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Mentors without Borders: Bridging global gaps in medical and radiological education 无国界导师:弥合医学和放射教育方面的全球差距。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2024-12-10 DOI: 10.1067/j.cpradiol.2024.12.005
Monica Pernia Marin , Vikas Burugu , Sofia M. Tarchi , Reza Solemani MD , Mary Salvatore MD, MBA
Pursuing medical careers like radiology is challenging even for those with high levels of commitment, discipline, and resilience. Many rely on the guidance and support from mentors whose experiences serve as the roadmap for new generations. Unfortunately, finding a mentor can be difficult in certain parts of the world or when physicians decide to live and practice medicine outside their country of origin. Within the United States, medical education in the United States is very competitive given the high demand of highly qualified aspirants and the lack of enough training positions to accept them all. Having good mentorship not only can help students enhance the skills required to succeed within their fields of interest during the residency and fellowship application processes, but it can also provide counseling as they navigate training and, ultimately, transition to the workplace. “Mentors without Borders” is a program founded by a radiologist to provide free mentorship to those interested in pursuing medical education and training to pursue radiology and other medical careers in and out of the United States. Its primary focus is on strengthening skills needed for academic writing and publication of scientific articles in radiology. This initiative has already benefited several students and physicians from all over the world and is aiming to become a fully structured program with a larger outreach.
从事像放射学这样的医学事业是具有挑战性的,即使对那些有高度的承诺、纪律和适应力的人来说也是如此。许多人依靠导师的指导和支持,他们的经验可以作为新一代的路线图。不幸的是,在世界某些地区,或者当医生决定在原籍国以外生活和行医时,找到一位导师可能会很困难。在美国,由于对高素质有志者的高需求和缺乏足够的培训职位来接受他们,美国的医学教育竞争非常激烈。有一个好的导师不仅可以帮助学生在实习和奖学金申请过程中提高在他们感兴趣的领域取得成功所需的技能,而且还可以在他们进行培训并最终过渡到工作场所的过程中提供咨询。“无国界导师”是一个由放射科医生创立的项目,为那些有兴趣在美国境内外从事放射学和其他医学职业的医学教育和培训的人提供免费指导。它的主要重点是加强学术写作和发表放射学科学文章所需的技能。这项倡议已经使来自世界各地的几名学生和医生受益,并旨在成为一个具有更大范围的完整结构的项目。
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引用次数: 0
Bilateral internal carotid dissection: advocating for the use of the “googly eyes sign’’ 双侧颈内动脉夹层:提倡使用“斜眼标志”。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2025-04-10 DOI: 10.1067/j.cpradiol.2025.04.001
Nikolaos-Achilleas Arkoudis MD, PhD , Georgios Velonakis MD, PhD
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引用次数: 0
Adipose tissue around the knee; A pictorial review of normal anatomy and common pathologies 膝盖周围的脂肪组织;正常解剖和常见病理的图片回顾。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2024-11-23 DOI: 10.1067/j.cpradiol.2024.11.001
Mohammad Reza Rouhezamin MD (Radiology Research fellow) , Arash Azhideh MD, MPH (Radiology Research fellow) , Sara Haseli MD (Radiology Research fellow) , Atefe Pooyan MD, MPH. (Radiology Research fellow) , Nastaran Hosseini M.D (Radiology Research fellow) , Majid Chalian MD (Associate Professor of Radiology)
The periarticular adipose tissues play a crucial role in knee biomechanics, yet they are often overlooked in daily radiology practice. As the primary mechanical shock absorbers of the knee, intra-articular fat pads reduce the friction between intra-articular structures during joint movement. They also contribute to inflammatory regulation, endocrine secretion, and pain detection. Periarticular fat pads are susceptible to a spectrum of traumatic, degenerative, inflammatory, and neoplastic changes. MRI enables radiologists to assess the anatomy of periarticular fat pads and their related pathologies to make accurate diagnoses and to guide appropriate management. The MRI presentation of these pathologies can be categorized into three groups: (a) signal change and thickening of synovial lining, (b) edema-like change in fat pads, and (c) mass-like lesions. While degeneration and impingement appear as high signal edema-like intensity on fluid-sensitive sequences, inflammatory or infectious synovitis, hemosiderin deposition, and lipoma arborescens can change the signal intensity of the synovial lining. A mass-like lesion arising from these structures could be a true neoplastic lesion, or a variety of non-neoplastic pathologies. A comprehensive understanding of adipose tissues and their pathologies is fundamental for accurate diagnosis and interpretation. In this review, we aim to provide an in-depth assessment of the anatomy and common pathologies of these adipose tissues.
关节周围脂肪组织在膝关节生物力学中起着至关重要的作用,但在日常放射学实践中往往被忽视。作为膝关节的主要机械减震器,关节内脂肪垫减少了关节运动时关节内结构之间的摩擦。它们还参与炎症调节、内分泌分泌和疼痛检测。关节周围脂肪垫易受一系列创伤性、退行性、炎症性和肿瘤性改变的影响。MRI使放射科医生能够评估关节周围脂肪垫的解剖结构及其相关病理,从而做出准确的诊断并指导适当的治疗。这些病理的MRI表现可分为三组:(a)滑膜衬里信号改变和增厚,(b)脂肪垫水肿样改变,(c)肿块样病变。当变性和撞击在液体敏感序列上表现为高信号水肿样强度时,炎症或感染性滑膜炎、含铁血黄素沉积和树状脂肪瘤可改变滑膜衬里的信号强度。由这些结构引起的肿块样病变可能是真正的肿瘤性病变,也可能是非肿瘤性病变。全面了解脂肪组织及其病理是准确诊断和解释的基础。在这篇综述中,我们的目的是对这些脂肪组织的解剖和常见病理进行深入的评估。
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引用次数: 0
Magnetic resonance imaging in paediatric ocular and orbital lesions: A pictorial review 小儿眼部和眼眶病变的磁共振成像:图解综述
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2024-01-18 DOI: 10.1067/j.cpradiol.2024.01.008
Dr. Mankirat Singh Dhillon MBBS , Dr. Jyoti Kumar MD, DNB, MNAMS , Dr. Apoorva Sehgal MD , Dr. Alpana Manchanda MD , Ruchi Goel Dr MS, FAICO, FRCOphth , R.K. Saran Dr MD
Paediatric orbital lesions encompass a wide spectrum of benign and malignant entities that can arise from different components of the orbit. Clinical symptoms and signs are often nonspecific, and imaging plays a crucial role in the diagnosis and management. Ultrasonography has a limited role and radiation is a major concern with CT especially in the paediatric population. MRI is the modality of choice that avoids the radiation hazard and provides superior soft tissue contrast. The lesions can be localized using the ‘compartment’ approach which helps to narrow the list of differentials. MRI also provides critical information for management such as presence of perineural spread and intracranial extension. This article depicts the spectrum of Magnetic Resonance imaging findings encountered in paediatric ocular and orbital lesions.
儿科眼眶病变包括广泛的良性和恶性实体,可由眼眶的不同组成部分产生。临床症状和体征往往是非特异性的,影像学在诊断和治疗中起着至关重要的作用。超声检查的作用有限,尤其是在儿科人群中,CT的主要关注点是辐射。MRI是避免辐射危害和提供优越的软组织对比的首选方式。病变可以使用“隔室”方法进行定位,这有助于缩小差异列表。MRI也为治疗提供关键信息,如有无神经周围扩散和颅内延伸。这篇文章描述的频谱磁共振成像发现遇到的儿童眼窝病变。
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引用次数: 0
Qualitative interviews for hospitalists addressing lung cancer screening 针对医院医生的肺癌筛查定性访谈。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2024-08-14 DOI: 10.1067/j.cpradiol.2024.08.011
Brett C. Bade , Alex Makhnevich , Katherine L. Dauber-Decker , Jeffrey Solomon , Elizabeth Cohn , Jesse Chusid , Suhail Raoof , Gerard Silvestri , Stuart L. Cohen
Novel strategies are needed to improve low rates of lung cancer screening (LCS) in the US. Seeking to determine hospitalists’ perspectives on leveraging hospitalizations to identify patients eligible for LCS, we performed qualitative interviews with eight hospitalists from two hospitals within a large integrated healthcare system. The interviews used semi-structured questions to assess (1) knowledge and practice of general screening and LCS guidelines from the United States Preventive Services Task Force (USPSTF), (2) identification of smoking history, and (3) hospitalists’ views on how data obtained during hospitalization may be utilized to improve general screening and LCS post hospitalization. We ultimately reached the conclusion that hospitalists would support a dedicated program to identify hospitalized patients eligible for LCS and facilitate testing after discharge. Efforts to identify patients and arrange subsequent screening should be performed by team members outside the inpatient team.
美国需要新的策略来改善肺癌筛查(LCS)率低的问题。为了了解医院医生对利用住院治疗来识别符合肺癌筛查条件的患者的看法,我们对一家大型综合医疗系统内两家医院的八名医院医生进行了定性访谈。访谈使用了半结构化问题,以评估(1)对美国预防服务工作组(USPSTF)提供的一般筛查和低碳碳治疗指南的了解和实践,(2)对吸烟史的识别,以及(3)住院医生对如何利用住院期间获得的数据改善一般筛查和住院后低碳碳治疗的看法。我们最终得出的结论是,住院医生将支持一项专门计划,以识别符合 LCS 条件的住院患者,并为出院后的检测提供便利。识别患者和安排后续筛查的工作应由住院团队以外的团队成员执行。
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引用次数: 0
A retrospective analysis of medical student authorship in highest impact radiology journal publications 对医学学生在最具影响力的放射学期刊上发表论文的回顾性分析。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2025-01-27 DOI: 10.1067/j.cpradiol.2025.01.007
Aiman Shahid BSc , Rooshi Parikh BSc , Muhammad Ebrahim Shahid , Aleena Malik BSc , Sonali Sharma BSc , Faisal Khosa MD MBA

Objectives

To assess medical student authorship in radiology research, focusing on the prevalence and impact of student articles, demographic trends, and potential barriers and opportunities for involvement.

Methods

We retrospectively assessed original research and review papers from 2018 to 2022 in the top five radiology journals based on their 2022 Impact Factor. Three reviewers manually validated and classified articles by medical student (MS) and non-MS authorship. Data collected included publication and authorship metrics. Thematic analysis of articles was performed from keywords and SCOPUS topic clusters. Significant associations were identified using chi-squared and two-tailed z-tests.

Results

Of the 2533 publications from all five journals, only 0.47 % were MS-authored, of which 83.3 % had a Field Weighted Citation Impact (FWCI) > 1. Of the 19 MS authors, 68.42 % had prior publications, with the same proportion holding prior first authorship. Female students averaged a higher FWCI (2.47 ± 2.31) but comprised only 26.32 % of all students. Only 16.67 % of MS articles had a female senior author (SA). This was consistent in non-MS articles, with females representing 19.9 % to 25.2 % of SAs across all journals. Of the 2521 non-MS articles, 92 % were classified into themes, revealing that 47.89 % of publications primarily focused on machine learning, while another 42.26 % incorporated some machine learning concepts.

Conclusion

Compared to non-medical student publications in radiology, those by medical students were disproportionately limited but impactful. Both demographic and academic factors hinder student engagement in publishing. Hence promoting, supporting, and sponsoring student involvement in research is pivotal for the discipline.
目的:评估医学生在放射学研究中的作者身份,重点关注学生文章的流行程度和影响、人口趋势以及参与的潜在障碍和机会。方法:根据2022年影响因子对2018 - 2022年前5大放射学期刊的原始研究和综述论文进行回顾性评估。三位审稿人手动验证和分类医学生(MS)和非MS作者的文章。收集的数据包括出版和作者度量。从关键词和SCOPUS主题聚类对文章进行主题分析。使用卡方检验和双尾z检验确定显著关联。结果:5个期刊的2533篇论文中,ms作者仅占0.47%,其中83.3%具有领域加权引文影响(FWCI) bbb1。在19位MS作者中,68.42%的人曾发表过论文,同样比例的人曾是第一作者。女生的FWCI平均值较高(2.47±2.31),但仅占全体学生的26.32%。只有16.67%的MS文章有女性资深作者(SA)。这在非ms文章中也是一致的,在所有期刊中,女性占sa的19.9%至25.2%。在2521篇非ms文章中,92%被分类为主题,这表明47.89%的出版物主要关注机器学习,而另外42.26%的出版物纳入了一些机器学习概念。结论:与非医学生发表的放射学论文相比,医学生发表的论文数量有限,但影响较大。人口统计学和学术因素都阻碍了学生对出版的参与。因此,促进、支持和赞助学生参与研究对该学科至关重要。
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引用次数: 0
Play in the reading room: Utilizing soft modeling compound to teach musculoskeletal anatomy and pathology 阅览室游戏:利用柔软的建模化合物教授肌肉骨骼解剖和病理学。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2023-10-21 DOI: 10.1067/j.cpradiol.2023.10.009
Osvaldo Velez-Martinez M.D , Grant L. Hom BA , Samantha Jayasinghe M.D , Vijaya Kosaraju M.D , Navid Faraji M.D , Jennifer Nicholas M.D , Richard Barger M.D

Problem description

Musculoskeletal (MSK) anatomy and pathology from a radiology perspective can be difficult to conceptualize and understand due to the challenge of visualizing 3D structures in stacks of 2D imaging. Consequently, trainees may benefit from inexpensive methods that can help trainees better visualize MSK anatomy and pathology. The purpose of this study is to provide proof of concept for inexpensive methodology to help learners such as radiology residents quickly and inexpensively understand musculoskeletal anatomy and pathology. This can help trainees become better at applying musculoskeletal knowledge to clinical practice.

Institutional methodology

Soft-modeling compounds such as Play-Doh® was utilized in a variety of colors with pottery tools to recreate 3D models of challenging MSK anatomy and pathology for trainees. Qualitative feedback from the residents was collected.

Results

Eighteen different pathological conditions across six major bone structures were modeled with a soft modeling compound. Residents qualitatively identified the experience as educational in terms of helping them better understand MSK pathology and positive in terms of making learning fun, less stressful, and memorable due to uniqueness of the learning modality. Residents report challenges modeling complex anatomical features and pathology via this methodology.

Conclusion

Radiology residents and other learners can enhance their knowledge of musculoskeletal anatomy and pathology via utilization of inexpensive soft modeling compounds. This may offer a cheaper and more time sensitive alternative to current 3-dimensional hardware and software technologies being developed for educational purposes. Additional work needs to be done to examine the utility of this methodology across larger and diverse groups of learners.
问题描述:由于在2D成像堆栈中可视化3D结构的挑战,从放射学角度来看肌肉骨骼(MSK)解剖和病理学可能很难概念化和理解。因此,受训者可以从廉价的方法中受益,这些方法可以帮助受训者更好地可视化MSK解剖和病理学。本研究的目的是为廉价的方法提供概念证明,以帮助放射学住院医师等学习者快速、廉价地了解肌肉骨骼解剖和病理学。这可以帮助受训者更好地将肌肉骨骼知识应用于临床实践。机构方法:使用各种颜色的软建模化合物,如Play Doh®和陶器工具,为受训人员重建具有挑战性的MSK解剖和病理学的3D模型。收集了居民的定性反馈。结果:用软性建模化合物对六种主要骨结构的18种不同病理状况进行了建模。居民们定性地认为,这段经历在帮助他们更好地理解MSK病理方面具有教育意义,并且由于学习方式的独特性,在使学习变得有趣、压力更小和令人难忘方面具有积极意义。居民报告说,通过这种方法模拟复杂的解剖特征和病理学存在挑战。结论:放射学住院医师和其他学习者可以通过使用廉价的软性建模化合物来提高他们对肌肉骨骼解剖和病理学的知识。这可以为当前为教育目的开发的三维硬件和软件技术提供一种更便宜、更时间敏感的替代方案。需要做更多的工作来检查这种方法在更大和不同的学习群体中的效用。
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引用次数: 0
Musculoskeletal imaging fellowship program directors: A study of educational paths, and scholarly engagement in the United States 肌肉骨骼成像研究金项目主任:美国教育路径和学术参与研究。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2024-10-11 DOI: 10.1067/j.cpradiol.2024.10.007
Mili Rohilla , Shruti Kumar , Parv Mehta , Samruddhi Jain , Abhigyan Bindal , George Vilanilam , Tarun Pandey
<div><h3>Purpose</h3><div>The overall aim of the study is to analyze and provide a comprehensive understanding of the demographics, educational backgrounds, and scholarly activities of musculoskeletal imaging fellowship program directors across the United States.</div></div><div><h3>Methods</h3><div>A list of all members of the Society of Skeletal Radiology was obtained and musculoskeletal imaging fellowship program directors across the US were included. Publicly available online sources were used to gather demographic and educational information about each musculoskeletal imaging fellowship program director, which included the online curriculum vitae from the program websites, Health Grades, Doximity, and Elsevier's Scopus database. Demographic and educational data including age, gender, educational background (medical school, residency, fellowship), additional degrees, academic rank, prior leadership positions, and metrics of scholarly activity were recorded. Fellowships in diagnostic musculoskeletal radiology along with additional degrees were recorded. A two-tailed unpaired t-test was used to calculate the difference between means of scholarly activity between male and female PDs.</div></div><div><h3>Results</h3><div>In this study encompassing 92 programs across the United States, the majority (88) were dedicated to pure Musculoskeletal (MSK) Imaging Fellowship, while one each offered combined training in MSK and Body Imaging, MSK, and Emergency Imaging, MSK Sports, and Interventional Spine, and Pediatric MSK Imaging. Program directors were identified for 90 out of 92 programs, revealing a regional distribution of 29 in the South (31.5 %), 24 in the North East (26.1 %), 20 in the Midwest (21.74 %) and 19 in the West (20.65 %). Gender analysis unveiled a predominantly male representation, with 71 male directors compared to 17 female directors, while age ranged from 30 to 70 years, with a mean age of 47.17 ± 7.4 years. Medical school backgrounds predominantly featured MD degrees (80), followed by IMG (7) and DO (4) degrees, with the most common IMG source being India. Faculty positions were mainly distributed among Assistant Professors (35), Associate Professors (32), and Professors (11). Research output metrics showcased a mean of 41.943 publications and an h-index of 10.625. Extra degrees were obtained by 31 directors, with common additions being other fellowships, MBAs, MS degrees, and PhDs. Notably, some directors held previous or current leadership positions, while a few had completed residencies outside of Radiology or pursued fellowships beyond MSK Imaging.</div></div><div><h3>Conclusion</h3><div>Musculoskeletal imaging fellowship program directors across the United States are predominantly male, with approximately 8 % having graduated from international medical schools. The most common training pathway for these directors is completing a diagnostic radiology residency followed by a musculoskeletal radiology fellowship. This study highli
目的:本研究的总体目标是分析并全面了解全美肌肉骨骼成像研究金项目主任的人口统计学、教育背景和学术活动:我们获得了一份骨骼放射学会所有会员的名单,并将全美的肌肉骨骼成像研究金项目主任纳入其中。利用公开的在线资源收集每位肌肉骨骼成像研究金项目主任的人口统计学和教育信息,其中包括项目网站、Health Grades、Doximity 和 Elsevier 的 Scopus 数据库中的在线简历。记录的人口统计学和教育数据包括年龄、性别、教育背景(医学院、住院医师、研究员)、其他学位、学术排名、曾担任的领导职务以及学术活动指标。此外,还记录了诊断性肌肉骨骼放射学研究员以及其他学位。采用双尾非配对 t 检验来计算男性和女性 PD 之间学术活动平均值的差异:在这项涵盖全美92个项目的研究中,大多数项目(88个)都是纯粹的肌肉骨骼(MSK)成像研究员项目,另有一个项目提供MSK和身体成像、MSK和急诊成像、MSK运动和介入脊柱以及儿科MSK成像的综合培训。在 92 个项目中,有 90 个项目的项目主任被确定,地区分布为南部 29 个(31.5%)、东北部 24 个(26.1%)、中西部 20 个(21.74%)和西部 19 个(20.65%)。性别分析显示,男性主任占绝大多数,男性主任 71 名,女性主任 17 名;年龄从 30 岁到 70 岁不等,平均年龄为 47.17 ± 7.4 岁。医学院背景主要是医学博士(80 人),其次是 IMG(7 人)和 DO(4 人),最常见的 IMG 来源地是印度。教职主要分布在助理教授(35)、副教授(32)和教授(11)中。研究成果指标显示,平均发表论文 41.943 篇,h 指数为 10.625。有 31 位主任获得了额外学位,常见的额外学位包括其他奖学金、工商管理硕士、硕士学位和博士学位。值得注意的是,一些主任曾担任或现任领导职务,还有一些主任完成了放射科以外的住院医师培训,或攻读了 MSK 成像以外的研究金:结论:全美肌肉骨骼成像研究金项目主任以男性为主,约有 8% 毕业于国际医学院。这些主任最常见的培训途径是先完成放射诊断住院医师培训,然后再完成肌肉骨骼放射研究员培训。这项研究突出了这一领导群体中的性别差异,并强调了为肌肉骨骼成像领域做出贡献的不同教育背景。
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引用次数: 0
Tumor mutational burden as a marker for radiologic response to immune checkpoint inhibitors 将肿瘤突变负荷作为免疫检查点抑制剂放射反应的标志物。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2024-12-10 DOI: 10.1067/j.cpradiol.2024.12.010
Dheeman Futela , Sree Harsha Tirumani , Ezgi Guler , Brandon Declouette , Christopher Hoimes , Nikhil H. Ramaiya

Purpose

This study aimed to evaluate the utility of tumor mutational burden (TMB) as a marker for radiologic response to immune checkpoint inhibitor (ICI) therapy at a single tertiary cancer center.

Materials and methods

In this retrospective study, out of 1044 patients treated with ICIs between January 2010 and November 2018, 75 patients (38 males and 37 females) with a mean age of 62 (range 22-87) years, who had information about TMB and adequate imaging, were included. Imaging response was determined according to iRECIST criteria. Predictors of objective response were analysed using non-parametric tests, and progression-free survival and overall survival were analysed using log-rank test.

Results

Median TMB was 7.2 mutations/mb [interquartile range: 4-13.5]. The objective radiologic response rate according to iRECIST was 26.7 % (20 patients) and the median time to best response was 61 days [IQR: 47-88 days]. Median TMB in responders (12.5 [IQR: 5-18] muts/mb) was significantly higher than in non-responders (6 [IQR: 3-12] muts/mb) (p = 0.0293). Median TMB was higher in responders in the subgroup of patients treated with Nivolumab (20 vs 4 muts/mb, P = .0043), but not significantly in those treated with Pembrolizumab (9 vs 6 muts/mb, P = .211). There was no difference in PFS (p = 0.37, Log-Rank) or OS (p = 0.053, Log-Rank) between TMB low and high groups.

Conclusion

Higher TMB was associated with objective response to ICI, however, TMB was an imperfect biomarker for PFS and OS in our study.
目的:本研究旨在评估肿瘤突变负荷(TMB)作为一个单一三级癌症中心对免疫检查点抑制剂(ICI)治疗的放射学反应标志物的效用:在这项回顾性研究中,纳入了2010年1月至2018年11月期间接受ICIs治疗的1044名患者,其中75名患者(38名男性和37名女性)有TMB信息和充分的影像学资料,平均年龄62岁(22-87岁)。根据 iRECIST 标准确定影像学反应。采用非参数检验分析客观反应的预测因素,采用对数秩检验分析无进展生存期和总生存期:TMB中位数为7.2个突变/mb[四分位数间距:4-13.5]。根据iRECIST标准,客观放射学反应率为26.7%(20例患者),最佳反应时间中位数为61天[IQR:47-88天]。有反应者的中位 TMB(12.5 [IQR: 5-18] muts/mb)明显高于无反应者(6 [IQR: 3-12] muts/mb)(p = 0.0293)。在接受 Nivolumab 治疗的患者亚组中,应答者的中位 TMB 较高(20 vs 4 muts/mb,P = .0043),但在接受 Pembrolizumab 治疗的患者亚组中,应答者的中位 TMB 并不明显(9 vs 6 muts/mb,P = .211)。TMB低组和高组间的PFS(P = 0.37,Log-Rank)或OS(P = 0.053,Log-Rank)没有差异:结论:较高的 TMB 与 ICI 的客观反应相关,但在我们的研究中,TMB 并不是 PFS 和 OS 的完美生物标志物。
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引用次数: 0
Improving communication of unexpected findings: The radiology actional findings tracking (RAFT) program 改善意外发现的沟通:放射学动态发现跟踪(RAFT)计划。
IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2025-07-01 Epub Date: 2025-01-23 DOI: 10.1067/j.cpradiol.2025.01.006
Sydney Whalen , Surbhi Trivedi , Josi Herren , Katherine Fuguitt , James T. Bui
Incidental findings are unexpected, actionable discoveries made on diagnostic imaging that have significant patient care and medicolegal implications if not well managed. Despite their importance, few systems exist to manage incidental findings. The Radiology Actionable Findings Tracking (RAFT) Program was developed to improve communication of incidental findings to radiologists, providers, and their patients. The RAFT template is incorporated into the electronic medical record and discloses important information such as: Finding, Acuity, Communication Status, and General Recommendation for follow-up. This data is automatically compiled into a spreadsheet monitored by a clinical coordinator who is responsible for notifying the primary care physician or referring provider. The alert is resolved once appropriate communication is made and the recommended follow-up measures are documented. Between January 2021 and June 2023, the program has tracked the communication of 2,243 incidental findings, for an average of 75 incidental findings each month. Of those total findings, 270 findings (12 %) triggered additional protocols for provider and patient notification with subsequent follow-up. The program is effective in improving communication of incidental findings and can serve as a valuable tool for radiologists, providers, and the patients they serve.
偶然发现是意外的,可操作的发现作出诊断成像,具有重要的病人护理和医学意义,如果管理不善。尽管它们很重要,但很少有系统能够管理偶然发现。制定了放射学可操作发现跟踪(RAFT)计划,以改善与放射科医生,提供者及其患者的偶然发现的沟通。RAFT模板被整合到电子病历中,并公开重要信息,如:发现、急性、沟通状态和一般后续建议。这些数据被自动编译成电子表格,由负责通知初级保健医生或转诊提供者的临床协调员监控。一旦进行了适当的沟通并记录了建议的后续措施,警报就会得到解决。在2021年1月至2023年6月期间,该计划追踪了2243个偶然发现的通信,平均每月有75个偶然发现。在所有这些发现中,270个发现(12%)触发了后续随访中提供者和患者通知的附加协议。该项目有效地改善了意外发现的沟通,可以作为放射科医生、提供者和他们所服务的患者的宝贵工具。
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Current Problems in Diagnostic Radiology
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