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Predicting circRNA-Disease Associations by Using Multi-Biomolecular Networks Based on Variational Graph Auto-Encoder with Attention Mechanism 利用基于带有注意机制的变异图自动编码器的多生物分子网络预测 circRNA 与疾病的关联性
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-11-11 DOI: 10.23919/cje.2023.00.344
Jing Yang;Xiujuan Lei;Yi Pan
CircRNA-disease association (CDA) can provide a new direction for the treatment of diseases. However, traditional biological experiment is time-consuming and expensive, this urges us to propose the reliable computational model to predict the associations between circRNAs and diseases. And there is existing more and more evidence indicates that the combination of multi-biomolecular information can improve the prediction accuracy. We propose a novel computational model for CDA prediction named MBCDA, we collect the multi-biomolecular information including circRNA, disease, miRNA and lncRNA based on 6 databases, and construct three heterogeneous network among them, then the multi-heads graph attention networks are applied to these three networks to extract the features of circRNAs and diseases from different views, the obtained features are put into variational graph auto-encoder (VGAE) network to learn the latent distributions of the nodes, a fully connected neural network is adopted to further process the output of VGAE and uses sigmoid function to obtain the predicted probabilities of circRNA-disease pairs. As a result, MBCDA achieved the values of AUC and AUPR under 5-fold cross-validation of 0.893 and 0.887. MBCDA was applied to the analysis of the top-25 predicted associations between circRNAs and diseases, these experimental results show that our proposed MBCDA is a powerful computational model for CDA prediction.
循环RNA与疾病的关联(CDA)可以为疾病治疗提供新的方向。然而,传统的生物学实验耗时长、成本高,这就促使我们提出可靠的计算模型来预测 circRNA 与疾病之间的关联。越来越多的证据表明,结合多种生物分子信息可以提高预测的准确性。我们基于6个数据库收集了包括circRNA、疾病、miRNA和lncRNA在内的多生物分子信息,并在它们之间构建了三个异构网络,然后对这三个网络应用多头图注意网络,从不同视图中提取circRNA和疾病的特征、将获得的特征放入变异图自动编码器(VGAE)网络中学习节点的潜在分布,然后采用全连接神经网络进一步处理 VGAE 的输出,并使用 sigmoid 函数获得 circRNA-疾病配对的预测概率。结果,MBCDA在5倍交叉验证下的AUC值和AUPR值分别达到了0.893和0.887。这些实验结果表明,我们提出的MBCDA是一种强大的CDA预测计算模型。
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引用次数: 0
Sharper Hardy Uncertainty Relations on Signal Concentration in Terms of Linear Canonical Transform 用线性典型变换表示信号浓度的更清晰哈代不确定性关系
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2023.00.096
Xiaogang Xu;Guanlei Xu;Xiaotong Wang
Linear canonical transform is of much significance to optics and information science. Hardy uncertainty principle, like Heisenberg uncertainty principle, plays an important role in various fields. In this paper, four new sharper Hardy uncertainty relations on linear canonical transform are derived. These new derived uncertainty relations are connected with the linear canonical transform parameters and indicate new insights for signal energy concentration. Especially, for certain transform parameters, e.g. $b=0$, these new proposed uncertainty relations break the traditional counterparts in signal energy concentration, as will result in new physical interpretation in terms of uncertainty principle. Theoretical analysis and numerical examples are given to show the efficiency of these new relations.
线性典型变换对光学和信息科学具有重要意义。哈代不确定性原理与海森堡不确定性原理一样,在各个领域发挥着重要作用。本文推导了线性典型变换的四个新的更尖锐的哈代不确定关系。这些新推导出的不确定性关系与线性规范变换参数相关联,为信号能量集中提供了新的启示。特别是对于某些变换参数,如 $b=0$,这些新提出的不确定性关系打破了信号能量集中的传统对应关系,并将从不确定性原理的角度产生新的物理解释。理论分析和数值示例展示了这些新关系的效率。
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引用次数: 0
Distributed Cell-Free Massive MIMO Versus Cellular Massive MIMO Under UE Hardware Impairments UE 硬件损伤下的分布式无蜂窝大规模多输入多输出(MIMO)与蜂窝大规模多输入多输出(MIMO
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2023.00.045
Ning Li;Pingzhi Fan
This paper first investigates and compares the uplink spectral efficiency (SE) of distributed cell-free massive multiple-input multiple-output (mMIMO) and cellular mMIMO networks, both with user equipment (UE) hardware impairments. We derive a lower bound on the uplink ergodic channel capacity of the cellular mMIMO with UE hardware impairments, based on which we determine the optimal receive combining that maximizes the instantaneous effective signal-to-interference-and-noise ratio. Then, a lower bound on the uplink capacity of a distributed cell-free mMIMO with UE hardware impairments is derived using the use-and-then-forget technique. On this basis, the optimum large-scale fading decoding vector is found using generalized Rayleigh entropy. By using three combining schemes of minimum mean-square error (MMSE), regularized zero-forcing (RZF), and maximum ratio, the uplink SEs of distributed cell-free mMIMO and cellular mMIMO networks are analyzed and compared. The results show that the two-layer decoding distributed cell-free mMIMO network with MMSE combining outperforms the cellular mMIMO network, and the advantage is more evident as the hardware impairment factor increases. Finally, the uplink energy efficiency (EE) of the distributed cell-free mMIMO networks is analyzed and evaluated through the established realistic power consumption model with hardware impairments. Simulation results show that two-layer decoding provides higher SE and EE than single-layer decoding. In addition, RZF achieves almost the same SE and EE as MMSE in a two-layer decoding architecture.
本文首先研究并比较了分布式无小区大规模多输入多输出(mMIMO)网络和蜂窝 mMIMO 网络的上行链路频谱效率(SE),这两种网络都存在用户设备(UE)硬件损伤。我们推导出了具有 UE 硬件损伤的蜂窝 mMIMO 的上行链路遍历信道容量下限,并在此基础上确定了使瞬时有效信噪比最大化的最佳接收组合。然后,利用 "先使用后遗忘 "技术推导出具有 UE 硬件损伤的分布式无小区 mMIMO 的上行链路容量下限。在此基础上,利用广义瑞利熵找到了最佳大规模衰落解码向量。通过使用最小均方误差(MMSE)、正则化零强迫(RZF)和最大比率三种组合方案,分析并比较了分布式无蜂窝 mMIMO 网络和蜂窝 mMIMO 网络的上行链路 SE。结果表明,采用 MMSE 组合的双层解码分布式无蜂窝 mMIMO 网络优于蜂窝 mMIMO 网络,而且随着硬件损伤因子的增加,其优势更加明显。最后,通过已建立的具有硬件损伤的现实功耗模型,分析和评估了分布式无蜂窝 mMIMO 网络的上行链路能效(EE)。仿真结果表明,与单层解码相比,双层解码能提供更高的 SE 和 EE。此外,在双层解码架构中,RZF 实现了与 MMSE 几乎相同的 SE 和 EE。
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引用次数: 0
Design of Differential Multi-Point Feeding Dual-Polarized SISL Antenna Based on CM Analysis 基于 CM 分析的差分多点馈电双极化 SISL 天线设计
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2022.00.251
Bin Tang;Kaixue Ma;Eric Newton Moro;Yu Luo
Dual-polarized antennas are required in the current mobile communication to increase the channel capacity and reducing multi-path effects. Utilizing characteristic mode (CM) analysis, this paper presents a five-patch substrate integrated suspended line (SISL) antenna with suppressed unwanted higher-order modes, and achieves an enhanced bandwidth by using differential multi-point feeding (MPF) systems. Compared to single-point feeding systems, the proposed dual-polarized SISL antenna with the MPF system demonstrates a bandwidth 1.87 times wider. The novel SISL feeding system incorporates two pairs of differentially-fed branch line feed structures. A prototype of the proposed differential-fed antenna is fabricated and measured, showing good agreement between simulated and measured results. The dual-polarization SISL antenna can achieve realized gain from 8.1 dBi to 10.8 dBi within a working frequency from 3.17 GHz to 3.61 GHz (12.98%). Moreover, utilizing low-cost substrates, the proposed SISL antenna has the potential for 5G applications.
目前的移动通信需要双极化天线来增加信道容量和减少多径效应。本文利用特征模态(CM)分析,提出了一种抑制了不需要的高阶模态的五贴片基底集成悬浮线(SISL)天线,并通过使用差分多点馈电(MPF)系统实现了带宽的增强。与单点馈电系统相比,采用 MPF 系统的双极化 SISL 天线的带宽扩大了 1.87 倍。新型 SISL 馈电系统包含两对差分馈电支线馈电结构。对所提出的差分馈电天线原型进行了制造和测量,结果显示模拟和测量结果之间具有良好的一致性。双极化 SISL 天线可在 3.17 GHz 至 3.61 GHz 的工作频率范围内实现 8.1 dBi 至 10.8 dBi 的增益(12.98%)。此外,利用低成本基板,所提出的 SISL 天线具有 5G 应用的潜力。
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引用次数: 0
Efficient Nonnegative Tensor Decomposition Using Alternating Direction Proximal Method of Multipliers 使用交替方向近端乘法进行高效非负张量分解
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2023.00.035
Deqing Wang;Guoqiang Hu
Nonnegative CANDECOMP/PARAFAC (NCP) tensor decomposition is a powerful tool for multiway signal processing. The alternating direction method of multipliers (ADMM) optimization algorithm has become increasingly popular for solving tensor decomposition problems in the block coordinate descent framework. However, the ADMM-based NCP algorithm suffers from rank deficiency and slow convergence for some large-scale and highly sparse tensor data. The proximal algorithm is preferred to enhance optimization algorithms and improve convergence properties. In this study, we propose a novel NCP algorithm using the alternating direction proximal method of multipliers (ADPMM) that consists of the proximal algorithm. The proposed NCP algorithm can guarantee convergence and overcome the rank deficiency. Moreover, we implement the proposed NCP using an inexact scheme that alternatively optimizes the subproblems. Each subproblem is optimized by a finite number of inner iterations yielding fast computation speed. Our NCP algorithm is a hybrid of alternating optimization and ADPMM and is named $mathrm{A}^{2}text{DPMM}$. The experimental results on synthetic and real-world tensors demonstrate the effectiveness and efficiency of our proposed algorithm.
非负 CANDECOMP/PARAFAC (NCP) 张量分解是多路信号处理的有力工具。交替方向乘法(ADMM)优化算法在块坐标下降框架中解决张量分解问题方面越来越受欢迎。然而,基于 ADMM 的 NCP 算法存在秩缺陷,对于一些大规模和高度稀疏的张量数据,收敛速度较慢。近似算法是增强优化算法和改善收敛特性的首选。在本研究中,我们提出了一种使用交替方向近似乘法(ADPMM)的新型 NCP 算法,该算法由近似算法组成。所提出的 NCP 算法可以保证收敛性并克服秩缺陷。此外,我们使用一种交替优化子问题的非精确方案来实现所提出的 NCP。每个子问题都通过有限次数的内部迭代进行优化,因此计算速度很快。我们的 NCP 算法是交替优化和 ADPMM 的混合体,命名为 $mathrm{A}^{2}text{DPMM}$。在合成和真实世界张量上的实验结果证明了我们提出的算法的有效性和高效性。
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引用次数: 0
Study on Static Deflection Model of MEMS Capacitive Microwave Power Sensors 微机电系统电容式微波功率传感器静态变形模型研究
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2023.00.087
Ye Jin;Debo Wang
In this paper, a static deflection model of MEMS cantilever beam is proposed, which can better study the force deformation of micro-electro-mechanical system (MEMS) cantilever beam and the output characteristics of capacitive microwave power sensor. The deflection curve is used to describe the deformation of the cantilever beam and then the overload power and sensitivity of this power sensor are derived. It is found that the overload power decreases with the beam length, and increases with the initial height of beam. The sensitivity increases with the beam length, and has a linear growth relationship with the measuring electrode width. A MEMS dual-channel microwave power sensor is designed, fabricated and measured. At a microwave signal frequency of 10 GHz, the sensitivity of the sensor is measured to be 0.11 V/W for the thermoelectric detection channel and 65.17 fF/W for the capacitive detection channel. The sensitivity calculated by the lumped model is 92.93 fF/W, that by the pivot model is 50.88 fF/W, and that by the deflection model proposed in this work is 75.21 fF/W. Therefore, the theoretical result of the static deflection model is more consistent with the measured result and has better accuracy than the traditional lumped model and pivot model.
本文提出了微机电系统(MEMS)悬臂梁的静态变形模型,可以更好地研究微机电系统(MEMS)悬臂梁的受力变形和电容式微波功率传感器的输出特性。利用挠度曲线来描述悬臂梁的变形,然后得出该功率传感器的过载功率和灵敏度。研究发现,过载功率随悬臂梁长度的增加而减小,随悬臂梁初始高度的增加而增大。灵敏度随横梁长度的增加而增加,并与测量电极宽度呈线性增长关系。设计、制造和测量了一种 MEMS 双通道微波功率传感器。在微波信号频率为 10 GHz 时,传感器热电检测通道的灵敏度为 0.11 V/W,电容检测通道的灵敏度为 65.17 fF/W。根据块状模型计算得出的灵敏度为 92.93 fF/W,根据枢轴模型计算得出的灵敏度为 50.88 fF/W,而根据本文提出的偏转模型计算得出的灵敏度为 75.21 fF/W。因此,与传统的块状模型和枢轴模型相比,静态挠度模型的理论结果与实测结果更加一致,精度更高。
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引用次数: 0
A Microstrip Leaky-Wave Antenna with Scanning Beams Horizontal to the Antenna Plane 扫描光束水平指向天线平面的微带漏波天线
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2023.00.033
Henghui Wang;Peiyao Chen;Sheng Sun
A leaky-wave antenna with horizontal scanning beams and broadside radiation is presented on the periodically modulated microstrip. The horizontal radiation is realized by periodically etching a set of resonant open-ended slots on the ground plane. Dispersion diagrams and Bloch impedance are first analyzed to investigate the propagation and radiation characteristics of the periodic structure. Subsequently, shunt matching stubs are installed aiming to obtain seamless beam scanning property through the broadside. Finally, a prototype is implemented as verification of the presented antenna. Results of the simulations and measurements agree well with each other, indicating the elimination of the open-stop band effect and the horizontal radiation beams. The fabricated antenna exhibits a beam range from -62° to +34°, and provides a maximum measured gain about 14.6 dBi at 10 GHz.
本文介绍了一种在周期性调制微带上具有水平扫描波束和宽边辐射的漏波天线。水平辐射是通过在地平面上周期性蚀刻一组谐振开口槽来实现的。首先分析了频散图和布洛赫阻抗,以研究周期性结构的传播和辐射特性。随后,安装并联匹配存根,以获得通过宽边的无缝光束扫描特性。最后,我们制作了一个原型来验证所提出的天线。仿真和测量结果完全一致,表明消除了开阻带效应和水平辐射波束。制作的天线波束范围为 -62° 至 +34°,在 10 GHz 频率下的最大测量增益约为 14.6 dBi。
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引用次数: 0
A Polarization Control Operator for Polarized Electromagnetic Wave Designing 用于偏振电磁波设计的偏振控制算子
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2022.00.410
Shuo Cui;Yaoyao Li;Shijian Zhang;Ling Chen;Cheng Cao;Donglin Su
To describe and control the polarization state of electromagnetic waves, a polarization control operator of the complex vector form is proposed. Distinct from traditional descriptors, the proposed operator employs an angle parameter to configure the polarization state of the polarized wave. By setting the parameter in the proposed operator, the amplitude of the field components can be modified, resulting in changes in the magnitude and direction of the field vector, and thus realizing control of the polarization state of the electromagnetic wave. The physical meaning, orthogonal decomposition, and discrete property of the proposed operator are demonstrated through mathematical derivation. In the simulation examples, the polarization control operator with fixed and time-varying parameters is applied to the circularly polarized wave. The propagation waveform, the trajectory projection and the waveform cross section in different reception directions of the new electromagnetic waves are observed. The simulation results indicate that complex electromagnetic waves with more flexible polarization states can be obtained with the aid of the polarization operator.
为了描述和控制电磁波的偏振状态,我们提出了一种复矢量形式的偏振控制算子。与传统的描述符不同,所提出的算子采用角度参数来配置极化波的极化状态。通过设置拟议算子中的参数,可以改变场分量的振幅,导致场矢量的大小和方向发生变化,从而实现对电磁波极化状态的控制。通过数学推导,证明了所提算子的物理意义、正交分解和离散特性。在仿真示例中,将具有固定参数和时变参数的极化控制算子应用于圆极化波。观察了新电磁波在不同接收方向上的传播波形、轨迹投影和波形截面。仿真结果表明,借助极化算子可以获得具有更灵活极化状态的复杂电磁波。
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引用次数: 0
Realization of Complete Boolean Logic and Combinational Logic Functionalities on a Memristor-Based Universal Logic Circuit 在基于 Memristor 的通用逻辑电路上实现完整的布尔逻辑和组合逻辑功能
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2023.00.091
Xiaojuan Lian;Chuanyang Sun;Zeheng Tao;Xiang Wan;Xiaoyan Liu;Zhikuang Cai;Lei Wang
Memristors are a promising solution for building an advanced computing system due to their excellent characteristics, including small energy consumption, high integration density, fast write/read speed, great endurance and so on. In this work, we firstly design three basis logic XNOR1, XNOR2 and XOR gates by virtue of memristor ratioed logic (MRL), and further construct 1-bit numerical comparators, 2-bit numerical comparators and full adder 1 based on the above XNOR1, XNOR2 and XOR gates. Furthermore, we propose and design a universal logic circuit that can realize four different kinds of logic functions (AND, OR, XOR, XNOR) at the same time. Subsequently, a full adder 2 is built using XOR function of this universal logic circuit. Compared with the traditional CMOS circuits, the universal logic circuit designed in this work exhibits several merits such as fewer components, less power, and lower delay. This work demonstrates that memristors can be used as a potential solution for building a novel computing architecture.
忆阻器具有能耗小、集成密度高、写/读速度快、耐用性强等优良特性,是构建先进计算系统的理想解决方案。在这项工作中,我们首先利用忆阻器比值逻辑(MRL)设计了三个基础逻辑 XNOR1、XNOR2 和 XOR 门,并在上述 XNOR1、XNOR2 和 XOR 门的基础上进一步构造了 1 位数字比较器、2 位数字比较器和全加法器 1。此外,我们还提出并设计了一种通用逻辑电路,可同时实现四种不同的逻辑功能(AND、OR、XOR、XNOR)。随后,利用该通用逻辑电路的 XOR 功能构建了全加法器 2。与传统的 CMOS 电路相比,本文设计的通用逻辑电路具有元件少、功耗低、延迟小等优点。这项工作表明,忆阻器可以作为一种潜在的解决方案,用于构建新型计算架构。
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引用次数: 0
Method of Single Event Effects Radiation Hardened Design for DC-DC Converter Based Load Transient Detection 基于直流-直流转换器负载瞬态检测的单事件效应辐射加固设计方法
IF 1.6 4区 计算机科学 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2024-09-09 DOI: 10.23919/cje.2022.00.442
Zhongjie Guo;Nan Liu;Hu Lu;Mengli Li;Ziyi Qiu
Aiming at the impact of load current change on single-event transient, the essential difference between single-event transient and load transient of DC-DC converter is deeply studied. A hardened circuit based on load transient detection is proposed. The circuit detects the load transient information in time and outputs a control signal to control the single event hardened circuit, thereby realizing the improvement of the transient characteristics of the system under dynamic conditions. Based on the 180 nm bipolar-CMOS-DMOS (BCD) process, the design and physical verification of a boost converter are completed. The experimental results show that the input voltage range is 2.9-4.5 V, the output voltage range is 5.8-7.9 V, and the load current is 0–55 mA. During load transients, the load detection circuit turns off the hardened circuit in time, avoiding system oscillation and widening the dynamic range of the hardening circuit. Under the single-event transient, the output voltage fluctuation of the system does not exceed the maximum ripple voltage, and the single-event transient suppression ability reaches more than 86%, the system can work well with linear energy transfer of about $100 text{MeV}cdot text{cm}^{2}/text{mg}$.
针对负载电流变化对单事件瞬态的影响,深入研究了 DC-DC 转换器的单事件瞬态和负载瞬态之间的本质区别。提出了一种基于负载瞬态检测的加固电路。该电路能及时检测负载瞬态信息,并输出控制信号来控制单事件加固电路,从而实现动态条件下系统瞬态特性的改善。基于 180 纳米双极-CMOS-DMOS(BCD)工艺,完成了升压转换器的设计和物理验证。实验结果表明,输入电压范围为 2.9-4.5 V,输出电压范围为 5.8-7.9 V,负载电流为 0-55 mA。在负载瞬态期间,负载检测电路及时关闭加固电路,避免了系统振荡,拓宽了加固电路的动态范围。在单次瞬态下,系统的输出电压波动不超过最大纹波电压,单次瞬态抑制能力达到86%以上,系统可以很好地工作,线性能量传递约为100 text{MeV}cdot text{cm}^{2}/text{mg}$。
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引用次数: 0
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Chinese Journal of Electronics
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