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The appropriateness of the director's compensation and the breach of the director' duty of loyalty 董事薪酬的适当性与董事忠诚义务的违背
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-12-31 DOI: 10.36894/KCCA.2020.33.4.189
Jae-bum Kim
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引用次数: 0
Obligation to pay insurance benefit for medical expenses in hospitals established by non-medical personnel 非医务人员设立的医院医疗费用保险给付义务
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-12-31 DOI: 10.36894/KCCA.2020.33.4.107
S. Lim
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引用次数: 0
Article 69 of the Commercial Act and Liability for incomplete performance 商法第六十九条与履行不完全责任
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-12-31 DOI: 10.36894/kcca.2020.33.4.151
Gang-hyeon An 
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引用次数: 0
Midline Destructive Syndrome in a Patient with HIV, Case Report, Review and Approach Proposal 1例HIV患者的中线破坏综合征,病例报告,回顾和方法建议
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-12-27 DOI: 10.46527/2582-5038.177
Salgado E, Gamas A, P. B, F. G., R. R, Valverde A
Midline Destructive Syndrome (MDS) was first-described in 1897 [1]. It was not until 1922 when Stewart reported 10 cases of a chronic destructive process in the facial midline. Since then, there have been multiple ways to call the syndrome, including idiopathic midline granuloma, lethal midline granuloma, polymorphic reticulosis, and Stewart's syndrome, among others. This reflects the variability behavior and the lack of homogeneous nomenclature [2]. Abstract
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引用次数: 0
MRU Imaging after Infection of Furosemide for the Accuracy Diagnosis of Symptomatic Hydronephrosis 速尿感染后MRU成像对症状性肾积水的准确诊断
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-12-09 DOI: 10.46527/2582-5038.174
X. Jia, Chen Zhongyu, C. Guangjie
Objectives: To explore the feasibility of MRU (Magnetic Resonance Urography) under the intravenous injection of furosemide (FRS) in the diagnosis of abnormal hydronephrosis caused by renal pelvis and ureteral junctions during the intermittent period, though a 1.5T magnetic resonance scanner. Study Design: Clinical research. Place and Duration of Study: Department of Radiology and Urology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China, from April to September 2019. Methods: Twenty-four children, with symptomatic hydronephrosis caused by abnormal pelvic ureteral junctions during the intermittent period, were scanned by MRU after the first static hydration and the second intravenous injection of FRS, and contrast with ultrasound (US) results. Then comparison with the pathological results for who undergoing surgical treatment. The US and MRU image development was evaluated on a 4-point scale for renal pelvis and ureter development, and the overall situation was evaluated on a 5-point scale. Results: BUS had 70.8% sensitivity of hydronephrosis, 16.7% sensitivity of ureteral dilatation, and overall sensitivity of 70.8%. The sensitivity of the three indexes in the hydraulic group was 87.5%, 95.8% and 100%, respectively. For the FRS group, the sensitivity increased to 100%, and when comparison with the pathological results from the 13 out of 24 cases underwent surgical treatment, the positive rate of coincidence was 77%. www.yumedtext.com | December-2020 | ISSN: 2582-5038 | https://dx.doi.org/10.46527/2582-5038.174
目的:探讨静脉注射呋塞米(FRS)的MRU(磁共振尿路造影)在1.5T磁共振扫描仪上诊断间歇期肾盂输尿管交界处异常积水的可行性。研究设计:临床研究。学习地点和时间:浙江大学医学院儿童医院放射泌尿科,2019年4月至9月,中国杭州。方法:对24例间歇性肾盂输尿管连接异常引起的症状性肾积水患儿,在第一次静注和第二次静脉注射FRS后进行MRU扫描,并与超声结果进行对比。然后与接受手术治疗的患者的病理结果进行比较。肾盂和输尿管发育的超声和核磁共振成像发展以4分制评估,总体情况以5分制评估。结果:BUS对肾积水的敏感性为70.8%,对输尿管扩张的敏感性为16.7%,总体敏感性为70.8%.液压组三项指标的敏感性分别为87.5%、95.8%和100%。FRS组的敏感性增加到100%,与24例接受手术治疗的病例中的13例的病理结果相比,阳性符合率为77%。www.yumedtext.com | 2020年12月| ISSN:2582-5038|https://dx.doi.org/10.46527/2582-5038.174
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引用次数: 0
Lunotriquetral Coalition: Report of Two Different Cases Lunotriquitral联盟:两例不同病例的报告
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-12-08 DOI: 10.46527/2582-5038.173
M. Bayati, Thena J Al Khishali, Mohanad Ma Al Bayati, Hameed Bm
Lunotriquetral coalition (LTC) is fusion of the lunate and triquetral bones of the carpus. LTC is most common accounting 90%, of all coalitions in the hand frequently bilateral, in unilateral cases mostly on the left side [1,2]. It can be between any carpal or metacarpal bones, but mostly in one row on the ulnar side. Incidence is 0.1% in Caucasian population, more in females with 2: 1 ratio. Incidence is higher in Africans, mostly in West African tribes up to 9%, 1 [3-5]. It is hereditary, dominant, autosomal linked condition of failure of cavitation of wrist cartilage, occur in the 4-8 months of gestational period. Coalition can be fibrous, cartilaginous, or osseous, complete, or partial. It appears on radiograph in early adulthood, from 6-14 years, with ossification of carpal bones. Abstract
新月体-腕骨联盟(LTC)是腕骨的月骨和三角骨的融合。LTC最常见,占手部所有联盟的90%,通常是双侧的,在单侧的情况下主要在左侧[1,2]。它可以在任何腕骨或掌骨之间,但大多在尺侧的一排。高加索人群的发病率为0.1%,女性发病率为2:1。非洲人的发病率更高,主要在西非部落,高达9%,1[3-5]。这是一种遗传性、显性、常染色体连锁的手腕软骨空化失败的情况,发生在妊娠期的4-8个月。联盟可以是纤维状、软骨状或骨状、完全性或部分性。它出现在6-14岁成年早期的X线片上,伴有腕骨骨化。摘要
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引用次数: 0
Anticoagulation in Pregnancy and Post-partum: New Options 妊娠期和产后抗凝:新的选择
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-12-06 DOI: 10.46527/2582-5038.172
S. Rajan, Aparna K Sharma
The ideal anticoagulant in pregnancy and postpartum is yet to be found. Vitamin K antagonists are cumbersome to use having multiple interactions with food and other drugs, requiring frequent laboratory monitoring and necessitating switch over to heparin in early pregnancy and around delivery. Direct Oral Anticoagulants (DOAC) are now therapeutic alternatives to Warfarin in the management of venous thromboembolism, non-valvular atrial fibrillation, and acute coronary syndromes. Their use in pregnancy and the postpartum period is to be explored. Our case is a 35-year, third gravida with two living issues with Rheumatic heart disease (severe mitral and tricuspid regurgitation, moderate pulmonary artery hypertension and chronic atrial fibrillation). She presented at 18 weeks’ gestation with active bleeding from a low-lying placenta. This being an unwanted pregnancy, she underwent hysterotomy with bilateral tubal ligation. Post procedure, warfarin was initiated in view of her chronic atrial fibrillation, and slowly titrated to a target an INR of 2-3. She developed spontaneous haemoperitoneum on warfarin therapy, which was conservatively managed. After resolution of haemoperitoneum, attempting to establish adequate anticoagulation on heparin and warfarin prolonged her hospital stay by an additional 3 weeks of hospital stay until dabigatran was initiated and the patient could be discharged. DOACs offer several advantages efficacy, safety, predictable pharmacokinetics. Although category C drugs in pregnancy, as data accumulates on exposures of these drugs in pregnancy, they may be a future therapeutic option which avoids many of the problems associated with current anticoagulation regimes.
妊娠期和产后理想的抗凝剂尚未找到。维生素K拮抗剂使用起来很麻烦,与食物和其他药物有多种相互作用,需要频繁的实验室监测,并且必须在妊娠早期和分娩前后改用肝素。直接口服抗凝剂(DOAC)现在是华法林治疗静脉血栓栓塞、非瓣膜性心房颤动和急性冠状动脉综合征的替代品。它们在怀孕和产后的使用有待探索。我们的病例是一名35岁的第三位孕妇,患有两种类风湿性心脏病(严重的二尖瓣和三尖瓣反流、中度肺动脉高压和慢性心房颤动)。她在妊娠18周时表现为低位胎盘活动性出血。由于意外怀孕,她接受了子宫切除术和双侧输卵管结扎术。术后,考虑到她的慢性心房颤动,开始使用华法林,并缓慢滴定至目标INR为2-3。她在接受华法林治疗后出现自发性腹膜出血,这是保守治疗。腹膜透析后,试图对肝素和华法林进行足够的抗凝治疗,将她的住院时间延长了3周,直到达比加群开始使用,患者可以出院。DOAC具有疗效、安全性和可预测的药代动力学等优点。尽管妊娠期使用C类药物,但随着妊娠期使用这些药物的数据积累,它们可能是未来的治疗选择,可以避免与当前抗凝制度相关的许多问题。
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引用次数: 0
Atypical Teratoid/Rhabdoid Tumor in Adults an Uncommon Entity: A Case Report 成人不典型畸胎瘤/横纹肌样肿瘤一例报告
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-11-30 DOI: 10.46527/2582-5038.171
Neeraj Salhotra, S. Laiq, C. Livingston, Mahmood Al Hattali, Hunaina Al Kindi, Zahra Al Hajri
Atypical teratoid/rhabdoid (AT/RT) tumor is a rare, highly malignant tumor of the central nervous system (CNS), most commonly found in children less than 5 years of age. Although the vast majority of cases are diagnosed in young children, there have been isolated case reports in adults. Since its histological appearance can be confused with other tumors, especially in adults, separating AT/RT from other neoplasms may be difficult. In many instances, a reliable diagnosis is not possible without demonstrating the lack of nuclear INI1 (SMARCB1) or BRG1 (SMARCA4) protein expression by immunohistochemical methods or by detection of somatic / germline mutation of the INI1 (SMARCB1) or BRG1 (SMARCA4) gene. Final diagnosis is confirmed after immunohistochemical analysis and/or molecular analysis. Immunohistochemical staining show that the tumor cells are positive for vimentin and reacted variably for keratin, epithelial membrane antigen (EMA), synaptophysin, neurofilament protein, CD34, and smooth muscle actin (SMA) and negative for GFAP, S-100, desmin and CD99. In adult examples of AT/RT, the diagnosis requires a high index of suspicion, with early tissue diagnosis and a low threshold for investigation with INI1 immunohistochemistry to differentiate this entity from other morphologically similar tumors. Although Abstract
非典型畸胎体/横纹肌样(AT/RT)肿瘤是一种罕见的中枢神经系统高度恶性肿瘤,最常见于5岁以下儿童。虽然绝大多数病例是在幼儿中诊断出来的,但在成人中也有孤立的病例报告。由于其组织学表现可能与其他肿瘤混淆,特别是在成人中,因此很难将AT/RT与其他肿瘤区分开来。在许多情况下,如果不通过免疫组织化学方法或检测INI1 (SMARCB1)或BRG1 (SMARCA4)基因的体细胞/种系突变来证明核INI1 (SMARCB1)或BRG1 (SMARCA4)蛋白表达缺乏,则不可能进行可靠的诊断。最终诊断需要经过免疫组织化学分析和/或分子分析。免疫组化染色显示肿瘤细胞波形蛋白呈阳性,角蛋白、上皮膜抗原(EMA)、突触素、神经丝蛋白、CD34、平滑肌肌动蛋白(SMA)呈阳性,GFAP、S-100、desmin、CD99呈阴性。在成人AT/RT病例中,诊断需要高怀疑指数,早期组织诊断和INI1免疫组织化学调查的低阈值,以区分该实体与其他形态相似的肿瘤。虽然抽象
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引用次数: 1
Hairy Cell Leukemia Related Osteolyses Detected by PET Successfully Treated with Cladribine and Ibandronate 氯德里滨联合依班膦酸盐成功治疗毛细胞白血病相关骨溶解
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-11-28 DOI: 10.46527/2582-5038.170
E. Ranković, A. Balenović, S. Dotlic, I. Aurer
Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disorder clinically characterized by pancytopenia and splenomegaly [1], with high overall survival rates after treatment with purine analogues [2-4]. We report a relatively young patient with HCL presenting with widespread osteolytic disease detected by PET who was successfully treated with cladribine and ibandronate. Osteolyses are not considered a frequent complication of HCL [5] and we are aware of only one case report describing the use of PET for diagnostic purposes in this setting [6]. Resolution of bone lesions has been described after treatment with radiotherapy or cladribine [6-9], but to our knowledge, there are no data on the use of bisphosphonates in this context.
毛细胞白血病(HCL)是一种罕见的惰性淋巴增生性疾病,临床特征为全血细胞减少症和脾肿大[1],嘌呤类似物治疗后总生存率高[2-4]。我们报告了一名相对年轻的HCL患者,其PET检测到广泛的溶骨性疾病,并成功地用克拉屈滨和伊班膦酸盐治疗。溶骨细胞不被认为是HCL的常见并发症[5],据我们所知,只有一份病例报告描述了在这种情况下使用PET进行诊断[6]。已经描述了在放疗或克拉屈滨治疗后骨损伤的解决[6-9],但据我们所知,没有关于在这种情况下使用双磷酸盐的数据。
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引用次数: 0
Digital contact tracing 数字接触追踪
IF 2.8 4区 计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS Pub Date : 2020-10-26 DOI: 10.1145/3431832.3431841
Amee Trivedi, Deepak Vasisht
Since the start of the COVID-19 pandemic, technology enthusiasts have pushed for digital contact tracing as a critical tool for breaking the COVID-19 transmission chains. Motivated by this push, many countries and companies have created apps that enable digital contact tracing with the goal to identify the chain of transmission from an infected individual to others and enable early quarantine. Digital contact tracing applications like AarogyaSetu in India, TraceTogether in Singapore, SwissCovid in Switzerland, and others have been downloaded hundreds of millions of times. Yet, this technology hasn't seen the impact that we envisioned at the start of the pandemic. Some countries have rolled back their apps, while others have seen low adoption [12, 17]. Therefore, it is prudent to ask what the technology landscape of contact-tracing looks like and what are the missing pieces. We attempt to undertake this task in this paper. We present a high-level review of technologies underlying digital contact tracing, a set of metrics that are important while evaluating different contact tracing technologies, and evaluate where the different technologies stand today on this set of metrics. Our hope is two fold: (a) Future designers of contact tracing applications can use this review paper to understand the technology landscape, and (b) Researchers can identify and solve the missing pieces of this puzzle, so that we are ready to face the rest of the COVID-19 pandemic and any future pandemics. A majority of this discussion is focused on the ability to identify contact between individuals. The questions of ethics, privacy, and security of such contact tracing are briefly mentioned but not discussed in detail.
自2019冠状病毒病大流行开始以来,技术爱好者一直在推动数字接触者追踪,将其作为打破COVID-19传播链的关键工具。在这一推动力的推动下,许多国家和公司开发了能够进行数字接触者追踪的应用程序,目的是确定感染者与他人之间的传播链,并实现早期隔离。印度的AarogyaSetu、新加坡的TraceTogether、瑞士的SwissCovid等数字接触追踪应用程序已经被下载了数亿次。然而,这项技术还没有看到我们在大流行开始时所设想的影响。一些国家已经撤回了他们的应用程序,而另一些国家的应用程序使用率很低[12,17]。因此,谨慎的做法是询问接触追踪的技术前景是什么样的,以及缺失的部分是什么。本文试图承担这一任务。我们对数字接触追踪技术进行了高层次的回顾,这是一组在评估不同接触追踪技术时很重要的指标,并评估了不同技术在这组指标上的地位。我们的希望有两个方面:(a)接触者追踪应用程序的未来设计者可以使用这篇综述论文来了解技术前景;(b)研究人员可以确定并解决这一难题中缺失的部分,以便我们准备好面对COVID-19大流行的其余部分和未来的任何大流行。讨论的重点是识别个体之间联系的能力。这种接触者追踪的伦理、隐私和安全问题被简要地提到,但没有详细讨论。
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引用次数: 26
期刊
ACM Sigcomm Computer Communication Review
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