Materials Science & Engineering C-Materials for Biological Applications最新文献_第5页

Mesoporous polydopamine loaded with silver nanoparticles and quercetin for bacterial keratitis treatment through antibacterial and anti-angiogenic mechanisms 负载银纳米粒子和槲皮素的介孔聚多巴胺通过抗菌和抗血管生成机制治疗细菌性角膜炎。

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-14 DOI: 10.1016/j.bioadv.2026.214715

Meiliang Wu , Rong Liu , Weijin Nan , Can Meng , Wenxin Zhang , Qingyu Guo , Hong Wu

Bacterial keratitis (BK) is a serious blinding eye disease, with pathological features mainly including corneal stromal opacity, edema, inflammatory response, and corneal neovascularization (CoNV). Timely intervention and treatment are required in clinical practice. In this study, we successfully prepared mesoporous polydopamine (MPDA) using a soft-template method, and further introduced silver nanoparticles (Ag NPs) and quercetin (Que) onto its surface, resulting in the effective preparation of a Q/AMP nanocomposite with dual functions of anti-angiogenesis and antibacterial activity, which is expected to be applied in the prevention and treatment of BK. The experimental results demonstrated that Q/AMP, based on favorable in vitro and in vivo biocompatibility, effectively inhibited the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs), as well as markedly inhibited CoNV in rats. In the in vitro antibacterial experiment, Q/AMP exhibited broad-spectrum and highly efficient antibacterial activity. In the BK animal model, Q/AMP achieved a 97.0% antibacterial rate, higher than Levofloxacin (LVFX) eye drops (77.4%), and Q/AMP showed a greater therapeutic effect, reducing corneal opacity score from 2.5 with LVFX to 0.8 and effectively alleviating ocular symptoms. Therefore, this study presents a promising new strategy for the treatment of infectious keratitis. Q/AMP has demonstrated strong capabilities in antibacterial, anti-angiogenic, and anti-inflammatory aspects, which may attract more attention to the deeper integration of biomaterials and infectious keratitis research.

细菌性角膜炎（BK）是一种严重的致盲眼病，其病理特征主要包括角膜基质混浊、水肿、炎症反应和角膜新生血管（CoNV）。在临床实践中需要及时干预和治疗。在本研究中，我们采用软模板法成功制备了介孔聚多巴胺（MPDA），并在其表面进一步引入银纳米粒子（Ag NPs）和槲皮素（Que），从而有效制备了具有抗血管生成和抗菌双重功能的Q/AMP纳米复合材料，有望应用于BK的防治。基于良好的体外和体内生物相容性，有效抑制人脐静脉内皮细胞（HUVECs）的增殖、迁移和成管，并显著抑制大鼠体内的CoNV。在体外抗菌实验中，Q/AMP表现出广谱、高效的抗菌活性。在BK动物模型中，Q/AMP的抗菌率达到97.0%，高于左氧氟沙星（LVFX）滴眼液的77.4%，并且Q/AMP的治疗效果更明显，将角膜混浊评分从LVFX的2.5分降低到0.8分，有效缓解眼部症状。因此，本研究为感染性角膜炎的治疗提供了一个有希望的新策略。Q/AMP在抗菌、抗血管生成和抗炎方面表现出较强的能力，可能会引起人们对生物材料与感染性角膜炎研究更深层次结合的关注。

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引用次数: 0

Polymeric micelles for encapsulation of plant-derived bioactives: a decade of advances in antimicrobial, antitumor, and antioxidant applications 高分子胶束包封植物源性生物活性物质：抗菌、抗肿瘤和抗氧化应用的十年进展

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-11 DOI: 10.1016/j.bioadv.2026.214713

Astrid Corrales , James Villar , Ana Lívia de Carvalho Bovolato , Alberto Gomes Tavares Júnior , Rita de Cássia Lacerda Brambilla Rodrigues , Marlus Chorilli , Daniele Ribeiro de Araujo , André Moreni Lopes

This 10-year review provides a comprehensive overview of advances in the use of polymeric micelles (PMs) for the encapsulation of bioactive compounds derived from renewable green sources. PMs have emerged as highly versatile nanocarriers that capable of enhancing the solubility, stability, and bioavailability of poorly water-soluble compounds while enabling controlled and targeted release. Across the literature, PM formulations typically exhibit nanoscale sizes ranging from ∼10 to 200 nm, low polydispersity indices (generally <0.300), and high encapsulation efficiencies, commonly ranging from ∼70 to >95%. By protecting plant-derived bioactives from degradation and enabling sustained release profiles over hours to days, PMs significantly improve antimicrobial, antitumor, and antioxidant performance, frequently reducing effective concentrations compared to free compounds. The incorporation of green-source biomolecules adds further value through their natural origin, biocompatibility, low toxicity, and alignment with sustainability-driven pharmaceutical development. This review critically analyzes the physicochemical parameters governing PM performance, including particle size, surface charge, encapsulation efficiency, and release kinetics, and correlates these features with biological activity and therapeutic outcomes. Special emphasis is placed on key formulation strategies reported over the past decade, highlighting PMs as a rapidly evolving and high-performance platform for the development of safer, more efficient, and innovative nanomedicine.

这10年的回顾提供了一个全面的综述，在使用聚合物胶束（pm）包封生物活性化合物从可再生的绿色来源。pm已经成为高度通用的纳米载体，能够提高水溶性差化合物的溶解度、稳定性和生物利用度，同时实现控制和靶向释放。在文献中，PM配方通常具有纳米级尺寸范围为~ 10至200nm，低多分散性指数（通常为<；0.300）和高封装效率，通常范围为~ 70%至>；95%。通过保护植物源性生物活性免遭降解，并在数小时至数天内实现持续释放，pmms显著提高了抗菌、抗肿瘤和抗氧化性能，与游离化合物相比，pmms的有效浓度经常降低。绿色来源生物分子的结合通过其天然来源，生物相容性，低毒性以及与可持续驱动的药物开发相一致而增加了进一步的价值。这篇综述批判性地分析了控制PM性能的物理化学参数，包括粒径、表面电荷、包封效率和释放动力学，并将这些特征与生物活性和治疗结果联系起来。特别强调了过去十年中报告的关键配方策略，强调了pm作为开发更安全，更有效和创新的纳米药物的快速发展和高性能平台。

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引用次数: 0

A novel antimicrobial peptide AH-12 attenuates mitochondrial response to inflammatory stimuli and prevents periodontitis via antibacterial and anti-inflammatory effects 一种新型抗菌肽AH-12减弱线粒体对炎症刺激的反应，并通过抗菌和抗炎作用预防牙周炎

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-09 DOI: 10.1016/j.bioadv.2026.214711

Yuanchen Wang , Shuting Zhang , Jinrong Sun , Qian Zhang , Xi Zhang

Antibiotic-assisted periodontal therapy remains a primary clinical strategy, yet the rising prevalence of bacterial resistance severely compromises its therapeutic efficacy. To address this challenge, antimicrobial peptides (AMPs) have emerged as promising alternatives owing to their distinct antibacterial mechanisms. Here, we developed a novel antimicrobial peptide, AH-12, by systematically optimizing P-113—the minimal inhibitory fragment of human salivary Histatin 5—through N-terminal modification, amidation, and acetylation. In vitro evaluations demonstrated potent inhibitory effects of AH-12 against key oral pathogens (Fusobacterium nucleatum, Porphyromonas gingivalis, and Streptococcus gordonii), achieved via bacterial membrane lysis and suppression of FadA adhesin secretion in F. nucleatum. Beyond its antibacterial properties, AH-12 targeted inflammatory regulation by modulating mitochondrial function. Mitochondria, as early responders to inflammation, drive inflammatory cascades via Ca²⁺-dependent signaling. Remarkably, AH-12 stabilized mitochondrial Ca²⁺ levels, thereby attenuating mitochondrial reactive oxygen species (mtROS) overproduction and mitochondrial DNA (mtDNA) release, which collectively contributed to its robust anti-inflammatory effects. In order to minimize the loss of medication during administration and to better fit the shape of the periodontal pockets, a GelMA hydrogel (GelMA@AH-12) was engineered for controlled release applications. In vivo studies validated the outstanding efficacy of GelMA@AH-12, highlighting AH-12 as a transformative candidate for periodontitis treatment.

抗生素辅助牙周治疗仍然是一种主要的临床策略，但细菌耐药性的日益流行严重影响了其治疗效果。为了解决这一挑战，抗菌肽（AMPs）由于其独特的抗菌机制而成为有希望的替代品。在这里，我们通过n端修饰、酰胺化和乙酰化，系统地优化了人类唾液组蛋白5的最小抑制片段p -113，开发了一种新的抗菌肽AH-12。体外评估表明，AH-12对口腔主要病原体（核梭菌、牙龈卟啉单胞菌和戈登链球菌）有有效的抑制作用，这是通过细菌膜裂解和抑制核梭菌中FadA粘连素的分泌来实现的。除了抗菌特性，AH-12还通过调节线粒体功能来调节炎症。线粒体作为炎症的早期反应者，通过Ca2+依赖性信号驱动炎症级联反应。值得注意的是，AH-12稳定了线粒体Ca2+水平，从而减少了线粒体活性氧（mtROS）的过量产生和线粒体DNA （mtDNA）的释放，这共同促成了其强大的抗炎作用。为了最大限度地减少药物在给药过程中的损失，并更好地适应牙周袋的形状，GelMA水凝胶（GelMA@AH-12）被设计用于控释应用。体内研究证实了GelMA@AH-12的卓越功效，突出了AH-12作为牙周炎治疗的变革性候选药物。

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引用次数: 0

An antagomiR-loaded β-peptide hydrogel promotes functional recovery in mice post-ischaemic stroke 一种含有安他戈米的β肽水凝胶促进小鼠缺血性中风后的功能恢复。

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-09 DOI: 10.1016/j.bioadv.2026.214712

Yi-Kai Chen , Ketav Kulkarni , Marie-Isabel Aguilar , Brad R.S. Broughton , Mark P. Del Borgo

Ischaemic stroke is a leading cause of mortality and disability, arising from interrupted cerebral blood flow and subsequent neuronal death. MicroRNAs, particularly miR-181a, have emerged as promising therapeutic targets due to their roles in regulating apoptosis and oxidative stress. While miR-181a inhibition using antagomirs can improve neuronal survival, translation to clinical practice is hampered by inefficient delivery across the blood–brain barrier and poor pharmacokinetics. Here, we developed a series of novel β-peptide hydrogels as injectable delivery systems to encapsulate and release a miR-181a antagomir in a controlled manner within the infarct region. β-peptides were synthesised with varied incorporation of β-homolysine residues to modulate electrostatic interactions with nucleic acids. The resulting hydrogels demonstrated shear-thinning and self-healing properties, stiffness values within the physiological range of brain tissue and tunable nucleic acid release profiles extending over 3 weeks. Following photothrombotic stroke in mice, intracerebral injection of antagomir-loaded hydrogel achieved precise infarct delivery and sustained presence for at least 7 days. Although infarct size reduction was modest, functional recovery, measured by improved motor coordination in the hanging wire test, was significantly enhanced in the hydrogel-antagomir group compared with controls. These findings highlight β-peptide hydrogels as promising platforms for localised, sustained delivery of nucleic acid therapeutics. This work establishes proof-of-concept for hydrogel-mediated miRNA delivery in stroke and provides a foundation for further optimisation in clinically relevant models.

缺血性中风是死亡和残疾的主要原因，由脑血流中断和随后的神经元死亡引起。microrna，特别是miR-181a，由于其在调节细胞凋亡和氧化应激中的作用，已经成为有希望的治疗靶点。虽然使用安塔戈米抑制miR-181a可以改善神经元存活，但通过血脑屏障的低效递送和不良的药代动力学阻碍了转化为临床实践。在这里，我们开发了一系列新型β-肽水凝胶作为可注射递送系统，以控制方式在梗死区域内封装和释放miR-181a安塔戈莫。通过掺入不同的β-高赖氨酸残基来合成β-肽，以调节与核酸的静电相互作用。所得水凝胶表现出剪切变薄和自愈特性，在脑组织的生理范围内的刚度值和可调的核酸释放谱延长超过3周。在小鼠光血栓性中风后，脑内注射装有安他哥米的水凝胶实现了精确的梗死递送，并持续存在至少7天。尽管梗死面积减少幅度不大，但与对照组相比，水凝胶-安他戈米尔组的功能恢复（通过吊丝试验中运动协调性的改善来衡量）明显增强。这些发现突出了β-肽水凝胶作为有前途的平台，用于核酸治疗的局部持续递送。这项工作建立了脑卒中中水凝胶介导的miRNA传递的概念验证，并为进一步优化临床相关模型提供了基础。

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引用次数: 0

Superparamagnetic Fe3O4 nanoclusters for cancer therapy and metastasis prevention via synergistic chemotherapy and NETs degradation 超顺磁性Fe3O4纳米团簇通过协同化疗和NETs降解治疗癌症和预防转移。

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-07 DOI: 10.1016/j.bioadv.2026.214709

Liqin Xie , Tianyi Zeng , Dan Li , Wenke Chang , Shenglu Ji , Zichun Hua

The overexpression of neutrophil extracellular traps (NETs) serves as a critical biomarker and mediator of tumorigenesis and metastasis. By inhibiting their formation or degrading existing structures, therapeutic strategies targeting NETs have shown promising potential in cancer treatment and metastasis prevention. Deoxyribonuclease I (DNase), while effective in NETs degradation, suffers from rapid plasma clearance, necessitating delivery vehicles to prolong its therapeutic activity. In this study, we developed superparamagnetic Fe₃O₄ nanoclusters via a one-step solvothermal method for co-delivery of doxorubicin (DOX) and DNase. The resulting nanoplatform demonstrated: (1) enhanced magnetic retention at tumor sites for improved local drug concentration and targeted delivery, and (2) synergistic therapeutic effects under alternating magnetic field (AMF) exposure, combining magnetic hyperthermia with chemotherapy while simultaneously remodeling the tumor microenvironment through NETs degradation. Comprehensive evaluations revealed that this combined approach significantly enhanced antitumor efficacy compared to monotherapies, with the additional benefit of metastasis prevention through tumor microenvironment modulation. This multifunctional nanoplatform thus represents a promising strategy for synergistic cancer therapy, addressing both primary tumor control and metastatic suppression.

中性粒细胞胞外陷阱（NETs）的过度表达是肿瘤发生和转移的关键生物标志物和中介。通过抑制其形成或降解现有结构，靶向NETs的治疗策略在癌症治疗和预防转移方面显示出良好的潜力。脱氧核糖核酸酶I （DNase）虽然对NETs降解有效，但血浆清除速度很快，因此需要递送载体来延长其治疗活性。在这项研究中，我们通过一步溶剂热法开发了超顺磁性的Fe3O4纳米团簇，用于共同递送阿霉素（DOX）和dna酶。由此产生的纳米平台证明：(1)增强了肿瘤部位的磁保留，提高了局部药物浓度和靶向递送；(2)在交变磁场（AMF）暴露下的协同治疗效果，将磁热疗与化疗结合起来，同时通过NETs降解重塑肿瘤微环境。综合评价显示，与单一疗法相比，这种联合疗法显著提高了抗肿瘤疗效，并通过调节肿瘤微环境预防转移。因此，这种多功能纳米平台代表了一种很有前途的协同癌症治疗策略，既能控制原发肿瘤，又能抑制转移性肿瘤。

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引用次数: 0

3D-printed carbonate apatite scaffolds inspired by cuttlebone biomechanics and blood flow dynamics for layer-by-layer collapse and spatial bone formation 3d打印碳酸盐磷灰石支架，灵感来自海螵蛸生物力学和血流动力学，用于逐层塌陷和空间骨形成

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-07 DOI: 10.1016/j.bioadv.2026.214710

Ahmad Nazir Taleb Alashkar , Koichiro Hayashi , Kunio Ishikawa

In bone tissue engineering, scaffolds are required to resist mechanical impact and promote bone regeneration, both are highly dependent on the structure of the scaffolds. In this study, we aimed to develop scaffolds inspired by the uniquely layered and curved structure of cuttlebone, which underlies its distinctive biomechanical behavior, and it is hypothesized to promote favorable blood flow dynamics. The scaffolds were composed of carbonate apatite, bone mineral analog, and designed with three structures: one with straight interlayer walls (SW) and two with curved walls (CW). In the CW designs, the bottom curvature amplitude was fixed at 0.3 mm, while the top was 0.6 mm (CW-2) or 0.9 mm (CW-3). Upon compression, CW-3 scaffolds exhibited a distinct layer-by-layer collapse pattern, whereas SW and CW-2 scaffolds collapsed as a whole. Computational fluid dynamics revealed that SW scaffolds had uniformly fast blood flow throughout their channels. Compared to SW, CW scaffolds showed reduced flow velocities across their channels, with markedly slower flow near the concave regions of their curved walls. These flow dynamics affected the distribution of wall shear stress (WSS); CW scaffolds showed a higher proportion of WSS values favorable for cell adhesion and proliferation than SW. At both 4 and 12 weeks post-surgery, the in vivo bone formation in the CW scaffold groups was significantly greater than that observed in the SW scaffold and sham groups. This study elucidates CW-3 structure offers both mechanical resilience and enhanced bone formation, representing a significant advancement in the field of bone tissue engineering.

在骨组织工程中，支架需要抵抗机械冲击和促进骨再生，这两者都高度依赖于支架的结构。在这项研究中，我们的目标是开发受海螵蛸独特的分层和弯曲结构启发的支架，这是其独特的生物力学行为的基础，并且假设它可以促进有利的血流动力学。支架由碳酸盐磷灰石（骨矿物类似物）组成，并设计了三种结构：一种是直层间壁（SW），两种是弯曲壁（CW）。在连续波设计中，底部曲率幅值固定为0.3 mm，顶部曲率幅值分别为0.6 mm （CW-2）和0.9 mm （CW-3）。压缩后，CW-3支架呈现出明显的逐层坍塌模式，而SW和CW-2支架呈现整体坍塌。计算流体动力学表明，SW支架在其通道中具有均匀快速的血流。与SW相比，CW支架的通道流速降低，弯曲壁面凹区附近的流速明显减慢。这些流动动力学影响了壁面剪应力（WSS）的分布；CW支架中有利于细胞粘附和增殖的WSS值比例高于SW。术后4周和12周，CW支架组的体内骨形成明显大于SW支架组和sham支架组。本研究阐明了CW-3结构具有机械弹性和增强骨形成的双重作用，代表了骨组织工程领域的重大进展。

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引用次数: 0

Trifunctional nanoparticles accelerate diabetic wounds healing via oxidative-immune-vascular coordination 三功能纳米颗粒通过氧化-免疫-血管协调加速糖尿病伤口愈合。

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-06 DOI: 10.1016/j.bioadv.2025.214682

Yanming Zuo , Qin Cao , Zhihao Jin , Zhiyi Feng , Minhui Liang , Zhiqiang Cao , Haiyang Xia , Huixing Lin , Xiaokun Li , Zhouguang Wang

Current treatments for diabetic wounds remain a critical clinical challenge due to their suboptimal therapeutic efficacy. Patients with diabetic wounds suffer from prolonged inflammation, ROS overproduction, and impaired angiogenesis, creating a self-perpetuating healing cycle. Here, we report a biomimetic trifunctional nanoparticle comprising nanozymes (Heme@BSA), a ROS-scavenging core, a pro-angiogenic bFGF payload, and a pH-responsive H₂S-eluting MnS shell. This design enables spatiotemporal synergism to mitigate the self-perpetuating healing cycle in diabetic wounds, via converting ROS into O₂; microenvironment- triggered H₂S release to ameliorate excessive inflammation; and sustained bFGF delivery to promote cell proliferation and migration, facilitate well-organized collagen realignment, and expedite epithelialization. Comprehensive mechanistic analyses reveal that nanozyme- transmuted O₂ reduces HIF-1α-stabilized bFGF-mediated revascularization; H₂S-driven Nrf-2 activation and HO-1 upregulation effectively assist the nanozyme in overcoming the acute ROS microenvironment via robust antioxidant and anti-apoptotic capabilities; and bFGF-supported proliferation effectively amplifies H₂S-initiated macrophage polarization in the wound core. Collectively, our investigation offers an oxidative-immune-vascular coordinated approach for diabetic wound repair, highlighting its translational potential in the management of diabetic wounds.

目前治疗糖尿病伤口仍然是一个关键的临床挑战，由于其治疗效果不佳。糖尿病伤口患者会经历长期的炎症、活性氧过量产生和血管生成受损，从而形成一个自我延续的愈合周期。在这里，我们报道了一个仿生三功能纳米颗粒，包括纳米酶（Heme@BSA），一个清除ros的核心，一个促血管生成的bFGF负载和一个ph响应的H₂s洗脱MnS壳。该设计通过将活性氧转化为O₂，实现时空协同作用，以减轻糖尿病伤口的自我延续愈合周期；微环境触发的H₂S释放，改善过度炎症；持续的bFGF递送促进细胞增殖和迁移，促进组织良好的胶原蛋白重组，加速上皮化。综合机制分析表明，纳米酶转化的O₂可降低hif -1α稳定的bfgf介导的血运重建；H₂s驱动的Nrf-2激活和HO-1上调通过强大的抗氧化和抗凋亡能力有效地帮助纳米酶克服急性ROS微环境；bfgf支持的增殖有效地放大了H₂s引发的伤口核心巨噬细胞极化。总的来说，我们的研究为糖尿病伤口修复提供了一种氧化-免疫-血管协调的方法，突出了其在糖尿病伤口管理中的转化潜力。

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引用次数: 0

Polymer microspheres in endovascular therapy: From fundamental research to clinical application 聚合物微球在血管内治疗中的应用：从基础研究到临床应用。

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-06 DOI: 10.1016/j.bioadv.2025.214695

Andrey N. Kuskov , Pavel P. Kulikov , Pavel A. Yudaev , Anton S. Tupikov , Ekaterina A. Lesovaya , Anton A. Keskinov , Alexander A. Artyukhov

This review highlights the current state of research in the field of the use of microspheres based on natural and synthetic polymers for embolization of hepatocellular carcinoma vessels, embolization of arteries in patients with paragangliomas, uterine myoma, prostatic hyperplasia and hemorrhoids. Particular attention in the review is paid to clinical studies of various sizes of microspheres to determine the effectiveness and safety of embolization processes. Based on the analysis of works over the past five years in the field of chemoembolization and radioembolization, it can be concluded that the most promising polymer matrices for the development of microspheres are cross-linked natural polymers, such as gelatin and chitosan. It has been established that polyvinyl alcohol microspheres and liquid embolizing agents based on ethylene-vinyl alcohol copolymer are effective and safe for preoperative embolization of patients with paragangliomas of various localizations. It is shown that the most promising embolizing agents for the treatment of uterine myoma, prostate hyperplasia and internal hemorrhoids are microspheres of cross-linked trisacryl coated with gelatin and microspheres based on polymethyl methacrylate coated with polyphosphazene. Unlike previous reviews focusing on single applications, this work provides a unique cross-disciplinary analysis of polymer microsphere embolization across multiple clinical specialties, highlighting material-design-clinical outcome relationships. The review may be of interest to bioengineers, materials scientists, chemists, and physicians working in the field of biopolymer materials and interventional therapies.

本文综述了基于天然聚合物和合成聚合物的微球在肝癌血管栓塞、副神经节瘤、子宫肌瘤、前列腺增生和痔疮患者动脉栓塞方面的研究现状。本综述特别关注不同尺寸微球的临床研究，以确定栓塞过程的有效性和安全性。通过对近5年来化学栓塞和放射栓塞领域研究成果的分析，认为明胶和壳聚糖等交联天然聚合物是发展微球最有前途的聚合物基质。已经证实聚乙烯醇微球和基于乙烯-乙烯醇共聚物的液体栓塞剂用于不同定位的副神经节瘤患者的术前栓塞是有效和安全的。结果表明，在子宫肌瘤、前列腺增生和内痔治疗中最有前途的栓塞剂是明胶包被交联三丙烯酸酯微球和聚磷腈包被聚甲基丙烯酸甲酯微球。不像以前的评论只关注单一应用，这项工作提供了一个独特的跨学科分析聚合物微球栓塞跨多个临床专业，突出材料-设计-临床结果的关系。这篇综述可能对从事生物聚合物材料和介入治疗领域的生物工程师、材料科学家、化学家和医生感兴趣。

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引用次数: 0

Device surface-functionalized ac-SDKP nanoassemblies accelerate endothelial recovery through dual anti-inflammatory and endothelial homeostatic mechanisms 设备表面功能化的ac-SDKP纳米组件通过双重抗炎和内皮稳态机制加速内皮恢复。

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-06 DOI: 10.1016/j.bioadv.2026.214703

Li Li , Huanran Wang , Lai Wei , Jinyu Su , Zheng Zeng , Jianying Tan , Dan Zou , Junying Chen

While stents are cornerstone treatments for atherosclerosis, in-stent restenosis remains a challenge. Engineering stent surfaces with specific biochemical signals can prevent this by promoting the crucial and timely regeneration of the endothelium. In this work, Ac-SDKP (N-Acetyl-Ser-Asp-Lys-Pro), an anti-inflammatory and endothelial homeostasis-regulating peptide, was incorporated into a blood-compatible PAMAM (poly-amidoamine) platform to yield pro-endothelial repair nanoassemblies. Ac-SDKP nanoassemblies attenuated macrophage activity and TNF α secretion, as well as neutrophil myeloperoxidase release. Simultaneously, the modified surface enhanced endothelial cell (EC) activity, proliferation and protection. The immobilized Ac-SDKP suppressed both extrinsic (caspase 8 pathway) and intrinsic (cytochrome c pathway) apoptotic signal, along with caspase-1-mediated inflammatory death, while also activating PI3K pathway to exert an anti-death effect. Furthermore, the nanoassemblies also suppressed the transmission of EC dysfunction signals by inhibiting the IKKα-RELB pathway, including monocyte chemoattractant protein-1 (linked to inflammation) and tissue factor (promoting coagulation), thereby helping to protect endothelial function. Collectively, this novel modification strategy promoted endothelial regeneration, suppressed neointimal hyperplasia, and reduced inflammatory cell infiltration in Sprague Dawley rats. In summary, constructing Ac-SDKP nanoassemblies on a PAMAM framework promotes endothelial recovery through anti-inflammatory and endothelial protection mechanisms, offering a potential approach for preventing post-implantation complications.

虽然支架是动脉粥样硬化的基础治疗方法，但支架内再狭窄仍然是一个挑战。具有特定生化信号的工程支架表面可以通过促进内皮细胞的及时再生来防止这种情况的发生。在这项工作中，Ac-SDKP （n -乙酰基- ser - asp - lys - pro）是一种抗炎和内皮稳态调节肽，被纳入血液相容的PAMAM（聚氨基胺）平台，以产生促内皮修复纳米组装体。Ac-SDKP纳米组件降低巨噬细胞活性和TNF α分泌，以及中性粒细胞髓过氧化物酶释放。同时，改性后的表面增强了内皮细胞（EC）的活性、增殖和保护作用。固定化Ac-SDKP抑制外源性（caspase 8通路）和内源性（细胞色素c通路）凋亡信号，以及caspase-1介导的炎症性死亡，同时激活PI3K通路，发挥抗死亡作用。此外，纳米组件还通过抑制IKKα-RELB途径抑制EC功能障碍信号的传递，包括单核细胞趋化蛋白-1（与炎症有关）和组织因子（促进凝血），从而有助于保护内皮功能。总的来说，这种新的修饰策略促进了Sprague Dawley大鼠的内皮细胞再生，抑制了新生内膜增生，减少了炎症细胞浸润。总之，在PAMAM框架上构建Ac-SDKP纳米组件通过抗炎和内皮保护机制促进内皮恢复，为预防植入后并发症提供了潜在的方法。

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引用次数: 0

Synergistic modulation of inflammation and angiogenesis by a polyphenol-functionalized MOF nanozyme for enhancing wound closure 多酚功能化MOF纳米酶促进伤口愈合的炎症和血管生成的协同调节。

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications

Pub Date : 2026-01-06 DOI: 10.1016/j.bioadv.2026.214707

Beibei Han , Yidan Xia , Kai Liu , Ruichu Li , Jiangbo Shao , Mengke Wang , Shun Wang , Bin Liu

Persistent inflammation, excessive oxidative stress, and impaired angiogenesis are persistent challenges that adversely affect skin wound healing, which are particularly prominent in diabetic wounds and often lead to hindered repair processes. Bioactive materials with integrated anti-inflammatory, reactive oxygen species (ROS) scavenging, and angiogenesis-promoting functions are emerging as novel therapeutic strategies for enhancing wound healing. Therefore, we pioneered the development of a tannic acid -functionalized cerium-based metal-organic framework (CeMT) with multi-enzyme mimetic activities. Experiments in vitro and in vivo confirm CeMT's good biocompatibility. By mimicking the activities of superoxide dismutase and catalase, CeMT efficiently catalyzes the decomposition of ROS through a cascade reaction to generate oxygen, thereby eliminating excess ROS, alleviating hypoxia in the wound area, and reducing inflammatory responses. Furthermore, CeMT promotes macrophage polarization, angiogenesis, and collagen deposition, which accelerates the skin wound healing process. Proteomic analysis further indicated that CeMT inhibits the formation of neutrophil extracellular traps and remodels the inflammatory microenvironment of the wound. The proposed CeMT-based approach represents a safe, efficient, and clinically promising nanotherapeutic strategy for the treatment of large-scale acute and healing-impaired wounds, such as diabetic wounds.

持续的炎症、过度的氧化应激和血管生成受损是持续的挑战，对皮肤伤口愈合产生不利影响，这在糖尿病伤口中尤为突出，往往导致修复过程受阻。具有抗炎、清除活性氧（ROS）和促进血管生成功能的生物活性材料正在成为促进伤口愈合的新治疗策略。因此，我们率先开发了具有多酶模拟活性的单宁酸功能化铈基金属有机骨架（CeMT）。体外和体内实验证实CeMT具有良好的生物相容性。CeMT通过模仿超氧化物歧化酶和过氧化氢酶的活性，通过级联反应高效催化ROS分解生成氧气，从而消除多余的ROS，缓解创面缺氧，减轻炎症反应。此外，CeMT促进巨噬细胞极化、血管生成和胶原沉积，从而加速皮肤伤口愈合过程。蛋白质组学分析进一步表明，CeMT抑制中性粒细胞胞外陷阱的形成，重塑伤口的炎症微环境。提出的基于cemt的方法代表了一种安全、有效和临床有前景的纳米治疗策略，可用于治疗大规模急性和愈合受损伤口，如糖尿病伤口。

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引用次数: 0