Pub Date : 2024-12-01Epub Date: 2024-10-15DOI: 10.1016/j.mmcr.2024.100677
Siyue Kan , Lulu Li , Lulu An , Hong Yang , Lianjuan Yang
An 82-year-old female patient presented to our clinic with refractory nailbed ulceration accompanied by pain in her left fourth toe. Six months prior, she had undergone nail removal surgery to address a persistent paronychia that had not resolved for four months. Crust, necrotic tissue, and secretion on the nailbed were taken for microbiological examination, and Candida parapsilosis was discovered in culture. The authors first report one refractory nailbed ulceration caused by Candida parapsilosis after nail extraction.
{"title":"The refractory nailbed ulceration caused by Candida parapsilosis after nail extraction","authors":"Siyue Kan , Lulu Li , Lulu An , Hong Yang , Lianjuan Yang","doi":"10.1016/j.mmcr.2024.100677","DOIUrl":"10.1016/j.mmcr.2024.100677","url":null,"abstract":"<div><div>An 82-year-old female patient presented to our clinic with refractory nailbed ulceration accompanied by pain in her left fourth toe. Six months prior, she had undergone nail removal surgery to address a persistent paronychia that had not resolved for four months. Crust, necrotic tissue, and secretion on the nailbed were taken for microbiological examination, and <em>Candida parapsilosis</em> was discovered in culture. The authors first report one refractory nailbed ulceration caused by <em>Candida parapsilosis</em> after nail extraction.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100677"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-03DOI: 10.1016/j.mmcr.2024.100686
Brenda Aceves-Sánchez , Estefano Rojas-Castañeda , Alfredo Ponce-de-León , Álvaro López- Iñiguez , Andrea Rangel-Cordero , Emilio Sánchez , Noel Salgado-Nesme , María F. González-Lara
We describe two cases of possible healthcare-associated mucormycosis in liver transplant recipients. Mucorales may be acquired from environmental sources such as contaminated medical equipment, grafts or procedure related. Gastrointestinal mucormycosis is the second most common presentation in healthcare-associated infections.
The high mortality rate of mucormycosis is due to low suspicion, insensitive diagnostic tests and rapid angioinvasion. Early antifungal treatment and surgical debridement are imperative to improve survival.
{"title":"Mucormycosis after liver transplant: Case series and literature review","authors":"Brenda Aceves-Sánchez , Estefano Rojas-Castañeda , Alfredo Ponce-de-León , Álvaro López- Iñiguez , Andrea Rangel-Cordero , Emilio Sánchez , Noel Salgado-Nesme , María F. González-Lara","doi":"10.1016/j.mmcr.2024.100686","DOIUrl":"10.1016/j.mmcr.2024.100686","url":null,"abstract":"<div><div>We describe two cases of possible healthcare-associated mucormycosis in liver transplant recipients. Mucorales may be acquired from environmental sources such as contaminated medical equipment, grafts or procedure related. Gastrointestinal mucormycosis is the second most common presentation in healthcare-associated infections.</div><div>The high mortality rate of mucormycosis is due to low suspicion, insensitive diagnostic tests and rapid angioinvasion. Early antifungal treatment and surgical debridement are imperative to improve survival.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100686"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-11-23DOI: 10.1016/j.mmcr.2024.100685
Andrzej Kazimierz Jaworek , Przemysław Hałubiec , Paweł Marcin Krzyściak , Anna Wojas-Pelc , Jadwiga Wójkowska-Mach , Jacek Cezary Szepietowski
We report a case of a 75-year-old male with suspected onychomycosis of the right hand and both feet who also developed kerion-like changes in the skin of his head and neck after recent inguinal hernia surgery. A mycological examination revealed the presence of Trichophyton rubrum in all affected sites. Treatment with oral terbinafine and topical isoconazole nitrate was started, resulting in a significant improvement in skin lesions. The case we present underscores the possibility of autoinoculation transmission of dermatophytes and the need for a careful evaluation of the coexistence of mycoses at different anatomical sites.
{"title":"Kerion-like lesions following an autoinoculation event in patient with chronic onychomycosis – Case report","authors":"Andrzej Kazimierz Jaworek , Przemysław Hałubiec , Paweł Marcin Krzyściak , Anna Wojas-Pelc , Jadwiga Wójkowska-Mach , Jacek Cezary Szepietowski","doi":"10.1016/j.mmcr.2024.100685","DOIUrl":"10.1016/j.mmcr.2024.100685","url":null,"abstract":"<div><div>We report a case of a 75-year-old male with suspected onychomycosis of the right hand and both feet who also developed kerion-like changes in the skin of his head and neck after recent inguinal hernia surgery. A mycological examination revealed the presence of <em>Trichophyton rubrum</em> in all affected sites. Treatment with oral terbinafine and topical isoconazole nitrate was started, resulting in a significant improvement in skin lesions. The case we present underscores the possibility of autoinoculation transmission of dermatophytes and the need for a careful evaluation of the coexistence of mycoses at different anatomical sites.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100685"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-11-16DOI: 10.1016/j.mmcr.2024.100683
Terenzio Cosio , Ruslana Gaeta Shumak , Cristiana Borselli , Fabio Artosi , Roberta Gaziano , Elena Campione
Psoriasis is a multifactorial immune-mediated disorder linked to the interleukin (IL)-17 signalling pathway. We present an unusual case of tinea corporis and faciei caused by Trichophyton tonsurans that developed after starting the IL-17A/F inhibitor bimekizumab. Our case underlines how psoriatic patients, treated with IL-17 inhibitors, should be screened for cutaneous fungal infections before and during treatment, in order to exclude a concomitant infection or the risk of its exacerbation.
{"title":"Challenging case of tinea corporis and faciei in psoriatic patient treated with bimekizumab: The usefulness of mycological screening before biological therapies","authors":"Terenzio Cosio , Ruslana Gaeta Shumak , Cristiana Borselli , Fabio Artosi , Roberta Gaziano , Elena Campione","doi":"10.1016/j.mmcr.2024.100683","DOIUrl":"10.1016/j.mmcr.2024.100683","url":null,"abstract":"<div><div>Psoriasis is a multifactorial immune-mediated disorder linked to the interleukin (IL)-17 signalling pathway. We present an unusual case of <em>tinea corporis</em> and <em>faciei</em> caused by <em>Trichophyton tonsurans</em> that developed after starting the IL-17A/F inhibitor bimekizumab. Our case underlines how psoriatic patients, treated with IL-17 inhibitors, should be screened for cutaneous fungal infections before and during treatment, in order to exclude a concomitant infection or the risk of its exacerbation.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100683"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-10-18DOI: 10.1016/j.mmcr.2024.100676
Kaixuan Yuan , Xiaoxiao Wang , Yong Ling, Ye Long, Zhuoxi Chen, Yunhu Zhao
Fungal peritonitis, an uncommon complication in continuous ambulatory peritoneal dialysis (CAPD), has recently garnered increased attention due to its incidence and potential mortality. To the best of our knowledge, this is the first confirmed case of Neosartorya hiratsukae (N. hiratsukae) causing CAPD-related peritonitis in a patient with chronic nephrotic syndrome in Guangzhou, China. After prompt removal of the peritoneal catheter and active antifungal therapy, no clinical manifestations of peritonitis were observed. Our report underscores the importance of enhancing clinical awareness regarding N. hiratsukae and ensuring timely diagnosis in cases of CAPD-related fungal peritonitis.
{"title":"First case of fungal peritonitis caused by Neosartorya hiratsukae in China","authors":"Kaixuan Yuan , Xiaoxiao Wang , Yong Ling, Ye Long, Zhuoxi Chen, Yunhu Zhao","doi":"10.1016/j.mmcr.2024.100676","DOIUrl":"10.1016/j.mmcr.2024.100676","url":null,"abstract":"<div><div>Fungal peritonitis, an uncommon complication in continuous ambulatory peritoneal dialysis (CAPD), has recently garnered increased attention due to its incidence and potential mortality. To the best of our knowledge, this is the first confirmed case of <em>Neosartorya hiratsukae</em> (<em>N. hiratsukae</em>) causing CAPD-related peritonitis in a patient with chronic nephrotic syndrome in Guangzhou, China. After prompt removal of the peritoneal catheter and active antifungal therapy, no clinical manifestations of peritonitis were observed. Our report underscores the importance of enhancing clinical awareness regarding <em>N. hiratsukae</em> and ensuring timely diagnosis in cases of CAPD-related fungal peritonitis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100676"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-12-04DOI: 10.1016/j.mmcr.2024.100688
Rosemary Barnes , David A. Enoch , Wendy Ingram , Jessica Martin , Jennifer Clay , Netta Tyler , P Lewis White
Refractory invasive fungal disease is a significant clinical problem, with high morbidity, mortality and costs. The complex causes of refractory infection include breakthrough infection due to antifungal resistance (both innate and acquired), suboptimal therapy and impaired immune responses in critically ill or immunocompromised patients. This case series details three reports on the identification and management of refractory fungal infections, two cases of azole resistance and one case of resistant candidiasis, highlighting the importance of accurate diagnosis, monitoring, implementation of biomarkers (serological markers, PCR), antifungal susceptibility testing and antifungal stewardship to optimise management and minimise risks of emergence of drug resistance.
{"title":"Refractory fungal infection: Three case reports highlighting good practice","authors":"Rosemary Barnes , David A. Enoch , Wendy Ingram , Jessica Martin , Jennifer Clay , Netta Tyler , P Lewis White","doi":"10.1016/j.mmcr.2024.100688","DOIUrl":"10.1016/j.mmcr.2024.100688","url":null,"abstract":"<div><div>Refractory invasive fungal disease is a significant clinical problem, with high morbidity, mortality and costs. The complex causes of refractory infection include breakthrough infection due to antifungal resistance (both innate and acquired), suboptimal therapy and impaired immune responses in critically ill or immunocompromised patients. This case series details three reports on the identification and management of refractory fungal infections, two cases of azole resistance and one case of resistant candidiasis, highlighting the importance of accurate diagnosis, monitoring, implementation of biomarkers (serological markers, PCR), antifungal susceptibility testing and antifungal stewardship to optimise management and minimise risks of emergence of drug resistance.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100688"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-09-13DOI: 10.1016/j.mmcr.2024.100668
Oscar E. Gallardo-Huizar , Joyce Lee , Kailyn Kim , Arthur C. Jeng
Miliary coccidioidomycosis is a severe manifestation of diseases caused by Coccidioides immitis and Coccidioides posadasii that is endemic to the southwestern United States as well as Central and South America. While most cases of coccidioidomycosis present with pulmonary disease, certain risk factors increase the risk for disseminated disease. We present a case of miliary coccidioidomycosis in a 46-year-old patient with uncontrolled diabetes. Additionally, we review the features of thirty-seven cases of patients with miliary coccidioidomycosis.
{"title":"Miliary coccidioidomycosis mimicking tuberculosis: Case report and review of literature","authors":"Oscar E. Gallardo-Huizar , Joyce Lee , Kailyn Kim , Arthur C. Jeng","doi":"10.1016/j.mmcr.2024.100668","DOIUrl":"10.1016/j.mmcr.2024.100668","url":null,"abstract":"<div><p>Miliary coccidioidomycosis is a severe manifestation of diseases caused by <em>Coccidioides immitis</em> and <em>Coccidioides posadasii</em> that is endemic to the southwestern United States as well as Central and South America. While most cases of coccidioidomycosis present with pulmonary disease, certain risk factors increase the risk for disseminated disease. We present a case of miliary coccidioidomycosis in a 46-year-old patient with uncontrolled diabetes. Additionally, we review the features of thirty-seven cases of patients with miliary coccidioidomycosis.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100668"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000423/pdfft?md5=156b3f4699098efba953fdf89dab80a2&pid=1-s2.0-S2211753924000423-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fungal infections in marine animals, particularly pinnipeds, have seen a notable increase, often linked to compromised immune systems in captive environments. Trichophyton species, while common in terrestrial mammals, have sporadically caused dermatophytosis in pinnipeds. A South American sea lion (Otaria byronia) presented with Trichophyton benhamiae infection, marking the first such case in this species. Effective treatment combined oral terbinafine with topical ozonized oil, supported by silymarin for liver protection. Accurate fungal identification and sensitivity testing were key to the successful management and recovery of the patient.
{"title":"Dermatophytosis caused by Trichophyton benhamiae in a sea lion. First report","authors":"Ronar López , Víctor Silva , Viviana Bown , Patricio Godoy-Martínez , Pamela Thomson","doi":"10.1016/j.mmcr.2024.100679","DOIUrl":"10.1016/j.mmcr.2024.100679","url":null,"abstract":"<div><div>Fungal infections in marine animals, particularly pinnipeds, have seen a notable increase, often linked to compromised immune systems in captive environments. <em>Trichophyton</em> species, while common in terrestrial mammals, have sporadically caused dermatophytosis in pinnipeds. A South American sea lion (<em>Otaria byronia</em>) presented with <em>Trichophyton benhamiae</em> infection, marking the first such case in this species. Effective treatment combined oral terbinafine with topical ozonized oil, supported by silymarin for liver protection. Accurate fungal identification and sensitivity testing were key to the successful management and recovery of the patient.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100679"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01Epub Date: 2024-09-27DOI: 10.1016/j.mmcr.2024.100672
Wenjie Kang , Jie Zhang , Hanbing Gao , Ming Guan
Invasive fungal otitis media is clinically rare and diagnosis often delayed. We report a 65-year-old female with Aspergillus fumigatus otitis media complicated by mastoiditis and peripheral facial paralysis. Complete mastoidectomy and type II tympanoplasty, with oral administration of voriconazole for more than 3 months resulted in a successful outcome.
侵袭性真菌中耳炎临床罕见，诊断往往被延误。我们报告了一名 65 岁女性的曲霉菌中耳炎，并发乳突炎和周围性面瘫。经过乳突全切除术和 II 型鼓室成形术，并口服伏立康唑 3 个多月后，患者康复出院。
{"title":"Invasive fungal otitis media with peripheral facial paralysis","authors":"Wenjie Kang , Jie Zhang , Hanbing Gao , Ming Guan","doi":"10.1016/j.mmcr.2024.100672","DOIUrl":"10.1016/j.mmcr.2024.100672","url":null,"abstract":"<div><div>Invasive fungal otitis media is clinically rare and diagnosis often delayed. We report a 65-year-old female with <em>Aspergillus fumigatus</em> otitis media complicated by mastoiditis and peripheral facial paralysis. Complete mastoidectomy and type II tympanoplasty, with oral administration of voriconazole for more than 3 months resulted in a successful outcome.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100672"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a case of onychomycosis due to Fusarium solani with gray-green staining, which improved after nail plate removal and antifungal liquid of effinaconazole. Fungal cultures revealed light-brown and dark-green colonies. Gray-green nail might have occurred due to the combination of these colonies, which necessitated differentiation from green nail. Fusarium solani was detected on the genetic analysis of the colonies. Fusarium species reportedly produce yellow or red pigments; however, Fusarium species has not been previously reported to produce green pigments or forming dark-green colonies in fungal cultures.
{"title":"Onychomycosis with gray-green staining caused by Fusarium solani","authors":"Yoshihito Mima , Masako Yamamoto , Koichi Makimura , Ken Iozumi","doi":"10.1016/j.mmcr.2024.100684","DOIUrl":"10.1016/j.mmcr.2024.100684","url":null,"abstract":"<div><div>We report a case of onychomycosis due to Fusarium solani with gray-green staining, which improved after nail plate removal and antifungal liquid of effinaconazole. Fungal cultures revealed light-brown and dark-green colonies. Gray-green nail might have occurred due to the combination of these colonies, which necessitated differentiation from green nail. Fusarium solani was detected on the genetic analysis of the colonies. Fusarium species reportedly produce yellow or red pigments; however, Fusarium species has not been previously reported to produce green pigments or forming dark-green colonies in fungal cultures.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100684"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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