International Journal of Eating Disorders最新文献_第8页

Predictors of Treatment Outcome in an Early Intervention Eating Disorder Sample. 进食障碍早期干预样本治疗结果的预测因素。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-11-10 DOI: 10.1002/eat.24593

Karina L Allen, Amelia Austin, Michaela Flynn, Danielle Glennon, Victoria A Mountford, Amy Brown, Mary Franklin-Smith, William Rhys Jones, Gabrielle Brady, Nicole Nunes, Frances Connan, Kate Mahony, Lucy Serpell, Ulrike Schmidt

Objective: To examine baseline predictors of treatment completion and clinical outcomes in 16 to 25-year-olds referred for early intervention for a recent-onset eating disorder (ED).

Method: Participants (n = 228; 93% female, 63% White British) were drawn from the FREED-Up study, which evaluated First episode Rapid Early intervention for EDs (FREED) in England across 2017-2018. Measures were completed at baseline and 3-, 6- and 12-months. Generalized estimating equations were used to identify baseline predictors of treatment completion and symptom remission by 12-months. Linear mixed models were used to identify baseline predictors of change in global eating disorder examination-questionnaire (EDE-Q) scores, binge eating, purging and BMI (anorexia nervosa [AN] only) over 12-months. Possible predictors included baseline ED symptoms, depression, anxiety, stress, psychosocial impairment, expressed emotion from close others, functioning against personalized goals, age, ethnicity, duration of illness, waiting times and BMI.

Results: There were no significant predictors of treatment completion. Lower stress at baseline predicted increased likelihood of symptom remission by 12 months. Lower purging and psychosocial impairment at baseline predicted lower Global EDE-Q scores over the following 12 months; lower purging predicted lower rates of binge eating; and lower Global EDE-Q scores, binge eating and assessment waiting times predicted lower rates of purging. Higher purging at baseline was associated with higher BMI in AN.

Discussion: This study provides new data on predictors of treatment outcomes in an early intervention ED sample. In addition to ED symptoms and waiting times, psychosocial impairment and stress warrant consideration as factors that may influence treatment outcomes.

目的：研究16 - 25岁新近发病的饮食失调（ED）患者早期干预治疗完成度和临床结果的基线预测因素。方法：从freedup研究中抽取参与者（n = 228； 93%为女性，63%为英国白人），该研究评估了2017-2018年英格兰ed的首次快速早期干预（FREED）。在基线、3个月、6个月和12个月完成测量。使用广义估计方程来确定12个月治疗完成和症状缓解的基线预测因子。线性混合模型用于确定12个月内全球饮食失调检查问卷（ed -q）评分、暴食、排便和BMI（仅神经性厌食症[AN]）变化的基线预测因子。可能的预测因素包括基线ED症状、抑郁、焦虑、压力、心理障碍、来自亲密他人的情感表达、对个性化目标的功能、年龄、种族、疾病持续时间、等待时间和BMI。结果：没有显著的治疗完成的预测因素。基线时较低的压力预示着12个月后症状缓解的可能性增加。基线时较低的净化和社会心理障碍预示着在接下来的12个月里较低的全球ed - q评分；较低的排便率预示着较低的暴食率；较低的全球ed - q评分、暴饮暴食和评估等待时间预示着较低的排便率。基线时较高的排气量与AN患者较高的BMI相关。讨论：本研究提供了早期干预ED样本治疗结果预测因子的新数据。除了ED症状和等待时间外，社会心理障碍和压力也可能是影响治疗结果的因素。

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引用次数: 0

Body Image Surveys to Address Social Appearance Anxiety in Women at Risk of Eating Psychopathology: An Acceptability, Feasibility and Preliminary Efficacy Study, Using a Wait-List Randomized Controlled Design 身体形象调查解决有饮食精神病理风险的女性的社会外表焦虑：一项可接受性、可行性和初步疗效研究，采用等候名单随机对照设计。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-11-05 DOI: 10.1002/eat.24590

Emma Giles, Glenn Waller

Objective

The study investigated the feasibility, acceptability and preliminary efficacy of a body image survey intervention for women at risk of eating psychopathology.

Method

A randomized wait-list control design was used. The preregistered study (https://doi.org/10.17605/OSF.IO/ZQPEU) had ethical clearance and met recruitment targets. Female participants (aged 18–48 years) with high levels of social appearance anxiety (i.e., deemed at risk of eating pathology) were recruited via advertisement. Thirty-one participants completed the intervention, with 15 participants randomly allocated to the immediate treatment condition and 16 to the wait-list condition. The intervention consisted of two thirty-minute sessions over a week. Self-report measures were administered every week for 3 weeks and then at the follow-up 4 weeks later. Acceptability was defined as over 75% of participants completing the study and an average score above 5 on a 7-point Likert scale assessing acceptability. Feasibility was defined as over 60 participants expressing interest in the study, over 75% of participants consenting to intervention, and over 30 participants recruited for the intervention.

Results

The wait-list control design met all criteria for feasibility and acceptability. Preliminary outcomes (completer and intention-to-treat analyses) suggest body image surveys are effective at reducing social appearance anxiety (d = 1.79). While eating psychopathology and body image distress reduced over time, no significant interactions with group were found.

Discussion

While a full trial is needed to add to this evidence, body image surveys appear to be an acceptable and beneficial treatment for people with high levels of social appearance anxiety.

目的：探讨身体形象调查干预饮食精神病理风险女性的可行性、可接受性及初步效果。方法：采用随机等候名单对照设计。预注册研究（https://doi.org/10.17605/OSF.IO/ZQPEU）已通过伦理审查并达到招募目标。女性参与者（18-48岁）有高度的社交外表焦虑（即，被认为有饮食病理学的风险）是通过广告招募的。31名参与者完成了干预，其中15名参与者被随机分配到立即治疗组，16名参与者被分配到等待名单组。干预包括每周两次30分钟的会议。每周进行自我报告测量，持续3周，然后在4周后进行随访。可接受性被定义为超过75%的参与者完成了研究，并且在7分李克特量表评估可接受性的平均得分超过5分。可行性定义为超过60名参与者表示对研究感兴趣，超过75%的参与者同意干预，超过30名参与者被招募参与干预。结果：等候名单对照设计符合可行性和可接受性的所有标准。初步结果（完成率和意向治疗分析）表明，身体形象调查在减少社交外表焦虑方面是有效的（d = 1.79）。虽然随着时间的推移，饮食心理病理和身体形象困扰有所减少，但没有发现与小组的显著相互作用。讨论：虽然需要一个完整的试验来补充这一证据，但身体形象调查似乎是一种可接受的、有益的治疗方法，可以治疗高度社交形象焦虑的人。

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引用次数: 0

The Relationship Between Precuneus Thickness and Psychopathology in Adolescent Females With Anorexia Nervosa 青春期女性神经性厌食症楔前叶厚度与精神病理的关系。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-11-03 DOI: 10.1002/eat.24591

Irina Jarvers, Raphael Degmayr, Alexandra Otto, Ricarda Jacob, Wilhelm Malloni, Stephanie Kandsperger, Daniel Schleicher, Angelika Ecker, Isabel Wiesinger, Christina Wendl, Mark Greenlee, Romuald Brunner

Objective

Anorexia nervosa (AN) is a severe psychiatric disorder with structural brain alterations; however, the roles of cortical surface area (CSA) and cortical thickness (CTh) during adolescence remain unclear. Building on frequent reports of gray matter reductions in the cingulate cortex and precuneus, this study assesses CSA, CTh, and cortical volume in these regions, alongside exploratory whole-brain analyses and their associations with psychological dimensions.

Method

We included 26 adolescent females aged 12–19 years with acute AN and 24 age-matched healthy controls. Participants underwent high-resolution structural MRI and completed psychological assessments: Eating Disorder Inventory-2 (EDI-II), Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), Perth Alexithymia Questionnaire (PAQ), and Body Perception Questionnaire. MRI data were processed using BIDScoin, fMRIPrep, and FreeSurfer. Analyses included permutation-based non-parametric testing and multiple regression to investigate associations between brain metrics and psychological scores.

Results

In primary analyses, individuals with AN exhibited a significant reduction in precuneus CTh only. Precuneus CTh correlated negatively with EDI-II, BAI, and BDI-II scores, and positively with BMI-SDS. Regression analysis identified anxiety (BAI), specific EDI-II subscales, supra-diaphragmatic autonomic reactivity and difficulties describing negative feelings (PAQ) as predictors of precuneus CTh. Exploratory analyses revealed thickness differences in parietal and frontal regions, consistent with prior large-scale studies, with anxiety and depression scores correlating with several of these regions.

Discussion

Reduced precuneus CTh and its association with psychological factors highlight its role in AN's neurobiological mechanisms. Exploratory findings implicate parietal and frontal alterations, suggesting broader disruptions in body perception and behavioral control.

目的：神经性厌食症（Anorexia neurovosa， AN）是一种伴有大脑结构改变的严重精神障碍；然而，皮质表面积（CSA）和皮质厚度（CTh）在青春期的作用尚不清楚。基于对扣带皮层和楔前叶灰质减少的频繁报道，本研究评估了这些区域的CSA、CTh和皮质体积，同时进行了探索性全脑分析及其与心理维度的关联。方法：我们纳入了26名年龄在12-19岁的急性AN青少年女性和24名年龄匹配的健康对照。参与者接受高分辨率结构MRI检查，并完成心理评估：饮食失调量表-2 （edii - ii）、贝克焦虑量表（BAI）、贝克抑郁量表- ii （BDI-II）、珀斯述情障碍问卷（PAQ）和身体感知问卷。MRI数据使用BIDScoin、fMRIPrep和FreeSurfer进行处理。分析包括基于排列的非参数检验和多元回归，以调查大脑指标和心理评分之间的关系。结果：在初步分析中，AN患者仅表现出楔前叶CTh的显著减少。楔前叶CTh与EDI-II、BAI和BDI-II评分呈负相关，与BMI-SDS呈正相关。回归分析发现，焦虑（BAI）、特定的edii - ii亚量表、膈上自主神经反应性和描述负面感受困难（PAQ）是楔前叶CTh的预测因子。探索性分析揭示了顶叶和额叶区域的厚度差异，与之前的大规模研究一致，焦虑和抑郁得分与这些区域中的几个相关。讨论：楔前叶CTh减少及其与心理因素的关联突出了其在AN神经生物学机制中的作用。探索性发现涉及顶叶和额叶的改变，表明在身体感知和行为控制方面更广泛的中断。

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引用次数: 0

Clinicians' Experiences of Providing Compulsory Care for Youth With Anorexia Nervosa: A Qualitative Study 临床医生对青少年神经性厌食症强制护理的经验：一项质性研究。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-11-03 DOI: 10.1002/eat.24587

T. M. Offringa, R. R. J. M. Vermeiren, C. Bouman, M. C. de Vries, H. G. J. M. Vermetten, P. M. L. Korthals Altes, L. A. Nooteboom

Objective

While compulsory treatment is shown to be potentially traumatic for patients, its impact on clinicians has been insufficiently studied. This study aimed to examine clinicians' experiences with providing compulsory nasogastric tube feeding for youth with severe anorexia nervosa, with particular attention to identifying factors contributing to its negative impacts and potential areas for improvement in clinical practice.

Method

Twenty-three clinicians in various roles from four academic child and adolescent psychiatry clinics in the Netherlands shared their experiences and opinions regarding compulsory nasogastric tube feeding for youth with anorexia nervosa in semi-structured interviews. Thematic analysis was conducted after systematic deductive and inductive coding based on a framework of theory and practice.

Results

Three themes were identified. First, clinicians illustrated the immense impact of providing compulsory feeding and how this varied between different roles within a team. Second, the clinicians described myriad situations of highly distressing and potentially traumatic physical, and especially verbal resistance by patients and sometimes their parents. Third, the clinicians underlined the value of an emotionally safe working environment, the need for clear practical guidelines and the necessity of ethical debate.

Discussion

Providing compulsory nasogastric tube feeding for youth with anorexia nervosa may potentially cross clinicians' moral boundaries, leading to moral injury and potential traumatization, endangering the quality and sustainability of care. The necessity for education, innovation, team building, shared decision-making, practical guidelines and ethical/moral debate is discussed. This study may contribute to ongoing debate and further research on the implications of compulsory feeding for youth with anorexia nervosa.

目的：虽然强制治疗被证明对患者有潜在的创伤，但它对临床医生的影响尚未得到充分的研究。本研究旨在探讨临床医生为青少年重度神经性厌食症患者提供强制鼻胃管喂养的经验，并特别注意识别导致其负面影响的因素和临床实践中可能需要改进的领域。方法：采用半结构化访谈的方式，对荷兰四家儿童青少年精神病学学术诊所的23名不同角色的临床医生进行访谈，分享了他们对青少年神经性厌食症强制鼻胃管喂养的经验和看法。在理论与实践的框架下，通过系统的演绎与归纳编码进行主题分析。结果：确定了三个主题。首先，临床医生说明了提供强制喂养的巨大影响，以及团队中不同角色之间的差异。其次，临床医生描述了无数非常痛苦和潜在创伤的身体状况，尤其是患者（有时是他们的父母）的语言抵抗。第三，临床医生强调了情感安全工作环境的价值，明确实用指导方针的必要性以及道德辩论的必要性。讨论：为青少年神经性厌食症患者提供强制鼻胃管喂养可能会跨越临床医生的道德界限，导致道德伤害和潜在的创伤，危及护理的质量和可持续性。讨论了教育、创新、团队建设、共同决策、实践指南和伦理/道德辩论的必要性。这项研究可能有助于正在进行的辩论和进一步研究强制性喂养对青少年神经性厌食症的影响。

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引用次数: 0

Transdiagnostic Approaches Across Eating Disorders, Depression, Anxiety and Suicidality and Other Comorbidities 跨饮食失调、抑郁、焦虑、自杀和其他共病的跨诊断方法。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-10-31 DOI: 10.1002/eat.24589

Tracey D. Wade, Bridianne O'Dea

There is an increased interest in targeting transdiagnostic processes in the prevention, early intervention and treatment of mental illness. Targeting transdiagnostic processes may produce more acceptable, engaging, and efficient approaches to addressing mental health disorders, including eating disorders. Given the high prevalence of comorbidities, transdiagnostic approaches may have broader reach, uptake and adoption in real-world applications and clinical practice. Transdiagnostic models may be particularly well-suited to young people, who often present with shifting symptom profiles and are embedded within complex family and education systems. Identification of shared transdiagnostic processes among eating disorders, depression, anxiety, and suicidality and other common comorbid conditions will inform the development of future mental health interventions. To assist in facilitating further research, the International Journal of Eating Disorders will devote a special issue to this topic.

在精神疾病的预防、早期干预和治疗中，针对跨诊断过程的兴趣越来越大。针对跨诊断过程可能会产生更可接受、更有吸引力和更有效的方法来解决心理健康障碍，包括饮食失调。鉴于合并症的高患病率，跨诊断方法可能在现实世界的应用和临床实践中有更广泛的范围、吸收和采用。跨诊断模式可能特别适合年轻人，他们往往表现出变化的症状特征，并植根于复杂的家庭和教育系统。确定饮食失调、抑郁、焦虑、自杀和其他常见合并症之间的共同跨诊断过程，将为未来心理健康干预措施的发展提供信息。为了促进进一步的研究，《国际饮食失调杂志》将为此主题专门出版一期。

引用次数: 0

The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms in the Adult General Population of the UK and USA 英国和美国成年人群中回避/限制性食物摄入障碍（ARFID）症状的患病率和负担

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-10-29 DOI: 10.1002/eat.24588

Grace Brownlow, Rosie Flack, Helen Burton-Murray, Olafur Palsson, Imran Aziz

Introduction

Avoidant/Restrictive Food Intake Disorder (ARFID) is a feeding and eating disorder characterized by avoidant/restrictive eating behaviors that lead to medical and/or functional impairments. While ARFID is increasingly recognized within pediatric populations and specialist clinics, data on its prevalence and burden within the adult general population remain sparse. We sought to address this knowledge gap.

Methods

We conducted a population-based internet survey with predefined demographic quotas across the UK and USA. The survey included the Nine-Item ARFID Screen (NIAS), the Rome IV diagnostic questionnaire for disorders of gut-brain interaction (e.g., irritable bowel syndrome, functional dyspepsia), and questions regarding demographics, body mass index, somatic symptoms, anxiety and depression, quality of life, and healthcare utilization.

Results

Among 4002 participants (mean age 47.1 years, 50% female), 26.0% screened positive for ARFID. Prevalence was significantly higher in females versus males (29.6% vs. 22.1%, OR 1.48, 95% CI 1.28–1.71) and varied by age: 18–39 years (31.6%), 40–64 years (25.0%), and ≥ 65 years (16.1%; p < 0.001). Participants with a positive ARFID screen demonstrated significantly higher rates of underweight status, disorders of gut-brain interaction, mood disturbances, somatic symptoms, reduced mental and physical quality of life, and increased healthcare utilization compared to unaffected individuals. Increasing severity of ARFID correlated with greater general health impairment (all p < 0.001).

Conclusion

A positive ARFID screen is common within the adult general population, affecting 1-in-4 people, and associated with a substantial health burden. Increased awareness of ARFID will facilitate clinical service provision and guide future research.

回避/限制性食物摄入障碍（ARFID）是一种进食障碍，以回避/限制性饮食行为为特征，导致医疗和/或功能障碍。虽然ARFID在儿科人群和专科诊所中得到越来越多的认可，但关于其在成人普通人群中的患病率和负担的数据仍然很少。我们试图解决这一知识鸿沟。方法：我们在英国和美国进行了一项基于人口的网络调查，并预先设定了人口配额。该调查包括九项ARFID筛选（NIAS），肠-脑相互作用紊乱（如肠易激综合征、功能性消化不良）的罗马IV诊断问卷，以及有关人口统计学、体重指数、躯体症状、焦虑和抑郁、生活质量和医疗保健利用的问题。结果：在4002名参与者中（平均年龄47.1岁，50%为女性），26.0%的ARFID筛查呈阳性。女性的患病率明显高于男性（29.6%对22.1%,OR 1.48, 95% CI 1.28-1.71），并因年龄而异：18-39岁（31.6%）、40-64岁（25.0%）和≥65岁（16.1%）；p结论：ARFID筛查阳性在成人一般人群中很常见，影响1 / 4的人，并与重大健康负担相关。提高对ARFID的认识将促进临床服务的提供并指导未来的研究。

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引用次数: 0

Addressing the Negative Impact of Social Media on Body Image: An Online Randomized Controlled Pilot Trial 解决社交媒体对身体形象的负面影响：一项在线随机对照试点试验。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-10-28 DOI: 10.1002/eat.24584

Gritt Ladwig, Kristine Schönhals, Hannah L. Quittkat, Fanny Alexandra Dietel, Silja Vocks

Objective

Previous research has revealed negative effects of appearance-related social media content, such as fitspiration, on body satisfaction. However, specific interventions to reduce these detrimental effects are scarce. Therefore, this randomized controlled pilot trial investigated the efficacy of the four-week online intervention body image booster (BIBo), which aims to reduce the negative influence of social media on body image by addressing theoretically proposed underlying mechanisms.

Method

N = 157 female participants with elevated eating disorder (ED) symptoms were randomly allocated to the BIBo training or a waitlist control condition (WLC). The final sample included n = 38 completers in the BIBo training group and n = 46 completers in the WLC. Before and after the four training sessions, ED symptoms and reactivity to fitspiration content were assessed, as well as body dissatisfaction, social comparison processes, and internalization of body ideals.

Results

BIBo participants showed significant pre-post reductions in ED symptoms (d = −0.72) and reactivity to fitspiration content (d = −0.58), while WLC participants showed no significant change. The same pattern of results emerged for upward social comparison (d = −0.59), appearance comparison on social media (d = −0.89), body dissatisfaction (d = −0.40), and internalization of a thin body ideal (d = −0.42). There were no pre-post changes in internalization of muscularity or attractiveness ideals in either the BIBo or the WLC group.

Discussion

Overall, the results suggest that BIBo is effective in altering pertinent outcome and mechanistic measures related to social media use and body image, demonstrating its therapeutic potential in the prevention and treatment of EDs.

目的：之前的研究已经揭示了与外表相关的社交媒体内容（如fitspiration）对身体满意度的负面影响。然而，减少这些有害影响的具体干预措施很少。因此，本随机对照先导试验研究了为期四周的在线干预body image booster （BIBo）的有效性，旨在通过解决理论上提出的潜在机制来减少社交媒体对身体形象的负面影响。方法：N = 157名饮食失调（ED）症状升高的女性受试者被随机分配到BIBo训练组或候补控制组（WLC）。最终样本包括BIBo训练组n = 38名完成者和WLC组n = 46名完成者。在四次训练之前和之后，评估ED症状和对汗水含量的反应，以及身体不满，社会比较过程和身体理想的内化。结果：BIBo参与者在ED症状（d = -0.72）和对汗液含量的反应性（d = -0.58）方面表现出显著的前后减轻，而WLC参与者没有表现出显著的变化。向上的社会比较（d = -0.59）、社交媒体上的外表比较（d = -0.89）、身材不满（d = -0.40）和瘦身材理想的内化（d = -0.42）也出现了同样的结果模式。在BIBo组和WLC组中，对肌肉力量和吸引力理想的内化在前后没有变化。讨论：总体而言，结果表明BIBo在改变与社交媒体使用和身体形象相关的相关结果和机制措施方面是有效的，显示了其在预防和治疗ed方面的治疗潜力。

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引用次数: 0

Effects of GLP-1 Receptor Agonist Therapy on Eating Disorder Risk and Psychological Distress in Adults With Class 3 Obesity GLP-1受体激动剂治疗对3级肥胖成人饮食失调风险和心理困扰的影响

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-10-26 DOI: 10.1002/eat.24575

Sian Maynard, Phillipa Hay, Ritesh Chimoriya, Pamela Acosta Reyes, Kathy Grudzinskas, Nic Kormas, Milan K. Piya

Objective

Eating disorders (ED) and psychological distress are highly prevalent in individuals with Class 3 obesity (BMI ≥ 40 kg/m²). With the increasing use of glucagon-like peptide-1 receptor agonists (GLP1-RA), concerns have emerged about the potential worsening of ED symptoms. This study aimed to compare ED risk and psychological distress in adults with Class 3 obesity: (1) between those already on GLP1-RA and those not and (2) between baseline and 12 months in individuals initiated on GLP1-RA in the program.

Method

This retrospective observational cohort study included adults with Class 3 obesity enrolled in a publicly funded multidisciplinary weight management program in Sydney from January 2018 to June 2024. Participants completed the Eating Disorder Examination-Questionnaire Short (EDE-QS), Kessler Psychological Distress Scale (K10), and Depression, Anxiety and Stress Scale-21 (DASS-21) at baseline and 12-months.

Results

Among 666 participants, 59 (9%) were on GLP1-RA at baseline, with no significant differences in EDE-QS, K10, or DASS-21 scores compared to those not on GLP1-RA. Of 203 participants not on a GLP1-RA at baseline and having 12-month data, 31 (15.3%) initiated GLP1-RA treatment, with the majority on semaglutide 1 mg and a mean duration of use of 7.1 ± 3.7 months. Those initiated on GLP1-RA had a significant reduction in median weight, from 131.0 (118.7–149.6) kg at baseline to 120.0 (109.2–135.3) kg at 12 months, p < 0.001. There were no statistically significant changes in EDE-QS, K10, and DASS-21 scores from baseline to 12 months, and none stopped GLP1-RA due to ED symptoms or psychological distress.

Discussion

This study suggests that GLP1-RAs may not significantly worsen ED risk or psychological distress in adults with Class 3 obesity.

目的：饮食失调（ED）和心理困扰在3级肥胖（BMI≥40 kg/m2）人群中非常普遍。随着胰高血糖素样肽-1受体激动剂（GLP1-RA）的使用越来越多，人们开始关注ED症状的潜在恶化。本研究旨在比较3级肥胖成人的ED风险和心理困扰：(1)已接受GLP1-RA治疗者和未接受GLP1-RA治疗者的ED风险和心理困扰；(2)在项目中开始接受GLP1-RA治疗的个体的基线和12个月之间的ED风险。方法：这项回顾性观察队列研究纳入了2018年1月至2024年6月在悉尼参加公共资助的多学科体重管理项目的3级肥胖成年人。参与者在基线和12个月完成饮食失调检查问卷（ed - qs）、凯斯勒心理困扰量表（K10）和抑郁、焦虑和压力量表-21 （DASS-21）。结果：在666名参与者中，59名（9%）在基线时接受GLP1-RA治疗，与未接受GLP1-RA治疗的患者相比，ed - qs、K10或DASS-21评分无显著差异。203名基线时未服用GLP1-RA且有12个月数据的参与者中，31名（15.3%）开始了GLP1-RA治疗，其中大多数服用了1 mg的semaglutide，平均使用时间为7.1±3.7个月。开始GLP1-RA治疗的患者体重中位数显著降低，从基线时的131.0 (118.7-149.6)kg降至12个月时的120.0 (109.2-135.3)kg。讨论：该研究表明，GLP1-RAs可能不会显著加重3级肥胖成人ED风险或心理困扰。

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引用次数: 0

Maternal Gestational Low-Grade Inflammation and the Risk of Anorexia Nervosa in Daughters 母亲妊娠期低度炎症与女儿神经性厌食症的风险。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-10-24 DOI: 10.1002/eat.24586

Emma Saure, Pyry N. Sipilä, Cynthia M. Bulik, Elina Santti, Heljä-Marja Surcel, Antti Latvala, Anu Raevuori

Objective

Prenatal exposures have been suggested to have a programming effect on neural and metabolic development, which may affect the risk of eating disorders. We investigated the association between prospectively measured maternal gestational high-sensitivity C-reactive protein (hs-CRP), an established inflammatory biomarker, and subsequent risk of AN in daughters.

Method

This nested case–control study with sibling-comparison design used systematic sampling from a register-based cohort including all eating disorder patients in Finland born 1991–2000 and diagnosed in specialized health care. Final sample included 150 full triads of females with severe AN (ICD-10 code F50.0), age- and sex-matched population controls, and biological sister controls (total N = 450).

Results

Mean gestational hs-CRP values were 4.10 mg/L (SD 5.22), 4.83 mg/L (SD 4.88), and 5.53 mg/L (SD 10.36), for individuals with AN, population controls, and sister controls, respectively. Higher hs-CRP was associated with decreased risk for AN when compared to sister controls (adjusted OR 0.68, 95% Cl 0.48–0.97, p = 0.03). Analyzing hs-CRP in tertiles, maternal hs-CRP in the highest tertile (≥ 5.13 mg/L) versus lowest tertile (≤ 1.94 mg/L) was associated with decreased risk for AN compared to sisters (adjusted OR 0.35, 95% Cl 0.15–0.80, p = 0.01), and to all controls combined (adjusted OR 0.52, 95% Cl 0.29–0.93, p = 0.03).

Discussion

We found no evidence that higher gestational CRP would increase the later risk of AN. On the contrary, lower maternal low-grade inflammation early in pregnancy was associated with an increased risk of AN in daughters.

目的：产前暴露已被认为对神经和代谢发育具有编程效应，这可能影响饮食失调的风险。我们研究了前瞻性测量的母体妊娠期高敏c反应蛋白（hs-CRP）（一种已建立的炎症生物标志物）与女儿an的后续风险之间的关系。方法：该巢式病例对照研究采用兄弟姐妹比较设计，采用基于登记的队列系统抽样，包括1991-2000年出生并在专业医疗机构诊断的芬兰所有饮食失调患者。最终样本包括150例严重AN女性患者（ICD-10代码F50.0）、年龄和性别匹配的人群对照和生物姐妹对照（总N = 450）。结果：AN个体、人群对照组和姐妹对照组的妊娠期hs-CRP平均值分别为4.10 mg/L （SD 5.22）、4.83 mg/L （SD 4.88）和5.53 mg/L （SD 10.36）。与姐妹对照组相比，较高的hs-CRP与AN风险降低相关（校正OR 0.68, 95% Cl 0.48-0.97, p = 0.03）。分析三分位数的hs-CRP，与姐妹相比，母亲hs-CRP最高的三分位数（≥5.13 mg/L）与最低的三分位数（≤1.94 mg/L）的AN风险降低相关（校正OR为0.35,95% Cl为0.15-0.80,p = 0.01），与所有对照相比（校正OR为0.52,95% Cl为0.29-0.93,p = 0.03）。讨论：我们没有发现妊娠期CRP升高会增加AN后期风险的证据。相反，妊娠早期较低的母体低度炎症与女儿an的风险增加有关。

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引用次数: 0

Dietary Restraint: Far Too Complex to Dismiss as a Fallacy 饮食限制：太复杂了，不能被视为谬论。

IF 4.3 2区医学 Q1 NUTRITION & DIETETICS

International Journal of Eating Disorders

Pub Date : 2025-10-23 DOI: 10.1002/eat.24582

Marle Alvarenga, César Moraes

In her commentary Dietary Restraint Fallacy, Jansen argues that the theory linking dietary restraint to binge eating and weight gain can be dismissed as a “fallacy.” This conclusion is largely drawn from Grilo and Pittman, who found that rigid restraint was associated with reduced binge frequency and greater weight loss. We contend that dietary restraint remains a profoundly complex and unsettled issue, with implications for weight regain and eating disorder prevention. Importantly, the three Commentaries on Grilo and Pittman were invited simultaneously. Readers encountering only one of them may not realize that these papers were designed to present contrasting viewpoints. In this Commentary, we stress why restraint theory cannot be dismissed wholesale, highlight the need for integration between obesity and eating disorders fields, and emphasize that premature simplifications risk distorting both scientific understanding and clinical practice.

在她的评论《饮食限制谬论》中，詹森认为，将饮食限制与暴饮暴食和体重增加联系起来的理论可以作为“谬论”而被驳回。这一结论主要来自格里洛和皮特曼，他们发现严格的限制与减少暴食频率和更大的体重减轻有关。我们认为，饮食限制仍然是一个非常复杂和未解决的问题，与体重反弹和饮食失调的预防有关。重要的是，三位对格里洛和皮特曼的评论同时被邀请。只遇到其中一个的读者可能没有意识到这些论文的目的是提出不同的观点。在这篇评论中，我们强调了为什么约束理论不能被全盘否定，强调了肥胖和饮食失调领域之间整合的必要性，并强调过早的简化有可能扭曲科学理解和临床实践。

引用次数: 0