Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20233978
Nimisoere Peace Batubo, O. Ogbu, D. Victor
Background: Terminalia catappa nut possesses antioxidant and anticancer properties, but its effects on leukemia are unclear. This study investigates the effects of n-hexane extract of Terminalia catappa nut (TCN) on some hematological parameters, oxidative stress markers, and bone/spleen histopathology in a Wistar rat model of benzene-induced leukemia. Methods: Leukemia was induced in Wistar rats with 0.2 ml/kg Benzene solution and treated with 200, 400 or 800 mg/kg/day of Terminalia catappa nut extract (TCN) for 42 days and with 5-fluorouracil (20 mg/kg) via intraperitoneal injection twice a week for 6 weeks. Hematological parameters, antioxidant markers, and bone and spleen histology were analysed. Results: All TCN doses significantly lowered elevated WBCs by 32-53% and normalized RBC parameters compared to leukemic controls, mitigating cancer-induced anemia. TCN also exhibited potent antioxidant effects by enhancing SOD, GSH, and catalase while reducing MDA versus untreated rats. Bone marrow analysis revealed TCN conferred dose-dependent benefits on cellularity and architecture, reducing myeloid blasts and leukocyte infiltration. A near-normal bone microarchitecture was attained with the highest TCN dose. Similarly, TCN elicited marked improvements in splenic cytoarchitecture and attenuation of hypercellularity, lymphocytic infiltration and megakaryocytes compared to leukemic controls in a dose-dependent manner. Conclusions: Terminalia catappa nut extract demonstrated anti-leukemic, haematopoietic, antioxidant, and organ protective effects in leukemic Wistar rats induced with benzene solution, supporting its potential as an adjuvant therapeutic agent.
{"title":"Hematological, histopathological and oxidative stress responses to n-hexane extract of Terminalia catappa nuts in leukemia-induced Wistar rats","authors":"Nimisoere Peace Batubo, O. Ogbu, D. Victor","doi":"10.18203/2320-6012.ijrms20233978","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233978","url":null,"abstract":"Background: Terminalia catappa nut possesses antioxidant and anticancer properties, but its effects on leukemia are unclear. This study investigates the effects of n-hexane extract of Terminalia catappa nut (TCN) on some hematological parameters, oxidative stress markers, and bone/spleen histopathology in a Wistar rat model of benzene-induced leukemia. Methods: Leukemia was induced in Wistar rats with 0.2 ml/kg Benzene solution and treated with 200, 400 or 800 mg/kg/day of Terminalia catappa nut extract (TCN) for 42 days and with 5-fluorouracil (20 mg/kg) via intraperitoneal injection twice a week for 6 weeks. Hematological parameters, antioxidant markers, and bone and spleen histology were analysed. Results: All TCN doses significantly lowered elevated WBCs by 32-53% and normalized RBC parameters compared to leukemic controls, mitigating cancer-induced anemia. TCN also exhibited potent antioxidant effects by enhancing SOD, GSH, and catalase while reducing MDA versus untreated rats. Bone marrow analysis revealed TCN conferred dose-dependent benefits on cellularity and architecture, reducing myeloid blasts and leukocyte infiltration. A near-normal bone microarchitecture was attained with the highest TCN dose. Similarly, TCN elicited marked improvements in splenic cytoarchitecture and attenuation of hypercellularity, lymphocytic infiltration and megakaryocytes compared to leukemic controls in a dose-dependent manner. Conclusions: Terminalia catappa nut extract demonstrated anti-leukemic, haematopoietic, antioxidant, and organ protective effects in leukemic Wistar rats induced with benzene solution, supporting its potential as an adjuvant therapeutic agent.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"6 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20234017
Abhilasha B. Patil, Komal D. Thorat
Stroke is the third most common cause of death in the world and most common cause of adult disability of the survivors. Balance problems in stroke is very common, and they have been implicated in the poor recovery of activities of daily living (ADL) and mobility and an increased risk of falls. They also have altered in body weight distribution patterns, so that less body weight is taken through the weaker leg have smaller excursions when moving their weight toward the base of support, mostly in the direction of the weaker leg. My fitness trainer (MFT) balance board consists of a uniaxial unstable platform with an integrated sensor, which records all discrepancies in the plane. A 30-year-old female who has history of stroke 4 year ago has chief complain of weakness of upper limb and lower limb and unable to maintain dynamic balance. In this study we assessed the patient on berg balance scale and my fit trainer balance board with pre score and post score which shows significant improvement in results. The Berg balance scale measure score from 37/56 pre-treatment to 48/56 post treatment which shows significance increase in berg balance scale. The MFT balance board measure score from 4.2 disappointed stability in 30 seconds pre-treatment and 3.4 improve stability in 120 seconds post treatment which shows significance increase in MFT balance board. It concluded that there is effect of MFT to improve balance in chronic stroke patient.
{"title":"Effect of my fit trainer for balance rehabilitation in chronic stroke patient: a case study","authors":"Abhilasha B. Patil, Komal D. Thorat","doi":"10.18203/2320-6012.ijrms20234017","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234017","url":null,"abstract":"Stroke is the third most common cause of death in the world and most common cause of adult disability of the survivors. Balance problems in stroke is very common, and they have been implicated in the poor recovery of activities of daily living (ADL) and mobility and an increased risk of falls. They also have altered in body weight distribution patterns, so that less body weight is taken through the weaker leg have smaller excursions when moving their weight toward the base of support, mostly in the direction of the weaker leg. My fitness trainer (MFT) balance board consists of a uniaxial unstable platform with an integrated sensor, which records all discrepancies in the plane. A 30-year-old female who has history of stroke 4 year ago has chief complain of weakness of upper limb and lower limb and unable to maintain dynamic balance. In this study we assessed the patient on berg balance scale and my fit trainer balance board with pre score and post score which shows significant improvement in results. The Berg balance scale measure score from 37/56 pre-treatment to 48/56 post treatment which shows significance increase in berg balance scale. The MFT balance board measure score from 4.2 disappointed stability in 30 seconds pre-treatment and 3.4 improve stability in 120 seconds post treatment which shows significance increase in MFT balance board. It concluded that there is effect of MFT to improve balance in chronic stroke patient.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20234014
Girraj Prasad Sharma, Jagriti Chauhan
Fetus in fetu (FIF) is an extremely rare condition in which malformed twin develop inside the body of living twin. It is most commonly found within the retroperitoneum. Currently, at least 200 cases have been reported across the globe, yet very few instances seen in India. We describe a case of five months old infant born via normal vaginal delivery. She had a firm palpable mass measuring 7×10×7 cm in the left hypochondriac epigastric region crossing midline. A preoperative diagnosis of FIF was made by using ultrasonography (USG) and computed tomography (CT). An exploratory laparotomy and excision of mass was performed successfully. The excised mass was proven to be FIF on the basis of gross and histopathological examination. Even though teratoma is a differential diagnosis, surgical removal is the most suitable treatment method.
胎儿畸形（Fetus in fetu，FIF）是一种极其罕见的情况，即畸形双胞胎在活着的双胞胎体内发育。它最常见于腹膜后。目前，全球至少有 200 个病例被报道，但在印度却很少见。我们描述了一例通过正常阴道分娩出生的五个月大婴儿的病例。她的左侧下腹上腹部有一个可触及的坚实肿块，大小为 7×10×7 厘米，横跨中线。术前通过超声波（USG）和计算机断层扫描（CT）确诊为 FIF。成功进行了探查性开腹手术并切除了肿块。根据大体和组织病理学检查，切除的肿块被证实为 FIF。尽管畸胎瘤是一种鉴别诊断，但手术切除是最合适的治疗方法。
{"title":"Fetus in fetu: rare Indian case of infancy","authors":"Girraj Prasad Sharma, Jagriti Chauhan","doi":"10.18203/2320-6012.ijrms20234014","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234014","url":null,"abstract":"Fetus in fetu (FIF) is an extremely rare condition in which malformed twin develop inside the body of living twin. It is most commonly found within the retroperitoneum. Currently, at least 200 cases have been reported across the globe, yet very few instances seen in India. We describe a case of five months old infant born via normal vaginal delivery. She had a firm palpable mass measuring 7×10×7 cm in the left hypochondriac epigastric region crossing midline. A preoperative diagnosis of FIF was made by using ultrasonography (USG) and computed tomography (CT). An exploratory laparotomy and excision of mass was performed successfully. The excised mass was proven to be FIF on the basis of gross and histopathological examination. Even though teratoma is a differential diagnosis, surgical removal is the most suitable treatment method.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20233982
Satnam Singh, Amandeep Saini, R. G. Saini
Background: Medicinal plants are rich in a wide variety of secondary metabolites such as tannins, alkaloids, phenolic compounds, flavonoids etc. which have the capability to inhibit many pathways that lead to cancer. The present study was conducted with the objectives to screen the extracts of dried roots Gloriosa superba L., dried roots of Centaurea behen L. dried fruits/beads of Elaeocarpus ganitrus Roxb., dried leaves of Ficus religiosa L. and investigate their antitumor activity on human breast cancer cell lines (MDA-MB 231). Methods: Cytotoxic activity was evaluated against non-cancerous cell lines (MCF-10A). Hexane, chloroform, methanol and water were the solvents used for extraction of phytoconstituents by Soxhlet method. Anti-proliferative potential of the plant extracts was evaluated using MTT assay. The trypan blue dye exclusion test was used to determine the number of viable cells present in a cell suspension. Results: On MDA MB-231 cell lines, 91.94% cell death was reported with G. superba aqueous extract followed by E. ganitrus methanol extract and F. religiosa hexane extract with 87.93% and 81.61% cell death respectively. Moreover, none of the extracts had shown cytotoxic effect while evaluated against normal non-cancerous cell lines (MCF- 10A). Conclusions: It is inferred from the current findings that phytoconstituents present in the plant extracts have high anticancer potential. These phytoconstituents along with some new anticancer agents present in the plant extracts reflects the high cytotoxic potential against cancer cells.
{"title":"Antitumor and cytotoxic potential of various extracts of Gloriosa superba L. Centaurea behen L., Elaeocarpus ganitrus Roxb and Ficus religiosa L. against human breast cancer (MDA-MB 231) cell lines","authors":"Satnam Singh, Amandeep Saini, R. G. Saini","doi":"10.18203/2320-6012.ijrms20233982","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233982","url":null,"abstract":"Background: Medicinal plants are rich in a wide variety of secondary metabolites such as tannins, alkaloids, phenolic compounds, flavonoids etc. which have the capability to inhibit many pathways that lead to cancer. The present study was conducted with the objectives to screen the extracts of dried roots Gloriosa superba L., dried roots of Centaurea behen L. dried fruits/beads of Elaeocarpus ganitrus Roxb., dried leaves of Ficus religiosa L. and investigate their antitumor activity on human breast cancer cell lines (MDA-MB 231). Methods: Cytotoxic activity was evaluated against non-cancerous cell lines (MCF-10A). Hexane, chloroform, methanol and water were the solvents used for extraction of phytoconstituents by Soxhlet method. Anti-proliferative potential of the plant extracts was evaluated using MTT assay. The trypan blue dye exclusion test was used to determine the number of viable cells present in a cell suspension. Results: On MDA MB-231 cell lines, 91.94% cell death was reported with G. superba aqueous extract followed by E. ganitrus methanol extract and F. religiosa hexane extract with 87.93% and 81.61% cell death respectively. Moreover, none of the extracts had shown cytotoxic effect while evaluated against normal non-cancerous cell lines (MCF- 10A). Conclusions: It is inferred from the current findings that phytoconstituents present in the plant extracts have high anticancer potential. These phytoconstituents along with some new anticancer agents present in the plant extracts reflects the high cytotoxic potential against cancer cells.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"209 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20233992
M. Mulani, Savita Deshmukh, Shrikant W. Masaram, Dilip Bhave
Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by incomplete reversible airflow limitation, which is associated with emphysema and chronic inflammation. Oxidative/antioxidant imbalance is one of the mechanisms of the current pathogenesis of COPD ECSOD is an antioxidant protein that scavenges superoxide free radicals from cigarette smoke and protects the lungs from free radical damage and chronic inflammation. Methods: Vitamin C was estimated by acid phosphotungustate on spectrometer at 660nm (Ayekygw 1978) method. SOD was estimated by Marklund S and Marklund G (1974) modified by Nandi and Chatterjee. FEV1/FEV ratio was done by spirometry technique. Results: The present study revealed that there was an increased oxidative stress in patients with COPD, when compared with controls and also decreased level of antioxidant activity in COPD patients, when compared with controls. In our studies significantly decreased sr. superoxide dismutase activity and FEV1/FVC ratio levels were found in subjects with COPD than healthy normal subjects. Conclusions: A significant decline in lung function may be associated with altered antioxidant enzyme activity due to the strong correlation between SOD and lung functions with COPD severity.
{"title":"A study of vitamin C, superoxide dismutase and FEV1/FVC ratio in chronic obstructive pulmonary disease","authors":"M. Mulani, Savita Deshmukh, Shrikant W. Masaram, Dilip Bhave","doi":"10.18203/2320-6012.ijrms20233992","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233992","url":null,"abstract":"Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by incomplete reversible airflow limitation, which is associated with emphysema and chronic inflammation. Oxidative/antioxidant imbalance is one of the mechanisms of the current pathogenesis of COPD ECSOD is an antioxidant protein that scavenges superoxide free radicals from cigarette smoke and protects the lungs from free radical damage and chronic inflammation. Methods: Vitamin C was estimated by acid phosphotungustate on spectrometer at 660nm (Ayekygw 1978) method. SOD was estimated by Marklund S and Marklund G (1974) modified by Nandi and Chatterjee. FEV1/FEV ratio was done by spirometry technique. Results: The present study revealed that there was an increased oxidative stress in patients with COPD, when compared with controls and also decreased level of antioxidant activity in COPD patients, when compared with controls. In our studies significantly decreased sr. superoxide dismutase activity and FEV1/FVC ratio levels were found in subjects with COPD than healthy normal subjects. Conclusions: A significant decline in lung function may be associated with altered antioxidant enzyme activity due to the strong correlation between SOD and lung functions with COPD severity.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"15 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20233986
R. Chetambath, Rayees A. Kathim, Ramseena Ibrahim
Background: This prospective study investigated if alpha-1-antitrypsin (AAT) levels could predict chronic obstructive pulmonary disease (COPD) exacerbations needing hospitalization. Methods: 106 COPD subjects hospitalized for acute exacerbations were enrolled. Past 2-years’ records were evaluated for prior exacerbation hospitalizations. AAT levels and post-stabilization FEV1 were assessed during current hospitalization. Exacerbation frequency correlated to current AAT levels and lung function. Results: Significant inverse association found between AAT levels and hospitalized exacerbations, indicating utility as a predictive biomarker for COPD patients prone to recurrent severe flares requiring admission. Patients with lower AAT levels also exhibited poorer lung function per lower FEV1 values. Conclusions: Monitoring AAT levels may promote timely interventions in high risk individuals susceptible to relapsing catastrophic exacerbations needing inpatient care. Further research warranted to validate findings and explore if supplementing deficient AAT reduces exacerbation frequency, thereby improving prognosis in this debilitating disease.
{"title":"Alpha-1-antitrypsin level as a predictor of acute exacerbations in chronic obstructive pulmonary disease: a prospective observational study","authors":"R. Chetambath, Rayees A. Kathim, Ramseena Ibrahim","doi":"10.18203/2320-6012.ijrms20233986","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233986","url":null,"abstract":"Background: This prospective study investigated if alpha-1-antitrypsin (AAT) levels could predict chronic obstructive pulmonary disease (COPD) exacerbations needing hospitalization. Methods: 106 COPD subjects hospitalized for acute exacerbations were enrolled. Past 2-years’ records were evaluated for prior exacerbation hospitalizations. AAT levels and post-stabilization FEV1 were assessed during current hospitalization. Exacerbation frequency correlated to current AAT levels and lung function. Results: Significant inverse association found between AAT levels and hospitalized exacerbations, indicating utility as a predictive biomarker for COPD patients prone to recurrent severe flares requiring admission. Patients with lower AAT levels also exhibited poorer lung function per lower FEV1 values. Conclusions: Monitoring AAT levels may promote timely interventions in high risk individuals susceptible to relapsing catastrophic exacerbations needing inpatient care. Further research warranted to validate findings and explore if supplementing deficient AAT reduces exacerbation frequency, thereby improving prognosis in this debilitating disease.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"14 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20234027
Aisha R. Siddiqui, Hari C. Kistipati, Fatema A. Asghar, Sameer Bhimani, Muhammad T. Habib, F. F. Siddiqui, Mariam Anwar, Muhammad H. Gul, Hassan Ali Hassan Ali, Muhammad M. A. Khan
Cancer is a significant healthcare problem. However, advancements in diagnostic procedures and therapeutic modalities have led to a decline in cancer mortality rates by 1% annually in most countries. Cancer patients often experience symptoms such as pain, cancer-related fatigue, anxiety, and lymphedema. To counter these side effects, there have been tremendous efforts. One such effort is the use of virtual reality (VR) technology, which is an interactive technology. VR has played a significant role in managing disorders such as phobias and anxiety disorders, and support for patients with cognitive and physical rehabilitation, acute and chronic pain management, and emotional support in different settings such as during hospitalizations. Our team conducted an extensive search for electronic literature on virtual reality in various databases, such as Medline, PubMed, Google Scholar, and Psych INFO, up to July 2023. We used keywords like "virtual reality," "cancer care," "depression," "cognition," "pain," "telemedicine," "rehabilitation care," "physical therapy," "radiotherapy," "telerehabilitation," "avatar," "video games," and "visual aid" as our search criteria. VR interventions for cancer patients include exposure therapy, psycho-education, and relaxation techniques, which have been shown to reduce symptoms significantly. VR distraction can also mitigate pain during medical procedures. Studies suggest that VR holds promise in rehabilitation and oncologic treatment, as it can improve function metrics, range of motion, and motivation for treatment. The review scrutinizes the use of digital information and virtual reality technology to alleviate cancer-related distress by providing remote care.
{"title":"Immersive horizons: navigating ethical terrain and practical boundaries in the use of virtual reality for cancer symptom management – a comprehensive narrative review","authors":"Aisha R. Siddiqui, Hari C. Kistipati, Fatema A. Asghar, Sameer Bhimani, Muhammad T. Habib, F. F. Siddiqui, Mariam Anwar, Muhammad H. Gul, Hassan Ali Hassan Ali, Muhammad M. A. Khan","doi":"10.18203/2320-6012.ijrms20234027","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20234027","url":null,"abstract":"Cancer is a significant healthcare problem. However, advancements in diagnostic procedures and therapeutic modalities have led to a decline in cancer mortality rates by 1% annually in most countries. Cancer patients often experience symptoms such as pain, cancer-related fatigue, anxiety, and lymphedema. To counter these side effects, there have been tremendous efforts. One such effort is the use of virtual reality (VR) technology, which is an interactive technology. VR has played a significant role in managing disorders such as phobias and anxiety disorders, and support for patients with cognitive and physical rehabilitation, acute and chronic pain management, and emotional support in different settings such as during hospitalizations. Our team conducted an extensive search for electronic literature on virtual reality in various databases, such as Medline, PubMed, Google Scholar, and Psych INFO, up to July 2023. We used keywords like \"virtual reality,\" \"cancer care,\" \"depression,\" \"cognition,\" \"pain,\" \"telemedicine,\" \"rehabilitation care,\" \"physical therapy,\" \"radiotherapy,\" \"telerehabilitation,\" \"avatar,\" \"video games,\" and \"visual aid\" as our search criteria. VR interventions for cancer patients include exposure therapy, psycho-education, and relaxation techniques, which have been shown to reduce symptoms significantly. VR distraction can also mitigate pain during medical procedures. Studies suggest that VR holds promise in rehabilitation and oncologic treatment, as it can improve function metrics, range of motion, and motivation for treatment. The review scrutinizes the use of digital information and virtual reality technology to alleviate cancer-related distress by providing remote care.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"59 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20233999
D. Bhandary, Rachan Amin, Ranjith Shetty
Background: Hernia is defined as abnormal protrusion of whole or a part of a viscus through the wall that contains it. Among all external abdominal hernias, inguinal hernia is one most typically encountered. Many factors are responsible for the formation of hernia. We intended to study the risk of inguinal hernia in low lying pubic tubercle. Methods: The study was conducted on patients in AJIMS, India. It is a case-control study with 80 cases and 80 control meeting inclusion criteria, in all patients, following parameters SS line, ST line, height, weight was recorded and evaluated. Results: The average SS value for case which was much above the average in control.ST value was higher case group than control group, and p<0.0001 which was significant. when it comes to the mean of (SS/ST ratio)/height was higher in the case group than control group. Results developed show majority of the subjects with a low-lying pubic tubercle were inguinal hernia patients. Conclusions: Based on my study, interspinal distance (SS line) and pubo-spinal distance (ST line) are more in cases compared to control. Configuration of bony pelvis seems to be a major contributing factor in determining the risk of development of inguinal hernia as evidenced by the variations in ST length. This low-lying pubic tubercle is very important before selecting the patient for any surgical correction. So, the proper demonstration of anatomy of inguinal region is very important before selecting the surgical technique.
背景：疝气是指内脏的全部或部分异常突出于内脏壁。在所有腹外疝中，腹股沟疝是最常见的一种。疝气的形成有很多因素。我们旨在研究低位耻骨结节发生腹股沟疝的风险。研究方法研究对象为印度 AJIMS 的患者。这是一项病例对照研究，80 例病例和 80 例对照符合纳入标准，对所有患者的 SS 线、ST 线、身高、体重等参数进行了记录和评估。研究结果病例组的平均 SS 值远高于对照组。病例组的 ST 值高于对照组，P<0.0001，差异显著。研究结果表明，大多数耻骨结节低平的受试者都是腹股沟疝患者。结论：根据我的研究，与对照组相比，病例组的脊柱间距（SS 线）和耻骨脊柱间距（ST 线）更大。骨盆的构造似乎是决定腹股沟疝发病风险的一个主要因素，这一点从 ST 线长度的变化中可以看出。在选择患者进行任何手术矫正之前，耻骨结节的低位非常重要。因此，在选择手术方法之前，正确展示腹股沟区域的解剖结构非常重要。
{"title":"Role of height of an individual and low lying pubic tubercle as risk factors of inguinal hernia: case controlled study","authors":"D. Bhandary, Rachan Amin, Ranjith Shetty","doi":"10.18203/2320-6012.ijrms20233999","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233999","url":null,"abstract":"Background: Hernia is defined as abnormal protrusion of whole or a part of a viscus through the wall that contains it. Among all external abdominal hernias, inguinal hernia is one most typically encountered. Many factors are responsible for the formation of hernia. We intended to study the risk of inguinal hernia in low lying pubic tubercle. Methods: The study was conducted on patients in AJIMS, India. It is a case-control study with 80 cases and 80 control meeting inclusion criteria, in all patients, following parameters SS line, ST line, height, weight was recorded and evaluated. Results: The average SS value for case which was much above the average in control.ST value was higher case group than control group, and p<0.0001 which was significant. when it comes to the mean of (SS/ST ratio)/height was higher in the case group than control group. Results developed show majority of the subjects with a low-lying pubic tubercle were inguinal hernia patients. Conclusions: Based on my study, interspinal distance (SS line) and pubo-spinal distance (ST line) are more in cases compared to control. Configuration of bony pelvis seems to be a major contributing factor in determining the risk of development of inguinal hernia as evidenced by the variations in ST length. This low-lying pubic tubercle is very important before selecting the patient for any surgical correction. So, the proper demonstration of anatomy of inguinal region is very important before selecting the surgical technique.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"22 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20233984
Soumyakanti Das, A. T. E. Raj, Y. K. Jebasingh, B. Kannan, Hrishikesh S. Pai
Background: Ischemic stroke is a top contributor to mortality amongst non-infectious diseases. Atherosclerosis is a major risk factor. This study aims to assess LDL levels and ejection fraction in ischemic stroke patients. Methods: This descriptive cross-sectional study was conducted in Government Thoothukudi Medical College from November, 2022 to April, 2023. 35 patients admitted in the neuromedicine ward and diagnosed as acute ischemic stroke were included in the study after informed consent and ethical clearance. Patients with acute neurological deficit and evidence of infarct on diffusion-weighted MRI were included. Patients with no evidence of infarct on DWI, those already on lipid lowering therapy, patients with a history of cerebrovascular disease or transient ischemic attacks were excluded. Blood for lipid profile taken after 8 hours of overnight fasting. Echocardiography done for all patients. Results: Of the 35 patients, 26 (74.28%) were men, mean age was 62.4. 57.14% ischemic stroke patients had their LDL levels elevated, 28.57% had decreased HDL, 28.57% had total cholesterol levels elevated, and in 14.28% triglycerides was elevated. This study also observed the cardiac status of the patients which showed 29% patients had decreased ejection fraction. Conclusions: This study concluded that most patients had elevated LDL levels which is an independent risk factor of ischemic cerebrovascular disease. LDL levels were also associated with decreased ejection fraction in a significant number of patients. Thereby it can be concluded that elevated LDL cholesterol levels can add to the cardiac risk, potentially contributing to stroke morbidity and mortality.
{"title":"LDL levels and ejection fraction in ischemic stroke patients: a hospital based cross-sectional study","authors":"Soumyakanti Das, A. T. E. Raj, Y. K. Jebasingh, B. Kannan, Hrishikesh S. Pai","doi":"10.18203/2320-6012.ijrms20233984","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233984","url":null,"abstract":"Background: Ischemic stroke is a top contributor to mortality amongst non-infectious diseases. Atherosclerosis is a major risk factor. This study aims to assess LDL levels and ejection fraction in ischemic stroke patients. Methods: This descriptive cross-sectional study was conducted in Government Thoothukudi Medical College from November, 2022 to April, 2023. 35 patients admitted in the neuromedicine ward and diagnosed as acute ischemic stroke were included in the study after informed consent and ethical clearance. Patients with acute neurological deficit and evidence of infarct on diffusion-weighted MRI were included. Patients with no evidence of infarct on DWI, those already on lipid lowering therapy, patients with a history of cerebrovascular disease or transient ischemic attacks were excluded. Blood for lipid profile taken after 8 hours of overnight fasting. Echocardiography done for all patients. Results: Of the 35 patients, 26 (74.28%) were men, mean age was 62.4. 57.14% ischemic stroke patients had their LDL levels elevated, 28.57% had decreased HDL, 28.57% had total cholesterol levels elevated, and in 14.28% triglycerides was elevated. This study also observed the cardiac status of the patients which showed 29% patients had decreased ejection fraction. Conclusions: This study concluded that most patients had elevated LDL levels which is an independent risk factor of ischemic cerebrovascular disease. LDL levels were also associated with decreased ejection fraction in a significant number of patients. Thereby it can be concluded that elevated LDL cholesterol levels can add to the cardiac risk, potentially contributing to stroke morbidity and mortality.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"1 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-28DOI: 10.18203/2320-6012.ijrms20233998
Sumera Imran, Imran Sabir, R. Mandole, Sadik Khan
Background: The current study sought to assess restoration of carbohydrate metabolism in known type 2 diabetes patients to achieve good glycemic control without dependency on oral antihyperglycemic agents by implementing the comprehensive diabetes control (CDC) program. Methods: A retrospective, single-centre observational study was conducted from April 2021 to April 2022. Patients who were known cases of type 2 diabetes mellitus aged 18 years and above who underwent at least 6 sessions of the CDC program were included in this study. Patients with type 1 diabetes mellitus were excluded from the study. Follow-up was conducted after 90 days. Baseline data was compared with follow-up data. Results: A total of 69 patients were assessed in this study. Of the patients, testing was performed on 95.8% patients, of which. 92.8% patients were found to have negative glucose tolerance and 7.3% were found to have impaired glucose tolerance. Conclusions: The CDC program can be useful to restore euglycemia in know type 2 diabetic patients by reducing insulin resistance caused by central obesity.
{"title":"Role of ayurveda detoxification and dietary modification on restoration of euglycemia in T2DM patients","authors":"Sumera Imran, Imran Sabir, R. Mandole, Sadik Khan","doi":"10.18203/2320-6012.ijrms20233998","DOIUrl":"https://doi.org/10.18203/2320-6012.ijrms20233998","url":null,"abstract":"Background: The current study sought to assess restoration of carbohydrate metabolism in known type 2 diabetes patients to achieve good glycemic control without dependency on oral antihyperglycemic agents by implementing the comprehensive diabetes control (CDC) program. Methods: A retrospective, single-centre observational study was conducted from April 2021 to April 2022. Patients who were known cases of type 2 diabetes mellitus aged 18 years and above who underwent at least 6 sessions of the CDC program were included in this study. Patients with type 1 diabetes mellitus were excluded from the study. Follow-up was conducted after 90 days. Baseline data was compared with follow-up data. Results: A total of 69 patients were assessed in this study. Of the patients, testing was performed on 95.8% patients, of which. 92.8% patients were found to have negative glucose tolerance and 7.3% were found to have impaired glucose tolerance. Conclusions: The CDC program can be useful to restore euglycemia in know type 2 diabetic patients by reducing insulin resistance caused by central obesity.","PeriodicalId":505944,"journal":{"name":"International Journal of Research in Medical Sciences","volume":"31 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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