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Level of structural integration in people with schizophrenia and schizoaffective disorders - applicability and associations with clinical parameters 精神分裂症和分裂情感性障碍患者的结构整合水平--适用性及其与临床参数的关系
Pub Date : 2024-06-06 DOI: 10.3389/fpsyt.2024.1388478
Samuel Bayer, A. Bröcker, Frauke Stuke, S. Just, Gianna Bertram, Imke Grimm, Eva Maaßen, Marielle Büttner, Andreas Heinz, Felix Bermpohl, G. Lempa, D. von Haebler, Christiane Montag
The psychic structure of people with psychosis has been the subject of theoretical and qualitative considerations. However, it has not been sufficiently studied quantitatively. Therefore, the aim of this study was to explore the structural abilities of people diagnosed with schizophrenia and schizoaffective psychosis using the Levels of Structural Integration Axis of the Operationalized Psychodynamic Diagnosis System (OPD-2-LSIA). The study aimed to determine possible associations between the OPD-2-LSIA and central parameters of illness. Additionally, possible structural differences between people diagnosed with schizophrenia and schizoaffective psychosis were tested.This cross-sectional study included 129 outpatients with schizophrenia or schizoaffective disorders. Measures of structural integration, symptom load, severity of illness, cognition, and social functioning were obtained. Descriptive statistics were used to analyze the overall structural level and the structural dimensions. Correlation coefficients were computed to measure the associations between OPD-2-LSIA and variables regarding the severity of illness and psychosocial functioning. Regression models were used to measure the influence of illness-related variables on OPD-2-LSIA, and the influence of OPD-2-LSIA on psychosocial functioning. Participants diagnosed with schizophrenia and schizoaffective disorders were examined with regard to possible group differences.The results of the OPD-2-LSIA showed that the overall structural level was between ‘moderate to low’ and ‘low level of structural integration’. Significant correlations were found between OPD-2-LSIA and psychotic symptoms (but not depressive symptoms), as well as between OPD-2-LSIA and psychosocial functioning. It was found that variables related to severity of illness had a significant impact on OPD-2-LSIA, with psychotic, but not depressive symptoms being significant predictors. OPD-2-LSIA was found to predict psychosocial functioning beyond symptoms and cognition. No significant differences were found between participants with schizophrenia and schizoaffective psychosis. There was also no correlation found between OPD-2-LSIA and depressive symptomatology (except for the subdimension Internal communication).Contrary to theoretical assumptions, the results of the study show a heterogenous picture of the psychic structure of people with psychosis. The associations between OPD-2-LSIA and severity of illness, particularly psychotic symptomatology, as well as the influence of OPD-2-LSIA on psychosocial functioning, are discussed.
精神病患者的心理结构一直是理论和定性研究的主题。然而,定量研究还不够充分。因此,本研究的目的是使用操作化心理动力学诊断系统的结构整合轴水平(OPD-2-LSIA)来探索被诊断为精神分裂症和分裂情感性精神病患者的结构能力。研究旨在确定 OPD-2-LSIA 与疾病中心参数之间可能存在的关联。这项横断面研究纳入了 129 名精神分裂症或分裂情感性精神病门诊患者。这项横断面研究纳入了 129 名精神分裂症或分裂情感障碍门诊患者,对他们的结构整合、症状负荷、病情严重程度、认知能力和社会功能进行了测量。描述性统计用于分析整体结构水平和结构维度。计算了相关系数,以衡量 OPD-2-LSIA 与疾病严重程度和社会心理功能变量之间的关联。回归模型用于测量疾病相关变量对 OPD-2-LSIA 的影响,以及 OPD-2-LSIA 对社会心理功能的影响。OPD-2-LSIA的结果显示,总体结构水平介于 "中低 "和 "低结构整合水平 "之间。OPD-2-LSIA 与精神病症状(而非抑郁症状)之间以及 OPD-2-LSIA 与社会心理功能之间存在显著相关性。研究发现,与病情严重程度相关的变量对 OPD-2-LSIA 有显著影响,其中精神病症状而非抑郁症状是重要的预测因素。研究发现,OPD-2-LSIA 对社会心理功能的预测作用超出了症状和认知能力。在精神分裂症和分裂情感性精神病患者之间没有发现明显的差异。OPD-2-LSIA与抑郁症状之间也没有相关性(除了内部交流这个子维度)。本研究讨论了 OPD-2-LSIA 与病情严重程度(尤其是精神病症状)之间的关系,以及 OPD-2-LSIA 对社会心理功能的影响。
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引用次数: 0
Assessing the associations of 1,400 blood metabolites with major depressive disorder: a Mendelian randomization study 评估 1,400 种血液代谢物与重度抑郁障碍的关系:孟德尔随机研究
Pub Date : 2024-06-06 DOI: 10.3389/fpsyt.2024.1391535
Tiantian Dong, Xingxin Wang, Zhixia Jia, Jiguo Yang, Yuanxiang Liu
Major Depressive Disorder (MDD) is one of the most prevalent and debilitating health conditions worldwide. Previous studies have reported a link between metabolic dysregulation and MDD. However, evidence for a causal relationship between blood metabolites and MDD is lacking.Using a two-sample bidirectional Mendelian randomization analysis (MR), we assessed the causal relationship between 1,400 serum metabolites and Major Depressive Disorder (MDD). The Inverse Variance Weighted method (IVW) was employed to estimate the causal association between exposures and outcomes. Additionally, MR-Egger regression, weighted median, simple mode, and weighted mode methods were used as supplementary approaches for a comprehensive appraisal of the causality between blood metabolites and MDD. Pleiotropy and heterogeneity tests were also conducted. Lastly, the relevant metabolites were subjected to metabolite function analysis, and a reverse MR was implemented to explore the potential influence of MDD on these metabolites.After rigorous screening, we identified 34 known metabolites, 13 unknown metabolites, and 18 metabolite ratios associated with Major Depressive Disorder (MDD). Among all metabolites, 33 were found to have positive associations, and 32 had negative associations. The top five metabolites that increased the risk of MDD were the Arachidonate (20:4n6) to linoleate (18:2n6) ratio, LysoPE(18:0/0:0), N-acetyl-beta-alanine levels, Arachidonate (20:4n6) to oleate to vaccenate (18:1) ratio, Glutaminylglutamine, and Threonine to pyruvate ratio. Conversely, the top five metabolites that decreased the risk of MDD were N6-Acetyl-L-lysine, Oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] to linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2] ratio, Methionine to phosphate ratio, Pregnanediol 3-O-glucuronide, and 6-Oxopiperidine-2-carboxylic acid. Metabolite function enrichment was primarily concentrated in pathways such as Bile Acid Biosynthesis (FDR=0.177), Glutathione Metabolism (FDR=0.177), Threonine, and 2-Oxobutanoate Degradation (FDR=0.177). In addition, enrichment was noted in pathways like Valine, Leucine, and Isoleucine Biosynthesis (p=0.04), as well as Ascorbate and Aldarate Metabolism (p=0.04).Within a pool of 1,400 blood metabolites, we identified 34 known metabolites and 13 unknown metabolites, as well as 18 metabolite ratios associated with Major Depressive Disorder (MDD). Additionally, three functionally enriched groups and two metabolic pathways were selected. The integration of genomics and metabolomics has provided significant insights for the screening and prevention of MDD.
重度抑郁症(MDD)是全球最普遍、最令人沮丧的健康问题之一。以前的研究曾报道过代谢失调与 MDD 之间的联系。利用双样本双向孟德尔随机分析法(MR),我们评估了 1400 种血清代谢物与重度抑郁症(MDD)之间的因果关系。我们采用了反方差加权法(IVW)来估计暴露与结果之间的因果关系。此外,还采用了MR-Egger回归法、加权中值法、简单模式法和加权模式法作为补充方法,以全面评估血液代谢物与MDD之间的因果关系。此外,还进行了多向性和异质性检验。最后,我们对相关代谢物进行了代谢物功能分析,并采用反向 MR 方法探讨了 MDD 对这些代谢物的潜在影响。在所有代谢物中,33 种代谢物与 MDD 呈正相关,32 种代谢物与 MDD 呈负相关。增加患重度抑郁症风险的前五种代谢物是花生四烯酸(20:4n6)与亚油酸(18:2n6)的比率、LysoPE(18:0/0:0)、N-乙酰-beta-丙氨酸水平、花生四烯酸(20:4n6)与油酸和疫苗酸(18:1)的比率、谷氨酰胺酰谷氨酰胺和苏氨酸与丙酮酸的比率。相反,降低 MDD 风险的前五种代谢物是 N6-乙酰基-L-赖氨酸、油酰-亚油酰-甘油(18:1 至 18:2) [2] 与亚油酰-丙烯酰-甘油(18:2 至 20:4) [2] 的比率、蛋氨酸与磷酸盐的比率、孕烷二醇 3-O-葡萄糖醛酸和 6-氧代哌啶-2-羧酸。代谢物功能富集主要集中在胆汁酸生物合成(FDR=0.177)、谷胱甘肽代谢(FDR=0.177)、苏氨酸和 2-氧代丁酸降解(FDR=0.177)等途径。此外,缬氨酸、亮氨酸和异亮氨酸的生物合成(P=0.04)以及抗坏血酸和醛酸代谢(P=0.04)等通路也出现了富集。此外,我们还筛选出了三个功能富集组和两条代谢途径。基因组学与代谢组学的结合为MDD的筛查和预防提供了重要启示。
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引用次数: 0
Examining putamen resting-state connectivity markers of suicide attempt history in depressed adolescents 研究抑郁症青少年普塔门静息态连接标记的自杀未遂史
Pub Date : 2024-06-06 DOI: 10.3389/fpsyt.2024.1364271
O. Tymofiyeva, Tiffany C. Ho, Colm G. Connolly, Sasha Gorrell, Ryan Rampersaud, Sabrina M. Darrow, Jeffrey E. Max, Tony T. Yang
Suicide is a current leading cause of death in adolescents and young adults. The neurobiological underpinnings of suicide risk in youth, however, remain unclear and a brain-based model is lacking. In adult samples, current models highlight deficient serotonin release as a potential suicide biomarker, and in particular, involvement of serotonergic dysfunction in relation to the putamen and suicidal behavior. Less is known about associations among striatal regions and relative suicidal risk across development. The current study examined putamen connectivity in depressed adolescents with (AT) and without history of a suicide attempt (NAT), specifically using resting-state functional magnetic resonance imaging (fMRI) to evaluate patterns in resting-state functional connectivity (RSFC). We hypothesized the AT group would exhibit lower striatal RSFC compared to the NAT group, and lower striatal RSFC would associate with greater suicidal ideation severity and/or lethality of attempt.We examined whole-brain RSFC of six putamen regions in 17 adolescents with depression and NAT (MAge [SD] = 16.4[0.3], 41% male) and 13 with AT (MAge [SD] = 16.2[0.3], 31% male).Only the dorsal rostral striatum showed a statistically significant bilateral between-group difference in RSFC with the superior frontal gyrus and supplementary motor area, with higher RSFC in the group without a suicide attempt compared to those with attempt history (voxel-wise p<.001, cluster-wise p<.01). No significant associations were found between any putamen RSFC patterns and suicidal ideation severity or lethality of attempts among those who had attempted.The results align with recent adult literature and have interesting theoretical and clinical implications. A possible interpretation of the results is a mismatch of the serotonin transport to putamen and to the supplementary motor area and the resulting reduced functional connectivity between the two areas in adolescents with attempt history. The obtained results can be used to enhance the diathesis-stress model and the Emotional paiN and social Disconnect (END) model of adolescent suicidality by adding the putamen. We also speculate that connectivity between putamen and the supplementary motor area may in the future be used as a valuable biomarker of treatment efficacy and possibly prediction of treatment outcome.
自杀是目前导致青少年死亡的主要原因之一。然而,青少年自杀风险的神经生物学基础仍不清楚,也缺乏基于大脑的模型。在成人样本中,目前的模型强调血清素释放不足是一种潜在的自杀生物标志物,尤其是血清素能功能障碍与普坦门和自杀行为的关系。人们对纹状体区域与整个发育过程中的相对自杀风险之间的关系知之甚少。本研究通过静息态功能磁共振成像(fMRI)评估静息态功能连通性(RSFC)的模式,对有自杀企图(AT)和无自杀企图(NAT)的抑郁青少年的大脑丘脑连通性进行了研究。我们对 17 名患有抑郁症和 NAT 的青少年(平均年龄 [SD] = 16.4[0.3],41% 为男性)和 13 名患有 AT 的青少年(平均年龄 [SD] = 16.只有背侧喙纹状体与额上回和辅助运动区的 RSFC 显示出具有统计学意义的双侧组间差异,与有自杀未遂史的青少年相比,没有自杀未遂史的青少年的 RSFC 较高(体素方面 p<.001,群组方面 p<.01)。在有自杀企图的人群中,没有发现任何普塔门RSFC模式与自杀意念的严重程度或企图自杀的致命性有明显关联。对这一结果的一种可能解释是,在有自杀未遂史的青少年中,5-羟色胺向大脑丘脑和辅助运动区的转运不匹配,导致这两个区域之间的功能连接性降低。这一结果可用于加强青少年自杀倾向的 "综合-压力模型 "和 "情绪与社会脱节(END)模型"。此外,我们还推测,未来,大脑丘脑和辅助运动区之间的连通性可能会被用作治疗效果的重要生物标志物,并有可能预测治疗结果。
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引用次数: 0
Factors influencing the level of insight and treatment attitude: a cross-sectional study of 141 elderly patients of major depression in Guangzhou, China 影响洞察力水平和治疗态度的因素:对中国广州 141 名老年重度抑郁症患者的横断面研究
Pub Date : 2024-06-05 DOI: 10.3389/fpsyt.2024.1284559
Hang Yang, Jiao Chen, Junrong Ye, Tingwei Zhou, Wen Wang, Yuanxin Pan, Yanheng Wei, Xueling Lu, Lexin Yuan, Shengwei Wu, Jianxiong Guo, Aixiang Xiao
To explore the insight, treatment attitude, and related influencing factors of hospitalized elderly patients suffering from major depression.A total of 141 hospitalized elderly patients with depression were selected as the research objects. Insight was evaluated by the total score of the Insight and Treatment Attitude questionnaire (ITAQ). The data collected included sociodemographic characteristics, psychiatric symptoms, delirium status, social functioning, social support, suicide risk, and cognitive function.The sample included 74.5% of female patients, and the mean age was 67.53 (sd=7.19) years. The influencing factors of inpatients with depression included alcohol consumption, length of hospitalization, admission types, and the main caregivers (P<0.05). The various factors were further analyzed by linear regression, revealing that the insight and treatment attitude of elderly depressed hospitalized patients were mainly related to the Mini-Mental State Examination (MMSE) (β= 0.225, 95% CI 0.055–0.395, P=0.01), dependent on a caregiver (β=-5.810, 95% CI -8.086~-3.535, P<0.001), the type of admission (involuntary admission) (β=-3.365, 95% CI -5.448~-1.283, P=0.002), Functional Activities Questionnaire (FAQ) (β=-0.156, 95% CI -0.303~-0.010, P=0.037), and length of stay (≤28 days) (β=2.272, 95% CI 0.055~-4.489, P=0.045).The level of insight was affected by cognitive function, involuntary admission, dependent on a caregiver, social function and length of stay. Future studies should focus on cognitive function recovery, observation of admission mode, and self-care ability in elderly patients with depression.
目的:探讨住院老年重度抑郁症患者的洞察力、治疗态度及相关影响因素。洞察力通过洞察力和治疗态度问卷(ITAQ)的总分进行评估。收集的数据包括社会人口学特征、精神症状、谵妄状态、社会功能、社会支持、自杀风险和认知功能。住院抑郁症患者的影响因素包括饮酒量、住院时间、入院类型和主要照顾者(P<0.05)。对各种因素进一步进行线性回归分析,发现老年抑郁症住院患者的洞察力和治疗态度主要与小型精神状态检查(MMSE)(β= 0.225,95% CI 0.055-0.395,P=0.01)、依赖照护者(β=-5.810,95% CI -8.086~-3.535,P<0.001)、入院类型(非自愿入院)(β=-3.认知功能、非自愿入院、依赖照护者、社会功能和住院时间对洞察力水平有影响。未来的研究应关注老年抑郁症患者认知功能的恢复、入院方式的观察和自理能力。
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引用次数: 0
Parental depression moderates the relationship between childhood maltreatment and the recognition of children expressions of emotions 父母抑郁可调节儿童受虐待与识别儿童情绪表达之间的关系
Pub Date : 2024-06-05 DOI: 10.3389/fpsyt.2024.1374872
Annie Bérubé, Rachel Pétrin, Caroline Blais
Sensitivity plays a crucial role in parenting as it involves the ability to perceive and respond appropriately to children’s signals. Childhood maltreatment and depression can negatively impact adults’ ability to recognize emotions, but it is unclear which of these factors has a greater impact or how they interact. This knowledge is central to developing efficient, targeted interventions. This paper examines the interaction between parents’ depressive symptoms and childhood maltreatment and its influence on their ability to recognize the five basic emotions (happiness, anger, sadness, fear, and disgust) in children’s faces.The sample consisted of 52 parents. Depressive symptoms were measured by the depression subscale of the Brief Symptom Inventory-18 (BSI-18), and maltreatment history was assessed by the Childhood Trauma Questionnaire (CTQ). Children’s emotional stimuli were morphed images created using The Child Affective Facial Expression (CAFE) database.Our findings indicate that depressive symptoms moderate the relationship between parents’ history of childhood maltreatment and emotion recognition skills. Parents with higher depressive symptoms had lower emotion recognition accuracy when they had not experienced maltreatment. When childhood maltreatment was severe, emotion recognition skills were more consistent across all levels of depression. The relationship between depression and emotion recognition was primarily linked to recognizing sadness in children’s faces.These findings highlight how different experiences can affect parental abilities in emotion recognition and emphasize the need for interventions tailored to individual profiles to improve their effectiveness.
敏感性在养育子女的过程中起着至关重要的作用,因为它涉及到感知和适当回应儿童信号的能力。童年虐待和抑郁症会对成年人识别情绪的能力产生负面影响,但目前还不清楚哪种因素的影响更大,也不清楚它们是如何相互作用的。这些知识对于制定高效、有针对性的干预措施至关重要。本文研究了父母的抑郁症状与童年虐待之间的相互作用,及其对父母识别儿童面部五种基本情绪(快乐、愤怒、悲伤、恐惧和厌恶)能力的影响。抑郁症状由《简明症状量表-18》(BSI-18)的抑郁分量表测量,虐待史由《儿童创伤问卷》(CTQ)评估。我们的研究结果表明,抑郁症状会缓和父母的童年虐待史与情绪识别能力之间的关系。我们的研究结果表明,抑郁症状缓和了父母的童年虐待史与情绪识别能力之间的关系。抑郁症状较重的父母在未经历虐待时的情绪识别准确率较低。当童年虐待严重时,所有抑郁程度的父母的情绪识别能力都比较一致。这些研究结果突显了不同的经历会如何影响父母的情绪识别能力,并强调了针对个人情况进行干预以提高其有效性的必要性。
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引用次数: 0
Investigating the association between discrimination, internalizing symptoms, and alcohol use among Latino/a immigrant in the United States 调查美国拉美裔移民中歧视、内化症状和酗酒之间的关联
Pub Date : 2024-06-05 DOI: 10.3389/fpsyt.2024.1358648
Miracle A. Macias Burgos, Tara Bautista, Yesenia Cruz-Carrillo, Mia Cisco, Sumeyra Sahbaz, Lea Nehme, Duyen Vo, Maria Duque, Seth J. Schwartz, P. Montero-Zamora
Internalizing symptoms associated with anxiety and depression have been correlated with harmful alcohol use among Latino/as, but little attention has been paid to assessing the association between perceived discrimination and harmful alcohol use. The present study was designed to investigate the association between perceived discrimination, internalizing symptoms associated with anxiety and depression, and harmful alcohol use among Latino/a immigrants living in the United States (US). Our sample included 426 Latino/a immigrants. Their mean age was 40.05 years (SD = 6.50), 65.50% were women, 80.00% had a partner, 54.20% lived on less than $2,000 a month, and 41.50% reported having attained a college degree. Perceived discrimination was assessed using the Perceived Discrimination Scale, anxious symptoms were assessed using the GAD-7, depressive symptoms were assessed using the CES-D short form, and harmful alcohol use was assessed using AUDIT. We estimated a linear regression model using cross-sectional, self-reported data. The model was statistically significant, R2 = 0.38, F (8, 425) = 32.09, p < 0.01. Discrimination was significantly associated with AUDIT scores, (β = 0.21, p < 0.01) after accounting for covariates and for symptoms of anxiety and depression. Our results indicate that experiences of discrimination in the US are associated with increased harmful alcohol use even after controlling for other variables. These findings may be useful in designing coping interventions specifically for Latino/a immigrants to reduce the risk of alcohol use disorder. This study also has political and public health implications for acknowledging the detrimental health consequences of experiencing discrimination, providing support to the position that reducing racism and discrimination represent important public health priorities.
在拉丁裔美国人中,与焦虑和抑郁相关的内化症状与有害饮酒有关联,但很少有人关注评估感知到的歧视与有害饮酒之间的关联。本研究旨在调查居住在美国的拉美裔移民中感知到的歧视、与焦虑和抑郁相关的内化症状与有害饮酒之间的关联。我们的样本包括 426 名拉丁裔移民。他们的平均年龄为 40.05 岁(SD = 6.50),65.50% 为女性,80.00% 有伴侣,54.20% 每月生活费不足 2,000 美元,41.50% 表示已获得大学学位。我们使用感知歧视量表(Perceived Discrimination Scale)评估感知歧视情况,使用 GAD-7 评估焦虑症状,使用 CES-D 短表评估抑郁症状,使用 AUDIT 评估有害饮酒情况。我们使用自我报告的横截面数据估算了一个线性回归模型。该模型具有统计学意义,R2 = 0.38,F (8, 425) = 32.09,P < 0.01。在考虑了协变量以及焦虑和抑郁症状之后,歧视与 AUDIT 分数有明显相关性(β = 0.21,p < 0.01)。我们的研究结果表明,即使在控制了其他变量之后,在美国遭受歧视的经历仍与有害酒精使用的增加有关。这些发现可能有助于设计专门针对拉丁裔移民的应对干预措施,以降低酒精使用障碍的风险。这项研究还具有政治和公共卫生方面的意义,即承认遭受歧视对健康的有害影响,支持减少种族主义和歧视是重要的公共卫生优先事项这一立场。
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引用次数: 0
Everyday life for patients with schizophrenia and severely impaired social functioning 精神分裂症和社会功能严重受损患者的日常生活
Pub Date : 2024-06-05 DOI: 10.3389/fpsyt.2024.1399935
Nanna Yosser Ben Høier, Ida-Marie Molstrom, A. Urfer-Parnas, M. G. Henriksen, J. Nordgaard
A structure of everyday life creates routines and a sense of familiarity, which provides a recognizable basis for being and acting in the world. A structure of everyday life reduces stress, and daily stress has consistently been associated with higher levels of psychiatric symptoms. Little is known about how patients with schizophrenia and severe social impairment structure their lives. Thus, we aimed to explore the everyday lives of this group of patients, looking for structuring elements.In this qualitative study, we included patients diagnosed with schizophrenia who were either homeless or had difficulties reporting for treatment and, thus, needed treatment from an outreach team.17 participants were included in the study. We found only few structuring elements across all participants in the qualitative analyses. We identified five themes in our sample that serve as structuring elements in the everyday life: social interactions, volunteering to assist with basic tasks, self-initiated routines such as going for a walk daily, exoskeleton (structure provided by others), and having pets. None of the participants reported much activity during the day, and for most of them, social interactions were minimal.All the participants had very little structure and routines in their everyday life. The shelters provided the homeless participants with some structuring elements, whereas the domiciled participants had no external structuring elements. The findings have important implications for psychosocial treatment of severe social impairment in schizophrenia. The lack of structure in these patients’ everyday lives highlights the need for targeted interventions that could facilitate such structures and guide social involvement and personal recovery.
日常生活的结构创造了常规和熟悉感,为在世界上的存在和行动提供了可识别的基础。日常生活的结构可以减轻压力,而日常压力一直与较高程度的精神症状有关。人们对精神分裂症患者和严重社交障碍患者如何安排自己的生活知之甚少。在这项定性研究中,我们纳入了 17 名被诊断为精神分裂症的患者,他们要么无家可归,要么难以报到接受治疗,因此需要外展团队的治疗。在定性分析中,我们发现所有参与者的结构元素都很少。在我们的样本中,我们发现有五个主题可作为日常生活中的结构性元素:社会交往、自愿协助完成基本任务、自我发起的例行活动(如每天散步)、外骨骼(由他人提供的结构)和养宠物。所有参与者的日常生活都非常缺乏条理和常规。收容所为无家可归的参与者提供了一些结构性元素,而有家的参与者则没有任何外部结构性元素。这些发现对精神分裂症患者严重社交障碍的心理治疗具有重要意义。这些患者的日常生活缺乏结构性,这突出表明有必要采取有针对性的干预措施,以促进这种结构,并引导他们参与社会和实现个人康复。
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引用次数: 0
The relationship between self-stigma and quality of life in long-term hospitalized patients with schizophrenia: a cross-sectional study 精神分裂症长期住院患者的自我耻辱感与生活质量之间的关系:一项横断面研究
Pub Date : 2024-06-05 DOI: 10.3389/fpsyt.2024.1366030
Fuquan Liu, Hu Deng, Na Hu, Wenqian Huang, Hong Wang, Lin Liu, Jiabao Chai, Ying Li
To investigate self-stigma’s influence on schizophrenia patients’ quality of life and its mediated impact by various factors.This study adopted a cross-sectional design and randomly selected 170 hospitalized patients with schizophrenia for evaluation. The assessment tools included the Positive and Negative Syndrome Scale (PANSS), Internalized Stigma of Mental Illness Scale (ISMI), Schizophrenia Quality of Life Scale (SQLS), and Coping Questionnaire for Schizophrenia Patients (CQSP), among others. Correlation analysis, regression analysis, and mediation analysis were used to test the correlation and mediation effects.Self-stigma had a significant impact on quality of life (T = 8.13, p = 0.00). When self-stigma is used as a mediator, the problem-solving factor in coping strategies has an indirect effect on quality of life, which is significant (AB = -0.16, P = 0.02), while the avoidance factor in coping strategies has a direct effect on quality of life, which is significant (C’ = 0.54, p < 0.001), and an indirect effect, which is also significant (AB = 0.25, p < 0.001).The study highlights the significant impact of self-stigma on the quality of life of schizophrenia patients, emphasizing the crucial roles of self-esteem and coping strategies. These findings suggest clinical interventions to improve quality of life should focus on reducing self-stigma, especially enhancing self-esteem and promoting adaptive coping strategies. By addressing these factors, we can better support the mental health and well-being of those with schizophrenia, offering an effective approach to rehabilitation.
本研究采用横断面设计,随机抽取 170 名住院精神分裂症患者进行评估。评估工具包括阳性和阴性综合征量表(PANSS)、精神疾病内部化羞辱量表(ISMI)、精神分裂症生活质量量表(SQLS)和精神分裂症患者应对问卷(CQSP)等。采用相关分析、回归分析和中介分析来检验相关性和中介效应。当以自我污名作为中介时,应对策略中的问题解决因子对生活质量有间接影响,影响显著(AB = -0.16,P = 0.02),而应对策略中的回避因子对生活质量有直接影响,影响显著(C' = 0.该研究强调了自我污名对精神分裂症患者生活质量的重要影响,强调了自尊和应对策略的关键作用。这些研究结果表明,改善生活质量的临床干预措施应侧重于减少自我污名,尤其是增强自尊和促进适应性应对策略。通过解决这些因素,我们可以更好地支持精神分裂症患者的心理健康和福祉,为他们提供有效的康复方法。
{"title":"The relationship between self-stigma and quality of life in long-term hospitalized patients with schizophrenia: a cross-sectional study","authors":"Fuquan Liu, Hu Deng, Na Hu, Wenqian Huang, Hong Wang, Lin Liu, Jiabao Chai, Ying Li","doi":"10.3389/fpsyt.2024.1366030","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1366030","url":null,"abstract":"To investigate self-stigma’s influence on schizophrenia patients’ quality of life and its mediated impact by various factors.This study adopted a cross-sectional design and randomly selected 170 hospitalized patients with schizophrenia for evaluation. The assessment tools included the Positive and Negative Syndrome Scale (PANSS), Internalized Stigma of Mental Illness Scale (ISMI), Schizophrenia Quality of Life Scale (SQLS), and Coping Questionnaire for Schizophrenia Patients (CQSP), among others. Correlation analysis, regression analysis, and mediation analysis were used to test the correlation and mediation effects.Self-stigma had a significant impact on quality of life (T = 8.13, p = 0.00). When self-stigma is used as a mediator, the problem-solving factor in coping strategies has an indirect effect on quality of life, which is significant (AB = -0.16, P = 0.02), while the avoidance factor in coping strategies has a direct effect on quality of life, which is significant (C’ = 0.54, p < 0.001), and an indirect effect, which is also significant (AB = 0.25, p < 0.001).The study highlights the significant impact of self-stigma on the quality of life of schizophrenia patients, emphasizing the crucial roles of self-esteem and coping strategies. These findings suggest clinical interventions to improve quality of life should focus on reducing self-stigma, especially enhancing self-esteem and promoting adaptive coping strategies. By addressing these factors, we can better support the mental health and well-being of those with schizophrenia, offering an effective approach to rehabilitation.","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141383765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Psychometrics in Psychiatry 2022: Autism 社论:精神病学中的心理测量学 2022:自闭症
Pub Date : 2024-06-05 DOI: 10.3389/fpsyt.2024.1416556
Flavia Lecciso, Antonio Narzisi
{"title":"Editorial: Psychometrics in Psychiatry 2022: Autism","authors":"Flavia Lecciso, Antonio Narzisi","doi":"10.3389/fpsyt.2024.1416556","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1416556","url":null,"abstract":"","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141385236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of smart technology use on sleep quality in individuals with autism spectrum disorder: a mixed-methods investigation 智能技术的使用对自闭症谱系障碍患者睡眠质量的影响:一项混合方法调查
Pub Date : 2024-05-24 DOI: 10.3389/fpsyt.2024.1411993
Mohamed Abouzed, Basem Salama, Amgad Gabr, Khaled A. Elag, Mahmoud Soliman, Nisrin Elsaadouni, N. Elzahab
Sleep disturbances are common among individuals with autism spectrum disorder (ASD) and can have a negative impact on their daily functioning and core symptoms. As the use of smart technologies continues to rise, it is crucial to understand how these devices affect the sleep quality of individuals with ASD.The objective of this study was to examine the relationship between the use of smart technology and sleep quality in individuals with ASD.A mixed-methods approach was employed, combining both quantitative and qualitative data collection techniques. A sample of 83 individuals with ASD, aged between 8 and 25 years, assessed their sleep quality using the Pittsburgh Sleep Quality Index. Additionally, information regarding patterns of smart technology use and relevant covariates was collected. Correlation and regression analyses were conducted to analyze the data. Furthermore, semi-structured interviews were conducted with a subset of participants and their caregivers.Significant positive correlations were found between poorer sleep quality scores and total screen time (r = 0.42, p < 0.001), pre-bedtime technology use (r = 0.51, p < 0.001), gaming (r = 0.32, p = 0.003), and social media use (r = 0.29, p = 0.008). Pre-bedtime technology use was a significant predictor of poorer sleep quality (β = 0.32, p = 0.006), even after controlling for age, gender, and ASD severity.The findings of this study emphasize the significant associations between the use of smart technology, particularly before bedtime, and poorer sleep quality in individuals with ASD. These results underscore the importance of developing evidence-based interventions and guidelines to promote healthy sleep habits and mitigate the negative effects of technology exposure in this population.
睡眠障碍在自闭症谱系障碍(ASD)患者中很常见,会对他们的日常功能和核心症状产生负面影响。随着智能技术的使用不断增加,了解这些设备如何影响自闭症谱系障碍患者的睡眠质量至关重要。本研究的目的是探讨智能技术的使用与自闭症谱系障碍患者睡眠质量之间的关系。83 名年龄在 8 岁至 25 岁之间的 ASD 患者使用匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index)对其睡眠质量进行了评估。此外,还收集了有关智能技术使用模式和相关协变量的信息。对数据进行了相关分析和回归分析。结果发现,较差的睡眠质量得分与总屏幕时间(r = 0.42,p < 0.001)、睡前技术使用(r = 0.51,p < 0.001)、游戏(r = 0.32,p = 0.003)和社交媒体使用(r = 0.29,p = 0.008)之间存在显著的正相关。即使在控制了年龄、性别和自闭症严重程度之后,睡前使用科技仍可显著预测较差的睡眠质量(β = 0.32,p = 0.006)。本研究结果强调了智能科技的使用(尤其是睡前使用)与自闭症患者较差的睡眠质量之间的显著关联。这些结果强调了制定循证干预措施和指南的重要性,以促进该人群养成健康的睡眠习惯并减轻接触科技的负面影响。
{"title":"Impact of smart technology use on sleep quality in individuals with autism spectrum disorder: a mixed-methods investigation","authors":"Mohamed Abouzed, Basem Salama, Amgad Gabr, Khaled A. Elag, Mahmoud Soliman, Nisrin Elsaadouni, N. Elzahab","doi":"10.3389/fpsyt.2024.1411993","DOIUrl":"https://doi.org/10.3389/fpsyt.2024.1411993","url":null,"abstract":"Sleep disturbances are common among individuals with autism spectrum disorder (ASD) and can have a negative impact on their daily functioning and core symptoms. As the use of smart technologies continues to rise, it is crucial to understand how these devices affect the sleep quality of individuals with ASD.The objective of this study was to examine the relationship between the use of smart technology and sleep quality in individuals with ASD.A mixed-methods approach was employed, combining both quantitative and qualitative data collection techniques. A sample of 83 individuals with ASD, aged between 8 and 25 years, assessed their sleep quality using the Pittsburgh Sleep Quality Index. Additionally, information regarding patterns of smart technology use and relevant covariates was collected. Correlation and regression analyses were conducted to analyze the data. Furthermore, semi-structured interviews were conducted with a subset of participants and their caregivers.Significant positive correlations were found between poorer sleep quality scores and total screen time (r = 0.42, p < 0.001), pre-bedtime technology use (r = 0.51, p < 0.001), gaming (r = 0.32, p = 0.003), and social media use (r = 0.29, p = 0.008). Pre-bedtime technology use was a significant predictor of poorer sleep quality (β = 0.32, p = 0.006), even after controlling for age, gender, and ASD severity.The findings of this study emphasize the significant associations between the use of smart technology, particularly before bedtime, and poorer sleep quality in individuals with ASD. These results underscore the importance of developing evidence-based interventions and guidelines to promote healthy sleep habits and mitigate the negative effects of technology exposure in this population.","PeriodicalId":506619,"journal":{"name":"Frontiers in Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141101709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Frontiers in Psychiatry
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