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S3-Leitlinie „Adulte Weichgewebesarkome“ S3成人软组织肉瘤指南
4区 医学 Q3 Medicine Pub Date : 2022-04-26 DOI: 10.1007/s00104-022-01632-9
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引用次数: 5
[Laparoscopic sentinel node navigation surgery in gastric cancer to reduce surgical radicality]. 腹腔镜胃癌前哨淋巴结导航手术减少手术根治性。
4区 医学 Q3 Medicine Pub Date : 2022-04-12 DOI: 10.1007/s00104-022-01642-7
S. Axt, M. Anthuber
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引用次数: 0
Patientenorientierung 患者方向
4区 医学 Q3 Medicine Pub Date : 2022-04-07 DOI: 10.1007/s00104-022-01629-4
André L. Mihaljevic, C. Michalski, U. Kaisers, Guido Strunk
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引用次数: 1
[Management of lateral abdominal wall hernias]. [腹侧壁疝气的处理]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-11-23 DOI: 10.1007/s00104-021-01537-z
Gernot Köhler, Richard Kaltenböck, Hans-Jörg Fehrer, Reinhold Függer, Odo Gangl

Lateral abdominal wall hernias are rare and inconsistently defined, which is why the use of the European Hernia Society classification makes sense, not least for the purpose of comparing the quality of surgical results. A distinction must be made between true fascial defects and denervation atrophy. Based on the available literature, there is generally a low level of evidence with no consensus on the best operative strategy. The proximity to bony structures and the complex anatomy of the three-layer abdominal wall make the technical treatment of lateral hernias difficult. The surgical variations include laparoendoscopic, robotic, minimally invasive, open or hybrid approaches with different mesh positions in relation to the layers of the abdominal wall. The extensive preperitoneal mesh reinforcement open, transabdominal peritoneal (TAPP) laparoscopic repair or total extraperitoneal (TEP) endoscopic repair has met with the greatest approval. The extent of the required medial mesh overlap is determined by the distance between the medial defect boundary and the lateral edge of the straight rectus abdominus muscles. The medially directed preperitoneal and retroperitoneal dissection can be extended into the homolateral retrorectus compartment by laterally incising the posterior rectus sheath or by crossing the midline behind the intact linea alba into the contralateral retrorectus compartment. The intraperitoneal onlay mesh (IPOM) technique is a suitable procedure only for smaller defects with possible defect closure but it is also important as an exit strategy in the case of a defective peritoneum. Individualized prehabilitative and preconditioning measures are just as important as the assessment of preoperative anamnestic and clinical findings and risks with radiographic cross-sectional imaging diagnostics.

腹壁外侧疝非常罕见,定义也不一致,因此使用欧洲疝气协会的分类方法是有意义的,尤其是为了比较手术结果的质量。必须区分真正的筋膜缺损和神经支配萎缩。从现有文献来看,证据水平普遍较低,最佳手术策略尚未达成共识。外侧疝邻近骨性结构,且腹壁三层解剖结构复杂,这给外侧疝的技术治疗带来了困难。手术方法多种多样,包括腹腔镜、机器人、微创、开腹或混合手术,网片与腹壁各层的位置也各不相同。腹膜前广泛网片加固开放式、经腹腹膜(TAPP)腹腔镜修复术或全腹膜外(TEP)内窥镜修复术最受欢迎。所需的内侧网片重叠范围取决于内侧缺损边界与腹直肌外侧边缘之间的距离。内侧定向的腹膜前和腹膜后剥离可通过横向切开直肌后鞘或在完整白线后方穿过中线进入对侧直肌后间隙而扩展到同侧直肌后间隙。腹膜内嵌网(IPOM)技术仅适用于较小的腹膜缺损,并有可能进行缺损闭合,但作为腹膜缺损情况下的一种退出策略也很重要。个性化的术前康复和预处理措施与术前肛门和临床检查结果评估以及放射横断面成像诊断风险同样重要。
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引用次数: 0
[Minimum volume requirements-perspective of a tertiary care hospital]. [最低容量需求——三级护理医院的视角]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2022-01-05 DOI: 10.1007/s00104-021-01557-9
Natascha C Nüssler, Thomas Klier, Reinhard Ruppert

Background: The increase of minimum volumes for complex esophageal resections decided by the Federal Joint Committee (GBA) in Germany is currently the subject of intensive discussions.

Objective: To shed light on the effects of minimum volume requirements from the perspective of a tertiary care hospital.

Results: Strict adherence to the valid minimum volume requirements for esophageal surgery would significantly reduce the number of hospitals offering these procedures in Germany. The associated loss of revenue should not have any relevant negative economic consequences for most hospitals; however, the loss of complex esophageal surgery may result in a competitive disadvantage for these hospitals in times of shortage of qualified medical personnel. Another point of criticism is the assumption that the treatment quality can be recognized based solely on the numbers of patients.

Conclusion: Despite the well-known volume-outcome relationship, minimum volume requirements do not define the lower limit of quality of surgical treatment. Therefore, additional evidence of treatment quality, such as structural or process quality as well as outcome parameters should be required, e.g. through certification. An obligatory synchronous certification could contribute to increasing the acceptance of minimum volume requirements in Germany.

背景:德国联邦联合委员会(GBA)决定增加复杂食管切除术的最小体积,这是目前激烈讨论的主题。目的:从三级医院的角度阐明最小容量要求的影响。结果:严格遵守食道手术的有效最小容量要求将大大减少德国提供这些手术的医院数量。相关的收入损失不应对大多数医院造成任何相关的负面经济后果;然而,在缺乏合格医务人员的情况下,失去复杂的食管手术可能会导致这些医院在竞争中处于劣势。另一个批评的观点是,假设治疗质量可以仅仅根据患者的数量来判断。结论:尽管众所周知体积与预后的关系,但最小体积要求并不能定义手术治疗质量的下限。因此,治疗质量的额外证据,如结构或工艺质量以及结果参数,应要求,例如通过认证。强制性的同步认证有助于提高德国对最低产量要求的接受程度。
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引用次数: 1
[ASCO guideline for the management of stage III NSCLC part 3: indications for neoadjuvant therapy]. [ASCO III期NSCLC治疗指南第3部分:新辅助治疗的适应症]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2022-02-18 DOI: 10.1007/s00104-022-01602-1
Khosro Hekmat, Christiane J Bruns
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引用次数: 0
[Stoma-associated complications-Prevention strategy and treatment concepts]. 【吻合口相关并发症的预防策略及治疗理念】。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-06-17 DOI: 10.1007/s00104-021-01438-1
Georgi Kalev, Christoph Marquardt, Thomas Schiedeck

Postoperative complications after the creation of an intestinal stoma have a considerable impact on the patient's quality of life. The accurate surgical technique is very important for their prevention and requires profound surgical knowledge as well as sufficient experience. The importance of the preoperative consultation as well as the postoperative care by stoma therapists is clearly proven. Depending on the severity of the complication, outpatient conservative treatment is initially indicated. A surgical local revision or laparotomy should only be considered if conservative treatment is no longer sufficient, whereby the indications for surgery should be set very cautiously. This article provides an overview of the current evidence regarding the prevention and treatment of postoperative stoma complications.

肠造口术后并发症对患者的生活质量有相当大的影响。准确的手术技术对预防这些疾病非常重要,需要深厚的外科知识和足够的经验。术前咨询的重要性以及术后护理的造口治疗师是明确证明。根据并发症的严重程度,最初需要进行门诊保守治疗。只有当保守治疗不再足够时,才应考虑手术局部翻修或剖腹手术,因此手术指征应非常谨慎地确定。本文概述了目前关于预防和治疗术后造口并发症的证据。
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引用次数: 1
[Epigastric pain in "gastric tumors" : The hummingbird among the differential diagnoses]. 【“胃肿瘤”的胃脘痛:蜂鸟在鉴别诊断中的应用】。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-10-19 DOI: 10.1007/s00104-021-01522-6
Ines Gockel, Wolfgang Hartmann, Hannes Köhler, Jakob Leonhardi, Simone Heyn, René Thieme
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引用次数: 0
[The proximally pedicled anterolateral thigh flap for reconstruction of complex soft tissue wounds of the hip and caudal trunk region]. [近端带蒂股前外侧皮瓣重建髋关节及尾干区复杂软组织创伤]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-08-25 DOI: 10.1007/s00104-021-01483-w
H Lauer, O Goertz, K Landscheidt, J F Hernekamp

Introduction: Groin and lower trunk defects are common problems, especially for elderly patients. While groin defects are often due to prior vascular interventions, trochanteric defects are mainly caused by pressure sores. Plastic reconstructive methods are manifold; however, the pedicled anterolateral thigh (ALT) flap is supposed to be reliable with sustainable results.

Objective: We present our experiences using the pedicled ALT flap for soft tissue reconstruction in patients with large wounds of the medial and lateral proximal thigh.

Materials and methods: A total of 16 patients with groin and lower trunk defects due to prior vascular surgery or pressure sores received locoregional soft tissue reconstruction using a proximal pedicled ALT flap. Patient characteristics, defect size, surgery time, clinical outcome and complication rate were assessed.

Results: With the exception of two cases, sufficient soft tissue reconstruction was achieved. In all, 81,3% of patients were categorized as ASA (American Society of Anesthesiologists) 3. The average duration of surgery was 149 min. Length of stay was 18,3 days. A total of 31% needed revision surgery due to limited wound healing problems. Two patients died. All patients showed healed wound conditions when they were discharged.

Conclusion: The proximal pedicled ALT-flap is a reliable method for soft tissue reconstruction in groin and lower trunk defects. This reconstructive procedure enables reliable wound closure, especially in elderly patients with substantially reduced general health condition.

腹股沟和下躯干缺损是常见的问题,尤其是老年患者。虽然腹股沟缺陷通常是由于先前的血管干预,转子缺陷主要是由压疮引起的。塑性重建方法是多种多样的;然而,带蒂大腿前外侧皮瓣(ALT)被认为是可靠的和可持续的结果。目的:介绍带蒂ALT皮瓣在股骨近端大块创面重建中的应用经验。材料与方法:采用近端带蒂ALT皮瓣对16例既往血管手术或压疮所致腹股沟及下干缺损患者进行局部软组织重建。评估患者特征、缺损大小、手术时间、临床结果及并发症发生率。结果:除2例外,均获得充分的软组织重建。总的来说,81.3%的患者被归类为ASA(美国麻醉医师协会)3。手术时间平均为149 min。住院时间为18.3天。由于伤口愈合问题有限,总共有31%的患者需要翻修手术。两名患者死亡。所有患者出院时伤口均愈合。结论:近端带蒂alt皮瓣是修复腹股沟及下干软组织缺损的可靠方法。这种重建程序能够可靠地关闭伤口,特别是对于一般健康状况明显下降的老年患者。
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引用次数: 1
The Glycocalyx Shedding Influences Hemodynamic and Metabolic Response to Fluid Load in Septic Shock. 糖萼脱落影响脓毒性休克患者对液体负荷的血流动力学和代谢反应
IF 0.6 4区 医学 Q3 Medicine Pub Date : 2022-04-01 DOI: 10.5152/TJAR.2021.21224
Yana Ilyina, Eugenia Fot, Vsevolod Kuzkov, Mikhail Kirov

Objective: Sepsis-associated endothelial dysfunction and degradation result in release of inflammatory mediators, compromise endothelial permeability, and impair alveolar fluid clearance leading to pulmonary edema. Excessive fluid therapy in septic shock damage the endothelial glycocalyx which will increase capillary leakage. The aim of our study was to assess the relationship of endothelial glycocalyx shedding with hemodynamic and metabolic response to fluid load in patients with septic shock.

Methods: Eighteen adult patients were included in prospective observational study. To predict the response to infusion, we performed fluid load test by using crystalloids 7 mL kg-1 for 10 minutes. The plasma concentrations of endothelial glycocalyx components including heparan sulfate proteoglycan and syndecan 1 were measured at baseline, 2, 24 hours after fluid load test.

Results: We observed associations of syndecan 1 with extravascular lung water index (rho = 0.48, P =.04) at baseline and of heparan sulfate proteoglycan with extravascular lung water index (rho= -0.56, P = .03) and pulse pressure variation (rho = 0.53, P = .04) at 24 hours after fluid load test. The plasma concentration of syndecan 1 correlated with lactate at baseline (rho = 0.51, P = .02) and at 24 hours after fluid load test (rho = 0.76, P = .009). At 2 hours after fluid load test, the concentration of syndecan 1 correlated with global end-diastolic volume index (rho= 0.93, P = .001) in normovolemic patients.

Conclusions: The shedding of endothelial glycocalyx after fluid load test in septic shock is associated with hemodynamic and metabolic responses and related with the severity of pulmonary edema.

目的:脓毒症相关的内皮功能障碍和退化会导致炎症介质的释放、内皮通透性受损以及肺泡液体清除障碍,从而导致肺水肿。脓毒性休克时过度的液体治疗会损伤内皮糖萼,从而增加毛细血管渗漏。我们的研究旨在评估脓毒性休克患者内皮糖萼脱落与血液动力学和代谢对液体负荷反应的关系:方法:18 名成年患者被纳入前瞻性观察研究。为了预测输液反应,我们使用晶体液 7 mL kg-1 进行了 10 分钟的液体负荷试验。在基线、液体负荷试验后 2 小时和 24 小时测量血浆中内皮糖萼成分(包括硫酸肝素蛋白多糖和辛迪加 1)的浓度:我们观察到,在基线时,辛迪加 1 与血管外肺水指数相关(rho = 0.48,P =.04);在液体负荷试验后 24 小时,硫酸肝素蛋白多糖与血管外肺水指数(rho = -0.56,P = .03)和脉压变化(rho = 0.53,P = .04)相关。在基线(rho = 0.51,P = .02)和液体负荷试验后 24 小时(rho = 0.76,P = .009),血浆中辛迪加 1 的浓度与乳酸相关。在液体负荷试验后 2 小时,正常血容量患者的辛迪加 1 浓度与整体舒张末期容积指数相关(rho = 0.93,P = .001):结论:脓毒性休克患者在液体负荷试验后内皮糖萼脱落与血流动力学和代谢反应有关,并与肺水肿的严重程度相关。
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Chirurg
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