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This paper publishes the sixty-nine surviving very personal letters that Reichsgraf von Rumford wrote to Viscountess Palmerston after they met in Milan in 1793. The letters draw attention to the private domestic spaces of science and the critical importance of the aristocracy in scientific developments, topics that have both received some discussion recently. They were, however, not written with the purpose of providing historical evidence, but as part of a decade-long friendship which the letters trace, revealing, among other things, Rumford's other amours. They also describe in some detail his thoughts about his activities as a member of the governing elite in Bavaria, his scientific and engineering researches (especially the writing and publication of his Essays), as well as what he would have termed his philanthropic efforts in Bavaria, Northern Italy, Britain, and Ireland. All this is framed within the context of the Revolutionary and Napoleonic wars that in so many ways, directly and indirectly, affected Palmerston's and Rumford's lives and work.

Background: Asymptomatic/presymptomatic COVID-19 affected individuals who may appear healthy during blood donor screening can donate blood despite being infective. Most blood donors in India are relatives/friends/acquaintances of patients, who under peer pressure overlook the donor selection process, which can significantly impact the transfusion safety.

Aims: The prevalence of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) antibodies among blood donors was assessed, along with the possible transmissibility of SARS-CoV-2 virus in transfusion recipients of blood components prepared from sero-reactive blood donors.

Settings and design: A prospective cross-sectional study was conducted among eligible blood donors from November-2020 to April 2021.

Methods: 1500 blood donors were tested for SARS-CoV-2 IgG antibodies. Sero-reactive donors were followed-up telephonically to inquire about risk factors prior to donation or appearance of COVID-19 related symptoms postdonation. Patients transfused with blood components from seroreactive donors were also followed up for posttransfusion symptoms suggestive for COVID-19. Descriptive analysis was done for the donor and patient follow-up data.

Results: A total of 452 (30.1%) donor were reactive, with median S/CO ratio of 2.8 (interquartile range 1.5-5.5). Risk factors such as travel, contact, or quarantine were significantly higher among reactive donors. History of diabetes and/or hypertension was associated with seroreactivity. Total 516 patients were transfused with blood components from these seroreactive donors. Three patients developed fever after transfusion, one of which was found to be PCR positive after 4 days of transfusion.

Conclusion: Sero-reactivity rate among blood donors was lower than the general population. Optimum blood donor screening strategies can help decrease the possibility of blood collection from infected blood donors.

This article presents the decryption, historical analysis, and alchemical interpretation of an alchemical cipher found in a shared notebook of John and Arthur Dee (British Library MS Sloane 1902). The cipher is an early example of a Bellaso/Della Porta/Vigenère type, a strong encryption method which was historically deemed indecipherable. The essay explores the medical and alchemical context for the manuscript into which the cipher was copied and provides the transcription, plaintext solution (in Latin), and English translation of the encrypted text. Further, it interprets the enciphered text through the lens of alchemical practice and provides evidence for the dissemination of this cipher as part of a larger alchemical knowledge network.

The categories of "amateur" and "professional" remain central in studies on the sociology of nineteenth-century science. This article joins a growing body of literature that points out the complicated and intersecting connections between these two groups and how blurred the boundaries could be. This study focuses on pyrotechny, the art of fireworks, a field of far more obvious importance in the nineteenth century than it is today. Firework displays were mounted by artisan firework makers, who by the end of the century had become industrialists, and by military specialists, usually artillerymen. They had also become a common amateur pursuit. Across the nineteenth century, the art was transformed by the introduction of new materials, and the key discoveries were the work of enthusiasts who did not seek to profit financially from their discoveries. In this sense, they too were amateurs, although some had a scientific education. This article asks how they were able to make such major contributions to the field, and it situates them within networks that often crossed the boundaries between those who made fireworks for a living, or who studied them in military contexts, and those who were simple enthusiasts.