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The surveillance and assessment of acute injuries in different age categories in national wrestling championships 监测和评估全国摔跤锦标赛中不同年龄组别的急性损伤情况。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2024.09.001
Sema Can , Erkan Demirkan , Mustafa Arıcı , Mehmet İsmail Tosun , Halil İbrahim Cicioğlu

Purpose

The purpose of this study is to surveil the injuries in wrestling according to the different age categories and wrestling styles throughout the competition season.

Methods

The study was designed as a descriptive study. The study was conducted during the wrestling competition season in 2023 (from January 2023 to July 2023), which includes 5 different age categories: U-15, U-17, U-20, U-23, and seniors, along with the Turkey National Wrestling Championships. The data of injuries was recorded immediately after the acute injury was treated by the medical expert during the competitions and evaluated according to the parameters that were obtained. In the statistical analysis, the frequency and percentage values were presented as descriptive statistics and the Chi-square test was used.

Results

The study incorporated a total of 6214 wrestlers and a total of 7151 wrestling bouts were performed during these competitions. The analyses indicated that the rate of injury incidence was 42.65‰ in all wrestling styles. When taking account of the injured body parts in all wrestlers’ exposures, the occurrence of injuries to the head-face, neck, trunk, upper extremity, and lower extremity, rates of 17.6‰, 1.3‰, 3.6‰, 13.5‰, and 6.6‰, respectively, were observed. According to the pre-diagnosis based on freestyle, Greco-Roman, and female wrestling styles, injuries with bleeding (39.6%, 46.3%, and 14.6%, respectively) and muscle strain (37.9%, 28.7 %, and 52.6%, respectively) most often occurred.

Conclusion

The study findings indicate that most cases of injury appeared to occur in bleeding and muscle strain in all wrestling styles. We suggest that medical experts should set up their health equipment with consideration to the injuries that occur most frequently.
目的:本研究的目的是根据不同年龄组别和摔跤风格,调查整个比赛季节摔跤运动中的受伤情况:本研究为描述性研究。研究在 2023 年摔跤比赛季节(2023 年 1 月至 2023 年 7 月)进行,包括 5 个不同年龄组别:包括 5 个不同年龄组:U-15、U-17、U-20、U-23 和老年组,以及土耳其全国摔跤锦标赛。受伤数据是在比赛期间由医疗专家对急性损伤进行治疗后立即记录的,并根据获得的参数进行评估。在统计分析中,以频率和百分比值作为描述性统计,并使用卡方检验:研究共涉及 6214 名摔跤运动员,在这些比赛中共进行了 7151 次摔跤比赛。分析表明,所有摔跤项目的受伤率均为 42.65‰。考虑到所有摔跤运动员受伤的身体部位,头面部、颈部、躯干、上肢和下肢的受伤发生率分别为 17.6‰、1.3‰、3.6‰、13.5‰和 6.6‰。根据自由式摔跤、希腊罗马式摔跤和女子摔跤的前期诊断,出血(分别为 39.6%、46.3% 和 14.6%)和肌肉拉伤(分别为 37.9%、28.7% 和 52.6%)是最常发生的损伤:研究结果表明,在所有摔跤类型中,大多数损伤似乎都发生在出血和肌肉拉伤上。我们建议医疗专家在设置医疗设备时应考虑到最常发生的损伤。
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引用次数: 0
Corrigendum to “Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3” [Chinese J Traumatol 22 (2019) 161–165] 右美托咪定通过抑制NLRP3降低手术损伤诱导的海马小胶质细胞炎症反应[J].中华创伤杂志22(2019)161-165。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2024.12.001
Ji Peng, Peng Zhang, Han Zheng, Yun-Qin Ren, Hong Yan
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引用次数: 0
Complications among patients undergoing orthopedic surgery after infection with the SARS-CoV-2 Omicron strain and a preliminary nomogram for predicting patient outcomes 感染SARS-CoV-2 Omicron菌株后接受骨科手术患者的并发症及预测患者预后的初步nomogram
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.02.003
Liang Zhang , Wen-Long Gou , Ke-Yu Luo , Jun Zhu , Yi-Bo Gan , Xiang Yin , Jun-Gang Pu , Huai-Jian Jin , Xian-Qing Zhang , Wan-Fei Wu , Zi-Ming Wang , Yao-Yao Liu , Yang Li , Peng Liu

Purpose

The rate of complications among patients undergoing surgery has increased due to infection with SARS-CoV-2 and other variants of concern. However, Omicron has shown decreased pathogenicity, raising questions about the risk of postoperative complications among patients who are infected with this variant. This study aimed to investigate complications and related factors among patients with recent Omicron infection prior to undergoing orthopedic surgery.

Methods

A historical control study was conducted. Data were collected from all patients who underwent surgery during 2 distinct periods: (1) between Dec 12, 2022 and Jan 31, 2023 (COVID-19 positive group), (2) between Dec 12, 2021 and Jan 31, 2022 (COVID-19 negative control group). The patients were at least 18 years old. Patients who received conservative treatment after admission or had high-risk diseases or special circumstances (use of anticoagulants before surgery) were excluded from the study. The study outcomes were the total complication rate and related factors. Binary logistic regression analysis was used to identify related factors, and odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the impact of COVID-19 infection on complications.

Results

In the analysis, a total of 847 patients who underwent surgery were included, with 275 of these patients testing positive for COVID-19 and 572 testing negative. The COVID-19-positive group had a significantly higher rate of total complications (11.27%) than the control group (4.90%, p < 0.001). After adjusting for relevant factors, the OR was 3.08 (95% CI: 1.45–6.53). Patients who were diagnosed with COVID-19 at 3–4 weeks (OR = 0.20 (95% CI: 0.06–0.59), p = 0.005), 5–6 weeks (OR = 0.16 (95% CI: 0.04–0.59), p = 0.010), or ≥7 weeks (OR = 0.26 (95% CI: 0.06–1.02), p = 0.069) prior to surgery had a lower risk of complications than those who were diagnosed at 0–2 weeks prior to surgery. Seven factors (age, indications for surgery, time of operation, time of COVID-19 diagnosis prior to surgery, C-reactive protein levels, alanine transaminase levels, and aspartate aminotransferase levels) were found to be associated with complications; thus, these factors were used to create a nomogram.

Conclusion

Omicron continues to be a significant factor in the incidence of postoperative complications among patients undergoing orthopedic surgery. By identifying the factors associated with these complications, we can determine the optimal surgical timing, provide more accurate prognostic information, and offer appropriate consultation for orthopedic surgery patients who have been infected with Omicron.
目的:由于感染了SARS-CoV-2和其他相关变异,手术患者的并发症发生率有所增加。然而,Omicron已显示出较低的致病性,这引发了关于感染该变异的患者术后并发症风险的问题。本研究旨在探讨骨科手术前近期欧米克隆感染患者的并发症及相关因素。方法:采用历史对照研究。数据收集于两个不同时期接受手术的所有患者:(1)2022年12月12日至2023年1月31日(COVID-19阳性组),(2)2021年12月12日至2022年1月31日(COVID-19阴性对照组)。这些患者至少18岁。入院后接受保守治疗或有高危疾病或特殊情况(术前使用抗凝剂)的患者排除在研究之外。研究结果为总并发症发生率及相关因素。采用二元logistic回归分析确定相关因素,计算比值比(OR)和95%置信区间(CI)评估COVID-19感染对并发症的影响。结果:共纳入847例手术患者,其中新冠肺炎阳性275例,阴性572例。阳性组总并发症发生率(11.27%)显著高于对照组(4.90%,p < 0.001)。校正相关因素后,OR为3.08 (95% CI: 1.45-6.53)。术前3-4周(OR 0.20 (95% CI: 0.06-0.59), p = 0.005), 5-6周(OR 0.16 (0.04-0.59), p = 0.010)或≥7周(OR 0.26 (0.06-1.02), p = 0.069)诊断为COVID-19的患者发生并发症的风险低于术前0-2周诊断为COVID-19的患者。年龄、手术适应证、手术时间、术前COVID-19诊断时间、c反应蛋白水平、丙氨酸转氨酶水平、天冬氨酸转氨酶水平等7个因素与并发症相关;因此,这些因素被用来创建一个nomogram。结论:在骨科手术患者中,Omicron仍然是术后并发症发生率的重要因素。通过确定与这些并发症相关的因素,我们可以确定最佳手术时机,提供更准确的预后信息,并为感染了Omicron的骨科手术患者提供适当的咨询。
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引用次数: 0
Early prediction and warning of MODS following major trauma via identification of cytokine storm: A prospective cohort study 通过鉴定细胞因子风暴对重大创伤后MODS的早期预测和预警:一项前瞻性队列研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.05.001
Panpan Chang , Rui Li , Jiahe Wen , Guanjun Liu , Feifei Jin , Yongpei Yu , Yongzheng Li , Guang Zhang , Tianbing Wang

Purpose

Early mortality in major trauma has decreased, but MODS remains a leading cause of poor outcomes, driven by trauma-induced cytokine storms that exacerbate injuries and organ damage.

Methods

This prospective cohort study included 79 major trauma patients (ISS >15) treated in the National Center for Trauma Medicine, Peking University People's Hospital, from September 1, 2021, to July 31, 2023. Patients (1) with ISS >15 (according to AIS 2015), (2) aged 15–80 years, (3) admitted within 6 h of injury, (4) having no prior treatment before admission, were included. Exclusion criteria were (1) GCS score <9 or AIS score ≥3 for TBI, (2) confirmed infection, infectious disease, or high infection risk, (3) pregnancy, (4) severe primary diseases affecting survival, (5) recent use of immunosuppressive or cytotoxic drugs within the past 6 months, (6) psychiatric patients, (7) participation in other clinical trials within the past 30 days, (8) patients with incomplete data or missing blood samples. Admission serum inflammatory cytokines and pathophysiological data were analyzed to develop machine learning models predicting MODS within 7 days. LR, DR, RF, SVM, NB, and XGBoost were evaluated based on the area under the AUROC. The SHAP method was used to interpret results.

Results

This study enrolled 79 patients with major trauma, and the median (Q1, Q3) age was 51 (35, 59) years (52 males, 65.8%). The inflammatory cytokine data were collected for all participants. Among these patients, 35 (44.3%) developed MODS, and 44 (55.7%) did not. Additionally, 2 patients (2.5%) from the MODS group succumbed. The logistic regression model showed strong performance in predicting MODS. Ten key cytokines, IL-18, Eotaxin, MCP-4, IP-10, CXCL12, MIP-3α, MCP-1, IL-1RA, Cystatin C, and MRP8/14 were identified as critical to the trauma-induced cytokine storm and MODS development. Early elevation of these cytokines achieved high predictive accuracy, with an AUROC of 0.887 (95% CI 0.813–0.976).

Conclusion

Trauma-induced cytokine storms are strongly associated with MODS. Early identification of inflammatory cytokine changes enables better prediction and timely interventions to improve outcomes.
目的:严重创伤的早期死亡率已经下降,但MODS仍然是导致预后不良的主要原因,创伤诱导的细胞因子风暴加剧了损伤和器官损伤。方法:本前瞻性队列研究纳入了2021年9月1日至2023年7月31日在北京大学人民医院国家创伤医学中心治疗的79例重大创伤患者(ISS bbbb15)。纳入患者(1)ISS bbb15(根据AIS 2015),(2)年龄15-80岁,(3)受伤后6小时内入院,(4)入院前未接受治疗。结果:本研究纳入79例严重创伤患者,中位(Q1, Q3)年龄为51(35,59)岁(男性52例,65.8%)。收集所有参与者的炎症细胞因子数据。其中35例(44.3%)发生MODS, 44例(55.7%)未发生MODS。此外,MODS组2例(2.5%)患者死亡。logistic回归模型对MODS的预测效果较好。10个关键细胞因子IL-18、Eotaxin、MCP-4、IP-10、CXCL12、MIP-3α、MCP-1、IL-1RA、Cystatin C和MRP8/14被确定为创伤诱导的细胞因子风暴和MODS发展的关键。这些细胞因子的早期升高具有很高的预测准确性,AUROC为0.887 (95% CI 0.813-0.976)。结论:创伤性细胞因子风暴与MODS密切相关。早期识别炎症细胞因子变化可以更好地预测和及时干预,以改善预后。
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引用次数: 0
The positioning of cephalon medullary nailing correlated with hidden blood loss during the perioperative period in patients with intertrochanteric fractures: A retrospective study 股骨粗隆间骨折围手术期头髓内钉定位与隐性出血量的相关性:回顾性研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.03.002
Yao Chen, Shaobo Zhang, Zhiqi Liu, Jiashan Li

Purpose

Hidden blood loss (HBL) during the perioperative period significantly impacts postoperative recovery and complications, yet it is frequently disregarded. This study aimed to investigate the effects of tip-apex distance (TAD) and calcar-referenced tip-apex distance (calTAD) on HBL in the treatment of intertrochanteric fractures utilizing proximal femoral nail antirotation (PFNA). The study also seeks to evaluate the possible decrease in HBL subsequent to PFNA treatment by optimizing nail positioning.

Method

A historical cohort study was conducted from January 2020 to December 2022. Patients diagnosed with unilateral acute closed femoral intertrochanteric fracture and who underwent PFNA internal fixation surgery met the inclusion criteria, and were grouped according to the value of calTAD and TAD. The participants were divided into low TAD group (TAD<20 mm) and high TAD group (TAD≥20 mm); low calTAD group (calTAD<7.625 mm) and high calTAD group (calTAD≥7.625 mm), respectively. The primary outcome measures were intraoperative blood loss (including HBL, overt blood loss, and total blood loss). Continuous data were analyzed using an independent sample t-test or Mann-Whitney U test, and categorical data were analyzed using the Pearson Chi-square test. Univariate analysis was used to evaluate the association between various indicators and perioperative HBL. A stepwise multiple linear regression analysis model was used to determine the independent factors affecting perioperative HBL. A p value less than 0.05 was considered statistically significant.

Results

A total of 131 patients were initially included, of which 80 were assigned to the calTAD group (with 61 in the high calTAD group and 19 in the low calTAD group), and 80 were assigned to the TAD group (with 34 in the high TAD group and 46 in the low TAD group). The average HBL for the low TAD group was 772.85 mL, whereas for the high TAD group it was 919.68 mL (p>0.05). The average HBL for the low calTAD group was 611.42 mL, whereas for the high calTAD group it was 904.97 mL (p<0.05). Subsequent analysis revealed that the patient's height, preoperative hemoglobin levels, changes in hemoglobin and hematocrit levels from pre- to post-surgery, and calTAD are independent risk factors influencing HBL.

Conclusion

In summary, our investigation revealed a significant correlation between the positioning of nails in PFNA and HBL during the perioperative period. By optimizing the placement of the cephalic nail, specifically by ensuring a calTAD of less than 7.625 mm, a significant decrease in HBL can be attained. Additionally, we identified that height, preoperative hemoglobin, differences in preoperative and postoperative hemoglobin and hematocrit, and the positioning of the cephalic nail were independent risk factors for HBL.
目的:围手术期隐性失血量(HBL)对术后恢复及并发症有显著影响,但常被忽视。本研究旨在探讨利用股骨近端钉防旋(PFNA)治疗股骨粗隆间骨折时,尖端距离(TAD)和钙参考尖端距离(calTAD)对HBL的影响。该研究还试图通过优化钉位来评估PFNA治疗后HBL的可能降低。方法:于2020年1月至2022年12月进行历史队列研究。诊断为单侧急性闭合性股骨粗隆间骨折并行PFNA内固定手术的患者符合纳入标准,根据calTAD和TAD值进行分组。结果:最初共纳入131例患者,其中80例患者被分配到calTAD组(高calTAD组61例,低calTAD组19例),80例患者被分配到TAD组(高TAD组34例,低TAD组46例)。低TAD组平均HBL为772.85 mL,高TAD组平均HBL为919.68 mL (p < 0.05)。低calTAD组的平均HBL为611.42 mL,而高calTAD组的平均HBL为904.97 mL。结论:综上所述,我们的研究显示围手术期钉在PFNA中的定位与HBL有显著的相关性。通过优化头侧钉的位置,特别是确保尺径小于7.625 mm,可以显著降低HBL。此外,我们发现身高、术前血红蛋白、术前和术后血红蛋白和红细胞压积的差异以及头甲的位置是HBL的独立危险因素。
{"title":"The positioning of cephalon medullary nailing correlated with hidden blood loss during the perioperative period in patients with intertrochanteric fractures: A retrospective study","authors":"Yao Chen,&nbsp;Shaobo Zhang,&nbsp;Zhiqi Liu,&nbsp;Jiashan Li","doi":"10.1016/j.cjtee.2025.03.002","DOIUrl":"10.1016/j.cjtee.2025.03.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Hidden blood loss (HBL) during the perioperative period significantly impacts postoperative recovery and complications, yet it is frequently disregarded. This study aimed to investigate the effects of tip-apex distance (TAD) and calcar-referenced tip-apex distance (calTAD) on HBL in the treatment of intertrochanteric fractures utilizing proximal femoral nail antirotation (PFNA). The study also seeks to evaluate the possible decrease in HBL subsequent to PFNA treatment by optimizing nail positioning.</div></div><div><h3>Method</h3><div>A historical cohort study was conducted from January 2020 to December 2022. Patients diagnosed with unilateral acute closed femoral intertrochanteric fracture and who underwent PFNA internal fixation surgery met the inclusion criteria, and were grouped according to the value of calTAD and TAD. The participants were divided into low TAD group (TAD&lt;20 mm) and high TAD group (TAD≥20 mm); low calTAD group (calTAD&lt;7.625 mm) and high calTAD group (calTAD≥7.625 mm), respectively. The primary outcome measures were intraoperative blood loss (including HBL, overt blood loss, and total blood loss). Continuous data were analyzed using an independent sample <em>t</em>-test or Mann-Whitney <em>U</em> test, and categorical data were analyzed using the Pearson Chi-square test. Univariate analysis was used to evaluate the association between various indicators and perioperative HBL. A stepwise multiple linear regression analysis model was used to determine the independent factors affecting perioperative HBL. A <em>p</em> value less than 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>A total of 131 patients were initially included, of which 80 were assigned to the calTAD group (with 61 in the high calTAD group and 19 in the low calTAD group), and 80 were assigned to the TAD group (with 34 in the high TAD group and 46 in the low TAD group). The average HBL for the low TAD group was 772.85 mL, whereas for the high TAD group it was 919.68 mL (<em>p</em>&gt;0.05). The average HBL for the low calTAD group was 611.42 mL, whereas for the high calTAD group it was 904.97 mL (<em>p</em>&lt;0.05). Subsequent analysis revealed that the patient's height, preoperative hemoglobin levels, changes in hemoglobin and hematocrit levels from pre- to post-surgery, and calTAD are independent risk factors influencing HBL.</div></div><div><h3>Conclusion</h3><div>In summary, our investigation revealed a significant correlation between the positioning of nails in PFNA and HBL during the perioperative period. By optimizing the placement of the cephalic nail, specifically by ensuring a calTAD of less than 7.625 mm, a significant decrease in HBL can be attained. Additionally, we identified that height, preoperative hemoglobin, differences in preoperative and postoperative hemoglobin and hematocrit, and the positioning of the cephalic nail were independent risk factors for HBL.</div></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 6","pages":"Pages 503-508"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on a yorkshire model of brain injury after traumatic blood loss 亚低温机械灌注联合膜肺氧合对创伤性失血脑损伤约克郡模型的保护作用。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2024.10.003
Xiang-Yu Song , Yang-Hui Dong , Zhi-Bo Jia , Lei-Jia Chen , Meng-Yi Cui , Yan-Jun Guan , Bo-Yao Yang , Si-Ce Wang , Sheng-Feng Chen , Peng-Kai Li , Heng Chen , Hao-Chen Zuo , Zhan-Cheng Yang , Wen-Jing Xu , Ya-Qun Zhao , Jiang Peng
<div><h3>Purpose</h3><div>To investigate the protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on ischemic hypoxic injury of yorkshire brain tissue caused by traumatic blood loss.</div></div><div><h3>Methods</h3><div>This article performed a random controlled trial. Brain tissue of 7 yorkshire was selected and divided into the sub-low temperature anterograde machine perfusion group (<em>n</em> = 4) and the blank control group (<em>n</em> = 3) using the random number table method. A yorkshire model of brain tissue injury induced by traumatic blood loss was established. Firstly, the perfusion temperature and blood oxygen saturation were monitored in real-time during the perfusion process. The number of red blood cells, hemoglobin content, NA<sup>+</sup>, K<sup>+</sup>, and Ca<sup>2+</sup> ions concentrations and pH of the perfusate were detected. Following perfusion, we specifically examined the parietal lobe to assess its water content. The prefrontal cortex and hippocampus were then dissected for histological evaluation, allowing us to investigate potential regional differences in tissue injury. The blank control group was sampled directly before perfusion. All statistical analyses and graphs were performed using GraphPad Prism 8.0 Student <em>t</em>-test. All tests were two-sided, and <em>p</em> value of less than 0.05 was considered to indicate statistical significance.</div></div><div><h3>Results</h3><div>The contents of red blood cells and hemoglobin during perfusion were maintained at normal levels but more red blood cells were destroyed 3 h after the perfusion. The blood oxygen saturation of the perfusion group was maintained at 95% − 98%. NA<sup>+</sup> and K<sup>+</sup> concentrations were normal most of the time during perfusion but increased significantly at about 4 h. The Ca<sup>2+</sup> concentration remained within the normal range at each period. Glucose levels were slightly higher than the baseline level. The pH of the perfusion solution was slightly lower at the beginning of perfusion, and then gradually increased to the normal level. The water content of brain tissue in the sub-low and docile perfusion group was 78.95% ± 0.39%, which was significantly higher than that in the control group (75.27% ± 0.55%, <em>t</em> = 10.49, <em>p</em> < 0.001), and the difference was statistically significant. Compared with the blank control group, the structure and morphology of pyramidal neurons in the prefrontal cortex and CA1 region of the hippocampal gyrus were similar, and their integrity was better. The structural integrity of granulosa neurons was destroyed and cell edema increased in the perfusion group compared with the blank control group. Immunofluorescence staining for glail fibrillary acidic protein and Iba1, markers of glial cells, revealed well-preserved cell structures in the perfusion group. While there were indications of abnormal cellular activity, the analysis showed no sign
目的:探讨亚低温机械灌注联合膜肺氧合对外伤性失血所致约克郡脑组织缺血性缺氧损伤的保护作用。方法:采用随机对照试验。选取7只大约克羊脑组织,采用随机数字表法分为亚低温顺行机灌注组(n = 4)和空白对照组(n = 3)。建立外伤性失血致脑组织损伤约克郡模型。首先,实时监测灌注过程中的灌注温度和血氧饱和度。检测灌注液红细胞数量、血红蛋白含量、NA+、K+、Ca2+离子浓度及pH值。灌注后,我们专门检查顶叶以评估其含水量。然后解剖前额叶皮层和海马体进行组织学评估,使我们能够研究组织损伤的潜在区域差异。空白对照组在灌注前直接取样。所有统计分析和图表均采用GraphPad Prism 8.0学生t检验。所有检验均为双侧检验,p值小于0.05为有统计学意义。结果:灌注时红细胞和血红蛋白含量维持在正常水平,但灌注后3 h红细胞破坏较多。灌注组血氧饱和度维持在95% ~ 98%。NA+和K+浓度在灌注期间大部分时间正常,但在4 h左右显著升高。Ca2+浓度在各时期保持在正常范围内。血糖水平略高于基线水平。灌注液的pH值在灌注开始时略低,然后逐渐升高至正常水平。亚低温和温和灌注组脑组织含水量为78.95%±0.39%,显著高于对照组(75.27%±0.55%),t = 10.49, p结论:亚低温机灌注可通过持续供氧,维持离子稳态,降低组织代谢水平,改善外伤性失血引起的约克郡脑组织缺血缺氧损伤,延缓约克郡脑组织坏死和凋亡。
{"title":"Protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on a yorkshire model of brain injury after traumatic blood loss","authors":"Xiang-Yu Song ,&nbsp;Yang-Hui Dong ,&nbsp;Zhi-Bo Jia ,&nbsp;Lei-Jia Chen ,&nbsp;Meng-Yi Cui ,&nbsp;Yan-Jun Guan ,&nbsp;Bo-Yao Yang ,&nbsp;Si-Ce Wang ,&nbsp;Sheng-Feng Chen ,&nbsp;Peng-Kai Li ,&nbsp;Heng Chen ,&nbsp;Hao-Chen Zuo ,&nbsp;Zhan-Cheng Yang ,&nbsp;Wen-Jing Xu ,&nbsp;Ya-Qun Zhao ,&nbsp;Jiang Peng","doi":"10.1016/j.cjtee.2024.10.003","DOIUrl":"10.1016/j.cjtee.2024.10.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;To investigate the protective effect of sub-hypothermic mechanical perfusion combined with membrane lung oxygenation on ischemic hypoxic injury of yorkshire brain tissue caused by traumatic blood loss.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This article performed a random controlled trial. Brain tissue of 7 yorkshire was selected and divided into the sub-low temperature anterograde machine perfusion group (&lt;em&gt;n&lt;/em&gt; = 4) and the blank control group (&lt;em&gt;n&lt;/em&gt; = 3) using the random number table method. A yorkshire model of brain tissue injury induced by traumatic blood loss was established. Firstly, the perfusion temperature and blood oxygen saturation were monitored in real-time during the perfusion process. The number of red blood cells, hemoglobin content, NA&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt;, and Ca&lt;sup&gt;2+&lt;/sup&gt; ions concentrations and pH of the perfusate were detected. Following perfusion, we specifically examined the parietal lobe to assess its water content. The prefrontal cortex and hippocampus were then dissected for histological evaluation, allowing us to investigate potential regional differences in tissue injury. The blank control group was sampled directly before perfusion. All statistical analyses and graphs were performed using GraphPad Prism 8.0 Student &lt;em&gt;t&lt;/em&gt;-test. All tests were two-sided, and &lt;em&gt;p&lt;/em&gt; value of less than 0.05 was considered to indicate statistical significance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The contents of red blood cells and hemoglobin during perfusion were maintained at normal levels but more red blood cells were destroyed 3 h after the perfusion. The blood oxygen saturation of the perfusion group was maintained at 95% − 98%. NA&lt;sup&gt;+&lt;/sup&gt; and K&lt;sup&gt;+&lt;/sup&gt; concentrations were normal most of the time during perfusion but increased significantly at about 4 h. The Ca&lt;sup&gt;2+&lt;/sup&gt; concentration remained within the normal range at each period. Glucose levels were slightly higher than the baseline level. The pH of the perfusion solution was slightly lower at the beginning of perfusion, and then gradually increased to the normal level. The water content of brain tissue in the sub-low and docile perfusion group was 78.95% ± 0.39%, which was significantly higher than that in the control group (75.27% ± 0.55%, &lt;em&gt;t&lt;/em&gt; = 10.49, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), and the difference was statistically significant. Compared with the blank control group, the structure and morphology of pyramidal neurons in the prefrontal cortex and CA1 region of the hippocampal gyrus were similar, and their integrity was better. The structural integrity of granulosa neurons was destroyed and cell edema increased in the perfusion group compared with the blank control group. Immunofluorescence staining for glail fibrillary acidic protein and Iba1, markers of glial cells, revealed well-preserved cell structures in the perfusion group. While there were indications of abnormal cellular activity, the analysis showed no sign","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 6","pages":"Pages 469-476"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of CT scoring systems and a simplified prediction model in pediatric moderate-to-severe traumatic brain injury. CT评分系统及简化预测模型在小儿中重度颅脑损伤中的预后价值。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-21 DOI: 10.1016/j.cjtee.2025.09.002
Yangyang Diao, Ping Liang

Purpose: To evaluate the prognostic performance of 4 CT scoring systems in pediatric patients with moderate-to-severe traumatic brain injury (TBI) and develop a simplified, interpretable predictive model based on machine learning.

Methods: This retrospective study included 103 pediatric patients with moderate-to-severe TBI admitted to a tertiary children's hospital in Southwest China from September 2020 to December 2023. CT images were assessed using the Marshall score, Rotterdam score, Helsinki score, and Stockholm score. Clinical outcomes were defined by the Glasgow outcome scale (GOS) and categorized as favorable results (GOS 4-5) or unfavorable results (GOS 1-3). The dataset was divided into a training set (n=83) and a test set (n=20). Class imbalance was corrected using the random over-sampling examples method. Eight classification models were compared through 5-fold cross-validation. The Naive Bayes model showed the best performance and was simplified to include 5 key predictors. An interactive online application was developed to provide individualized prognostic estimation and visualization.

Results: The Helsinki score demonstrated the highest predictive accuracy among the 4 CT scores (area under the curve (AUC)=0.906), followed by the Stockholm score (AUC=0.897), Rotterdam score (AUC=0.837), and Marshall score (AUC=0.764). The simplified Naive Bayes model achieved an AUC of 0.930, with 100% sensitivity and 65.9% specificity in the test set. The model enables real-time outcome prediction and visual interpretation of contributing factors.

Conclusions: The simplified Naive Bayes model outperforms traditional CT scoring systems in predicting outcomes of pediatric moderate-to-severe TBI. Its easy use, interpretability, and web-based implementation support its potential for clinical application. Further prospective and multicenter studies are needed to validate these findings.

目的:评价4种CT评分系统对中重度颅脑损伤(TBI)患儿预后的预测效果,建立一种基于机器学习的简化、可解释的预测模型。方法:本回顾性研究纳入了2020年9月至2023年12月在西南地区某三级儿童医院收治的103例中重度脑外伤患儿。采用Marshall评分、鹿特丹评分、赫尔辛基评分和斯德哥尔摩评分对CT图像进行评估。临床结果由格拉斯哥结局量表(GOS)定义,分为有利结果(GOS 4-5)和不利结果(GOS 1-3)。数据集分为训练集(n=83)和测试集(n=20)。采用随机过采样方法修正了类不平衡。通过5倍交叉验证对8种分类模型进行比较。朴素贝叶斯模型表现最好,并被简化为包括5个关键预测因子。开发了一个交互式在线应用程序,以提供个性化的预后估计和可视化。结果:4个CT评分中,赫尔辛基评分的预测准确率最高(曲线下面积(AUC)=0.906),其次是斯德哥尔摩评分(AUC=0.897)、鹿特丹评分(AUC=0.837)和马歇尔评分(AUC=0.764)。简化朴素贝叶斯模型的AUC为0.930,灵敏度为100%,特异度为65.9%。该模型能够实现实时结果预测和促成因素的可视化解释。结论:简化的朴素贝叶斯模型在预测儿童中重度脑外伤预后方面优于传统的CT评分系统。其易于使用,可解释性和基于web的实施支持其临床应用的潜力。需要进一步的前瞻性和多中心研究来验证这些发现。
{"title":"Prognostic value of CT scoring systems and a simplified prediction model in pediatric moderate-to-severe traumatic brain injury.","authors":"Yangyang Diao, Ping Liang","doi":"10.1016/j.cjtee.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.09.002","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the prognostic performance of 4 CT scoring systems in pediatric patients with moderate-to-severe traumatic brain injury (TBI) and develop a simplified, interpretable predictive model based on machine learning.</p><p><strong>Methods: </strong>This retrospective study included 103 pediatric patients with moderate-to-severe TBI admitted to a tertiary children's hospital in Southwest China from September 2020 to December 2023. CT images were assessed using the Marshall score, Rotterdam score, Helsinki score, and Stockholm score. Clinical outcomes were defined by the Glasgow outcome scale (GOS) and categorized as favorable results (GOS 4-5) or unfavorable results (GOS 1-3). The dataset was divided into a training set (n=83) and a test set (n=20). Class imbalance was corrected using the random over-sampling examples method. Eight classification models were compared through 5-fold cross-validation. The Naive Bayes model showed the best performance and was simplified to include 5 key predictors. An interactive online application was developed to provide individualized prognostic estimation and visualization.</p><p><strong>Results: </strong>The Helsinki score demonstrated the highest predictive accuracy among the 4 CT scores (area under the curve (AUC)=0.906), followed by the Stockholm score (AUC=0.897), Rotterdam score (AUC=0.837), and Marshall score (AUC=0.764). The simplified Naive Bayes model achieved an AUC of 0.930, with 100% sensitivity and 65.9% specificity in the test set. The model enables real-time outcome prediction and visual interpretation of contributing factors.</p><p><strong>Conclusions: </strong>The simplified Naive Bayes model outperforms traditional CT scoring systems in predicting outcomes of pediatric moderate-to-severe TBI. Its easy use, interpretability, and web-based implementation support its potential for clinical application. Further prospective and multicenter studies are needed to validate these findings.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scrotal reconstruction using anterolateral thigh flap in a pediatric patient: A case report. 应用股前外侧皮瓣重建小儿阴囊1例。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-09-26 DOI: 10.1016/j.cjtee.2025.05.002
Shi Gao, Haiqiong Chen, Guoqiang Zhao

Avulsion injury of genitalia is rare, particularly in pediatric patients. The reconstruction of necrotic scrotal tissue presents a significant challenge. This case report describes a pediatric patient who experienced complete avulsion of the left inguinal, scrotal, and penile regions, accompanied by multiple pelvic fractures, and the scrotal tissue subsequently became necrotic. We performed scrotal reconstruction using a pedicled anterolateral thigh flap and fixed both testes. Postoperatively, the scrotum had a satisfactory appearance, with no significant reduction in testicular size compared to age-matched peers, indicating a successful repair.

生殖器撕脱伤是罕见的,特别是在儿童患者。阴囊坏死组织的重建是一个重大的挑战。本病例报告描述了一名儿童患者,他经历了左侧腹股沟、阴囊和阴茎区域的完全撕脱,并伴有多处骨盆骨折,阴囊组织随后坏死。我们使用带蒂的大腿前外侧皮瓣进行阴囊重建,并固定两个睾丸。术后,阴囊外观令人满意,与同龄患者相比,睾丸大小没有明显减少,表明修复成功。
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引用次数: 0
Prehospital care: Lessons learned from 311 mortalities at level I trauma center. 院前护理:从一级创伤中心311例死亡中吸取的教训。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-09-25 DOI: 10.1016/j.cjtee.2025.02.011
Parvez Mohi Ud Din Dar, Supreet Kaur, Anand Kumar Katiyar, Pratyusha Priyadarshani, Subodh Kumar, Amit Gupta, Sushma Sagar

Purpose: Trauma, a leading cause of disability and death globally, underscores the critical importance of timely medical intervention, particularly within the "golden hour" following trauma. Yet, in low-middle-income countries, the absence or fledgling state of emergency medical systems (EMS) exacerbates mortality rates. This study aims to retrospectively analyze mortalities at a level 1 trauma center in India, comparing patients who received prehospital care with those who did not.

Methods: Conducted at a level 1 trauma center in India from April 2019 to April 2020, this retrospective observational study included trauma patients who died during hospitalization. Exclusions comprised (1) patients deceased upon arrival, (2) patients receiving cardiopulmonary resuscitation, and (3) non-trauma deaths. Demographics, clinical profiles, causes of death, and transportation methods were scrutinized. Data encompassed patient transport details, clinical assessments, interventions, length of stay, and causes of death. Statistical analysis was performed using SPSS 14, with statistical significance set at p < 0.05.

Results: Among 55,277 trauma patients, 311 mortalities were recorded. Most were male (n=267, 83.9%), aged 21-40 years (n=133, 42.8%), with blunt trauma being the predominant cause (97.4%). The majority of patients had road traffic injuries (n=180, 57.9%) and falls (n=95, 30.5%). Threatened airway (n=144, 46.3%), tachycardia (n=159, 51.2%), and hypotension (n=74, 23.8%) were common on patients' arrival. Traumatic brain injuries (70.4%) prevailed. Private vehicles transported 46.6% of patients, while only 7.0% arrived within the golden hour. Although patients who received prehospital care experienced delayed hospital arrival, they exhibited higher oxygen saturation and systolic blood pressure.

Conclusion: Augmentation of prehospital care and EMS infrastructure in low-resource settings is crucial to mitigating trauma mortality. Although prehospital care delayed hospital arrival, it positively impacted physiological parameters and potentially improved patient outcomes. This study underscores the imperative of timely interventions and comprehensive EMS development to address the global trauma burden effectively.

目的:创伤是全球造成残疾和死亡的一个主要原因,因此强调了及时进行医疗干预的极端重要性,特别是在创伤后的“黄金一小时”内。然而,在中低收入国家,紧急医疗系统的缺失或新兴状态加剧了死亡率。本研究旨在回顾性分析印度一级创伤中心的死亡率,比较接受院前护理的患者和未接受院前护理的患者。方法:本回顾性观察研究于2019年4月至2020年4月在印度一家一级创伤中心进行,纳入住院期间死亡的创伤患者。排除包括(1)到达时死亡的患者,(2)接受心肺复苏的患者,以及(3)非创伤性死亡。对人口统计、临床概况、死亡原因和交通方式进行了仔细研究。数据包括病人转运细节、临床评估、干预措施、住院时间和死亡原因。采用SPSS 14进行统计学分析,差异有统计学意义,p < 0.05。结果:55,277例创伤患者中死亡311例。多数为男性(n=267, 83.9%),年龄21 ~ 40岁(n=133, 42.8%),以钝性创伤为主(97.4%)。以道路交通伤(180例,57.9%)和跌倒(95例,30.5%)为主。患者入院时常见气道威胁(n=144, 46.3%)、心动过速(n=159, 51.2%)、低血压(n=74, 23.8%)。颅脑外伤占70.4%。私家车运送了46.6%的患者,只有7.0%的患者在黄金时间内到达。虽然接受院前护理的患者延迟到达医院,但他们表现出更高的血氧饱和度和收缩压。结论:在资源匮乏的地区,加强院前护理和急救基础设施对降低创伤死亡率至关重要。虽然院前护理延迟了住院时间,但它对生理参数有积极影响,并可能改善患者的预后。这项研究强调了及时干预和综合EMS发展的必要性,以有效地解决全球创伤负担。
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引用次数: 0
A nomogram for the prediction of traumatic intracranial abnormalities in the elderly: Development and validation. 预测老年人外伤性颅内异常的nomogram: Development and validation。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-09-25 DOI: 10.1016/j.cjtee.2025.03.003
Apisorn Jongjit, Thara Tunthanathip

Purpose: Traumatic brain injury is a major public health issue and a leading cause of death and disability among the elderly. As a result, traumatic intracerebral abnormalities (tICA) are now frequently diagnosed using cranial computed tomography (cCT), which has led to an overuse of this investigation. The present study aimed to develop and validate the nomogram for predicting tICA in the elderly.

Methods: This was a retrospective cohort study. The study population consisted of patients who met the following inclusion criteria: (1) aged ≥60 years, as defined by the World Health Organization; (2) admitted to a tertiary referral hospital between January 2015 and December 2022; and (3) underwent cCT scanning upon admission. Patients were excluded if (1) patients' images were unavailable or (2) patients died in the emergency department before hospitalization. The total data was divided into the development cohort (2015-2019, n=2052) to develop the nomogram and the validation cohort (2020-2022, n=310) to test the predictability as temporal validation. Binary logistic regression was used in the construction of the nomogram.

Results: There were 2362 patients in the entire cohort. Positive CT scan rates among the elderly amount to 21.3%. Multivariable analysis identified the following factors significantly associated with traumatic intracranial hematoma in the elderly: use of aspirin (odds ratio (OR)=4.49, 95% confidence interval (CI) 3.08-6.54), warfarin usage (OR=6.88, 95% CI 2.99-15.8), traffic accidents (OR=1.98, 95% CI 1.46-2.68), Glasgow coma scale 9-12 (OR=3.24, 95% CI 1.66-6.35), amnesia (OR=1.65, 95% CI 1.17-2.33), nausea or vomiting (OR=12.5, 95% CI 5.56-28.07), seizure (OR=11.42, 95% CI 3.33-39.22), motor weakness (OR=65.45, 95% CI 18.68-229.29), and bleeding per nose or ear (OR=24.81, 95% CI 10.57-14.58). The predictability of the nomogram demonstrated sensitivity, specificity, and an area under the receiver operating characteristic curve of 0.833, 0.788, and 0.889, respectively.

Conclusion: According to the temporal validation, the nomogram had an outstanding performance for tICA prediction in the elderly. In the future, the prediction tool will assist clinicians in making judgments and balancing the rate of cCT in clinical practice.

目的:创伤性脑损伤是一个重大的公共卫生问题,也是老年人死亡和残疾的主要原因。因此,创伤性脑内异常(tICA)现在经常使用颅计算机断层扫描(cCT)进行诊断,这导致了这种调查的过度使用。本研究旨在开发和验证预测老年人tICA的nomogram。方法:回顾性队列研究。研究人群包括符合以下纳入标准的患者:(1)年龄≥60岁,按照世界卫生组织的定义;(2) 2015年1月至2022年12月在三级转诊医院住院;(3)入院时行ct扫描。如果(1)无法获得患者的图像或(2)患者在住院前在急诊科死亡,则排除患者。将总数据分为发展队列(2015-2019年,n=2052)和验证队列(2020-2022年,n=310),以测试可预测性作为时间验证。二值逻辑回归被用于构造模态图。结果:整个队列共有2362例患者。老年人CT扫描阳性率为21.3%。多变量分析发现以下因素与老年人外伤性颅内血肿显著相关:阿司匹林的使用(优势比(OR)=4.49, 95%可信区间(CI) 3.08-6.54),华法林的使用(OR=6.88, 95% CI 2.99-15.8),交通事故(OR=1.98, 95% CI 1.46-2.68),格拉斯哥昏迷量表9-12 (OR=3.24, 95% CI 1.66-6.35),失忆(OR=1.65, 95% CI 1.17-2.33),恶心或呕吐(OR=12.5, 95% CI 5.56-28.07),癫痫发作(OR=11.42, 95% CI 3.33-39.22),运动无力(OR=65.45, 95% CI 18.68-229.29),鼻部或耳部出血(OR=24.81, 95% CI 10.57-14.58)。nomogram的灵敏度、特异度和受试者工作特征曲线下的面积分别为0.833、0.788和0.889。结论:经时间验证,nomogram对老年人tICA有较好的预测效果。未来,该预测工具将辅助临床医生在临床实践中对cCT率进行判断和平衡。
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引用次数: 0
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Chinese Journal of Traumatology
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