Medical Mycology Case Reports最新文献

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Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review 免疫功能正常患者弥散性皮下孢子虫病：1例报告及系统文献回顾

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-26 DOI: 10.1016/j.mmcr.2025.100739

Guangqi Zhu , Luwen Zhang , Yan Wang , Zheen Zhang

Sporotrichosis is a subacute and chronic infectious disease caused by the infection of the skin, subcutaneous tissues, and nearby lymphatic vessels by the sporotrichosis complex. In this study, we report an immunocompetent case of disseminated subcutaneous sporotrichosis and provide a literature review of all case reports of disseminated subcutaneous sporotrichosis for which species identification was performed. A 74-year-old male patient with normal immune function was diagnosed with disseminated subcutaneous sporotrichosis. Sporadic red masses of varying sizes with local ulceration were observed on his right forearm, wrist, and little finger. Pathology of the mass in the right upper extremity indicated chronic suppurative inflammation of the subcutaneous soft tissue. The mNGS results indicated the presence of Sporothrix schenckii. Following the standard treatment with itraconazole, the patient's skin lesions healed without scarring or pigmentation. Disseminated subcutaneous sporotrichosis is less common in patients with a normal immune function. mNGS testing aids in the clear diagnosis of sporotrichosis and guides antifungal drug selection during treatment.

孢子菌病是一种亚急性和慢性传染病，由孢子菌病复合体感染皮肤、皮下组织和附近淋巴管引起。在这项研究中，我们报告了一例免疫功能正常的播散性皮下孢子虫病，并对所有播散性皮下孢子虫病的病例报告进行了文献回顾，其中进行了物种鉴定。74岁男性，免疫功能正常，诊断为弥散性皮下孢子虫病。在右前臂、手腕和小指可见零星大小不等的红色肿块并伴有局部溃疡。右上肢肿块病理表现为皮下软组织慢性化脓性炎症。mNGS检测结果显示存在申克孢子菌。经伊曲康唑标准治疗后，患者皮肤病变愈合，无瘢痕或色素沉着。播散性皮下孢子菌病在免疫功能正常的患者中较少见。mNGS检测有助于明确孢子菌病的诊断，并指导治疗过程中抗真菌药物的选择。

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引用次数: 0

Recalcitrant dermatophytosis due to Trichophyton indotineae: A case series from Sarawak, Malaysia 印尼毛癣菌引起的顽固性皮肤真菌病：马来西亚沙捞越的病例系列

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-26 DOI: 10.1016/j.mmcr.2025.100740

Xue Ting Tan , Siti Ayesha Siddiqa Saifuddin , Nur Intan Saidaah Mohamed Yusof , Hock Gin Teo , Min Moon Tang

The development of terbinafine-resistant Trichophyton indotineae has made the treatment of dermatophytosis a challenging task globally. We herein report three recalcitrant tinea infections in Sarawak, Malaysia. The ITS sequencing and phylogenetic analysis have confirmed T. indotineae. Furthermore, all isolates carried the Leu393Ser mutation in the SQLE gene, and associated with high terbinafine MICs. However, the voriconazole and itraconazole susceptibilities were variable. The successful azole therapy guided by susceptibility testing (voriconazole/itraconazole) had achieved clinical resolution in one case.

耐特比萘芬的吲哚毛癣菌的发展使全球皮肤癣的治疗成为一项具有挑战性的任务。我们在此报告三个顽固性癣感染在沙捞越，马来西亚。ITS序列分析和系统发育分析证实了该蚊属。此外，所有分离株在SQLE基因中携带Leu393Ser突变，并与高特比萘芬mic相关。伏立康唑和伊曲康唑的敏感性不同。药敏试验指导下的成功治疗（伏立康唑/伊曲康唑）1例获得临床解决。

引用次数: 0

A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome 一例来自非流行地区的犬链球菌肺炎：诊断挑战和成功的治疗结果

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-26 DOI: 10.1016/j.mmcr.2025.100741

Kyle L. Granger Jr. , Benjamin H. Goldblatt , Powell T. Slinkard , Megan A. Stadler , Mei Lun Mui , Charles T. Talbot

A 6-year-old Labrador Retriever presented with fever, cough, and labored breathing. Imaging revealed progressive pneumonia with intrathoracic lymphadenopathy. Initial testing yielded a positive Histoplasma urine antigen; however, fungal culture confirmed Blastomyces helicus. The dog improved on itraconazole, with normalization of clinical signs, C-reactive protein, imaging, and antigen tests. This case highlights diagnostic challenges of cross-reactivity in fungal antigen testing and emphasizes the importance of fungal culture in definitive diagnosis.

一只6岁的拉布拉多猎犬表现出发烧、咳嗽和呼吸困难。影像学显示进行性肺炎伴胸内淋巴结病变。初步检测结果为尿组织浆抗原阳性；真菌培养证实为螺旋芽孢菌。伊曲康唑改善，临床症状、c反应蛋白、影像学和抗原检查正常化。本病例强调了真菌抗原检测中交叉反应性的诊断挑战，并强调了真菌培养在明确诊断中的重要性。

引用次数: 0

Tinea genitalis profunda caused by Microsporum canis: A case report and literature review 犬小孢子虫致生殖器深癣1例并文献复习

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-23 DOI: 10.1016/j.mmcr.2025.100738

Samet Öner, Ceylan Avcı

Deep dermatophytosis in the genital region is rare and often misdiagnosed due to its inflammatory presentation mimicking bacterial or other dermatoses. We report the case of a 23-year-old woman presenting with painful, exudative plaques in the pubogenital area. Initial empirical antibiotic therapy failed. Fungal culture revealed Microsporum canis. Treatment with systemic terbinafine followed by itraconazole led to clinical improvement. The lesion healed with scarring alopecia and post-inflammatory hyperpigmentation. Given the overlapping features with both kerion and Majocchi granuloma, this case was classified as tinea profunda. This case highlights the importance of considering deep dermatophytosis in the differential diagnosis of genital inflammatory and suppurative lesions, especially when initial treatments fail.

在生殖区域的深度皮肤癣是罕见的，经常误诊，因为它的炎症表现模仿细菌或其他皮肤病。我们报告的情况下，一个23岁的妇女提出痛苦，渗出斑块在阴部生殖器区域。最初的经验性抗生素治疗失败。真菌培养显示犬小孢子菌。全身性特比萘芬加伊曲康唑治疗后临床改善。病变愈合后伴有瘢痕性脱发和炎症后色素沉着。考虑到该病例与角质肉芽肿和马氏肉芽肿的重叠特征，该病例被归类为深癣。本病例强调了在生殖器炎症和化脓性病变的鉴别诊断中考虑深部皮肤真菌病的重要性，特别是当初始治疗失败时。

引用次数: 0

Disseminated Scedosporium boydii infection with pulmonary and cerebral involvement in a patient with COPD: A case report 慢性阻塞性肺病患者弥散性波地孢子菌感染并发肺和脑受累1例报告

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-20 DOI: 10.1016/j.mmcr.2025.100737

Parviz Hassanpour , Seyed Jamal Hashemi , Zahra Ramezanalipour , Sanam Nami , Behrooz Naghili

A 51-year-old Iranian man survived a severe respiratory illness but later died from a brain abscess caused by Scedosporium boydii, identified post-mortem. The case highlights the importance of comprehensive care, including adherence to treatment, regular follow-ups, and the use of both culture-based and molecular diagnostics. Incomplete treatment likely contributed to the fatal outcome. A key limitation of this report is the absence of MRI images due to a technical malfunction, preventing further radiological assessment. This case stresses the need for sustained and thorough medical management in complex infections to improve patient outcomes.

一名51岁的伊朗男子从严重的呼吸系统疾病中幸存下来，但后来死于尸检发现的波地塞多孢子虫引起的脑脓肿。该病例强调了全面护理的重要性，包括坚持治疗、定期随访以及同时使用基于培养和分子诊断。不完整的治疗可能导致致命的结果。本报告的一个关键限制是由于技术故障而缺乏MRI图像，从而阻止了进一步的放射学评估。本病例强调需要对复杂感染进行持续和彻底的医疗管理，以改善患者的预后。

引用次数: 0

Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection 双重真菌性心内膜炎的儿童透析患者：黄曲霉和假丝酵母菌共同感染的第一例

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-20 DOI: 10.1016/j.mmcr.2025.100735

Tasneem Shamsi Basha , Amina Bakro , Hari Pankaj Vanam , Akela Ghazawi , Areej AlGhamdi , Fatima Al Dhaheri

We report the first pediatric case of dual fungal infective endocarditis (IE) caused by Aspergillus flavus and Candida parapsilosis in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.

我们报告的第一个儿科病例双重真菌感染性心内膜炎（IE）引起的黄曲霉和假丝酵母傍裂症在透析依赖儿童从冲突影响地区。诊断支持半乳甘露聚糖监测，组织病理学和分子测序。治疗需要早期手术和长期双重抗真菌治疗。尽管这种合并感染罕见且严重，但患者存活了下来。这个病例强调了早期识别、多学科治疗和积极治疗儿童真菌性IE的重要性。

引用次数: 0

Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing Isavuconazole：需要进行治疗药物监测和CYP多态性检测

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-19 DOI: 10.1016/j.mmcr.2025.100736

Rajeev Soman, Sanraksha Mayya, Rahul Doshi, Inderdeep Singh, Sushrut Ganpule

In this patient of invasive sinusitis due to Rhizopus arrhizus, Therapeutic drug monitoring (TDM) showed a high trough level (88mg/L) of isavuconazole on standard doses. Genotyping revealed CYP3A5∗3/∗3 polymorphism which indicated poor metabolism of isavuconazole. Switching to posaconazole was attempted but there was intolerance to posaconazole. To our knowledge, this is the first patient in whom both TDM and CYP genotyping were used to plan very low and infrequent doses of isavuconazole.

本例由阿根霉引起的侵袭性鼻窦炎患者，治疗性药物监测（TDM）显示标准剂量异戊康唑的高波谷水平（88mg/L）。基因分型显示CYP3A5∗3/∗3多态性，表明异唑康唑代谢不良。曾尝试改用泊沙康唑，但患者对泊沙康唑不耐受。据我们所知，这是第一个同时使用TDM和CYP基因分型来计划非常低和不频繁剂量的异唑康唑的患者。

引用次数: 0

Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen 肺移植受者脑脓肿：一种不寻常的真菌病原体引起的意外感染

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-16 DOI: 10.1016/j.mmcr.2025.100727

Raphaël Schils , Michaël Desjardins , Charles Poirier , Hugo Chapdelaine , Marie-Pierre Fournier Gosselin , Philippe J. Dufresne , Me-Linh Luong

Fungal infections are an important cause of morbidity and mortality after lung transplantation. While Aspergillus sp. is the most common implicated organism, rare and emerging molds are increasingly reported. We report a case of Rasamsonia argillacea (formerly Geosmithia argillacea) brain abscess in a lung transplant recipient and highlight the unique characteristics associated with this unusual pathogen.

真菌感染是肺移植术后发病和死亡的重要原因。虽然曲霉是最常见的牵连有机体，罕见和新兴的霉菌越来越多的报道。我们报告一个病例的泥蚶（原泥蚶）脑脓肿在肺移植受体和强调独特的特点与这种不寻常的病原体。

引用次数: 0

Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius) 球蟒体内模拟蛇霉病的Nannizziopsis arthrosporioides感染

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-13 DOI: 10.1016/j.mmcr.2025.100733

Krista A. Keller , Laura Adamovicz , Cathy Johnson-Delaney , Karen A. Terio

A wild caught snake presented with progressive dermatopathy and was euthanized due to a clinical suspicion for ophiomycosis. Over the next 7 days, six additional ball pythons, maintained in the same room but in separate cages from the index case developed similar progressive dermatomycoses and were euthanized. Histopathologic evaluation showed dermal granulomas with intralesional fungi and DNA from the lesions clustered in a monophyletic group with other isolates of N. athrosporioides. Colony and microscopic morphology of fungus from these cases matched published descriptions of N. arthrosporioides. While ophidiomycosis may be a major differential for dermatomycosis in snakes, molecular confirmation should be pursued, as additional fungi may cause similar lesions in this taxon.

一条野生捕获的蛇出现了进行性皮肤病，由于临床怀疑为蛇真菌病而被安乐死。在接下来的7天里，另外6条球蟒，与指示病例保持在同一房间，但在不同的笼子里，出现了类似的进行性皮肤真菌病，并被安乐死。组织病理学评估显示真皮肉芽肿与病灶内真菌和DNA的病变聚集在一个单系组与其他分离的肉毒梭孢杆菌。这些病例真菌的菌落和显微形态与已发表的节孢子奈米菌描述相符。虽然蛇皮菌病可能是蛇皮菌病的主要区别，但应寻求分子证实，因为其他真菌可能在该分类群中引起类似的病变。

引用次数: 0

Disseminated Lichtheimia ramosa infection in a Japanese Black calf 日本黑犊播散性拉莫沙衣原体感染

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports

Pub Date : 2025-09-13 DOI: 10.1016/j.mmcr.2025.100734

Tetsuya Komatsu , Naomi Ito , Yuji Takamura , Kennosuke Sugie , Ami Iwata , Susumu Iwaide , Tomoyuki Shibahara

A female Japanese Black calf with diarrhea and fever was treated unsuccessfully with multiple antibiotics (oxytetracycline, fluorinated quinolones, tylosin, penicillin) and glucocorticoids. Without expecting recovery, the calf was euthanized. On post-mortem examination, the calf had thymus hypoplasia and disseminated mucormycosis with lesions in the liver and gastrointestinal tract. Histologically, multifocal granulomatous lesions with fungal hyphae were detected in the liver and submucosal tissues in the gastrointestinal tract. Lichtheimia ramosa was isolated from the liver. Immunosuppression and antibiotic administration are risk factors for mucormycosis.

用多种抗生素（土霉素、氟喹诺酮类药物、泰洛菌素、青霉素）和糖皮质激素治疗一头患有腹泻和发烧的日本雌性黑犊牛，但均未成功。在没有期望恢复的情况下，小牛被实施了安乐死。在尸检中，小牛胸腺发育不全，并伴有肝脏和胃肠道病变的弥散性毛霉病。组织学上，肝脏和胃肠道粘膜下组织可见多灶性肉芽肿病变伴真菌菌丝。从肝脏中分离出拉莫沙衣原体。免疫抑制和抗生素使用是毛霉病的危险因素。

引用次数: 0

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