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Rare case of a chronic rhinocerebral mucormycosis 罕见的慢性鼻脑粘液瘤病病例
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-09 DOI: 10.1016/j.mmcr.2024.100648
Marie Louise Aicher , Jeanne Bisch-Karatas , Alexander Maurer , Franca Wagner , Martin Wartenberg , Stefan Zimmerli

We describe a case of rhino-orbital-cerebral mucormycosis (ROCM) in a diabetic patient. She presented with cavernous sinus syndrome and ischemia of the optic nerve. Initially unremarkable findings in the nasal cavity and paranasal sinus delayed early diagnosis. Within two weeks, a follow-up MRI showing progressive orbital inflammation, thrombosis of the cavernous sinus and erosive destruction of the left middle nasal concha together with necrotic black tissue in the left nasal cavity and destruction of the maxillary sinus demonstrated in a consecutively performed ethmoidectomy, finally gave way to diagnosis. Definite diagnosis was established by histopathology and culture. Treatment consisted of a combination of liposomal Amphotericin B, partial surgical resection and improved diabetes control. Despite insufficient surgical treatment, the progression of the disease was remarkably slow – a typical hallmark of chronic ROCM.

With this case report we aim to underline the difficulties in establishing a prompt diagnosis of ROCM and to remind readers of its chronic form.

2012 Elsevier Ltd. All rights reserved.

我们描述了一例糖尿病患者的鼻-眶-脑粘液瘤病(ROCM)病例。她出现了海绵窦综合征和视神经缺血。最初鼻腔和副鼻窦的检查结果并不明显,因此延误了早期诊断。在两周内,随访的磁共振成像显示眶内炎症进展、海绵窦血栓形成、左中鼻孔侵蚀性破坏、左鼻腔坏死的黑色组织以及在连续进行的乙状窦切除术中显示的上颌窦破坏,最终为诊断提供了依据。通过组织病理学检查和培养,确定了确诊。治疗包括两性霉素 B 脂质体、部分手术切除和改善糖尿病控制。通过本病例报告,我们希望强调迅速诊断 ROCM 的困难,并提醒读者注意其慢性形式。2012 Elsevier Ltd. 保留所有权利。
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引用次数: 0
Neosartorya udagawae pulmonary infection requiring a surgical treatment in a paediatric haematopoietic progenitor cell recipient 一名造血祖细胞接受者因新沙门氏菌(Neosartorya udagawae)肺部感染而需要手术治疗
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-04 DOI: 10.1016/j.mmcr.2024.100645
Olga S. Tatarinova , Caroline L. Furness , Andrew M. Borman , Joy Barber , Nagarajan Muthialu , Laura Ferreras-Antolin

Neosartorya udagawae is a known cause of fungal infection in humans and animals. It is found to be more refractory to antifungal treatment in comparison to other Aspergillus species. With this report we present a case of proven invasive infection with Neosartorya udagawae in a child with chronic myeloid leukaemia after haematopoietic stem cell transplant. The patient received several lines of antifungal therapy including dual therapy appropriate to the antifungal susceptibility profile with progression of the invasive fungal disease requiring left lung upper lobe lobectomy. The case emphasizes the importance of early biopsy with antifungal susceptibility testing for targeted therapy and demonstrates the potential requirement for surgical management in addition to appropriate antifungal treatment.

Neosartorya udagawae 是导致人类和动物真菌感染的一种已知病原菌。与其他曲霉菌种相比,它对抗真菌治疗更难耐受。在本报告中,我们介绍了一例造血干细胞移植后的慢性髓性白血病患儿经证实感染 Neosartorya udagawae 的病例。患者接受了多种抗真菌治疗,包括适合其抗真菌药敏谱的双重治疗,但由于侵袭性真菌病病情恶化,需要进行左肺上叶切除术。该病例强调了早期活检和抗真菌药敏试验对靶向治疗的重要性,并证明了除适当的抗真菌治疗外,还可能需要手术治疗。
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引用次数: 0
Cutaneous mucormycosis with suspected dissemination in a patient with metastatic adrenocortical carcinoma 一名患有转移性肾上腺皮质癌的患者疑似感染了皮肤粘液瘤病
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-02 DOI: 10.1016/j.mmcr.2024.100646
Nakul Dar , Abigail Wills , Scott Berg , Sarah E. Gradecki , Thomas G. Cropley , Darren Guffey

Mucormycosis is a frequently lethal fungal infection that most commonly affects patients with poorly controlled diabetes or other immunosuppressed states. We report the case of a suspected disseminated Rhizopus infection in a patient who was pursuing naturopathic treatment including mud baths for metastatic adrenocortical carcinoma. He was empirically treated with liposomal amphotericin B but opted to stop treatment following multiorgan failure. The patient passed away on the tenth day of his hospital admission.

粘孢子菌病是一种常见的致命真菌感染,最常见于糖尿病或其他免疫抑制状态控制不佳的患者。我们报告了一例疑似根霉菌播散性感染的病例,患者因转移性肾上腺皮质癌接受自然疗法,包括泥浴治疗。他曾接受脂质体两性霉素 B 的经验性治疗,但在多器官功能衰竭后选择停止治疗。患者在入院第十天去世。
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引用次数: 0
Traumatic implantation keratitis caused by Schizophyllum commune in Central India 印度中部由欧鼠李引起的外伤性植入性角膜炎
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-20 DOI: 10.1016/j.mmcr.2024.100644
Anand Kumar Maurya , Sweta Kumari , Karuna Tadepalli , Bhavna Sharma , Arati Bhadade

We present two cases with a history of trauma to the cornea and after a few days patients developed symptoms of corneal ulcers with one showing hypopyon as well. Due to strong suspicion of fungal keratitis both cases were treated with topical and intravenously voriconazole. Fungal culture showed white fluffy growth which was identified as Schizophyllum commune by conventional and molecular methods. In both cases surgical intervention was essential. Therapeutic keratoplasty was done in both cases but failed. Unfortunately, both patients lost vision in the affected eyes.

我们接诊的两例患者都有角膜外伤史,几天后患者出现了角膜溃疡的症状,其中一人还出现了眼睑下垂。由于强烈怀疑是真菌性角膜炎,两个病例都接受了局部和静脉注射伏立康唑的治疗。真菌培养显示有白色绒毛状生长,通过传统和分子方法鉴定为赤藓菌。这两个病例都必须进行手术治疗。两个病例都进行了治疗性角膜移植手术,但都失败了。不幸的是,两名患者的患眼都失去了视力。
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引用次数: 0
Disseminated Rasamsonia argillacea complex infection presenting as intraventricular brain hemorrhage in a German shepherd dog in Australia 澳大利亚一只德国牧羊犬出现脑室内出血,表现为 Rasamsonia argillacea 复合物播散性感染
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-08 DOI: 10.1016/j.mmcr.2024.100641
Christopher Skinner , Rachel Allavena , Karon Hoffmann , Mirrim Kelly-Bosma , Sarah Kidd , Christine Thomson

A German Shepherd Dog diagnosed with Rasamsonia argillacea based on fungal culture and DNA sequencing, is the first documented case in Australia, and the Southern Hemisphere. This species is part of R. argillacea complex, which is an emerging concern in immunocompromised human and veterinary patients. Intraventricular brain hemorrhage, noted on MRI, has not been reported previously in a dog with fungal encephalitis. The patient was euthanized due to progression of clinical signs before a final diagnosis was made, so no treatment was attempted in this case.

根据真菌培养和 DNA 测序,一只德国牧羊犬被确诊感染了 Rasamsonia argillacea,这是澳大利亚和南半球记录在案的首例病例。该病菌是 R. argillacea 复合菌的一部分,在免疫力低下的人类和兽医患者中正在引起关注。在核磁共振成像中发现的脑室内出血以前从未在患真菌性脑炎的狗身上报道过。在最终确诊前,患者因临床症状恶化而被安乐死,因此没有对该病例进行治疗。
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引用次数: 0
Challenging frontiers: Canine sporotrichosis due to Sporothrix brasiliensis, first case in Chile 挑战前沿:智利首例由巴西孢子虫引起的犬孢子虫病
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-08 DOI: 10.1016/j.mmcr.2024.100632
Ailén Dumont , Carlos González , Belén Rivera , Isidora Mercy , Pamela Thomson

We report the first case of Sporothrix brasiliensis in a dog at Santiago, Chile. From an initial biopsy obtained from the patient, a histopathological study was performed that oriented a fungal infection. The molecular diagnosis from the isolated colony confirmed the identity of the S. brasiliensis agent. Although the literature indicates itraconazole as the first treatment option, the patient was treated with terbinafine followed by itraconazole, without achieving a clinical cure. S. brasiliensis that spread rapidly in Latin America, hence highlight the importance of timely diagnosis that contribute to maintaining human and animal health.

2012 Elsevier Ltd. All rights reserved.

我们报告了智利圣地亚哥的首例狗患巴西孢子虫病的病例。从患者身上获得的最初活组织切片进行了组织病理学研究,结果显示为真菌感染。通过对分离出的菌落进行分子诊断,确认了该病原体的身份。尽管文献指出伊曲康唑是首选治疗方案,但患者在接受特比萘芬治疗后又接受了伊曲康唑治疗,但并未达到临床治愈的效果。因此,及时诊断对维护人类和动物健康非常重要。保留所有权利。
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引用次数: 0
Challenges in the management of severe cutaneous mucormycosis: A case of rapid progression in uncontrolled diabetes mellitus with polymicrobial implications 重症皮肤粘液瘤病的治疗挑战:一例病情迅速恶化且感染多种微生物的糖尿病患者
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-08 DOI: 10.1016/j.mmcr.2024.100643
Sara Harrar , Nidae Mimouni , Rabie Kharchi , Imad Abkari , Awatif El Hakkouni

Mucormycosis, a rare but life-threatening fungal infection, poses significant challenges in clinical management, particularly in patients with uncontrolled diabetes mellitus. This case report presents the clinical journey of a 44-year-old woman who developed a rapidly progressing Mucorales infection following a domestic knife injury. Her condition, complicated by diabetic ketoacidosis and co-infection with Candida albicans, led to severe hand phlegm and sepsis. Despite aggressive intervention, the infection continued to advance, ultimately resulting in the patient’s demise.

粘孢子菌病是一种罕见但危及生命的真菌感染,给临床治疗带来了巨大挑战,尤其是对未得到控制的糖尿病患者。本病例报告介绍了一名 44 岁女性患者的临床病程,她在一次家庭刀伤后发生了进展迅速的粘孢子菌感染。她的病情因糖尿病酮症酸中毒和合并白色念珠菌感染而变得复杂,导致严重的手部痰液和败血症。尽管采取了积极的干预措施,但感染仍在继续发展,最终导致患者死亡。
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引用次数: 0
Beyond conventional approaches: Enhancing photodynamic therapy for refractory feline sporotrichosis caused by Sporothrix brasiliensis 超越传统方法:加强光动力疗法,治疗由巴西孢子虫引起的难治性猫孢子丝虫病
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-06 DOI: 10.1016/j.mmcr.2024.100642
Mariana Lucy Mesquita Ramos , Vanessa Brito de Souza Rabello , Erica Aparecida dos Santos Ribeiro da Silva , Maria Cristina da Silva Lourenço , Rodrigo Almeida-Paes , Susana Frases

Male cat, 2 years old, with a refractory infection by Sporothrix brasiliensis, presents a single nodular lesion in the left auricular pavilion. To confirm the diagnosis, cytology, fungal culture, antifungal susceptibility test, molecular analysis, and, to aid in the differential diagnosis, bacterial culture, antibiogram, and histopathology of the lesion were performed. In the absence of therapeutic success with conventional antifungals, photodynamic therapy (PDT) was introduced, demonstrating a satisfactory response in the sixth treatment session.

雄猫,2 岁,患有难治性巴西孢子菌感染,左侧耳廓出现单个结节性病变。为了确诊,对病灶进行了细胞学检查、真菌培养、抗真菌药敏试验、分子分析,并进行了细菌培养、抗生素造影和组织病理学检查,以帮助鉴别诊断。在使用传统抗真菌药物治疗无效的情况下,患者接受了光动力疗法(PDT),并在第六次治疗中取得了满意的疗效。
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引用次数: 0
Paracoccidioidomycosis after eyebrow micropigmentation: Unusual reactivation or a new form of transmission by cutaneous inoculation? 眉毛持久化妆后的副球孢子菌病:不寻常的再激活还是皮肤接种的新传播形式?
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-06 DOI: 10.1016/j.mmcr.2024.100639
Vítor Falcão de Oliveira, Mariane Taborda, Adriana Satie Gonçalves Kono Magri, Anna Sara Shafferman Levin, Marcello Mihailenko Chaves Magri

We report a case of unusual paracoccidioidomycosis reactivation after eyebrow micropigmentation in a Brazilian patient. The cutaneous lesion was the only clinical manifestation. Direct cutaneous inoculation in dermal tissues with Paracoccidioides sp. is extremely rare, explaining why paracoccidioidomycosis is not classically considered a cutaneous implantation mycosis.

我们报告了一例巴西患者在眉毛持久化妆后重新感染副球孢子菌的不寻常病例。皮肤病变是唯一的临床表现。副球孢子菌在真皮组织中的直接皮肤接种极为罕见,这也解释了为什么副球孢子菌病通常不被认为是一种皮肤种植性真菌病。
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引用次数: 0
Long-term survival following medical management of Aspergillus endocarditis with dissemination as a consequence of steroid therapy in severe COVID-19 pneumonia 重症 COVID-19 肺炎患者在接受类固醇治疗后,因曲霉菌心内膜炎并发播散而接受药物治疗的长期存活率
IF 2.2 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-03-01 DOI: 10.1016/j.mmcr.2024.100638
Kiran G. Kulirankal , Ann Mary , Merlin Moni , Gopal S. Pillai , Dipu T. Sathyapalan

A male in his 40's with no known comorbidities developed severe COVID-19 pneumonia and received a four-week course of methylprednisolone. The patient subsequently developed disseminated Aspergillus endocarditis, manifesting as multiple organ involvement including the heart, eyes, and brain. Despite the poor prognosis generally associated with fungal endocarditis, the patient survived following aggressive medical management with a combination of liposomal amphotericin b and voriconazole therapy and is now doing well for over two years and is off antifungal therapy for a year.

一名 40 多岁的男性患者没有已知的合并症,却患上了严重的 COVID-19 肺炎,并接受了为期四周的甲基强的松龙治疗。患者随后发展为播散性曲霉菌心内膜炎,表现为心脏、眼睛和大脑等多器官受累。尽管真菌性心内膜炎的预后通常较差,但患者在接受了两性霉素 b 脂质体和伏立康唑联合治疗后,经过积极的药物治疗得以存活。
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引用次数: 0
期刊
Medical Mycology Case Reports
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