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Analysis of outcomes from a Level 1 trauma care hospital before and after movement to an integrated trauma care center. 一级创伤护理医院转到综合创伤护理中心前后的结果分析
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-12-01 DOI: 10.1016/j.cjtee.2025.04.005
Haarini Sundar, Carlton Rowlands, Vijayan Purushothaman, Vignesh Kumar, Srujan Lam Sharma, Shona Rachel Mathuram, Sukria Nayak, Joses Dany James

Purpose: Quality improvement in trauma care often focuses on clinical protocols and systems, with limited emphasis on trauma-specific infrastructure. This study evaluated the impact of trauma-specific infrastructural improvements on patient outcomes in a newly established quaternary care trauma center.

Methods: Data from a prospectively maintained trauma registry were retrospectively analyzed. Patients treated over 8 months at the old center (OC) were compared to those treated during an equivalent period at the new center (NC), which included trauma-specific infrastructure such as a dedicated trauma bay, CT scanner, operating rooms, intensive care unit, and ward. Outcome indicators included time to CT, emergency department (ED) disposition time, hospital stay, 24-h survival, and overall mortality. Regression analyses adjusted for clinical confounders were performed.

Results: A total of 3542 patients (OC: 1627, NC: 1915) were analyzed. The median time to CT (incident rate ratios (IRR): 0.615, 95% confidence intervals (CI): 0.494-0.767) and ED disposition time (IRR: 0.766, 95% CI: 0.641-0.914) were significantly shorter in NC, particularly for priority 1 patients. However, hospital stay was longer in the new center (IRR 1.395, 95% CI: 1.224-1.590). There was no significant difference in 24-h survival (odds ratio: 0.330, 95% CI: 0.092-1.180) or overall mortality (odds ratio: 0.328, 95% CI: 0.084-1.275.

Conclusion: Trauma-specific infrastructure improves key operational metrics like time to CT and ED disposition without significant survival benefits. These findings suggest that infrastructure, while beneficial, should complement robust clinical systems and protocols for improved trauma care quality.

目的:创伤护理质量的提高通常集中在临床方案和系统上,而对创伤特异性基础设施的重视有限。本研究评估了创伤特异性基础设施改善对新建立的创伤四级护理中心患者预后的影响。方法:回顾性分析前瞻性维护的创伤登记处的数据。在老中心(OC)治疗8个月以上的患者与在新中心(NC)治疗8个月以上的患者进行比较,新中心包括创伤专用基础设施,如专用创伤室、CT扫描仪、手术室、重症监护病房和病房。结果指标包括到CT的时间、急诊处理时间、住院时间、24小时生存率和总死亡率。对临床混杂因素进行校正后的回归分析。结果:共分析3542例患者(OC: 1627例,NC: 1915例)。NC患者到CT的中位时间(发生率比(IRR): 0.615, 95%可信区间(CI): 0.494-0.767)和ED处置时间(IRR: 0.766, 95% CI: 0.641-0.914)显著缩短,尤其是优先级1的患者。然而,新中心的住院时间更长(IRR 1.395, 95% CI: 1.224-1.590)。24小时生存率(优势比:0.330,95% CI: 0.092-1.180)和总死亡率(优势比:0.328,95% CI: 0.084-1.275)无显著差异。结论:创伤特异性基础设施改善了关键的操作指标,如CT时间和ED处置,但没有显着的生存效益。这些发现表明,基础设施虽然有益,但应补充健全的临床系统和方案,以提高创伤护理质量。
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引用次数: 0
Clinical experience in the management of penetrating stab wounds to the neck: A retrospective analysis of 5 cases. 颈部穿透性刺伤5例临床分析。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-05 DOI: 10.1016/j.cjtee.2025.02.012
Ming-Chao Ding, Shuang Qu, Jing-Fu Wang, Jin Shi, Jia-Wu Liang, Xin-Yu Wang, Guo-Liang Zhang, Jin-Long Zhao, Lei Tian, Ge Ma

Purpose: Penetrating neck trauma can frequently be life-threatening, including those that appear minor. Consequently, thorough examination and quick operative treatment have been the standard measure. In addition, modern precision medicine has shifted the procedure towards more selective non-operative management, whereas advanced imaging like computed tomography angiography plays a key role. The diagnostic and therapeutic protocol remains to be adapted and optimized. The purpose of this study was to present our experience, outcomes, and management strategy, and contribute to establishing an evidence-based algorithm for stab wounds to the neck area.

Methods: This was a retrospective, observational cohort study conducted at 3 hospitals involving 5 patients with stab wounds to the neck. Preoperative interventions included airway and circulation restoration. Ancillary investigations, including imaging and electronic laryngoscopy, were used to assess potential vascular, nerve, and cervical vertebra injury. Surgeries included exploration, debridement, and closure under general anesthesia, with blood transfusion when necessary. Patients were followed up for recovery status and provided postoperative management.

Results: Among the 5 patients aged 21-64 years, 4 were males and 1 was female. All wounds were located on the lateral aspect of the neck. Four patients had pharyngocutaneous fistulas with hematemesis/hemoptysis, and 3 of them experienced hemorrhagic shock. One patient had nerve damage, and 1 patient had an airway compressed. All patients received surgeries that were successful. Patients were followed up for more than 6 months, and examinations revealed good wound healing, partial recovery of facial nerve function, and no other residual functional impairments in any of the 5 patients.

Conclusion: Adequate preoperative preparation and assessment, timely and effective exploratory surgery, efficient multidisciplinary cooperation, and comprehensive postoperative management can maximize the chances of life-saving and functional recovery for penetrating stab wounds in the neck area.

目的:穿透性颈部创伤通常会危及生命,包括那些看似轻微的创伤。因此,彻底检查和快速手术治疗已成为标准措施。此外,现代精密医学已将治疗过程转向更具选择性的非手术治疗,而计算机断层血管造影等先进成像技术起着关键作用。诊断和治疗方案仍有待调整和优化。本研究的目的是介绍我们的经验、结果和管理策略,并为建立颈部刺伤的循证算法做出贡献。方法:回顾性、观察性队列研究在3家医院进行,涉及5例颈部刺伤患者。术前干预包括气道和循环恢复。辅助检查,包括影像学和电子喉镜检查,用于评估潜在的血管、神经和颈椎损伤。手术包括探查、清创和全身麻醉下的缝合,必要时输血。随访患者的恢复情况及术后处理。结果:5例患者年龄21 ~ 64岁,男性4例,女性1例。所有伤口都在颈部外侧。4例患者出现咽瘘伴呕血/咯血,3例出现失血性休克。1例有神经损伤,1例有气道受压。所有患者都接受了成功的手术。随访6个月以上,5例患者伤口愈合良好,面神经功能部分恢复,无其他功能障碍残留。结论:充分的术前准备和评估,及时有效的探查手术,高效的多学科合作,以及全面的术后管理,可以最大限度地提高颈部穿透性刺伤患者的生命和功能恢复机会。
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引用次数: 0
Research on the correlation between rib fracture characteristics and the risk of intrathoracic and intra-abdominal injuries 肋骨骨折特征与胸、腹内损伤风险的相关性研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.04.002
Hang Cao , Qiang Chen , Yan Ding , Llion Roberts

Purpose

Intrathoracic and intra-abdominal injuries in patients with rib fractures are often overlooked, leading to delayed and ineffective treatment. However, the relationship between rib fractures and organ damage has been rarely studied. The purpose of this study was to analyze the risk factors associated with intrathoracic and intra-abdominal injuries in patients with rib fractures.

Methods

This retrospective observational study included 1269 patients diagnosed with rib fractures from September 2020 to April 2023. Patient data were collected, including gender, age, body mass index, systolic blood pressure, heart rate, type of rib fracture, number of fractured ribs, location of the rib fracture, and the presence of thoracic and abdominal organ injuries. Patients without imaging examinations, the patient with rib fractures from iatrogenic causes or mental illnesses or rheumatic immune diseases was excluded. The primary outcomes were intra-thoracic and intra-abdominal injuries. Multivariate logistic regression analysis was conducted to identify the risk factors for these injuries in patients with rib fractures.

Results

The rib fracture characteristics in the occurrence group included bilateral fractures, higher number of fractures (≥3), and fractures located anteriorly, posteriorly, and laterally, as well as greater fracture displacement, compared to the non-occurrence group. The results of the multivariate logistic regression analysis indicated that age (p=0.016, odds ratio (OR)=0.95, 95% confidence interval (CI: 0.92−0.98), the number of rib fractures (≥3, p=0.001, OR=1.46, 95% CI: 1.13−1.89), rib type (bilateral rib fractures, p=0.043, OR=2.63, 95% CI: 2.16−3.12), and rib fracture location (lateral rib fractures, p=0.041, OR=2.85, 95% CI: 1.31−4.97; posterior rib fractures, p=0.022, OR=3.25, 95% CI: 1.46−6.92) were independent risk factors for thoracic and abdominal organ injuries in patients with traumatic rib fractures.

Conclusions

Patients with rib fractures resulting from blunt trauma, particularly those with lateral or posterior rib fractures, fractures involving more than 3 ribs, and bilateral rib fractures, are at an increased risk for significant intrathoracic and intra-abdominal injuries. These findings warrant attention and the implementation of appropriate preventive measures during treatment.
目的:肋骨骨折患者的胸内、腹内损伤常被忽视,导致治疗延误和无效。然而,肋骨骨折与器官损伤之间的关系很少被研究。本研究的目的是分析肋骨骨折患者胸内和腹内损伤的相关危险因素。方法:本回顾性观察研究纳入了2020年9月至2023年4月诊断为肋骨骨折的1269例患者。收集患者资料,包括性别、年龄、体重指数、收缩压、心率、肋骨骨折类型、肋骨骨折数量、肋骨骨折位置、有无胸腹器官损伤。没有影像学检查的患者、医源性骨折、精神疾病或风湿性免疫疾病的患者被排除在外。主要结局为胸内和腹内损伤。进行多因素logistic回归分析,以确定肋骨骨折患者这些损伤的危险因素。结果:与未发生组相比,发生组肋骨骨折特征为双侧骨折,骨折数≥3例,骨折位于前、后、外侧,骨折移位较大。多因素logistic回归分析结果显示,年龄(p=0.016,优势比(OR)=0.95, 95% CI= 0.92-0.98)、肋骨骨折数量(≥3例,p=0.001, OR=1.46, 95% CI=1.13-1.89)、肋骨类型(双侧肋骨骨折,p=0.043, OR=2.63, 95% CI=2.16-3.12)、肋骨骨折位置(侧肋骨折,p=0.041, OR=2.85, 95% CI=1.31-4.97;后肋骨骨折(p=0.022, OR=3.25, 95% CI=1.46 ~ 6.92)是外伤性肋骨骨折患者胸腹器官损伤的独立危险因素。结论:钝性创伤导致肋骨骨折的患者,特别是伴有侧肋或后肋骨折、超过3根肋骨骨折和双侧肋骨骨折的患者,发生显著胸内和腹内损伤的风险增加。这些发现值得注意,并在治疗期间采取适当的预防措施。
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引用次数: 0
Peri-implant femoral fractures in elderly: Morbidity, mortality, treatment options and good practices 老年人股骨假体周围骨折:发病率、死亡率、治疗选择和良好做法。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2024.07.012
Luca Bianco Prevot , Vittorio Bolcato , Stefania Fozzato , Riccardo Accetta , Michela Basile , Livio Pietro Tronconi , Giuseppe Basile

Purpose

Femur fractures are among the most common fractures treated surgically, representing a significant challenge for the orthopedic surgeon. Peri-implant femoral fractures (PIFFs) represent a rare complication of the surgical treatment. It is necessary to pay attention during osteosynthesis, evaluating not only the fracture site but the entire femoral skeletal structure, the characteristics of the fracture, the health comorbidities, and the risk of malunion and pseudarthrosis. There are few studies on the incidence, treatment, and outcomes of PIFFs near osteosynthesis. This study aimed to investigate PIFF after osteosynthesis of femoral fractures and evaluate the mortality after surgery and the morbidity associated with these types of fractures.

Methods

A retrospective cohort study was carried out at the IRCCS Galeazzi Orthopedic Institute, Milan, Italy, between January, 2017 and December, 2022. Inclusion criteria were the presence of a femur fracture around an intramedullary nail to treat a previous fracture, follow-up ≥ 12 months, and patients aged ≥ 65 years. Exclusion criterion was intraoperative periprosthetic fractures. The data were expressed as frequency and percentage. Continuous variables were expressed as mean ± standard deviation or median and range.

Results

Overall, 25 patients were enrolled (88.0% female) and the mean age was 84.5 years (range of 70 – 92 years). There were 20 patients having type B PIFF and 5 having type C. In 22 patients, multiple comorbidities were found with an average Charlson comorbidity score of 5.5 and the mean time to peri-implant fracture was 38 months. After surgery, 1 patient (4.0%) presented renal failure, 1 (4.0%) needed removal surgery for their loosening, and 2 (8.0%) presented surgical site infection. Nine patients (36.0%) died within 1 year with a mortality rate of 20.0% at 30 days, 8.0% at 3 months, and 8.0% at 12 months.

Conclusions

PIFFs in elderly patients are associated with high short-term mortality and morbidity, so careful planning for primary fracture surgery and patient awareness to ensure prolonged compliance and a healthy lifestyle are essential for prevention.
目的:股骨骨折是外科治疗中最常见的骨折之一,对骨科医生来说是一个重大的挑战。股骨假体周围骨折(PIFFs)是手术治疗中一种罕见的并发症。在植骨过程中要注意,不仅要评估骨折部位,还要评估整个股骨骨骼结构、骨折特征、健康合并症、畸形愈合和假关节的风险。关于骨融合术附近piff的发生率、治疗和结局的研究很少。本研究旨在探讨股骨骨折植骨后的PIFF,并评估其术后死亡率和与此类骨折相关的发病率。方法:回顾性队列研究于2017年1月至2022年12月在意大利米兰的IRCCS Galeazzi骨科研究所进行。纳入标准为既往骨折治疗时髓内钉周围存在股骨骨折,随访≥12个月,患者年龄≥65岁。排除标准为术中假体周围骨折。数据以频率和百分比表示。连续变量以均数±标准差或中位数和极差表示。结果:共纳入25例患者(88.0%为女性),平均年龄为84.5岁(70 - 92岁)。20例患者为B型PIFF, 5例为c型。22例患者存在多种合并症,Charlson合并症平均评分为5.5,平均种植体周围骨折时间为38个月。术后1例(4.0%)出现肾功能衰竭,1例(4.0%)因肾脏松动需要切除,2例(8.0%)出现手术部位感染。1年内死亡9例(36.0%),死亡率为20。30天0%,3个月8.0%,12个月8.0%。结论:老年患者的PIFFs与较高的短期死亡率和发病率相关,因此精心规划原发性骨折手术,患者意识确保长期依从性和健康的生活方式对预防至关重要。
{"title":"Peri-implant femoral fractures in elderly: Morbidity, mortality, treatment options and good practices","authors":"Luca Bianco Prevot ,&nbsp;Vittorio Bolcato ,&nbsp;Stefania Fozzato ,&nbsp;Riccardo Accetta ,&nbsp;Michela Basile ,&nbsp;Livio Pietro Tronconi ,&nbsp;Giuseppe Basile","doi":"10.1016/j.cjtee.2024.07.012","DOIUrl":"10.1016/j.cjtee.2024.07.012","url":null,"abstract":"<div><h3>Purpose</h3><div>Femur fractures are among the most common fractures treated surgically, representing a significant challenge for the orthopedic surgeon. Peri-implant femoral fractures (PIFFs) represent a rare complication of the surgical treatment. It is necessary to pay attention during osteosynthesis, evaluating not only the fracture site but the entire femoral skeletal structure, the characteristics of the fracture, the health comorbidities, and the risk of malunion and pseudarthrosis. There are few studies on the incidence, treatment, and outcomes of PIFFs near osteosynthesis. This study aimed to investigate PIFF after osteosynthesis of femoral fractures and evaluate the mortality after surgery and the morbidity associated with these types of fractures.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was carried out at the IRCCS Galeazzi Orthopedic Institute, Milan, Italy, between January, 2017 and December, 2022. Inclusion criteria were the presence of a femur fracture around an intramedullary nail to treat a previous fracture, follow-up ≥ 12 months, and patients aged ≥ 65 years. Exclusion criterion was intraoperative periprosthetic fractures. The data were expressed as frequency and percentage. Continuous variables were expressed as mean ± standard deviation or median and range.</div></div><div><h3>Results</h3><div>Overall, 25 patients were enrolled (88.0% female) and the mean age was 84.5 years (range of 70 – 92 years). There were 20 patients having type B PIFF and 5 having type C. In 22 patients, multiple comorbidities were found with an average Charlson comorbidity score of 5.5 and the mean time to peri-implant fracture was 38 months. After surgery, 1 patient (4.0%) presented renal failure, 1 (4.0%) needed removal surgery for their loosening, and 2 (8.0%) presented surgical site infection. Nine patients (36.0%) died within 1 year with a mortality rate of 20.0% at 30 days, 8.0% at 3 months, and 8.0% at 12 months.</div></div><div><h3>Conclusions</h3><div>PIFFs in elderly patients are associated with high short-term mortality and morbidity, so careful planning for primary fracture surgery and patient awareness to ensure prolonged compliance and a healthy lifestyle are essential for prevention.</div></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 6","pages":"Pages 497-502"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dental trauma related to orotracheal intubation: Prospective study of 43 cases 43例口气管插管所致牙外伤的前瞻性研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2024.08.007
Yosra Mabrouk , Mohamed Hbib Grissa , Souha ben Youssef

Purpose

Orotracheal intubation is one of the most frequently used techniques in emergency procedures and especially in anesthesia and resuscitation. Teeth may be “victims” of the orotracheal intubation. Several factors may predispose to these accidents. The aim of this study is to determine the incidence of oral trauma that occurs during scheduled and urgent oral tracheal intubation, and identify the risk factors, the types and locations of these dental injuries.

Methods

It is a cross-sectional study that lasted 6 months from June to November 2022. This study was carried out in several departments. An examination of the dental and periodontal status of patients who will undergo surgery under general anesthesia was performed before the operation according to the surgical program. Yet, in emergency settings, this examination was not possible. Patients with anterior edentation and patients refusing participation in the study were excluded. After the surgery, included patients were examined to detect eventual dental trauma such as fracture, luxation, and contusion. Collected data were entered and analyzed using SPSS version 18 software. The Wilcoxon Mann-Whitney U test was used to compare quantitative variables. The Chi-square test was used to compare qualitative variables with a statistical significance level of 5% (p < 0.05).

Results

There were 43 patients included in the study, and dental trauma was noted in 11 patients (25.6%). Their mean age was (59.8 ± 15.4) years. The statistical analysis shows that there is a significant relationship between age (over 40 years old) and trauma (p = 0.004). Among the traumatized group, orotracheal intubation was undergone for 8 cases according to the surgical program whereas it was performed, for 3 cases, in emergency settings. The difference between the 2 types of intervention is statistically significant (p = 0.045). The odds ratio was 0.086 (95% CI: 0.008 – 0.942). A Mallampati score of 1 was rated for 6 injured (54.5%). The difference between the difficulty of the intubation evaluated by the Mallampati score and the occurrence of trauma was statistically insignificant (p = 0.278). The dental partial dislocation was the most frequent trauma (6 cases, 54.5%). The maxillary teeth were the most affected (n = 13, 72.2%).

Conclusion

According to the present study, the incidence of orotracheal intubation dental traumas is relatively high. The age of the patient is one of the factors predisposing to these traumas. In scheduled surgery, orotracheal intubation is quietly performed during general anesthesia, and the risk of incidence of dental trauma is reduced than in emergency settings.
目的:气管插管是急诊手术中最常用的技术之一,特别是在麻醉和复苏中。牙齿可能是气管插管的“受害者”。有几个因素可能导致这些事故的发生。本研究的目的是确定在定期和紧急口腔气管插管中发生的口腔创伤的发生率,并确定这些口腔损伤的危险因素、类型和位置。方法:采用横断面研究方法,于2022年6月至11月进行为期6个月的研究。这项研究是在几个部门进行的。术前应根据手术方案对全麻手术患者的牙齿和牙周状况进行检查。然而,在紧急情况下,这种检查是不可能的。排除有前牙缺的患者和拒绝参加研究的患者。手术后,对纳入的患者进行检查,以发现最终的牙齿创伤,如骨折、脱臼和挫伤。使用SPSS 18版软件对收集到的数据进行录入和分析。采用Wilcoxon Mann-Whitney U检验比较定量变量。采用卡方检验比较定性变量,差异有统计学意义,差异为5% (p)。结果:纳入研究的43例患者中,有11例患者有牙外伤,占25.6%。平均年龄(59.8±15.4)岁。统计分析显示,年龄(40岁以上)与创伤有显著相关(p = 0.004)。在创伤组中,有8例根据手术方案进行了口气管插管,而有3例是在紧急情况下进行的。两种干预方式差异有统计学意义(p = 0.045)。优势比为0.086 (95% CI: 0.008 - 0.942)。6例受伤患者(54.5%)Mallampati评分为1分。Mallampati评分评价插管困难程度与创伤发生率的差异无统计学意义(p = 0.278)。牙部分脱位是最常见的外伤(6例,54.5%)。上颌牙受影响最大(n = 13, 72.2%)。结论:根据目前的研究,口腔气管插管牙外伤的发生率较高。患者的年龄是诱发这些创伤的因素之一。在预定的手术中,在全身麻醉下进行口气管插管,并且发生牙齿创伤的风险比急诊情况下要低。
{"title":"Dental trauma related to orotracheal intubation: Prospective study of 43 cases","authors":"Yosra Mabrouk ,&nbsp;Mohamed Hbib Grissa ,&nbsp;Souha ben Youssef","doi":"10.1016/j.cjtee.2024.08.007","DOIUrl":"10.1016/j.cjtee.2024.08.007","url":null,"abstract":"<div><h3>Purpose</h3><div>Orotracheal intubation is one of the most frequently used techniques in emergency procedures and especially in anesthesia and resuscitation. Teeth may be “victims” of the orotracheal intubation. Several factors may predispose to these accidents. The aim of this study is to determine the incidence of oral trauma that occurs during scheduled and urgent oral tracheal intubation, and identify the risk factors, the types and locations of these dental injuries.</div></div><div><h3>Methods</h3><div>It is a cross-sectional study that lasted 6 months from June to November 2022. This study was carried out in several departments. An examination of the dental and periodontal status of patients who will undergo surgery under general anesthesia was performed before the operation according to the surgical program. Yet, in emergency settings, this examination was not possible. Patients with anterior edentation and patients refusing participation in the study were excluded. After the surgery, included patients were examined to detect eventual dental trauma such as fracture, luxation, and contusion. Collected data were entered and analyzed using SPSS version 18 software. The Wilcoxon Mann-Whitney <em>U</em> test was used to compare quantitative variables. The Chi-square test was used to compare qualitative variables with a statistical significance level of 5% (<em>p</em> &lt; 0.05).</div></div><div><h3>Results</h3><div>There were 43 patients included in the study, and dental trauma was noted in 11 patients (25.6%). Their mean age was (59.8 ± 15.4) years. The statistical analysis shows that there is a significant relationship between age (over 40 years old) and trauma (<em>p</em> = 0.004). Among the traumatized group, orotracheal intubation was undergone for 8 cases according to the surgical program whereas it was performed, for 3 cases, in emergency settings. The difference between the 2 types of intervention is statistically significant (<em>p</em> = 0.045). The odds ratio was 0.086 (95% <em>CI</em>: 0.008 – 0.942). A Mallampati score of 1 was rated for 6 injured (54.5%). The difference between the difficulty of the intubation evaluated by the Mallampati score and the occurrence of trauma was statistically insignificant (<em>p</em> = 0.278). The dental partial dislocation was the most frequent trauma (6 cases, 54.5%). The maxillary teeth were the most affected (<em>n</em> = 13, 72.2%).</div></div><div><h3>Conclusion</h3><div>According to the present study, the incidence of orotracheal intubation dental traumas is relatively high. The age of the patient is one of the factors predisposing to these traumas. In scheduled surgery, orotracheal intubation is quietly performed during general anesthesia, and the risk of incidence of dental trauma is reduced than in emergency settings.</div></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 6","pages":"Pages 491-496"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual cutting-based morphological differences in osteoarthritic and healthy knees: Implications for total knee arthroplasty prosthesis design 骨关节炎和健康膝关节基于虚拟切割的形态差异:全膝关节置换术假体设计的意义。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.08.003
Bin Yu , Yu Zhang , Dongdong Cao , Jinchang Han , Weiyong Wu , Chao Zhang , Aifeng Liu
<div><h3>Purpose</h3><div>End-stage knee osteoarthritis (OA) patients are the primary candidates for total knee arthroplasty (TKA). However, most morphological refinements of TKA prosthesis are based on anatomical data from the knees of healthy individuals. This study aimed to determine whether differences exist in key bony morphological characteristics of the distal femur and proximal tibia between osteoarthritic knees and healthy knees.</div></div><div><h3>Methods</h3><div>This was a retrospective cross-sectional observational study with a case-control design. Patients who were aged ≥ 50 years, had no history of trauma, fracture, or surgery in the studied knee, and had no obvious knee flexion contracture were included in this study by CT scans. Patients who met the American College of Rheumatology clinical criteria for knee OA were included in the study group. Kellgren-Lawrence grade III or IV knees were studied (for bilateral cases, the more severely affected knee was chosen). Patients who presented with unilateral knee pain or trauma were included in the control group, with CT scans from the opposite (asymptomatic) knee used for analyzing. The studied knee had a Kellgren-Lawrence grade of 0 or I and showed no abnormalities upon physical examination. Archived knee CT scans from 160 patients were divided into 2 groups: the study group (80 moderate-to-severe OA knees) and the control group (80 healthy knees). After 3-dimensional reconstruction and virtual cutting using a CT workstation, 13 morphological parameters of the distal femur and proximal tibia were compared between the 2 groups using independent-samples <em>t</em>-tests.</div></div><div><h3>Results</h3><div>No significant group differences in the femoral anteroposterior dimension (<em>p</em> = 0.797), height of the lateral femoral condyle (<em>p</em> = 0.268), posterior condylar angle (<em>p</em> = 0.240), tibial anteroposterior dimension (<em>p</em> = 0.536), or tibial lateral anteroposterior dimension (<em>p</em> = 0.702) were observed. However, the femoral mediolateral dimension (<em>p</em> = 0.002), distal femoral aspect ratio (femoral mediolateral dimension/femoral anteroposterior dimension) (<em>p</em> < 0.001), height of the femoral trochlear groove (<em>p</em> < 0.001), height of the medial femoral condyle (<em>p</em> < 0.001), tibial mediolateral dimension (<em>p</em> = 0.001), proximal tibial aspect ratio (tibial mediolateral dimension/tibial anteroposterior dimension) (<em>p</em> = 0.004), tibial medial anteroposterior dimension (<em>p</em> = 0.005), and tibial asymmetry ratio (tibial medial anteroposterior dimension/tibial lateral anteroposterior dimension) (<em>p</em> = 0.006) were all significantly greater in the study group.</div></div><div><h3>Conclusion</h3><div>Knees with moderate-to-severe OA are significantly wider than healthy knees, and OA is a risk factor for increased tibial platform asymmetry. When refining the morphological parameters of TKA prostheses
目的:终末期膝关节骨性关节炎(OA)患者是全膝关节置换术(TKA)的主要候选者。然而,大多数TKA假体的形态学改进是基于健康个体膝关节的解剖学数据。本研究旨在确定骨关节炎膝关节与健康膝关节在股骨远端和胫骨近端关键骨形态特征上是否存在差异。方法:采用病例对照设计的回顾性横断面观察性研究。年龄≥50岁,所研究膝关节无外伤、骨折或手术史,且CT扫描无明显膝关节屈曲挛缩的患者纳入本研究。符合美国风湿病学会膝关节OA临床标准的患者被纳入研究组。研究了Kellgren-Lawrence III级或IV级膝关节(对于双侧病例,选择影响更严重的膝关节)。出现单侧膝关节疼痛或创伤的患者被纳入对照组,使用对侧(无症状)膝关节的CT扫描进行分析。所研究的膝关节kelgren - lawrence分级为0或I,体格检查未见异常。将160例患者存档的膝关节CT扫描分为两组:研究组(80例中重度OA膝关节)和对照组(80例健康膝关节)。在CT工作站进行三维重建和虚拟切割后,采用独立样本t检验比较两组股骨远端和胫骨近端13个形态学参数。结果:两组患者股骨前位尺寸(p = 0.797)、股骨外侧髁高度(p = 0.268)、后髁角(p = 0.240)、胫骨前位尺寸(p = 0.536)、胫骨外侧前位尺寸(p = 0.702)差异均无统计学意义。然而,股骨内外侧尺寸(p = 0.002)、股骨远端长径比(股内外侧尺寸/股前后方尺寸)(p < 0.001)、股滑车沟高度(p < 0.001)、股内侧髁高度(p < 0.001)、胫骨内外侧尺寸(p = 0.001)、胫骨近端长径比(胫骨内外侧尺寸/胫骨前后方尺寸)(p = 0.004)、胫骨内侧前后方尺寸(p = 0.005)、研究组胫骨不对称比(胫骨内侧前位尺寸/胫骨外侧前位尺寸)(p = 0.006)均显著大于研究组。结论:中重度骨关节炎患者的膝关节明显比健康患者的膝关节宽,骨关节炎是胫骨平台不对称增加的危险因素。在完善TKA假体的形态参数时,应考虑OA膝关节的特定骨形态特征,以减少股骨或胫骨假体下垂的潜在风险,并促进胫骨假体配合和旋转对齐之间的最佳平衡。
{"title":"Virtual cutting-based morphological differences in osteoarthritic and healthy knees: Implications for total knee arthroplasty prosthesis design","authors":"Bin Yu ,&nbsp;Yu Zhang ,&nbsp;Dongdong Cao ,&nbsp;Jinchang Han ,&nbsp;Weiyong Wu ,&nbsp;Chao Zhang ,&nbsp;Aifeng Liu","doi":"10.1016/j.cjtee.2025.08.003","DOIUrl":"10.1016/j.cjtee.2025.08.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;End-stage knee osteoarthritis (OA) patients are the primary candidates for total knee arthroplasty (TKA). However, most morphological refinements of TKA prosthesis are based on anatomical data from the knees of healthy individuals. This study aimed to determine whether differences exist in key bony morphological characteristics of the distal femur and proximal tibia between osteoarthritic knees and healthy knees.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This was a retrospective cross-sectional observational study with a case-control design. Patients who were aged ≥ 50 years, had no history of trauma, fracture, or surgery in the studied knee, and had no obvious knee flexion contracture were included in this study by CT scans. Patients who met the American College of Rheumatology clinical criteria for knee OA were included in the study group. Kellgren-Lawrence grade III or IV knees were studied (for bilateral cases, the more severely affected knee was chosen). Patients who presented with unilateral knee pain or trauma were included in the control group, with CT scans from the opposite (asymptomatic) knee used for analyzing. The studied knee had a Kellgren-Lawrence grade of 0 or I and showed no abnormalities upon physical examination. Archived knee CT scans from 160 patients were divided into 2 groups: the study group (80 moderate-to-severe OA knees) and the control group (80 healthy knees). After 3-dimensional reconstruction and virtual cutting using a CT workstation, 13 morphological parameters of the distal femur and proximal tibia were compared between the 2 groups using independent-samples &lt;em&gt;t&lt;/em&gt;-tests.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;No significant group differences in the femoral anteroposterior dimension (&lt;em&gt;p&lt;/em&gt; = 0.797), height of the lateral femoral condyle (&lt;em&gt;p&lt;/em&gt; = 0.268), posterior condylar angle (&lt;em&gt;p&lt;/em&gt; = 0.240), tibial anteroposterior dimension (&lt;em&gt;p&lt;/em&gt; = 0.536), or tibial lateral anteroposterior dimension (&lt;em&gt;p&lt;/em&gt; = 0.702) were observed. However, the femoral mediolateral dimension (&lt;em&gt;p&lt;/em&gt; = 0.002), distal femoral aspect ratio (femoral mediolateral dimension/femoral anteroposterior dimension) (&lt;em&gt;p&lt;/em&gt; &lt; 0.001), height of the femoral trochlear groove (&lt;em&gt;p&lt;/em&gt; &lt; 0.001), height of the medial femoral condyle (&lt;em&gt;p&lt;/em&gt; &lt; 0.001), tibial mediolateral dimension (&lt;em&gt;p&lt;/em&gt; = 0.001), proximal tibial aspect ratio (tibial mediolateral dimension/tibial anteroposterior dimension) (&lt;em&gt;p&lt;/em&gt; = 0.004), tibial medial anteroposterior dimension (&lt;em&gt;p&lt;/em&gt; = 0.005), and tibial asymmetry ratio (tibial medial anteroposterior dimension/tibial lateral anteroposterior dimension) (&lt;em&gt;p&lt;/em&gt; = 0.006) were all significantly greater in the study group.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Knees with moderate-to-severe OA are significantly wider than healthy knees, and OA is a risk factor for increased tibial platform asymmetry. When refining the morphological parameters of TKA prostheses","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 6","pages":"Pages 436-444"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative laboratory markers as predictors of early spinal surgical site infections: A retrospective cohort study 术后实验室标志物作为早期脊柱手术部位感染的预测因素:一项回顾性队列研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.08.002
Tianhong Chen , Renxin Chen , Hongliang Zhang , Qinyu Feng , Lin Cai , Jingfeng Li

Purpose

To screen laboratory markers with predictive value in early spinal surgical site infections (SSI) that are diagnosed within 30 days postoperatively.

Methods

Patients who underwent surgical treatment for internal spinal fixation between March 2022 and March 2023 in our hospital were retrospectively studied. The inclusion criteria were aged >18 years, undergoing internal fixation surgery, complete medical records with >30 days of postoperative follow-up, diagnosis was made within 30 days postoperatively, and an informed consent form was obtained. The exclusion criteria were abnormal white blood cell count or neutrophil percentage in the preoperative blood routine and combined diseases that may affect the C-reactive protein (CRP) or procalcitonin (PCT) values, including lower respiratory tract infection, renal insufficiency, and liver disease. We collected patients' personal information, surgical information, and blood laboratory data, including CRP, PCT, lymphocyte-neutrophil ratio, platelet-neutrophil ratio, and routine blood tests on preoperative and postoperative days 3, 5, and 7, from these patients. These data were statistically analyzed to determine which laboratory markers were statistically significant. The diagnostic value and optimal diagnostic threshold of these laboratory markers were further determined by receiver operating characteristic curve analysis.

Results

A total of 106 patients were enrolled in this study, of whom 8 patients were diagnosed with early SSI. A total of 4 laboratory markers were screened, namely, CRP on postoperative day 7 (optimal diagnostic threshold of ≥64.1 mg/L, sensitivity of 100%, specificity of 76.5%, area under the curve (AUC) of 0.908), PCT on postoperative day 7 (optimal diagnostic threshold of ≥0.2 ng/mL, sensitivity of 87.5%, specificity of 94.1%, AUC of 0.967), lymphocyte count on postoperative day 5 (optimal diagnostic threshold of ≤0.67 × 109/L, sensitivity of 50%, specificity of 95.9%, AUC of 0.760), and lymphocyte count on postoperative day 7 (optimal diagnostic threshold of ≤1.32 × 109/L, sensitivity of 87.5%, specificity of 55.1%, AUC of 0.721).

Conclusion

We concluded that CRP and PCT levels on postoperative day 7 and lymphocyte counts on postoperative days 5 and 7 are useful markers in screening for early spinal SSI.
目的:筛选对术后30天内诊断为早期脊柱手术部位感染(SSI)具有预测价值的实验室标志物。方法:回顾性分析2022年3月至2023年3月在我院行脊柱内固定手术治疗的患者。纳入标准为:年龄bb0 ~ 18岁,行内固定手术,病历完整,术后随访bb1 ~ 30天,术后30天内确诊,并取得知情同意书。排除标准为术前血常规白细胞计数或中性粒细胞百分比异常,以及可能影响c反应蛋白(CRP)或降钙素原(PCT)值的合并疾病,包括下呼吸道感染、肾功能不全、肝脏疾病。我们收集了患者的个人信息、手术信息和血液实验室数据,包括CRP、PCT、淋巴细胞-中性粒细胞比值、血小板-中性粒细胞比值,以及术前和术后第3、5、7天的血常规。对这些数据进行统计学分析,以确定哪些实验室标记具有统计学意义。通过受试者工作特征曲线分析,进一步确定这些实验室标志物的诊断价值和最佳诊断阈值。结果:本研究共纳入106例患者,其中8例患者被诊断为早期SSI。共筛选4项实验室标志物,即术后第7天CRP(最佳诊断阈值≥64.1 mg/L,灵敏度100%,特异性76.5%,曲线下面积(AUC) 0.908)、术后第7天PCT(最佳诊断阈值≥0.2 ng/mL,灵敏度87.5%,特异性94.1%,AUC 0.967)、术后第5天淋巴细胞计数(最佳诊断阈值≤0.67 × 109/L,灵敏度50%,特异性95.9%,AUC 0.760)、术后第5天淋巴细胞计数(最佳诊断阈值≤0.67 × 109/L,灵敏度50%,特异性95.9%,AUC 0.760)。术后第7天淋巴细胞计数(最佳诊断阈值≤1.32 × 109/L,敏感性87.5%,特异性55.1%,AUC 0.721)。结论:术后第7天的CRP和PCT水平以及术后第5天和第7天的淋巴细胞计数是筛查早期脊柱SSI的有用指标。
{"title":"Postoperative laboratory markers as predictors of early spinal surgical site infections: A retrospective cohort study","authors":"Tianhong Chen ,&nbsp;Renxin Chen ,&nbsp;Hongliang Zhang ,&nbsp;Qinyu Feng ,&nbsp;Lin Cai ,&nbsp;Jingfeng Li","doi":"10.1016/j.cjtee.2025.08.002","DOIUrl":"10.1016/j.cjtee.2025.08.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To screen laboratory markers with predictive value in early spinal surgical site infections (SSI) that are diagnosed within 30 days postoperatively.</div></div><div><h3>Methods</h3><div>Patients who underwent surgical treatment for internal spinal fixation between March 2022 and March 2023 in our hospital were retrospectively studied. The inclusion criteria were aged &gt;18 years, undergoing internal fixation surgery, complete medical records with &gt;30 days of postoperative follow-up, diagnosis was made within 30 days postoperatively, and an informed consent form was obtained. The exclusion criteria were abnormal white blood cell count or neutrophil percentage in the preoperative blood routine and combined diseases that may affect the C-reactive protein (CRP) or procalcitonin (PCT) values, including lower respiratory tract infection, renal insufficiency, and liver disease. We collected patients' personal information, surgical information, and blood laboratory data, including CRP, PCT, lymphocyte-neutrophil ratio, platelet-neutrophil ratio, and routine blood tests on preoperative and postoperative days 3, 5, and 7, from these patients. These data were statistically analyzed to determine which laboratory markers were statistically significant. The diagnostic value and optimal diagnostic threshold of these laboratory markers were further determined by receiver operating characteristic curve analysis.</div></div><div><h3>Results</h3><div>A total of 106 patients were enrolled in this study, of whom 8 patients were diagnosed with early SSI. A total of 4 laboratory markers were screened, namely, CRP on postoperative day 7 (optimal diagnostic threshold of ≥64.1 mg/L, sensitivity of 100%, specificity of 76.5%, area under the curve (AUC) of 0.908), PCT on postoperative day 7 (optimal diagnostic threshold of ≥0.2 ng/mL, sensitivity of 87.5%, specificity of 94.1%, AUC of 0.967), lymphocyte count on postoperative day 5 (optimal diagnostic threshold of ≤0.67 × 10<sup>9</sup>/L, sensitivity of 50%, specificity of 95.9%, AUC of 0.760), and lymphocyte count on postoperative day 7 (optimal diagnostic threshold of ≤1.32 × 10<sup>9</sup>/L, sensitivity of 87.5%, specificity of 55.1%, AUC of 0.721).</div></div><div><h3>Conclusion</h3><div>We concluded that CRP and PCT levels on postoperative day 7 and lymphocyte counts on postoperative days 5 and 7 are useful markers in screening for early spinal SSI.</div></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 6","pages":"Pages 412-417"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between cough peak flow and extubation outcome in patients with acute brain injury: A retrospective cohort study. 急性脑损伤患者咳嗽峰值流量与拔管结果的关系:一项回顾性队列研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.07.002
Min Gao, Xingwen Zhang, Jing Xu, Xiaozhong Kuang, Aijun Jia

Purpose: Cough ability is crucial for extubation in mechanically ventilated acute brain injury (ABI) patients. Cough peak flow (CPF) assesses coughing ability. This study investigates its relationship with extubation outcomes.

Methods: A retrospective cohort study from April 2020 to April 2023 in an intensive care unit ward included mechanically ventilated adult ABI patients on ventilation for at least 24 h. ABI patients were divided by CPF (<60 L/min and ≥60 L/min). Outcomes included extubation success, ventilation days, pneumonia rate, tracheostomy rate, intensive care unit mortality, and length of stay. Multivariable logistic regression analyzed CPF-association with extubation, and receiver operating characteristic curve determined the optimal cutoff.

Results: There were 240 ABI patients included. In the CPF <60L/min group (29 patients), extubation failure after spontaneous breathing trial was 44.8%, median mechanical ventilation time was 3 days, tracheostomy rate was 10.3%, and ventilator-associated pneumonia rate was 20.7%. In the CPF≥60L/min group (211 patients), these were 8.5%, 1 day, 1.4%, and 3.3%, respectively. CPF was significantly associated with extubation failure (adjusted odds ratio: 0.94; 95% confidence intervals (CI): 0.92-0.96; p<0.001). The risk of extubation failure in the group with CPF<60 L/min was 5 times higher than that in the group with CPF≥60 L/min (adjusted odds ratio: 5.0; 95% CI: 2.32-11.11; p<0.001). Receiver operating characteristic analysis identified an optimal cutoff of 68.5 L/min (area under curve=0.829, 95% CI: 0.742-0.916).

Conclusions: CPF is significantly associated with extubation outcome in ABI patients with a successful spontaneous breathing trial.

目的:在机械通气急性脑损伤(ABI)患者中,咳嗽能力对拔管至关重要。咳嗽峰值流量(CPF)评价咳嗽能力。本研究探讨其与拔管结果的关系。方法:2020年4月至2023年4月在重症监护病房进行回顾性队列研究,纳入机械通气至少24小时的成人ABI患者。ABI患者按CPF分组(结果:纳入240例ABI患者)。结论:在自主呼吸试验成功的ABI患者中,CPF与拔管结果显著相关。
{"title":"The relationship between cough peak flow and extubation outcome in patients with acute brain injury: A retrospective cohort study.","authors":"Min Gao, Xingwen Zhang, Jing Xu, Xiaozhong Kuang, Aijun Jia","doi":"10.1016/j.cjtee.2025.07.002","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.07.002","url":null,"abstract":"<p><strong>Purpose: </strong>Cough ability is crucial for extubation in mechanically ventilated acute brain injury (ABI) patients. Cough peak flow (CPF) assesses coughing ability. This study investigates its relationship with extubation outcomes.</p><p><strong>Methods: </strong>A retrospective cohort study from April 2020 to April 2023 in an intensive care unit ward included mechanically ventilated adult ABI patients on ventilation for at least 24 h. ABI patients were divided by CPF (<60 L/min and ≥60 L/min). Outcomes included extubation success, ventilation days, pneumonia rate, tracheostomy rate, intensive care unit mortality, and length of stay. Multivariable logistic regression analyzed CPF-association with extubation, and receiver operating characteristic curve determined the optimal cutoff.</p><p><strong>Results: </strong>There were 240 ABI patients included. In the CPF <60L/min group (29 patients), extubation failure after spontaneous breathing trial was 44.8%, median mechanical ventilation time was 3 days, tracheostomy rate was 10.3%, and ventilator-associated pneumonia rate was 20.7%. In the CPF≥60L/min group (211 patients), these were 8.5%, 1 day, 1.4%, and 3.3%, respectively. CPF was significantly associated with extubation failure (adjusted odds ratio: 0.94; 95% confidence intervals (CI): 0.92-0.96; p<0.001). The risk of extubation failure in the group with CPF<60 L/min was 5 times higher than that in the group with CPF≥60 L/min (adjusted odds ratio: 5.0; 95% CI: 2.32-11.11; p<0.001). Receiver operating characteristic analysis identified an optimal cutoff of 68.5 L/min (area under curve=0.829, 95% CI: 0.742-0.916).</p><p><strong>Conclusions: </strong>CPF is significantly associated with extubation outcome in ABI patients with a successful spontaneous breathing trial.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Explainable machine learning model for predicting septic shock in critically sepsis patients based on coagulation indexes: A multicenter cohort study 基于凝血指标预测重症脓毒症患者脓毒性休克的可解释机器学习模型:一项多中心队列研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2024.08.012
Qing-Bo Zeng , En-Lan Peng , Ye Zhou , Qing-Wei Lin , Lin-Cui Zhong , Long-Ping He , Nian-Qing Zhang , Jing-Chun Song

Purpose

Septic shock is associated with high mortality and poor outcomes among sepsis patients with coagulopathy. Although traditional statistical methods or machine learning (ML) algorithms have been proposed to predict septic shock, these potential approaches have never been systematically compared. The present work aimed to develop and compare models to predict septic shock among patients with sepsis.

Methods

It is a retrospective cohort study based on 484 patients with sepsis who were admitted to our intensive care units between May 2018 and November 2022. Patients from the 908th Hospital of Chinese PLA Logistical Support Force and Nanchang Hongdu Hospital of Traditional Chinese Medicine were respectively allocated to training (n=311) and validation (n=173) sets. All clinical and laboratory data of sepsis patients characterized by comprehensive coagulation indexes were collected. We developed 5 models based on ML algorithms and 1 model based on a traditional statistical method to predict septic shock in the training cohort. The performance of all models was assessed using the area under the receiver operating characteristic curve and calibration plots. Decision curve analysis was used to evaluate the net benefit of the models. The validation set was applied to verify the predictive accuracy of the models. This study also used Shapley additive explanations method to assess variable importance and explain the prediction made by a ML algorithm.

Results

Among all patients, 37.2% experienced septic shock. The characteristic curves of the 6 models ranged from 0.833 to 0.962 and 0.630 to 0.744 in the training and validation sets, respectively. The model with the best prediction performance was based on the support vector machine (SVM) algorithm, which was constructed by age, tissue plasminogen activator-inhibitor complex, prothrombin time, international normalized ratio, white blood cells, and platelet counts. The SVM model showed good calibration and discrimination and a greater net benefit in decision curve analysis.

Conclusion

The SVM algorithm may be superior to other ML and traditional statistical algorithms for predicting septic shock. Physicians can better understand the reliability of the predictive model by Shapley additive explanations value analysis.
目的:脓毒症合并凝血功能障碍患者的脓毒症休克与高死亡率和不良预后相关。虽然传统的统计方法或机器学习(ML)算法已被提出用于预测感染性休克,但这些潜在的方法从未被系统地比较过。目前的工作旨在开发和比较模型来预测脓毒症患者的脓毒性休克。方法:对2018年5月至2022年11月在我院重症监护室住院的484例脓毒症患者进行回顾性队列研究。来自中国人民解放军后勤保障部队908医院和南昌洪都中医医院的患者分别分为训练组(n=311)和验证组(n=173)。收集所有以综合凝血指标为特征的脓毒症患者的临床和实验室资料。我们建立了5个基于ML算法的模型和1个基于传统统计方法的模型来预测训练队列中的脓毒性休克。使用接收机工作特性曲线下的面积和校准图来评估所有模型的性能。决策曲线分析用于评价模型的净效益。验证集用于验证模型的预测准确性。本研究还使用SHapley Additive explained方法来评估变量重要性,并解释ML算法所做的预测。结果:脓毒性休克发生率为37.2%。6个模型在训练集和验证集的特征曲线范围分别为0.833 ~ 0.962和0.630 ~ 0.744。预测效果最好的模型是基于支持向量机(SVM)算法,该模型由年龄、组织纤溶酶原激活物-抑制剂复合物、凝血酶原时间、国际归一化比率、白细胞和血小板计数构建而成。支持向量机模型在决策曲线分析中具有良好的标定和判别能力,具有较高的净效益。结论:SVM算法在脓毒性休克预测方面可能优于其他ML和传统统计算法。通过SHapley加性解释值分析,医生可以更好地理解预测模型的可靠性。
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引用次数: 0
Corrigendum to “Interposition of acellular amniotic membrane at the tendon to bone interface would be better for healing than overlaying above the tendon to bone junction in the repair of rotator cuff injury” [Chinese J Traumatol 28 (2025) 187–192] “在肌腱与骨交界面置入脱细胞羊膜比在肌腱与骨交界面上方覆盖修复肩袖损伤更有利于愈合”的更正[中国创伤杂志28(2025)187-192]。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-11-01 DOI: 10.1016/j.cjtee.2025.09.001
Jiang-Tao Wang , Chun-Bao Li , Jia-Ting Zhang , Ming-Yang An , Gang Zhao , Yu-Jie Liu
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引用次数: 0
期刊
Chinese Journal of Traumatology
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