Noropsikiyatri Arsivi-Archives of Neuropsychiatry最新文献

Introduction: This study aimed to conduct the Turkish adaptation, validity, and reliability analyses of the Children and Adolescent Behavior Inventory (CABI) Family Questionnaire.

Method: A total of 1015 parents of children and adolescents aged 6-14 years, with 762 from the community sample and 253 from the clinical sample, participated in the study. After the language adaptation of the scale was completed by experts, its construct validity was determined using exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and discriminant validity. The reliability was assessed with Cronbach's alpha internal consistency coefficients, and the test-retest reliability of the scale was tested on 100 participants.

Results: The results of the EFA showed that the scale had 10 factors. The items associated with the 10th factor, which was different from the original scale, aligned with the subscales of the Sluggish Cognitive Tempo. The results of the CFA indicated that the factor load values were statistically significant, and the fit index values were at moderate, good, and excellent levels. A comparison of the subscale scores of the clinical and population sample groups showed that the scale had a distinctive feature. The Cronbach's alpha value of the total scale score was calculated to be 0.94. No statistically significant difference was found between the mean test-retest scores obtained on the subscales. The test-retest correlation coefficient was found to be within the range of r=0.605-0.853 for the subscales (p<0.01).

Conclusion: This study proved that the CABI Family Questionnaire was a valid and reliable scale and could be administered to the parents of Turkish children and adolescents aged between six and 14 years in population and clinical samples.

Introduction: Bipolar disorder (BD) and borderline personality disorder (BPD) are often indistinguishable, given both the key features of impulsivity and emotional dysregulation. This indicates widespread comorbidity and potential misdiagnosis in both groups. Therefore, this study aimed to differentiate BD and BPD by using alterations of brain hemodynamics under the influence of executive tests.

Methods: Twenty patients with the euthymic phase of BD and 20 patients with BPD, and 20 healthy control subjects were included in this study. The prefrontal cortex (PFC) hemodynamic responses were evaluated using functional near-infrared spectroscopy (fNIRS) during the Stroop Test and Wisconsin Card Sorting Test (WCST).

Results: Left dorsolateral prefrontal cortex (DLPFC) activation was significantly decreased in BPD during both tests. On the other hand, the BD group showed medial PFC hypoactivation during both tests, and this finding is distinct from BPD (p<0.05).

Conclusion: Our results indicate that brain hemodynamics during the executive test can highlight differences between BP and BPD. While medial PFC hypoactivation was more prominent in the BP group, DLPFC hypoactivation was more pronounced in the BPD group.

Introduction: Cognitive impairment often occurs secondary to epilepsy. This study aims to evaluate the cognitive functions of patients with idiopathic generalized epilepsy (IGE) by using the digital neuropsychological assessment.

Methods: Seventy-nine patients diagnosed with IGE in the last 10 years in our clinic, who completed at least eight years of education were recruited. Participants who met the criteria were 36 individuals with IGE syndrome as well as 36 healthy individuals between the ages of 18-48. All volunteer participants were administered the standardized mini mental test (SMMT) and the Beck depression scale (BDS). For the neurocognitive assessment, participants completed five tasks in TestMyBrain digital neuropsychology test battery (TMB) which are TMB digit span, TMB choice reaction time test, TMB visual paired associates test, TMB matrix reasoning, and TMB digit symbol matching assessing a variety of cognitive domains.

Results: IGE patients showed lower cognitive performance in attention, short-term memory, working memory, visual memory, episodic memory, cognitive processing speed, response selection/inhibition, fluid cognitive ability, and perceptual reasoning domains. The results show that IGE patients have cognitive dysfunction in many cognitive domains.

Conclusion: IGE patients performed significantly worse outcomes in some tests of the TMB. In this study, it is aimed to emphasize the necessity of evaluating the cognitive aspects of epilepsy patients, which will be of great importance in their functionality, in addition to providing symptomatic treatment in order to control their seizures.

Introduction: The effect of Ginkgo biloba (GB) on mitochondria-dependent TRPV1 ion channels in neuroblastoma cells was investigated by creating an Alzheimer's disease (AD) model.

Methods: Okadaic acid was applied on SH-SY5Y cells to create an AD model. After cellular differentiation, the study was organized with the seven main groups, examining the effect of GB on calcium depended TRPV1 channels in neuroblastoma cells AD, has been established in vitro.

Results: The higher Ca²+ concentration was detected in the GB+AD, AD and AD+GB groups when compared with the control (p<0.001). The Ca²+ level was lower in GB+AD and AD+GB groups than in the AD group (p<0.001). Also, cytosolic Ca²+ concentration was lower in the GB+AD than in the AD+GB group (p<0.05), the apoptosis and intracellular reactive oxygen species (ROS) values were higher in the GB+AD, AD and AD+GB groups than in the control (p<0.001). The apoptosis and intracellular ROS values were higher in AD group than in the GB+AD and AD+GB group (p<0.001) and the apoptosis level was higher in AD+GB group than GB+AD group (p<0.001) and the mitochondrial depolarization, caspase 3 and caspase 9 levels were higher in the GB+AD, AD and AD+GB groups when compared to the control group (p<0.001). Also, the values were lower in the GB+AD group, AD group and AD+GB groups when compared with the GB+AD+capsazepine group, AD+capsazepine group and AD+GB+capsazepine respectively (p<0.001).

Conclusion: These results show us that GB has a protective effect besides its therapeutic effect in Alzheimer's disease via TRPV1 channel.

Introduction: Mesencephalic hemorrhage (MH) is a rare presentation of spontaneous intraparenchymal hemorrhage. This study aims to evaluate prognostic parameters of the MH outcome.

Methods: We conducted an extensive search in the literature for cases with spontaneous, isolated mesencephalic hemorrhage. The study was conducted according to the statement of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Sixty-two eligible cases have been reported in the literature as proven by CT or MRI, and to these, we added six cases confirmed by MRI. The modified Rankin Scale (mRS) was dichotomized into two groups as the favorable outcome (FO; score, 0-2) and unfavorable outcome (UO; score, 3-6).

Results: Of the 68 patients studied, 26 (38%) presented with normal consciousness, 22 (32%) with lethargy , and 20 (29%) with stupor or coma. There was no cause of hemorrhage in 26 (65%) patients with FO and 12 (43%) with UO (p=0.059). In univariate analyses, neither arteriovenous malformations (p=0.33) nor cavernomas (p=0.19) were associated with outcome. Multiple logistic regression analysis revealed that hypertension (OR, 51.22; CI95%, 1.92-1370.24; P=0.019), consciousness (OR, 133.54; CI95%, 1.61-1113.3; P=0.03), NIHSS at admission (OR, 57.23; CI95%, 2.87-1141.2; p=0.008), and ventrodorsal hemorrhage size (≥1 cm) (OR, 61.83; CI95%, 2.15-1779.2; p=0.016) were significantly associated with UO. Three months after stroke, 40 patients (59%) had FO, 28 (41%) had UO, and 8 (12%) died.

Conclusion: These results suggest that ventrodorsal size of hemorrhage and clinical severity at stroke onset are possible predictors of functional outcome after mesencephalic hemorrhage.

Introduction: This study aimed to demonstrate the validity of the Ask Suicide-Screening Questions (ASQ) in a clinical sample consisting of adolescents admitted to child and adolescent psychiatry (CAP), and then to confirm its validation in those presenting to the pediatric emergency department (PED), which was the main target group for the study.

Method: This cross-sectional study evaluated the compatibility of the ASQ with the suicide probability scale, which is a standardized measure, to identify cases with suicide risk in 248 adolescents aged 10-18 years. To demonstrate the clinical validity of the scale, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), negative likelihood ratio (NLR), Kappa, and area under the curve (AUC) performance metrics and 95% confidence interval (CI) values were calculated.

Results: Positive screening rate, sensitivity, specificity, PPV and NPV for the CAP patients were calculated as 31.8%, 100% (95% CI: 100.0-100.0), 70.9% (95% CI: 63.4-78.4), 12.8% (95% CI: 3.2-22.3) and 100% (95% CI: 100.0-100.0), respectively. The PLR and AUC were calculated as 3.4% (95% CI: 2.7-4.5) and 0.855 (95% CI: 0.817-0.892), respectively. Positive screening rate, sensitivity, specificity, PPV and NPV for the PED patients were calculated as 28%, 100% (95% CI: 100.0-100.0), 75.3% (95% CI: 66.3-84.2), 21.4% (95% CI: 6.2-36.6) and 100% (95% CI: 100.0-100.0), respectively. The PLR, Kappa and AUC were 4.05% (95% CI: 2.82-5.81), 0.278 and 0.876 (95% CI: 0.832-0.921), respectively.

Conclusion: This study showed the first evidence that Turkish adaptation of the ASQ is a valid screening tool for identifying those at risk of suicide among adolescents who applied to the CAP and PED.

Introduction: Depression which is one of the mood disorders, causes a decrease in the work that requires participation during the day, and affects interpersonal relationships. It is known to be a fairly common mental disorder, especially among women. The aim of this systematic review is to investigate the effect of women's employment status on the severity of depressive symptoms in Turkey.

Method: We searched the databases of YÖK Thesis Center, ULAKBIM, Web of Science and Scopus to detect those studies aiming to compare the employed women with housewives in terms of the depressive symptoms measured with validated self-report scales in Turkish.

Results: Of the 283 studies reported in Turkish or English as an article or dissertation, 10 met the inclusion criteria for meta-analysis. The random effects meta-analysis conducted with R 4.0.1, meta and metafor package revealed a slight and statistically nonsignificant effect of the employment status on women's depressive scores (g=-0.13 95% Confidence Interval [CI] [-0.41, 0.14]). Heterogeneity between studies was estimated at a high level (I2=90.3% 95% CI [84.3%, 94%]). Results of the meta-regression analyses implied that neither the sample size (R2=0.00%) nor the publication year (R2=5.58%) were among the main sources the heterogeneity. The findings suggest that the risk of having depressive symptoms is nearly same in employed women as in housewives.

Discussion: Hence, employment status is unlikely to be among the main factors leading to relatively higher prevalence of depression among women.