Microbial metabolic engineering is a new bioengineering technology, which can improve the yield of compounds, optimize energy utilization and solve various problems faced by human beings by changing the genetic information, metabolic pathway and metabolic flux of microorganisms. Protein is the main undertaker of life activities, and its metabolic process involves complex biochemical reactions and cell regulation mechanisms. Protein metabolism plays an important role and application in microbial metabolic engineering. The purpose of this paper is to explore the metabolic effects of protein for microbial metabolic engineering, so as to deeply understand the metabolic characteristics and regulation mechanism of microorganisms. Microbial metabolic engineering has important applications in improving the yield of compounds, optimizing energy utilization, environmental treatment and medicine. The research and application of protein metabolism can provide more in-depth theoretical basis and technical support for microbial metabolism engineering, thus promoting the development and utilization of microbial resources.
{"title":"Study on Metabolic Effects of protein for Microbial Metabolic Engineering","authors":"Gan Lin","doi":"10.54097/ijbls.v3i3.12","DOIUrl":"https://doi.org/10.54097/ijbls.v3i3.12","url":null,"abstract":"Microbial metabolic engineering is a new bioengineering technology, which can improve the yield of compounds, optimize energy utilization and solve various problems faced by human beings by changing the genetic information, metabolic pathway and metabolic flux of microorganisms. Protein is the main undertaker of life activities, and its metabolic process involves complex biochemical reactions and cell regulation mechanisms. Protein metabolism plays an important role and application in microbial metabolic engineering. The purpose of this paper is to explore the metabolic effects of protein for microbial metabolic engineering, so as to deeply understand the metabolic characteristics and regulation mechanism of microorganisms. Microbial metabolic engineering has important applications in improving the yield of compounds, optimizing energy utilization, environmental treatment and medicine. The research and application of protein metabolism can provide more in-depth theoretical basis and technical support for microbial metabolism engineering, thus promoting the development and utilization of microbial resources.","PeriodicalId":507854,"journal":{"name":"International Journal of Biology and Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
At present, rural revitalization has risen to the level of national strategy, in which rural cultural revitalization is the soul of rural revitalization. As the essence of rural culture in Huizhou, the use and inheritance of Huizhou etiquette culture is particularly important. The core connotation of Huizhou etiquette culture can be summarized as "respecting etiquette, emphasizing etiquette", which has the functions of education, standardization, maintenance and regulation. Combined with the characteristics of today's society and era, the application and inheritance of Huizhou etiquette and culture should be based on the full study of the basis of adherence to some abandonment; in the inheritance of the basis of innovation; innovative use of the way to optimize the traditional way; make full use of the Internet, to open up new forms. The use and inheritance of Huizhou ritual culture is conducive to solving the "Three Rural Issues", building a beautiful countryside in Huizhou, promoting the coordinated development of the countryside, realizing the prosperity of the countryside, affluence, and achieving the goal of building a moderately prosperous society in an all-round way. At the same time, we study the production of traditional handicraft Huizhou lacquer ware and carry out regeneration design for it. On the one hand, it is of great social significance to carry forward the local culture of Huizhou, which is conducive to the improvement of the current status quo of the lack of awareness of the traditional culture of the local ethnic groups; on the other hand, it improves the state of no one to succeed the relatively lagging behind development of lacquerware craftsmanship, so that the consumers can understand and accept this traditional craftsmanship through the lacquerware cultural and creative products.
{"title":"Media Integration and Digital Inheritance: A Study of Huizhou Rituals and Lacquerware Paths under Rural Cultural Revitalization","authors":"Xue Yu, Wanqiu Lu","doi":"10.54097/ijbls.v3i3.16","DOIUrl":"https://doi.org/10.54097/ijbls.v3i3.16","url":null,"abstract":"At present, rural revitalization has risen to the level of national strategy, in which rural cultural revitalization is the soul of rural revitalization. As the essence of rural culture in Huizhou, the use and inheritance of Huizhou etiquette culture is particularly important. The core connotation of Huizhou etiquette culture can be summarized as \"respecting etiquette, emphasizing etiquette\", which has the functions of education, standardization, maintenance and regulation. Combined with the characteristics of today's society and era, the application and inheritance of Huizhou etiquette and culture should be based on the full study of the basis of adherence to some abandonment; in the inheritance of the basis of innovation; innovative use of the way to optimize the traditional way; make full use of the Internet, to open up new forms. The use and inheritance of Huizhou ritual culture is conducive to solving the \"Three Rural Issues\", building a beautiful countryside in Huizhou, promoting the coordinated development of the countryside, realizing the prosperity of the countryside, affluence, and achieving the goal of building a moderately prosperous society in an all-round way. At the same time, we study the production of traditional handicraft Huizhou lacquer ware and carry out regeneration design for it. On the one hand, it is of great social significance to carry forward the local culture of Huizhou, which is conducive to the improvement of the current status quo of the lack of awareness of the traditional culture of the local ethnic groups; on the other hand, it improves the state of no one to succeed the relatively lagging behind development of lacquerware craftsmanship, so that the consumers can understand and accept this traditional craftsmanship through the lacquerware cultural and creative products.","PeriodicalId":507854,"journal":{"name":"International Journal of Biology and Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The expansion of CAG trinucleotide repeats has been considered to be highly related to the polyglutamine disorders which effect the neuron and muscle system of organism. This study aims to investigate how knocking down HSP90 or RPL36 would affect the polyglutamine toxicity. Based on the previous experiment, the Caenorhabditis elegans that expresses polyQ proteins would show protein misfolding and aggregation. We use C. elegans as model and record the phenotype of worms, frequency of thrashing and number of aggregations under IHA microscope before and after close the target genes by RNA interference. The results of this experiment indicate that HSP90 deficiency increases polyglutamine toxicity in muscle cells, presumably by preventing polyglutamine protein aggregation. Otherwise, rpl36 knockdown suppresses polyglutamine toxicity in muscle cells, perhaps by stimulating the aggregation of polyglutamine proteins. The research work has contributed to our present understanding to polyglutamine disorder and the possible function of HSP90 and RPL36.
{"title":"Understanding Polyglutamine Diseases and Investigating the Functions of HSP90 and RPL36","authors":"Yuao Sun","doi":"10.54097/ijbls.v3i3.15","DOIUrl":"https://doi.org/10.54097/ijbls.v3i3.15","url":null,"abstract":"The expansion of CAG trinucleotide repeats has been considered to be highly related to the polyglutamine disorders which effect the neuron and muscle system of organism. This study aims to investigate how knocking down HSP90 or RPL36 would affect the polyglutamine toxicity. Based on the previous experiment, the Caenorhabditis elegans that expresses polyQ proteins would show protein misfolding and aggregation. We use C. elegans as model and record the phenotype of worms, frequency of thrashing and number of aggregations under IHA microscope before and after close the target genes by RNA interference. The results of this experiment indicate that HSP90 deficiency increases polyglutamine toxicity in muscle cells, presumably by preventing polyglutamine protein aggregation. Otherwise, rpl36 knockdown suppresses polyglutamine toxicity in muscle cells, perhaps by stimulating the aggregation of polyglutamine proteins. The research work has contributed to our present understanding to polyglutamine disorder and the possible function of HSP90 and RPL36.","PeriodicalId":507854,"journal":{"name":"International Journal of Biology and Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turner syndrome (TS), also known as congenital dysplasia of ovary syndrome, is the most common female chromosomal abnormality, and the incidence of live birth girls is 1/2 000 ~ 1/2 500. The main clinical manifestations of Turner syndrome are spinal trunk abnormality, growth retardation, sexual dysplasia and special physical characteristics, and abnormal sex hormone, abnormal growth hormone, dyslipidemia, etc. This article summarized and analyzed the clinical characteristics and test results of a child with Turner syndrome, combined with literature review, in order to improve the understanding of Turner syndrome and clinical diagnosis and treatment.
{"title":"A Case Report of Turner Syndrome and Literature Review","authors":"Pingping Chen","doi":"10.54097/ijbls.v3i3.11","DOIUrl":"https://doi.org/10.54097/ijbls.v3i3.11","url":null,"abstract":"Turner syndrome (TS), also known as congenital dysplasia of ovary syndrome, is the most common female chromosomal abnormality, and the incidence of live birth girls is 1/2 000 ~ 1/2 500. The main clinical manifestations of Turner syndrome are spinal trunk abnormality, growth retardation, sexual dysplasia and special physical characteristics, and abnormal sex hormone, abnormal growth hormone, dyslipidemia, etc. This article summarized and analyzed the clinical characteristics and test results of a child with Turner syndrome, combined with literature review, in order to improve the understanding of Turner syndrome and clinical diagnosis and treatment.","PeriodicalId":507854,"journal":{"name":"International Journal of Biology and Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With the aggravation of environmental problems in livestock and poultry raising and the improvement of consumers' health awareness level, people keep looking for food products that can partially or completely replace animal-based meat products. Plant-based meat products are meat imitation products with similar texture, taste and flavor as traditional animal meat products, which are obtained by spinning, extruding and other key processing technologies using suitable plant proteins as raw materials. In this paper, we introduce the characteristics of common processing materials and types of plant-based meat products, elaborate on the nutritional and safety aspects of today's plant-based meat products, and discuss the challenges and opportunities facing the domestic plant-based meat products market. It aims to provide theoretical reference for the research and development of plant-based meat products in China.
{"title":"Plant-based Meat Products and Their Research and Development Progress","authors":"Jiawen Ning, Jiebiao Chen, Jianming Song, Jianxiong Zhang","doi":"10.54097/ijbls.v3i3.13","DOIUrl":"https://doi.org/10.54097/ijbls.v3i3.13","url":null,"abstract":"With the aggravation of environmental problems in livestock and poultry raising and the improvement of consumers' health awareness level, people keep looking for food products that can partially or completely replace animal-based meat products. Plant-based meat products are meat imitation products with similar texture, taste and flavor as traditional animal meat products, which are obtained by spinning, extruding and other key processing technologies using suitable plant proteins as raw materials. In this paper, we introduce the characteristics of common processing materials and types of plant-based meat products, elaborate on the nutritional and safety aspects of today's plant-based meat products, and discuss the challenges and opportunities facing the domestic plant-based meat products market. It aims to provide theoretical reference for the research and development of plant-based meat products in China.","PeriodicalId":507854,"journal":{"name":"International Journal of Biology and Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiwei Yuan, Siyu Yang, Huimin Wang, Wang Zhao, Yicheng Zhou
Objective: To report a case of cervical lymph node metastatic cancer in order to improve the understanding of this disease. Methods: To analyze the clinical features, clinical manifestations and risk factors of a case of cervical lymph node metastasis after operation of gingival squamous cell carcinoma. Results: Clinical features: The patient had a long clinical course and was diagnosed as "right cervical lymph node metastatic carcinoma", which was consistent with squamous cell carcinoma combined with morphology and history. Tissue: The tumor cells grew into nests and infiltrated, and the cell atypia was obvious, with keratinized beads and pathological mitosis. Immunohistochemistry: P63 (+), P40 (+), CK5/6 (+), P16 (-), Ki-67 hot spot index 40%. Conclusion: Cervical lymph is the aggregation area of the whole-body lymph; the whole-body lymph fluid can be drained through this. Pathology combined with immunohistochemical examination is the gold standard of diagnosis. The main treatment is surgical resection, combined with radiotherapy if necessary, and close follow-up after surgery.
{"title":"One Case of Cervical Lymph Node Metastasis was Reported","authors":"Yiwei Yuan, Siyu Yang, Huimin Wang, Wang Zhao, Yicheng Zhou","doi":"10.54097/ijbls.v3i3.14","DOIUrl":"https://doi.org/10.54097/ijbls.v3i3.14","url":null,"abstract":"Objective: To report a case of cervical lymph node metastatic cancer in order to improve the understanding of this disease. Methods: To analyze the clinical features, clinical manifestations and risk factors of a case of cervical lymph node metastasis after operation of gingival squamous cell carcinoma. Results: Clinical features: The patient had a long clinical course and was diagnosed as \"right cervical lymph node metastatic carcinoma\", which was consistent with squamous cell carcinoma combined with morphology and history. Tissue: The tumor cells grew into nests and infiltrated, and the cell atypia was obvious, with keratinized beads and pathological mitosis. Immunohistochemistry: P63 (+), P40 (+), CK5/6 (+), P16 (-), Ki-67 hot spot index 40%. Conclusion: Cervical lymph is the aggregation area of the whole-body lymph; the whole-body lymph fluid can be drained through this. Pathology combined with immunohistochemical examination is the gold standard of diagnosis. The main treatment is surgical resection, combined with radiotherapy if necessary, and close follow-up after surgery.","PeriodicalId":507854,"journal":{"name":"International Journal of Biology and Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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