Neurological disorders represent a devastating global health crisis, and the blood-brain barrier (BBB) remains a major obstacle for their treatment. Conventional strategies for BBB opening, including direct intracranial injection, osmotic disruption, receptor-mediated transcytosis, and nanoparticle carriers, often suffers from surgical invasiveness, systemic toxicity, poor biodistribution, and off-target effects. Ultrasound-mediated drug delivery has emerged as a revolutionary non-invasive technology for transient and targeted BBB opening, enabling enhanced penetration of therapeutic agents into the central nervous system. This review comprehensively summarizes the mechanisms underlying ultrasound-based delivery with focus on current delivery platforms including microbubble (MB)-assisted, nanoparticle-based, and MB-nanoparticle composite strategies. Furthermore, we highlight recent advances in the application of focused ultrasound (FUS) combined with MBs for the treatment of Alzheimer's disease, Parkinson's disease, and glioma. Finally, we discuss emerging technologies such as sonodynamic therapy and ultrasound-controlled magnetic nanorobots, while also addressing current challenges in this field. This review underscores the transformative potential of ultrasound-mediated drug delivery as a versatile platform for precision neurology. It also prospects future directions for advancing multidisciplinary research and clinical translation.
{"title":"Ultrasound-mediated blood-brain barrier opening for targeted neurological drug delivery","authors":"Zibo Qin , Zhangbaihe Wang , Cancan Gao , Xueqing Yong , Yue Hua , Ying Zhou , Jinbing Xie","doi":"10.1016/j.bioadv.2026.214754","DOIUrl":"10.1016/j.bioadv.2026.214754","url":null,"abstract":"<div><div>Neurological disorders represent a devastating global health crisis, and the blood-brain barrier (BBB) remains a major obstacle for their treatment. Conventional strategies for BBB opening, including direct intracranial injection, osmotic disruption, receptor-mediated transcytosis, and nanoparticle carriers, often suffers from surgical invasiveness, systemic toxicity, poor biodistribution, and off-target effects. Ultrasound-mediated drug delivery has emerged as a revolutionary non-invasive technology for transient and targeted BBB opening, enabling enhanced penetration of therapeutic agents into the central nervous system. This review comprehensively summarizes the mechanisms underlying ultrasound-based delivery with focus on current delivery platforms including microbubble (MB)-assisted, nanoparticle-based, and MB-nanoparticle composite strategies. Furthermore, we highlight recent advances in the application of focused ultrasound (FUS) combined with MBs for the treatment of Alzheimer's disease, Parkinson's disease, and glioma. Finally, we discuss emerging technologies such as sonodynamic therapy and ultrasound-controlled magnetic nanorobots, while also addressing current challenges in this field. This review underscores the transformative potential of ultrasound-mediated drug delivery as a versatile platform for precision neurology. It also prospects future directions for advancing multidisciplinary research and clinical translation.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214754"},"PeriodicalIF":6.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.bioadv.2026.214742
Xianggang Wang , Pan Li , Mohammad Nour Muselmani , Peng Gu , Xinzhan Mao , Tao Xiao , Hui Li
Serious injury to the growth plate often leads to bony bridge formation, resulting in halted long bone growth, angular deformities, and limb length discrepancies. These problems persist unaddressed in the clinic. In this study, we engineered a four-layered growth plate organoid by integrating three-dimensional culture with layer-specific induction techniques. A gelatin/alginate hydrogel scaffold was utilized to recapitulate the architecture of the native growth plate. In the three cartilage zones, bone marrow derived mesenchymal stem cells (BMSCs) and chondrocytes were co-cultured at a 3:1 ratio and directed toward chondrogenesis with gradient concentrations of TGF-β3, resulting in cartilage tissue similar to the native growth plate. In the calcified zone, BMP-2 directed BMSCs toward mineralization. Scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) were used to examine the microstructure of the gelatin/alginate hydrogel. Cell-based assays further confirmed the biocompatibility of the 3D culture system. A series of chondrogenic and osteogenic assays validated the successful formation of the organoid. In conclusion, by emulating the growth plate's distinct four-layered organization within a stratified hydrogel and applying targeted differentiation cues, we have established a highly biomimetic in vitro growth plate organoid. This model offers a novel platform for studying growth plate mechanisms and developing potential therapeutic strategies.
{"title":"Construction of growth plate organoids via a layered induction based in vitro 3D cultivation system","authors":"Xianggang Wang , Pan Li , Mohammad Nour Muselmani , Peng Gu , Xinzhan Mao , Tao Xiao , Hui Li","doi":"10.1016/j.bioadv.2026.214742","DOIUrl":"10.1016/j.bioadv.2026.214742","url":null,"abstract":"<div><div>Serious injury to the growth plate often leads to bony bridge formation, resulting in halted long bone growth, angular deformities, and limb length discrepancies. These problems persist unaddressed in the clinic. In this study, we engineered a four-layered growth plate organoid by integrating three-dimensional culture with layer-specific induction techniques. A gelatin/alginate hydrogel scaffold was utilized to recapitulate the architecture of the native growth plate. In the three cartilage zones, bone marrow derived mesenchymal stem cells (BMSCs) and chondrocytes were co-cultured at a 3:1 ratio and directed toward chondrogenesis with gradient concentrations of TGF-β3, resulting in cartilage tissue similar to the native growth plate. In the calcified zone, BMP-2 directed BMSCs toward mineralization. Scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) were used to examine the microstructure of the gelatin/alginate hydrogel. Cell-based assays further confirmed the biocompatibility of the 3D culture system. A series of chondrogenic and osteogenic assays validated the successful formation of the organoid. In conclusion, by emulating the growth plate's distinct four-layered organization within a stratified hydrogel and applying targeted differentiation cues, we have established a highly biomimetic in vitro growth plate organoid. This model offers a novel platform for studying growth plate mechanisms and developing potential therapeutic strategies.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214742"},"PeriodicalIF":6.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.bioadv.2026.214735
Mohammad Suhaan Dar , Niroj Kumar Sahu
Designing multifunctional hydrogels that combine structural tunability with therapeutic responsiveness remains a key challenge in translational cancer nanomedicine. Here, we report the development of a GelMA–Fe–GQDs nanocomposite hydrogel engineered for 3D bioprintability and magnetically triggered hyperthermia. Physicochemical characterization confirmed controlled swelling (310 ± 28%) and enzymatic stability, with rheological testing revealing reinforced viscoelasticity and partial recovery (∼17.2 ± 6%) after high-strain disruption. The hydrogel exhibited ideal printability, producing stable filaments and droplets with consistent deposition fidelity. Under an alternating magnetic field (AMF) 313 kHz, ∼18 kA·m−1, GelMA–Fe–GQDs hydrogels exhibited concentration-dependent heating, surpassing the therapeutic hyperthermia threshold (>42 °C) within 10 min at 1–2 mg·mL−1, with a calculated specific absorption rate (SAR) of ∼175 W·g−1 of Fe₃O₄. Thermal imaging confirmed uniform and localized heating within composite-containing regions. In vitro assays with triple negative breast cancer cells (TNBC) revealed high initial viability in both 2D and 3D cultures, with effective thermal ablation observed upon AMF exposure, validating the cytotoxic efficacy of magnetically induced heating. Collectively, these results establish GelMA–Fe–GQDs hydrogel as a printable, mechanically tunable, and magneto-responsive platform with potential for integration into 3D tumor models and localized cancer hyperthermia therapy.
{"title":"3D-printed GelMA-Fe-GQD magneto-hydrogel as a smart platform for triple-negative breast cancer hyperthermia","authors":"Mohammad Suhaan Dar , Niroj Kumar Sahu","doi":"10.1016/j.bioadv.2026.214735","DOIUrl":"10.1016/j.bioadv.2026.214735","url":null,"abstract":"<div><div>Designing multifunctional hydrogels that combine structural tunability with therapeutic responsiveness remains a key challenge in translational cancer nanomedicine. Here, we report the development of a GelMA–Fe–GQDs nanocomposite hydrogel engineered for 3D bioprintability and magnetically triggered hyperthermia. Physicochemical characterization confirmed controlled swelling (310 ± 28%) and enzymatic stability, with rheological testing revealing reinforced viscoelasticity and partial recovery (∼17.2 ± 6%) after high-strain disruption. The hydrogel exhibited ideal printability, producing stable filaments and droplets with consistent deposition fidelity. Under an alternating magnetic field (AMF) 313 kHz, ∼18 kA·m<sup>−1</sup>, GelMA–Fe–GQDs hydrogels exhibited concentration-dependent heating, surpassing the therapeutic hyperthermia threshold (>42 °C) within 10 min at 1–2 mg·mL<sup>−1</sup>, with a calculated specific absorption rate (SAR) of ∼175 W·g<sup>−1</sup> of Fe₃O₄. Thermal imaging confirmed uniform and localized heating within composite-containing regions. <em>In vitro</em> assays with triple negative breast cancer cells (TNBC) revealed high initial viability in both 2D and 3D cultures, with effective thermal ablation observed upon AMF exposure, validating the cytotoxic efficacy of magnetically induced heating. Collectively, these results establish GelMA–Fe–GQDs hydrogel as a printable, mechanically tunable, and magneto-responsive platform with potential for integration into 3D tumor models and localized cancer hyperthermia therapy.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214735"},"PeriodicalIF":6.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.bioadv.2026.214757
Yajun Chen , Xue Guo , Yuxin Zhang , Zhenming Yang , Jinmin Meng , Peiying Li , Yeyan Ni , Zijuan Huang , Huiying Wu , Qufu Wei
Plant polyphenol-based hydrogels have gained widespread attention due to their unique and outstanding properties such as adhesion, antibacterial, self-healing and biocompatibility. The adhesion performance of these hydrogels can be systematically engineered to meet specific requirements, demonstrating significant potential in biomedical applications. This review initially explores the design strategies of hydrogels derived from different plant polyphenols. Subsequently, the multiple adhesive properties imparted by diverse design strategies, including dry adhesion, underwater adhesion, switchable adhesion, specific adhesion and asymmetrical adhesion are discussed. In addition, biomedical applications of plant polyphenol-based adhesive hydrogels, focusing on wound dressings, therapeutic drug delivery, cartilage tissue scaffolds and wearable electronics are summarized. In the end, remaining challenges and outline prospects for future research are discussed. It is hoped that this review can provide new innovation into the development of plant polyphenol-based adhesive hydrogels.
{"title":"Recent advances in plant polyphenol-based adhesive hydrogels for biomedical applications","authors":"Yajun Chen , Xue Guo , Yuxin Zhang , Zhenming Yang , Jinmin Meng , Peiying Li , Yeyan Ni , Zijuan Huang , Huiying Wu , Qufu Wei","doi":"10.1016/j.bioadv.2026.214757","DOIUrl":"10.1016/j.bioadv.2026.214757","url":null,"abstract":"<div><div>Plant polyphenol-based hydrogels have gained widespread attention due to their unique and outstanding properties such as adhesion, antibacterial, self-healing and biocompatibility. The adhesion performance of these hydrogels can be systematically engineered to meet specific requirements, demonstrating significant potential in biomedical applications. This review initially explores the design strategies of hydrogels derived from different plant polyphenols. Subsequently, the multiple adhesive properties imparted by diverse design strategies, including dry adhesion, underwater adhesion, switchable adhesion, specific adhesion and asymmetrical adhesion are discussed. In addition, biomedical applications of plant polyphenol-based adhesive hydrogels, focusing on wound dressings, therapeutic drug delivery, cartilage tissue scaffolds and wearable electronics are summarized. In the end, remaining challenges and outline prospects for future research are discussed. It is hoped that this review can provide new innovation into the development of plant polyphenol-based adhesive hydrogels.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214757"},"PeriodicalIF":6.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1016/j.bioadv.2026.214759
Zijian Wang , Rui Yu , Ying Zhou , Jieying Zhang , Jiayi Yang , Huiwen Wang , Anzhi Wang , Wei Jin , Xinkun Shen , Caiyun Mu , Maowen Chen
Poor implant-bone integration under osteoporotic conditions remains a critical clinical challenge. The osteoporotic microenvironment, characterized by excessive oxidative stress, immune homeostasis imbalance, and persistent chronic inflammation, significantly impedes bone regeneration. To address this issue, we fabricated a multifunctional bioactive coating on the surface of Ti implants, integrating antioxidant, immunomodulatory, and osteogenic properties. In this study, we synthesized an in-situ lanthanum oxide (La2O3) nanoparticle coating (denoted as AT/La2O3) on the surface of titanium implants using hydrothermal and high-temperature calcination techniques. Subsequently, regaloside A (RA), a bioactive compound with therapeutic potential, was loaded onto the coating via an impregnation method to obtain AT/La2O3/RA. The composite coating demonstrated sustained and stable release of both RA and La3+ ions. Meanwhile, AT/La2O3/RA exhibited good reactive oxygen species (ROS) scavenging capability. Furthermore, it significantly promoted macrophage polarization toward the M2 phenotype, upregulating anti-inflammatory cytokines (IL-4RA and IL-10) while downregulating pro-inflammatory mediators (TNF-α and MMP2), thereby mitigating chronic inflammation. In addition, the coating markedly enhanced the proliferation and osteogenic differentiation of MSCs. Furthermore, in vivo evaluations showed that AT/La2O3/RA could effectively attenuated oxidative stress and suppressed inflammatory responses, ultimately fostering robust osseointegration. These findings highlight the potential of AT/La2O3/RA as a promising surface modification strategy to improve implant performance in the clinics.
{"title":"A nanoengineered coating with dual antioxidant and immunomodulatory functions on titanium implants for osteoregeneration in osteoporosis","authors":"Zijian Wang , Rui Yu , Ying Zhou , Jieying Zhang , Jiayi Yang , Huiwen Wang , Anzhi Wang , Wei Jin , Xinkun Shen , Caiyun Mu , Maowen Chen","doi":"10.1016/j.bioadv.2026.214759","DOIUrl":"10.1016/j.bioadv.2026.214759","url":null,"abstract":"<div><div>Poor implant-bone integration under osteoporotic conditions remains a critical clinical challenge. The osteoporotic microenvironment, characterized by excessive oxidative stress, immune homeostasis imbalance, and persistent chronic inflammation, significantly impedes bone regeneration. To address this issue, we fabricated a multifunctional bioactive coating on the surface of Ti implants, integrating antioxidant, immunomodulatory, and osteogenic properties. In this study, we synthesized an <em>in-situ</em> lanthanum oxide (La<sub>2</sub>O<sub>3</sub>) nanoparticle coating (denoted as AT/La<sub>2</sub>O<sub>3</sub>) on the surface of titanium implants using hydrothermal and high-temperature calcination techniques. Subsequently, regaloside A (RA), a bioactive compound with therapeutic potential, was loaded onto the coating <em>via</em> an impregnation method to obtain AT/La<sub>2</sub>O<sub>3</sub>/RA. The composite coating demonstrated sustained and stable release of both RA and La<sup>3+</sup> ions. Meanwhile, AT/La<sub>2</sub>O<sub>3</sub>/RA exhibited good reactive oxygen species (ROS) scavenging capability. Furthermore, it significantly promoted macrophage polarization toward the M2 phenotype, upregulating anti-inflammatory cytokines (IL-4RA and IL-10) while downregulating pro-inflammatory mediators (TNF-α and MMP2), thereby mitigating chronic inflammation. In addition, the coating markedly enhanced the proliferation and osteogenic differentiation of MSCs. Furthermore, <em>in vivo</em> evaluations showed that AT/La<sub>2</sub>O<sub>3</sub>/RA could effectively attenuated oxidative stress and suppressed inflammatory responses, ultimately fostering robust osseointegration. These findings highlight the potential of AT/La<sub>2</sub>O<sub>3</sub>/RA as a promising surface modification strategy to improve implant performance in the clinics.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214759"},"PeriodicalIF":6.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1016/j.bioadv.2026.214758
Jan Saip Aunan-Diop , Ancuta Ioana Friismose , Emi Hojo , Ziying Yin , Bo Halle , Frederik Harbo , Bo Mussmann , Frantz Rom Poulsen
Brain tumors alter the viscoelastic equilibrium of surrounding tissue, but how these changes shape the mechanics of tumor–brain coupling remains unclear. This study introduces mechanical instability mapping, a voxelwise measure of imbalance between elastic storage and viscous dissipation derived from magnetic resonance elastography (MRE). Twenty-eight patients (15 meningiomas, 13 glioblastomas) were analyzed using standardized 3 T MRE and tumor segmentation. Quantitative descriptors of instability topology—including skeleton length and branch-point densities, and radial persistence (radial-AUC)—were compared across WHO I, WHO II, and glioblastoma groups. Glioblastomas showed diffuse, branched instability fields with significantly higher skeleton and branch-point densities and lower radial-AUC compared with WHO I meningiomas, which exhibited compact, radially coherent patterns. Group-average probability maps indicated a transition from coherent to fragmented instability with increasing malignancy. These findings demonstrate that peritumoral mechanical topology reflects the degree of viscoelastic coupling at the tumor–brain interface. Instability mapping thereby extends conventional stiffness-based MRE metrics, offering a quantitative framework for assessing interface integrity and heterogeneity that may aid in elasticity-guided treatment strategies and biomechanical phenotyping of brain tumors.
{"title":"Mechanical instability as a signature of viscoelastic decoupling at the tumor–brain interface","authors":"Jan Saip Aunan-Diop , Ancuta Ioana Friismose , Emi Hojo , Ziying Yin , Bo Halle , Frederik Harbo , Bo Mussmann , Frantz Rom Poulsen","doi":"10.1016/j.bioadv.2026.214758","DOIUrl":"10.1016/j.bioadv.2026.214758","url":null,"abstract":"<div><div>Brain tumors alter the viscoelastic equilibrium of surrounding tissue, but how these changes shape the mechanics of tumor–brain coupling remains unclear. This study introduces mechanical instability mapping, a voxelwise measure of imbalance between elastic storage and viscous dissipation derived from magnetic resonance elastography (MRE). Twenty-eight patients (15 meningiomas, 13 glioblastomas) were analyzed using standardized 3 T MRE and tumor segmentation. Quantitative descriptors of instability topology—including skeleton length and branch-point densities, and radial persistence (radial-AUC)—were compared across WHO I, WHO II, and glioblastoma groups. Glioblastomas showed diffuse, branched instability fields with significantly higher skeleton and branch-point densities and lower radial-AUC compared with WHO I meningiomas, which exhibited compact, radially coherent patterns. Group-average probability maps indicated a transition from coherent to fragmented instability with increasing malignancy. These findings demonstrate that peritumoral mechanical topology reflects the degree of viscoelastic coupling at the tumor–brain interface. Instability mapping thereby extends conventional stiffness-based MRE metrics, offering a quantitative framework for assessing interface integrity and heterogeneity that may aid in elasticity-guided treatment strategies and biomechanical phenotyping of brain tumors.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214758"},"PeriodicalIF":6.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.bioadv.2026.214737
Xiaole Yin , Baowen Dong , Yimei Zhang , Liqun Wei , Nan Meng , Jianying Lin , Weihong Zhao , Min Xu , Jingxiu Bi , Zhihuan Zhao
Developing multifunctional nanoplatforms for synergistic tumor therapy remains a significant challenge. Here, we report a metal-free bio-nanozyme (SL-BN) derived from the natural medicinal plant Solanum lyratum (SL) via a facile two-step solvothermal and carbonization method. The as-prepared SL-BN integrates triple-enzyme-like (peroxidase, oxidase, and catalase) activities with robust photothermal conversion capabilities across both near-infrared (NIR)-I and -II bio-windows. Within the tumor microenvironment, SL-BN initiates a cascaded catalytic reaction: its catalase-like activity decomposes endogenous H2O2 to self-supply O2, thereby relieving hypoxia. This oxygen replenishment, in turn, fuels the oxidase-like activities to generate cytotoxic reactive oxygen species (ROS), creating a positive feedback loop for enzyme dynamic therapy (EDT). Crucially, upon NIR laser irradiation, the localized hyperthermia not only provides direct tumor ablation via photothermal therapy (PTT) but also significantly accelerates these enzymatic reaction rates. This photothermally self-enhanced synergistic strategy resulted in a tumor regression of 98.04% and 99.58% based on tumor volume and weight, respectively. This study presents a novel strategy for designing multifunctional bio-nanozymes from natural biomass and highlights the potential of integrating self-sustaining catalytic cycles with photothermal enhancement for highly effective tumor therapy.
{"title":"Solanum lyratum-derived metal-free bio-nanozyme for photothermally self-enhanced cascade catalytic synergistic tumor therapy","authors":"Xiaole Yin , Baowen Dong , Yimei Zhang , Liqun Wei , Nan Meng , Jianying Lin , Weihong Zhao , Min Xu , Jingxiu Bi , Zhihuan Zhao","doi":"10.1016/j.bioadv.2026.214737","DOIUrl":"10.1016/j.bioadv.2026.214737","url":null,"abstract":"<div><div>Developing multifunctional nanoplatforms for synergistic tumor therapy remains a significant challenge. Here, we report a metal-free bio-nanozyme (SL-BN) derived from the natural medicinal plant <em>Solanum lyratum</em> (SL) via a facile two-step solvothermal and carbonization method. The as-prepared SL-BN integrates triple-enzyme-like (peroxidase, oxidase, and catalase) activities with robust photothermal conversion capabilities across both near-infrared (NIR)-I and -II bio-windows. Within the tumor microenvironment, SL-BN initiates a cascaded catalytic reaction: its catalase-like activity decomposes endogenous H<sub>2</sub>O<sub>2</sub> to self-supply O<sub>2</sub>, thereby relieving hypoxia. This oxygen replenishment, in turn, fuels the oxidase-like activities to generate cytotoxic reactive oxygen species (ROS), creating a positive feedback loop for enzyme dynamic therapy (EDT). Crucially, upon NIR laser irradiation, the localized hyperthermia not only provides direct tumor ablation via photothermal therapy (PTT) but also significantly accelerates these enzymatic reaction rates. This photothermally self-enhanced synergistic strategy resulted in a tumor regression of 98.04% and 99.58% based on tumor volume and weight, respectively. This study presents a novel strategy for designing multifunctional bio-nanozymes from natural biomass and highlights the potential of integrating self-sustaining catalytic cycles with photothermal enhancement for highly effective tumor therapy.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214737"},"PeriodicalIF":6.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1016/j.bioadv.2026.214756
Luis F.O. Silva
{"title":"Technical discussion on the methodological and interpretative aspects of “mineralized extracellular matrix composite scaffold incorporated with salvianolic acid a enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration”","authors":"Luis F.O. Silva","doi":"10.1016/j.bioadv.2026.214756","DOIUrl":"10.1016/j.bioadv.2026.214756","url":null,"abstract":"","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214756"},"PeriodicalIF":6.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1016/j.bioadv.2026.214753
Mario García-González , Francisco Vidal-Negreira , Antonio González-Cantalapiedra , Rui L. Reis , Tiago H. Silva
The rising demand for safe and effective alternatives for bone regeneration has spurred extensive research into biomaterials derived from marine collagen. This systematic review aimed to evaluate the feasibility of marine collagen-based compounds and derived constructs for bone regeneration in in vivo preclinical models while critically assessing the methodological quality of the included studies. The review was conducted following PRISMA guidelines, utilizing the PICO framework to delineate the scope and research focus. After applying predefined inclusion and exclusion criteria, a comprehensive search across multiple databases identified 15 eligible studies. Methodological quality was appraised using the ARRIVE 2.0 guidelines, and the risk of bias was weighed through the SYRCLE tool. The selected studies evaluated collagens derived from fish and marine sponges, which were processed into scaffolds, membranes, and hydrogels. These biomaterials exhibited notable biocompatibility, osteoconductivity, and efficacy in promoting new bone formation. Furthermore, synergistic combinations with hydroxyapatite, chitosan, and growth factors such as BMP-2 significantly enhanced their regenerative capacity. However, several critical shortcomings were observed in experimental designs, including inadequate randomization, absence of blinding, and insufficient reporting of animal handling protocols. These limitations raise concerns regarding reproducibility and the overall validity of the findings. In conclusion, marine collagen-based biomaterials hold significant potential for bone regeneration applications. Nevertheless, achieving greater standardization and methodological rigor in preclinical research is paramount to ensuring their successful clinical translation.
{"title":"Use of collagen from marine origin for bone tissue regeneration in preclinical in vivo studies: a systematic review and quality evaluation","authors":"Mario García-González , Francisco Vidal-Negreira , Antonio González-Cantalapiedra , Rui L. Reis , Tiago H. Silva","doi":"10.1016/j.bioadv.2026.214753","DOIUrl":"10.1016/j.bioadv.2026.214753","url":null,"abstract":"<div><div>The rising demand for safe and effective alternatives for bone regeneration has spurred extensive research into biomaterials derived from marine collagen. This systematic review aimed to evaluate the feasibility of marine collagen-based compounds and derived constructs for bone regeneration in <em>in vivo</em> preclinical models while critically assessing the methodological quality of the included studies. The review was conducted following PRISMA guidelines, utilizing the PICO framework to delineate the scope and research focus. After applying predefined inclusion and exclusion criteria, a comprehensive search across multiple databases identified 15 eligible studies. Methodological quality was appraised using the ARRIVE 2.0 guidelines, and the risk of bias was weighed through the SYRCLE tool. The selected studies evaluated collagens derived from fish and marine sponges, which were processed into scaffolds, membranes, and hydrogels. These biomaterials exhibited notable biocompatibility, osteoconductivity, and efficacy in promoting new bone formation. Furthermore, synergistic combinations with hydroxyapatite, chitosan, and growth factors such as BMP-2 significantly enhanced their regenerative capacity. However, several critical shortcomings were observed in experimental designs, including inadequate randomization, absence of blinding, and insufficient reporting of animal handling protocols. These limitations raise concerns regarding reproducibility and the overall validity of the findings. In conclusion, marine collagen-based biomaterials hold significant potential for bone regeneration applications. Nevertheless, achieving greater standardization and methodological rigor in preclinical research is paramount to ensuring their successful clinical translation.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214753"},"PeriodicalIF":6.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1016/j.bioadv.2026.214752
Xin Chen , Song Chen , Yi Hou
Periodontitis is caused by dental plaque that triggers the host immune responses by the dysregulation of reactive oxygen species (ROS), leading to the destruction of local tissues such as gingiva, periodontal ligament, and alveolar bone. With its high prevalence, periodontitis impacts the oral health of billions worldwide. Clinical therapy for periodontitis relies on mechanical debridement and adjunctive antibiotics, strategies that often result in incomplete efficacy and a high recurrence rate. The development of cerium oxide nanoparticles (nanoceria), which exhibits enzyme-like catalytic activity and biocompatibility, enables targeted redox modulation to restore ROS balance, showing promise for clinical treatment. Based on above, this article focuses on the pathogenesis of periodontitis and the regulatory functions of ROS, and summarizes the design principles, functional engineering, and therapeutic mechanisms of nanoceria for periodontal therapy. Furthermore, the review outlines preventive strategies against periodontitis based on nanoceria. It then discusses the associated clinical challenges and future prospects. Overall, this work provides a comprehensive overview of nanoceria as the redox-based strategy for periodontal management.
{"title":"Nanoceria-mediated redox modulation for periodontal management: Mechanisms, applications, and challenges","authors":"Xin Chen , Song Chen , Yi Hou","doi":"10.1016/j.bioadv.2026.214752","DOIUrl":"10.1016/j.bioadv.2026.214752","url":null,"abstract":"<div><div>Periodontitis is caused by dental plaque that triggers the host immune responses by the dysregulation of reactive oxygen species (ROS), leading to the destruction of local tissues such as gingiva, periodontal ligament, and alveolar bone. With its high prevalence, periodontitis impacts the oral health of billions worldwide. Clinical therapy for periodontitis relies on mechanical debridement and adjunctive antibiotics, strategies that often result in incomplete efficacy and a high recurrence rate. The development of cerium oxide nanoparticles (nanoceria), which exhibits enzyme-like catalytic activity and biocompatibility, enables targeted redox modulation to restore ROS balance, showing promise for clinical treatment. Based on above, this article focuses on the pathogenesis of periodontitis and the regulatory functions of ROS, and summarizes the design principles, functional engineering, and therapeutic mechanisms of nanoceria for periodontal therapy. Furthermore, the review outlines preventive strategies against periodontitis based on nanoceria. It then discusses the associated clinical challenges and future prospects. Overall, this work provides a comprehensive overview of nanoceria as the redox-based strategy for periodontal management.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"183 ","pages":"Article 214752"},"PeriodicalIF":6.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号