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A dopamine D1-like receptor-specific agonist improves the survival of septic mice 多巴胺 D1 样受体特异性激动剂能提高脓毒症小鼠的存活率
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109587
Koichi Tanaka, Mohammed E. Choudhury, Satoshi Kikuchi, Ikuko Takeda, K. Umakoshi, N. Miyaue, Kanta Mikami, Ayane Takenaga, Harumichi Yagi, Rintaro Shinabe, Hironori Matsumoto, Hajime Yano, Masahiro Nagai, J. Takeba, Junya Tanaka
{"title":"A dopamine D1-like receptor-specific agonist improves the survival of septic mice","authors":"Koichi Tanaka, Mohammed E. Choudhury, Satoshi Kikuchi, Ikuko Takeda, K. Umakoshi, N. Miyaue, Kanta Mikami, Ayane Takenaga, Harumichi Yagi, Rintaro Shinabe, Hironori Matsumoto, Hajime Yano, Masahiro Nagai, J. Takeba, Junya Tanaka","doi":"10.1016/j.isci.2024.109587","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109587","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"12 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140401114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial resistance to temperate phage is influenced by the frequency of lysogenic establishment 细菌对温带噬菌体的抗性受溶菌体建立频率的影响
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109595
Hiba Baaziz, Rita Makhlouf, Michael McClelland, Bryan B. Hsu
{"title":"Bacterial resistance to temperate phage is influenced by the frequency of lysogenic establishment","authors":"Hiba Baaziz, Rita Makhlouf, Michael McClelland, Bryan B. Hsu","doi":"10.1016/j.isci.2024.109595","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109595","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"134 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1 药理抑制 RAS 可通过 AP-1 和 RUNX1 克服 FLT3-ITD+ AML 对 FLT3 抑制剂的耐药性
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109576
D. Coleman, P. Keane, P. Chin, L. Ames, S. Kellaway, Helen J. Blair, Naeem Khan, James Griffin, Elisabeth Holmes, A. Maytum, S. Potluri, Lara Strate, Kinga Koscielniak, Manoj Raghavan, John H Bushweller, Olaf Heidenreich, Terry Rabbitts, P. Cockerill, C. Bonifer
{"title":"Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1","authors":"D. Coleman, P. Keane, P. Chin, L. Ames, S. Kellaway, Helen J. Blair, Naeem Khan, James Griffin, Elisabeth Holmes, A. Maytum, S. Potluri, Lara Strate, Kinga Koscielniak, Manoj Raghavan, John H Bushweller, Olaf Heidenreich, Terry Rabbitts, P. Cockerill, C. Bonifer","doi":"10.1016/j.isci.2024.109576","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109576","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"12 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting SRSF2 Mutations in Leukemia with RKI-1447: A Strategy to Impair Cellular Division and Nuclear Structure 用 RKI-1447 攻克白血病中的 SRSF2 基因突变：损害细胞分裂和核结构的策略
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109443
Minhua Su, Tom Fleisher, Inna Grosheva, Melanie B Horev, Malgorzata Olszewska, Camilla Ciolli Mattioli, H. Barr, Alexander Plotnikov, Silvia Carvalho, Yoni Moskovich, Mark D. Minden, N. Chapal-Ilani, Alexander Wainstein, E. Papapetrou, N. Dezorella, Tao Cheng, N. Kaushansky, Benjamin Geiger, L. Shlush
{"title":"Targeting SRSF2 Mutations in Leukemia with RKI-1447: A Strategy to Impair Cellular Division and Nuclear Structure","authors":"Minhua Su, Tom Fleisher, Inna Grosheva, Melanie B Horev, Malgorzata Olszewska, Camilla Ciolli Mattioli, H. Barr, Alexander Plotnikov, Silvia Carvalho, Yoni Moskovich, Mark D. Minden, N. Chapal-Ilani, Alexander Wainstein, E. Papapetrou, N. Dezorella, Tao Cheng, N. Kaushansky, Benjamin Geiger, L. Shlush","doi":"10.1016/j.isci.2024.109443","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109443","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"16 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140083795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green synthesis of reduced graphene oxide by using tropical microalgae and its application in biophotovoltaic devices 利用热带微藻绿色合成还原氧化石墨烯及其在生物光电器件中的应用
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109564
Jing-Ye Tee, Fong-Lee Ng, Fiona Seh-Lin Keng, Choon-Weng Lee, Bingqing Zhang, Shiwei Lin, G. Gnana kumar, Siew-Moi Phang
{"title":"Green synthesis of reduced graphene oxide by using tropical microalgae and its application in biophotovoltaic devices","authors":"Jing-Ye Tee, Fong-Lee Ng, Fiona Seh-Lin Keng, Choon-Weng Lee, Bingqing Zhang, Shiwei Lin, G. Gnana kumar, Siew-Moi Phang","doi":"10.1016/j.isci.2024.109564","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109564","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"317 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
circKDM1A suppresses bladder cancer progression by sponging miR-889-3p/CPEB3 and stabilizing p53 mRNA circKDM1A 通过疏导 miR-889-3p/CPEB3 和稳定 p53 mRNA 来抑制膀胱癌的进展
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109624
Haotian Chen, Jing Wen, Wentao Zhang, Wenchao Ma, Yadong Guo, Liliang Shen, Zhijin Zhang, Fu-han Yang, Yue Zhang, Yaohui Gao, Tianyuan Xu, Yang Yan, Wei Li, Junfeng Zhang, Shiyu Mao, Xudong Yao
{"title":"circKDM1A suppresses bladder cancer progression by sponging miR-889-3p/CPEB3 and stabilizing p53 mRNA","authors":"Haotian Chen, Jing Wen, Wentao Zhang, Wenchao Ma, Yadong Guo, Liliang Shen, Zhijin Zhang, Fu-han Yang, Yue Zhang, Yaohui Gao, Tianyuan Xu, Yang Yan, Wei Li, Junfeng Zhang, Shiyu Mao, Xudong Yao","doi":"10.1016/j.isci.2024.109624","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109624","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"38 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum 将基于 CRISPR/dCas9 的基因调控技术转化为恶性疟原虫的前向筛选工具
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109602
A. Lucky, Chengqi Wang, Xiaolian Li, Xiaoying Liang, Azhar Muneer, Jun Miao
{"title":"Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum","authors":"A. Lucky, Chengqi Wang, Xiaolian Li, Xiaoying Liang, Azhar Muneer, Jun Miao","doi":"10.1016/j.isci.2024.109602","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109602","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"35 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell transcriptional landscapes of bovine peri-implantation development 牛植入前发育的单细胞转录图谱
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109605
G. Scatolin, H. Ming, Yinjuan Wang, R. Iyyappan, Emilio Gutierrez Castillo, Linkai Zhu, Masroor Sagheer, Chao Song, K. Bondioli, Zongliang Jiang
{"title":"Single-cell transcriptional landscapes of bovine peri-implantation development","authors":"G. Scatolin, H. Ming, Yinjuan Wang, R. Iyyappan, Emilio Gutierrez Castillo, Linkai Zhu, Masroor Sagheer, Chao Song, K. Bondioli, Zongliang Jiang","doi":"10.1016/j.isci.2024.109605","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109605","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-β signaling 有机磷酸盐而非无机磷酸盐通过 MAPK 和 TGF-β 信号调节 Fgf23 的表达
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109625
Danielle Ratsma, Max Muller, M. Koedam, J.P.T.M. van Leeuwen, M. Zillikens, Bram C.J. van der Eerden
{"title":"Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-β signaling","authors":"Danielle Ratsma, Max Muller, M. Koedam, J.P.T.M. van Leeuwen, M. Zillikens, Bram C.J. van der Eerden","doi":"10.1016/j.isci.2024.109625","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109625","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"20 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single cell characterization of blood and expanded regulatory T cells in autoimmune polyendocrine syndrome type 1 自身免疫性多内分泌综合征 1 型血液和扩增的调节性 T 细胞的单细胞表征
iScience
Pub Date : 2024-03-01 DOI: 10.1016/j.isci.2024.109610
T. Sjøgren, Shahinul Islam, Igor Filippov, Adrianna Jebrzycka, André Sulen, L. Breivik, Alexander Hellesen, Anders P. Jørgensen, Kari Lima, L. Tserel, K. Kisand, Pärt Peterson, A. Ranki, E. Husebye, B. Oftedal, A. S. Wolff
{"title":"Single cell characterization of blood and expanded regulatory T cells in autoimmune polyendocrine syndrome type 1","authors":"T. Sjøgren, Shahinul Islam, Igor Filippov, Adrianna Jebrzycka, André Sulen, L. Breivik, Alexander Hellesen, Anders P. Jørgensen, Kari Lima, L. Tserel, K. Kisand, Pärt Peterson, A. Ranki, E. Husebye, B. Oftedal, A. S. Wolff","doi":"10.1016/j.isci.2024.109610","DOIUrl":"https://doi.org/10.1016/j.isci.2024.109610","url":null,"abstract":"","PeriodicalId":508122,"journal":{"name":"iScience","volume":"154 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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