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Assessing Stress Level Scores Against Wearables-Driven Physiological Measurements. 根据可穿戴设备驱动的生理测量评估压力水平得分。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-12-01 DOI: 10.1002/smi.70125
Hadar Rosenbach, Alon Itzkovitch, Yori Gidron, Tom Schonberg

Daily stressors elicit physiological and mental responses impacting health, cognition, and behaviour. Accurately assessing psychological stress responses in natural settings remains challenging despite extensive research, though wrist-worn devices have the potential to address this gap through remote data collection. The Garmin fitness tracker provides a stress score largely based on HRV which must be validated prior to use in research. This study aimed to (1) predict psychological self-reported stress from physiological measurements and Garmin calculated stress score, and (2) assess the stress score given by the Garmin Vivosmart 4 against HR and HRV from ECG recordings derived by the Polar H10 chest strap. A pilot study of 29 participants was conducted, followed by power calculations and preregistration of the main study which included 60 participants. Data were collected simultaneously from both Garmin and Polar device during a laboratory session of restful and mental-stress-inducing tasks. Garmin's stress score, mean HR, SD2/SD1, and HF power exhibited significant differences between stress and rest conditions. Moreover, Garmin's stress score correlated significantly with HR, RMSSD, and SD2/SD1. However, out of our physiological measurements, heart rate showed the strongest association with self-reported stress, while the Garmin stress score demonstrated only marginal predictive value for subjective stress experience. Our findings also suggest that physiological responses to mental stress were influenced by sex and tonic HRV. The study suggests that the GSS, although even better heart rate, are indicative of mental stress. Garmin, with its accessibility and noninvasive nature, measures both heart rate and consumer health score (stress), promising widespread utilisation in various research domains.

日常压力源会引发影响健康、认知和行为的生理和心理反应。尽管进行了广泛的研究,但准确评估自然环境下的心理应激反应仍然具有挑战性,尽管腕带设备有可能通过远程数据收集来解决这一差距。Garmin健身追踪器提供的压力评分主要基于HRV,在用于研究之前必须进行验证。本研究旨在(1)通过生理测量和Garmin计算的压力评分预测心理自我报告的压力,(2)评估Garmin Vivosmart 4给出的压力评分与Polar H10胸带获得的心电图记录的HR和HRV。对29名参与者进行了初步研究,随后对包括60名参与者的主要研究进行了功率计算和预登记。在休息和精神压力诱导任务的实验室会话期间,同时从Garmin和Polar设备收集数据。应激与休息条件下Garmin应激评分、平均HR、SD2/SD1、HF功率均有显著性差异。Garmin’s应激评分与HR、RMSSD、SD2/SD1显著相关。然而,在我们的生理测量中,心率显示出与自我报告的压力最强的关联,而Garmin压力评分仅显示主观压力体验的边际预测价值。我们的研究结果还表明,对精神压力的生理反应受到性和滋补性HRV的影响。这项研究表明,虽然GSS的心率更高,但它表明了精神压力。Garmin具有可及性和非侵入性,可测量心率和消费者健康评分(压力),有望在各种研究领域得到广泛应用。
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引用次数: 0
Safeguarding Well-Being Under Exploitative Leaders: The Buffering Effects of Follower Strategies on Perceived Injustice. 剥削性领导下的福利保障:追随者策略对感知不公正的缓冲作用。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-12-01 DOI: 10.1002/smi.70127
Saleh Bajaba, Saad Basaad

This study examines the impact of exploitative leadership (EL) on employees' workplace well-being (WWB), elucidating underlying mechanisms and mitigating factors. Grounded in Conservation of Resources (COR) theory, the Job Demands-Resources (JD-R) model, and the Transactional Theory of Stress (TTS), we explore the mediating role of interactional injustice (IIJ) in the EL-WWB relationship and the moderating effect of managing-your-boss (MYB) strategies. Using a two-wave time-lagged design, data were collected from 263 full-time U.S. employees and analysed via Partial Least Squares Structural Equation Modeling (PLS-SEM), supplemented by Importance-Performance Map Analysis (IPMA) and Necessary Condition Analysis (NCA). Results indicate that EL positively relates to IIJ, which in turn negatively affects WWB, establishing IIJ as a full mediator. MYB moderates the EL-IIJ link, weakening it at higher MYB levels, and extends this buffering to the conditional indirect pathway. IPMA underscores IIJ's high negative importance for WWB, while NCA reveals no necessary conditions but highlights MYB's enabling role. These findings advance destructive leadership research by emphasising follower agency in resource conservation and stress appraisal, offering practical insights for enhancing well-being through proactive strategies. Theoretical implications, limitations, and future research directions are discussed.

本研究探讨了剥削性领导对员工工作场所幸福感的影响,阐明了潜在的机制和缓解因素。基于资源保护理论(COR)、工作需求-资源模型(JD-R)和压力交易理论(TTS),我们探讨了互动不公平(IIJ)在员工工作与工作关系中的中介作用,以及“管你的老板”(MYB)策略的调节作用。采用双波滞后设计,从263名全职美国员工中收集数据,并通过偏最小二乘结构方程模型(PLS-SEM)进行分析,辅以重要性-绩效图分析(IPMA)和必要条件分析(NCA)。结果表明,EL与IIJ呈正相关,IIJ反过来负向影响WWB,表明IIJ是一个完全的中介。MYB调节EL-IIJ连接,在较高的MYB水平上削弱它,并将这种缓冲扩展到条件间接途径。IPMA强调了IIJ对WWB的高度负面重要性,而NCA没有揭示必要条件,但强调了MYB的促进作用。这些发现通过强调资源保护和压力评估中的追随者代理,推动了破坏性领导力研究,为通过主动策略提高幸福感提供了实际见解。讨论了理论意义、局限性和未来的研究方向。
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引用次数: 0
Between Vulnerability and Connection: Longitudinal Evidence on the Impact of Transformative Religious/Spiritual Experiences. 脆弱性与联系之间:宗教/精神变革经验影响的纵向证据
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70110
Zhuo Job Chen, Renae Wilkinson, Richard G Cowden

Transformative religious/spiritual experiences (RSE) represent a subset of extraordinary experiences that are both self-destabilizing and relational in nature. This double-edged quality positions transformative RSE as both a potential source of psychological vulnerability and a catalyst for enhanced social connectedness. This study investigates the antecedents and outcomes of transformative RSE using a nationally representative longitudinal sample of 10,529 young adults from the National Longitudinal Study of Adolescent to Adult Health T0 (1994-1995), T1 (2001-2002), and T2 (2008). We examined associations of reporting a transformative RSE at T1 (late adolescence) on a broad range of physical, mental, behavioural, and social health and wellbeing indicators assessed at T2 (early adulthood). Primary analyses controlled for an extensive set of covariates assessed at T0 (early adolescence), with sensitivity analyses employing both liberal (T0 sociodemographic characteristics only) and conservative (contemporaneous covariates taken from T1) adjustment strategies. Antecedents (T0 correlates) of transformative RSE included adverse childhood environments, negative parental dynamics, and heightened religious involvement. Consistent T2 outcomes of transformative RSE involved some markers of mental and social vulnerability (i.e., PTSD diagnosis and loneliness), as well as increased prosocial engagement (i.e., volunteering and voting). These findings support the theorized double-edged sword effect of transformative RSE and suggest the potential role of meaning-making and integration in shaping long-term psychological and social outcomes.

变革性的宗教/精神体验(RSE)代表了非凡体验的一个子集,这些体验既具有自我不稳定性,又具有关系性。这种双刃剑的特质使变革性RSE既是心理脆弱性的潜在来源,也是增强社会联系的催化剂。本研究利用全国青少年到成人健康纵向研究(1994-1995年)、T1(2001-2002年)和T2(2008年)中具有全国代表性的10529名年轻人的纵向样本,调查了变革性RSE的前因和结果。我们研究了在T1(青春期晚期)报告变革性RSE与T2(成年早期)评估的广泛的身体、心理、行为和社会健康和福祉指标之间的关联。初步分析控制了在T0(青春期早期)评估的大量协变量,敏感性分析采用了自由(T0社会人口统计学特征)和保守(来自T1的同期协变量)调整策略。变革性RSE的前因包括不良的童年环境、消极的父母动力和高度的宗教参与。变革性RSE的T2结果一致涉及心理和社会脆弱性的一些标志(即PTSD诊断和孤独感),以及增加的亲社会参与(即志愿服务和投票)。这些发现支持了变革性RSE的双刃剑效应理论,并表明意义制造和整合在形成长期心理和社会结果方面的潜在作用。
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引用次数: 0
The Fundamental Frequency of Voice as a Potential Stress Biomarker: A Systematic Review and Meta-Analysis. 语音基本频率作为潜在的应激生物标志物:系统回顾和荟萃分析。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70112
Diogo de Lacerda Veiga, Thales Marcon Almeida, Ricardo Riyoiti Uchida, Quirino Cordeiro

Stress alters vocal production, particularly by affecting laryngeal muscle function. Despite several studies on voice acoustics under stress, no systematic synthesis exists. This study aimed to conduct a systematic review and meta-analysis of experimental studies assessing the impact of stress on vocal fundamental frequency (F0). Following PRISMA guidelines, a systematic search was conducted in PubMed and Scopus databases for studies published between January 2010 and September 2024. Eligible studies included adult participants exposed to experimental or naturalistic stressors, with pre- and post-stress voice recordings analysed using objective acoustic measures. Data were extracted regarding F0, and random-effects meta-analyses were performed. Subgroup analyses were conducted based on gender, speech type, and stress induction method. Ten studies met the inclusion criteria, encompassing 1148 observations. The meta-analysis showed a significant increase in F0 after stress (SMD = 0.5504, 95% CI [0.3014, 0.7995], p < 0.001) with substantial heterogeneity (I2 = 69.2%). However, evidence of publication bias was observed; trim-and-fill attenuated the pooled estimate to a nonsignificant effect (SMD = 0.1710; 95% CI: -0.1472 to 0.4891; p = 0.2923). Subgroup analyses revealed stronger effects in women (SMD = 0.7128, 95% CI [0.3763, 1.0492], p < 0.001) and during spontaneous speech (SMD = 0.7911, 95% CI [0.4492, 1.1331], p < 0.001), with nonsignificant results for men and standardized speech. Effects tended to be larger for naturalistic stressors than validated laboratory procedures, though the between-group comparison was not statistically significant. F0 shows promise for stress assessment, but publication bias and heterogeneity warrant caution. F0 should be considered a noninvasive candidate biomarker requiring validation in large, prospective studies using standardized protocols and representative, gender-stratified cohorts.

压力会改变声音的产生,尤其是通过影响喉部肌肉的功能。尽管有一些关于压力下声声学的研究,但还没有系统的合成。本研究旨在对应激对声乐基频(F0)影响的实验研究进行系统回顾和meta分析。遵循PRISMA指南,在PubMed和Scopus数据库中对2010年1月至2024年9月间发表的研究进行了系统检索。符合条件的研究包括暴露于实验性或自然压力源的成年参与者,使用客观声学测量分析压力前和压力后的录音。提取有关F0的数据,并进行随机效应荟萃分析。根据性别、言语类型和应激诱导法进行分组分析。10项研究符合纳入标准,共纳入1148个观察值。meta分析显示应激后F0显著增加(SMD = 0.5504, 95% CI [0.3014, 0.7995], p 2 = 69.2%)。然而,观察到发表偏倚的证据;修整填充将合并估计降低到不显著的效果(SMD = 0.1710; 95% CI: -0.1472至0.4891;p = 0.2923)。亚组分析显示,女性的影响更大(SMD = 0.7128, 95% CI [0.3763, 1.0492], p
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引用次数: 0
Risks to the Unborn: An Umbrella Review on the Effects of Prenatal Maternal Stress Caused by Natural Disasters. 对未出生胎儿的风险:自然灾害引起的产前产妇压力影响的综述。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70108
Kaia A Bustnes, Sarah Schäfer, Linus Held, Hannah Wessels, Maximilian A Friehs

Traditionally, to promote an optimal pregnancy trajectory and child development, encompassing both physical and mental health, a preventative focus is crucial and - ideally - exposure to negative influences is supposed to be limited. However, when prevention is not feasible, early identification of developmental impairments is paramount to address potential risk factors for future development. Specifically, one source of developmental impairment is prenatal maternal stress. This umbrella review integrates and summarizes current research on the diverse developmental consequences of prenatal maternal stress caused by natural disasters. The cumulative evidence strongly suggests that the effect of maternal stress during pregnancy does not end after pregnancy but can lead to a wide range of detrimental effects on a child's development throughout the whole lifespan. By synthesizing previous empirical findings, the current review provides an overview about potential congenital developmental difficulties as well as the interdependence of these negative effects. The depicted results highlight a risk of overarching negative effects of prenatal stress for the child. It is stated that in order to prevent possible long-lasting effects this risk has to be effectively taken into account. Possible recommendations for prevention interventions are discussed.

传统上,为了促进最佳的怀孕轨迹和儿童发育,包括身体和心理健康,预防重点是至关重要的,理想情况下,应该限制接触负面影响。然而,当预防不可行时,早期识别发育障碍对于解决未来发展的潜在风险因素至关重要。具体来说,发育障碍的一个来源是产前母亲的压力。这篇综述整合和总结了目前关于自然灾害引起的产前产妇压力的各种发育后果的研究。越来越多的证据有力地表明,怀孕期间母亲压力的影响不会在怀孕后结束,但会对孩子的整个生命周期的发展产生广泛的有害影响。通过综合以往的实证研究结果,本综述概述了潜在的先天性发育困难以及这些负面影响的相互依赖性。所描述的结果突出了产前压力对孩子的总体负面影响的风险。有人指出,为了防止可能产生的长期影响,必须有效地考虑到这种风险。讨论了预防干预措施的可能建议。
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引用次数: 0
Perceived Work Dirtiness and Procrastination Among Frontline Healthcare Workers: The Moderating Role of Patient Relationship Attachment. 一线医护人员工作肮脏感与拖延:患者关系依恋的调节作用
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70111
Huajun Ma, Zimeng Chen, Xin Liu, Xinglin Liu, RuiHeng Han

In the healthcare sector, frontline healthcare workers often have to deal with tasks that are labelled as 'dirty work.' These tasks not only pose potential threats to their physical health but may also significantly impact their psychological state and work outcomes. Despite the critical nature of these issues, there is currently a relative scarcity of research in this area. Therefore, based on the cognitive appraisal theory of stress, we conducted a two-stage time-lagged questionnaire survey among frontline healthcare workers in three large hospitals in China. The analysis of 526 valid questionnaires revealed that the perception of dirty work among frontline medical staff has a positive impact on work procrastination, with avoidance motivation, approach motivation, and sense of work meaning playing a serial mediating role in this process, and patient attachment moderating this mediating effect. These findings not only provide a new perspective for understanding the psychological mechanisms behind the work procrastination behaviour of frontline healthcare workers but also lay the foundation for healthcare institutions, especially for those medical staff who are frequently in dirty work environments, to develop scientific, evidence-based intervention strategies.

在医疗保健部门,一线医护人员经常不得不处理被贴上“肮脏工作”标签的任务。这些任务不仅对他们的身体健康构成潜在威胁,而且可能对他们的心理状态和工作成果产生重大影响。尽管这些问题的关键性质,目前在这一领域的研究相对稀缺。因此,基于压力认知评价理论,我们对中国三家大型医院的一线医护人员进行了两阶段滞后问卷调查。通过对526份有效问卷的分析,发现一线医务人员肮脏工作感知对工作拖延有正向影响,其中回避动机、接近动机和工作意义感在此过程中起串行中介作用,患者依恋在此中介作用中起调节作用。这些发现不仅为了解一线医护人员工作拖延行为背后的心理机制提供了新的视角,也为医疗机构,特别是那些经常处于肮脏工作环境的医护人员制定科学、循证的干预策略奠定了基础。
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引用次数: 0
Examining the Between- and Within-Person Associations Between Psychological Stress and Physical Activity: A Random Intercept Cross-Lagged Panel Model. 心理压力与身体活动之间的人际关系:一个随机截距交叉滞后面板模型。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70114
Benjamin A Hives, Brook Hadwen, Leo McHegg, Mark R Beauchamp, Bruno D Zumbo, Eli Puterman

Physical activity is well-evidenced to reduce stress and health risks. Frequent or prolonged psychological stress increases the risk for physical and mental health morbidities. Further, high stress may also impair physical activity behaviours. Eight hundred adults (Mage = 41.47, SD = 13.61; % women = 47.5%) completed questionnaires at baseline, as well as one- and two-month follow-ups that were used to measure physical activity and psychological stress. A random intercept cross-lagged panel model was fit to explore the bidirectional, month-to-month associations between physical activity and psychological stress. There were significant between-person associations between psychological stress and physical activity (r = -0.209, SE = 0.050, 95% CI = [-0.307, -0.110]). The within-person associations between physical activity and subsequent psychological stress (b = -0.069, SE = 0.048, 95% CI = [-0.162, 0.024]) as well as stress and subsequent physical activity (b = -0.094, SE = 0.105, 95% CI = [-0.301, 0.112]) were non-significant, but medium-to-large ( β 1 2 ${beta }_{1to 2}$  = -0.114, β 2 3 ${beta }_{2to 3}$  = -0.111) and small-to-medium ( β 1 2 ${beta }_{1to 2}$  = -0.065, β 2 3 ${beta }_{2to 3}$ -0.057) in magnitude, respectively. Our findings demonstrate that, on average, individuals participating in greater levels of physical activity report lower stress. Further research is needed to explore the discrepancy between the significant between-person effects and the non-significant within-person cross-lagged effects.

充分证明体育活动可以减少压力和健康风险。频繁或长期的心理压力会增加身心健康疾病的风险。此外,高压力也可能损害身体活动行为。800名成年人(男性= 41.47,SD = 13.61;女性= 47.5%)在基线时完成了问卷调查,并进行了一到两个月的随访,用于测量身体活动和心理压力。采用随机截距交叉滞后面板模型来探讨体力活动与心理压力之间的双向、逐月关联。心理压力与体力活动之间存在显著的人际关联(r = -0.209, SE = 0.050, 95% CI =[-0.307, -0.110])。within-person身体活动之间的联系和随后的心理压力(b = -0.069, = 0.048, 95% CI =[-0.162, 0.024])以及压力和随后的身体活动(b = -0.094, = 0.105, 95% CI =[-0.301, 0.112])与,但是大中型(β(1→2 ${β}_{1 2}= -0.114美元,β2→3 ${β}_{2 3}= -0.111美元)和中小型(β(1→2 ${β}_{1 2}= -0.065美元,β2→3 ${β}_{2 3}$ -0.057)大小,分别。我们的研究结果表明,平均而言,参加更高水平体育活动的人报告的压力更小。显著的人间效应与不显著的人内交叉滞后效应之间的差异有待进一步研究。
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引用次数: 0
Assessing the Role of Appraisals of Challenge and Hindrance Stressors on Job Satisfaction and Turnover Intention. 挑战与阻碍压力源评价对工作满意度与离职倾向的影响。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70116
Gargi Sawhney, Austin Cunningham, Jesse S Michel

Despite being one of the most prevalent stress models in the organisational psychology and management literature, the challenge-hindrance stress model has come under criticism for inconsistent results. The current study seeks to investigate the role of stressor appraisals as a boundary condition of challenge and hindrance stressors in predicting employee engagement and exhaustion, strengthening the foundation of the model, and offering a potential explanation for previous mixed findings. Building on existing literature, we also probe the mediating role of engagement in the challenge stressors-job satisfaction relationship, Additionally, we explore whether exhaustion serves as a mechanism in the hindrance stressors and turnover intentions link. Using a daily diary design, workers from Amazon's Mechanical Turk completed two surveys per day for 10 weekdays (Level-1 N = 1344 observations; Level-2 N = 164 participants). Results indicated that challenge and hindrance appraisals of both challenge and hindrance stressors moderated the effects on engagement and exhaustion. Additionally, while engagement was found to mediate the effects of challenge stressors on job satisfaction, exhaustion did not mediate the relationship between hindrance stressors and turnover intentions. These findings highlight the need for stressor appraisal integration into the challenge-hindrance model and offer insights relating to employee stress management.

尽管是组织心理学和管理文献中最流行的压力模型之一,但挑战-障碍压力模型因结果不一致而受到批评。本研究旨在探讨压力源评价作为挑战压力源和障碍压力源的边界条件在预测员工敬业度和倦怠中的作用,加强模型的基础,并为之前的混合结果提供潜在的解释。在现有文献的基础上,我们还探讨了敬业度在挑战压力源-工作满意度关系中的中介作用,此外,我们还探讨了倦怠是否在阻碍压力源和离职意向之间起作用。使用每日日记设计,来自亚马逊土耳其机器人的员工在10个工作日内每天完成两次调查(一级N = 1344个观察对象;二级N = 164个参与者)。结果表明,挑战和障碍应激源的挑战和障碍评价调节了参与和疲劳的影响。此外,敬业度在挑战压力源对工作满意度的影响中起中介作用,而疲劳度在阻碍压力源对离职意向的影响中不起中介作用。这些发现强调了将压力源评估整合到挑战-障碍模型中的必要性,并提供了与员工压力管理相关的见解。
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引用次数: 0
Behind the Scenes: Affiliate Stigma and Posttraumatic Distress Among Mothers of Children With Neuropsychiatric Disorders. 幕后:在患有神经精神疾病的儿童的母亲中附属耻辱和创伤后痛苦。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70118
Yael Lahav, Anat Shalev

Mothers of children with neuropsychiatric disorders, such as autism and mental health disorders, are at risk for posttraumatic stress symptoms (PTSS) due to exposure to trauma related to their children's upbringing. Additionally, research suggests that these mothers may develop affiliate stigma, meaning they internalise the stigmatisation associated with their children, which may further heighten their vulnerability to trauma. However, this supposition has not yet been tested. Bridging this knowledge gap, this cross-sectional study explored the role of affiliate stigma in the relationship between the number of traumatic events and PTSS in mothers of children with autism and mental health disorders. An online survey was conducted among Israeli mothers using self-report measures. The sample consisted of 1448 mothers: 208 mothers of children with autism or mental health disorders, and 1240 mothers of children without disabilities. Results indicated that mothers of children with autism or mental health disorders were exposed to a greater number of traumatic events and exhibited elevated PTSS compared to mothers of children without disabilities. Affiliate stigma was associated with PTSS and moderated the relationship between the number of traumatic events and intrusion and hyperarousal symptoms: although the number of traumatic events explained increased intrusion and hyperarousal symptoms, this effect was stronger under conditions of high affiliate stigma. The present results suggest that mothers of children with neuropsychiatric disorders who internalise stigmatisation regarding their children may be particularly vulnerable to posttraumatic distress. Therefore, clinical interventions targeting affiliate stigma may be imperative for this population.

患有神经精神疾病(如自闭症和精神健康障碍)的儿童的母亲,由于暴露于与儿童成长有关的创伤,有患创伤后应激症状(PTSS)的风险。此外,研究表明,这些母亲可能会产生附属耻辱感,这意味着她们将与孩子相关的耻辱感内化,这可能会进一步增加她们对创伤的脆弱性。然而,这一假设尚未得到验证。弥合这一知识差距,本横断面研究探讨了附属耻辱在自闭症和精神健康障碍儿童的母亲创伤性事件数量和创伤后应激障碍之间的关系中的作用。在以色列母亲中进行了一项在线调查,采用自我报告方法。样本包括1448名母亲:208名患有自闭症或精神健康障碍儿童的母亲,以及1240名无残疾儿童的母亲。结果表明,与无残疾儿童的母亲相比,患有自闭症或精神健康障碍儿童的母亲暴露于更多的创伤性事件,并表现出更高的创伤后应激障碍。附属耻辱感与ptsd相关,并调节创伤性事件数量与侵入性和高唤醒症状之间的关系:尽管创伤性事件数量解释了侵入性和高唤醒症状的增加,但这种影响在高附属耻辱感条件下更强。目前的研究结果表明,患有神经精神疾病的孩子的母亲,如果对自己的孩子有内在化的污名化,可能特别容易受到创伤后痛苦的影响。因此,针对附属病耻感的临床干预措施可能对这一人群至关重要。
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引用次数: 0
Hsp70 and Hsp90 as Molecular Correlates of Anxiety in Children and Adolescents: The Role of Early-Life Stress. Hsp70和Hsp90是儿童和青少年焦虑的分子相关因素:早期生活压力的作用。
IF 2.7 2区 心理学 Q2 PSYCHIATRY Pub Date : 2025-10-01 DOI: 10.1002/smi.70109
Seda Kafali, Selma Tural Hesapcioglu, Mehmet Emin Seker, Mehmet Fatih Ceylan

Hsp70 and Hsp90, members of the heat shock protein family known for their cell-protective effects against stress at the molecular level. This study aims to compare the Hsp70 and Hsp90 levels in children and adolescents with anxiety disorders and the healthy controls and to investigate the relation between Hsp70 and Hsp90 levels and the clinical parameters. The study group consisted of children and adolescents aged 8-18 who applied to the child and adolescent psychiatry outpatient clinic and were diagnosed with anxiety disorders and a healthy control group of similar age and gender. The Sociodemographic and Clinical Data Form, Screen for Child Anxiety Related Disorders, Children's Depression Inventory, and Clinical Global Impressions Scale were used. Venous blood samples were collected from the participants, and serum Hsp70 and Hsp90 levels were measured using the ELISA method. Serum levels of Hsp70 and Hsp90 were significantly lower in children and adolescents diagnosed with anxiety disorders compared to healthy controls (Hsp70: p = 0.019; Hsp90: p = 0.043). While no significant correlation was found between Hsp levels and disease severity, exposure to early-life stress (ELS) was associated with a significant increase in Hsp70 levels overall (p = 0.005). However, among participants exposed to ELS, those in the anxiety disorder group exhibited a markedly smaller increase in Hsp70 compared to controls with ELS exposure, suggesting a possible dysregulation of the cellular stress response in this clinical population. The results of our study indicate that psychological stress in anxiety disorders may be linked to changes in cellular stress-related mechanisms. The reduction in serum levels of heat shock proteins, which help maintain cellular stability under stress, may contribute to the pathophysiology of anxiety disorders. However, further studies using additional cellular and molecular markers are warranted to validate these findings.

Hsp70和Hsp90是热休克蛋白家族的成员,以其在分子水平上对应激的细胞保护作用而闻名。本研究旨在比较儿童和青少年焦虑症患者与健康对照组的Hsp70和Hsp90水平,探讨Hsp70和Hsp90水平与临床参数的关系。研究小组包括8-18岁申请儿童和青少年精神病学门诊并被诊断患有焦虑症的儿童和青少年,以及年龄和性别相似的健康对照组。使用了社会人口学和临床数据表、儿童焦虑相关障碍筛查、儿童抑郁量表和临床总体印象量表。采集受试者静脉血,ELISA法测定血清Hsp70和Hsp90水平。诊断为焦虑症的儿童和青少年的血清Hsp70和Hsp90水平明显低于健康对照组(Hsp70: p = 0.019; Hsp90: p = 0.043)。虽然热休克蛋白水平与疾病严重程度之间没有发现显著相关性,但暴露于早期生活压力(ELS)与总体热休克蛋白70水平显著升高相关(p = 0.005)。然而,在暴露于ELS的参与者中,与暴露于ELS的对照组相比,焦虑障碍组的Hsp70的增加明显较小,这表明该临床人群中细胞应激反应可能失调。我们的研究结果表明,焦虑障碍的心理压力可能与细胞压力相关机制的变化有关。血清热休克蛋白水平的降低,有助于在压力下维持细胞稳定性,可能有助于焦虑障碍的病理生理学。然而,进一步的研究需要使用额外的细胞和分子标记来验证这些发现。
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Stress and Health
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