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Reply to Letter to Editor by Bordoni Bruno, regarding Pain severity and depressive symptoms in endometriosis patients: Mediation of negative body awareness and interoceptive self-regulation 回复Bordoni Bruno致编辑的信,关于子宫内膜异位症患者的疼痛严重程度和抑郁症状:负性身体意识和内感受性自我调节的调解。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.jpain.2024.104755
Caterina Grano
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引用次数: 0
Corrigendum to “Mobile app use among persons with fibromyalgia: a cross-sectional survey” [J Pain, Volume 25, Issue 8, August 2024, 104515] 纤维肌痛患者使用移动应用程序情况:横断面调查》[《疼痛杂志》,第 25 卷,第 8 期,2024 年 8 月,104515]的更正。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.jpain.2024.104708
Jiaxin An , Wei Fan , Anant Mittal , Yan Zhang , Annie T. Chen
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引用次数: 0
Management of Central Poststroke Pain: Systematic Review and Meta-analysis 中风后中枢性疼痛的治疗:系统综述和元分析。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.jpain.2024.104666
Arnas Tamasauskas , Barbara Silva-Passadouro , Nicholas Fallon , Bernhard Frank , Svajune Laurinaviciute , Simon Keller , Andrew Marshall
Central poststroke pain (CPSP) is a neuropathic pain condition prevalent in 8 to 35% of stroke patients. This systematic review and meta-analysis aimed to provide insight into the effectiveness of available pharmacological, physical, psychological, and neuromodulation interventions in reducing pain in CPSP patients (PROSPERO Registration: CRD42022371835). Secondary outcomes included mood, sleep, global impression of change, and physical responses. Data extraction included participant demographics, stroke etiology, pain characteristics, pain reduction scores, and secondary outcome metrics. Forty-two original studies were included, with a total of 1,451 participants. No studies providing psychological therapy to CPSP patients were identified. Twelve studies met requirements for a random-effects meta-analyses that found pharmacological therapy to have a small effect on mean pain score (SMD = −.36, 96.0% confidence interval [−.68, −.03]), physical interventions did not show a significant effect (SMD = −.55 [−1.28, .18]), and neuromodulation treatments had a moderate effect (SMD = −.64 [−1.08, −.19]). Fourteen studies were included in proportional meta-analysis with pharmacological studies having a moderate effect (58.3% mean pain reduction [−36.51, −80.15]) and neuromodulation studies a small effect (31.1% mean pain reduction [−43.45, −18.76]). Sixteen studies were included in the narrative review, the findings from which largely supported meta-analysis results. Duloxetine, amitriptyline, and repetitive transcranial magnetic stimulation had the most robust evidence for their effectiveness in alleviating CPSP-induced pain. Further multicenter placebo-controlled research is needed to ascertain the effectiveness of physical therapies, such as acupuncture and virtual reality, and invasive and noninvasive neuromodulation treatments.

Perspective

This article presents a top-down and bottom-up overview of evidence for the effectiveness of different pharmacological, physical, and neuromodulation treatments of CPSP. This review could provide clinicians with a comprehensive understanding of the effectiveness and tolerability of different treatment types.
中枢性卒中后疼痛(CPSP)是一种神经病理性疼痛,在 8% 至 35% 的卒中患者中普遍存在。本系统综述和荟萃分析旨在深入探讨现有的药物、物理、心理和神经调节干预措施在减轻 CPSP 患者疼痛方面的有效性(PROSPERO 注册:CRD42022371835)。次要结果包括情绪、睡眠、总体变化印象和身体反应。数据提取包括参与者人口统计学、中风病因学、疼痛特征、疼痛减轻评分和次要结果指标。共纳入 42 项原创研究,共有 1451 名参与者。未发现为 CPSP 患者提供心理治疗的研究。12项研究符合随机效应荟萃分析的要求,发现药物治疗对平均疼痛评分的影响较小(SMD = -.36,96.0% 置信区间 [-.68, -.03]),物理干预未显示出显著效果(SMD = -.55 [-1.28, .18]),神经调控治疗效果一般(SMD = -.64 [-1.08, -.19])。14项研究被纳入比例荟萃分析,其中药物治疗具有中等效果(平均疼痛减轻58.3% [-36.51,-80.15]),神经调节治疗效果较小(平均疼痛减轻31.1% [-43.45,-18.76])。16项研究被纳入叙述性综述,研究结果在很大程度上支持荟萃分析结果。度洛西汀、阿米替林和重复经颅磁刺激在缓解 CPSP 引起的疼痛方面具有最有力的证据。需要进一步开展多中心安慰剂对照研究,以确定针灸和虚拟现实等物理疗法以及侵入性和非侵入性神经调控疗法的有效性。观点:本文自上而下和自下而上地综述了不同药物、物理和神经调控治疗 CPSP 的有效性证据。该综述可帮助临床医生全面了解不同治疗方法的有效性和耐受性。
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引用次数: 0
Letter to Editor: Pelvic floor and diaphragm 致编辑的信:盆底和横膈膜。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.jpain.2024.104731
Bruno Bordoni
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引用次数: 0
Seeing your child in pain: Parent empathy in the context of their child’s chronic pain 看到你的孩子在痛苦中:在孩子慢性疼痛的背景下父母的同理心。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-12-31 DOI: 10.1016/j.jpain.2024.104771
Inge Timmers , Lauren E. Harrison , Laura E. Simons
Observing your child in pain is inherently distressing. In the context of chronic pain, caregiver responses can powerfully impact child pain-related functioning. The Parent Empathy in the Context of Pain model postulates that parent empathic distress may hinder adaptive responses to child pain, thus playing a key role in the link between parent responses and child functioning. Here, we examined how parent empathy is related to parent and child pain-related constructs within the Parent Empathy in the Context of Pain model, using an adapted Empathy for Pain Scale (EPS) for use in parents (P-EPS). Data were collected from 190 parents of youth with chronic pain (170 mothers; children aged 8–18y) and their children. Structural equation modeling (SEM) showed support for the theoretical model. Parent pain-related beliefs were associated with behavioral responses via affective responses of empathy for pain (affective distress) and emotion regulation (emotional suppression), which in turn were associated with child pain-related functioning. Moreover, higher levels of parent empathic distress to observing their child’s pain was significantly associated with more general empathic distress, poorer perspective taking and more maladaptive emotion regulation strategy use (emotional suppression). Our findings underscore the involvement of parent affective responses in driving parent maladaptive behavioral responses to their child’s pain and emphasize the role of affective empathic distress as well as its regulation. In addition to providing information on its assessment, this empirical investigation provides novel insights into the construct of empathy in this context.

Perspective

This article presents initial data supporting the Parent Empathy in the Context of Pain model. Findings show involvement of parent affective responses in driving parent maladaptive behavioral responses to their child’s chronic pain and emphasize the role of affective empathic distress as well as its regulation.
看着你的孩子处于痛苦之中,这本身就是一种痛苦。在慢性疼痛的背景下,照顾者的反应可以有力地影响儿童疼痛相关功能。疼痛情境下的父母共情模型假设父母共情痛苦可能会阻碍对儿童疼痛的适应性反应,从而在父母反应和儿童功能之间的联系中发挥关键作用。本研究采用一套适用于父母的疼痛共情量表(P-EPS),在疼痛情境下的父母共情模型中,研究了父母共情与父母和子女疼痛相关构念之间的关系。数据来自190名患有慢性疼痛的青少年父母(170名母亲;8-18岁的儿童及其子女。结构方程模型(SEM)验证了理论模型的正确性。父母的疼痛相关信念通过对疼痛感同身受(情感困扰)和情绪调节(情绪抑制)的情感反应与行为反应相关联,而情感反应又与儿童的疼痛相关功能相关联。此外,父母观察孩子痛苦时的共情痛苦水平越高,一般共情痛苦水平越高,观点接受能力越差,情绪调节策略使用越不适应(情绪抑制)。我们的研究结果强调了父母情感反应在驱动父母对孩子疼痛的适应不良行为反应中的作用,并强调了情感共情痛苦及其调节的作用。除了提供有关其评估的信息外,本实证调查还为在这种情况下共情的构建提供了新的见解。观点:这篇文章提供了初步的数据来支持父母在痛苦情境中的共情模型。研究结果表明,父母情感反应参与了父母对儿童慢性疼痛的适应不良行为反应,并强调了情感共情痛苦的作用及其调控。
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引用次数: 0
Weight discrimination partially mediates the longitudinal relationship between Body Mass Index and pain 体重歧视在一定程度上介导了体重指数与疼痛之间的纵向关系。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-12-28 DOI: 10.1016/j.jpain.2024.104772
KayLoni Olson PhD , Ruth A. Hackett , Whitney Scott
Pain is common among individuals with high Body Mass Index (BMI). This study investigated weight discrimination as a mediator of the longitudinal relationship between BMI and the presence of moderate/severe pain among adults from the English Longitudinal Study of Ageing (ELSA) cohort. ELSA is a longitudinal study of middle-aged and older adults living in England. Data were taken from three consecutive waves. Demographics, BMI, and self-reported pain were collected at wave 4 (2008–2009), perceived weight discrimination at wave 5 (2010–2011,) and pain (no/mild vs moderate/severe) at wave 6 (2012–2013). Generalized linear models estimated the association of BMI at wave 4 (assessed continuously and dichotomized to obesity status BMI ≥30) with pain at wave 6, and weight discrimination at wave 5 as a mediator of this relationship. Models were adjusted for demographics and baseline pain. Complete data were available for n=5362 individuals. Continuous BMI was associated with future moderate/severe pain (b=1.05 SE=0.01, p<.01) and weight discrimination partially mediated this effect (b=1.00 SE=0.002, p=.05). Obesity status was also significant (b=1.43 SE=0.11, p<.01) but weight discrimination did not mediate the relationship (p=.13). Post hoc analyses were conducted among individuals with no/mild pain at baseline (n=3979.) BMI and obesity status were both associated with pain and weight discrimination mediated both pathways (ps<.05.) Weight discrimination partially mediated the relationship between BMI and future moderate/severe pain, especially among individuals with no/mild pain initially. Weight discrimination may be an overlooked contributor to the transition to more severe pain among individuals of higher body weight.

Perspective

Weight discrimination may be an overlooked contributor to pain among individuals of higher body weight, particularly transition from lower to higher impact states. Post hoc analyses indicate the effect may be specific, as other forms of discrimination did not mediate the relationship.
疼痛在身体质量指数(BMI)高的人群中很常见。本研究在英国老龄化纵向研究(ELSA)队列中调查了体重歧视作为BMI与中度/重度疼痛存在的纵向关系的中介。ELSA是一项对生活在英国的中老年成年人的纵向研究。数据取自三个连续的波。在第4期(2008-2009年)收集人口统计数据、BMI和自我报告的疼痛,在第5期(2010-2011年)收集感知到的体重歧视,在第6期(2012-2013年)收集疼痛(无/轻度vs中度/重度)。广义线性模型估计了第4波BMI(连续评估并二分类为肥胖状态BMI≥30)与第6波疼痛的关联,第5波体重歧视是这种关系的中介。根据人口统计学和基线疼痛调整模型。有n=5362人的完整资料。持续的BMI与未来的中/重度疼痛相关(b=1.05 SE=0.01, p
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引用次数: 0
Multisite pain among United States Veterans with posttraumatic stress disorder: Prevalence, predictors, and associations with symptom clusters 患有创伤后应激障碍的美国退伍军人的多部位疼痛:患病率、预测因素以及与症状群的关联
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-12-27 DOI: 10.1016/j.jpain.2024.104763
Joel N. Fishbein , Anne Malaktaris , Niloofar Afari , Matthew S. Herbert
Persistent pain in multiple distinct body sites is associated with poorer functional outcomes above and beyond pain intensity and interference. Veterans, and especially those with posttraumatic stress disorder (PTSD), may be at risk for multisite pain. However, the research to date characterizing this presentation is limited. This secondary analysis examined the prevalence of multisite pain in a cross-sectional sample of Veterans and explored demographic, military service-related, and PTSD symptom cluster variables associated with multisite pain among those with clinically significant PTSD symptoms. Participants were 4303 post-9/11 U.S. Veterans (16.55% female gender, 58.45% White/Caucasian, Mage = 35.52), of whom 1375 (31.95%) had clinically significant PTSD symptoms. Multisite pain was defined as endorsing pain that “bothered [me] a lot” in ≥3 body sites out of 5 on the Patient Healthcare Questionnaire-15. A total of 20.03% of all participants, and 40.00% of those with likely PTSD, reported multisite pain. Female gender (OR = 1.55), older age (OR = 1.70), minority race identification (White/Caucasian racial identity OR = 0.75), history of military sexual trauma (OR = 1.99), and spine, abdomen and joint/muscle injuries (ORs = 1.66–3.68) were associated with higher odds of multisite pain. Adjusting for these potential confounders, higher z-scores on the PTSD arousal/reactivity (OR = 1.58, p <.001) subscale was associated with higher multisite pain odds. In summary, multisite pain was common among Veterans with PTSD, especially those who experienced military sexual trauma or certain physical injuries. Multisite pain and PTSD may be associated due to a shared threat reactivity mechanism.

Perspective

This study investigates the rates and factors associated with having pain in three or more distinct body sites (multisite pain) among United States Veterans. The study findings highlight the unique importance of specific posttraumatic stress symptoms and experiences associated with multisite pain.
在多个不同的身体部位持续疼痛与较差的功能结果相关,超出疼痛强度和干扰。退伍军人,尤其是那些患有创伤后应激障碍(PTSD)的人,可能有多处疼痛的风险。然而,迄今为止关于这种表现的研究是有限的。这一次要分析检查了退伍军人多部位疼痛的流行程度,并探讨了具有临床显著PTSD症状的退伍军人中与多部位疼痛相关的人口统计学、兵役相关和PTSD症状聚类变量。参与者为4303名9/11后美国退伍军人(女性16.55%,白人/高加索58.45%,法师= 35.52),其中1375名(31.95%)有临床显著的PTSD症状。多部位疼痛被定义为在患者医疗保健问卷-15的5个身体部位中有3个以上“困扰[我]很多”的疼痛。总共有20.03%的参与者和40.00%的可能患有创伤后应激障碍的参与者报告了多部位疼痛。女性(OR = 1.55)、年龄较大(OR = 1.70)、少数民族种族认同(白人/高加索种族认同OR = 0.75)、军事性创伤史(OR = 1.99)、脊柱、腹部和关节/肌肉损伤(OR = 1.66-3.68)与多发部位疼痛相关。对这些潜在的混杂因素进行调整后,PTSD唤醒/反应性的z-得分较高(OR = 1.58, p
{"title":"Multisite pain among United States Veterans with posttraumatic stress disorder: Prevalence, predictors, and associations with symptom clusters","authors":"Joel N. Fishbein ,&nbsp;Anne Malaktaris ,&nbsp;Niloofar Afari ,&nbsp;Matthew S. Herbert","doi":"10.1016/j.jpain.2024.104763","DOIUrl":"10.1016/j.jpain.2024.104763","url":null,"abstract":"<div><div>Persistent pain in multiple distinct body sites is associated with poorer functional outcomes above and beyond pain intensity and interference. Veterans, and especially those with posttraumatic stress disorder (PTSD), may be at risk for multisite pain. However, the research to date characterizing this presentation is limited. This secondary analysis examined the prevalence of multisite pain in a cross-sectional sample of Veterans and explored demographic, military service-related, and PTSD symptom cluster variables associated with multisite pain among those with clinically significant PTSD symptoms. Participants were 4303 post-9/11 U.S. Veterans (16.55% female gender, 58.45% White/Caucasian, M<sub>age</sub> = 35.52), of whom 1375 (31.95%) had clinically significant PTSD symptoms. Multisite pain was defined as endorsing pain that “bothered [me] a lot” in ≥3 body sites out of 5 on the Patient Healthcare Questionnaire-15. A total of 20.03% of all participants, and 40.00% of those with likely PTSD, reported multisite pain. Female gender (OR = 1.55), older age (OR = 1.70), minority race identification (White/Caucasian racial identity OR = 0.75), history of military sexual trauma (OR = 1.99), and spine, abdomen and joint/muscle injuries (ORs = 1.66–3.68) were associated with higher odds of multisite pain. Adjusting for these potential confounders, higher <em>z-</em>scores on the PTSD arousal/reactivity (OR = 1.58, <em>p</em> &lt;.001) subscale was associated with higher multisite pain odds. In summary, multisite pain was common among Veterans with PTSD, especially those who experienced military sexual trauma or certain physical injuries. Multisite pain and PTSD may be associated due to a shared threat reactivity mechanism.</div></div><div><h3>Perspective</h3><div>This study investigates the rates and factors associated with having pain in three or more distinct body sites (<em>multisite pain</em>) among United States Veterans. The study findings highlight the unique importance of specific posttraumatic stress symptoms and experiences associated with multisite pain.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104763"},"PeriodicalIF":4.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"When you're in pain you do go into your shell" A community-based pain management programme co-designed with Māori whānau to address inequities to pain management - A qualitative case study. 一个基于社区的疼痛管理项目,与Māori whānau共同设计,旨在解决疼痛管理的不平等问题——一个定性案例研究。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-12-25 DOI: 10.1016/j.jpain.2024.104760
Cheryl Davies, Hemakumar Devan, Susan Reid, Jaquille Haribhai-Thompson, Dagmar Hempel, Isobel Joy Te Aho-White, Lisa Te Morenga

Chronic or persistent non-cancer pain disproportionately affects Māori - the Indigenous population of Aotearoa New Zealand (NZ) and their whānau (family and significant others). In a previous study with a Māori community service provider - Tū Kotahi Māori Asthma and Research Trust - Tū Kotahi, identified a need for a Kaupapa Māori (by Māori, for Māori) pain management programme (PMP) with embedded principles of Whānau Ora (care focusing on the wellbeing of the individual and their significant others as a collective). Using a qualitative case-study design, the main aims were to describe (1) the implementation of a community-based, whānau-focused PMP; (2) the participant experiences of the programme. This is community-based participatory action research guided by a Māori-centred research approach. Based on our previous co-design study with Tū Kotahi, a 6-week PMP (July - August 2021) was implemented at Kokiri Marae (community meeting place). Eight whānau living with persistent pain participated in the 6 sessions led by our Māori community partner and a pain management physiotherapist including a dedicated session on Rongoā Māori (Māori traditional treatment). Supporting resources were co-developed with our community partner, pain service clinicians, a Māori Health literacy expert, and a Māori illustrator. On completion, whānau reported enhanced confidence towards managing pain with "more tools to manage". The role of meaningful relationships, co-design, use of metaphors, and inclusion of traditional treatments - Rongoā were key aspects for the successful implementation. This initiative provides an exemplar for community and mainstream pain service partnership to address inequities in accessing pain management services for Māori. PERSPECTIVE: This study explains the key cultural processes of implementing a community-based pain management programme for Māori with persistent pain in Aotearoa New Zealand. The principles from our engagement could be applicable globally to engage with Indigenous and culturally and linguistically diverse communities with persistent pain to address longstanding health inequities.

慢性或持续性非癌性疼痛不成比例地影响Māori -新西兰(NZ)的土著人口及其whānau(大家庭)。在之前与Māori社区服务提供商tj Kotahi Māori哮喘和研究信托基金的一项研究中,tj Kotahi确定了对Kaupapa Māori(通过Māori,为Māori)疼痛管理计划(PMP)的需求,该计划包含Whānau Ora(关注个人及其重要他人作为一个集体的福祉)的原则。采用定性案例研究设计,主要目的是描述:(1)以社区为基础的whānau-focused PMP的实施;(2)学员对课程的体验。这是基于社区的参与性行动研究,以Māori-centred研究方法为指导。基于我们之前与tki Kotahi的共同设计研究,在Kokiri Marae(社区聚会场所)实施了为期6周的PMP(2021年7月至8月)。8名患有持续性疼痛的whānau患者参加了由我们的Māori社区合作伙伴和一名疼痛管理物理治疗师领导的6次会议,其中包括一场关于Rongoā Māori (Māori传统治疗)的专门会议。支持资源是与我们的社区合作伙伴、疼痛服务临床医生、Māori健康素养专家和Māori插画师共同开发的。完成后,whānau报告说,通过“更多的管理工具”,管理疼痛的信心增强了。有意义的关系的作用、共同设计、隐喻的使用和传统治疗方法(Rongoā)的纳入是成功实施的关键方面。这一举措为社区和主流疼痛服务伙伴关系提供了一个范例,以解决Māori获取疼痛管理服务方面的不平等问题。观点:本研究解释了新西兰奥特罗阿实施以社区为基础的疼痛管理方案Māori持续性疼痛的关键文化过程。我们参与的原则可以在全球范围内适用于与土著和文化和语言多样化的社区进行接触,以解决长期存在的健康不平等问题。
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引用次数: 0
Exposure to perinatal trauma modifies nociception and gene expression in the prefrontal cortex and hypothalamus of adolescent rats 暴露于围产期创伤改变青春期大鼠前额叶皮层和下丘脑的伤害感受和基因表达。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-12-25 DOI: 10.1016/j.jpain.2024.104762
Marissa Sgro , Zoe Kodila , Sabrina Salberg , Crystal N. Li , Madeleine J. Smith , James Freeman , Elaina Vlassopoulos , Sydney Harris , Sandy R. Shultz , Glenn R. Yamakawa , Melanie Noel , Richelle Mychasiuk
The perinatal period encompasses a critical window for neurodevelopment that renders the brain highly responsive to experience. Trauma, such as intimate partner violence (IPV) and early life stress/neglect, during this period negatively affects physical and mental health outcomes, including increasing ones risk for chronic pain. Although epigenetic programming likely contributes, the mechanisms that drive the relationship between perinatal trauma and adverse health outcomes, are not fully understood. Therefore, we explored the relationship between perinatal trauma (in utero exposure to IPV and/or early life neglect) and socio-emotional functioning, nociceptive sensitivity, and transcriptomic changes within the prefrontal cortex (PFC) and hypothalamus in dams and their adolescent offspring. Rat dams were randomly assigned to an IPV (i.e., combined mild traumatic brain injury and strangulation) or sham procedure during pregnancy. Following birth, offspring were subsequently assigned the early life neglect or control paradigm. In adolescence, offspring received a plantar incision or sham injury. Perinatal trauma altered nociception and emotional functioning in a sex-dependent manner when combined with the surgical procedure. We identified transcriptomic changes related to DNA transcription and expression within the PFC and hypothalamus of the dams. Examination of the offspring transcriptome highlighted impairment in immune regulation, dysfunction in stress-reactivity, as well as microglia activation. We also identified altered expression of genes associated with chronic pain. This demonstrates that perinatal trauma modifies offspring behaviour, including nociceptive sensitivity. We provide insight into the mechanisms that contribute to the chronification of pain, thereby informing future research targeted at the generation of prevention and therapeutic strategies.

Perspective

Perinatal trauma impaired cognitive, socio-emotional, and pain processing in offspring, while also inducing changes in gene expression, in both mothers and offspring. The findings highlight possible mechanisms responsible for intergenerational transmission of risk for chronic pain and provide targets for therapeutics which could potentially reverse perinatal-trauma induced epigenetic change.
围产期是神经发育的关键时期,使大脑对经验高度敏感。这一时期的创伤,如亲密伴侣暴力和早期生活压力/忽视,会对身心健康结果产生负面影响,包括增加患慢性疼痛的风险。虽然表观遗传程序可能起作用,但驱动围产期创伤和不良健康结果之间关系的机制尚不完全清楚。因此,我们探讨了围产期创伤(子宫内暴露于IPV和/或早期生活忽视)与公鼠及其青春期后代的社会情感功能、伤害敏感性和前额叶皮质(PFC)和下丘脑转录组学变化之间的关系。在怀孕期间,大鼠被随机分配到IPV(即合并轻度创伤性脑损伤和勒死)或假手术。出生后,后代随后被分配到早期生活忽视或控制范式。在青春期,后代接受足底切开或假损伤。围产期创伤与外科手术相结合时,以性别依赖的方式改变了伤害感觉和情感功能。我们发现了与坝的PFC和下丘脑DNA转录和表达相关的转录组学变化。对后代转录组的检查强调了免疫调节损伤、应激反应功能障碍以及小胶质细胞激活。我们还发现了与慢性疼痛相关的基因表达改变。这表明,围产期创伤改变后代的行为,包括伤害敏感性。我们深入了解了导致疼痛慢性化的机制,从而为未来针对预防和治疗策略的研究提供了信息。观点:围产期创伤会损害后代的认知、社会情感和疼痛处理,同时也会引起母亲和后代基因表达的变化。这些发现强调了慢性疼痛风险代际传递的可能机制,并提供了可能逆转围产期创伤引起的表观遗传变化的治疗靶点。
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引用次数: 0
Methodology for determining minimally clinically important differences in acute pain intensity with the double stopwatch technique. 利用双秒表技术确定急性疼痛强度最小临床意义差异的方法。
IF 4 2区 医学 Q1 CLINICAL NEUROLOGY Pub Date : 2024-12-15 DOI: 10.1016/j.jpain.2024.104759
Christopher J Miller, John T Farrar

Minimum clinically important differences (MCIDs) in acute pain intensity have not been well established. Conventional approaches for estimating MCIDs require an independent reference scale, with a threshold that must be presumed to accurately classify meaningful change in pain for all study participants, to serve as an anchor. The double stopwatch technique is the gold standard for measuring the time to meaningful relief, where participants actively press the second stopwatch when they experience pain relief that is meaningful to them. This technique eliminates the problem of misclassification with arbitrary anchors at a single time point, but the censored nature of the data is not amenable for determining MCIDs using standard methods. We propose a stopwatch-based MCID methodology that employs the double stopwatch technique to identify individualized thresholds for meaningful change in pain. This approach enables direct classification of changes in pain for each participant based on whether they perceived the change as meaningful and whether it exceeded the study cut-off being tested. Pain values of participants who do not achieve meaningful relief are incorporated into the analysis to address censoring and avoid bias. The performance (e.g., sensitivity, specificity) of different thresholds to serve as an MCID can be estimated using standard approaches with variance estimates derived by cluster bootstrapping. The advantages of the stopwatch-based MCID methodology are illustrated relative to a conventional approach using data from a randomized trial in third molar extraction. PERSPECTIVE: This article describes a methodology for determining MCIDs using the double stopwatch technique, the gold standard for assessing meaningful changes in acute pain. This methodology can be used to establish MCIDs in different acute pain settings, providing a useful basis to evaluate the meaningfulness of clinical trial results.

急性疼痛强度的最小临床重要差异(MCIDs)尚未得到很好的确定。估计mcid的传统方法需要一个独立的参考量表,必须假设一个阈值,以准确分类所有研究参与者的有意义的疼痛变化,作为一个锚点。双秒表技术是衡量有意义的缓解时间的黄金标准,当参与者体验到对他们有意义的疼痛缓解时,他们会主动按下第二个秒表。该技术消除了在单个时间点上使用任意锚点进行错误分类的问题,但是数据的审查性质不适合使用标准方法确定mcid。我们提出了一种基于秒表的MCID方法,该方法采用双秒表技术来识别疼痛有意义变化的个性化阈值。这种方法可以根据每个参与者是否认为这种变化有意义以及是否超出了被测试的研究截止范围,对疼痛的变化进行直接分类。没有获得有意义的缓解的参与者的疼痛值被纳入分析,以解决审查和避免偏见。作为MCID的不同阈值的性能(例如,灵敏度,特异性)可以使用标准方法和由聚类自举得出的方差估计来估计。基于秒表的MCID方法的优势是相对于传统的方法说明使用数据随机试验的第三磨牙提取。观点:本文描述了一种使用双秒表技术确定mcid的方法,这是评估急性疼痛有意义变化的金标准。该方法可用于在不同急性疼痛环境下建立MCIDs,为评估临床试验结果的意义提供了有用的依据。数据可用性:本研究中作为说明性示例的参与者水平数据由行业赞助商提交给FDA,可能不会公开发布。作为补充附录,提供了一个模拟数据集的R统计代码来说明所提出的方法。
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引用次数: 0
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Journal of Pain
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