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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain 伊塔康酸 4-辛酯可抑制创伤后骨关节炎小鼠模型中的滑膜炎并减轻疼痛。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 DOI: 10.1016/j.cjtee.2024.10.001
Yu-Zhen Tang , Wan Chen , Bao-Yun Xu , Gang He , Xiu-Cheng Fan , Kang-Lai Tang
<div><h3>Purpose</h3><div>To investigate the pathological changes of the synovium in mice with post-traumatic osteoarthritis (PTOA) treated with 4-octyl itaconate (4-OI) and evaluate the therapeutic effects of 4-OI.</div></div><div><h3>Methods</h3><div>In the phenotypic validation experiment, the mice were randomly divided into 3 groups: wild-type (WT) group, sham group, and destabilization of the medial meniscus (DMM) group. Through MRI, micro-CT, and histological analysis, it was determined that the DMM surgery induced a mouse PTOA model with significant signs of synovitis. At 12 weeks post-DMM surgery, synovial tissues from the DMM group and WT group mice were collected for ribonucleic acid sequencing analysis. In the 4-OI treatment experiment, mice were randomly divided into the sham group, DMM group, DMM + 4-OI (50 mg/kg) group, and DMM + 4-OI (100 mg/kg) group. Von Frey tests and open field tests were conducted at intervals during the 12 weeks following the DMM surgery. After 12 weeks of surgery, the efficacy of 4-OI treatment on PTOA in mice was evaluated using MRI, micro-CT, histological analysis, and quantitative real-time polymerase chain reaction. Finally, we utilized network pharmacology analysis to predict the mechanism of 4-OI in treating PTOA synovitis and conducted preliminary validation. Statistical analysis was performed using one-way ANOVA and the Kruskal-Wallis test. Difference was considered statistically significant at <em>p</em> < 0.05.</div></div><div><h3>Results</h3><div>The DMM surgery effectively induced a PTOA mouse model, which displayed significant symptoms of synovitis. These symptoms included a notable increase in both the number of calcified tissues and osteophytes (<em>p</em> < 0.001), an enlargement of the calcified meniscus and synovial tissue volume (<em>p</em> < 0.001), and thickening of the synovial lining layer attributable to M1 macrophage accumulation (<em>p</em> = 0.035). Additionally, we observed elevated histological scores for synovitis (<em>p</em> < 0.001). Treatment with 4-OI inhibited the thickening of M1 macrophages in the synovial lining layer of PTOA mice (<em>p</em> < 0.001) and reduced fibrosis in the synovial stroma (<em>p</em> = 0.004). Furthermore, it reduced the histological scores of knee synovitis in PTOA mice (<em>p</em> = 0.006) and improved the inflammatory microenvironment associated with synovitis. Consequently, this treatment alleviated pain in PTOA mice (<em>p</em> < 0.001) and reduced spontaneous activity (<em>p</em> = 0.003). Bioinformatics and network pharmacology analyses indicated that 4-OI may exert its therapeutic effects by inhibiting the differentiation of synovial Th17 cells. Specifically, compared to the lipopolysaccharide stimulation group, 4-OI reduced the levels of positive regulatory factors of Th17 cell differentiation (IL-1: <em>p</em> < 0.001, IL-6: <em>p</em> < 0.001), key effector molecules (IL-17A: <em>p</em> < 0.001, IL-17F: <em>p</
目的:研究使用伊他康酸 4-辛酯(4-OI)治疗创伤后骨关节炎(PTOA)小鼠滑膜的病理变化,并评估 4-OI 的治疗效果:在表型验证实验中,小鼠被随机分为三组:野生型(WT)组、假组和内侧半月板失稳(DMM)组。通过核磁共振成像、显微 CT 和组织学分析,确定 DMM 手术诱导的小鼠 PTOA 模型有明显的滑膜炎症状。在 DMM 手术后 12 周,收集 DMM 组和 WT 组小鼠的滑膜组织进行核糖核酸测序分析。在 4-OI 治疗实验中,小鼠被随机分为假组、DMM 组、DMM + 4-OI (50 mg/kg) 组和 DMM + 4-OI (100 mg/kg) 组。在 DMM 手术后的 12 周内,每隔一段时间进行一次 Von Frey 试验和野外开放试验。手术 12 周后,我们使用 MRI、Micro-CT、组织学分析和定量实时 PCR 评估了 4-OI 治疗对小鼠 PTOA 的疗效。最后,我们利用网络药理学分析预测了 4-OI 治疗 PTOA 滑膜炎的机制,并进行了初步验证。统计分析采用单因素方差分析和 Kruskal-Wallis 检验:结果:DMM手术有效地诱导了PTOA小鼠模型,该模型出现了明显的滑膜炎症状。这些症状包括钙化组织和骨质增生的数量明显增加(p 结论:4-OI 能有效抑制滑膜炎的发生:4-OI 能有效抑制 PTOA 的滑膜炎,从而减轻相关的疼痛症状。
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引用次数: 0
Recent advances in the management of chronic ankle instability 慢性踝关节不稳定治疗的最新进展。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 DOI: 10.1016/j.cjtee.2024.07.011
Yimeng Yang, Yang Wu, Wenhui Zhu
Ankle sprains are the most common lesion of the ankle joint which might result in chronic ankle instability (CAI). Significant strides have been taken to enhance our comprehension of the underlying mechanisms of CAI, as the exploration of novel surgical techniques and the identification of previously unrecognized anatomical components. The present review aims to provide an extensive overview of CAI, encompassing its pathophysiology, epidemiology, clinical assessment, treatment, and rehabilitation. Treatment of CAI requires a multifaceted algorithm, involving historical analysis, clinical evaluations, and diagnostic imaging. Surgical interventions for CAI primarily involve the anatomical and/or non-anatomical reconstruction and/or repair of the anterior talofibular ligament. Anatomical repair has exhibited superior functional outcomes and a reduced risk of secondary osteoarthritis compared to non-anatomical repair. Non-anatomical approaches fall short of replicating the normal biomechanics of the anterior talofibular ligament, potentially leading to postoperative stiffness. This review seeks to academically review and up-to-date literature on this issue, tailored for clinical practice, with the intent of aiding surgeons in staying abreast of this critical subject matter.
踝关节扭伤是踝关节最常见的损伤,可能导致慢性踝关节不稳定(CAI)。随着对新型手术技术的探索和对以前未曾认识到的解剖学成分的识别,我们对 CAI 潜在机制的理解有了长足的进步。本综述旨在广泛概述 CAI,包括其病理生理学、流行病学、临床评估、治疗和康复。CAI 的治疗需要多方面的算法,包括历史分析、临床评估和影像诊断。CAI 的手术干预主要涉及解剖和/或非解剖重建和/或修复距骨胫骨前韧带。与非解剖性修复相比,解剖性修复的功能效果更好,继发性骨关节炎的风险也更低。非解剖方法无法复制距骨胫骨前韧带的正常生物力学,可能导致术后僵硬。本综述旨在对这一问题的最新文献进行学术回顾,为临床实践量身定制,目的是帮助外科医生了解这一关键主题。
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引用次数: 0
YOLOX-SwinT algorithm improves the accuracy of AO/OTA classification of intertrochanteric fractures by orthopedic trauma surgeons YOLOX-SwinT 算法提高了创伤骨科医生对转子间骨折进行 AO/OTA 分类的准确性
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 DOI: 10.1016/j.cjtee.2024.04.002
Xue-Si Liu , Rui Nie , Ao-Wen Duan , Li Yang , Xiang Li , Le-Tian Zhang , Guang-Kuo Guo , Qing-Shan Guo , Dong-Chu Zhao , Yang Li , He-Hua Zhang

Purpose

Intertrochanteric fracture (ITF) classification is crucial for surgical decision-making. However, orthopedic trauma surgeons have shown lower accuracy in ITF classification than expected. The objective of this study was to utilize an artificial intelligence (AI) method to improve the accuracy of ITF classification.

Methods

We trained a network called YOLOX-SwinT, which is based on the You Only Look Once X (YOLOX) object detection network with Swin Transformer (SwinT) as the backbone architecture, using 762 radiographic ITF examinations as the training set. Subsequently, we recruited 5 senior orthopedic trauma surgeons (SOTS) and 5 junior orthopedic trauma surgeons (JOTS) to classify the 85 original images in the test set, as well as the images with the prediction results of the network model in sequence. Statistical analysis was performed using the SPSS 20.0 (IBM Corp., Armonk, NY, USA) to compare the differences among the SOTS, JOTS, SOTS + AI, JOTS + AI, SOTS + JOTS, and SOTS + JOTS + AI groups. All images were classified according to the AO/OTA 2018 classification system by 2 experienced trauma surgeons and verified by another expert in this field. Based on the actual clinical needs, after discussion, we integrated 8 subgroups into 5 new subgroups, and the dataset was divided into training, validation, and test sets by the ratio of 8:1:1.

Results

The mean average precision at the intersection over union (IoU) of 0.5 (mAP50) for subgroup detection reached 90.29%. The classification accuracy values of SOTS, JOTS, SOTS + AI, and JOTS + AI groups were 56.24% ± 4.02%, 35.29% ± 18.07%, 79.53% ± 7.14%, and 71.53% ± 5.22%, respectively. The paired t-test results showed that the difference between the SOTS and SOTS + AI groups was statistically significant, as well as the difference between the JOTS and JOTS + AI groups, and the SOTS + JOTS and SOTS + JOTS + AI groups. Moreover, the difference between the SOTS + JOTS and SOTS + JOTS + AI groups in each subgroup was statistically significant, with all p < 0.05. The independent samples t-test results showed that the difference between the SOTS and JOTS groups was statistically significant, while the difference between the SOTS + AI and JOTS + AI groups was not statistically significant. With the assistance of AI, the subgroup classification accuracy of both SOTS and JOTS was significantly improved, and JOTS achieved the same level as SOTS.

Conclusion

In conclusion, the YOLOX-SwinT network algorithm enhances the accuracy of AO/OTA subgroups classification of ITF by orthopedic trauma surgeons.
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引用次数: 0
Two cases of complex traumatic aortic dissection combined with multiple organ injuries 两例复杂的外伤性主动脉夹层合并多器官损伤。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 DOI: 10.1016/j.cjtee.2024.08.001
Qingpeng Song, Lili Bao, Xuejun Wu, Bingqi Liu, Maohua Wang
Traumatic aortic injury (TAI) is an acute, critical, and severe disease, and then combined with multiple organ damage, it is even more dangerous. TAI progresses very rapidly, with a pre-hospital mortality rate of 57%–80%, and even when arriving at the hospital, more than one-third of the patients die within 4 h, and it is the 2nd leading cause of death in individuals aged 4−34 years. In addition, the incidence of TAI combined with injury was 81.4%. Therefore, early diagnosis, expeditious surgery, and timely and effective multidisciplinary cooperation are essential for successful rescue. The authors report 2 patients with acute traumatic aortic dissection combined with multiple organ injuries and treated with emergency endovascular surgery to discuss their clinical characteristics and treatment experience, and to provide experience in the diagnosis and treatment of such patients.
创伤性主动脉损伤(TAI)是一种急性、危重的严重疾病,再加上多器官损伤,就更加危险了。创伤性主动脉损伤进展非常迅速,院前死亡率高达 57% - 80%,即使到达医院,也有超过三分之一的患者在 4 小时内死亡,是 4 - 34 岁人群的第二大死因。此外,TAI合并损伤的发生率为81.4%。因此,早期诊断、快速手术、及时有效的多学科合作是成功抢救的关键。作者报告了2例急性创伤性主动脉夹层合并多脏器损伤并接受急诊血管内手术治疗的患者,探讨其临床特点和治疗经验,为此类患者的诊断和治疗提供经验。
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引用次数: 0
Corrigendum to "Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3" [Chinese J Traumatol 22 (2019) 161-165]. 右美托咪定通过抑制NLRP3降低手术损伤诱导的海马小胶质细胞炎症反应[J].中华创伤杂志22(2019)161-165。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2024-12-28 DOI: 10.1016/j.cjtee.2024.12.001
Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Yan
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引用次数: 0
Protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on a yorkshire model of brain injury after traumatic blood loss. 亚低温机械灌注联合膜肺氧合对创伤性失血脑损伤约克郡模型的保护作用。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2024-12-22 DOI: 10.1016/j.cjtee.2024.10.003
Xiang-Yu Song, Yang-Hui Dong, Zhi-Bo Jia, Lei-Jia Chen, Meng-Yi Cui, Yan-Jun Guan, Bo-Yao Yang, Si-Ce Wang, Sheng-Feng Chen, Peng-Kai Li, Heng Chen, Hao-Chen Zuo, Zhan-Cheng Yang, Wen-Jing Xu, Ya-Qun Zhao, Jiang Peng
<p><strong>Purpose: </strong>To investigate the protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on ischemic hypoxic injury of yorkshire brain tissue caused by traumatic blood loss.</p><p><strong>Methods: </strong>This article performed a random controlled trial. Brain tissue of 7 yorkshire was selected and divided into the sub-low temperature anterograde machine perfusion group (n = 4) and the blank control group (n = 3) using the random number table method. A yorkshire model of brain tissue injury induced by traumatic blood loss was established. Firstly, the perfusion temperature and blood oxygen saturation were monitored in real-time during the perfusion process. The number of red blood cells, hemoglobin content, NA<sup>+</sup>, K<sup>+</sup>, and Ca<sup>2+</sup> ions concentrations and pH of the perfusate were detected. Following perfusion, we specifically examined the parietal lobe to assess its water content. The prefrontal cortex and hippocampus were then dissected for histological evaluation, allowing us to investigate potential regional differences in tissue injury. The blank control group was sampled directly before perfusion. All statistical analyses and graphs were performed using GraphPad Prism 8.0 Student t-test. All tests were two-sided, and p value of less than 0.05 was considered to indicate statistical significance.</p><p><strong>Results: </strong>The contents of red blood cells and hemoglobin during perfusion were maintained at normal levels but more red blood cells were destroyed 3 h after the perfusion. The blood oxygen saturation of the perfusion group was maintained at 95% - 98%. NA<sup>+</sup> and K<sup>+</sup> concentrations were normal most of the time during perfusion but increased significantly at about 4 h. The Ca<sup>2+</sup> concentration remained within the normal range at each period. Glucose levels were slightly higher than the baseline level. The pH of the perfusion solution was slightly lower at the beginning of perfusion, and then gradually increased to the normal level. The water content of brain tissue in the sub-low and docile perfusion group was 78.95% ± 0.39%, which was significantly higher than that in the control group (75.27% ± 0.55%, t = 10.49, p < 0.001), and the difference was statistically significant. Compared with the blank control group, the structure and morphology of pyramidal neurons in the Prefrontal cortex and CA1 region of the hippocampal gyrus were similar, and their integrity was better. The structural integrity of granulosa neurons was destroyed and cell edema increased in the perfusion group compared with the blank control group. Immunofluorescence staining for glail fibrillary acidic protein and Iba1, markers of glial cells, revealed well-preserved cell structures in the perfusion group. While there were indications of abnormal cellular activity, the analysis showed no significant difference in axon thickness or integrity compared to th
目的:探讨亚低温机械灌注联合膜肺氧合对外伤性失血所致约克郡脑组织缺血性缺氧损伤的保护作用。方法:采用随机对照试验。选取7只大约克羊脑组织,采用随机数字表法分为亚低温顺行机灌注组(n = 4)和空白对照组(n = 3)。建立外伤性失血致脑组织损伤约克郡模型。首先,实时监测灌注过程中的灌注温度和血氧饱和度。检测灌注液红细胞数量、血红蛋白含量、NA+、K+、Ca2+离子浓度及pH值。灌注后,我们专门检查顶叶以评估其含水量。然后解剖前额叶皮层和海马体进行组织学评估,使我们能够研究组织损伤的潜在区域差异。空白对照组在灌注前直接取样。所有统计分析和图表均采用GraphPad Prism 8.0学生t检验。所有检验均为双侧检验,p值小于0.05为有统计学意义。结果:灌注时红细胞和血红蛋白含量维持在正常水平,但灌注后3 h红细胞破坏较多。灌注组血氧饱和度维持在95% ~ 98%。NA+和K+浓度在灌注期间大部分时间正常,但在4 h左右显著升高。Ca2+浓度在各时期保持在正常范围内。血糖水平略高于基线水平。灌注液的pH值在灌注开始时略低,然后逐渐升高至正常水平。亚低温和温和灌注组脑组织含水量为78.95%±0.39%,显著高于对照组(75.27%±0.55%),t = 10.49, p结论:亚低温机灌注可通过持续供氧,维持离子稳态,降低组织代谢水平,改善外伤性失血引起的约克郡脑组织缺血缺氧损伤,延缓约克郡脑组织坏死和凋亡。
{"title":"Protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on a yorkshire model of brain injury after traumatic blood loss.","authors":"Xiang-Yu Song, Yang-Hui Dong, Zhi-Bo Jia, Lei-Jia Chen, Meng-Yi Cui, Yan-Jun Guan, Bo-Yao Yang, Si-Ce Wang, Sheng-Feng Chen, Peng-Kai Li, Heng Chen, Hao-Chen Zuo, Zhan-Cheng Yang, Wen-Jing Xu, Ya-Qun Zhao, Jiang Peng","doi":"10.1016/j.cjtee.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.cjtee.2024.10.003","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To investigate the protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on ischemic hypoxic injury of yorkshire brain tissue caused by traumatic blood loss.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This article performed a random controlled trial. Brain tissue of 7 yorkshire was selected and divided into the sub-low temperature anterograde machine perfusion group (n = 4) and the blank control group (n = 3) using the random number table method. A yorkshire model of brain tissue injury induced by traumatic blood loss was established. Firstly, the perfusion temperature and blood oxygen saturation were monitored in real-time during the perfusion process. The number of red blood cells, hemoglobin content, NA&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt;, and Ca&lt;sup&gt;2+&lt;/sup&gt; ions concentrations and pH of the perfusate were detected. Following perfusion, we specifically examined the parietal lobe to assess its water content. The prefrontal cortex and hippocampus were then dissected for histological evaluation, allowing us to investigate potential regional differences in tissue injury. The blank control group was sampled directly before perfusion. All statistical analyses and graphs were performed using GraphPad Prism 8.0 Student t-test. All tests were two-sided, and p value of less than 0.05 was considered to indicate statistical significance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The contents of red blood cells and hemoglobin during perfusion were maintained at normal levels but more red blood cells were destroyed 3 h after the perfusion. The blood oxygen saturation of the perfusion group was maintained at 95% - 98%. NA&lt;sup&gt;+&lt;/sup&gt; and K&lt;sup&gt;+&lt;/sup&gt; concentrations were normal most of the time during perfusion but increased significantly at about 4 h. The Ca&lt;sup&gt;2+&lt;/sup&gt; concentration remained within the normal range at each period. Glucose levels were slightly higher than the baseline level. The pH of the perfusion solution was slightly lower at the beginning of perfusion, and then gradually increased to the normal level. The water content of brain tissue in the sub-low and docile perfusion group was 78.95% ± 0.39%, which was significantly higher than that in the control group (75.27% ± 0.55%, t = 10.49, p &lt; 0.001), and the difference was statistically significant. Compared with the blank control group, the structure and morphology of pyramidal neurons in the Prefrontal cortex and CA1 region of the hippocampal gyrus were similar, and their integrity was better. The structural integrity of granulosa neurons was destroyed and cell edema increased in the perfusion group compared with the blank control group. Immunofluorescence staining for glail fibrillary acidic protein and Iba1, markers of glial cells, revealed well-preserved cell structures in the perfusion group. While there were indications of abnormal cellular activity, the analysis showed no significant difference in axon thickness or integrity compared to th","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total laparoscopic closed reduction and internal fixation for AO/OTA B2.1 pelvic fracture: A case report and literature review. 全腹腔镜闭合复位和内固定治疗 AO/OTA B2.1 骨盆骨折:病例报告和文献综述。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2024-12-11 DOI: 10.1016/j.cjtee.2024.10.002
Huanyu Shi, Xiao Zhong, Yan Wang, Wei Chen, Hao Tan, Wanfei Wu, Lianyang Zhang, Yang Li

Endoscopic techniques have been widely used in orthopedic surgery, such as arthroscopy and transforaminal endoscopy, but the application in fracture is rarely reported. We reported a case of a 69-year-old male with pelvic fracture (AO/OTA type B2.1) who underwent successful laparoscopy-assisted pubic ramus plate fixation without auxiliary incision. We designed and applied a separate custom-made lengthening surgical instrument for internal fixation installation suitable for laparoscopic surgery, and the entire reduction and internal fixation installation were performed under laparoscopy. The patient could sit up 1 day after surgery, and the reported pain visual analogue scale score decreased from 5 points before surgery to 1 point. At 2 weeks after surgery, the patient could walk with a single crutch. At 4 weeks after surgery, the Majeed score was 73 points, and at 10 weeks after surgery, the Majeed score increased to 81 points. Twelve weeks after surgery, the patient was able to walk independently without pain, defecation and urination function, and the Majeed score was 87. Laparoscopic surgery is a new strategy for treating pelvic ring fractures. The case proves that full laparoscopic-assisted closed reduction and internal fixation of pelvic fractures is feasible.

内窥镜技术已广泛应用于骨科手术,如关节镜、椎间孔内窥镜等,但在骨折中的应用鲜有报道。我们报告了一例69岁男性骨盆骨折(AO/OTA型B2.1),他成功地接受了腹腔镜辅助耻骨支钢板固定,没有辅助切口。我们设计并应用了适用于腹腔镜手术的单独定制的内固定安装加长手术器械,在腹腔镜下完成整个复位和内固定安装。术后1天患者可坐起,疼痛视觉模拟评分由术前5分下降至1分。术后2周,患者可单根拐杖行走。术后4周,Majeed评分为73分,术后10周,Majeed评分上升至81分。术后12周,患者能够独立行走,无疼痛,无排便和排尿功能,Majeed评分为87分。腹腔镜手术是治疗骨盆环骨折的新策略。本病例证明全腹腔镜辅助下骨盆骨折闭合复位内固定是可行的。
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引用次数: 0
Peri-implant femoral fractures in elderly: Morbidity, mortality, treatment options and good practices. 老年人股骨假体周围骨折:发病率、死亡率、治疗选择和良好做法。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2024-12-09 DOI: 10.1016/j.cjtee.2024.07.012
Luca Bianco Prevot, Vittorio Bolcato, Stefania Fozzato, Riccardo Accetta, Michela Basile, Livio Pietro Tronconi, Giuseppe Basile

Purpose: Femur fractures are among the most common fractures treated surgically, representing a significant challenge for the orthopedic surgeon. Peri-implant femoral fractures (PIFFs) represent a rare complication of the surgical treatment. It is necessary to pay attention during osteosynthesis, evaluating not only the fracture site but the entire femoral skeletal structure, the characteristics of the fracture, the health comorbidities, and the risk of malunion and pseudarthrosis. There are few studies on the incidence, treatment, and outcomes of PIFFs near osteosynthesis. This study aimed to investigate PIFF after osteosynthesis of femoral fractures and evaluate the mortality after surgery and the morbidity associated with these types of fractures.

Methods: A retrospective cohort study was carried out at the IRCCS Galeazzi Orthopedic Institute, Milan, Italy, between January, 2017 and December, 2022. Inclusion criteria were the presence of a femur fracture around an intramedullary nail to treat a previous fracture, follow-up ≥ 12 months, and patient age ≥ 65 years. Exclusion criterion was intraoperative periprosthetic fractures. The data were expressed as frequency and percentage. Continuous variables were expressed as mean ± standard deviation or median and range.

Results: Overall, 25 patients were enrolled (88.0% female) and the mean age was 84.5 years (range of 70 - 92 years). There were 20 patients having type B PIFF and 5 having type C. In 22 patients, multiple comorbidities were found with an average Charlson comorbidity score of 5.5 and the mean time to peri-implant fracture was 38 months. After surgery, 1 patient (4.0%) presented renal failure, 1 (4.0%) needed removal surgery for their loosening, and 2 (8.0%) presented surgical site infection. Nine patients (36.0%) died within 1 year with a mortality rate of 20. 0% at 30 days, 8.0% at 3 months, and 8.0% at 12 months.

Conclusions: PIFFs in elderly patients are associated with high short-term mortality and morbidity, so careful planning for primary fracture surgery and patient awareness to ensure prolonged compliance and a healthy lifestyle are essential for prevention.

目的:股骨骨折是外科治疗中最常见的骨折之一,对骨科医生来说是一个重大的挑战。股骨假体周围骨折(PIFFs)是手术治疗中一种罕见的并发症。在植骨过程中要注意,不仅要评估骨折部位,还要评估整个股骨骨骼结构、骨折特征、健康合并症、畸形愈合和假关节的风险。关于骨融合术附近piff的发生率、治疗和结局的研究很少。本研究旨在探讨股骨骨折植骨后的PIFF,并评估其术后死亡率和与此类骨折相关的发病率。方法:回顾性队列研究于2017年1月至2022年12月在意大利米兰的IRCCS Galeazzi骨科研究所进行。纳入标准为既往骨折治疗时髓内钉周围存在股骨骨折,随访≥12个月,患者年龄≥65岁。排除标准为术中假体周围骨折。数据以频率和百分比表示。连续变量以均数±标准差或中位数和极差表示。结果:共纳入25例患者(88.0%为女性),平均年龄为84.5岁(70 - 92岁)。20例患者为B型PIFF, 5例为c型。22例患者存在多种合并症,Charlson合并症平均评分为5.5,平均种植体周围骨折时间为38个月。术后1例(4.0%)出现肾功能衰竭,1例(4.0%)因肾脏松动需要切除,2例(8.0%)出现手术部位感染。1年内死亡9例(36.0%),死亡率为20。30天0%,3个月8.0%,12个月8.0%。结论:老年患者的PIFFs与较高的短期死亡率和发病率相关,因此精心规划原发性骨折手术,患者意识确保长期依从性和健康的生活方式对预防至关重要。
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引用次数: 0
Minimally invasive reduction of irreducible, sagittally unstable peritrochanteric fractures: Novel technique and early results. 不可复位、矢状不稳定转子周围骨折的微创复位:新技术和早期结果。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2024-12-06 DOI: 10.1016/j.cjtee.2024.08.010
Ke Li, Xing Du, Zhongyao Chen, Wei Shui

Purpose: The management of irreducible, sagittally unstable peritrochanteric fractures presents a significant challenge due to the inability to achieve closed reduction using conventional techniques. This study introduces a novel minimally invasive technique leveraging the mechanical advantage principle with long, angled hemostatic clamps.

Methods: A retrospective review was performed on 16 patients who sustained sagittally unstable peritrochanteric fractures and underwent a percutaneous hemostatic clamp leverage reduction procedure.

Inclusion criteria: (1) Preoperative confirmation of fracture type as peritrochanteric fracture; (2) Intraoperative imaging confirms the presence of sagittal plane displacement at the fracture site; (3) Age > 18 years.

Exclusion criteria: (1) Open fractures, pathological fractures, and diabetes; (2) Long-term use of corticosteroids; (3) Patients with local skin or systemic conditions not suitable for surgery. Regular follow-ups at intervals of 6 - 8 weeks continued until evidence of bone consolidation was apparent in radiographic assessments. Evaluation of the alignment quality considered factors such as the re-establishment of the neck-shaft angle, the integrity of all cortical bone edges, and the rectification of any translational displacement, while the assessment of hip functionality was performed using the Harris scoring system. Statistical analysis of the relevant data was performed using SPSS 25.0 software.

Results: The average age of these 16 patients was 56.8 years (ranging from 25 to 81 years), consisting of 8 males and 8 females. According to the AO/OTA fracture classification, the cohort included 13 cases of type 31A, 2 cases of type 32A, and 1 case of type 32C. The time from hospital admission to the day of surgery ranged from 3 to 11 days, with an average of 5.1 days. Closed reduction was successfully implemented in all 10 instances, negating the necessity for transition to open reduction procedures. The mean operative duration was 105.8 min (range 80 - 180 min). Satisfactory results of the quality of reduction were determined by comparison with the normal side. The average Harris hip score was 94.1 (range 87 - 99), and the fracture healing time was 4.2 months (3 - 6 months). Implant failure and malunion were not observed.

Conclusions: This study provides an alternative, minimally invasive technique for reducing sagittally unstable, irreducible peritrochanteric fractures. This technique holds the potential to manage complex fractures with the same efficacy as is typically reserved for simple and easily reducible fractures.

目的:由于传统技术无法实现闭合复位,因此无法复位、矢状面不稳定的转子周围骨折的治疗面临重大挑战。本研究介绍一种新颖的微创技术,利用长角度止血钳的机械优势原理。方法:对16例经皮止血钳杠杆复位术治疗的矢状不稳定转子周围骨折患者进行回顾性分析。纳入标准:(1)术前确认骨折类型为转子周围骨折;(2)术中影像学证实骨折部位矢状面移位;(3)年龄:18岁。排除标准:(1)开放性骨折、病理性骨折、糖尿病患者;(2)长期使用皮质类固醇;(3)局部皮肤或全身状况不适合手术的患者。定期随访,间隔6 - 8周,直到在x线评估中有明显的骨巩固证据。对对齐质量的评估考虑了诸如颈轴角的重建、所有皮质骨边缘的完整性以及任何平移位移的矫正等因素,同时使用Harris评分系统对髋关节功能进行评估。采用SPSS 25.0软件对相关数据进行统计分析。结果:16例患者平均年龄56.8岁(25 ~ 81岁),男8例,女8例。根据AO/OTA骨折分类,该队列包括31A型13例,32A型2例,32C型1例。从入院到手术当天的时间为3 ~ 11天,平均5.1天。所有10例病例均成功实施闭合复位,无需过渡到开放式复位。平均手术时间为105.8 min (80 ~ 180 min)。通过与正常侧的对比,确定了满意的还原质量。Harris髋关节评分平均为94.1(范围87 ~ 99),骨折愈合时间4.2个月(3 ~ 6个月)。未见种植体失败和畸形愈合。结论:本研究为降低矢状面不稳定、不可复位的转子周围骨折提供了一种替代的微创技术。该技术具有治疗复杂骨折的潜力,其疗效与通常用于简单且易于复位的骨折相同。
{"title":"Minimally invasive reduction of irreducible, sagittally unstable peritrochanteric fractures: Novel technique and early results.","authors":"Ke Li, Xing Du, Zhongyao Chen, Wei Shui","doi":"10.1016/j.cjtee.2024.08.010","DOIUrl":"https://doi.org/10.1016/j.cjtee.2024.08.010","url":null,"abstract":"<p><strong>Purpose: </strong>The management of irreducible, sagittally unstable peritrochanteric fractures presents a significant challenge due to the inability to achieve closed reduction using conventional techniques. This study introduces a novel minimally invasive technique leveraging the mechanical advantage principle with long, angled hemostatic clamps.</p><p><strong>Methods: </strong>A retrospective review was performed on 16 patients who sustained sagittally unstable peritrochanteric fractures and underwent a percutaneous hemostatic clamp leverage reduction procedure.</p><p><strong>Inclusion criteria: </strong>(1) Preoperative confirmation of fracture type as peritrochanteric fracture; (2) Intraoperative imaging confirms the presence of sagittal plane displacement at the fracture site; (3) Age > 18 years.</p><p><strong>Exclusion criteria: </strong>(1) Open fractures, pathological fractures, and diabetes; (2) Long-term use of corticosteroids; (3) Patients with local skin or systemic conditions not suitable for surgery. Regular follow-ups at intervals of 6 - 8 weeks continued until evidence of bone consolidation was apparent in radiographic assessments. Evaluation of the alignment quality considered factors such as the re-establishment of the neck-shaft angle, the integrity of all cortical bone edges, and the rectification of any translational displacement, while the assessment of hip functionality was performed using the Harris scoring system. Statistical analysis of the relevant data was performed using SPSS 25.0 software.</p><p><strong>Results: </strong>The average age of these 16 patients was 56.8 years (ranging from 25 to 81 years), consisting of 8 males and 8 females. According to the AO/OTA fracture classification, the cohort included 13 cases of type 31A, 2 cases of type 32A, and 1 case of type 32C. The time from hospital admission to the day of surgery ranged from 3 to 11 days, with an average of 5.1 days. Closed reduction was successfully implemented in all 10 instances, negating the necessity for transition to open reduction procedures. The mean operative duration was 105.8 min (range 80 - 180 min). Satisfactory results of the quality of reduction were determined by comparison with the normal side. The average Harris hip score was 94.1 (range 87 - 99), and the fracture healing time was 4.2 months (3 - 6 months). Implant failure and malunion were not observed.</p><p><strong>Conclusions: </strong>This study provides an alternative, minimally invasive technique for reducing sagittally unstable, irreducible peritrochanteric fractures. This technique holds the potential to manage complex fractures with the same efficacy as is typically reserved for simple and easily reducible fractures.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FM1-Editorial board FM1-编辑部
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2024-11-20 DOI: 10.1016/S1008-1275(24)00121-4
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引用次数: 0
期刊
Chinese Journal of Traumatology
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