites occur when people are working barefoot in the fields or while walking at night. More than 2,000 species of snakes are known worldwide, of which around 400 are poisonous. These snakes belong to the families Elapidae, Viperidae, Hydrophiidae and Colubridae.\u0000Methods: A prospective was done at medicine department of SDH Sawantwadi, Sindhudurgh. Study duration was 3 months (May 2023 to July 2023). Study population included all cases admitted in SDH Sawantwadi with history of snake bite. Sample size was 50.\u0000Results: Majority of cases found in the age group of 18-30 years 19 cases (38%) followed by 9 cases in 31-45 age group, 12 in 46-60 age group and 10 cases in 61 and above group. Majority of patients with history of snake bite were males contributing 27 (54%). Snake bites were more common in males as compared to females 23 (46%). 14% snake bite cases have activated partial thromboplastin time (APTT) >30 seconds, 10% of snake bite cases had prothrombin time (PT) >15 sec, 30% had platelet count <100000, increased leucocyte count >11000 was seen in 22% cases and 12% victims showed whole blood clotting test (WBCT) >20 minutes. Clinical outcome was 90% discharged after treatment and 10% death during treatment. Correlation between PT and clinical outcome is significant at p<0.5.\u0000Conclusions: Association between PT and mortality among snake bite patients was statistically significant.\u0000 ","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":" 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.18203/2320-6012.ijrms20241968
Pramila Kalra, M. Dharmalingam, Samir Kubba, H. Bhojwani, Sanjay Jain
Background: Type 2 diabetes mellitus (T2DM) is a prevalent condition, with a significant burden in India, affecting approximately 74.2 million individuals. Vildagliptin, a selective dipeptidyl peptidase 4 (DPP-4) inhibitor, is approved globally for monotherapy and combination therapy. Recently, it became available as a generic product, which increased its accessibility to patients. This study aimed to assess the knowledge, attitude, and practice (KAP) regarding vildagliptin and its combination in T2DM management. Methods: A pan-India cross-sectional KAP survey was conducted from February 2022 to March 2023. The survey utilized a specially designed questionnaire focusing on various aspects of vildagliptin treatment. A total of 1,440 healthcare professionals (HCPs) with recognized qualifications and experience in diabetes management participated. Descriptive statistics were employed for data analysis. Results: HCPs reported initiating Vildagliptin monotherapy at an HbA1c 6.5-7.5%, while combination therapy with vildagliptin and metformin at HbA1c 7-8%. Vildagliptin was primarily preferred as an add-on to metformin. Inadequate HbA1c control with existing therapy emerged as the primary trigger for switching to vildagliptin and metformin combination. Treatment-naïve T2DM patients with HbA1c 1.5% above target and those uncontrolled on metformin monotherapy or dual therapy were reported to benefit most from combination therapy. Combination therapy was reported to result in a glycemic reduction of 1.0-1.5%. HCPs perceived vildagliptin better than other DPP4 inhibitors due to its efficacy in reducing HbA1c and a lower risk of hypoglycemia. Conclusions: The KAP survey highlights the value Indian HCPs place on the effectiveness and tolerability of vildagliptin and their attitudes and practices in its use, highlighting its clinical utility in routine practice.
{"title":"Role of vildagliptin and its combination in type 2 diabetes mellitus management: a knowledge, attitude, and practice survey among Indian healthcare professionals","authors":"Pramila Kalra, M. Dharmalingam, Samir Kubba, H. Bhojwani, Sanjay Jain","doi":"10.18203/2320-6012.ijrms20241968","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241968","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is a prevalent condition, with a significant burden in India, affecting approximately 74.2 million individuals. Vildagliptin, a selective dipeptidyl peptidase 4 (DPP-4) inhibitor, is approved globally for monotherapy and combination therapy. Recently, it became available as a generic product, which increased its accessibility to patients. This study aimed to assess the knowledge, attitude, and practice (KAP) regarding vildagliptin and its combination in T2DM management.\u0000Methods: A pan-India cross-sectional KAP survey was conducted from February 2022 to March 2023. The survey utilized a specially designed questionnaire focusing on various aspects of vildagliptin treatment. A total of 1,440 healthcare professionals (HCPs) with recognized qualifications and experience in diabetes management participated. Descriptive statistics were employed for data analysis.\u0000Results: HCPs reported initiating Vildagliptin monotherapy at an HbA1c 6.5-7.5%, while combination therapy with vildagliptin and metformin at HbA1c 7-8%. Vildagliptin was primarily preferred as an add-on to metformin. Inadequate HbA1c control with existing therapy emerged as the primary trigger for switching to vildagliptin and metformin combination. Treatment-naïve T2DM patients with HbA1c 1.5% above target and those uncontrolled on metformin monotherapy or dual therapy were reported to benefit most from combination therapy. Combination therapy was reported to result in a glycemic reduction of 1.0-1.5%. HCPs perceived vildagliptin better than other DPP4 inhibitors due to its efficacy in reducing HbA1c and a lower risk of hypoglycemia.\u0000Conclusions: The KAP survey highlights the value Indian HCPs place on the effectiveness and tolerability of vildagliptin and their attitudes and practices in its use, highlighting its clinical utility in routine practice.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Overactive bladder (OAB) is identified by urinary urgency, with or without urgency urinary incontinence, typically accompanied by increased daytime urinary frequency and nocturia, in the absence of proven infection or other evident pathology. Methods: A cross-sectional, observational, questionnaire-based knowledge, attitude, and practice (KAP) survey was conducted across India from January 2022 to July 2023 to understand OAB therapy through 14 multiple–choice questions containing questionnaire shared with 1, 029 healthcare professionals (HCPs), including urologists, surgeons, nephrologists, and consulting physicians. Results: The HCPs see 10-20% of patients daily in clinical practice, wherein 5-10% are females. Patients usually consult general practitioners first and then other specialists. Although anticholinergics are commonly used in the management of OAB, HCPs reported that side effects (57%) and the high cost of therapy (43%) were mainly responsible for discontinuing anticholinergics. Mirabegron was preferred by 67% of HCPs in the treatment of these patients. Mirabegron is also preferred as a first-line treatment by all HCPs in this survey. It is prescribed for 6-12 months, has a response rate of >75% in clinical practice, and offers a more favourable side-effect profile compared to anticholinergics. In cases where patients do not respond to anticholinergics or experience treatment failure, a combination therapy of mirabegron and solifenacin is preferred. Conclusions: The survey highlights the use of mirabegron as a first-line treatment for OAB, its better side-effect profile, and its role in combination therapy with solifenacin for patients unresponsive to anticholinergics, ultimately improving the quality of life of patients.
{"title":"Role of mirabegron in the management of overactive bladder: a knowledge, attitude, and practice survey among Indian healthcare professionals","authors":"Madhu Sudan Agrawal, Sanjay Pandey, Prem Kumar, Vikram Sahu, Dinesh Patil","doi":"10.18203/2320-6012.ijrms20241963","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20241963","url":null,"abstract":"Background: Overactive bladder (OAB) is identified by urinary urgency, with or without urgency urinary incontinence, typically accompanied by increased daytime urinary frequency and nocturia, in the absence of proven infection or other evident pathology.\u0000Methods: A cross-sectional, observational, questionnaire-based knowledge, attitude, and practice (KAP) survey was conducted across India from January 2022 to July 2023 to understand OAB therapy through 14 multiple–choice questions containing questionnaire shared with 1, 029 healthcare professionals (HCPs), including urologists, surgeons, nephrologists, and consulting physicians.\u0000Results: The HCPs see 10-20% of patients daily in clinical practice, wherein 5-10% are females. Patients usually consult general practitioners first and then other specialists. Although anticholinergics are commonly used in the management of OAB, HCPs reported that side effects (57%) and the high cost of therapy (43%) were mainly responsible for discontinuing anticholinergics. Mirabegron was preferred by 67% of HCPs in the treatment of these patients. Mirabegron is also preferred as a first-line treatment by all HCPs in this survey. It is prescribed for 6-12 months, has a response rate of >75% in clinical practice, and offers a more favourable side-effect profile compared to anticholinergics. In cases where patients do not respond to anticholinergics or experience treatment failure, a combination therapy of mirabegron and solifenacin is preferred.\u0000Conclusions: The survey highlights the use of mirabegron as a first-line treatment for OAB, its better side-effect profile, and its role in combination therapy with solifenacin for patients unresponsive to anticholinergics, ultimately improving the quality of life of patients.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-23DOI: 10.18203/2320-6012.ijrms20240036
Ponce-Hernandez Jonathan M., Xicohtencatl-Mendoza M. Del Carmen, Ponce-Xicohtencatl Jonathan E., Rivera-Sánchez Gilberto R., Calderon-Hernandez Daniel, Torre-Anaya Erik A., Banegas-Ruíz Rodrigo
Advances in perforating artery flaps have improved reconstruction in various body parts, particularly the lower extremities, offering benefits in patient quality of life and reduced public health service costs. The use of flaps and microsurgery extends beyond trauma to address conditions like osteomyelitis, tumor resection, osteoarthritis, and post-radiation necrosis. Notably, the superficial circumflex iliac artery perforator flap (SCIP) is highlighted for its thin profile and utility in limb coverage, minimizing donor site morbidity. Microsurgical techniques contribute to limb salvage, reducing amputation risks in severe fractures and post-osteosynthesis complications. A 29-year-old male with cerebral palsy suffered bimalleolar fracture from a high-energy motor vehicle accident. Initial ALT flap reconstruction failed, leading to flap removal and osteosynthesis exposure. After 48 hours, removal of the flap was necessary due to venous thrombosis. Salvage with SCIP flap involved anastomosis to perforators of both posterior tibial artery and vein. This case details a patient with a bimalleolar fracture post-motorcycle accident, initially treated with conventional microsurgery using an ALT flap. Complications arose from venous thrombosis, necessitating flap removal. Salvage was achieved through a SCIP flap with supermicrosurgery techniques, employing 0.5 mm anastomosis for improved functionality and reduced complications in flap recovery and donor site comorbidities. Successful outcomes in microsurgery and supermicrosurgery necessitate comprehensive training. Specialized limb salvage centers must possess specific equipment and instruments for these techniques. The literature reviewed doesn't indicate contraindications related to the patient's mental state for the execution of microsurgery and supermicrosurgery.
穿孔动脉皮瓣技术的进步改善了身体各部位（尤其是下肢）的重建，提高了患者的生活质量，降低了公共卫生服务成本。皮瓣和显微外科的应用已超出创伤范围，可用于治疗骨髓炎、肿瘤切除、骨关节炎和放疗后坏死等疾病。值得注意的是，髂浅周动脉穿孔肌皮瓣（SCIP）因其纤细的外形和在肢体覆盖方面的实用性而备受瞩目，并最大限度地降低了供体部位的发病率。显微外科技术有助于挽救肢体，降低严重骨折和骨合成术后并发症的截肢风险。一名患有脑瘫的 29 岁男性因高能量机动车事故导致双侧股骨骨折。最初的ALT皮瓣重建失败，导致皮瓣移除和骨合成暴露。48 小时后，由于静脉血栓形成，必须切除皮瓣。使用SCIP皮瓣进行抢救时，需要吻合胫后动脉和静脉的穿孔。本病例详细描述了一名摩托车事故后双侧股骨骨折的患者，最初使用 ALT 皮瓣进行传统显微外科治疗。静脉血栓形成导致并发症，必须切除皮瓣。通过使用超显微外科技术的 SCIP 皮瓣进行了抢救，采用 0.5 毫米吻合器提高了功能性，减少了皮瓣恢复和供体部位并发症。显微外科手术和超显微外科手术的成功需要全面的培训。专业的肢体救治中心必须为这些技术配备特定的设备和器械。所查阅的文献并没有指出与患者精神状态有关的实施显微外科和超显微外科手术的禁忌症。
{"title":"Failed limb salvage by microsurgery, resolved by super-microsurgery","authors":"Ponce-Hernandez Jonathan M., Xicohtencatl-Mendoza M. Del Carmen, Ponce-Xicohtencatl Jonathan E., Rivera-Sánchez Gilberto R., Calderon-Hernandez Daniel, Torre-Anaya Erik A., Banegas-Ruíz Rodrigo","doi":"10.18203/2320-6012.ijrms20240036","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20240036","url":null,"abstract":"Advances in perforating artery flaps have improved reconstruction in various body parts, particularly the lower extremities, offering benefits in patient quality of life and reduced public health service costs. The use of flaps and microsurgery extends beyond trauma to address conditions like osteomyelitis, tumor resection, osteoarthritis, and post-radiation necrosis. Notably, the superficial circumflex iliac artery perforator flap (SCIP) is highlighted for its thin profile and utility in limb coverage, minimizing donor site morbidity. Microsurgical techniques contribute to limb salvage, reducing amputation risks in severe fractures and post-osteosynthesis complications. A 29-year-old male with cerebral palsy suffered bimalleolar fracture from a high-energy motor vehicle accident. Initial ALT flap reconstruction failed, leading to flap removal and osteosynthesis exposure. After 48 hours, removal of the flap was necessary due to venous thrombosis. Salvage with SCIP flap involved anastomosis to perforators of both posterior tibial artery and vein. This case details a patient with a bimalleolar fracture post-motorcycle accident, initially treated with conventional microsurgery using an ALT flap. Complications arose from venous thrombosis, necessitating flap removal. Salvage was achieved through a SCIP flap with supermicrosurgery techniques, employing 0.5 mm anastomosis for improved functionality and reduced complications in flap recovery and donor site comorbidities. Successful outcomes in microsurgery and supermicrosurgery necessitate comprehensive training. Specialized limb salvage centers must possess specific equipment and instruments for these techniques. The literature reviewed doesn't indicate contraindications related to the patient's mental state for the execution of microsurgery and supermicrosurgery.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"123 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：