Pub Date : 2024-06-05DOI: 10.36348/sjm.2024.v09i06.003
C. D, Keïta Kaly, Coulibaly, O, D. K, Sylla Mala, D. M, C. A, Sy Djibril, A, Koné A, A, Dollo, I, Kamissoko, C. O, M. A, D. M, G. H, D. Sow
Introduction: Diabetes is a major cause of death and disability worldwide. It also represents a significant risk factor for stroke. The excess stroke risk associated with diabetes is significantly higher in women than in men, independent of sex differences observed for other major cardiovascular risk factors. Materials and Method: This retrospective descriptive study was carried out in the Internal Medicine department of Point G University Hospital from January 2008 to December 2012. Included in this work were all type 2 diabetic patients hospitalized in the department during the duration of the study, presenting clinical signs of sentivo-motor deficit with performance of a brain CT scan. Results: At the end of this work, 358 patients were hospitalized, among whom 19 cases of established stroke were recorded, i.e. a frequency of 5.3%. Dilated cardiomyopathy represented 36.8% of cases. LVH and repolarization disorders accounted for 21.1% each. Composite ischemic stroke represented 79% of cases followed by mixed stroke or 16% of cases. The evolution was marked by after-effects such as left hemiparesis 36.8%, right hemiplegia 10.5% and death in 5.3% of cases. Dyslipidemia 82%, hypertension 84.21% were the risk factors most associated with diabetes. Conclusion: Strokes are common in type 2 diabetic patients. Their prevention requires better management of diabetes and its associated risk factors.
{"title":"Cerebral Vascular Accidents Occurring During Type 2 Diabetes in the CHU-PG Internal Medicine Department","authors":"C. D, Keïta Kaly, Coulibaly, O, D. K, Sylla Mala, D. M, C. A, Sy Djibril, A, Koné A, A, Dollo, I, Kamissoko, C. O, M. A, D. M, G. H, D. Sow","doi":"10.36348/sjm.2024.v09i06.003","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i06.003","url":null,"abstract":"Introduction: Diabetes is a major cause of death and disability worldwide. It also represents a significant risk factor for stroke. The excess stroke risk associated with diabetes is significantly higher in women than in men, independent of sex differences observed for other major cardiovascular risk factors. Materials and Method: This retrospective descriptive study was carried out in the Internal Medicine department of Point G University Hospital from January 2008 to December 2012. Included in this work were all type 2 diabetic patients hospitalized in the department during the duration of the study, presenting clinical signs of sentivo-motor deficit with performance of a brain CT scan. Results: At the end of this work, 358 patients were hospitalized, among whom 19 cases of established stroke were recorded, i.e. a frequency of 5.3%. Dilated cardiomyopathy represented 36.8% of cases. LVH and repolarization disorders accounted for 21.1% each. Composite ischemic stroke represented 79% of cases followed by mixed stroke or 16% of cases. The evolution was marked by after-effects such as left hemiparesis 36.8%, right hemiplegia 10.5% and death in 5.3% of cases. Dyslipidemia 82%, hypertension 84.21% were the risk factors most associated with diabetes. Conclusion: Strokes are common in type 2 diabetic patients. Their prevention requires better management of diabetes and its associated risk factors.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":"40 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141384340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-05DOI: 10.36348/sjm.2024.v09i06.002
C. D, D. M, Coulibaly, O, D. K, C. A, Sylla Mala, Keïta Kaly, S. Djibril, A. Koné, Drago, A. A, D. I, Kamissoko, C. O, M. A, D. M, G. H, D. Sow
Introduction: Sjögren's syndrome (SS) is a systemic autoimmune disease whose target is the epithelium of the exocrine glands and in particular the salivary glands. SS affects women more often with a sex ratio of 9 women to 1 man and the peak frequency is around age 50. It is mainly described in Western literature where it seems to come second after RA. In Africa, it is mainly reported in the Maghreb. We report a case, revealed by pulmonary damage at the Nianankoro Fomba hospital in Ségou. Observation: This was a patient, aged 50, without any particular ATCD, who had consulted for chronic cough with mucco-purulent sputum and dyspnea, which had been present for more than four (4) months. Faced with the failure of a trial anti-tuberculosis treatment despite the negativity of the sputum testing for BARR in the Pneumophthisiology department, she decided to consult internal medicine. Clinical examination revealed NYHA stage III dyspnea. A chest CT concluded with bilateral pulmonary parenchymal interstitial syndrome associated with inflammatory bronchopathy with bronchiectasis. The immunological assessment revealed positive anti–SSA and anti–SSB Abs. Clinical improvement was obtained after initiation of corticosteroids and immunosuppressants. Conclusion: This observation illustrates the interest of looking for latent SS in the etiological assessment of a persistent cough.
简介斯约格伦综合征（SS）是一种全身性自身免疫性疾病，其靶点是外分泌腺，尤其是唾液腺的上皮细胞。该病多发于女性，男女比例为 9:1，发病高峰在 50 岁左右。主要见于西方文献，似乎是仅次于 RA 的第二大疾病。在非洲，该病主要见于马格里布地区。我们报告了一例在塞古（Ségou）Nianankoro Fomba 医院发现的肺损伤病例。观察结果：患者 50 岁，无任何特殊的 ATCD，因慢性咳嗽伴粘液脓痰和呼吸困难就诊，病程已超过四（4）个月。尽管在肺病科进行的痰液 BARR 检测呈阴性，但抗结核治疗试验失败，因此她决定到内科就诊。临床检查显示，她患有 NYHA III 期呼吸困难。胸部 CT 的结论是双侧肺实质间质综合征伴有支气管扩张的炎症性支气管病。免疫学评估显示抗SSA和抗SSB抗体阳性。开始使用皮质类固醇和免疫抑制剂后，临床症状有所改善。结论：这一观察结果表明，在对顽固性咳嗽进行病因学评估时，寻找潜在的 SS 很有意义。
{"title":"A Case of Gougerot Sjögren Syndrome (SGS) Discovered by Chronic Pulmonary Impairment at the Nianankoro Fomba Hospital in Segou","authors":"C. D, D. M, Coulibaly, O, D. K, C. A, Sylla Mala, Keïta Kaly, S. Djibril, A. Koné, Drago, A. A, D. I, Kamissoko, C. O, M. A, D. M, G. H, D. Sow","doi":"10.36348/sjm.2024.v09i06.002","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i06.002","url":null,"abstract":"Introduction: Sjögren's syndrome (SS) is a systemic autoimmune disease whose target is the epithelium of the exocrine glands and in particular the salivary glands. SS affects women more often with a sex ratio of 9 women to 1 man and the peak frequency is around age 50. It is mainly described in Western literature where it seems to come second after RA. In Africa, it is mainly reported in the Maghreb. We report a case, revealed by pulmonary damage at the Nianankoro Fomba hospital in Ségou. Observation: This was a patient, aged 50, without any particular ATCD, who had consulted for chronic cough with mucco-purulent sputum and dyspnea, which had been present for more than four (4) months. Faced with the failure of a trial anti-tuberculosis treatment despite the negativity of the sputum testing for BARR in the Pneumophthisiology department, she decided to consult internal medicine. Clinical examination revealed NYHA stage III dyspnea. A chest CT concluded with bilateral pulmonary parenchymal interstitial syndrome associated with inflammatory bronchopathy with bronchiectasis. The immunological assessment revealed positive anti–SSA and anti–SSB Abs. Clinical improvement was obtained after initiation of corticosteroids and immunosuppressants. Conclusion: This observation illustrates the interest of looking for latent SS in the etiological assessment of a persistent cough.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":"2 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141383814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.36348/sjm.2024.v09i06.001
M. Errihani, A. Sobhi, K. Hassani, S. Benbria, D. Kabbaj
Introduction: in hemodialysis patients. Osteoporosis associated with kidney disease chronic is a complex entity with significant morbidity and mortality relative to risk of fracture. Its prevalence is high, but the incrimination of clinical and biological factors remains poorly identified. The purpose of our study is to determine the prevalence and factors associated with osteoporosis. Methods: A cross-sectional study included 40 chronic hemodialysis patients for at least 6 months. All subjects underwent a bone mineral density (BMD) assay with dual-energy x-rays absorptiometry (DXA) at the lumbar spine (LS) and femoral neck (FN). Data were statistically analyzed by means of descriptive analysis. Patients were divided into 2 groups based on the T-score to define the osteoporotic (t score≤-2.5) and the no-osteoporotic (t score>-2.5). The search for the risk factors studied [age, duration of hemodialysis, parathyroid hormone (PTH), alkaline phosphatases (ALP), and calcification of the abdominal aorta (AAC)] has been carried out by logistic regression. Results: The average age was 59 ± 16 years, 47% were women, and the median of hemodialysis duration was 54 months. The prevalence of osteoporosis at the lumbar spine was 27.5% and at the femoral neck was 32.5%. Regarding risk factors, at the LS, the factors associated with osteoporosis retained in the univariate analysis were age (p=0.034), PTH (p=0.024), AAC (p=0.024), ALP (p=0.027) and in the multivariate analysis, only PTH was significantly associated (p=0.019). At the FN; The factors associated with osteoporosis retained in analysis univariate were age (p = 0.03), AAC (p = 0.01), ALP (p=0.04) and in analysis multivariate was the APL (p= 0.035). Conclusion: Osteoporosis is associated with turnover abnormalities. We suggest that regular screening for fracture risk using DXA and early correction of the disorders.
{"title":"Risk Factors for Osteoporosis in Chronic Hemodialysis Patients","authors":"M. Errihani, A. Sobhi, K. Hassani, S. Benbria, D. Kabbaj","doi":"10.36348/sjm.2024.v09i06.001","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i06.001","url":null,"abstract":"Introduction: in hemodialysis patients. Osteoporosis associated with kidney disease chronic is a complex entity with significant morbidity and mortality relative to risk of fracture. Its prevalence is high, but the incrimination of clinical and biological factors remains poorly identified. The purpose of our study is to determine the prevalence and factors associated with osteoporosis. Methods: A cross-sectional study included 40 chronic hemodialysis patients for at least 6 months. All subjects underwent a bone mineral density (BMD) assay with dual-energy x-rays absorptiometry (DXA) at the lumbar spine (LS) and femoral neck (FN). Data were statistically analyzed by means of descriptive analysis. Patients were divided into 2 groups based on the T-score to define the osteoporotic (t score≤-2.5) and the no-osteoporotic (t score>-2.5). The search for the risk factors studied [age, duration of hemodialysis, parathyroid hormone (PTH), alkaline phosphatases (ALP), and calcification of the abdominal aorta (AAC)] has been carried out by logistic regression. Results: The average age was 59 ± 16 years, 47% were women, and the median of hemodialysis duration was 54 months. The prevalence of osteoporosis at the lumbar spine was 27.5% and at the femoral neck was 32.5%. Regarding risk factors, at the LS, the factors associated with osteoporosis retained in the univariate analysis were age (p=0.034), PTH (p=0.024), AAC (p=0.024), ALP (p=0.027) and in the multivariate analysis, only PTH was significantly associated (p=0.019). At the FN; The factors associated with osteoporosis retained in analysis univariate were age (p = 0.03), AAC (p = 0.01), ALP (p=0.04) and in analysis multivariate was the APL (p= 0.035). Conclusion: Osteoporosis is associated with turnover abnormalities. We suggest that regular screening for fracture risk using DXA and early correction of the disorders.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.36348/sjm.2024.v09i05.002
Amitabh Sarker, A. E. Kayesh, Masum Ahmed, M. Hoshen, Nabin Kundu, S. M. Saadi, G. Banik
Background: Stroke is a significant global health concern, particularly in countries like Bangladesh experiencing a rise in non-communicable diseases. The impact of stroke disabilities is profound, affecting both patients and their caregivers. Objective: This study aims to evaluate the role of caregivers in alleviating symptoms among post-stroke disabled individuals. Method: A two-arm, single-blind, randomized controlled trial was conducted over 12 weeks (July 2022-july 2023). 51 Participants, recruited from tertiary hospital departments, met specific eligibility criteria. They were assigned to either a control, n=26 or intervention group, n=25, receiving either standard care or a caregiver-mediated rehabilitation program, respectively. Assessments were conducted at baseline and endpoint, evaluating various functional and quality-of-life measures. Results: In the study, 30 out of 51 participants were male, constituting 58% of the sample, while the remaining 41% were female. Among the cohort, 24 individuals, making up 47% of the total sample, experienced right hemiplegia. Furthermore, a significant portion of the participants, 38 out of 51 individuals, accounting for 75%, resided in households featuring mobility obstacles such as raised doorsteps between rooms. Additionally, it was observed that 71% of the caregivers were spouses of the patients. In the intervention group, significant enhancements were observed in various domains of the Stroke Impact Scale (SIS), including strength, mobility, composite physical function, and general recovery, with p-values indicating statistical significance (< 0.001). Marginal improvements were also noted in the domains of activities of daily living (ADL)/instrumental activities of daily living (IADL), hand function, communication, and social participation, albeit with slightly higher p-values (0.022 to 0.030). Conversely, the control group did not exhibit significant within-group effects across these domains. When comparing caregiver burden scores between the control and intervention groups, although there were no statistically significant differences observed in the Total Burden, General Strain, and Disappointment domains, the Intervention Group displayed slight improvements in Isolation, Emotional, and Environment domains compared to the Control Group, despite these differences not reaching statistical significance. These findings indicate the multifaceted impact of the caregiver-mediated, home-based intervention on both post-stroke patients' functional outcomes and caregiver burden. Conclusion: Caregivers are essential in post-stroke care, and supporting them is vital for holistic patient support. The 12-week caregiver-mediated rehabilitation program demonstrated effectiveness in improving physical functional recovery, underscoring its practical value for chronic stroke patients.
{"title":"The Impact of Caregiver Support on Symptom Improvement in Post-Stroke Patients","authors":"Amitabh Sarker, A. E. Kayesh, Masum Ahmed, M. Hoshen, Nabin Kundu, S. M. Saadi, G. Banik","doi":"10.36348/sjm.2024.v09i05.002","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i05.002","url":null,"abstract":"Background: Stroke is a significant global health concern, particularly in countries like Bangladesh experiencing a rise in non-communicable diseases. The impact of stroke disabilities is profound, affecting both patients and their caregivers. Objective: This study aims to evaluate the role of caregivers in alleviating symptoms among post-stroke disabled individuals. Method: A two-arm, single-blind, randomized controlled trial was conducted over 12 weeks (July 2022-july 2023). 51 Participants, recruited from tertiary hospital departments, met specific eligibility criteria. They were assigned to either a control, n=26 or intervention group, n=25, receiving either standard care or a caregiver-mediated rehabilitation program, respectively. Assessments were conducted at baseline and endpoint, evaluating various functional and quality-of-life measures. Results: In the study, 30 out of 51 participants were male, constituting 58% of the sample, while the remaining 41% were female. Among the cohort, 24 individuals, making up 47% of the total sample, experienced right hemiplegia. Furthermore, a significant portion of the participants, 38 out of 51 individuals, accounting for 75%, resided in households featuring mobility obstacles such as raised doorsteps between rooms. Additionally, it was observed that 71% of the caregivers were spouses of the patients. In the intervention group, significant enhancements were observed in various domains of the Stroke Impact Scale (SIS), including strength, mobility, composite physical function, and general recovery, with p-values indicating statistical significance (< 0.001). Marginal improvements were also noted in the domains of activities of daily living (ADL)/instrumental activities of daily living (IADL), hand function, communication, and social participation, albeit with slightly higher p-values (0.022 to 0.030). Conversely, the control group did not exhibit significant within-group effects across these domains. When comparing caregiver burden scores between the control and intervention groups, although there were no statistically significant differences observed in the Total Burden, General Strain, and Disappointment domains, the Intervention Group displayed slight improvements in Isolation, Emotional, and Environment domains compared to the Control Group, despite these differences not reaching statistical significance. These findings indicate the multifaceted impact of the caregiver-mediated, home-based intervention on both post-stroke patients' functional outcomes and caregiver burden. Conclusion: Caregivers are essential in post-stroke care, and supporting them is vital for holistic patient support. The 12-week caregiver-mediated rehabilitation program demonstrated effectiveness in improving physical functional recovery, underscoring its practical value for chronic stroke patients.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.36348/sjm.2024.v09i05.001
K. Helael, A. Y. Mheidat, Mohammad Harbi Odat, Hudaib Nabeel Swalha, Anas Horani, Ra’ad Ahmad Al-omari, Mansour Mohanmmad Abushqair, Mohammad Ahmad Abu-Aloush, Mohammad Hamdi Ahmad Alhyari, Mut’az Jawher Alwadi, Yazan Mohammad Ahmad Al Momani, Habeeb lutfi Etewi
Atypical giant parathyroid adenoma is a rare tumor with unusual histological features, an unusual presentation of primary hyperparathyroidism but more elevated laboratory findings and more severe clinical presentation due to larger tissue mass, and defined as weighing>3.5 g, leading to diagnostic and therapeutic challenges. Herein, we report a case of a 56-year-old woman who presented with a palpable neck mass, fatigue, persistent hypercalcemia, osteoporosis and asymptomatic renal stones, Ultrasound showed a left-sided solid nodule, and Sestamibi nuclear scan showed a giant parathyroid adenoma. The diagnosis of giant atypical parathyroid adenoma was confirmed after surgical excision size (3.5*1.5cm). We discuss the investigations, treatment, and outcome of this rare case and highlight the importance of long-term follow-up care.
{"title":"Atypical Giant Parathyroid Adenoma, Case Report","authors":"K. Helael, A. Y. Mheidat, Mohammad Harbi Odat, Hudaib Nabeel Swalha, Anas Horani, Ra’ad Ahmad Al-omari, Mansour Mohanmmad Abushqair, Mohammad Ahmad Abu-Aloush, Mohammad Hamdi Ahmad Alhyari, Mut’az Jawher Alwadi, Yazan Mohammad Ahmad Al Momani, Habeeb lutfi Etewi","doi":"10.36348/sjm.2024.v09i05.001","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i05.001","url":null,"abstract":"Atypical giant parathyroid adenoma is a rare tumor with unusual histological features, an unusual presentation of primary hyperparathyroidism but more elevated laboratory findings and more severe clinical presentation due to larger tissue mass, and defined as weighing>3.5 g, leading to diagnostic and therapeutic challenges. Herein, we report a case of a 56-year-old woman who presented with a palpable neck mass, fatigue, persistent hypercalcemia, osteoporosis and asymptomatic renal stones, Ultrasound showed a left-sided solid nodule, and Sestamibi nuclear scan showed a giant parathyroid adenoma. The diagnosis of giant atypical parathyroid adenoma was confirmed after surgical excision size (3.5*1.5cm). We discuss the investigations, treatment, and outcome of this rare case and highlight the importance of long-term follow-up care.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":"14 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141009436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.36348/sjm.2024.v09i04.004
A. Dangana, Kadiri Khairat, Mujahideen Ayinde, Mangpin Leviticus Dansura, H. D. Nanbol, P. O. Ali, Bwede Eugene Samuel, Omoare A. A, Ale Toluwalese Ayokunmi, Nkiruka Lynda Uzoebo, Sunday Adagyo Oboshi, Nyiri Miriam Gyang, Muhammad Sani Usman
Background: Hypertension (HTN or HT), also known as high blood pressure or arterial hypertension, is a chronic medical condition in which the blood pressure in the arteries is elevated. Blood pressure is expressed by two measurements, the systolic and diastolic pressures. Purpose/Aim: To investigate the usefulness of C-reactive protein and ESR as biomarkers for the diagnosis of hypertension among hypertensive patients attending gwakor primary health centre. Methods: The study investigated the levels of ESR and CRP among hypertensive subjects. Qualitative and semi quantitative C-reactive protein was carried out on serum and ESR was also done using whole blood. Result: Of the 200 subjects recruited for the study the age distribution of C-reactive protein seropositivity among the study subjects shown that the age between 21-30 had a seropositivity 1(5.6%) with a total Number of 18 within the group, and the age group between 31-40 shown a seropositivity of 5(9.8%) with total number tested within the age group 51, also the age range between 41-50 shown a seropositivity of 6(24.0%) with total number tested to be 25, and the age range between 51-60 had no seropositivity with total number tested were 4, while >60yrs showed 2(100.0%) with total number tested were 2. the highest number of seropositivity observed was in the age range of >60yrs and above, followed by 41-50 with 24%. The highest value observed among the age group of >60yrs was not surprised because this age group are prone to degenerative diseases because of age related conditions as individual aged as shown in table 4.1. The difference observed among the age distribution of CRP seropositivity among the study subjects showed a significance difference which was statistically significant. The sex distribution among the study subject showed that men had seropositivity of 10(19.6%) with a total number of 51 tested, while female showed 4(8.2%) with total number of 49 tested. Conclusion: The findings in this study confirmed that CRP and ESR are good inflammatory markers in the management of hypertensive patients, also CRP is a more sensitive and specific marker compared to ESR, and it also reveal that as individual is aging the risk of developing hypertension is high because elderly people are more expose compared to younger persons.
{"title":"Comparative Analysis of C - reactive protein and Erythrocytes Sedimentation Rate among Hypertensive Patients Attending Gwako Primary Health Care Centre","authors":"A. Dangana, Kadiri Khairat, Mujahideen Ayinde, Mangpin Leviticus Dansura, H. D. Nanbol, P. O. Ali, Bwede Eugene Samuel, Omoare A. A, Ale Toluwalese Ayokunmi, Nkiruka Lynda Uzoebo, Sunday Adagyo Oboshi, Nyiri Miriam Gyang, Muhammad Sani Usman","doi":"10.36348/sjm.2024.v09i04.004","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i04.004","url":null,"abstract":"Background: Hypertension (HTN or HT), also known as high blood pressure or arterial hypertension, is a chronic medical condition in which the blood pressure in the arteries is elevated. Blood pressure is expressed by two measurements, the systolic and diastolic pressures. Purpose/Aim: To investigate the usefulness of C-reactive protein and ESR as biomarkers for the diagnosis of hypertension among hypertensive patients attending gwakor primary health centre. Methods: The study investigated the levels of ESR and CRP among hypertensive subjects. Qualitative and semi quantitative C-reactive protein was carried out on serum and ESR was also done using whole blood. Result: Of the 200 subjects recruited for the study the age distribution of C-reactive protein seropositivity among the study subjects shown that the age between 21-30 had a seropositivity 1(5.6%) with a total Number of 18 within the group, and the age group between 31-40 shown a seropositivity of 5(9.8%) with total number tested within the age group 51, also the age range between 41-50 shown a seropositivity of 6(24.0%) with total number tested to be 25, and the age range between 51-60 had no seropositivity with total number tested were 4, while >60yrs showed 2(100.0%) with total number tested were 2. the highest number of seropositivity observed was in the age range of >60yrs and above, followed by 41-50 with 24%. The highest value observed among the age group of >60yrs was not surprised because this age group are prone to degenerative diseases because of age related conditions as individual aged as shown in table 4.1. The difference observed among the age distribution of CRP seropositivity among the study subjects showed a significance difference which was statistically significant. The sex distribution among the study subject showed that men had seropositivity of 10(19.6%) with a total number of 51 tested, while female showed 4(8.2%) with total number of 49 tested. Conclusion: The findings in this study confirmed that CRP and ESR are good inflammatory markers in the management of hypertensive patients, also CRP is a more sensitive and specific marker compared to ESR, and it also reveal that as individual is aging the risk of developing hypertension is high because elderly people are more expose compared to younger persons.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.36348/sjm.2024.v09i04.005
H. Akter, Most. Nasrin, Tumpa Gharami
Background: Low back pain (LBP) is recognized as a major public health problem around the world and is one of the most frequently discussed health conditions among medical professionals, particularly in the field of nursing. In addition to the nature of nursing work, body mechanics and life style factors, nurses’ socio-demographic characteristics plays a significant role in the causation of this condition. As a result, the purpose of this study was to investigate the socio-demographic characteristics of nurses so that policymakers and healthcare practitioners could gain a better understanding into the mitigation of LBP among nurses. Methodology: This descriptive cross-sectional study was conducted among 80 nurses working at Mugda Medical College Hospital, Dhaka, Bangladesh. Face to face interview was conducted through a self-administered questionnaire which had three parts relatable to socio-demographic profile, screening of musculoskeletal problems and pain intensity. Both descriptive and inferential statistics was applied through SPSS to measure the socio-demographic characteristics of nurses and other major variables. Results: Results showed that the mean age and BMI was 37.53 years and 26.77, respectively. Further, 1.68 person, 82754.72 Bangladeshi taka and 16.17 years were found as the mean number of children, family monthly income and working experiences of nurses, respectively. BMI, marital status, number of children and working experiences were found to be significantly (p<.05) associated with the low back pain. Conclusion: Regardless of socioeconomic status, all nurses experience some level of low back pain. However, BMI, marital status, job years, and the number of children all have an impact on the development of low back pain in nurses.
{"title":"Socio-Demographic Characteristic of Low Back Pain among Nurses Working at a Medical College Hospital in Dhaka, Bangladesh","authors":"H. Akter, Most. Nasrin, Tumpa Gharami","doi":"10.36348/sjm.2024.v09i04.005","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i04.005","url":null,"abstract":"Background: Low back pain (LBP) is recognized as a major public health problem around the world and is one of the most frequently discussed health conditions among medical professionals, particularly in the field of nursing. In addition to the nature of nursing work, body mechanics and life style factors, nurses’ socio-demographic characteristics plays a significant role in the causation of this condition. As a result, the purpose of this study was to investigate the socio-demographic characteristics of nurses so that policymakers and healthcare practitioners could gain a better understanding into the mitigation of LBP among nurses. Methodology: This descriptive cross-sectional study was conducted among 80 nurses working at Mugda Medical College Hospital, Dhaka, Bangladesh. Face to face interview was conducted through a self-administered questionnaire which had three parts relatable to socio-demographic profile, screening of musculoskeletal problems and pain intensity. Both descriptive and inferential statistics was applied through SPSS to measure the socio-demographic characteristics of nurses and other major variables. Results: Results showed that the mean age and BMI was 37.53 years and 26.77, respectively. Further, 1.68 person, 82754.72 Bangladeshi taka and 16.17 years were found as the mean number of children, family monthly income and working experiences of nurses, respectively. BMI, marital status, number of children and working experiences were found to be significantly (p<.05) associated with the low back pain. Conclusion: Regardless of socioeconomic status, all nurses experience some level of low back pain. However, BMI, marital status, job years, and the number of children all have an impact on the development of low back pain in nurses.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140688734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-13DOI: 10.36348/sjm.2024.v09i04.003
Mona M. S. Salama, Mahdi H. A. Abdalla, Nasr Eldeen Ali Mohammed Gaufri
Sickle cell anaemia (SCA) is an inherited blood disorder that is characterized by chronic haemolysis and episodes of many clinical complications. The number of people living with sickle cell disease globally increased from 5.46 million in 2000 to 7.74 million in 2021. This study aimed to investigate the association of glutathione S transferase M1, T1, P1 (GSTM1, GSTT1, GSTP1) gene polymorphisms with SCA complications. This was a case-control and hospital-based study, conducted in the SCA center, Alkuaiti Hospital, North Kordofan state, Sudan. Following informed consent, one hundred twenty-six participants were recruited to this study, 63 were SCA patients attending Alkuaiti Hospital, and 63 age and gender matched apparently healthy individuals as the control group. The full blood count was done using an automated hematological analyzer, genotyping of the GSTM1 and the GSTT1 polymorphisms were determined using multiplex polymerase chain reaction, while genotyping of the GSTP1 was determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Complications data were collected from admission and discharge records. 52.4% (n=33) from the case group were male and 47.6% (n=30) were females. The GSTM1 genotypes in the case group showed that the frequency of the GSTM1Null genotype was 57.1% and the GSTM1 present genotype was 42.9%, the GSTM1 genotypes in the control group showed that the frequency of the GSTM1Null genotype was 52.4% and the GSTM1 present genotype was 47.6%. The GSTT1 genotypes in the case group showed that the frequency of the GSTT1 Null genotype was 69.8%, and the GSTT1 present genotype was 30.2%. The GSTT1 genotypes in the control group showed that the frequency of the GSTT1 Null genotype was 49.8%, and the GSTT1 present genotype was 50.2%. The GSTM1 GSTT1 genotypes in the case group showed that the frequency of the GSTM1 GSTT1 Null genotype was 74.6%, and the GSTM1 GSTT1 present genotype was 25.4%. The GSTM1 GSTT1 genotypes in the control group showed that the frequency of the GSTM1 GSTT1 Null genotype was 77.7% and the GSTM1 GSTT1 present genotype was 22.3%. The GSTP1 genotype in the case group showed that the wild-type Ile/Ile was (15.9%), the heterozygous Ile/Val was (66.7%), and the homozygous mutant Val/Val was (17.4%). The GSTP1 genotype in the control group showed that the wild-type Ile/Ile was (3.2%), the heterozygous Ile/Val was (84.1%), and the homozygous mutant Val/Val was (12.7%). There were no statistically significant differences in the Hb, TWBCs, and PLTs between the GSTM1 genotypes (P.value =0.69, 0.47, 0.22) respectively also there were no statistically significant differences in the Hb, TWBCs, and PLTs between the GSTT1 genotypes (P.value = 0.84, 0.45, 0.48) respectively and the GSTM1 GSTT1 genotypes (P.value= 0.53, 0.70, 0.46) respectively. There were no statistically significant differences in the Hb, and TWBCs between the GSTP1 genotypes (P.value= 0.15, 0.36) respectively b
{"title":"Association of Glutathione S Transferase M1, T1, P1 (GSTM1, GSTT1, GSTP1) Gene Polymorphisms with Sickle Cell Anaemia Complications in North Kordofan State, Sudan","authors":"Mona M. S. Salama, Mahdi H. A. Abdalla, Nasr Eldeen Ali Mohammed Gaufri","doi":"10.36348/sjm.2024.v09i04.003","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i04.003","url":null,"abstract":"Sickle cell anaemia (SCA) is an inherited blood disorder that is characterized by chronic haemolysis and episodes of many clinical complications. The number of people living with sickle cell disease globally increased from 5.46 million in 2000 to 7.74 million in 2021. This study aimed to investigate the association of glutathione S transferase M1, T1, P1 (GSTM1, GSTT1, GSTP1) gene polymorphisms with SCA complications. This was a case-control and hospital-based study, conducted in the SCA center, Alkuaiti Hospital, North Kordofan state, Sudan. Following informed consent, one hundred twenty-six participants were recruited to this study, 63 were SCA patients attending Alkuaiti Hospital, and 63 age and gender matched apparently healthy individuals as the control group. The full blood count was done using an automated hematological analyzer, genotyping of the GSTM1 and the GSTT1 polymorphisms were determined using multiplex polymerase chain reaction, while genotyping of the GSTP1 was determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Complications data were collected from admission and discharge records. 52.4% (n=33) from the case group were male and 47.6% (n=30) were females. The GSTM1 genotypes in the case group showed that the frequency of the GSTM1Null genotype was 57.1% and the GSTM1 present genotype was 42.9%, the GSTM1 genotypes in the control group showed that the frequency of the GSTM1Null genotype was 52.4% and the GSTM1 present genotype was 47.6%. The GSTT1 genotypes in the case group showed that the frequency of the GSTT1 Null genotype was 69.8%, and the GSTT1 present genotype was 30.2%. The GSTT1 genotypes in the control group showed that the frequency of the GSTT1 Null genotype was 49.8%, and the GSTT1 present genotype was 50.2%. The GSTM1 GSTT1 genotypes in the case group showed that the frequency of the GSTM1 GSTT1 Null genotype was 74.6%, and the GSTM1 GSTT1 present genotype was 25.4%. The GSTM1 GSTT1 genotypes in the control group showed that the frequency of the GSTM1 GSTT1 Null genotype was 77.7% and the GSTM1 GSTT1 present genotype was 22.3%. The GSTP1 genotype in the case group showed that the wild-type Ile/Ile was (15.9%), the heterozygous Ile/Val was (66.7%), and the homozygous mutant Val/Val was (17.4%). The GSTP1 genotype in the control group showed that the wild-type Ile/Ile was (3.2%), the heterozygous Ile/Val was (84.1%), and the homozygous mutant Val/Val was (12.7%). There were no statistically significant differences in the Hb, TWBCs, and PLTs between the GSTM1 genotypes (P.value =0.69, 0.47, 0.22) respectively also there were no statistically significant differences in the Hb, TWBCs, and PLTs between the GSTT1 genotypes (P.value = 0.84, 0.45, 0.48) respectively and the GSTM1 GSTT1 genotypes (P.value= 0.53, 0.70, 0.46) respectively. There were no statistically significant differences in the Hb, and TWBCs between the GSTP1 genotypes (P.value= 0.15, 0.36) respectively b","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":"40 162","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.36348/sjm.2024.v09i04.002
Ayoub El Massnaoui, Sami Amraoui, N. Sellal, M. El Hfid
This case report describes the successful treatment of a squamous cell carcinoma (SCC) of the lip with brachytherapy in a 36-year-old man. The patient presented with a 03 cm ulcerated lesion on the lower lip classified as T2N0, which biopsy confirmed to be SCC. Due to the location of the lesion and the patient's preference for minimally invasive treatment, brachytherapy was chosen. The patient received 40.05Gray, 4.5 Gray per session in 09 sessions. Follow-up examinations showed complete resolution of the lesion with minimal adverse effects. This case highlights the efficacy, tolerability and good esthetic result of brachytherapy in the treatment of SCC of the lip.
{"title":"A Case Report of Successful Treatment of Squamous Cell Carcinoma with Excellent Esthetic Results","authors":"Ayoub El Massnaoui, Sami Amraoui, N. Sellal, M. El Hfid","doi":"10.36348/sjm.2024.v09i04.002","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i04.002","url":null,"abstract":"This case report describes the successful treatment of a squamous cell carcinoma (SCC) of the lip with brachytherapy in a 36-year-old man. The patient presented with a 03 cm ulcerated lesion on the lower lip classified as T2N0, which biopsy confirmed to be SCC. Due to the location of the lesion and the patient's preference for minimally invasive treatment, brachytherapy was chosen. The patient received 40.05Gray, 4.5 Gray per session in 09 sessions. Follow-up examinations showed complete resolution of the lesion with minimal adverse effects. This case highlights the efficacy, tolerability and good esthetic result of brachytherapy in the treatment of SCC of the lip.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":"14 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-06DOI: 10.36348/sjm.2024.v09i04.001
Md. Abdullah-Al-Maruf Md. Abdullah-Al-Maruf, Md. Ruhid Hossain, A.H.M. Anisuzzaman, Alamgir Hossan,, Abu Naser Md Abdul Kader, Jiban Chandra Das, Noor Mohammed
Background: Tobacco consumption, encompassing both smoking and smokeless forms, remains a significant public health challenge globally, particularly prevalent in rural areas of Bangladesh. Despite efforts to curb its usage, tobacco continues to impose a substantial burden on public health, socioeconomic development, and community well-being, especially in rural regions. Objective: This study aims to assess the prevalence of tobacco use among rural areas of Bangladesh, exploring factors driving its uptake and persistence. Method: Between January and June 2023, a cross-sectional epidemiological investigation took place across multiple regions in Bangladesh, spanning Sylhet, Shunamgonj, Moulvibazar, Hobigonj, Chattogram, Pabna, Brahman Baria, Kishorgonj, and Chandpur districts. The study targeted a randomized selection of 250 adults aged 18 years and above, who had resided in their respective areas for at least five years. These individuals were recruited during consultations for various health concerns. Subsequently, they were surveyed regarding their history of tobacco consumption, and with their consent, data was systematically collected using structured questionnaires, physical assessments, and anthropometric measurements. The gathered data underwent statistical analysis through SPSS v. 20.0. Results: The study revealed a diverse demographic profile, with a majority falling within the 18-39 age bracket (40%) and a slight predominance of males (55%). Educational attainment varied, with 50% having primary dropout status. Regarding tobacco use, 30% reported smoking bidi, cigarettes, or self-rolled tobacco, 50% were non-smokers, and 20% used both smoking and non-smoking forms. The onset of tobacco use varied, with 30% starting after the age of 30. Association of impact of chronic long term tobacco use on health was also significant with 76% long term users having health related issues. Additionally, 30% of tobacco users engaged in other forms of recreation, while 25% attempted to quit smoking. Limited psychiatric awareness was evident, with only 10% understanding psychiatric disorders. Conclusion: The study highlights the significant prevalence of tobacco use in rural Bangladesh and underscores the urgent need for comprehensive strategies to address this public health issue. Targeted interventions and evidence-based policies are essential to mitigate the adverse effects of tobacco use, safeguard public health, and promote healthier communities in rural areas.
{"title":"Prevalence of Tobacco Users (Smoking and Smokeless) among Rural Areas in Bangladesh","authors":"Md. Abdullah-Al-Maruf Md. Abdullah-Al-Maruf, Md. Ruhid Hossain, A.H.M. Anisuzzaman, Alamgir Hossan,, Abu Naser Md Abdul Kader, Jiban Chandra Das, Noor Mohammed","doi":"10.36348/sjm.2024.v09i04.001","DOIUrl":"https://doi.org/10.36348/sjm.2024.v09i04.001","url":null,"abstract":"Background: Tobacco consumption, encompassing both smoking and smokeless forms, remains a significant public health challenge globally, particularly prevalent in rural areas of Bangladesh. Despite efforts to curb its usage, tobacco continues to impose a substantial burden on public health, socioeconomic development, and community well-being, especially in rural regions. Objective: This study aims to assess the prevalence of tobacco use among rural areas of Bangladesh, exploring factors driving its uptake and persistence. Method: Between January and June 2023, a cross-sectional epidemiological investigation took place across multiple regions in Bangladesh, spanning Sylhet, Shunamgonj, Moulvibazar, Hobigonj, Chattogram, Pabna, Brahman Baria, Kishorgonj, and Chandpur districts. The study targeted a randomized selection of 250 adults aged 18 years and above, who had resided in their respective areas for at least five years. These individuals were recruited during consultations for various health concerns. Subsequently, they were surveyed regarding their history of tobacco consumption, and with their consent, data was systematically collected using structured questionnaires, physical assessments, and anthropometric measurements. The gathered data underwent statistical analysis through SPSS v. 20.0. Results: The study revealed a diverse demographic profile, with a majority falling within the 18-39 age bracket (40%) and a slight predominance of males (55%). Educational attainment varied, with 50% having primary dropout status. Regarding tobacco use, 30% reported smoking bidi, cigarettes, or self-rolled tobacco, 50% were non-smokers, and 20% used both smoking and non-smoking forms. The onset of tobacco use varied, with 30% starting after the age of 30. Association of impact of chronic long term tobacco use on health was also significant with 76% long term users having health related issues. Additionally, 30% of tobacco users engaged in other forms of recreation, while 25% attempted to quit smoking. Limited psychiatric awareness was evident, with only 10% understanding psychiatric disorders. Conclusion: The study highlights the significant prevalence of tobacco use in rural Bangladesh and underscores the urgent need for comprehensive strategies to address this public health issue. Targeted interventions and evidence-based policies are essential to mitigate the adverse effects of tobacco use, safeguard public health, and promote healthier communities in rural areas.","PeriodicalId":510088,"journal":{"name":"Saudi Journal of Medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140735528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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