Pub Date : 2026-03-22DOI: 10.1021/acs.langmuir.6c00444
Yijie Miao,Xiaoqing Sun,Guo Lu,Xiusong Hou
The impact behavior of droplets on heterogeneous hydrophilic–hydrophobic surfaces has significant research value for applications such as surface coating and inkjet printing. However, due to the nonuniform distribution of surface wettability, the mechanisms governing dynamic spreading during droplet impact remain unclear. Through systematic experiments, this study investigates the dynamic spreading behavior of droplets on flexible, heterogeneous surfaces with varying hydrophilic–hydrophobic properties under different Weber numbers, revealing how substrate flexibility modulates energy dissipation and contact line dynamics, thereby influencing the maximum spreading diameter. Building upon classical droplet spreading theory for rigid walls, a predictive model for the maximum spreading diameter of droplets on flexible, hydrophilic–hydrophobic heterogeneous surfaces is established. The model is optimized and validated using experimental data. This research provides theoretical support for the controlled deposition of droplets on heterogeneous, flexible surfaces. It offers an important reference for studying fluid-dynamic behavior on complex wettable surfaces.
{"title":"Spreading Dynamics and Predictive Modeling for Liquid Droplets Impacting Elastic Heterogeneous Surfaces","authors":"Yijie Miao,Xiaoqing Sun,Guo Lu,Xiusong Hou","doi":"10.1021/acs.langmuir.6c00444","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c00444","url":null,"abstract":"The impact behavior of droplets on heterogeneous hydrophilic–hydrophobic surfaces has significant research value for applications such as surface coating and inkjet printing. However, due to the nonuniform distribution of surface wettability, the mechanisms governing dynamic spreading during droplet impact remain unclear. Through systematic experiments, this study investigates the dynamic spreading behavior of droplets on flexible, heterogeneous surfaces with varying hydrophilic–hydrophobic properties under different Weber numbers, revealing how substrate flexibility modulates energy dissipation and contact line dynamics, thereby influencing the maximum spreading diameter. Building upon classical droplet spreading theory for rigid walls, a predictive model for the maximum spreading diameter of droplets on flexible, hydrophilic–hydrophobic heterogeneous surfaces is established. The model is optimized and validated using experimental data. This research provides theoretical support for the controlled deposition of droplets on heterogeneous, flexible surfaces. It offers an important reference for studying fluid-dynamic behavior on complex wettable surfaces.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"15 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-22DOI: 10.1021/acs.langmuir.5c04625
Junteng Wang,Mengqing Li,Xue Yang,Zeyun Li,Di Tan,Xin Wang,Shenlin Yang
The surface/interface properties of materials affect their tribological behavior significantly, necessitating quantitative research. Here, a hybrid machine learning model named CS-LSBoost (Cuckoo Searching-Least Square Boosting) is proposed to evaluate and predict the tribological properties, considering surface/interface properties as input. The incorporation of the CS algorithm in the proposed model accelerates the modeling procedure and improves accuracy. In contrast to the conventional LSBoost algorithm, the CS-LSBoost algorithm exhibits superior performance that reduces the MAPE (mean average percentage error) on the CV (Cross-Validation) set in the friction task from 15.41% to 12.10% and in the wear task from 14.97% to 10.09%. When predicting the coef. friction and wear rate, the validation MAPEs on the hold-out set were only 6.31% and 9.54%, respectively. The proposed prediction model, with accurate quantitative correlation and appropriate physical interpretability between the tribological performance and the surface and interface properties of materials, can provide guidance for material optimization.
{"title":"A Machine Learning-Enabled Method for Predicting the Tribological Performance of Materials Considering Surface/Interface Properties.","authors":"Junteng Wang,Mengqing Li,Xue Yang,Zeyun Li,Di Tan,Xin Wang,Shenlin Yang","doi":"10.1021/acs.langmuir.5c04625","DOIUrl":"https://doi.org/10.1021/acs.langmuir.5c04625","url":null,"abstract":"The surface/interface properties of materials affect their tribological behavior significantly, necessitating quantitative research. Here, a hybrid machine learning model named CS-LSBoost (Cuckoo Searching-Least Square Boosting) is proposed to evaluate and predict the tribological properties, considering surface/interface properties as input. The incorporation of the CS algorithm in the proposed model accelerates the modeling procedure and improves accuracy. In contrast to the conventional LSBoost algorithm, the CS-LSBoost algorithm exhibits superior performance that reduces the MAPE (mean average percentage error) on the CV (Cross-Validation) set in the friction task from 15.41% to 12.10% and in the wear task from 14.97% to 10.09%. When predicting the coef. friction and wear rate, the validation MAPEs on the hold-out set were only 6.31% and 9.54%, respectively. The proposed prediction model, with accurate quantitative correlation and appropriate physical interpretability between the tribological performance and the surface and interface properties of materials, can provide guidance for material optimization.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"192 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1021/acs.langmuir.5c05899
Nikhil Mohandas,Hemraj Lakra,Riddhi Kamble,Susanta Banerjee,Arup R Bhattacharyya
This study reports the interfacial engineering of poly(vinylidene fluoride) (PVDF) nanocomposites using a hybrid nanofiller comprising few-layered graphene and a copper-based metal-organic framework (Cu-MOF) to simultaneously enhance piezoelectric energy harvesting and piezocatalytic activity. The nanocomposites were prepared via melt-mixing followed by solution-casting, enabling uniform hierarchical nanofiller dispersion and strong interfacial coupling with the PVDF matrix, as observed from detailed vibrational spectroscopy and microscopic analyses. FT-IR analysis revealed a remarkably high electroactive β/γ-phase content (∼97.2%) for 1.5 wt % hybrid nanofiller concentration, arising from synergistic dipole-dipole and ion-dipole interactions at the polymer-nanofiller interfaces. The corresponding piezoelectric nanogenerator delivered an open-circuit voltage of ∼58.3 V, a peak-to-peak voltage of ∼88.9 V, and a power density of ∼52.7 μW cm-2. Beyond energy harvesting, the PGM-1.5 nanocomposite film exhibited efficient dark piezocatalytic reduction of toxic Cr(VI) to Cr(III) (∼50% removal) under ultrasonic excitation, driven by mechanically induced polarization rather than cavitation or adsorption. Broadband dielectric spectroscopy, ferroelectric studies, and postcatalytic film stability analyses further confirmed lower dielectric losses for PVDF hybrid nanocomposites compared to neat PVDF, rapid interfacial charge dynamics, and structural robustness. These findings establish the Cu-MOF/graphene-engineered PVDF nanocomposite as a multifunctional platform for mechanically driven energy and environmental applications.
{"title":"Interfacial Coupling in Few-Layered Graphene and Metal Organic Framework-Incorporated Poly(vinylidene Fluoride) Nanocomposites Enabling Piezoelectric Energy Harvesting and Piezocatalytic Reduction of Hexavalent Chromium.","authors":"Nikhil Mohandas,Hemraj Lakra,Riddhi Kamble,Susanta Banerjee,Arup R Bhattacharyya","doi":"10.1021/acs.langmuir.5c05899","DOIUrl":"https://doi.org/10.1021/acs.langmuir.5c05899","url":null,"abstract":"This study reports the interfacial engineering of poly(vinylidene fluoride) (PVDF) nanocomposites using a hybrid nanofiller comprising few-layered graphene and a copper-based metal-organic framework (Cu-MOF) to simultaneously enhance piezoelectric energy harvesting and piezocatalytic activity. The nanocomposites were prepared via melt-mixing followed by solution-casting, enabling uniform hierarchical nanofiller dispersion and strong interfacial coupling with the PVDF matrix, as observed from detailed vibrational spectroscopy and microscopic analyses. FT-IR analysis revealed a remarkably high electroactive β/γ-phase content (∼97.2%) for 1.5 wt % hybrid nanofiller concentration, arising from synergistic dipole-dipole and ion-dipole interactions at the polymer-nanofiller interfaces. The corresponding piezoelectric nanogenerator delivered an open-circuit voltage of ∼58.3 V, a peak-to-peak voltage of ∼88.9 V, and a power density of ∼52.7 μW cm-2. Beyond energy harvesting, the PGM-1.5 nanocomposite film exhibited efficient dark piezocatalytic reduction of toxic Cr(VI) to Cr(III) (∼50% removal) under ultrasonic excitation, driven by mechanically induced polarization rather than cavitation or adsorption. Broadband dielectric spectroscopy, ferroelectric studies, and postcatalytic film stability analyses further confirmed lower dielectric losses for PVDF hybrid nanocomposites compared to neat PVDF, rapid interfacial charge dynamics, and structural robustness. These findings establish the Cu-MOF/graphene-engineered PVDF nanocomposite as a multifunctional platform for mechanically driven energy and environmental applications.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"28 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1021/acs.langmuir.5c06133
Iana Fomicheva,Petr Druzhinin,Mariia Pavlovska,Karen Ferner,Daniel Frese,George Sarau,Anca Mazare,Wolfgang H Goldmann,Ben Fabry,Silke H Christiansen,Alexander B Tesler
Cassie-Baxter superhydrophobic surfaces repel aqueous media by trapping a thin air layer known as plastron. However, current methods to estimate plastron characteristics on such surfaces, either directly through digital still imaging/confocal microscopy or indirectly through contact angle goniometry, are technically challenging and often imprecise. Previously, we demonstrated that the solid-liquid area fraction, which quantifies the fraction of the solid surface that is in direct contact with the surrounding liquid, can be accurately measured by reflectance optical microscopy, provided that the material surface has approximately uniform local reflectivity. To eliminate the complexity associated with optical reflectance measurements, we recently demonstrated that the drop adhesion force correlates linearly with the solid-liquid area fraction. In this study, we advance the drop adhesion force measurements obtained at different environments, compression distances, and during pressurization-hold experiments to reveal whether the plastron sustains external pressure or undergoes gradual collapse. Here, we demonstrate that measuring drop adhesion force is a robust, rapid, and technically simple method for assessing plastron properties under a wide range of environmental and surface conditions. The proposed method provides information on plastron stability within minutes and thus could aid in the design of ultrarepellent surfaces with long-term stability in demanding applications.
{"title":"Advanced Characterization of Plastron on Cassie-Baxter Superhydrophobic Surfaces by Drop Adhesion Force.","authors":"Iana Fomicheva,Petr Druzhinin,Mariia Pavlovska,Karen Ferner,Daniel Frese,George Sarau,Anca Mazare,Wolfgang H Goldmann,Ben Fabry,Silke H Christiansen,Alexander B Tesler","doi":"10.1021/acs.langmuir.5c06133","DOIUrl":"https://doi.org/10.1021/acs.langmuir.5c06133","url":null,"abstract":"Cassie-Baxter superhydrophobic surfaces repel aqueous media by trapping a thin air layer known as plastron. However, current methods to estimate plastron characteristics on such surfaces, either directly through digital still imaging/confocal microscopy or indirectly through contact angle goniometry, are technically challenging and often imprecise. Previously, we demonstrated that the solid-liquid area fraction, which quantifies the fraction of the solid surface that is in direct contact with the surrounding liquid, can be accurately measured by reflectance optical microscopy, provided that the material surface has approximately uniform local reflectivity. To eliminate the complexity associated with optical reflectance measurements, we recently demonstrated that the drop adhesion force correlates linearly with the solid-liquid area fraction. In this study, we advance the drop adhesion force measurements obtained at different environments, compression distances, and during pressurization-hold experiments to reveal whether the plastron sustains external pressure or undergoes gradual collapse. Here, we demonstrate that measuring drop adhesion force is a robust, rapid, and technically simple method for assessing plastron properties under a wide range of environmental and surface conditions. The proposed method provides information on plastron stability within minutes and thus could aid in the design of ultrarepellent surfaces with long-term stability in demanding applications.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"189 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Electrode materials are the key factors determining the performance of supercapacitors. An N-doped graphitized hierarchical porous carbon aerogel (NGHC) was prepared through freeze-drying and heat treatment of the zeolitic imidazolate framework-67 (ZIF-67)/sodium carboxymethyl cellulose (CMC)/potassium tris (oxalato) ferrate(III) trihydrate (K3[Fe(C2O4)3]) composite. In this process, ZIF-67 served as a precursor to generate N-doped porous carbon through thermal activation, and CMC acted as a binder linking carbon particles from ZIF-67 to form a continuous conductive framework. K3[Fe(C2O4)3] acted as both an activator and a catalyst, helping to develop porosity and graphitization. The resulting NGHC possessed a unique structure: a hierarchical pore structure, a high surface area, good conductivity, and a large number of N heteroatoms. Due to the synergistic effect of these factors, NGHC demonstrated a high specific capacitance of 261 F/g at 1 A/g in a three-electrode system. When employed in a supercapacitor, it delivered a superior energy density output of 18.75 Wh/kg at 1000 W/kg. These results reveal that NGHC is a potential electrode material in a supercapacitor.
电极材料是决定超级电容器性能的关键因素。将沸石型吡唑酸骨架-67 (ZIF-67)/羧甲基纤维素钠(CMC)/三（草酸）高铁酸钾（III）三水合物（K3[Fe(C2O4)3]）复合材料进行冷冻干燥和热处理，制备了n掺杂石墨化分层多孔碳气凝胶（NGHC）。在此过程中，ZIF-67作为前驱体通过热活化生成n掺杂多孔碳，CMC作为粘合剂将ZIF-67中的碳颗粒连接起来，形成连续的导电框架。K3[Fe(C2O4)3]作为活化剂和催化剂，有助于形成孔隙和石墨化。得到的NGHC具有独特的结构：分层孔结构、高比表面积、良好的导电性和大量的N杂原子。由于这些因素的协同作用，NGHC在三电极系统中表现出1 a /g时261 F/g的高比电容。当用于超级电容器时，它在1000 W/kg时提供了18.75 Wh/kg的优越能量密度输出。这些结果表明，NGHC是一种潜在的超级电容器电极材料。
{"title":"N-Doped Graphitized Hierarchical Porous Carbon Aerogel as an Electrode Material for Supercapacitors.","authors":"Yunjie Ping,Haochen Han,Zeyi Zhao,Xu Li,Shuang Meng","doi":"10.1021/acs.langmuir.6c00075","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c00075","url":null,"abstract":"Electrode materials are the key factors determining the performance of supercapacitors. An N-doped graphitized hierarchical porous carbon aerogel (NGHC) was prepared through freeze-drying and heat treatment of the zeolitic imidazolate framework-67 (ZIF-67)/sodium carboxymethyl cellulose (CMC)/potassium tris (oxalato) ferrate(III) trihydrate (K3[Fe(C2O4)3]) composite. In this process, ZIF-67 served as a precursor to generate N-doped porous carbon through thermal activation, and CMC acted as a binder linking carbon particles from ZIF-67 to form a continuous conductive framework. K3[Fe(C2O4)3] acted as both an activator and a catalyst, helping to develop porosity and graphitization. The resulting NGHC possessed a unique structure: a hierarchical pore structure, a high surface area, good conductivity, and a large number of N heteroatoms. Due to the synergistic effect of these factors, NGHC demonstrated a high specific capacitance of 261 F/g at 1 A/g in a three-electrode system. When employed in a supercapacitor, it delivered a superior energy density output of 18.75 Wh/kg at 1000 W/kg. These results reveal that NGHC is a potential electrode material in a supercapacitor.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1021/acs.langmuir.6c00352
Xingxing Liu,Jiafeng Hu,Xiaojun Chen,Longfei Yu,Kangle Jia,Yinlin Chu,Jiangbo Wang,Chengxiong Lin
The formation of pathogenic bacterial biofilms and thrombui is one of the most common causes of infections associated with medical implants. Proposing a new strategy to endow implant materials with effective antifouling and antibacterial properties, ensuring their safe and long-term use, is of great clinical significance. Therefore, an antibacterial and antifouling composite coating was proposed in this study. A zwitterionic copolymer, PSS containing MPC, NaSS, and DMA, was first prepared through free radical copolymerization. Dopamine and PSS copolymers were self-polymerized to form a composite coating, and the phenolic hydroxyl functional groups in the coating effectively chelated and reduced silver ions into silver nanoparticles. The results showed that the composite coatings all exhibited significant antifouling capabilities against proteins (BSA and BFG), platelets, and bacteria (S. aureus and E. coli). With the increased amount of MPC, specifically PVC/PSS262-Ag, the composite coating exhibited the most outstanding performance, with an antiprotein adsorption rate exceeding 90%. Cytotoxicity tests with HUVECs and rabbit blood demonstrated that the composite coating had an excellent biocompatibility. In summary, the dual antibacterial and antifouling coating proposed in this study holds great potential for application in controlling the formation of biofilms and thrombi on biomaterials.
{"title":"An Antibacterial and Antifouling MPC/NaSS/DMA Coating against Biofilms and Thrombi on Vascular Device Implants.","authors":"Xingxing Liu,Jiafeng Hu,Xiaojun Chen,Longfei Yu,Kangle Jia,Yinlin Chu,Jiangbo Wang,Chengxiong Lin","doi":"10.1021/acs.langmuir.6c00352","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c00352","url":null,"abstract":"The formation of pathogenic bacterial biofilms and thrombui is one of the most common causes of infections associated with medical implants. Proposing a new strategy to endow implant materials with effective antifouling and antibacterial properties, ensuring their safe and long-term use, is of great clinical significance. Therefore, an antibacterial and antifouling composite coating was proposed in this study. A zwitterionic copolymer, PSS containing MPC, NaSS, and DMA, was first prepared through free radical copolymerization. Dopamine and PSS copolymers were self-polymerized to form a composite coating, and the phenolic hydroxyl functional groups in the coating effectively chelated and reduced silver ions into silver nanoparticles. The results showed that the composite coatings all exhibited significant antifouling capabilities against proteins (BSA and BFG), platelets, and bacteria (S. aureus and E. coli). With the increased amount of MPC, specifically PVC/PSS262-Ag, the composite coating exhibited the most outstanding performance, with an antiprotein adsorption rate exceeding 90%. Cytotoxicity tests with HUVECs and rabbit blood demonstrated that the composite coating had an excellent biocompatibility. In summary, the dual antibacterial and antifouling coating proposed in this study holds great potential for application in controlling the formation of biofilms and thrombi on biomaterials.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"9 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1021/acs.langmuir.6c00518
Fereshteh Koohi,Hamid R Zare,Zahra Shekari
The early and precise detection of cancer biomarkers is essential for effective cancer therapy. This study introduces a photoelectrochemical (PEC) biosensor specifically designed for the quantification of microRNA-106b (miR-106b), a biomarker linked to gastric cancer. The PEC biosensor was developed through the synthesis of tin(IV) oxide (SnO2) nanoparticles on the surface of fluorine-doped tin oxide (FTO) via a spin-coating method. Subsequently, an amino-modified single-stranded DNA (ssDNA) was immobilized onto the SnO2/FTO electrode, which was further modified with gold nanoparticles (AuNPs). The fabrication processes of the PEC biosensor were assessed by using electrochemical impedance spectroscopy (EIS) and PEC measurements. Upon hybridization of the probe attached to the biosensor with miR-106b, a substantial reduction in photocurrent was observed due to the obstruction of the electrode surface, resulting in the formation of a steric barrier. This steric hindrance limits the diffusion of ascorbic acid (AA) to the electrode surface, consequently decreasing the level of trapping of photogenerated holes. The photocurrent responses of the proposed biosensor exhibited linearity within a concentration range of 1.0 fM to 0.1 μM miR-106b, with a detection limit of 0.12 fM. The biosensor demonstrated the capability to detect miR-106b in sequences with a single base mismatch and noncomplementary bases. Furthermore, the biosensor was successfully employed to quantify miR-106b in human serum samples, yielding satisfactory results. The innovation of this research resides in the development of a photoelectrochemical biosensor specifically targeting miRNA-106b. The incorporation of electrodeposited gold nanoparticles on SnO2 spin-coated FTO represents an approach to enhancing the performance and sensitivity of the sensor. This biosensor has potential applications across a range of areas in the field of miRNA detection.
{"title":"Development of a Photoelectrochemical Biosensor for the Detection of miRNA-106b Using Electrodeposited Gold Nanoparticles on SnO2 Spin-Coated FTO.","authors":"Fereshteh Koohi,Hamid R Zare,Zahra Shekari","doi":"10.1021/acs.langmuir.6c00518","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c00518","url":null,"abstract":"The early and precise detection of cancer biomarkers is essential for effective cancer therapy. This study introduces a photoelectrochemical (PEC) biosensor specifically designed for the quantification of microRNA-106b (miR-106b), a biomarker linked to gastric cancer. The PEC biosensor was developed through the synthesis of tin(IV) oxide (SnO2) nanoparticles on the surface of fluorine-doped tin oxide (FTO) via a spin-coating method. Subsequently, an amino-modified single-stranded DNA (ssDNA) was immobilized onto the SnO2/FTO electrode, which was further modified with gold nanoparticles (AuNPs). The fabrication processes of the PEC biosensor were assessed by using electrochemical impedance spectroscopy (EIS) and PEC measurements. Upon hybridization of the probe attached to the biosensor with miR-106b, a substantial reduction in photocurrent was observed due to the obstruction of the electrode surface, resulting in the formation of a steric barrier. This steric hindrance limits the diffusion of ascorbic acid (AA) to the electrode surface, consequently decreasing the level of trapping of photogenerated holes. The photocurrent responses of the proposed biosensor exhibited linearity within a concentration range of 1.0 fM to 0.1 μM miR-106b, with a detection limit of 0.12 fM. The biosensor demonstrated the capability to detect miR-106b in sequences with a single base mismatch and noncomplementary bases. Furthermore, the biosensor was successfully employed to quantify miR-106b in human serum samples, yielding satisfactory results. The innovation of this research resides in the development of a photoelectrochemical biosensor specifically targeting miRNA-106b. The incorporation of electrodeposited gold nanoparticles on SnO2 spin-coated FTO represents an approach to enhancing the performance and sensitivity of the sensor. This biosensor has potential applications across a range of areas in the field of miRNA detection.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimeric polyphenols have been postulated to be more effective in preventing obesity than monomeric ones; however, the mechanism through which polyphenols act on cells remains poorly understood. A leading hypothesis is the inactivation of the intracellular lipid synthesis signaling pathway that leads to lipid accumulation in 3T3-L1 preadipocytes through interference with the signaling activity of the raft domains of their plasma membranes. Thus, understanding the behavior of polyphenols on the membrane surface is essential to elucidating the mechanism through which they disrupt lipid raft structures differently. In this study, we first established two bilayer membrane models of different composition, the liquid-ordered (Lo) membrane containing cholesterol and sphingomyelin representing a raft domain, and the liquid-disordered (Ld) membrane containing phosphatidylcholine representing a nonraft domain; the surface behavior and consequent interaction of three representative polyphenols (one, a monomeric phenol and the other two, dimeric phenols) with the two bilayer membrane models were then investigated, computationally, through molecular dynamics simulations. The dimeric polyphenols were found to bind to both the Ld and Lo membranes through extensive hydrogen bonding, for the case of the Ld membrane penetrating deeper within the membrane than monophenol, but for the case of the Lo membrane locating predominantly to the lipid headgroups similar to monophenol. Moreover, the dimeric polyphenols exhibited significantly prolonged binding times in both Ld and Lo membranes with a more pronounced effect observed in the Lo membrane. Finally, Langmuir film balance measurements were performed to provide complementary evidence and support the results from the simulations.
{"title":"Dimeric Polyphenol Effect on Liquid-Ordered and Liquid-Disordered Membranes: Combined Insights from Molecular Dynamics Simulation and Langmuir Balance Measurements.","authors":"Ruifeng Wang,Suvi Heinonen,Elina Vuorimaa-Laukkanen,Chunmei Li,Tapani Viitala,Alex Bunker","doi":"10.1021/acs.langmuir.5c05280","DOIUrl":"https://doi.org/10.1021/acs.langmuir.5c05280","url":null,"abstract":"Dimeric polyphenols have been postulated to be more effective in preventing obesity than monomeric ones; however, the mechanism through which polyphenols act on cells remains poorly understood. A leading hypothesis is the inactivation of the intracellular lipid synthesis signaling pathway that leads to lipid accumulation in 3T3-L1 preadipocytes through interference with the signaling activity of the raft domains of their plasma membranes. Thus, understanding the behavior of polyphenols on the membrane surface is essential to elucidating the mechanism through which they disrupt lipid raft structures differently. In this study, we first established two bilayer membrane models of different composition, the liquid-ordered (Lo) membrane containing cholesterol and sphingomyelin representing a raft domain, and the liquid-disordered (Ld) membrane containing phosphatidylcholine representing a nonraft domain; the surface behavior and consequent interaction of three representative polyphenols (one, a monomeric phenol and the other two, dimeric phenols) with the two bilayer membrane models were then investigated, computationally, through molecular dynamics simulations. The dimeric polyphenols were found to bind to both the Ld and Lo membranes through extensive hydrogen bonding, for the case of the Ld membrane penetrating deeper within the membrane than monophenol, but for the case of the Lo membrane locating predominantly to the lipid headgroups similar to monophenol. Moreover, the dimeric polyphenols exhibited significantly prolonged binding times in both Ld and Lo membranes with a more pronounced effect observed in the Lo membrane. Finally, Langmuir film balance measurements were performed to provide complementary evidence and support the results from the simulations.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1021/acs.langmuir.5c05846
Laura X Sepulveda-Montaño,Chaila N Estrella,Amelia M Skinner,Daniel G Kuroda
Common separation techniques, such as liquid-liquid extraction, are usually used for extractions and purifications due to their industrial scalability and affordability. However, these well-established practices are hindered by low selectivity and challenges in recovering solutes and solvents. Deep eutectic solvents (DES), a fairly new type of solvent, have the potential to overcome these issues. DESs are binary mixtures whose physical properties can be tuned by selecting the appropriate precursors to facilitate and/or enhance processes such as extraction. A promising DES for selective separations is formed when lauric acid (LA) is mixed with N-methylacetamide (NMA). This LA-NMA DES has a heterogeneous microscopic structure that can solvate compounds with completely different polarities. This study explores how forming an organized structure on the mesoscale affects the solubility of nonpolar solutes in nonionic DESs. To this end, the molecular and mesoscale structures and their effect on the solubility and solvation properties are evaluated for the LA-NMA DES and two new DESs with slight chemical variations in their precursors. It is observed that the organization of the nonpolar DES domains and, consequently, of their interfaces directly relates to the solubility of nonpolar compounds. Specifically, correctly selecting the DES precursors that form organized nonpolar domains leads to an organized interface in which the nonpolar solutes are solvated, thereby increasing the solubility. Additionally, enhanced dissolution power was observed in a completely different DES with mesoscale order in its molecular structure and composed of menthol and lauric acid. The latter result further validates the proposed tunability of the DES dissolution power through organized interfaces, extending it beyond a specific DES family and opening the possibility of new extraction-tailored designer solvents.
{"title":"Tuning the Solvation and Solubility Properties of Molecularly Heterogeneous Nonionic Deep Eutectic Solvents via Interface Organization.","authors":"Laura X Sepulveda-Montaño,Chaila N Estrella,Amelia M Skinner,Daniel G Kuroda","doi":"10.1021/acs.langmuir.5c05846","DOIUrl":"https://doi.org/10.1021/acs.langmuir.5c05846","url":null,"abstract":"Common separation techniques, such as liquid-liquid extraction, are usually used for extractions and purifications due to their industrial scalability and affordability. However, these well-established practices are hindered by low selectivity and challenges in recovering solutes and solvents. Deep eutectic solvents (DES), a fairly new type of solvent, have the potential to overcome these issues. DESs are binary mixtures whose physical properties can be tuned by selecting the appropriate precursors to facilitate and/or enhance processes such as extraction. A promising DES for selective separations is formed when lauric acid (LA) is mixed with N-methylacetamide (NMA). This LA-NMA DES has a heterogeneous microscopic structure that can solvate compounds with completely different polarities. This study explores how forming an organized structure on the mesoscale affects the solubility of nonpolar solutes in nonionic DESs. To this end, the molecular and mesoscale structures and their effect on the solubility and solvation properties are evaluated for the LA-NMA DES and two new DESs with slight chemical variations in their precursors. It is observed that the organization of the nonpolar DES domains and, consequently, of their interfaces directly relates to the solubility of nonpolar compounds. Specifically, correctly selecting the DES precursors that form organized nonpolar domains leads to an organized interface in which the nonpolar solutes are solvated, thereby increasing the solubility. Additionally, enhanced dissolution power was observed in a completely different DES with mesoscale order in its molecular structure and composed of menthol and lauric acid. The latter result further validates the proposed tunability of the DES dissolution power through organized interfaces, extending it beyond a specific DES family and opening the possibility of new extraction-tailored designer solvents.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"6 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1021/acs.langmuir.5c06745
Suzilene V Santos,Crystian W C Silva,Pedro H Britto-Costa,Thiago Lopes,Sávio F Silva,Cleidilane S Costa,Larissa Otubo,C M Rivaldo-Gómez,Artur W Carbonari,Gabriel A Cabrera-Pasca
The design of hierarchical copper oxide microstructures with tailored nanomorphologies is essential for next-generation electrocatalytic, sensing, and nanoelectronic applications. Here, we report an atmosphere-controlled thermal oxidation route for the sustainable synthesis of hollow Cu/Cu2O/CuO microtubes decorated with a dense array of vertically aligned CuO nanowires. The synthesis uses recycled copper microwires from electronic waste (e-waste) coated with a polyurethane (PU) polymer. Comparative analysis under ambient air and high-purity synthetic air reveals that the thermal degradation of the polymeric coating forms a carbon-rich layer, crucial for regulating asymmetric cation transport and inducing mass transport that drives void formation via the Kirkendall effect. This mechanism transforms the solid microwire into a concentric hollow microtube structure. Critically, oxidation under synthetic air promotes the extensive growth of long CuO nanowires (up to 20 μm), guided by anisotropic diffusion along twin boundaries and sustained by a strong chemical potential gradient. These findings establish atmosphere control as a powerful strategy to fine-tune the multiscale architecture of sustainable metal oxide nanostructures from e-waste precursors, opening pathways for the scalable production of multifunctional materials.
{"title":"Atmosphere-Controlled Synthesis of Hierarchical Cu/Cu2O/CuO Microtube Architectures Decorated with High-Density CuO Nanowires from Recycled E-Waste.","authors":"Suzilene V Santos,Crystian W C Silva,Pedro H Britto-Costa,Thiago Lopes,Sávio F Silva,Cleidilane S Costa,Larissa Otubo,C M Rivaldo-Gómez,Artur W Carbonari,Gabriel A Cabrera-Pasca","doi":"10.1021/acs.langmuir.5c06745","DOIUrl":"https://doi.org/10.1021/acs.langmuir.5c06745","url":null,"abstract":"The design of hierarchical copper oxide microstructures with tailored nanomorphologies is essential for next-generation electrocatalytic, sensing, and nanoelectronic applications. Here, we report an atmosphere-controlled thermal oxidation route for the sustainable synthesis of hollow Cu/Cu2O/CuO microtubes decorated with a dense array of vertically aligned CuO nanowires. The synthesis uses recycled copper microwires from electronic waste (e-waste) coated with a polyurethane (PU) polymer. Comparative analysis under ambient air and high-purity synthetic air reveals that the thermal degradation of the polymeric coating forms a carbon-rich layer, crucial for regulating asymmetric cation transport and inducing mass transport that drives void formation via the Kirkendall effect. This mechanism transforms the solid microwire into a concentric hollow microtube structure. Critically, oxidation under synthetic air promotes the extensive growth of long CuO nanowires (up to 20 μm), guided by anisotropic diffusion along twin boundaries and sustained by a strong chemical potential gradient. These findings establish atmosphere control as a powerful strategy to fine-tune the multiscale architecture of sustainable metal oxide nanostructures from e-waste precursors, opening pathways for the scalable production of multifunctional materials.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"52 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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