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COPD treatment ratio: a measure for improving COPD population health. 慢性阻塞性肺疾病治疗比率:改善慢性阻塞性肺疾病人群健康的衡量标准。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-09-01 DOI: 10.37765/ajmc.2024.89603
Megha A Parikh, Sabree C Burbage, Meghan H Gabriel, Ben E Shirley, Patrick J Campbell

Objectives: Despite chronic obstructive pulmonary disease (COPD) being a leading cause of death in the US, there are few COPD measures in current quality programs. The objective of this study was to assess the validity and applicability of the COPD treatment ratio (CTR) as a surrogate marker of COPD exacerbation risk for use in quality measurement. CTR is defined as the ratio of COPD maintenance medications to all COPD medications (maintenance and rescue).

Study design: This retrospective cohort study used 2016-2019 administrative claims from Optum Clinformatics Data Mart to evaluate CTR values over a 12-month baseline period, with exacerbations measured the following year. Patients 40 years or older with Medicare Advantage or commercial insurance and with a COPD diagnosis were included.

Methods: Logistic regression models were used to examine relationships between CTR values and COPD exacerbations. Prediction model performance was evaluated using C statistics, and receiver operating characteristics were used to determine the optimal cut point for CTR.

Results: Of 132,960 patients included in the analysis, 79.5% were Medicare Advantage beneficiaries, and the mean age was 69.6 years. Higher CTR values were significantly associated with reduced risk of any, moderate, and severe exacerbations in the total population and when stratified by insurance type. CTR performed fairly to moderately well in predicting COPD exacerbations. The optimal cut point for COPD exacerbation prediction was 0.7.

Conclusions: Study results substantiated CTR as a valid measure of COPD exacerbation risk and support the use of CTR in quality improvement to drive evidence-based care for individuals with COPD.

目标:尽管慢性阻塞性肺病(COPD)是美国人的主要死因,但目前的质量计划中却很少有慢性阻塞性肺病的测量指标。本研究旨在评估慢性阻塞性肺疾病治疗比率(CTR)作为慢性阻塞性肺疾病恶化风险替代指标在质量测量中的有效性和适用性。CTR 的定义是慢性阻塞性肺病维持治疗药物与所有慢性阻塞性肺病药物(维持治疗和抢救治疗)的比率:这项回顾性队列研究使用 Optum Clinformatics Data Mart 提供的 2016-2019 年行政索赔来评估 12 个月基线期内的 CTR 值,并在次年测量病情加重情况。研究对象包括 40 岁及以上、拥有医疗保险优势或商业保险、诊断为慢性阻塞性肺病的患者:方法:使用逻辑回归模型来检验 CTR 值与慢性阻塞性肺病恶化之间的关系。结果:在纳入的 132,960 名患者中,有 132,960 人患有慢性阻塞性肺病:在纳入分析的 132960 名患者中,79.5% 为医疗保险优势受益人,平均年龄为 69.6 岁。在全部人群中,以及按保险类型分层时,较高的 CTR 值与任何、中度和重度病情恶化风险的降低有明显关联。CTR 在预测慢性阻塞性肺疾病加重方面的表现为中上等。预测慢性阻塞性肺疾病加重的最佳切点为 0.7:研究结果证明,CTR 是衡量慢性阻塞性肺疾病恶化风险的有效指标,并支持在质量改进中使用 CTR 来推动对慢性阻塞性肺疾病患者的循证护理。
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引用次数: 0
Telehealth insights from an integrated care system. 来自综合医疗系统的远程医疗见解。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-09-01 DOI: 10.37765/ajmc.2024.89609
Rebecca Flournoy, Reema Shah, Elizabeth Moisan, Cecilia Oregón

The COVID-19 pandemic accelerated telehealth expansion trends as policy makers instituted flexibilities and coverage changes. Federal telehealth flexibilities expire, however, at the end of 2024. To decide whether to extend those flexibilities, policy makers need information about consumer telehealth preferences, impacts of telehealth on care usage and quality, and telehealth accessibility for the full diversity of patients. Research from one of the nation's largest integrated, value-based health systems provides insights. Findings suggest that telehealth utilization has dropped since the peak of the pandemic but remains higher than prepandemic levels. Telehealth appears to be replacing in-person visits rather than leading to more total visits. Patients generally prefer in-person care but many like having the option to use video- and phone-based telehealth, and both video- and phone-based care appear to be helping patients access primary care. An integrated, value-based care approach may assist a diverse range of patients in accessing telehealth services. Action is still needed, however, to ensure that the full diversity of patients can easily access telehealth offerings. Based on experiences within our health system, we recommend that policy makers maintain public and private payer coverage for video- and phone-based telehealth services; encourage well-designed value-based payment models to simplify and expand telehealth access; improve broadband accessibility and broadband and device affordability so that all patients can access telehealth services; and hold digital health to equivalent high standards for care quality, safety, patient satisfaction, clinical outcomes, and health equity as in-person care.

COVID-19 大流行加速了远程医疗的扩展趋势,因为政策制定者制定了灵活的政策并改变了覆盖范围。然而,联邦远程医疗灵活性将于 2024 年底到期。要决定是否延长这些灵活性,政策制定者需要了解消费者的远程医疗偏好、远程医疗对医疗使用和质量的影响以及远程医疗对所有患者的可及性。来自美国最大的以价值为基础的综合医疗系统之一的研究提供了深刻的见解。研究结果表明,自疫情高峰期以来,远程医疗的使用率有所下降,但仍高于疫情爆发前的水平。远程医疗似乎正在取代面对面就诊,而不是带来更多的就诊总量。患者一般更喜欢亲自就诊,但许多人喜欢选择使用视频和电话远程保健,视频和电话保健似乎都有助于患者获得初级保健。以价值为基础的综合护理方法可以帮助不同的患者获得远程保健服务。但仍需采取行动,确保所有患者都能轻松获得远程医疗服务。根据我们医疗系统的经验,我们建议政策制定者维持公共和私人支付方对基于视频和电话的远程医疗服务的覆盖;鼓励设计良好的基于价值的支付模式,以简化和扩大远程医疗的使用;提高宽带的可及性以及宽带和设备的可负担性,从而使所有患者都能获得远程医疗服务;在医疗质量、安全性、患者满意度、临床结果和健康公平方面,要求数字医疗达到与现场医疗同等的高标准。
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引用次数: 0
Systemic treatments for advanced prostate cancer: relationship between health insurance plan and treatment costs. 晚期前列腺癌的系统治疗:医疗保险计划与治疗费用之间的关系。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-09-01 DOI: 10.37765/ajmc.2024.89606
Deborah R Kaye, Hui-Jie Lee, Alexander Gordee, Daniel J George, Charles D Scales, Peter A Ubel, M Kate Bundorf

Objectives: The high costs of cancer care can cause significant harm to patients and society. Prostate cancer, the leading nonskin malignancy in men, is responsible for the second-highest out-of-pocket (OOP) payments among all malignancies. Multiple first-line treatment options exist for metastatic castration-resistant prostate cancer (mCRPC); although their costs vary substantially, comparative effectiveness data are limited. There is little evidence of how gross payments made by insurers and OOP payments made by patients differ by treatment and health plan type and how these payment differences relate to utilization.

Study design: Retrospective cohort study.

Methods: We used IBM MarketScan databases from 2013-2019 to identify men with prostate cancer who initiated treatment with 1 of 6 drugs approved for first-line treatment of mCRPC. We calculated and compared gross and OOP payments and drug utilization across drug and insurance plan types.

Results: We identified 4298 patients who met our inclusion criteria. Insurer payments varied substantially by first-line therapy but were similar across different health plan types, except for docetaxel. OOP payments for a given first-line therapy, in contrast, varied by health plan type. Utilization of first-line therapies varied by plan type in unadjusted analyses, but not after adjusting for patient characteristics.

Conclusions: The extent to which patient OOP payments for drugs reflect differences in gross payments made by insurers varies across health insurance plan types. However, even though OOP payments for the same treatment differ across plan types, treatment choice is not significantly different across type of health insurance after controlling for patient characteristics.

目标:癌症治疗的高昂费用会对患者和社会造成巨大伤害。前列腺癌是男性最主要的非皮肤恶性肿瘤,其自付费用(OOP)在所有恶性肿瘤中位居第二。对于转移性抗性前列腺癌(mCRPC),有多种一线治疗方案可供选择;虽然这些方案的成本差异很大,但比较效果数据却很有限。几乎没有证据表明保险公司支付的总费用和患者支付的OOP费用在治疗和医疗计划类型上有何不同,以及这些支付差异与使用情况有何关系:研究设计:回顾性队列研究:我们使用 2013-2019 年间的 IBM MarketScan 数据库来识别患有前列腺癌的男性患者,他们开始使用获批用于 mCRPC 一线治疗的 6 种药物中的 1 种进行治疗。我们计算并比较了不同药物和保险计划类型的总费用、OOP 费用和药物使用情况:我们确定了 4298 名符合纳入标准的患者。除多西他赛外,不同类型的医疗保险计划对一线治疗的支付额差异很大,但都很相似。相比之下,特定一线疗法的自付费用则因医疗计划类型而异。在未经调整的分析中,一线疗法的使用率因计划类型而异,但在调整患者特征后则没有变化:结论:在不同类型的医疗保险计划中,患者的 OOP 药费在多大程度上反映了保险公司总药费的差异。然而,尽管不同类型的医保计划对相同治疗的 OOP 支付额度不同,但在控制了患者特征后,不同类型的医保计划对治疗的选择并无显著差异。
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引用次数: 0
The feasibility and equity of text messaging to determine patient eligibility for lung cancer screening. 用短信确定患者是否符合肺癌筛查条件的可行性和公平性。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-09-01 DOI: 10.37765/ajmc.2024.89602
Ilona Fridman, Lisa Carter-Bawa, Christine M Neslund-Dudas, Jennifer Elston Lafata

Objectives: Text messaging could be effective for determining patient eligibility for lung cancer screening (LCS). We explored people's willingness to share their tobacco use history via text message among diverse groups.

Study design: Cross-sectional survey.

Methods: In 2020, we conducted a cross-sectional survey asking respondents about cellular phone usage, smoking habits, sociodemographic characteristics, and the likelihood of responding to a text message from their health care provider's office about tobacco use. We used χ² and analysis of variance tests for comparisons.

Results: Among 745 respondents, 90% used text messaging casually. Overall, 54% never smoked, 33% currently smoked, and 13% previously smoked. Six percent were LCS eligible, and 20% used both cigarettes and e-cigarettes (dual users). Current smokers were significantly younger, less likely to be female, and more likely to use text messaging. LCS-eligible respondents were older and less likely to have a high income. Dual users were younger, less likely to report female gender and live in rural areas, and more likely to have a college education and high income. Most respondents (83%) indicated they were likely to respond to text message inquiries regarding smoking status. Middle-aged respondents (mean age, 37 years) were significantly more willing to report smoking status than younger or older respondents (91% vs 84% and 84%, respectively). Respondents with no college education (83% vs 88%) or with a low income vs a middle or high income (81% vs 86% and 88%, respectively) were significantly less willing to report smoking status via text messages.

Conclusions: Text messaging showed promise for evaluating smoking history and for simplifying the process of identifying LCS-eligible individuals. However, achieving equity in identifying eligibility for LCS requires the implementation of multimodal strategies.

目的:短信可有效确定患者是否符合肺癌筛查(LCS)的条件。我们探讨了不同群体中人们通过短信分享烟草使用史的意愿:研究设计:横断面调查:2020 年,我们进行了一项横断面调查,询问受访者的手机使用情况、吸烟习惯、社会人口学特征以及回复医疗服务提供者办公室发送的烟草使用短信的可能性。我们使用χ²和方差分析进行了比较:在745名受访者中,90%的人随意使用短信。总体而言,54%的受访者从不吸烟,33%的受访者目前吸烟,13%的受访者以前吸烟。6%的受访者符合长期吸烟条件,20%的受访者同时使用香烟和电子烟(双重使用者)。目前吸烟的受访者明显更年轻,女性比例更低,使用短信的比例更高。符合 LCS 资格的受访者年龄较大,不太可能有高收入。双重使用者更年轻,报告性别为女性和居住在农村地区的可能性较小,而受过大学教育和收入较高的可能性较大。大多数受访者(83%)表示他们可能会回复有关吸烟状况的短信询问。中年受访者(平均年龄 37 岁)报告吸烟状况的意愿明显高于年轻或年长的受访者(分别为 91% 对 84% 和 84%)。未受过大学教育(83% 对 88%)或低收入对中高收入(81% 对 86% 和 88%)的受访者通过短信报告吸烟状况的意愿明显较低:结论:短信在评估吸烟史和简化识别符合长期护理服务资格的个人的过程方面显示出前景。然而,要实现公平地确定是否符合 LCS 的条件,需要实施多模式策略。
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引用次数: 0
It's time to address our nation's health care price crisis. 是时候解决我国的医疗价格危机了。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-09-01 DOI: 10.37765/ajmc.2024.89598
Guy D'Andrea, Torie Nugent-Peterson

High health care prices cause significant harm to individuals, businesses, communities, and society at large. These harms include reduced access to care, rising medical debt, lower wages, more inequity, and a growing burden on businesses and governments. Despite widespread recognition of the issue, there has been insufficient action to address it effectively. Catalyst for Payment Reform and the Employers' Forum of Indiana's new campaign, Price Crisis, will mobilize individuals, employers, and policy makers with evidence, guidance, and resources to take meaningful actions through marketplace initiatives, policy advocacy, and antitrust enforcement. The following article is written from the perspective of Catalyst for Payment Reform.

高昂的医疗价格对个人、企业、社区和整个社会都造成了巨大的伤害。这些危害包括获得医疗服务的机会减少、医疗债务增加、工资降低、不公平加剧以及企业和政府的负担加重。尽管人们普遍认识到了这一问题,但却没有采取足够的行动来有效解决这一问题。支付改革催化剂 "和 "印第安纳州雇主论坛 "的新活动 "价格危机 "将动员个人、雇主和政策制定者,提供证据、指导和资源,通过市场倡议、政策倡导和反托拉斯执法采取有意义的行动。以下文章从支付改革促进会的角度撰写。
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引用次数: 0
The accelerated approval program for oncology drugs: celebrating more than 250,000 life-years gained and counting. 肿瘤药物加速审批计划:庆祝超过 25 万个生命年的增长。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-01 DOI: 10.37765/ajmc.2024.89590
Julie Patterson, John Michael O'Brien, Jonathan D Campbell

This commentary explores how 2 recently published studies evaluating the clinical benefit of the FDA's accelerated approval program for oncology drugs came to different conclusions.

这篇评论探讨了最近发表的两份研究报告是如何得出不同结论的,这两份研究报告评估了美国食品及药物管理局的肿瘤药物加速审批计划的临床效益。
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引用次数: 0
Geographic variability of Medicaid acceptance among allergists in the US. 美国过敏症医生接受医疗补助的地域差异。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-01 DOI: 10.37765/ajmc.2024.89588
Frances O Ho, Chaoyi Zheng, Mech Frazier, Sai R Nimmagadda, Ruchi S Gupta, Lucy A Bilaver

Objective: To determine the geographic variability of Medicaid acceptance among allergists in the US.

Study design: Geospatial analysis predicted Medicaid acceptance across space, and a multivariable regression identified area-level population demographic variables associated with acceptance.

Methods: We used the National Plan & Provider Enumeration System database to identify allergists. Medicaid acceptance was determined from lists or search engines from state Medicaid offices and calls to provider offices. Spatial analysis was performed using the empirical Bayesian kriging tool. Multivariate logistic regression was used to identify county-level characteristics associated with provider Medicaid acceptance.

Results: Of 5694 allergists, 55.5% accepted Medicaid. Acceptance in each state ranged from 13% to 90%. Washington, Arizona, and the Northeast had lowest predicted proportion of both Medicaid acceptance and Medicaid acceptance per 10,000 enrollees. Overall, county-level characteristics were not associated with the likelihood of accepting Medicaid in multivariate analyses. Only the percentage of individuals living in poverty was associated with a higher likelihood of providers accepting Medicaid (OR, 1.245; 95% CI, 1.156-1.340; P < .001).

Conclusions: A barrier to accessing allergy-related health care is finding a provider who accepts a patient's insurance, which is largely variable by state. Lack of access to allergy care likely affects health outcomes for children with prevalent atopic conditions such as food allergy.

目的:确定美国过敏症医生接受医疗补助的地域差异:研究设计:通过地理空间分析预测不同空间的医疗补助接受度,并通过多变量回归确定与接受度相关的地区人口变量:研究设计:通过地理空间分析预测不同空间的医疗补助接受度,并通过多变量回归确定与接受度相关的地区级人口统计学变量:方法:我们使用国家计划和提供商查点系统数据库来识别过敏症医生。根据各州医疗补助办公室的列表或搜索引擎以及对医疗服务提供者办公室的电话访问,确定了医疗补助的接受度。使用经验贝叶斯克里金工具进行了空间分析。多变量逻辑回归用于确定与医疗补助接受度相关的县级特征:在 5694 名过敏症医生中,55.5% 接受医疗补助。各州的接受度从 13% 到 90% 不等。华盛顿州、亚利桑那州和东北部的医疗补助接受率和每 10,000 名参保者中医疗补助接受率的预测比例均最低。总体而言,在多变量分析中,县级特征与接受《医疗补助计划》的可能性无关。只有贫困人口的比例与医疗服务提供者接受医疗补助的可能性较高有关(OR,1.245;95% CI,1.156-1.340;P <.001):获得过敏相关医疗服务的障碍之一是找到接受患者保险的医疗服务提供者,而这在很大程度上因州而异。无法获得过敏医疗服务可能会影响患有食物过敏等过敏性疾病的儿童的健康状况。
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引用次数: 0
Cross-validation of insurer and hospital price transparency data. 保险公司和医院价格透明度数据的交叉验证。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-01 DOI: 10.37765/ajmc.2024.89594
Morgan A Henderson, Morgane C Mouslim

Given recent congressional interest in codifying price transparency regulations, it is important to understand the extent to which newly available price transparency data capture true underlying procedure-level prices. To that end, we compared the prices for maternity services negotiated between a large payer and 26 hospitals in Mississippi across 2 separate price transparency data sources: payer and hospital. The degree of file overlap is low, with only 16.3% of hospital-billing code observations appearing in both data sources. However, for the observations that overlap, pricing concordance is high: Corresponding prices have a correlation coefficient of 0.975, 77.4% match to the penny, and 84.4% are within 10%. Exact price matching rates are greater than 90% for 3 of the 4 service lines included in this study. Taken together, these results suggest that although administrative misalignment exists between payers and hospitals, there is a measure of signal amid the price transparency noise.

鉴于近期国会对编纂价格透明度法规的兴趣,了解新获得的价格透明度数据在多大程度上反映了真实的基本手术价格就显得尤为重要。为此,我们比较了一家大型支付方与密西西比州 26 家医院在支付方和医院这两个独立的价格透明数据源之间协商的产科服务价格。文件重叠程度很低,只有 16.3% 的医院账单代码观测值同时出现在两个数据源中。然而,对于重叠的观察结果,定价的一致性很高:对应价格的相关系数为 0.975,77.4% 匹配,84.4% 在 10%以内。在本研究包括的 4 个服务项目中,有 3 个项目的精确价格匹配率超过 90%。综上所述,这些结果表明,虽然支付方和医院之间存在行政错位,但在价格透明度的噪音中仍有一定的信号。
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引用次数: 0
Hospitals' strategies to reduce costs and improve quality: survey of hospital leaders. 医院降低成本和提高质量的策略:对医院领导的调查。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-01 DOI: 10.37765/ajmc.2024.89593
Gmerice Hammond, Tierney Lanter, Fengxian Wang, R J Waken, Jie Zheng, Arnold M Epstein, E John Orav, Karen E Joynt Maddox

Objectives: Hospitals in the US operate under various value-based payment programs, but little is known regarding the strategies they use in this context to improve quality and reduce costs, overall or in voluntary programs including Bundled Payments for Care Improvement Advanced (BPCI-A).

Study design: A survey was administered to hospital leaders at 588 randomly selected acute care hospitals, with oversampling of BPCI-A participants, from November 2020 to June 2021. Twenty strategies and 20 barriers were queried in 4 domains: inpatient, postacute, outpatient, and community resources for vulnerable patients.

Methods: Summary statistics were tabulated, and responses were adjusted for sampling strategy and nonresponse.

Results: There were 203 respondents (35%), of which 159 (78%) were BPCI-A participants and 44 (22%) were nonparticipants. On average, respondents reported implementing 89% of queried strategies in the inpatient domain, such as care pathways or predictive analytics; 65% of postacute strategies, such as forming partnerships with skilled nursing facilities; 84% of outpatient strategies, such as scheduling close follow-up to prevent emergency department visits/hospitalizations; and 82% of strategies aimed at high-risk populations, such as building connections with community resources. There were no differences between BPCI-A and non-BPCI-A hospitals in 19 of 20 care redesign strategies queried. However, 78.3% of BPCI-A-participating hospitals reported programs aimed at reducing utilization of skilled nursing and inpatient rehabilitation facilities compared with 37.6% of non-BPCI-A hospitals (P < .0001).

Conclusions: Hospitals pursue a broad range of efforts to improve quality. BPCI-A hospitals have attempted to reduce use of postacute care, but otherwise the strategies they pursue are similar to other hospitals.

目标:美国的医院在各种基于价值的支付计划下运营,但对于医院在此背景下为提高质量和降低成本而采用的策略,无论是整体策略还是包括 "改善医疗服务捆绑支付高级计划"(BPCI-A)在内的自愿性计划,人们知之甚少:研究设计:2020 年 11 月至 2021 年 6 月期间,对随机抽取的 588 家急症护理医院的医院领导进行了调查,其中包括 BPCI-A 参与者。共调查了 4 个领域中的 20 项策略和 20 项障碍:住院患者、急性期后患者、门诊患者和弱势患者的社区资源:方法:列出简要统计数据,并根据抽样策略和无回复情况对回复进行调整:共有 203 位受访者(35%),其中 159 位(78%)为 BPCI-A 参与者,44 位(22%)为非参与者。平均而言,受访者报告实施了 89% 的住院领域策略,如护理路径或预测分析;65% 的急性期后策略,如与专业护理机构建立合作关系;84% 的门诊策略,如安排密切随访以防止急诊就诊/住院;以及 82% 的针对高风险人群的策略,如与社区资源建立联系。在所调查的 20 项护理重新设计策略中,有 19 项在 BPCI-A 医院和非 BPCI-A 医院之间没有差异。但是,78.3% 的 BPCI-A 参与医院报告了旨在减少专业护理和住院康复设施使用的计划,而非 BPCI-A 医院的这一比例为 37.6%(P 结论:BPCI-A 参与医院和非 BPCI-A 医院在减少专业护理和住院康复设施使用方面开展了广泛的工作:医院为提高质量做出了广泛的努力。BPCI-A 医院已尝试减少急性期后护理的使用,但除此之外,他们所采取的策略与其他医院类似。
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引用次数: 0
Adherence patterns 1 year after initiation of SGLT2 inhibitors: results of a national cohort study. 开始使用 SGLT2 抑制剂 1 年后的依从性模式:一项全国队列研究的结果。
IF 2.5 4区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-08-01 DOI: 10.37765/ajmc.2024.89591
Hsiao-Ching Huang, Daniel R Touchette, Mina Tadrous, Glen T Schumock, Saria Awadalla, Todd A Lee

Objectives: Adherence to medications is important for the management of chronic diseases. Although the proportion of days covered (PDC) is a common metric for measuring adherence, it may be insufficient to distinguish relevant differences in medication-taking behavior. Group-based trajectory models (GBTMs) have been used to better represent adherence over time. This study aims to examine adherence patterns 1 year after initiation among users of sodium-glucose cotransporter 2 (SGLT2) inhibitors using GBTMs and evaluate the ability of baseline characteristics to predict adherence trajectory.

Study design: SGLT2 inhibitor new-user cohort study from 2014 to 2018.

Methods: We calculated 12-month PDC and categorized patients with PDC of 80% or greater as adherent. We performed multivariable logistic regression on adherence status controlling for baseline covariates. GBTMs were fit to identify adherence patterns 12 months following SGLT2 inhibitor initiation. Five multinomial logistic regression models including different subsets of predictors were used to predict adherence trajectory group assignment.

Results: In a cohort of 228,363 SGLT2 inhibitor users, the mean PDC was 57%, with 36% of the cohort being adherent. Overall, women and patients with anxiety or depression were less likely to be adherent. Six patterns of SGLT2 inhibitor adherence were identified with GBTMs: 1 fill (PDC = 0.08), early discontinuation (PDC = 0.22), consistently low adherence (PDC = 0.35), moderate adherence (PDC = 0.48), high adherence (PDC = 0.79), and near-perfect adherence (PDC = 0.95). All prediction models showed poor predictive accuracy (0.35).

Conclusions: We found wide variation in adherence patterns among SGLT2 inhibitor users in a national cohort. Predictors from a health care claims database were unable to accurately predict adherence trajectory.

目的:坚持服药对于慢性病的治疗非常重要。虽然覆盖天数比例(PDC)是衡量服药依从性的常用指标,但它可能不足以区分服药行为的相关差异。基于群体的轨迹模型(GBTM)被用来更好地反映随时间变化的依从性。本研究旨在使用 GBTM 检验钠-葡萄糖共转运体 2(SGLT2)抑制剂使用者在开始用药 1 年后的依从性模式,并评估基线特征预测依从性轨迹的能力:2014年至2018年SGLT2抑制剂新用户队列研究:我们计算了 12 个月的 PDC,并将 PDC 达到或超过 80% 的患者归类为依从性患者。我们对依从性状态进行了多变量逻辑回归,并控制了基线协变量。对 GBTM 进行拟合,以确定 SGLT2 抑制剂启用 12 个月后的依从性模式。五个多项式逻辑回归模型包括不同的预测因子子集,用于预测依从性轨迹组的分配:在 228363 名 SGLT2 抑制剂使用者的队列中,平均 PDC 为 57%,其中 36% 的人坚持用药。总体而言,女性和焦虑或抑郁症患者的依从性较低。通过 GBTM 确定了六种 SGLT2 抑制剂依从性模式:1 次填充(PDC = 0.08)、早期停药(PDC = 0.22)、持续低依从性(PDC = 0.35)、中度依从性(PDC = 0.48)、高度依从性(PDC = 0.79)和接近完美依从性(PDC = 0.95)。所有预测模型的预测准确率均较低(0.35):我们发现,在全国队列中,SGLT2 抑制剂使用者的依从性模式差异很大。来自医疗索赔数据库的预测因子无法准确预测依从性轨迹。
{"title":"Adherence patterns 1 year after initiation of SGLT2 inhibitors: results of a national cohort study.","authors":"Hsiao-Ching Huang, Daniel R Touchette, Mina Tadrous, Glen T Schumock, Saria Awadalla, Todd A Lee","doi":"10.37765/ajmc.2024.89591","DOIUrl":"10.37765/ajmc.2024.89591","url":null,"abstract":"<p><strong>Objectives: </strong>Adherence to medications is important for the management of chronic diseases. Although the proportion of days covered (PDC) is a common metric for measuring adherence, it may be insufficient to distinguish relevant differences in medication-taking behavior. Group-based trajectory models (GBTMs) have been used to better represent adherence over time. This study aims to examine adherence patterns 1 year after initiation among users of sodium-glucose cotransporter 2 (SGLT2) inhibitors using GBTMs and evaluate the ability of baseline characteristics to predict adherence trajectory.</p><p><strong>Study design: </strong>SGLT2 inhibitor new-user cohort study from 2014 to 2018.</p><p><strong>Methods: </strong>We calculated 12-month PDC and categorized patients with PDC of 80% or greater as adherent. We performed multivariable logistic regression on adherence status controlling for baseline covariates. GBTMs were fit to identify adherence patterns 12 months following SGLT2 inhibitor initiation. Five multinomial logistic regression models including different subsets of predictors were used to predict adherence trajectory group assignment.</p><p><strong>Results: </strong>In a cohort of 228,363 SGLT2 inhibitor users, the mean PDC was 57%, with 36% of the cohort being adherent. Overall, women and patients with anxiety or depression were less likely to be adherent. Six patterns of SGLT2 inhibitor adherence were identified with GBTMs: 1 fill (PDC = 0.08), early discontinuation (PDC = 0.22), consistently low adherence (PDC = 0.35), moderate adherence (PDC = 0.48), high adherence (PDC = 0.79), and near-perfect adherence (PDC = 0.95). All prediction models showed poor predictive accuracy (0.35).</p><p><strong>Conclusions: </strong>We found wide variation in adherence patterns among SGLT2 inhibitor users in a national cohort. Predictors from a health care claims database were unable to accurately predict adherence trajectory.</p>","PeriodicalId":50808,"journal":{"name":"American Journal of Managed Care","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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American Journal of Managed Care
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