Journal of Pain最新文献

P2Y12 signaling in muscle satellite cells contributes to masseter muscle contraction-induced pain

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-07 DOI: 10.1016/j.jpain.2025.105360

Sho Sawada , Suzuro Hitomi , Yoshinori Hayashi , Kenji Yoshikawa , Fumitaka Yagasaki , Hirotaka Shinozuka , Yoshiyuki Yonehara , Yoshiyuki Tsuboi , Koichi Iwata , Masamichi Shinoda

The mechanism behind masseter muscle pain, a major symptom of temporomandibular disorder (TMD), has remained poorly understood. Previous report indicates that adenosine triphosphate (ATP) is involved in the masseter muscle pain development, but the role of its hydrolysis product, adenosine diphosphate (ADP), remains uncertain. Consequently, this study aimed to elucidate the ADP role derived from the sustained masseter muscle contraction in the masseter muscle pain development. The right masseter muscle was electrically stimulated daily by placing electrodes on the muscle fascia, inducing strong contraction and mechanical allodynia. This led to an increment of the ATP release from the masseter muscle and a consequent increase in ADP produced by the hydrolysis of ATP. The mechanical allodynia was suppressed by intramuscular P2Y₁₂ receptor antagonism and tumor necrosis factor alpha (TNF-α) inhibition. Additionally, muscle satellite cells expressed P2Y₁₂ receptors, and the increase in amount of TNF-α released from these cells due to sustained contraction of the masseter muscle was suppressed by intramuscular P2Y₁₂ receptor antagonism. These findings suggest that sustained masseter muscle contraction increases ADP levels within the muscle; this ADP, produced by the hydrolysis of ATP, promotes the release of TNF-α via P2Y₁₂ receptors. The TNF-α signaling is likely to enhance the excitability of primary neurons projecting to the masseter muscle, thereby inducing masseter muscle pain. Therefore, it is plausible that TNF-α-induced nociceptive neuronal hyperexcitability through enhanced ADP signaling via P2Y₁₂ receptors in satellite cells could be a candidate for therapeutic intervention for masseter muscle pain, a major symptom of TMD.

Perspective

Sustained masseter muscle contraction in rats induced mechanical allodynia and increased the amount of ADP within the muscle. Muscle satellite cells expressed P2Y₁₂ receptors, and ADP-P2Y₁₂ signaling increased the TNF-α release from these cells. TNF-α signaling enhanced the primary neuronal excitability, inducing masseter muscle pain.

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引用次数: 0

Attitudes toward patient engagement in clinical pain research: Insights from individuals with chronic pain in the United States.

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-07 DOI: 10.1016/j.jpain.2025.105358

Katherine J Holzer, Haley E Bernstein, Christin Veasley, Simon Haroutounian, Dagmar Amtmann, Aderonke Bamgbose Pederson, Bryce B Reeve, Dennis C Turk, Robert H Dworkin, Dale J Langford

The value of engaging people with lived experience into chronic pain research is becoming increasingly recognized, yet the perspectives of individuals with chronic pain who have not previously participated in research are underexplored. This study aims to fill this gap by assessing the attitudes, preferences, and barriers related to patient engagement among adults living with chronic pain in the United States (US). An online survey was developed in collaboration with an advisory board and community engagement studio and distributed through Qualtrics panels from December 2023-January 2024. Quotas for age, gender, and race were employed to reach a representative sample for each of these variables based on the 2020 US census.^1,2 Of the 505 participants, 267 reported chronic low back pain (53%) and 144 had headaches or migraines (22%). A majority (65%-79%) were familiar with medical research, and 64% (n = 327) expressed interest in engaging as patient partners. Key facilitators for engagement included the desire to help others and learn about their condition, while compensation was also an important motivator. Barriers were time constraints, lack of payment, and worry about privacy. Younger participants (Chi-square p = 0.04) and those with higher education (Chi-square p = 0.01) were more likely to express interest in research partnerships. Strategies to enhance patient engagement should focus on reducing barriers and providing clear, meaningful opportunities for engagement, potentially increasing both recruitment and retention in chronic pain research. Future research should explore these dynamics further and consider international perspectives to develop comprehensive patient engagement strategies. PERSPECTIVE: This study surveys over 500 individuals with chronic pain to understand their attitudes towards engagement in clinical pain research. It identifies key facilitators and barriers, such as time constraints and low compensation, and aims to refine strategies to enhance patient partner engagement and representation in clinical pain research.

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引用次数: 0

Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light.

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-06 DOI: 10.1016/j.jpain.2025.105359

Matthew R Sapio, Diana M King, Dragan Maric, Samay R Shah, Thomas L Talbot, Allison P Manalo, Pranavi Nara, Wenting Ma, Andre Ghetti, Christopher E Ramsden, Michael J Iadarola, Andrew J Mannes

Background autofluorescence is enhanced in human tissue relative to small animals and presents a barrier to fully realizing the potential of novel multiplex methods in human studies. In particular, lipofuscin (LF) is an interfering pigment in multiplex fluorescence assays. Lipofuscin (LF) is a highly cross-linked aggregate of oxidized lipids, proteins, sugars, and metal ions that accumulates in lysosomes with age, and is strongly fluorescent across wavelengths that interfere with signals from common fluorophores. This is particularly apparent in dorsal root ganglion (DRG), where the LF deposits occupy up to 80% of the visible neuronal cytoplasm, affecting ~45% of neurons in a typical section. This report describes a straightforward, scalable, pre-staining, white-light photobleaching method that near-totally reduces LF autofluorescence, and improves signal detection across the color spectrum without negatively impacting the multiplex fluorescence detection assay. It is effective for peripheral and central nervous system structures as well as pathological tissue such as Alzheimer's disease brain, which contains high levels of autofluorescent interference. This demonstrates the broad applicability to improving signal detection in human disease states to enable translational investigations in humans. This low-cost procedure can be rapidly implemented into existing research programs to increase the accessibility of high-plex fluorescent microscopy methodologies to enable direct-in-human research. PERSPECTIVE: White light photobleaching of lipofuscin before multiplex fluorescent in situ hybridization allows for rapid, near-total quenching of autofluorescence in healthy and diseased human nervous system tissue. Given the importance of direct-in-human investigations for validating translational studies and ensuring medical relevance, this simple yet powerful advance enables future anatomical investigations.

{"title":"Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light.","authors":"Matthew R Sapio, Diana M King, Dragan Maric, Samay R Shah, Thomas L Talbot, Allison P Manalo, Pranavi Nara, Wenting Ma, Andre Ghetti, Christopher E Ramsden, Michael J Iadarola, Andrew J Mannes","doi":"10.1016/j.jpain.2025.105359","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105359","url":null,"abstract":"<p><p>Background autofluorescence is enhanced in human tissue relative to small animals and presents a barrier to fully realizing the potential of novel multiplex methods in human studies. In particular, lipofuscin (LF) is an interfering pigment in multiplex fluorescence assays. Lipofuscin (LF) is a highly cross-linked aggregate of oxidized lipids, proteins, sugars, and metal ions that accumulates in lysosomes with age, and is strongly fluorescent across wavelengths that interfere with signals from common fluorophores. This is particularly apparent in dorsal root ganglion (DRG), where the LF deposits occupy up to 80% of the visible neuronal cytoplasm, affecting ~45% of neurons in a typical section. This report describes a straightforward, scalable, pre-staining, white-light photobleaching method that near-totally reduces LF autofluorescence, and improves signal detection across the color spectrum without negatively impacting the multiplex fluorescence detection assay. It is effective for peripheral and central nervous system structures as well as pathological tissue such as Alzheimer's disease brain, which contains high levels of autofluorescent interference. This demonstrates the broad applicability to improving signal detection in human disease states to enable translational investigations in humans. This low-cost procedure can be rapidly implemented into existing research programs to increase the accessibility of high-plex fluorescent microscopy methodologies to enable direct-in-human research. PERSPECTIVE: White light photobleaching of lipofuscin before multiplex fluorescent in situ hybridization allows for rapid, near-total quenching of autofluorescence in healthy and diseased human nervous system tissue. Given the importance of direct-in-human investigations for validating translational studies and ensuring medical relevance, this simple yet powerful advance enables future anatomical investigations.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105359"},"PeriodicalIF":4.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain Sensitivity Questionnaire in Endometriosis. 子宫内膜异位症疼痛敏感性问卷调查

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-04 DOI: 10.1016/j.jpain.2025.105357

Avonae J Gentles, Sarah Wong, Natasha L Orr, Heather Noga, Catherine Allaire, Christina Williams, Mohamed A Bedaiwy, Caroline Lee, John Kramer, Paul J Yong

There is increasing recognition that nociplastic pain and central sensitization may play a role in endometriosis-associated pain. The Pain Sensitivity Questionnaire Minor (PSQ-M) evaluates subjective widespread pain sensitivity, and is linked to pain outcomes in chronic pain populations. However, evidence connecting the PSQ-M to central sensitization in endometriosis is limited. Using the Central Sensitization Inventory (CSI) as a comparison, this study compared the PSQ-M as a clinical proxy for central sensitization in endometriosis individuals. Data collected from 983 endometriosis participants (mean age of 34 years), between January 2020 and December 2022, were analyzed from a prospective registry. A significant but weak positive correlation was observed between PSQ-M and CSI scores (r=0.099, p<0.05). A significant but weak correlation was found between the number of central sensitivity syndromes and pelvic pain-related comorbidities with the PSQ-M (r=0.093, p<0.05), compared to a stronger correlation with the CSI (r=0.687, p<0.05). PSQ-M scores were not significantly associated with baseline (r=0.013, p=0.68) or post-operative (r=-0.046, p=0.57) quality-of-life. There was no change in the PSQ-M and a small change in CSI after endometriosis surgery, suggesting that surgical treatment of endometriosis does not directly address central sensitization. In conclusion, the PSQ-M may not be the optimal clinical proxy for central sensitization in endometriosis. PERSPECTIVE: This study evaluates the Pain Sensitivity Questionnaire - Minor (PSQ-M) as a proxy for central sensitization in endometriosis. The PSQ-M showed weak correlations with central sensitivity syndromes and pain scores and was not associated with post-surgical quality-of-life, suggesting it may not be the optimal tool for assessing central sensitization in endometriosis.

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引用次数: 0

Contemporary media campaigns for musculoskeletal pain: A systematic review and meta-analysis with social marketing benchmarking 针对肌肉骨骼疼痛的当代媒体宣传：以社会营销为基准的系统回顾和荟萃分析。

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-01 DOI: 10.1016/j.jpain.2024.104739

Felicity A. Braithwaite Dr , Sameer Deshpande , Rachelle Buchbinder , Liz Dennett , Craig Richard St. Jean , Brandon Krebs , Douglas P. Gross

Musculoskeletal pain is a global public health problem. Social marketing aims to increase adoption of desired behaviours in target audiences and may uncover new strategies to improve uptake of helpful pain-related behaviours at the population-level. We systematically evaluated effects of contemporary mass media campaigns targeting musculoskeletal pain and used social marketing benchmarking to explore strategies associated with campaign success. Published evaluations of campaigns involving an online/digital component and a comparator/control condition were eligible. The primary outcome was population beliefs; secondary outcomes were healthcare provider beliefs, behavioural (e.g., healthcare-related, work-related), clinical (e.g., pain), and economic outcomes. Decision-rules and meta-analyses (random-effects models) were used to synthesise findings. Eight databases and grey literature were searched from inception to May 2024. Thirteen eligible publications evaluated eight campaigns (N = 5 back pain, N = 2 rheumatic pain; N = 1 work-related pain) from eight Western/high-income countries. All evaluations reported historical control data (interrupted time-series/before-and-after designs); three also compared selected outcomes to an unexposed geographical region (quasi-experimental designs). Risk of bias was weak-moderate for all evaluations. Population beliefs improved from baseline vs. final follow-up (1.5–10yrs) for items related to ‘staying active’ [RR = 1.38 (95%CI: 1.14–1.67), N = 4 campaigns, n = 12,568 participants] and ‘rest’ [RR = 1.35 (95%CI: 1.14–1.60), N = 5 campaigns, n = 14,571 participants] for pain management, however, certainty of evidence was very low. Other outcomes were not pooled due to heterogeneity, and evidence was mixed. Greater numbers of social marketing benchmarks were associated with successful campaign outcomes. Future campaigns should implement social marketing strategies beyond education alone, including behaviour change support, to facilitate adoption of desired pain-related behaviours.

Registration

PROSPERO registration number: CRD42023400456; Open Science Framework (detailed Social Marketing Benchmarking analysis plan): https://osf.io/npyck/.

Perspective

We systematically evaluated contemporary mass media campaigns targeting musculoskeletal pain. Promising improvements in population beliefs about pain supports continued investment into campaigns. Our review provides critical new information including social marketing strategies to ensure future campaign efforts shift population-level pain-related behaviours, towards reducing the societal burden of pain.

肌肉骨骼疼痛是一个全球性的公共健康问题。社会营销的目的是提高目标受众对理想行为的采纳，并可能发现新的策略来提高人群对与疼痛相关的有益行为的采纳。我们系统地评估了针对肌肉骨骼疼痛的当代大众媒体活动的效果，并使用社会营销基准来探索与活动成功相关的策略。已发表的对涉及在线/数字内容和参照/对照条件的宣传活动的评估符合条件。主要结果是人群的信念；次要结果是医疗服务提供者的信念、行为（如与医疗相关、与工作相关）、临床（如疼痛）和经济结果。采用决策规则和荟萃分析（随机效应模型）来综合研究结果。检索了从开始到 2024 年 5 月的八个数据库和灰色文献。13 篇符合条件的出版物评估了来自 8 个西方/高收入国家的 8 项活动（N=5 项背痛、N=2 项风湿痛；N=1 项工作相关疼痛）。所有评估都报告了历史对照数据（间断时间序列/前后设计）；三项评估还将选定结果与未受影响的地理区域进行了比较（准实验设计）。所有评估的偏倚风险均为弱-中等。从基线到最终随访（1.5-10 年），与 "保持活跃"[RR=1.38（95%CI：1.14-1.67），N=4 项活动，n=12,568 名参与者] 和 "休息"[RR=1.35（95%CI：1.14-1.60），N=5 项活动，n=14,571 名参与者] 有关的疼痛管理项目的人群信念有所改善，但证据的确定性很低。由于存在异质性，其他结果未进行汇总，证据也参差不齐。更多的社会营销基准与活动的成功结果相关。未来的宣传活动应实施社会营销策略，而不仅仅是教育，包括行为改变支持，以促进人们采取所期望的疼痛相关行为。注册：PROSPERO 注册号：CRD42023400456；开放科学框架（详细的社会营销基准分析计划）：https://osf.io/npyck/ 观点：我们系统地评估了当代针对肌肉骨骼疼痛的大众媒体宣传活动。人们对疼痛的看法有望得到改善，这支持了我们对宣传活动的持续投资。我们的综述提供了重要的新信息，包括社会营销策略，以确保未来的宣传活动能改变人们与疼痛相关的行为，从而减轻疼痛带来的社会负担。

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引用次数: 0

Enhancing the trustworthiness of pain research: A call to action. 提高疼痛研究的可信度：行动呼吁。

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-01 DOI: 10.1016/j.jpain.2024.104736

The ENTRUST-PE Network, Neil E. O’Connell , Joletta Belton , Geert Crombez , Christopher Eccleston , Emma Fisher , Michael C. Ferraro , Anna Hood , Francis Keefe , Roger Knaggs , Emma Norris , Tonya M. Palermo , Gisèle Pickering , Esther Pogatzki-Zahn , Andrew SC Rice , Georgia Richards , Daniel Segelcke , Keith M. Smart , Nadia Soliman , Gavin Stewart , Amanda C.de C. Williams

The personal, social and economic burden of chronic pain is enormous. Tremendous research efforts are being directed toward understanding, preventing, and managing chronic pain. Yet patients with chronic pain, clinicians and the public are sometimes poorly served by an evidence architecture that contains multiple structural weaknesses. These include incomplete research governance, a lack of diversity and inclusivity, inadequate stakeholder engagement, poor methodological rigour and incomplete reporting, a lack of data accessibility and transparency, and a failure to communicate findings with appropriate balance. These issues span pre-clinical research, clinical trials and systematic reviews and impact the development of clinical guidance and practice. Research misconduct and inauthentic data present a further critical risk. Combined, they increase uncertainty in this highly challenging area of study and practice, drive the provision of low value care, increase costs and impede the discovery of more effective solutions.

In this focus article, we explore how we can increase trust in pain science, by examining critical challenges using contemporary examples, and describe a novel integrated conceptual framework for enhancing the trustworthiness of pain science. We end with a call for collective action to address this critical issue.

Perspective

Multiple challenges can adversely impact the trustworthiness of pain research and health research more broadly. We present ENTRUST-PE, a novel, integrated framework for more trustworthy pain research with recommendations for all stakeholders in the research ecosystem, and make a call to action to the pain research community.

慢性疼痛给个人、社会和经济造成了巨大负担。为了了解、预防和控制慢性疼痛，人们正在进行大量的研究工作。然而，慢性疼痛患者、临床医生和公众有时并不能从包含多种结构性缺陷的证据架构中得到很好的服务。这些弱点包括：研究管理不完善、缺乏多样性和包容性、利益相关者参与不足、研究方法不够严谨和报告不完整、缺乏数据可获取性和透明度，以及未能以适当的平衡方式交流研究结果。这些问题涉及临床前研究、临床试验和系统性综述，影响着临床指南和实践的制定。研究不端行为和不真实的数据带来了更大的风险。这些问题加在一起，增加了这一极具挑战性的研究和实践领域的不确定性，导致提供低价值的医疗服务、增加成本并阻碍发现更有效的解决方案。在这篇重点文章中，我们通过使用当代实例研究关键挑战，探讨了如何提高疼痛科学的可信度，并描述了一个新颖的综合概念框架，以提高疼痛科学的可信度。最后，我们呼吁采取集体行动解决这一关键问题。观点：多重挑战会对疼痛研究和更广泛的健康研究的可信度产生不利影响。我们介绍了 ENTRUST-PE，这是一个新颖的综合框架，旨在提高疼痛研究的可信度，并为研究生态系统中的所有利益相关者提出了建议，同时呼吁疼痛研究界采取行动。

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引用次数: 0

Quantitative sensory testing and exercise-induced hypoalgesia protocols in low back pain: A scoping review 腰背痛的定量感觉测试和运动诱导低镇痛方案：范围综述。

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-01 DOI: 10.1016/j.jpain.2024.104725

Lee-Ran Goodman MSc, Ronessa Dass MSc, Eden Daniel MSc, Shirin Modarresi PT, PhD, Lisa Carlesso PT, PhD, Ada Tang PT, PhD, Luciana Macedo PT, PhD

A significant driver of pain in individuals with low back pain (LBP) is alterations to endogenous pain modulation (EPM). EPM can be measured using quantitative sensory testing (QST), however; there are inconsistencies in the way QST has been implemented across the low back pain literature. The objective of this scoping review was to summarize protocols used to assess EPM using QST (pain pressure threshold (PPT), temporal summation (TS), conditioned pain modulation (CPM)) or exercise-induced hypoalgesia (EIH) in LBP. Databases Medline, Embase, CINAHL and AMED were searched on June 15, 2023, for articles that used QST or EIH protocols in LBP populations. Data was extracted on participants, study design, setting and details on QST and EIH protocols. Of the 221 studies included in the review, 196 used PPT, 62 used TS and 60 used CPM; only 5 studies investigated EIH. For all QST, there was high variability in the type of equipment, timing, trials, and testing location with many studies not reporting this information. There were 4 testing modalities used for TS, and 7 different test stimuli, and 3 different conditioning stimuli used across the studies for CPM. For CPM and EIH, PPT was the most common testing modality. There were 4 types of exercises used across the 5 EIH studies. This scoping review provides a summary of QST and EIH protocols in LBP that may be used as a guide for assessment in future studies. These results demonstrate a need for the development of standardized protocols and reporting guidelines.

Perspective

This article presents a summary of measures used to assess EPM in LBP. The results show the wide variability of protocols used in the literature. Future research should focus on creating standardized protocols, reporting guidelines and providing more guidance for researchers in selecting appropriate tests for their research questions.

腰背痛（LBP）患者疼痛的一个重要驱动因素是内源性疼痛调节（EPM）的改变。EPM 可以通过定量感觉测试 (QST) 进行测量，但是，腰背痛文献中实施 QST 的方式并不一致。本范围综述旨在总结使用 QST（疼痛压力阈值 (PPT)、时间总和 (TS)、条件性疼痛调制 (CPM)）或运动诱导低痛 (EIH) 评估腰背痛 EPM 的方案。2023 年 6 月 15 日，在 Medline、Embase、CINAHL 和 AMED 等数据库中检索了在枸杞痛人群中使用 QST 或 EIH 方案的文章。研究人员提取了有关参与者、研究设计、环境以及 QST 和 EIH 方案详情的数据。在纳入综述的 221 项研究中，196 项使用了 PPT，62 项使用了 TS，60 项使用了 CPM；只有 5 项研究调查了 EIH。对于所有 QST，在设备类型、时间、试验和测试地点方面存在很大差异，许多研究没有报告这些信息。在 TS 测试中使用了 4 种测试模式，在 CPM 测试中使用了 7 种不同的测试刺激和 3 种不同的调节刺激。对于 CPM 和 EIH，PPT 是最常见的测试模式。在 5 项 EIH 研究中使用了 4 种类型的练习。本范围综述总结了枸杞多糖症的 QST 和 EIH 方案，可作为未来研究的评估指南。这些结果表明有必要制定标准化方案和报告指南。观点：本文总结了用于评估枸杞多糖症中 EPM 的措施。结果显示，文献中使用的方案差异很大。未来的研究应侧重于制定标准化方案和报告指南，并为研究人员提供更多指导，帮助他们针对研究问题选择合适的测试。

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引用次数: 0

Widespread and prolonged pain may reduce brain clearance capacity only via sleep impairment: Evidence from participants with knee pain

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-01 DOI: 10.1016/j.jpain.2025.105356

Pedro A. Valdes-Hernandez , Soamy Montesino-Goicolea , Chavier Laffitte Nodarse , Alisa J. Johnson , Roger B. Fillingim , Yenisel Cruz-Almeida

The brain is key in the pain-sleep relationship, and sleep is needed for glymphatic clearance. However, no studies have examined how pain relates to the glymphatic system (GS). Characterizing the GS alongside sleep quality in well-characterized pain samples is essential for advancing this understanding. Non-invasive MRI techniques, such as Diffusion Tensor Imaging-Analysis aLong the Perivascular Space (DTI-ALPS), are particularly valuable as they are approved for humans. Although the relationship between the DTI-ALPS index and the GS is primarily deductive, the index may be a proxy for waste clearance capacity in deep white matter. Its sensitivity to interstitial space changes—known to be modulated by norepinephrine—offers a unique opportunity to investigate how sleep impairment and chronic pain regulation affect specific components of brain waste clearance. We thus fitted two longitudinal models linking pain, sleep quality and the DTI-ALPS index. We hypothesized that variations in pain characteristics would predict DTI-ALPS index changes, either directly or mediated by sleep quality changes. Alternatively, we hypothesized that variations in sleep quality would predict changes in pain characteristics via DTI-ALPS index modifications. Knee pain participants (n=87) completed an MRI and self-reported measures of pain and sleep impairment at baseline and two years later. We only found evidence supporting that more widespread and longer pain at baseline significantly influenced decreases in the DTI-ALPS index in the left hemisphere through increased sleep impairment two years later (p=0.039, corrected).

Perspective

Findings highlight the need for research on the relationship between pain and sleep quality and its implications for brain health.

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引用次数: 0

Chronic pain-induced functional and structural alterations in the brain: A multi-modal meta-analysis 慢性疼痛诱发的大脑功能和结构改变：多模态荟萃分析。

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-01 DOI: 10.1016/j.jpain.2024.104740

Xinglin Zeng PhD , Yinghao Sun BSc , Zhao Zhiying PhD , Lin Hua PhD , Zhen Yuan PhD

Chronic pain is a debilitating condition associated with brain alterations. However, the variability in neuroimaging results across modalities necessitates a comprehensive multi-modal meta-analysis for a cohesive understanding. This study aims to elucidate brain alterations in chronic pain patients using a multi-modal meta-analysis approach encompassing structural, resting-state functional connectivity, and pain processing paradigms in functional magnetic resonance imaging. A systematic literature search was conducted across PubMed, OVID Embase, OVID Medline, and Web of Science, encompassing studies published up to May 2022, to identify relevant research articles on chronic pain and MRI techniques in three modalities. Inclusion criteria encompassed experiments reporting three modality brain alterations in chronic pain patients, with sufficient statistical thresholds and enough sample size. We conducted voxel-wise meta-analyses using seed-based d mapping to identify significant alterations in each modality. Additionally, conjunction analyses were executed to identify common alterations across these modalities. Ultimately, 47 structure studies, 37 resting state functional connectivity studies, and 41 pain-processing studies were selected for formal analysis. Chronic pain patients displayed notable structural and functional alterations in the insular cortex, characterized by reduced gray matter, disruptions in functional connectivity with the frontoparietal network, and enhanced activation during painful stimuli processing. Distinct activation patterns were observed in the left and right insular cortex for pain stimulus processing versus anticipation. Furthermore, the superior temporal gyrus and superior frontal gyrus exhibited joint alterations across modalities. This multi-modal meta-analysis reveals consistent brain alterations in chronic pain patients, shedding light on the complex interplay between structural and functional changes.

Perspective

This multi-modal meta-analysis integrates findings from structural, resting-state functional connectivity, and pain processing paradigms in fMRI, revealing consistent brain alterations in chronic pain patients. Notable brain changes highlight the intricate interplay between structural and functional brain changes, advancing our understanding of chronic pain’s neural underpinnings.

慢性疼痛是一种使人衰弱的疾病，与大脑的改变有关。然而，不同模式的神经成像结果存在差异，因此有必要进行全面的多模式荟萃分析，以获得一致的认识。本研究旨在采用多模态荟萃分析方法阐明慢性疼痛患者的大脑改变，包括功能磁共振成像中的结构、静息态功能连接和疼痛处理范式。我们在PubMed、OVID Embase、OVID Medline和Web of Science上进行了系统的文献检索，涵盖了截至2022年5月30日发表的研究，以确定关于慢性疼痛和三种模式的核磁共振成像技术的相关研究文章。纳入标准包括报告慢性疼痛患者三种模式脑部改变的实验，并具有足够的统计阈值和样本量。我们使用基于种子的 d 映射进行了体素荟萃分析，以确定每种模式的显著改变。此外，我们还进行了联合分析，以确定这些模式的共同改变。最终，47 项结构研究、37 项静息状态功能连接研究和 41 项疼痛处理研究被选中进行正式分析。慢性疼痛患者的岛叶皮质显示出明显的结构和功能改变，其特点是灰质减少、与额顶网络的功能连接中断以及在处理疼痛刺激时激活增强。在左侧和右侧岛叶皮层中观察到了不同的激活模式，即疼痛刺激处理与预期相比。此外，颞上回和额叶上回也表现出了跨模态的联合改变。这项多模态荟萃分析揭示了慢性疼痛患者大脑的一致变化，阐明了结构和功能变化之间复杂的相互作用。观点：这项多模态荟萃分析整合了fMRI结构、静息状态功能连接和疼痛处理范式的研究结果，揭示了慢性疼痛患者大脑的一致改变。显著的大脑变化突显了大脑结构和功能变化之间错综复杂的相互作用，加深了我们对慢性疼痛神经基础的理解。

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引用次数: 0

Language errors in pain medicine: An umbrella review 疼痛医学中的语言错误：总体回顾。

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Pain

Pub Date : 2025-03-01 DOI: 10.1016/j.jpain.2024.104738

Bastien Léo Béraud , André Meichtry , Kay-Uwe Hanusch , Roger Hilfiker

Errors in language are common in pain medicine, but the extent of such errors has not been systematically measured. This pre-registered umbrella review explored Embase, PubMed, Medline and CINAHL and seeks to quantify the prevalence of errors in language in review articles since the last IASP definition revision. To be eligible, studies must have met the following criteria: 1) Primary aim was stated as to provide neurophysiological explanations of nociception and/or pain in humans in context of a pathology/condition; 2) Any type of review article; 3) Written in English; 4) Published in a peer-reviewed journal. Studies were excluded if they met any of the following criteria: 5) Published prior to the last revision of the IASP definition; 6) Published after May 2023; 7) Published in a predatory journal. Out of 5470 articles screened, 48 review articles met the inclusion criteria. All articles contained at least one error in language, there were no differences in the proportions of errors in language in review articles between years of publication, and various predictors were mostly not associated with a higher or lower number of errors in language counts in articles. Our findings reveal the need for heightened awareness among researchers, clinicians, journals and editorial boards regarding the prevalence and impact of these errors. Given our findings and their limitations, further research should focus on examining the contextual influence of misnomer usage and replication of these results.

Perspective

This umbrella review explored the main biomedical databases to see how many review articles contained language errors. Our findings underscore the imperative for prompt action in regulating pain medicine terminology.

Pre-registration

This umbrella review was pre-registered on OSF registries (https://doi.org/10.17605/osf.io/kau8m).

Online material

https://osf.io/kdweg/

语言错误在疼痛医学中很常见，但此类错误的程度尚未得到系统测量。这篇预先注册的总括性综述探讨了 Embase、PubMed、Medline 和 CINAHL，旨在量化自上次 IASP 定义修订以来综述文章中语言错误的普遍程度。符合条件的研究必须满足以下标准：1）主要目的是在病理/条件的背景下对人类的痛觉和/或疼痛提供神经生理学解释；2）任何类型的综述文章；3）用英语撰写；4）发表在同行评审期刊上。符合以下任何一项标准的研究均被排除在外：5）在上次修订 IASP 定义之前发表；6）在 2023 年 5 月之后发表；7）发表在掠夺性期刊上。在筛选出的 5470 篇文章中，有 48 篇综述文章符合纳入标准。所有文章都包含至少一处语言错误，不同出版年份的评论文章中语言错误的比例没有差异，各种预测因素大多与文章中语言错误数量的高低无关。我们的研究结果表明，研究人员、临床医生、期刊和编辑委员会需要提高对这些错误的普遍性和影响的认识。鉴于我们的研究结果及其局限性，进一步的研究应侧重于检查错误用语使用的环境影响并复制这些结果。综述：这篇综述探讨了主要的生物医学数据库，以了解有多少综述文章包含语言错误。我们的研究结果表明，必须立即采取行动规范疼痛医学术语。预先登记：本综述已在 OSF 登记处预先登记 (https://doi.org/10.17605/osf.io/kau8m)。在线资料：https://osf.io/kdweg/。

{"title":"Language errors in pain medicine: An umbrella review","authors":"Bastien Léo Béraud , André Meichtry , Kay-Uwe Hanusch , Roger Hilfiker","doi":"10.1016/j.jpain.2024.104738","DOIUrl":"10.1016/j.jpain.2024.104738","url":null,"abstract":"<div><div>Errors in language are common in pain medicine, but the extent of such errors has not been systematically measured. This pre-registered umbrella review explored Embase, PubMed, Medline and CINAHL and seeks to quantify the prevalence of errors in language in review articles since the last IASP definition revision. To be eligible, studies must have met the following criteria: 1) Primary aim was stated as to provide neurophysiological explanations of nociception and/or pain in humans in context of a pathology/condition; 2) Any type of review article; 3) Written in English; 4) Published in a peer-reviewed journal. Studies were excluded if they met any of the following criteria: 5) Published prior to the last revision of the IASP definition; 6) Published after May 2023; 7) Published in a predatory journal. Out of 5470 articles screened, 48 review articles met the inclusion criteria. All articles contained at least one error in language, there were no differences in the proportions of errors in language in review articles between years of publication, and various predictors were mostly not associated with a higher or lower number of errors in language counts in articles. Our findings reveal the need for heightened awareness among researchers, clinicians, journals and editorial boards regarding the prevalence and impact of these errors. Given our findings and their limitations, further research should focus on examining the contextual influence of misnomer usage and replication of these results.</div></div><div><h3>Perspective</h3><div>This umbrella review explored the main biomedical databases to see how many review articles contained language errors. Our findings underscore the imperative for prompt action in regulating pain medicine terminology.</div></div><div><h3>Pre-registration</h3><div>This umbrella review was pre-registered on OSF registries (https://doi.org/10.17605/osf.io/kau8m).</div></div><div><h3>Online material</h3><div><span><span>https://osf.io/kdweg</span><svg><path></path></svg></span>/</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104738"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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