Pub Date : 2024-05-07DOI: 10.25259/ijdvl_1201_2023
A. Agrawal, Maninder Kaur, A. Bains, Taruna Yadav, S. Patra
{"title":"Mixed lymphatic malformation of tongue in a child with excellent response to oral sirolimus","authors":"A. Agrawal, Maninder Kaur, A. Bains, Taruna Yadav, S. Patra","doi":"10.25259/ijdvl_1201_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1201_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"87 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.25259/ijdvl_1069_2023
H. Mehta, Keshavamurthy Vinay, A. Bishnoi, Anish Thind, Naresh Nagrath, Sunil Dogra, D. Parsad, M. Kumaran
{"title":"Misaligned teeth as a contributory mechanism in lip vitiligo","authors":"H. Mehta, Keshavamurthy Vinay, A. Bishnoi, Anish Thind, Naresh Nagrath, Sunil Dogra, D. Parsad, M. Kumaran","doi":"10.25259/ijdvl_1069_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1069_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"59 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141009670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.25259/ijdvl_1269_2023
A. Mohta, Rashmi Sarkar
{"title":"Lacosamide-induced haemorrhagic onychomadesis with ‘rising sun appearance’","authors":"A. Mohta, Rashmi Sarkar","doi":"10.25259/ijdvl_1269_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1269_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"320 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141006772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-06DOI: 10.25259/ijdvl_1413_2023
B. Behera
{"title":"Vermilion: An underemphasised anatomical area in dermatology","authors":"B. Behera","doi":"10.25259/ijdvl_1413_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1413_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"37 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141007639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhawuk Dhir, Surabhi Sinha, K. Sardana, Priyanka Goutam, Arvind Ahuja
{"title":"Concurrent pyoderma gangrenosum and tuberculosis: Diagnosis, treatment complexities and exploring cyclosporine’s role – A literature review","authors":"Bhawuk Dhir, Surabhi Sinha, K. Sardana, Priyanka Goutam, Arvind Ahuja","doi":"10.25259/ijdvl_637_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_637_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141007456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lues maligna with neurosyphilis presenting in a diabetic, HIV-negative man","authors":"Yujun Wang, Yipei Yuan, Shengxiang Xiao, Longfei Zhu","doi":"10.25259/ijdvl_1362_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1362_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"34 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141010641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An unusual case of periumbilical discolouration – Cullen’s sign","authors":"Suhail M K Khan, Shilpa Kanathur","doi":"10.25259/ijdvl_258_2024","DOIUrl":"https://doi.org/10.25259/ijdvl_258_2024","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"47 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141010300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis is a common chronic inflammatory disorder affecting all aspects of a patient’s life. Nail involvement is frequent, but little is known about its associated inflammatory biomarker profile, including similarities or differences from cutaneous disease. We conducted this cross-sectional study to evaluate serum levels of inflammatory cytokines [tumour necrosis factor-alpha (TNF-α) and interleukin -17 (IL-17)] in patients with nail psoriasis and compared these to psoriasis patients without nail involvement, as well as in non-psoriatic healthy controls. Adult psoriasis patients with (Group I, n = 30) and without nail involvement (Group-II, n = 30) were sequentially recruited. In addition, non-psoriatic healthy controls (Group-III, n = 20) were recruited. The nail disease severity by NAPSI score was determined for patients in Group I. Cutaneous disease severity (by PASI score) and presence of psoriatic arthritis (through CASPAR criteria) were evaluated for patients in Groups I and II. Serum levels of TNF-α, IL-17, erythrocyte sedimentation rate (ESR), rheumatoid factor (RA factor), and anti-cyclic citrullinated peptide antibody (Anti-CCP) were evaluated for all three groups. The median age was significantly higher for Group I as compared to Group II patients (41 ± 12.6 years vs 30 ± 12.4 years, p = 0.017). Group I patients also had higher median PASI score than Group II patients, although the difference was not statistically significant (10 ± 11.41 vs 6.50 ± 5.46, p = 0.275). The mean serum IL-17 levels were significantly higher for Group-I (113.39 ± 251.30 pg/mL) than Group II (27.91 ± 18.22 pg/mL, p = 0.002) and Group III (25.67 ± 12.08 pg/mL, p = 0.005). A weak positive correlation was found between NAPSI and serum IL-17 levels (Spearman’s Rho = 0.355) though not statistically significant (p = 0.054). Correlation between serum IL-17 and PASI was poor for Group-I patients (Spearman’s Rho = 0.13, p = 0.944) and strongly negative for Group-II patients (Spearman’s Rho = −0.368, statistically significant with p = 0.045). The mean serum levels of TNF-α were below the detection threshold of the assay kit, hence no meaningful comparison could be made. A small sample size and low sensitivity of TNF-α assay kit. Our study showed that nail psoriasis could be independently associated with an elevation of IL-17. This can help choose appropriate drugs and estimate drug response in patients with nail psoriasis.
银屑病是一种常见的慢性炎症性疾病，影响患者生活的方方面面。指甲经常受累，但人们对其相关的炎症生物标志物谱却知之甚少，包括与皮肤病的异同。我们进行了这项横断面研究，以评估指甲银屑病患者血清中的炎症细胞因子[肿瘤坏死因子-α（TNF-α）和白细胞介素-17（IL-17）]水平，并与未受累指甲的银屑病患者以及非银屑病健康对照组进行比较。此外，还招募了非银屑病健康对照组（第三组，n = 20）。根据 NAPSI 评分确定 I 组患者的指甲疾病严重程度，并根据 CASPAR 标准评估 I 组和 II 组患者的皮肤疾病严重程度（根据 PASI 评分）和银屑病关节炎的存在情况。对所有三组患者的血清 TNF-α、IL-17、红细胞沉降率（ESR）、类风湿因子（RA因子）和抗环瓜氨酸肽抗体（Anti-CCP）水平进行了评估。I 组患者的中位年龄明显高于 II 组患者（41 ± 12.6 岁 vs 30 ± 12.4 岁，P = 0.017）。I 组患者的 PASI 评分中位数也高于 II 组患者，但差异无统计学意义（10 ± 11.41 vs 6.50 ± 5.46，P = 0.275）。I 组患者的平均血清 IL-17 水平（113.39 ± 251.30 pg/mL）明显高于 II 组（27.91 ± 18.22 pg/mL，p = 0.002）和 III 组（25.67 ± 12.08 pg/mL，p = 0.005）。NAPSI 与血清 IL-17 水平之间存在微弱的正相关（Spearman's Rho = 0.355），但无统计学意义（p = 0.054）。I 组患者血清 IL-17 与 PASI 之间的相关性较差（Spearman's Rho = 0.13，p = 0.944），II 组患者则呈强烈负相关（Spearman's Rho = -0.368，有统计学意义，p = 0.045）。我们的研究表明，指甲银屑病与 IL-17 的升高有独立关联。我们的研究表明，指甲银屑病与IL-17的升高有独立关联，这有助于选择合适的药物和估计指甲银屑病患者对药物的反应。
{"title":"Serum levels of tumour necrosis factor (TNF-α) and interleukin-17 (IL-17) in patients with nail psoriasis: A cross-sectional study","authors":"Anil Kumar Bhoi, C. Grover, Archana Singal, Bineeta Kashyap, Dibyashree Dibyashree","doi":"10.25259/ijdvl_367_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_367_2023","url":null,"abstract":"\u0000\u0000Psoriasis is a common chronic inflammatory disorder affecting all aspects of a patient’s life. Nail involvement is frequent, but little is known about its associated inflammatory biomarker profile, including similarities or differences from cutaneous disease.\u0000\u0000\u0000\u0000We conducted this cross-sectional study to evaluate serum levels of inflammatory cytokines [tumour necrosis factor-alpha (TNF-α) and interleukin -17 (IL-17)] in patients with nail psoriasis and compared these to psoriasis patients without nail involvement, as well as in non-psoriatic healthy controls.\u0000\u0000\u0000\u0000Adult psoriasis patients with (Group I, n = 30) and without nail involvement (Group-II, n = 30) were sequentially recruited. In addition, non-psoriatic healthy controls (Group-III, n = 20) were recruited. The nail disease severity by NAPSI score was determined for patients in Group I. Cutaneous disease severity (by PASI score) and presence of psoriatic arthritis (through CASPAR criteria) were evaluated for patients in Groups I and II. Serum levels of TNF-α, IL-17, erythrocyte sedimentation rate (ESR), rheumatoid factor (RA factor), and anti-cyclic citrullinated peptide antibody (Anti-CCP) were evaluated for all three groups.\u0000\u0000\u0000\u0000The median age was significantly higher for Group I as compared to Group II patients (41 ± 12.6 years vs 30 ± 12.4 years, p = 0.017). Group I patients also had higher median PASI score than Group II patients, although the difference was not statistically significant (10 ± 11.41 vs 6.50 ± 5.46, p = 0.275). The mean serum IL-17 levels were significantly higher for Group-I (113.39 ± 251.30 pg/mL) than Group II (27.91 ± 18.22 pg/mL, p = 0.002) and Group III (25.67 ± 12.08 pg/mL, p = 0.005). A weak positive correlation was found between NAPSI and serum IL-17 levels (Spearman’s Rho = 0.355) though not statistically significant (p = 0.054). Correlation between serum IL-17 and PASI was poor for Group-I patients (Spearman’s Rho = 0.13, p = 0.944) and strongly negative for Group-II patients (Spearman’s Rho = −0.368, statistically significant with p = 0.045). The mean serum levels of TNF-α were below the detection threshold of the assay kit, hence no meaningful comparison could be made.\u0000\u0000\u0000\u0000A small sample size and low sensitivity of TNF-α assay kit.\u0000\u0000\u0000\u0000Our study showed that nail psoriasis could be independently associated with an elevation of IL-17. This can help choose appropriate drugs and estimate drug response in patients with nail psoriasis. \u0000","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hailey–Hailey disease (HHD) is a rare, autosomal dominant, hereditary skin disorder characterised by epidermal acantholysis. The HHD-associated gene ATPase calcium-transporting type 2C member 1 (ATP2C1) encodes the protein secretory pathway Ca2+ ATPase1 (SPCA1), playing a critical role in HHD pathogenesis. We aimed to investigate the effect of ATP2C1 knockdown on keratinocytes that mimicked acantholysis in HHD. Immunohistochemistry (IHC) was employed to evaluate the levels of cytoskeletal and tight junction proteins such as SPCA1, P-cofilin, F-actin, claudins, occludin, and zonula occludens 1 in the skin biopsies of patients with HHD. Subsequently, the expression of these proteins in cultured ATP2C1 knockdown keratinocytes was analysed using Western blotting and immunofluorescence. Furthermore, we assessed the proliferation, apoptosis, and intracellular Ca2+ concentrations in the ATP2C1-knocked keratinocytes. The results showed decreased levels of these proteins (SPCA1, P-cofilin, F-actin, claudins, occluding, and zonula occludens 1) in HHD skin lesions. Moreover, their levels decreased in human keratinocytes transfected with ATP2C1 short hairpin RNA, accompanied by morphological acantholysis. Furthermore, the proliferation and apoptosis of the keratinocytes, as well as intracellular calcium concentrations in these cells, were not affected. The limitations of this study are the absence of animal experiments and the failure to explore the relationship between skeletal and tight junction proteins. The present study indicated that ATP2C1 inhibition led to abnormal levels of the cytoskeletal and tight junction proteins in the keratinocytes. Therefore, keratinocytes can mimic HHD-like acantholysis and serve as an in vitro model, helping develop treatment strategies against HHD.
海利-海利病（Hailey-Hailey disease，HHD）是一种罕见的常染色体显性遗传性皮肤病，以表皮棘层溶解为特征。HHD相关基因ATPase calcium-transporting type 2C member 1（ATP2C1）编码蛋白分泌途径Ca2+ ATPase1（SPCA1），在HHD发病机制中起着关键作用。我们采用免疫组织化学（IHC）方法评估了HHD患者皮肤活检组织中细胞骨架和紧密连接蛋白的水平，如SPCA1、P-cofilin、F-actin、claudins、occludin和zonula occludens 1。随后，我们使用 Western 印迹法和免疫荧光法分析了这些蛋白在培养的 ATP2C1 敲除角质形成细胞中的表达情况。结果显示，这些蛋白质（SPCA1、P-cofilin、F-actin、claudins、occluding 和 zonula occludens 1）的水平在 HHD 皮肤病变中有所下降。此外，在转染了 ATP2C1 短发夹核糖核酸的人类角质细胞中，这些蛋白的水平也有所下降，并伴有形态学上的棘层溶解。本研究的局限性在于没有进行动物实验，也没有探讨骨骼蛋白和紧密连接蛋白之间的关系。因此，角朊细胞可以模拟HHD样棘层溶解，并作为体外模型，帮助开发针对HHD的治疗策略。
{"title":"ATP2C1 knockdown induces abnormal expressions of cytoskeletal and tight junction proteins mimicking Hailey–Hailey disease","authors":"Mingzhu Zhou, Shiran Kang, Yumin Xia, Dingwei Zhang, Wenwen Chen","doi":"10.25259/ijdvl_853_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_853_2023","url":null,"abstract":"\u0000\u0000Hailey–Hailey disease (HHD) is a rare, autosomal dominant, hereditary skin disorder characterised by epidermal acantholysis. The HHD-associated gene ATPase calcium-transporting type 2C member 1 (ATP2C1) encodes the protein secretory pathway Ca2+ ATPase1 (SPCA1), playing a critical role in HHD pathogenesis.\u0000\u0000\u0000\u0000We aimed to investigate the effect of ATP2C1 knockdown on keratinocytes that mimicked acantholysis in HHD. \u0000\u0000\u0000\u0000Immunohistochemistry (IHC) was employed to evaluate the levels of cytoskeletal and tight junction proteins such as SPCA1, P-cofilin, F-actin, claudins, occludin, and zonula occludens 1 in the skin biopsies of patients with HHD. Subsequently, the expression of these proteins in cultured ATP2C1 knockdown keratinocytes was analysed using Western blotting and immunofluorescence. Furthermore, we assessed the proliferation, apoptosis, and intracellular Ca2+ concentrations in the ATP2C1-knocked keratinocytes.\u0000\u0000\u0000\u0000The results showed decreased levels of these proteins (SPCA1, P-cofilin, F-actin, claudins, occluding, and zonula occludens 1) in HHD skin lesions. Moreover, their levels decreased in human keratinocytes transfected with ATP2C1 short hairpin RNA, accompanied by morphological acantholysis. Furthermore, the proliferation and apoptosis of the keratinocytes, as well as intracellular calcium concentrations in these cells, were not affected.\u0000\u0000\u0000\u0000The limitations of this study are the absence of animal experiments and the failure to explore the relationship between skeletal and tight junction proteins.\u0000\u0000\u0000\u0000The present study indicated that ATP2C1 inhibition led to abnormal levels of the cytoskeletal and tight junction proteins in the keratinocytes. Therefore, keratinocytes can mimic HHD-like acantholysis and serve as an in vitro model, helping develop treatment strategies against HHD.\u0000","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.25259/ijdvl_1102_2023
Kanya Rani Vashisht, Richa Gupta, Priyadarshini Sahu, P. Mandula, Nabaneeta Dash, Anil Eragam, Biman Saikia, Amit Agarwal
{"title":"Managing outbreak of community-onset paediatric impetigo in underserved areas of North India via teledermatology: A tertiary care centre’s experience","authors":"Kanya Rani Vashisht, Richa Gupta, Priyadarshini Sahu, P. Mandula, Nabaneeta Dash, Anil Eragam, Biman Saikia, Amit Agarwal","doi":"10.25259/ijdvl_1102_2023","DOIUrl":"https://doi.org/10.25259/ijdvl_1102_2023","url":null,"abstract":"","PeriodicalId":513160,"journal":{"name":"Indian Journal of Dermatology, Venereology and Leprology","volume":"9 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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