Gul Nawaz, Qeswershah, Najeeb Ullah, Raz Mohammad, Mohammad Anwar Trezai, Saidraheemshah
Myocardial infarction, specifically ST elevation myocardial infarction (STEMI), involves the development of localized ischemic necrosis in the heart muscle due to an acute disruption of coronary blood flow. It clinically presents as burning, pressing, or squeezing chest pain that radiates to the left arm, collarbone, scapula, or jaw, along with symptoms such as shortness of breath, a feeling of fear, and cold sweat. Immediate hospitalization in a cardiac intensive care unit is crucial for patients with a developed myocardial infarction, as delays in treatment can be fatal. This study is a descriptive case series conducted in the year 1397 of the Islamic calendar. Out of 1602 inpatients admitted to Khost Postgraduate Hospital during this period, 50 patients were diagnosed with STEMI. The primary objectives of this research were to determine the frequency and pattern of STEMI cases at Khost Postgraduate Hospital during the year 1396 of the Islamic calendar.
{"title":"An Analysis of STEMI Cases in the Postgraduate Hospital in Khost, Afghanistan","authors":"Gul Nawaz, Qeswershah, Najeeb Ullah, Raz Mohammad, Mohammad Anwar Trezai, Saidraheemshah","doi":"10.55544/jrasb.3.3.26","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.26","url":null,"abstract":"Myocardial infarction, specifically ST elevation myocardial infarction (STEMI), involves the development of localized ischemic necrosis in the heart muscle due to an acute disruption of coronary blood flow. It clinically presents as burning, pressing, or squeezing chest pain that radiates to the left arm, collarbone, scapula, or jaw, along with symptoms such as shortness of breath, a feeling of fear, and cold sweat. Immediate hospitalization in a cardiac intensive care unit is crucial for patients with a developed myocardial infarction, as delays in treatment can be fatal. \u0000This study is a descriptive case series conducted in the year 1397 of the Islamic calendar. Out of 1602 inpatients admitted to Khost Postgraduate Hospital during this period, 50 patients were diagnosed with STEMI. \u0000The primary objectives of this research were to determine the frequency and pattern of STEMI cases at Khost Postgraduate Hospital during the year 1396 of the Islamic calendar.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sinusitis is one of the most common medical problems in children, caused by inflammation and infection in the nasal sinuses. This disease can have a significant impact on the growth and health of children. Investigating the factors affecting the prevalence of sinusitis in children is necessary in order to take appropriate preventive and therapeutic measures. In this regard, the present study aimed to investigate the factors affecting the prevalence of sinusitis among children referred to Abu Ali Sina Educational Hospital in Balkhi. Materials and Methods: This study includes the design of a prospective descriptive study, data were collected using patients' files, then by analyzing the data, the causes of the prevalence of sinusitis in children referred to Abu Ali Sina Balkhi Educational Hospital will be identified and the results will be presented in the form of a scientific article. The findings showed that the prevalence of sinusitis was higher among children admitted to Abu Ali Sina Educational Hospital in Balkhi and viral infections (influenza 20%, adenovirus 24% and Ronovirus 40%) were reported. The majority of patients had symptoms such as nasal congestion and discharge, a feeling of congestion in the ears, headache, and fever. In the majority of patients, their growth and development disorders have also been observed.
{"title":"Investigation of Factors Affecting the Prevalence of Sinusitis in Children Referred to Abu Ali Sina Balkhi Educational Hospital","authors":"Muhammad Sidiq Osmani","doi":"10.55544/jrasb.3.3.28","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.28","url":null,"abstract":"Sinusitis is one of the most common medical problems in children, caused by inflammation and infection in the nasal sinuses. This disease can have a significant impact on the growth and health of children. Investigating the factors affecting the prevalence of sinusitis in children is necessary in order to take appropriate preventive and therapeutic measures. In this regard, the present study aimed to investigate the factors affecting the prevalence of sinusitis among children referred to Abu Ali Sina Educational Hospital in Balkhi. Materials and Methods: This study includes the design of a prospective descriptive study, data were collected using patients' files, then by analyzing the data, the causes of the prevalence of sinusitis in children referred to Abu Ali Sina Balkhi Educational Hospital will be identified and the results will be presented in the form of a scientific article. The findings showed that the prevalence of sinusitis was higher among children admitted to Abu Ali Sina Educational Hospital in Balkhi and viral infections (influenza 20%, adenovirus 24% and Ronovirus 40%) were reported. The majority of patients had symptoms such as nasal congestion and discharge, a feeling of congestion in the ears, headache, and fever. In the majority of patients, their growth and development disorders have also been observed.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Moringa oleifera Lam., more commonly referred to as munga, is a plant that is widely cultivated in India and is used for medicinal purposes. In the family Moringaceae, it is classified as a member. The fact that this plant possesses a multitude of advantageous pharmacological effects, including as anti-diabetic, hepatoprotective, anti-inflammatory, anti-fertility, anti-cancer, anti-microbial, and antioxidant qualities, makes it an appealing nutritional herb. Different names for this species include the horse radish tree and the drumstick tree, to mention only two of them. Each and every part of this plant contains a component that can be utilised for medical purposes. Milk protein, vitamin A, and vitamin C are all found in high concentrations in this food. There are many different chemicals that are considered to be active phytoconstituents. These substances include proteins, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oils, and lipids. This plant also has a home in the tropical regions of the world. These are some extra components that are included: both niazinin A and niazinin B, as well as niazimicin A and niaziminin B. In the fight against malnutrition, the plant's high phytonutrient concentration makes it an effective natural integrator that complements other natural remedies. The findings of studies that investigated the phytochemistry of different plant parts have shown that plants contain a large quantity of organic molecules, which include both primary and secondary metabolites. After doing research on the pharmacological and nutraceutical properties of the plant, it has been determined that it can be utilised in the treatment of a variety of ailments. Through this review, the phytochemical composition of the plant, as well as its therapeutic applications and pharmacological effects, are discussed in depth.
Moringa oleifera Lam.，通常被称为 Munga，是一种在印度广泛种植并用于药用的植物。它属于桑科植物。事实上，这种植物具有多种有利的药理作用，包括抗糖尿病、保护肝脏、抗炎、抗生育、抗癌、抗微生物和抗氧化，因此是一种很有吸引力的营养草药。该物种的不同名称包括马萝卜树和鼓槌树，这里仅提及其中两种。这种植物的每一部分都含有可用于医疗目的的成分。牛奶蛋白、维生素 A 和维生素 C 在这种食物中含量都很高。有许多不同的化学物质被认为是活性植物成分。这些物质包括蛋白质、奎宁、皂甙、黄酮类、单宁、类固醇、苷、固定油和脂类。这种植物也生长在世界热带地区。在与营养不良作斗争的过程中，这种植物的高浓度植物营养素使其成为一种有效的天然集成剂，与其他天然疗法相辅相成。对不同植物部位的植物化学研究结果表明，植物含有大量有机分子，其中包括初级和次级代谢产物。在对植物的药理和营养保健特性进行研究后，确定它可用于治疗多种疾病。本综述将深入探讨该植物的植物化学成分及其治疗应用和药理作用。
{"title":"Pharmacological Activities, Phytochemistry and Traditional Uses of Moringa oleifera","authors":"Mihir Otia, Himanshi Chorotiya, Madhulika Krishan Yadav, Gavit Manoj Kashinath, Santosh Kumar, Prakash Pralhad, Sarwade, Soaib Ahmed, Devesh Avinash Machhi, M. Pharm","doi":"10.55544/jrasb.3.3.29","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.29","url":null,"abstract":"Moringa oleifera Lam., more commonly referred to as munga, is a plant that is widely cultivated in India and is used for medicinal purposes. In the family Moringaceae, it is classified as a member. The fact that this plant possesses a multitude of advantageous pharmacological effects, including as anti-diabetic, hepatoprotective, anti-inflammatory, anti-fertility, anti-cancer, anti-microbial, and antioxidant qualities, makes it an appealing nutritional herb. Different names for this species include the horse radish tree and the drumstick tree, to mention only two of them. Each and every part of this plant contains a component that can be utilised for medical purposes. Milk protein, vitamin A, and vitamin C are all found in high concentrations in this food. There are many different chemicals that are considered to be active phytoconstituents. These substances include proteins, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oils, and lipids. This plant also has a home in the tropical regions of the world. These are some extra components that are included: both niazinin A and niazinin B, as well as niazimicin A and niaziminin B. In the fight against malnutrition, the plant's high phytonutrient concentration makes it an effective natural integrator that complements other natural remedies. The findings of studies that investigated the phytochemistry of different plant parts have shown that plants contain a large quantity of organic molecules, which include both primary and secondary metabolites. After doing research on the pharmacological and nutraceutical properties of the plant, it has been determined that it can be utilised in the treatment of a variety of ailments. Through this review, the phytochemical composition of the plant, as well as its therapeutic applications and pharmacological effects, are discussed in depth.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Samiullah, Kajal Chauhan, Dr. K. Manimekalai, S. H. Sherief, Maulik K. Pandya, Soaib Ahmed, Roushan Bhaskar, Jay Prakash
Alzheimer's disease is a neurodegenerative disorder that ultimately results from the accumulation of beta-amyloid plaques in the brain. The Alzheimer's disease cannot be prevented or cured at this time, and there is no recognised alternative. The medicinal solutions that are currently available can merely slow down its development. However, nanotechnology has demonstrated its applications in the medical field, and it demonstrates a great deal of promise in the treatment of Alzheimer's disease. In particular, it has shown significant promise in the detection of the condition and the development of an alternative technique to cure it. It is necessary for the medication delivery system to have the capability of penetrating and crossing the blood-brain barrier in order to accomplish this need. On the other hand, greater research is necessary in order to discover and overcome these limitations, which have the potential to improve drug absorption while simultaneously reducing toxicity and adverse effects. Certain nanotechnology-based techniques to treating Alzheimer's disease include regenerative medicine, neuroprotection, and stem cell regeneration. These are just few of the emerging approaches. This article's goal is to take a look at nanotechnology from every angle, including its advantages and disadvantages and how it's helping with neurodegenerative disease research and therapy.
{"title":"Nanotechnology Based Therapeutic Approach in Alzheimer's","authors":"Md. Samiullah, Kajal Chauhan, Dr. K. Manimekalai, S. H. Sherief, Maulik K. Pandya, Soaib Ahmed, Roushan Bhaskar, Jay Prakash","doi":"10.55544/jrasb.3.3.24","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.24","url":null,"abstract":"Alzheimer's disease is a neurodegenerative disorder that ultimately results from the accumulation of beta-amyloid plaques in the brain. The Alzheimer's disease cannot be prevented or cured at this time, and there is no recognised alternative. The medicinal solutions that are currently available can merely slow down its development. However, nanotechnology has demonstrated its applications in the medical field, and it demonstrates a great deal of promise in the treatment of Alzheimer's disease. In particular, it has shown significant promise in the detection of the condition and the development of an alternative technique to cure it. It is necessary for the medication delivery system to have the capability of penetrating and crossing the blood-brain barrier in order to accomplish this need. On the other hand, greater research is necessary in order to discover and overcome these limitations, which have the potential to improve drug absorption while simultaneously reducing toxicity and adverse effects. Certain nanotechnology-based techniques to treating Alzheimer's disease include regenerative medicine, neuroprotection, and stem cell regeneration. These are just few of the emerging approaches. This article's goal is to take a look at nanotechnology from every angle, including its advantages and disadvantages and how it's helping with neurodegenerative disease research and therapy.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141672823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziarmal Mawla Khan, Qasimi Waliullah, Hairan Roshan, Ziarmal Awal Khan
The discovery of X-rays at the end of the 19th century led to a real breakthrough in the study of the structure of matter. X-rays, which belong to the group of electromagnetic waves, collide with the atoms of solid matter depending on their wavelength and energy, therefore, their three-dimensional interference occurs in the structure of a crystal lattice. When such radiation is incident on a crystal, a complex pattern of radiation is created which reflects the crystal structure. In this section, the charging of the entire crystal lattice is studied during collision with a specific atom in the crystal lattice.
{"title":"Study of Charged States During X-Ray Interference in Crystalline Lattices","authors":"Ziarmal Mawla Khan, Qasimi Waliullah, Hairan Roshan, Ziarmal Awal Khan","doi":"10.55544/jrasb.3.3.23","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.23","url":null,"abstract":"The discovery of X-rays at the end of the 19th century led to a real breakthrough in the study of the structure of matter. X-rays, which belong to the group of electromagnetic waves, collide with the atoms of solid matter depending on their wavelength and energy, therefore, their three-dimensional interference occurs in the structure of a crystal lattice. When such radiation is incident on a crystal, a complex pattern of radiation is created which reflects the crystal structure. In this section, the charging of the entire crystal lattice is studied during collision with a specific atom in the crystal lattice.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kundan Kumar Kushwaha, Rita Saini, Shivanand Patil
Introduction: Cranberry (Vaccinium Macrocarpon) is one of the extremely accessible conventionally used herbal plants with various biological activities. However, actions of Cranberry on antioxidant properties and chemically investigated for its phytoconstituents in the current studied. Therefore, the scope of the current exploration is to screen the antioxidant effects of leaf extracts. Materials and Methods: The antioxidant activity (in vitro) was assessed with UV Spectroscopic. Hydrogen peroxide (free radical) scavenging methods were employed to check the in vitro antioxidant property. Result: Plant methanol, Ether and Distilled water extract had a substantial impact on the hydrogen peroxide radical activity of scavenging and less effects than the standard radical activity and the bioactive compound like flavanoids, tannins and glycosides were shown to be positive. Conclusion: These findings suggested that the plant leaves are comprised of significant antioxidant properties. It could be a promising source for the existence of antioxidant properties and other therapeutic agents.
{"title":"Evaluation of the Antioxidant Activity of a Leaf Extract of Cranberry (Vaccinium macrocarpon)","authors":"Kundan Kumar Kushwaha, Rita Saini, Shivanand Patil","doi":"10.55544/jrasb.3.3.13","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.13","url":null,"abstract":"Introduction: Cranberry (Vaccinium Macrocarpon) is one of the extremely accessible conventionally used herbal plants with various biological activities. However, actions of Cranberry on antioxidant properties and chemically investigated for its phytoconstituents in the current studied. Therefore, the scope of the current exploration is to screen the antioxidant effects of leaf extracts. \u0000Materials and Methods: The antioxidant activity (in vitro) was assessed with UV Spectroscopic. Hydrogen peroxide (free radical) scavenging methods were employed to check the in vitro antioxidant property. \u0000Result: Plant methanol, Ether and Distilled water extract had a substantial impact on the hydrogen peroxide radical activity of scavenging and less effects than the standard radical activity and the bioactive compound like flavanoids, tannins and glycosides were shown to be positive. \u0000Conclusion: These findings suggested that the plant leaves are comprised of significant antioxidant properties. It could be a promising source for the existence of antioxidant properties and other therapeutic agents.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Incontinence is a physical disability that is associated with social isolation and leads to anxiety, depression and reduced self-confidence. This disease is a common medical problem that may have adverse effects on their quality of life and social relationships. This descriptive-cross-sectional study was conducted in Mazar-e-Sharif in 1400-1401. The statistical population of this research consists of all women referring to Hakimi hospital. The samples included 100 women with the age of 40-60 years who had visited the hospital with various complaints including urinary incontinence. Sampling was simple random and 79 people were selected using Morgan's table. The data was collected with the help of a questionnaire and then entered into the SPSS 28 software for analysis. The findings show that among the (79) respondents, (39) respondents were between 40-50 years old, and (40) respondents were between 50-60 years old. (20) between the ages of 60-70 kg, (29) between 70-90 kg and (30) more than 90 kg. Among the patients, (12) had given birth 1-2 times, (28) had a normal birth and (34) had a non-normal birth (cesarean section). The average and standard deviation of the age of the participants was 80.5 ± 5.41 years, the average weight was 90.13 ± 12.98 kilograms, the average number of births was 4.23 ± 1.82, the average number of normal births was 3.42 ± 3.82, and the average number of non-normal or cesarean births was 29.16 ± 4.28. Urinary incontinence type was observed in (12) forte (15%), (44) combined (56%), (10) continuous (10%) and stress (13) tons (16%). The findings show that among the prevalence factors among patients, home birth (38%) and diabetes (25.4%) are among the most common causes of urinary incontinence among women. There was also a significant relationship between the use of contraceptives and incontinence. In the present study, there was a statistically significant relationship between age and suffering from administrative incontinence.
{"title":"Investigating the Prevalence of Urinary Incontinence among Women in Northern Afghanistan","authors":"Abdul Ali Yaqubi, Abdul Qayum Hakimi, Qais Afzali","doi":"10.55544/jrasb.3.3.9","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.9","url":null,"abstract":"Incontinence is a physical disability that is associated with social isolation and leads to anxiety, depression and reduced self-confidence. This disease is a common medical problem that may have adverse effects on their quality of life and social relationships. This descriptive-cross-sectional study was conducted in Mazar-e-Sharif in 1400-1401. The statistical population of this research consists of all women referring to Hakimi hospital. The samples included 100 women with the age of 40-60 years who had visited the hospital with various complaints including urinary incontinence. Sampling was simple random and 79 people were selected using Morgan's table. The data was collected with the help of a questionnaire and then entered into the SPSS 28 software for analysis. The findings show that among the (79) respondents, (39) respondents were between 40-50 years old, and (40) respondents were between 50-60 years old. (20) between the ages of 60-70 kg, (29) between 70-90 kg and (30) more than 90 kg. Among the patients, (12) had given birth 1-2 times, (28) had a normal birth and (34) had a non-normal birth (cesarean section). The average and standard deviation of the age of the participants was 80.5 ± 5.41 years, the average weight was 90.13 ± 12.98 kilograms, the average number of births was 4.23 ± 1.82, the average number of normal births was 3.42 ± 3.82, and the average number of non-normal or cesarean births was 29.16 ± 4.28. Urinary incontinence type was observed in (12) forte (15%), (44) combined (56%), (10) continuous (10%) and stress (13) tons (16%). The findings show that among the prevalence factors among patients, home birth (38%) and diabetes (25.4%) are among the most common causes of urinary incontinence among women. There was also a significant relationship between the use of contraceptives and incontinence. In the present study, there was a statistically significant relationship between age and suffering from administrative incontinence.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141338030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The special qualities of microsponges are making them a promising drug delivery system. These cross-linked, highly porous polymer particles have the capacity to encapsulate and release medications in a regulated fashion. Microsponges can effectively entrap both hydrophilic and hydrophobic drugs, improving their stability and preventing drug degradation, thanks to their large internal surface area and adjustable pore sizes. Innovative drug delivery devices known as microsponges have drawn a lot of interest from the pharmaceutical industry. The controlled and sustained release of medications is made possible by these porous, polymeric structures, which also minimise side effects and increase patient compliance. These systems also provide regulated release kinetics, which enhance bioavailability and minimise adverse effects. Because microsponges can be used topically or orally, they can be used for a wide range of therapeutic purposes. The potential of microsponges as adaptable drug delivery devices that could completely change the pharmaceutical formulation industry.
{"title":"A Comprehensive Review on Microsponges Drug Delivery Systems","authors":"Sandesh Sah, Arti Kohri, Shivanand Patil","doi":"10.55544/jrasb.3.3.11","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.11","url":null,"abstract":"The special qualities of microsponges are making them a promising drug delivery system. These cross-linked, highly porous polymer particles have the capacity to encapsulate and release medications in a regulated fashion. Microsponges can effectively entrap both hydrophilic and hydrophobic drugs, improving their stability and preventing drug degradation, thanks to their large internal surface area and adjustable pore sizes. Innovative drug delivery devices known as microsponges have drawn a lot of interest from the pharmaceutical industry. The controlled and sustained release of medications is made possible by these porous, polymeric structures, which also minimise side effects and increase patient compliance. These systems also provide regulated release kinetics, which enhance bioavailability and minimise adverse effects. Because microsponges can be used topically or orally, they can be used for a wide range of therapeutic purposes. The potential of microsponges as adaptable drug delivery devices that could completely change the pharmaceutical formulation industry.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141342586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Salvia Rosemary is a medicinal herb of great importance for traditional applications against several kinds of disease. Because of the range of bioactive compounds, the genus of Salvia Rosemary is regarded as one of the most significant genus utilised in many medical systems. This plant was chemically investigated for its bioactive compounds in the current analysis. Materials and Methods: The essential oil of Rosemary extract by using clevenger apparatus with the help of distillation method. Result: The anti-microbial gel was evaluated for appearance and homogeneity, grittiness, pH, viscosity, particle size etc. The anti-microbial gel was white in colour which feels smooth on application and have aromatic odour. The antimicrobial activity of herbal gel was compared with standard and it’s found to be less effective. Conclusion: It was inferred from the result that anti-microbial gel was good in appearance, homogeniety and easily spreadable. The anti-microbial gel was prepared using gelling agent like carbopol 934 along with polyethylene glycol and the formulation were subjected to various evaluation parameters. The pH of all three formulations were in the range of the pH of the skin. The Antimicrobial gel was less effective then standard gel as they have rosemary oil and lavender oil as their key ingredients because of their anti-microbial property.
{"title":"Evaluation and Formulation of Anti-Microbial Gel Using Lavender Oil and Rosemary Oil","authors":"Sunil Gupta","doi":"10.55544/jrasb.3.3.14","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.14","url":null,"abstract":"Introduction: Salvia Rosemary is a medicinal herb of great importance for traditional applications against several kinds of disease. Because of the range of bioactive compounds, the genus of Salvia Rosemary is regarded as one of the most significant genus utilised in many medical systems. This plant was chemically investigated for its bioactive compounds in the current analysis. \u0000Materials and Methods: The essential oil of Rosemary extract by using clevenger apparatus with the help of distillation method. \u0000Result: The anti-microbial gel was evaluated for appearance and homogeneity, grittiness, pH, viscosity, particle size etc. The anti-microbial gel was white in colour which feels smooth on application and have aromatic odour. The antimicrobial activity of herbal gel was compared with standard and it’s found to be less effective. \u0000Conclusion: It was inferred from the result that anti-microbial gel was good in appearance, homogeniety and easily spreadable. The anti-microbial gel was prepared using gelling agent like carbopol 934 along with polyethylene glycol and the formulation were subjected to various evaluation parameters. The pH of all three formulations were in the range of the pH of the skin. The Antimicrobial gel was less effective then standard gel as they have rosemary oil and lavender oil as their key ingredients because of their anti-microbial property.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141341856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clerodendrum infortunatum is also known as hill glory bower. Clerodendrum infortunatum plants are widely distributed throughout the whole world. Up to now, many species of C. infortunatum have been described in various indigenous systems of medicine that are used in preparation of folklore medicines for the treatment of various life-threatening disease, and more of the Clerodendrum infortunatum have been very well studied for their chemical constituents and biological activities It also used in Unani, Ayurveda, and siddha system of medicine for many years. In the Clerodendrum Infortunatum many compounds, including monoterpentine and its derivatives, sesquiterpene, di-terpenoids, tri-terpentine, flavonoid, quercetin, acacetin, gallic acid, sterols and flavonoid glycoside, phenylethanoid glycoside, steroids and steroid glycosides, cyclohexylethanoids, anthraqunine, cyanogenic glycosides, and others have been isolated and identified. In the present study, Chloroform, pet.ether, and water stem extract Clerodendrum infortunatum obtained by Soxhlet extraction was screened to detect the presence or absence of several bioactive compounds which are reported to cure different diseases. Anti-microbial analysis of stem extract was carried out against lacto-bacillus, E.coli and staphylococcus aureus organisms by agar well diffusion method.It was observed that the zone was recorded against this organism. The results indicates that the chloroform, pet.ether and water extract of C. infortunatum is having anti- microbial efficiency in controlling the microorganisms. So, clerodendrum infortunatum is the plant which are benificial on human health.
{"title":"Qualitative Investigation and Screening of Antimicrobial Activity of Stem Extract of Clerodendrum Infortunatum Plant","authors":"Dipendra Singh, Rita Saini, Shivanand Patil","doi":"10.55544/jrasb.3.3.12","DOIUrl":"https://doi.org/10.55544/jrasb.3.3.12","url":null,"abstract":"Clerodendrum infortunatum is also known as hill glory bower. Clerodendrum infortunatum plants are widely distributed throughout the whole world. Up to now, many species of C. infortunatum have been described in various indigenous systems of medicine that are used in preparation of folklore medicines for the treatment of various life-threatening disease, and more of the Clerodendrum infortunatum have been very well studied for their chemical constituents and biological activities It also used in Unani, Ayurveda, and siddha system of medicine for many years. In the Clerodendrum Infortunatum many compounds, including monoterpentine and its derivatives, sesquiterpene, di-terpenoids, tri-terpentine, flavonoid, quercetin, acacetin, gallic acid, sterols and flavonoid glycoside, phenylethanoid glycoside, steroids and steroid glycosides, cyclohexylethanoids, anthraqunine, cyanogenic glycosides, and others have been isolated and identified. In the present study, Chloroform, pet.ether, and water stem extract Clerodendrum infortunatum obtained by Soxhlet extraction was screened to detect the presence or absence of several bioactive compounds which are reported to cure different diseases. Anti-microbial analysis of stem extract was carried out against lacto-bacillus, E.coli and staphylococcus aureus organisms by agar well diffusion method.It was observed that the zone was recorded against this organism. The results indicates that the chloroform, pet.ether and water extract of C. infortunatum is having anti- microbial efficiency in controlling the microorganisms. So, clerodendrum infortunatum is the plant which are benificial on human health.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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