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Evaluation of Some Physiological Parameters in Type 2 Diabetes Mellitus Patients With Hypertension and Non-Hypertension According to Body Mass Index 根据体重指数评估高血压和非高血压 2 型糖尿病患者的一些生理参数
Pub Date : 2024-06-15 DOI: 10.55145/ajbms.2024.03.02.09
R. Hashim
Diabetes mellitus (DM) is a common metabolic condition characterized by high blood sugar levels caused by decreased tissue sensitivity to insulin, inadequate insulin synthesis, or a combination of both factors. Insulin Resistance (IR)  enhances the liberation of unbound fatty acids from adipocytes, resulting in elevated levels of circulating unbound fatty acids. The aim of this study is to evaluate some biochemical parameters in the sera of T2DM and compared between T2DM patients with and without hypertension. Material and method: 60 T2DM patients participated in the current study; these patients were split into two groups, 30 T2DM with HP and 30 T2DM without HP. Patient samples were obtained at the Diabetes Research Centre Al-Mustansiriyah University in Baghdad, Iraq, between January and April of 2021. the two study groups in comparison with thirty healthy control subjects. Results: results obtained from this study showed that there is a significant difference in ( Age, BMI, WHR, FBS, HbA1c, TC, TG, HDL, LDL, VLDL, C-peptide, HOMA-IR, Cortisol), while there is non-significant difference in urea and creatinine between patients without HP and control, in the other hand,  there is a significant difference in all parameters determined in this study between T2DM with HP and control. Last but not least, there is a significant difference in WHR, FBS, urea, creatinine , C-Peptide, HOMA-IR and cortisol and there is non-significant difference in the other parameters determined in the study. Conclusion: From the results obtained in this work, it is concluded that the relationship between T2DM and HP is proportional, patients with PH shows higher WHR and FBS and that’s back to the higher body fats, urea and creatinine is significantly increased in patients with HP because of the impair damage in the kidney do to the high pressure, there is direct relationship between age and T2DM infection, the BMI and WHR is one of the most effected risk factors for the injury of T2DM. lipid profile parameters is associated with T2DM because the elevation in the body fat will raise the BMI and WHR and cause insulin resistance that leads to T2DM, renal function parameters will be raise as a response for the damage that effect the nephrons of the kidney, level of C-peptide increased due to the body’s try to keep the level of glucose in the normal range and HOMA-IR is increased because of the insulin resistance occurs in the body . last conclusion is that the level of cortisol is effected by some of inhibitory drugs so it is drop down to a low levels. More studies should be done in this subject to improve the outcomes and find new ways to control and have a good way to diagnose T2DM .
糖尿病(DM)是一种常见的新陈代谢疾病,其特点是由于组织对胰岛素的敏感性降低、胰岛素合成不足或两种因素共同作用而导致高血糖。胰岛素抵抗(IR)会促进脂肪细胞中未结合脂肪酸的释放,导致循环中未结合脂肪酸水平升高。本研究旨在评估 T2DM 血清中的一些生化指标,并对有高血压和无高血压的 T2DM 患者进行比较。材料和方法:60 名 T2DM 患者参与了本次研究;这些患者被分为两组,30 名患有高血压的 T2DM 患者和 30 名不患有高血压的 T2DM 患者。患者样本于 2021 年 1 月至 4 月期间在伊拉克巴格达 Al-Mustansiriyah 大学糖尿病研究中心获得。结果:研究结果显示,未患 HP 的患者与对照组在年龄、体重指数、WHR、FBS、HbA1c、TC、TG、HDL、LDL、VLDL、C-肽、HOMA-IR、皮质醇等指标上存在显著差异,而尿素和肌酐等指标则无显著差异;另一方面,在本研究中测定的所有指标中,患 HP 的 T2DM 患者与对照组均存在显著差异。最后但并非最不重要的一点是,WHR、FBS、尿素、肌酐、C-肽、HOMA-IR 和皮质醇存在显著差异,而研究中测定的其他参数则无显著差异。结论高血压患者的 WHR 和 FBS 较高,这与体内脂肪较高有关;高血压患者的尿素和肌酐明显升高,这是因为高压对肾脏造成了损害;年龄与 T2DM 感染有直接关系;体重指数和 WHR 是影响 T2DM 感染的最主要风险因素之一。血脂谱参数与 T2DM 有关,因为体内脂肪的增加会提高体重指数和 WHR,并导致胰岛素抵抗,从而引发 T2DM;肾功能参数会升高,作为对影响肾小球的损害的反应;C 肽水平升高是因为身体试图将葡萄糖水平保持在正常范围内;HOMA-IR 升高是因为体内发生了胰岛素抵抗。最后的结论是,皮质醇水平受到一些抑制药物的影响,因此会降到较低水平。应该对这一主题进行更多的研究,以改善结果,找到新的控制方法和诊断 T2DM 的好方法。
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引用次数: 0
The Role of Microbiota in Animal Physiology: An Integrative Review 微生物群在动物生理学中的作用:综述
Pub Date : 2024-06-08 DOI: 10.55145/ajbms.2024.03.02.08
A. G. Alshammary, J. Rajab, Rusul A. A. Alshammary
This review examines a broad range of microbiota functions in terms of animal physiology, including its effect on digestion, immunological capabilities, metabolism, reproductive regulation, and nervous system. Its purpose is to provide a systematic overview of on-going research, determine the gap of knowledge and evaluate how environmental factors and the alteration of the microbiome can help to improve the health of animals and contribute to the conservation effort. This study describes the roles of microflora in digestion and absorption of nutrients, modulation of the immune system, and reproduction components and newborn development. Alongside this, it reports the interplay between the bacteria and the central nervous system, which underpins the behavior and mental health. This mission of the review is to offer an integrated overall comprehension of microbiota, which will be used to detect applicable insights and make actionable decisions for future research, veterinary care, and conservation efforts.
这篇综述从动物生理学的角度探讨了微生物群的广泛功能,包括对消化、免疫能力、新陈代谢、生殖调节和神经系统的影响。其目的是对正在进行的研究进行系统概述,确定知识差距,并评估环境因素和微生物组的改变如何有助于改善动物的健康状况并促进动物保护工作。本研究描述了微生物群在营养物质的消化和吸收、免疫系统的调节、繁殖成分和新生儿发育中的作用。此外,它还报告了细菌与中枢神经系统之间的相互作用,而中枢神经系统是行为和心理健康的基础。这篇综述的任务是提供对微生物群的综合全面理解,用于发现适用的见解,并为未来的研究、兽医护理和保护工作做出可行的决定。
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引用次数: 0
Measurement of some immunological Indicators in patients with recurrent oral lichen planus and some viral infections 测量复发性口腔扁平苔藓和某些病毒感染患者的某些免疫指标
Pub Date : 2024-05-21 DOI: 10.55145/ajbms.2024.03.02.05
A. M. Shuker, Mahmood abd Aljabbar ALTobje
Oral lichen planus(OLP) usually appears in the form of skin lesions with multiple oral symptoms. Research indicates that it may be an autoimmune disease and is believed to be related to some viral infections.  aims to determine the level of some immune indicators in patients with OLP and some types of viral infections associated with it. The research also aimed to determine the level of these indicators in patients who suffered from recurrence of the infection. Methods: ELISA technology was used to determine the level of immune indicators, Results the percentage of patients infected with OLP was 48.9%, while those infected with OLP+HCV, OLP+HBsV, and OLP+HSV-1 were 9.4%, 6.2%, and 5.2%, respectively. Some immune indicators are in higher concentrations in females than in males. While there was variation in the levels of some other measured indicators, as they appeared in higher concentrations in patients infected with OLP+HBsV than in other groups, followed by the group of patients infected with OLP+HCV. In the group of patients with OLP, the infection was recurrent at a rate of 93.6%, while the non-recurrence rate was 6.4%. The immune indicators S-IgA, IgG, and C3 each appeared in higher concentrations in non-recurring disease cases, while the rest of the immune indicators appeared in higher concentrations in recurrent cases, and they varied. The levels of these immune indicators in other disease groups under study among those who have recurrence than in the other group. Conclusion: Some immunological indicators are increase in OLP patients and also, in HBsV infections and the disease may be recurrent in same family.
口腔扁平苔藓(OLP)通常以皮损形式出现,伴有多种口腔症状。研究表明,它可能是一种自身免疫性疾病,并被认为与某些病毒感染有关。研究还旨在确定感染复发患者的这些指标水平。研究方法结果显示,感染OLP的患者占48.9%,而感染OLP+HCV、OLP+HBsV和OLP+HSV-1的患者分别占9.4%、6.2%和5.2%。某些免疫指标在女性中的浓度高于男性。其他一些测量指标的水平也存在差异,感染OLP+HBsV的患者体内这些指标的浓度高于其他组别,其次是感染OLP+HCV的患者组别。在 OLP 组患者中,感染复发率为 93.6%,而非复发率为 6.4%。在非复发病例中,免疫指标 S-IgA、IgG 和 C3 的浓度均较高,而在复发病例中,其余免疫指标的浓度均较高,且各不相同。在研究的其他疾病组别中,复发病例的这些免疫指标水平高于其他组别。结论OLP 患者和 HBsV 感染者的某些免疫指标会升高,而且这种疾病可能会在同一家族中复发。
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引用次数: 0
Correlation between Human Boca virus and IL-23in some Iraqi patients with ischemic heart disease 伊拉克部分缺血性心脏病患者体内人类博卡病毒与 IL-23 的相关性
Pub Date : 2024-04-20 DOI: 10.55145/ajbms.2024.03.02.03
Rafal Hussein Alshate, W. S. Abd
Heart diseases in the Iraqi population are a significant public health concern. Iraq has experienced in the prevalence of heart diseases, including coronary artery disease, heart failure and hypertension. Different researches have shown that human Boca virus (HBoV) may be a risk factor, for some cardiac disorders. Hence, goals of resent work is to investigate roles of human Boca virus in ischemia heart disease (IHD) and to investigate roles of serum level of IL-23 in these diseases. 40 heart diseases patients and 40 controls were included. Controls were females (n=30) followed by males (n=10), while patients with IHD were 27 males and 13 females. There were highly significant variations in ages of patients and controls with (p≤0.01). The mean ± SE of age of patients with IHD was 37.90 ±0.75 years, while the mean ± SE of controls was 40.52 ±0.79 years. Lipid profile was measured. There were significant variations between patients' and controls. Also, mean ± SE of HDL was statistically significant between ischemia and control groups (85.28 ±4.31 and 55.10 ±1.23 mg/dl) with p≤0.01, respectively. The serum levels of IgG and IgM were assessed using ELISA. There was no significant variation in mean ± SE of serum level of IgM between ischemia and healthy controls (0.251 ±0.04 and. 0.341 ±0.07 ug/Ml). respectively. There were significant variations in mean ± SE of serum level of IgG between ischemia and controls (0.723 ±0.16 and. 0.076 ±0.004 ug/ml). There were highly significantly differences in Mean ± SE of serum level of 1L-23 between IHD heart diseases (0.407 ±0.073 Pg/mL) and healthy controls (0.0121 ±0.003 pg/mL) with p<0.001, respectively.
伊拉克人的心脏病是一个重大的公共卫生问题。伊拉克的心脏病发病率很高,包括冠状动脉疾病、心力衰竭和高血压。不同的研究表明,人类博卡病毒(HBoV)可能是某些心脏疾病的危险因素。因此,本次研究的目的是调查人类博卡病毒在缺血性心脏病(IHD)中的作用,并调查血清 IL-23 水平在这些疾病中的作用。研究对象包括 40 名心脏病患者和 40 名对照组。对照组为女性(30 人),其次为男性(10 人);缺血性心脏病患者为男性 27 人,女性 13 人。患者和对照组的年龄差异非常明显(P≤0.01)。IHD 患者的平均年龄(±SE)为 37.90 ±0.75 岁,而对照组的平均年龄(±SE)为 40.52 ±0.79 岁。对血脂概况进行了测量。患者与对照组之间存在明显差异。此外,高密度脂蛋白的平均值(±SE)在缺血组和对照组之间有统计学意义(85.28 ±4.31 和 55.10 ±1.23 mg/dl),P≤0.01。血清中的 IgG 和 IgM 水平采用 ELISA 法进行评估。缺血对照组和健康对照组血清中 IgM 的平均值(±SE)分别为 0.251 ±0.04 和 0.341 ±0.07 微克/毫升,无明显差异。缺血患者和对照组血清中 IgG 的平均值(±SE)有明显差异(0.723 ±0.16 和 0.076 ±0.004 微克/毫升)。IHD 心脏病(0.407 ±0.073 Pg/mL)和健康对照组(0.0121 ±0.003 pg/mL)血清中 1L-23 的平均值(±SE)分别有非常明显的差异,P<0.001。
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引用次数: 0
Antibiotics Used in Food Animals: A review 食用动物使用的抗生素:综述
Pub Date : 2024-04-13 DOI: 10.55145/ajbms.2024.03.02.02
Mais Adnan Al_ward, Marwa Adel Hussein Al-Akaidi, Wassan A. Hassan, Asmaa A. Jawad, Daniah M. Hamid, Rana Fadhil Shaher, May Ridha Jaafar, Nadhum H. Safir
Veterinary medications, particularly antibiotics, are crucial elements in the manufacturing of animal feed. Typically, antibiotics are mostly employed in animals for the purpose of treating and preventing infections, as well as promoting growth. The utilization of antibiotics in animals can lead to the presence of antibiotic residues in food products, including milk, eggs, and meat. It is possible for these residues to cause a lot of bad things, like the spread of bacteria that are resistant to antibiotics to humans, immune system problems, allergies, and even cancer (with sulphamethazine, and other drugs). The most harmful consequence of residual drugs is the transfer of resistant antibiotic germs to individuals, aided by the mobility traits of resistance. Controlling the consumption of antibiotics in cattle is imperative in order to mitigate these detrimental effects. The issue should be communicated to individuals and local protocols through formal education. This review will discuss the use of antibiotics in food products and their effects on the health of people.
兽药,尤其是抗生素,是生产动物饲料的关键要素。通常情况下,动物使用抗生素主要是为了治疗和预防感染以及促进生长。在动物体内使用抗生素会导致抗生素残留在食品中,包括牛奶、鸡蛋和肉类。这些残留物有可能导致许多不良后果,如将对抗生素有抗药性的细菌传播给人类、免疫系统问题、过敏,甚至癌症(使用磺胺甲基嘧啶和其他药物)。残留药物最有害的后果是耐药性抗生素病菌在耐药性流动特性的帮助下转移到个人身上。为了减轻这些有害影响,控制牛的抗生素使用量势在必行。应通过正规教育向个人和地方协议传达这一问题。本综述将讨论食品中抗生素的使用及其对人类健康的影响。
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引用次数: 0
Eucalyptus extract and its synergistic effect on bacteria causing urinary tract infections in Diyala province 桉树提取物及其对迪亚拉省尿路感染致病菌的协同作用
Pub Date : 2024-02-12 DOI: 10.55145/ajbms.2024.03.01.010
D. A. Kadhum, E. Hamad, Shahrazad A. Khalaf, E. A. Muhsin
To assess the impact of E. camaldulensis extract against bacteria that are isolated from urine sample from UTI patient in Baquba city Then mix this plant with antibiotics to see its effect. In addition to examine those pathogens bacteriologically. The sensitivity of the isolates to (13) antibiotics was tested, and the bacterial isolates showed a variation in the rates of their resistance to these antibiotics. The results showed that the antibiotic Imipenem had the most effect on the bacterial isolates under study, while the bacterial isolates showed high resistance to the rest of the antibiotics. The minimum inhibitory concentration (MIC) was determined for 3 antibiotics, namely, Gentamycin, Amikacin and Amoxicillin. These values for the antibiotics ranged between <4-1024, <4-1024 <<512-1024) mcg/ml, respectively. The Ethanolic Extract of Eucalyptus Exhibit highest antibacterial effect on S.areus on (o.62 g/1.5 ml and 0.31g/750ml). Lower respectively antibacterial effect on Proteus and Pseudomonas but no antibacterial effect against Klebsiella. Bacterial isolates were selected on the basis of their most frequent urinary tract infections and their resistance to the effect of antibiotics (K. pneumoniae, P. aeruginosa and S. aureus). The amount of the mixed effect was determined by mixing Eucalyptus with three antibiotics, namely Amikacin and Gentamycin Amoxicillin. The minimum inhibitory concentration of the isolates under study was compared before and after mixing the antibiotics. The effect of mixing was a synergistic effect for all bacterial isolates. On the other hand, the synergistic effect was clear on the gram-positive isolates of S. aureus between eucalyptus and beta-lactams (and Amoxicillin).
评估 E. camaldulensis 提取物对从巴古拜市尿毒症患者尿样中分离出的细菌的影响。此外,还要对这些病原体进行细菌学检查。测试了分离菌对(13 种)抗生素的敏感性,细菌分离菌对这些抗生素的耐药率存在差异。结果表明,抗生素亚胺培南对研究中的细菌分离物影响最大,而细菌分离物对其他抗生素的耐药性较高。对 3 种抗生素(即庆大霉素、阿米卡星和阿莫西林)进行了最小抑菌浓度(MIC)测定。这些抗生素的最小抑菌浓度值分别介于<4-1024、<4-1024 <<512-1024) mcg/ml之间。桉树乙醇提取物对变形杆菌的抗菌效果最高(o.62 克/1.5 毫升和 0.31 克/750 毫升)。对变形杆菌和假单胞菌的抗菌效果分别较低,但对克雷伯氏菌没有抗菌效果。选择细菌分离物的依据是它们最常见的尿路感染及其对抗生素的耐药性(肺炎金葡菌、铜绿假单胞菌和金黄色葡萄球菌)。通过将尤加利与三种抗生素(即阿米卡星和庆大霉素阿莫西林)混合,确定了混合效应的量。比较了所研究的分离菌在混合抗生素前后的最低抑菌浓度。混合抗生素对所有细菌分离物都有协同作用。另一方面,桉树和 β-内酰胺类(以及阿莫西林)对革兰氏阳性金黄色葡萄球菌分离物的协同作用非常明显。
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引用次数: 0
Leukemia detection using Artificial Neural Networks in Images of Human Blood Sample 利用人工神经网络检测人体血液样本图像中的白血病
Pub Date : 2024-02-10 DOI: 10.55145/ajbms.2024.03.02.01
Hakar J. Mohamed Salih, J. Arif, Shaimaa Q. Sabri, Ghada A. Taqa, Ahmet Çınar
This article presents a preliminary report that uses minuscule images of blood tests to develop a diagnosis of leukemia. Examining through images is crucial since illnesses can be recognized and examined at an earlier stage using the images. The framework will be centered on leukemia and white blood cell illness. In fact, even the hematologist has trouble organizing the leukemic cells, and manually arranging the platelets takes a long time and is quite loose. In this way, early detection of leukemia recurrence allows the patient to receive the appropriate treatment. In order to address this problem, the framework will make use of the capabilities in small images and examine surface, geometry, shading, and quantifiable investigation modifications. These features' variations will be utilized as the classifier input. has transformed the use of images K proposes that (NN) and agglomeration. Examining a wide range of failure measures and increasing the intricacy of every system, the findings are examined. Utilizing feedforward (NN), image division is accomplished with less noise and a very sluggish conjunction rate. K-means agglomeration and (ANN) are intentionally used in this analysis to create a collection of processes that will work together to produce a much better presentation in (IS). An analysis has been conducted to determine the best rule for (IS).
本文介绍了一份初步报告,该报告利用血液化验的微小图像来诊断白血病。通过图像进行检查至关重要,因为利用图像可以在早期阶段识别和检查疾病。该框架将以白血病和白细胞疾病为中心。事实上,即使是血液学专家也很难整理出白血病细胞,而手动整理血小板则需要很长时间,而且相当松散。这样,及早发现白血病复发,就能让病人接受适当的治疗。为了解决这个问题,该框架将利用小图像的功能,检查表面、几何形状、阴影和可量化的调查修改。这些特征的变化将被用作分类器的输入。对各种故障措施进行了研究,并增加了每个系统的复杂性。利用前馈 (NN),可在噪声较小和结合率非常缓慢的情况下完成图像分割。本分析有意使用 K-均值聚类和(ANN),以创建一个流程集合,共同在(IS)中产生更好的展示效果。我们进行了一项分析,以确定 (IS) 的最佳规则。
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引用次数: 0
Using Ghana's Alternative Medical Healthcare Practice Act 2000 (Act 575) to Evaluate Doctor-Patient Relationship and Medical Negligence Issues Arising from Integration of Artificial Intelligence in Healthcare 利用加纳《2000 年替代性医疗保健实践法》(第 575 号法案)评估医患关系以及人工智能融入医疗保健所引发的医疗过失问题
Pub Date : 2024-01-30 DOI: 10.55145/ajbms.2024.03.01.013
George Benneh Mensah, Maad M. Mijwil, I. Adamopoulos, A. Bardavouras, Fredrick O. Kayusi
This study examines the necessary changes in Ghana’s medical negligence law which governs artificial intelligence (AI) pilots in hospitals to preserve the doctor-patient relationship and address the liability gap by reviewing Law 575, examination of case law. Combined with lessons from Nigerian hospitals and the global literature, practical recommendations result in acceptable changes, provider responsibilities are renewed, patient advocacy in automation Contributions include modeling legal language for maintaining standards of care, limiting algorithmic harm, and advising emerging AIs on diagnosis or treatment.  The need for transparency of equipment and current pilots calls for an update to Rule 575 sooner rather than waiting for crimes to occur. Emphasis is placed on the potential of clinical leaders and policymakers.
本研究通过回顾第 575 号法律和研究判例法,探讨了加纳医疗过失法中对医院人工智能(AI)试点的必要修改,以维护医患关系并解决责任差距问题。结合尼日利亚医院的经验教训和全球文献,实际建议带来了可接受的变化,提供者的责任得到了更新,自动化贡献中的患者宣传包括维护护理标准的法律语言模型、限制算法伤害以及为新兴人工智能的诊断或治疗提供建议。 设备和当前试点的透明度要求尽快更新第 575 条规则,而不是等待犯罪发生。重点在于临床领导者和政策制定者的潜力。
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引用次数: 0
Isolation and Identification of Yeasts from Slaughterhouses in Baghdad province 巴格达省屠宰场酵母菌的分离与鉴定
Pub Date : 2024-01-27 DOI: 10.55145/ajbms.2024.03.01.012
Hayder R. Mashari, Zainab A. A. Al-haddad
The aim of this research was isolation and identification of yeasts from slaughterhouse environment which including  equipment specimens before slaughtered and after slaughtered as well as vital organs swabs in  sheep carcasses were slaughtered  inside of slaughterhouse ,   the specimens were collected in Baghdad province during winter season (2023);and  two hundred (200) samples were collected from abattoirs divided in  to (50) samples before slaughtered and (50) samples after slaughtered and finally another (100) samples were obtained from sheep carcasses which were distributed into twenty-five(25)swabs from each of lung,liver,heart and spleen; these samples were inoculated  on Sabouraud Dextrose Agar (SDA),so the results revealed that the percentage of yeasts isolated before slaughtered was  (52%) while after slaughtered it decreased  to  (42%),while percentage of isolation from vital organs of sheep carcasses (22%) in which most visible in abattoirs environment  C. albicans was in percent of (10%) then  Rhodotorula mucilaginosa was recorded (7.5%) , whereas  after C. parapsilosis appeared in percent of (4.5%)   while Cryptococcus  albidus and C. guilliermondii appeared in percent of(3%)  ; C. famata appeared in percent of (2.5%), both C. zeylanoides and C. sphaerica  were recorded the  same percent of (1%);finally each of C.rugose, C. Lusitaniae ,C.tropicalis, and C. krusei were appeared in percent of (0.5%).
这项研究的目的是从屠宰场环境中分离和鉴定酵母菌,包括屠宰前和屠宰后的设备标本以及屠宰场内屠宰的绵羊尸体的重要器官拭子,标本是在巴格达省冬季(2023 年)采集的;从屠宰场采集了 200 份样本,其中 50 份样本在屠宰前采集,50 份样本在屠宰后采集,最后从绵羊尸体上采集了 100 份样本,分别从肺、肝脏、心脏和脾脏中采集了 25 份拭子;结果显示,屠宰前分离到的酵母菌比例为(52%),屠宰后下降到(42%),而从羊屠体重要器官分离到的酵母菌比例为(22%),其中屠宰场环境中最明显的是白僵菌。白隐球菌(C. albicans)的分离率为(10%),其次是粘液红球菌(Rhodotorula mucilaginosa)(7.5%),然后是副丝状球菌(C. parapsilosis)的分离率为(4.5%),白隐球菌(C. Cryptococcus albidus)和吉利蒙地球菌(C. guilliermondii)的分离率为(3%);C.法马塔隐球菌的出现率为(2.5%),泽兰隐球菌(C. zeylanoides)和斯波里卡隐球菌(C. sphaerica)的出现率同样为(1%);最后,粗毛隐球菌(C. rugose)、卢西塔尼亚隐球菌(C. Lusitaniae)、热带隐球菌(C. tropicalis)和克鲁塞隐球菌(C. krusei)的出现率分别为(0.5%)。
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引用次数: 0
Assessment of the Activity Parameters on Trichomonas vaginalis in Iraqi Women 伊拉克妇女阴道毛滴虫活性参数评估
Pub Date : 2024-01-27 DOI: 10.55145/ajbms.2024.03.01.009
Baraa Ali Mohammed, Ashjan Mohammed Hussein, Ali Hussein Jameel, Prince Opuni Frimpong
Vaginal infections are predominantly caused by Trichomonas vaginalis, bacterial vaginosis, and Candida infection. These infections are particularly concerning among pregnant women, potentially leading to adverse outcomes, including miscarriage. This study aimed to investigate the association between Trichomonas vaginalis infection and hormonal and immune parameters (Vitamin D and Thyroid Stimulating Hormone (TSH) levels). A cross-sectional study was conducted between September 2022 and October 2023. A total of 92 women participated, including 67 patients with recurrent vaginitis (characterized by burning, itching, and discharge) and 25 healthy controls. High vaginal swabs and 5 ml of venous blood were collected from each participant. Serum levels of Vitamin D, TSH, and inflammatory cytokines were measured using immunofluorescence techniques. Women infected with Trichomonas vaginalis had significantly elevated serum Vitamin D levels (P=0.0144), while the differences in TSH levels between the two groups were not statistically significant. Although associations between TSH, Vitamin D, and Trichomonas vaginalis infection were observed, these correlations did not reach statistical significance. This study suggested that Trichomonas vaginalis infection may be associated with increased serum Vitamin D levels in affected women. The lack of a significant change in TSH levels and its weak association with the infection indicate a complex interplay between hormonal balance and vaginal infections. Further research is needed to explore the implications of these findings, particularly in the context of infertility and immune modulation during vaginal infection.
阴道感染主要由阴道毛滴虫、细菌性阴道病和念珠菌感染引起。这些感染在孕妇中尤为严重,有可能导致流产等不良后果。本研究旨在调查阴道毛滴虫感染与激素和免疫参数(维生素 D 和促甲状腺激素(TSH)水平)之间的关系。这项横断面研究于 2022 年 9 月至 2023 年 10 月间进行。共有 92 名妇女参加了这项研究,其中包括 67 名复发性阴道炎患者(以灼热、瘙痒和分泌物为特征)和 25 名健康对照者。每位参与者都采集了高浓度阴道拭子和 5 毫升静脉血。使用免疫荧光技术测量血清中维生素 D、促甲状腺激素和炎症细胞因子的水平。感染阴道毛滴虫的妇女血清维生素 D 水平明显升高(P=0.0144),而两组之间促甲状腺激素水平的差异无统计学意义。虽然观察到促甲状腺激素、维生素 D 和阴道毛滴虫感染之间存在关联,但这些关联未达到统计学意义。这项研究表明,阴道毛滴虫感染可能与受影响妇女的血清维生素 D 水平升高有关。促甲状腺激素(TSH)水平没有明显变化,且与感染的关联性较弱,这表明激素平衡与阴道感染之间存在复杂的相互作用。需要进一步研究来探讨这些发现的意义,特别是在不孕症和阴道感染期间免疫调节方面。
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Al-Salam Journal for Medical Science
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