Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2497979
R Jean Cadigan, Margaret Waltz
{"title":"Scientists' and Policy Professionals' Views on the Translational Pipeline of Human Gene Editing.","authors":"R Jean Cadigan, Margaret Waltz","doi":"10.1080/15265161.2025.2497979","DOIUrl":"10.1080/15265161.2025.2497979","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"28-30"},"PeriodicalIF":20.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2498847
Willow Shanks, Tod Chambers
{"title":"DIY Justice.","authors":"Willow Shanks, Tod Chambers","doi":"10.1080/15265161.2025.2498847","DOIUrl":"https://doi.org/10.1080/15265161.2025.2498847","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"93-94"},"PeriodicalIF":17.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2497985
Geoffrey R Engel, J Wesley Boyd
{"title":"Translational Justice: A Worthy Goal Whose Argument Needs to be Pushed Even Further.","authors":"Geoffrey R Engel, J Wesley Boyd","doi":"10.1080/15265161.2025.2497985","DOIUrl":"https://doi.org/10.1080/15265161.2025.2497985","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"26-28"},"PeriodicalIF":17.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-02-23DOI: 10.1080/15265161.2025.2457713
Megan A Allyse, Preya Agam, Yvonne Bombard, Roel Feys, McKenna Horstmann, Assata Kokayi, Rosario Isasi, Karen M Meagher, Marsha Michie, Kiran Musunuru, Kelly E Ormond, Kirsten A Riggan, Jane Q Yap
Despite considerable scientific progress and the evolution of regulatory pathways to ensure safety and efficacy, US healthcare continues to see increasing health disparities. This suggests that clinical translation in of itself cannot be the only measure of its own success, especially when the most marginalized patients, are neglected in the development and implementation of medical innovations. This raises the question of whether a system that is narrowly focused on technical achievement can meet the moral obligations of medicine and public health. We argue that traditional technocratic standards are failing to integrate normative considerations into biomedical translation. What is needed is a translational domain that moves beyond safety and efficacy toward anticipating how proposed technologies will be effective in society as it exists. We propose an additional metric of success: translational justice.
{"title":"Building Better Medicine: Translational Justice and the Quest for Equity in US Healthcare.","authors":"Megan A Allyse, Preya Agam, Yvonne Bombard, Roel Feys, McKenna Horstmann, Assata Kokayi, Rosario Isasi, Karen M Meagher, Marsha Michie, Kiran Musunuru, Kelly E Ormond, Kirsten A Riggan, Jane Q Yap","doi":"10.1080/15265161.2025.2457713","DOIUrl":"10.1080/15265161.2025.2457713","url":null,"abstract":"<p><p>Despite considerable scientific progress and the evolution of regulatory pathways to ensure safety and efficacy, US healthcare continues to see increasing health disparities. This suggests that clinical translation in of itself cannot be the only measure of its own success, especially when the most marginalized patients, are neglected in the development and implementation of medical innovations. This raises the question of whether a system that is narrowly focused on technical achievement can meet the moral obligations of medicine and public health. We argue that traditional technocratic standards are failing to integrate normative considerations into biomedical translation. What is needed is a translational domain that moves beyond safety and efficacy toward anticipating how proposed technologies will be effective in society as it exists. We propose an additional metric of success: translational justice.</p>","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":" ","pages":"11-25"},"PeriodicalIF":17.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2497983
Jeffrey Kirby
Currently, the provision of gender-affirming care to transgender and gender-diverse youth is highly contested. Fractious debate is being waged by GAC-permissive and GAC-restrictive proponents which has, importantly, spilled-over into the political domain. In the paper, an ethics analysis of gender-affirming care for youth is employed through the application of a set of relevant, ethics lenses, i.e., individual and relational autonomy; patient welfare (comparative benefits and burdens of GAC); health equity; traditional-distributive, formal and social justice; and injustices related to health research and political interference. In the author's view, this multi-lens analysis supports the continued use of a potentially adapted version of the gender-affirming care model in the assessment and treatment of transgender and gender-diverse youth. Arising from the analysis, a set of suggested recommendations is proposed that could potentially inform clinical practice and the development/revision of gender-affirming care for youth practice-standards, health policy and legislation.
{"title":"A Multi-Lens Ethics Analysis of Gender-Affirming Care for Youth with Implications for Practice and Policy.","authors":"Jeffrey Kirby","doi":"10.1080/15265161.2025.2497983","DOIUrl":"https://doi.org/10.1080/15265161.2025.2497983","url":null,"abstract":"<p><p>Currently, the provision of gender-affirming care to transgender and gender-diverse youth is highly contested. Fractious debate is being waged by GAC-permissive and GAC-restrictive proponents which has, importantly, spilled-over into the political domain. In the paper, an ethics analysis of gender-affirming care for youth is employed through the application of a set of relevant, ethics lenses, i.e., individual and relational autonomy; patient welfare (comparative benefits and burdens of GAC); health equity; traditional-distributive, formal and social justice; and injustices related to health research and political interference. In the author's view, this multi-lens analysis supports the continued use of a potentially adapted version of the gender-affirming care model in the assessment and treatment of transgender and gender-diverse youth. Arising from the analysis, a set of suggested recommendations is proposed that could potentially inform clinical practice and the development/revision of gender-affirming care for youth practice-standards, health policy and legislation.</p>","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"57-72"},"PeriodicalIF":17.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2497990
Moti Gorin, Chan Kulatunga-Moruzi, Ari R Joffe, J Cohn
{"title":"Ethical Care Necessitates Synthesizing the Best Available Evidence.","authors":"Moti Gorin, Chan Kulatunga-Moruzi, Ari R Joffe, J Cohn","doi":"10.1080/15265161.2025.2497990","DOIUrl":"https://doi.org/10.1080/15265161.2025.2497990","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"73-76"},"PeriodicalIF":17.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2497992
Myles N LaValley, Danielle J Eble, Rebecca Arteaga, Russell E Ettinger, Shane D Morrison
{"title":"Conscientious Objection to Gender-Affirming Surgery: Considerations for Training Programs.","authors":"Myles N LaValley, Danielle J Eble, Rebecca Arteaga, Russell E Ettinger, Shane D Morrison","doi":"10.1080/15265161.2025.2497992","DOIUrl":"https://doi.org/10.1080/15265161.2025.2497992","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"87-89"},"PeriodicalIF":17.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2497987
John Noel Montaño Viaña, Merryn McKinnon, Carys Fisser
{"title":"Integrating Bioethics and Science Communication Insights to Promote Translational Justice, Critical Consciousness, and Global Health Equity in COVID-19 Vaccination.","authors":"John Noel Montaño Viaña, Merryn McKinnon, Carys Fisser","doi":"10.1080/15265161.2025.2497987","DOIUrl":"10.1080/15265161.2025.2497987","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"120-124"},"PeriodicalIF":20.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2497994
Jelani Kerr, Lesley Harris, Nqobile Nzama
{"title":"Remember the White Supremacy: Responding to ARIE: A Health Equity Framework for Public Health Interventions Informed by Critical Race Theory and Critical Gerontology.","authors":"Jelani Kerr, Lesley Harris, Nqobile Nzama","doi":"10.1080/15265161.2025.2497994","DOIUrl":"10.1080/15265161.2025.2497994","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"115-117"},"PeriodicalIF":20.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-06-06DOI: 10.1080/15265161.2025.2498008
Armand H Matheny Antommaria
{"title":"Adding Ontological and Epistemological Lenses and Polishing Ethical Ones in the Analysis of Gender-Affirming Care.","authors":"Armand H Matheny Antommaria","doi":"10.1080/15265161.2025.2498008","DOIUrl":"https://doi.org/10.1080/15265161.2025.2498008","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 6","pages":"78-81"},"PeriodicalIF":17.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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