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Long-term Outcomes in Orthogeriatric Co-management: a Literature Review. 骨科老年病共同管理的长期成果:文献综述。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-10-01 Epub Date: 2023-09-12 DOI: 10.1055/a-2134-5803
Andrea Eiter, Jan Daniel Kellerer

Fragility fractures of the hip are one of the most important triggers of poor health outcomes in older adults. They often result in limitations in the ability of patients to care for themselves and mortality remains high. Orthogeriatric co-management may improve outcomes for this high-risk population. However, the impact on long-term results has not yet been definitively clarified. The purpose of this study was to present the influence of orthogeriatric co-management on mortality and self-care ability, as measured by the Barthel score, one year after hip fracture in people ≥ 60 years.A systematic literature search was performed in accordance with the process steps of identification, selection, and evaluation, with a systematic search of the MEDLINE, CINAHL Complete and Cochrane Library databases in the period from February to March 2022. Articles in English and German published between 2012 and 2022 were included. Twelve studies were finally used.Six studies demonstrated a statistically significant reduction in the one-year mortality rate. Only one of four studies evaluating self-care ability showed a significant improvement when the patient was treated on a specialised ward.Orthogeriatric co-management seems to be beneficial in positively influencing one-year mortality and self-care ability. In view of the heterogeneous results, the implementation of this care model can only be recommended to a limited extent.

髋部脆性骨折是导致老年人健康状况不良的最重要诱因之一。髋部脆性骨折常常导致患者生活自理能力受限,死亡率居高不下。骨科共同管理可改善这一高风险人群的预后。然而,其对长期治疗效果的影响尚未明确。本研究的目的是通过对MEDLINE、CINAHL Complete和Cochrane Library数据库的系统检索,按照识别、选择和评估的流程步骤,对2022年2月至3月期间发表的英语和德语文章进行系统检索。其中包括 2012 年至 2022 年间发表的英文和德文文章。六项研究表明,一年期死亡率在统计学上有显著降低。在评估自理能力的四项研究中,只有一项研究显示,在专科病房接受治疗的患者自理能力显著提高。鉴于研究结果各不相同,我们只能在有限的范围内建议实施这种护理模式。
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引用次数: 0
S2k Guideline for Tibial Plateau Fractures - Classification, Diagnosis, and Treatment. 胫骨平台骨折 - 分类、诊断和治疗 S2k 指南。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-10-01 Epub Date: 2023-09-06 DOI: 10.1055/a-2121-6538
Markus Thomas Berninger, Jan Philipp Schüttrumpf, Stefan Barzen, Christoph Domnick, Lena Eggeling, Kai Fehske, Karl-Heinz Frosch, Elmar Herbst, Reinhard Hoffmann, Kaywan Izadpanah, Clemens Kösters, Mirjam Neumann-Langen, Michael Raschke, Johannes Zellner, Matthias Krause

Tibial plateau fractures are mostly complex and surgically demanding joint fractures, which require a comprehensive understanding of the fracture morphology, ligamentous and neurovascular injuries, as well as the diagnostic and therapeutic options for an optimal clinical outcome. Therefore, a standardised and structured approach is required. The success of the treatment of tibial plateau fractures relies on the interdisciplinary cooperation between surgical and conservative physicians in an outpatient and inpatient setting, physical therapists, patients and service providers (health insurance companies, statutory accident insurance, pension providers). On behalf of the German Society for Orthopaedics and Trauma Surgery (DGOU), the German Trauma Society (DGU) and the Society for Arthroscopy and Joint Surgery (AGA), under the leadership of the Fracture Committee of the German Knee Society (DKG), a guideline for tibial plateau fractures was created, which was developed in several voting rounds as part of a Delphi process. Based on the current literature, this guideline is intended to make clear recommendations and outline the most important treatment steps in diagnostics, therapy and follow-up treatment. Additionally, 25 statements were revised by the authors in several survey rounds using the Likert scale in order to reach a final consensus.

胫骨平台骨折大多是复杂的关节骨折,手术要求高,需要全面了解骨折形态、韧带和神经血管损伤以及诊断和治疗方案,才能获得最佳临床效果。因此,需要一种标准化和结构化的方法。胫骨平台骨折的成功治疗有赖于门诊和住院环境中手术和保守治疗医生、理疗师、患者和服务提供商(医疗保险公司、法定意外保险、养老金提供商)之间的跨学科合作。在德国膝关节学会(DKG)骨折委员会的领导下,德国骨科与创伤外科学会(DGOU)、德国创伤学会(DGU)和关节镜与关节外科学会(AGA)代表德国膝关节学会(DKG)制定了胫骨平台骨折指南,该指南是德尔菲程序的一部分,经过多轮投票制定而成。该指南以现有文献为基础,旨在提出明确的建议,并概述诊断、治疗和后续治疗中最重要的治疗步骤。此外,作者还在几轮调查中使用李克特量表对 25 项陈述进行了修订,以达成最终共识。
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引用次数: 0
Long-term Outcomes after Medial Open Wedge High Tibial Osteotomy - A Retrospective Study of 69 Patients. 内侧开放式楔形胫骨高位截骨术后的长期疗效--69 例患者的回顾性研究。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-10-01 Epub Date: 2023-08-30 DOI: 10.1055/a-2120-0993
Steffen Schröter, Julian Klink, Christoph Ihle, Boyko Guergov Gueorguiev, Moritz Herbst, Marco Maiotti, Tina Histing, Marc-Daniel Ahrend

High tibial osteotomy (HTO) is a widespread option to avoid or delay total knee arthroplasty (TKA). The present study aimed to assess the long-term survival rate and postoperative subjective knee function after isolated medial open wedge HTO in patients with symptomatic medial compartment knee osteoarthritis (OA) and varus malalignment.Sixty-nine patients (48.8 ± 6.7, 35-66 years; preoperative mechanical tibiofemoral angle [mTFA] -5.3 ± 3.4; -14.9-0.0° varus) treated with medial open wedge HTO using a TomoFix plate were included in this retrospective study, with a follow-up of at least 10 years (11.8 ± 1.0 years). The survival rate after HTO was calculated after 5 and 10 years. Subjective knee function was assessed using Hospital for Special Surgery (HSS), Oxford knee, Lequesne, and Lysholm scores.Thirty-three patients underwent conversion to TKA, on average, 7.0 ± 3.4 (1.3-13.7) years after HTO. Five- and ten-year survival rates were 84.1 and 60.9%, respectively. Patients without conversion to TKA showed a Lysholm score of 64.5 (35-92), Lequesne score of 7 (1-13), HSS score of 71 (56-86), and Oxford knee score of 38.5 (25-44) at the last follow-up (more than 10 years). Significantly higher scores were registered at the last follow-up compared to the preoperative state regarding the Lysholm score (preoperative: 43.5 [12-95]; follow-up: 64.5 [35-92]; p < 0.001). The HSS score (preoperative: 69.5 [43-93]; follow-up: 71 [56-86]; p = 0.6941) showed no statistically significant change during the 10-year follow-up period. The Lequesne score was significantly lower than the preoperative score (preoperative: 11.5 [0.5-22]; follow-up: 7 [1-13]; p < 0.001), indicating a lower handicap.The majority of patients with a valgus medial compartmental knee OA treated with HTO with fixation using the TomoFix plate can expect no conversion to TKA for more than 10 years. Furthermore, patients without conversion to TKA after 10 years still had a significantly higher subjective knee function than preoperatively. Further research is needed to identify risk factors for conversion to TKA. This helps to guide surgeons in selecting patients who will benefit most from HTO.

胫骨高位截骨术(HTO)是避免或推迟全膝关节置换术(TKA)的一种普遍选择。本研究旨在评估有症状的内侧室膝关节骨性关节炎(OA)和膝关节屈曲不正患者行孤立的内侧开放楔形 HTO 术后的长期存活率和术后主观膝关节功能。这项回顾性研究纳入了 69 例使用 TomoFix 钢板进行内侧开放式楔形 HTO 治疗的患者(48.8 ± 6.7,35-66 岁;术前机械胫骨股骨角 [mTFA] -5.3 ± 3.4;-14.9-0.0° 曲位),随访时间至少 10 年(11.8 ± 1.0 年)。计算了 HTO 术后 5 年和 10 年的存活率。33 名患者在 HTO 后平均 7.0 ± 3.4(1.3-13.7)年转为 TKA。五年和十年生存率分别为84.1%和60.9%。未转为 TKA 的患者在最后一次随访(超过 10 年)时的 Lysholm 评分为 64.5(35-92),Lequesne 评分为 7(1-13),HSS 评分为 71(56-86),牛津膝关节评分为 38.5(25-44)。与术前相比,最后一次随访时的 Lysholm 评分明显更高(术前:43.5 [12-95];随访:64.5 [35-92];p
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引用次数: 0
Intraoperative Periprosthetic Femur Fracture - When is the Cerclage Enough? 术中假体周围股骨骨折--何时Cerclage就足够了?
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2023-08-29 DOI: 10.1055/a-2051-8613
Sebastian Hardt, Gregor Giebel, Robert Hube

Background and planning: Intraoperative periprosthetic femoral fractures are among the most serious complications in both primary and revision arthroplasty. They are often not detected, despite intraoperative radiological control. Since an unnoticed intraoperative fracture often requires revision surgery, which has been associated with increased mortality rates, intraoperative diagnosis and corresponding direct and sufficient treatment are crucial. There are patient-, surgery-, and implant-specific risk factors that increase the possibilities of intraoperative fractures. The most common risk factors on the patient side are age, gender, and various pre-existing conditions, such as osteoporosis or rheumatic diseases. A minimally invasive approach and a cementless press-fit fixation are the most significant surgery- and implant-specific risk factors. The Vancouver classification or the modified Mallory classification are available for the classification of intraoperative periprosthetic femoral fractures. Based on these classifications, treatment recommendations can be derived. Different strategies are available for fracture management.

Therapy: Generally, if the stem is stable, osteosynthesis can be performed with preservation of the implant. This procedure can be applied to the majority of cases with non-displaced fractures by using cerclages as fixation. An unstable implant may require replacement of the stem. In higher grade fractures, stabilisation by using plate osteosynthesis may be necessary. The aim is to achieve the most anatomical reposition possible for the best possible bony consolidation. The ultimate goal is high implant stability and restoration of the biomechanics.

背景与规划:术中股骨假体周围骨折是初次和翻修关节置换术中最严重的并发症之一。尽管术中进行了放射学检查,但这些骨折通常不会被发现。由于术中未被发现的骨折往往需要进行翻修手术,而翻修手术与死亡率的增加有关,因此术中诊断以及相应的直接和充分治疗至关重要。患者、手术和植入物的特定风险因素会增加术中骨折的可能性。患者方面最常见的风险因素是年龄、性别和各种原有疾病,如骨质疏松症或风湿病。微创方法和无骨水泥压入式固定是最重要的手术和植入物风险因素。术中股骨假体周围骨折的分类可采用温哥华分类法或改良马洛里分类法。根据这些分类,可以得出治疗建议。骨折治疗有不同的策略:一般来说,如果骨干稳定,可在保留植入物的情况下进行骨合成术。这种方法适用于大多数无移位骨折的病例,使用陶瓷环作为固定物。不稳定的植入体可能需要更换骨干。对于等级较高的骨折,可能需要使用钢板骨合成术进行稳定。这样做的目的是尽可能地进行解剖复位,以达到最佳的骨质巩固效果。最终目标是实现植入物的高度稳定性和生物力学的恢复。
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引用次数: 0
Epidemiology of Surgically Treated Spinal Tumors: A Multicenter Surveillance Study of 9686 Patients from the German Spine Registry (DWG Register). 经手术治疗的脊柱肿瘤的流行病学:来自德国脊柱登记处(DWG 登记处)的 9686 名患者的多中心监测研究。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2023-06-12 DOI: 10.1055/a-2077-7155
Sebastian G Walter, Christopher Gaisendrees, Nikolaus Kernich, Maximilian Weber, Max J Scheyerer, Peer Eysel, Jan Siewe, Kourosh Zarghooni

Tumors of the spine are challenging in terms of diagnoses and interdisciplinary treatment. This study was conducted to evaluate and characterize a large multicenter cohort of surgically treated spine tumor patients.Data of the German Spine Society (DWG) were used to characterize a cohort of all surgically treated spine tumor cases that were registered between 2017 and 2021. Subgroup analysis was performed for tumor entity, tumor localization, height of most severely affected segments, surgical treatment, and demographic parameters.In total, there were 9686 cases, of which 6747 were "malignant", 1942 were "primary benign", 180 were "tumor-like lesions", and 488 were "other" spinal tumors. Subgroups showed differences in number of affected segments as well as localization. There were further significant differences in surgical complication rates (p = 0.003), age (p < 0.001), morbidity (p < 0.001), and duration of surgery (p = 0.004).This is a representative study on spinal tumors from a large spine registry and allows for the epidemiological characterization of surgically treated tumor subgroups and quality control of registry data.

脊柱肿瘤在诊断和跨学科治疗方面具有挑战性。这项研究旨在对接受过手术治疗的大型多中心脊柱肿瘤患者队列进行评估和特征描述。研究使用了德国脊柱协会(DWG)的数据,对2017年至2021年间登记的所有接受过手术治疗的脊柱肿瘤病例进行特征描述。共9686例,其中6747例为 "恶性",1942例为 "原发性良性",180例为 "肿瘤样病变",488例为 "其他 "脊柱肿瘤。亚组在受累节段数量和定位方面存在差异。在手术并发症发生率(P = 0.003)、年龄(P = 0.005)、病变部位(P = 0.005)和病变类型(P = 0.005)方面也存在明显差异。
{"title":"Epidemiology of Surgically Treated Spinal Tumors: A Multicenter Surveillance Study of 9686 Patients from the German Spine Registry (DWG Register).","authors":"Sebastian G Walter, Christopher Gaisendrees, Nikolaus Kernich, Maximilian Weber, Max J Scheyerer, Peer Eysel, Jan Siewe, Kourosh Zarghooni","doi":"10.1055/a-2077-7155","DOIUrl":"10.1055/a-2077-7155","url":null,"abstract":"<p><p>Tumors of the spine are challenging in terms of diagnoses and interdisciplinary treatment. This study was conducted to evaluate and characterize a large multicenter cohort of surgically treated spine tumor patients.Data of the German Spine Society (DWG) were used to characterize a cohort of all surgically treated spine tumor cases that were registered between 2017 and 2021. Subgroup analysis was performed for tumor entity, tumor localization, height of most severely affected segments, surgical treatment, and demographic parameters.In total, there were 9686 cases, of which 6747 were \"malignant\", 1942 were \"primary benign\", 180 were \"tumor-like lesions\", and 488 were \"other\" spinal tumors. Subgroups showed differences in number of affected segments as well as localization. There were further significant differences in surgical complication rates (p = 0.003), age (p < 0.001), morbidity (p < 0.001), and duration of surgery (p = 0.004).This is a representative study on spinal tumors from a large spine registry and allows for the epidemiological characterization of surgically treated tumor subgroups and quality control of registry data.</p>","PeriodicalId":51219,"journal":{"name":"Zeitschrift Fur Orthopadie Und Unfallchirurgie","volume":" ","pages":"403-409"},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Description of Standardized Planes and Angles for Percutaneous Supra-acetabular Screw Placement. 描述经皮髋臼上螺钉置入的标准化平面和角度。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2023-07-18 DOI: 10.1055/a-2107-0948
Julian Rüwald, Milena Maria Ploeger, Gunnar T Hischebeth, Mareike Tüllmann, Jonas Roos, Martin Gathen, Koroush Kabir

Background: Percutaneous screw fixation for pelvic fractures has become a minimally invasive alternative to an open operation. The complex anatomy of the pelvis renders this procedure challenging. The objective of this study was to assess standardized angles and dimensions of safety zones within a 3 D computed tomography model for optimal supra-acetabular screw placement.

Methods: Computed tomography scans of 107 patients that suffered major trauma without showing any bone injury of the pelvis were collected. Using a software-based analysis, raw computed tomography data were transformed into 3 D models to set standardized landmarks and determine the possible insertion corridor.

Results: Screws not exceeding a length of 97 mm in females and 106.4 mm in males were, in 95% of the evaluated cases, insertable without cortical bone penetration. The safety zone was 6.6 mm for females and 7.9 mm for males. Screws not exceeding these diameters were safely insertable in 95% of the cases. For the midsagittal plane, the angle was 36.4 ± 5.1 on the left and 34.7 ± 2.9 on the right (p = 0.008). For the anterior pelvic plane, the angle was 31.3 ± 4.5° on the left and 34.0 ± 4.8° on the right (p = 0.008).

Conclusions: Percutaneous fixation using supra-acetabular screws is a promising method to treat simple supra-acetabular fractures. These results may improve its safe utilization and could facilitate its broader clinical application.

背景:经皮螺钉固定骨盆骨折已成为开放手术的微创替代方法。骨盆复杂的解剖结构使这一手术具有挑战性。本研究的目的是评估 3 D 计算机断层扫描模型中安全区的标准化角度和尺寸,以实现最佳的髋臼上螺钉置入:方法: 收集了 107 名遭受重大创伤但骨盆未显示任何骨质损伤的患者的计算机断层扫描图像。通过软件分析,将原始计算机断层扫描数据转化为 3 D 模型,以设定标准化地标并确定可能的插入走廊:结果:在 95% 的评估病例中,女性的螺钉长度不超过 97 毫米,男性不超过 106.4 毫米,均可在不穿透皮质骨的情况下插入。安全区女性为 6.6 毫米,男性为 7.9 毫米。在 95% 的病例中,不超过这些直径的螺钉均可安全插入。在中矢状面,左侧的角度为 36.4 ± 5.1,右侧为 34.7 ± 2.9(P = 0.008)。骨盆前平面的角度左侧为 31.3 ± 4.5°,右侧为 34.0 ± 4.8°(P = 0.008):结论:使用髋臼上螺钉进行经皮固定是一种治疗简单髋臼上骨折的有效方法。结论:使用髋臼上螺钉经皮固定治疗简单的髋臼上骨折是一种很有前景的方法,这些结果可能会提高其安全性,并促进其更广泛的临床应用。
{"title":"Description of Standardized Planes and Angles for Percutaneous Supra-acetabular Screw Placement.","authors":"Julian Rüwald, Milena Maria Ploeger, Gunnar T Hischebeth, Mareike Tüllmann, Jonas Roos, Martin Gathen, Koroush Kabir","doi":"10.1055/a-2107-0948","DOIUrl":"10.1055/a-2107-0948","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous screw fixation for pelvic fractures has become a minimally invasive alternative to an open operation. The complex anatomy of the pelvis renders this procedure challenging. The objective of this study was to assess standardized angles and dimensions of safety zones within a 3 D computed tomography model for optimal supra-acetabular screw placement.</p><p><strong>Methods: </strong>Computed tomography scans of 107 patients that suffered major trauma without showing any bone injury of the pelvis were collected. Using a software-based analysis, raw computed tomography data were transformed into 3 D models to set standardized landmarks and determine the possible insertion corridor.</p><p><strong>Results: </strong>Screws not exceeding a length of 97 mm in females and 106.4 mm in males were, in 95% of the evaluated cases, insertable without cortical bone penetration. The safety zone was 6.6 mm for females and 7.9 mm for males. Screws not exceeding these diameters were safely insertable in 95% of the cases. For the midsagittal plane, the angle was 36.4 ± 5.1 on the left and 34.7 ± 2.9 on the right (p = 0.008). For the anterior pelvic plane, the angle was 31.3 ± 4.5° on the left and 34.0 ± 4.8° on the right (p = 0.008).</p><p><strong>Conclusions: </strong>Percutaneous fixation using supra-acetabular screws is a promising method to treat simple supra-acetabular fractures. These results may improve its safe utilization and could facilitate its broader clinical application.</p>","PeriodicalId":51219,"journal":{"name":"Zeitschrift Fur Orthopadie Und Unfallchirurgie","volume":" ","pages":"419-425"},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Rivaroxaban and Enoxaparin for Thromboprophylaxis Among Total Hip Arthroplasty Patients: A Systematic Review and Meta-Analysis. 全髋关节置换术患者使用利伐沙班和依诺肝素预防血栓形成的有效性和安全性:系统综述与元分析》。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2023-01-30 DOI: 10.1055/a-1994-7500
Chong Wang, Shuhua Lan, Panpan Xie, Ruifeng Yang

Background: Venous thromboembolism (VTE) is one of the major and potentially life-threatening complications following major orthopedic surgeries. Research evidence comparing the effectiveness of rivaroxaban and enoxaparin for thromboprophylaxis specific to total hip arthroplasty (THA) has been limited. Hence, this review was done to compare the efficacy and safety of rivaroxaban against enoxaparin for thromboprophylaxis after THA.

Materials and methods: We conducted a search in databases including Medline, EMBASE, ScienceDirect, Google Scholar, and Cochrane Library from inception until May 2021. Randomized controlled trials directly comparing the effectiveness of rivaroxaban and enoxaparin for thromboprophylaxis among patients undergoing THA were eligible for inclusion. Outcome parameters assessed were efficacy in terms of total VTE and all-cause mortality, major VTE, deep vein thrombosis, symptomatic VTE, and safety in terms of major bleeding events, clinically relevant nonmajor bleeding events, minor bleeding events, total bleeding events, drug-related adverse events, and wound infection. We performed a meta-analysis with a random effects model and reported a pooled risk ratio (RR) with a 95% confidence interval (CI).

Results: Eleven studies, including 9057 participants, were analyzed. Amongst efficacy outcomes, VTE and all-cause mortality pooled an RR of 0.58 (95% CI: 0.34-0.99), major VTE pooled an RR of 0.37 (95% CI: 0.15-0.90), deep vein thrombosis pooled an RR of 0.57 (95% CI: 0.32-1.02), and symptomatic VTE pooled an RR of 0.51 (95% CI: 0.30-0.87). Amongst safety outcomes, major bleeding events pooled an RR of 1.18 (95% CI: 0.77-1.80), total bleeding events pooled an RR of 1.12 (95% CI: 0.93-1.34), drug-related adverse event pooled an RR of 0.99 (95% CI: 0.87-1.12), and wound infection pooled an RR of 1.11 (95% CI: 0.58-2.14).

Conclusion: Rivaroxaban is a more efficacious drug in terms of VTE and all-cause mortality compared to enoxaparin following THA, and rivaroxaban was non-inferior in terms of safety profiles such as wound infection, bleeding, and drug-related adverse events.

背景:静脉血栓栓塞症(VTE)是重大骨科手术后的主要并发症之一,有可能危及生命。比较利伐沙班和依诺肝素对全髋关节置换术(THA)血栓预防效果的研究证据非常有限。因此,本综述旨在比较利伐沙班和依诺肝素在全髋关节置换术后预防血栓形成的有效性和安全性:我们在 Medline、EMBASE、ScienceDirect、Google Scholar 和 Cochrane Library 等数据库中进行了检索,检索时间从开始到 2021 年 5 月。直接比较利伐沙班和依诺肝素对接受 THA 患者血栓预防效果的随机对照试验符合纳入条件。评估的结果参数包括总 VTE 和全因死亡率、主要 VTE、深静脉血栓、无症状 VTE 的有效性,以及主要出血事件、临床相关的非主要出血事件、轻微出血事件、总出血事件、药物相关不良事件和伤口感染的安全性。我们采用随机效应模型进行了荟萃分析,并报告了汇总风险比(RR)及 95% 置信区间(CI):结果:共分析了 11 项研究,包括 9057 名参与者。在疗效结果中,VTE和全因死亡率的总RR为0.58(95% CI:0.34-0.99),主要VTE的总RR为0.37(95% CI:0.15-0.90),深静脉血栓形成的总RR为0.57(95% CI:0.32-1.02),症状性VTE的总RR为0.51(95% CI:0.30-0.87)。在安全性结果中,大出血事件汇总RR为1.18(95% CI:0.77-1.80),总出血事件汇总RR为1.12(95% CI:0.93-1.34),药物相关不良事件汇总RR为0.99(95% CI:0.87-1.12),伤口感染汇总RR为1.11(95% CI:0.58-2.14):结论:与依诺肝素相比,利伐沙班对THA术后VTE和全因死亡率的疗效更好,而在伤口感染、出血和药物相关不良事件等安全性方面,利伐沙班并不劣于依诺肝素。
{"title":"Efficacy and Safety of Rivaroxaban and Enoxaparin for Thromboprophylaxis Among Total Hip Arthroplasty Patients: A Systematic Review and Meta-Analysis.","authors":"Chong Wang, Shuhua Lan, Panpan Xie, Ruifeng Yang","doi":"10.1055/a-1994-7500","DOIUrl":"10.1055/a-1994-7500","url":null,"abstract":"<p><strong>Background: </strong>Venous thromboembolism (VTE) is one of the major and potentially life-threatening complications following major orthopedic surgeries. Research evidence comparing the effectiveness of rivaroxaban and enoxaparin for thromboprophylaxis specific to total hip arthroplasty (THA) has been limited. Hence, this review was done to compare the efficacy and safety of rivaroxaban against enoxaparin for thromboprophylaxis after THA.</p><p><strong>Materials and methods: </strong>We conducted a search in databases including Medline, EMBASE, ScienceDirect, Google Scholar, and Cochrane Library from inception until May 2021. Randomized controlled trials directly comparing the effectiveness of rivaroxaban and enoxaparin for thromboprophylaxis among patients undergoing THA were eligible for inclusion. Outcome parameters assessed were efficacy in terms of total VTE and all-cause mortality, major VTE, deep vein thrombosis, symptomatic VTE, and safety in terms of major bleeding events, clinically relevant nonmajor bleeding events, minor bleeding events, total bleeding events, drug-related adverse events, and wound infection. We performed a meta-analysis with a random effects model and reported a pooled risk ratio (RR) with a 95% confidence interval (CI).</p><p><strong>Results: </strong>Eleven studies, including 9057 participants, were analyzed. Amongst efficacy outcomes, VTE and all-cause mortality pooled an RR of 0.58 (95% CI: 0.34-0.99), major VTE pooled an RR of 0.37 (95% CI: 0.15-0.90), deep vein thrombosis pooled an RR of 0.57 (95% CI: 0.32-1.02), and symptomatic VTE pooled an RR of 0.51 (95% CI: 0.30-0.87). Amongst safety outcomes, major bleeding events pooled an RR of 1.18 (95% CI: 0.77-1.80), total bleeding events pooled an RR of 1.12 (95% CI: 0.93-1.34), drug-related adverse event pooled an RR of 0.99 (95% CI: 0.87-1.12), and wound infection pooled an RR of 1.11 (95% CI: 0.58-2.14).</p><p><strong>Conclusion: </strong>Rivaroxaban is a more efficacious drug in terms of VTE and all-cause mortality compared to enoxaparin following THA, and rivaroxaban was non-inferior in terms of safety profiles such as wound infection, bleeding, and drug-related adverse events.</p>","PeriodicalId":51219,"journal":{"name":"Zeitschrift Fur Orthopadie Und Unfallchirurgie","volume":" ","pages":"368-381"},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10584303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fractures in Childhood and Young Adulthood According to Maternal Smoking in Late Pregnancy. A Danish Cohort Study. 妊娠晚期母亲吸烟对儿童和青少年骨折的影响。丹麦队列研究。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2023-07-18 DOI: 10.1055/a-2103-6915
Jannie Biolzi Rasmussen, Sabine Marie Rath, Chunsen Wu, Louise Kathrine Kjaer Weile, Hagen Schmal, Jørn Olsen, Bodil Hammer Bech, Ellen Aagaard Nohr

Fractures account for the most frequent cause of hospitalization during childhood and numbers have increased over time. Of all fractures in childhood and young adulthood, 66% are recurrent fractures, suggesting that some people are predestined for fractures. The aim of this study was to investigate the association between maternal smoking during late pregnancy and the risk of fractures in the children.The study included 11,082 mothers and their children from the cohort "Healthy Habits for Two" born between 1984 and 1987. Information about maternal smoking during pregnancy came from questionnaires filled out in pregnancy, while information about fractures was derived from the Danish National Patient Registry. Over a follow-up of 24 years (1994-2018), Cox regression with multiple failures was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for fractures in childhood and young adulthood according to maternal smoking in late pregnancy. Information about body mass index (BMI) and smoking status in young adulthood was included as time variant covariates.During an age span of 8-32 years, 6,420 fractures were observed. Of the mothers, 39.1% smoked during late pregnancy. Compared to children of mothers who did not smoke, children of mothers who smoked 1-9 cigarettes per day and 10+ cigarettes per day had an increased risk of fractures (HR 1.14 [CI: 1.06; 1.21] and HR 1.14 [CI: 1.07; 1.22], respectively). After adjusting for BMI and smoking status in young adulthood, the findings were slightly strengthened, showing an increased risk of fractures of 23 and 25% in children of mothers smoking 1-9 cigarettes per day and 10+ cigarettes per day, respectively.Maternal smoking during late pregnancy was associated with a higher risk of fractures in the child. This result indicates that exposure to cigarette smoke in utero may play a role in lifelong bone health.

骨折是儿童时期最常见的住院原因,而且随着时间的推移,骨折的数量也在不断增加。在儿童和青少年时期的所有骨折中,66%为复发性骨折,这表明有些人注定会发生骨折。这项研究的目的是调查母亲在妊娠晚期吸烟与儿童骨折风险之间的关系。研究对象包括 1984 年至 1987 年间出生的 "两人健康习惯 "队列中的 11,082 名母亲及其子女。有关母亲在怀孕期间吸烟的信息来自于在怀孕期间填写的调查问卷,而有关骨折的信息则来自于丹麦全国患者登记册。在长达 24 年(1994-2018 年)的随访过程中,我们采用多重失败的 Cox 回归方法,根据母亲在妊娠晚期吸烟的情况来估算儿童期和青年期骨折的危险比(HRs)和 95% 的置信区间(CIs)。体重指数(BMI)和年轻时的吸烟状况信息被列为时间变量协变量。其中,39.1%的母亲在妊娠晚期吸烟。与不吸烟母亲的子女相比,每天吸烟1-9支和10支以上母亲的子女发生骨折的风险更高(HR分别为1.14 [CI:1.06;1.21] 和HR 1.14 [CI:1.07;1.22])。在对体重指数和年轻时的吸烟状况进行调整后,研究结果略有加强,显示每天吸烟1-9支和每天吸烟10支以上的母亲,其子女的骨折风险分别增加23%和25%。这一结果表明,在子宫内暴露于香烟烟雾可能会对终生骨骼健康产生影响。
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引用次数: 0
The Clinical Outcomes of Measured Resection and Gap Balancing Techniques in Primary Total Knee Arthroplasty: A Meta-analysis. 初级全膝关节置换术中测量切除和间隙平衡技术的临床效果:一项 Meta 分析。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2023-05-23 DOI: 10.1055/a-2050-7621
Kun Liu, Zongqing Fan, Weina Liu, Li Li, YuJun Guan, Donglin Fu

Background: At present, the clinical efficacy of measured resection (MR) and gap balancing (GB) techniques in total knee arthroplasty (TKA) is still controversial. The objective of this study was to evaluate the clinical outcome indexes of the two surgical methods through a meta-analysis.

Methods: The literature was systematically searched on PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG, Weipu (VIP), and China Biomedical Literature (CBM) electronic databases inception until June 12, 2022. RevMan 5.3 software (the Nordic Cochrane Center, the Cochrane Collaboration, Copenhagen, Denmark) was used to analyze all data of this study. The Cochrane risk bias assessment tool is a risk bias evaluation criterion recommended by the Cochrane Handbook for systematic reviews.

Results: Eleven studies involving 1268 knees in total were included. The main outcome indexes showed that the Knee Society Score (KSS) knee score (MD: -1.40; 95% CI: -2.57 to -0.22; p = 0.02) and KSS knee function score (MD: -3.11; 95% CI: -3.72 to -2.50; p < 0.001) in the GB group were higher 1 year after operation, while femoral component rotation angle (FCRA; MD: -0.75; 95% CI: -1.34 to -0.07; p = 0.03) and the osteotomy volume of the posterior medial femoral condyle (MD: -0.76; 95% CI; -1.13 to -0.38; p < 0.001) were greater in the GB group. In addition, there was no significant difference in the joint line change (MD: -0.03; 95% CI: -0.07 to 0.01; p = 0.16) between the two groups. Secondary outcome results showed that the knee joint range of motion (ROM) in 3 months, and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score after 1 year were better in the GB group. However, the operation time of the MR group was shorter. In addition, this study revealed no significant differences in post-complications between these two groups.

Conclusion: Although the GB technique may not provide better radiographic results or reduce the complication rate, the recovery of joint function showed earlier improvement.

背景:目前,全膝关节置换术(TKA)中的测量切除(MR)和间隙平衡(GB)技术的临床疗效仍存在争议。本研究旨在通过荟萃分析评估两种手术方法的临床疗效指标:方法:系统检索了PubMed、EMBASE、Cochrane Library、中国知网(CNKI)、万方、维普(VIP)和中国生物医学文献(CBM)等电子数据库中截至2022年6月12日的文献。本研究使用 RevMan 5.3 软件(丹麦哥本哈根 Cochrane 合作组织北欧 Cochrane 中心)分析所有数据。Cochrane风险偏倚评估工具是《Cochrane系统综述手册》推荐的风险偏倚评估标准:结果:共纳入 11 项研究,涉及 1268 膝关节。主要结果指标显示,膝关节社会评分(KSS)膝关节评分(MD:-1.40;95% CI:-2.57 至 -0.22;P = 0.02)和 KSS 膝关节功能评分(MD:-3.11;95% CI:-3.72 至 -2.50;P 结论:虽然 GB 技术可能无法提供更好的膝关节功能,但它可以为膝关节提供更好的保护:虽然 GB 技术可能无法提供更好的影像学效果或降低并发症发生率,但关节功能的恢复却较早得到改善。
{"title":"The Clinical Outcomes of Measured Resection and Gap Balancing Techniques in Primary Total Knee Arthroplasty: A Meta-analysis.","authors":"Kun Liu, Zongqing Fan, Weina Liu, Li Li, YuJun Guan, Donglin Fu","doi":"10.1055/a-2050-7621","DOIUrl":"10.1055/a-2050-7621","url":null,"abstract":"<p><strong>Background: </strong>At present, the clinical efficacy of measured resection (MR) and gap balancing (GB) techniques in total knee arthroplasty (TKA) is still controversial. The objective of this study was to evaluate the clinical outcome indexes of the two surgical methods through a meta-analysis.</p><p><strong>Methods: </strong>The literature was systematically searched on PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG, Weipu (VIP), and China Biomedical Literature (CBM) electronic databases inception until June 12, 2022. RevMan 5.3 software (the Nordic Cochrane Center, the Cochrane Collaboration, Copenhagen, Denmark) was used to analyze all data of this study. The Cochrane risk bias assessment tool is a risk bias evaluation criterion recommended by the Cochrane Handbook for systematic reviews.</p><p><strong>Results: </strong>Eleven studies involving 1268 knees in total were included. The main outcome indexes showed that the Knee Society Score (KSS) knee score (MD: -1.40; 95% CI: -2.57 to -0.22; p = 0.02) and KSS knee function score (MD: -3.11; 95% CI: -3.72 to -2.50; p < 0.001) in the GB group were higher 1 year after operation, while femoral component rotation angle (FCRA; MD: -0.75; 95% CI: -1.34 to -0.07; p = 0.03) and the osteotomy volume of the posterior medial femoral condyle (MD: -0.76; 95% CI; -1.13 to -0.38; p < 0.001) were greater in the GB group. In addition, there was no significant difference in the joint line change (MD: -0.03; 95% CI: -0.07 to 0.01; p = 0.16) between the two groups. Secondary outcome results showed that the knee joint range of motion (ROM) in 3 months, and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score after 1 year were better in the GB group. However, the operation time of the MR group was shorter. In addition, this study revealed no significant differences in post-complications between these two groups.</p><p><strong>Conclusion: </strong>Although the GB technique may not provide better radiographic results or reduce the complication rate, the recovery of joint function showed earlier improvement.</p>","PeriodicalId":51219,"journal":{"name":"Zeitschrift Fur Orthopadie Und Unfallchirurgie","volume":" ","pages":"391-402"},"PeriodicalIF":1.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9881625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Instabilities and Osteoarthritis of the Sternoclavicular Joint. 胸锁关节的不稳定性和骨关节炎。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-01 Epub Date: 2023-08-30 DOI: 10.1055/a-2109-3190
Johannes E Plath, Frank Martetschläger, Philipp Moroder, Gunther Sandmann

Injury to the sternoclavicular joint (SCG) is very rare, accounting for 3% of shoulder injuries and < 1% of instabilities. Consequently, both the treatment of acute instabilities and their subsequent states (chronic instabilities/SCG arthrosis) are controversial. While treatment has so far been mostly conservative, in recent years there has been a trend towards surgical therapy.Considerable violence, such as that found in traffic accidents or contact sports, can tear the extremely stable ligaments between the medial clavicle and sternum. While anterior dislocation is easier to reduce in most cases, instability remains in up to 50% of cases. In most cases, posterior instability requires rapid reduction, particularly due to the anatomical proximity to important cardio-pulmonary structures. If this succeeds, the rate of persistent instabilities is low. For chronic instability, reconstruction/augmentation of the ligament apparatus with tendon grafts in the "Figure of 8 configuration" has proven to be the standard technique in recent years.

胸锁关节(SCG)损伤非常罕见,仅占肩部损伤的 3%,并且
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引用次数: 0
期刊
Zeitschrift Fur Orthopadie Und Unfallchirurgie
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