Pub Date : 2025-09-26DOI: 10.1016/j.mmcr.2025.100741
Kyle L. Granger Jr. , Benjamin H. Goldblatt , Powell T. Slinkard , Megan A. Stadler , Mei Lun Mui , Charles T. Talbot
A 6-year-old Labrador Retriever presented with fever, cough, and labored breathing. Imaging revealed progressive pneumonia with intrathoracic lymphadenopathy. Initial testing yielded a positive Histoplasma urine antigen; however, fungal culture confirmed Blastomyces helicus. The dog improved on itraconazole, with normalization of clinical signs, C-reactive protein, imaging, and antigen tests. This case highlights diagnostic challenges of cross-reactivity in fungal antigen testing and emphasizes the importance of fungal culture in definitive diagnosis.
{"title":"A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome","authors":"Kyle L. Granger Jr. , Benjamin H. Goldblatt , Powell T. Slinkard , Megan A. Stadler , Mei Lun Mui , Charles T. Talbot","doi":"10.1016/j.mmcr.2025.100741","DOIUrl":"10.1016/j.mmcr.2025.100741","url":null,"abstract":"<div><div>A 6-year-old Labrador Retriever presented with fever, cough, and labored breathing. Imaging revealed progressive pneumonia with intrathoracic lymphadenopathy. Initial testing yielded a positive <em>Histoplasma</em> urine antigen; however, fungal culture confirmed <em>Blastomyces helicus</em>. The dog improved on itraconazole, with normalization of clinical signs, C-reactive protein, imaging, and antigen tests. This case highlights diagnostic challenges of cross-reactivity in fungal antigen testing and emphasizes the importance of fungal culture in definitive diagnosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100741"},"PeriodicalIF":1.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-23DOI: 10.1016/j.mmcr.2025.100738
Samet Öner, Ceylan Avcı
Deep dermatophytosis in the genital region is rare and often misdiagnosed due to its inflammatory presentation mimicking bacterial or other dermatoses. We report the case of a 23-year-old woman presenting with painful, exudative plaques in the pubogenital area. Initial empirical antibiotic therapy failed. Fungal culture revealed Microsporum canis. Treatment with systemic terbinafine followed by itraconazole led to clinical improvement. The lesion healed with scarring alopecia and post-inflammatory hyperpigmentation. Given the overlapping features with both kerion and Majocchi granuloma, this case was classified as tinea profunda. This case highlights the importance of considering deep dermatophytosis in the differential diagnosis of genital inflammatory and suppurative lesions, especially when initial treatments fail.
{"title":"Tinea genitalis profunda caused by Microsporum canis: A case report and literature review","authors":"Samet Öner, Ceylan Avcı","doi":"10.1016/j.mmcr.2025.100738","DOIUrl":"10.1016/j.mmcr.2025.100738","url":null,"abstract":"<div><div>Deep dermatophytosis in the genital region is rare and often misdiagnosed due to its inflammatory presentation mimicking bacterial or other dermatoses. We report the case of a 23-year-old woman presenting with painful, exudative plaques in the pubogenital area. Initial empirical antibiotic therapy failed. Fungal culture revealed Microsporum canis. Treatment with systemic terbinafine followed by itraconazole led to clinical improvement. The lesion healed with scarring alopecia and post-inflammatory hyperpigmentation. Given the overlapping features with both kerion and Majocchi granuloma, this case was classified as tinea profunda. This case highlights the importance of considering deep dermatophytosis in the differential diagnosis of genital inflammatory and suppurative lesions, especially when initial treatments fail.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100738"},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 51-year-old Iranian man survived a severe respiratory illness but later died from a brain abscess caused by Scedosporium boydii, identified post-mortem. The case highlights the importance of comprehensive care, including adherence to treatment, regular follow-ups, and the use of both culture-based and molecular diagnostics. Incomplete treatment likely contributed to the fatal outcome. A key limitation of this report is the absence of MRI images due to a technical malfunction, preventing further radiological assessment. This case stresses the need for sustained and thorough medical management in complex infections to improve patient outcomes.
{"title":"Disseminated Scedosporium boydii infection with pulmonary and cerebral involvement in a patient with COPD: A case report","authors":"Parviz Hassanpour , Seyed Jamal Hashemi , Zahra Ramezanalipour , Sanam Nami , Behrooz Naghili","doi":"10.1016/j.mmcr.2025.100737","DOIUrl":"10.1016/j.mmcr.2025.100737","url":null,"abstract":"<div><div>A 51-year-old Iranian man survived a severe respiratory illness but later died from a brain abscess caused by <em>Scedosporium boydii</em>, identified post-mortem. The case highlights the importance of comprehensive care, including adherence to treatment, regular follow-ups, and the use of both culture-based and molecular diagnostics. Incomplete treatment likely contributed to the fatal outcome. A key limitation of this report is the absence of MRI images due to a technical malfunction, preventing further radiological assessment. This case stresses the need for sustained and thorough medical management in complex infections to improve patient outcomes.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100737"},"PeriodicalIF":1.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-20DOI: 10.1016/j.mmcr.2025.100735
Tasneem Shamsi Basha , Amina Bakro , Hari Pankaj Vanam , Akela Ghazawi , Areej AlGhamdi , Fatima Al Dhaheri
We report the first pediatric case of dual fungal infective endocarditis (IE) caused by Aspergillus flavus and Candida parapsilosis in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.
{"title":"Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection","authors":"Tasneem Shamsi Basha , Amina Bakro , Hari Pankaj Vanam , Akela Ghazawi , Areej AlGhamdi , Fatima Al Dhaheri","doi":"10.1016/j.mmcr.2025.100735","DOIUrl":"10.1016/j.mmcr.2025.100735","url":null,"abstract":"<div><div>We report the first pediatric case of dual fungal infective endocarditis (IE) caused by <em>Aspergillus flavus</em> and <em>Candida parapsilosis</em> in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100735"},"PeriodicalIF":1.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this patient of invasive sinusitis due to Rhizopus arrhizus, Therapeutic drug monitoring (TDM) showed a high trough level (88mg/L) of isavuconazole on standard doses. Genotyping revealed CYP3A5∗3/∗3 polymorphism which indicated poor metabolism of isavuconazole. Switching to posaconazole was attempted but there was intolerance to posaconazole. To our knowledge, this is the first patient in whom both TDM and CYP genotyping were used to plan very low and infrequent doses of isavuconazole.
{"title":"Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing","authors":"Rajeev Soman, Sanraksha Mayya, Rahul Doshi, Inderdeep Singh, Sushrut Ganpule","doi":"10.1016/j.mmcr.2025.100736","DOIUrl":"10.1016/j.mmcr.2025.100736","url":null,"abstract":"<div><div>In this patient of invasive sinusitis due to Rhizopus arrhizus, Therapeutic drug monitoring (TDM) showed a high trough level (88mg/L) of isavuconazole on standard doses. Genotyping revealed CYP3A5∗3/∗3 polymorphism which indicated poor metabolism of isavuconazole. Switching to posaconazole was attempted but there was intolerance to posaconazole. To our knowledge, this is the first patient in whom both TDM and CYP genotyping were used to plan very low and infrequent doses of isavuconazole.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100736"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-16DOI: 10.1016/j.mmcr.2025.100727
Raphaël Schils , Michaël Desjardins , Charles Poirier , Hugo Chapdelaine , Marie-Pierre Fournier Gosselin , Philippe J. Dufresne , Me-Linh Luong
Fungal infections are an important cause of morbidity and mortality after lung transplantation. While Aspergillus sp. is the most common implicated organism, rare and emerging molds are increasingly reported. We report a case of Rasamsonia argillacea (formerly Geosmithia argillacea) brain abscess in a lung transplant recipient and highlight the unique characteristics associated with this unusual pathogen.
{"title":"Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen","authors":"Raphaël Schils , Michaël Desjardins , Charles Poirier , Hugo Chapdelaine , Marie-Pierre Fournier Gosselin , Philippe J. Dufresne , Me-Linh Luong","doi":"10.1016/j.mmcr.2025.100727","DOIUrl":"10.1016/j.mmcr.2025.100727","url":null,"abstract":"<div><div>Fungal infections are an important cause of morbidity and mortality after lung transplantation. While Aspergillus sp. is the most common implicated organism, rare and emerging molds are increasingly reported. We report a case of <em>Rasamsonia argillacea</em> (formerly <em>Geosmithia argillacea</em>) brain abscess in a lung transplant recipient and highlight the unique characteristics associated with this unusual pathogen.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100727"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-13DOI: 10.1016/j.mmcr.2025.100733
Krista A. Keller , Laura Adamovicz , Cathy Johnson-Delaney , Karen A. Terio
A wild caught snake presented with progressive dermatopathy and was euthanized due to a clinical suspicion for ophiomycosis. Over the next 7 days, six additional ball pythons, maintained in the same room but in separate cages from the index case developed similar progressive dermatomycoses and were euthanized. Histopathologic evaluation showed dermal granulomas with intralesional fungi and DNA from the lesions clustered in a monophyletic group with other isolates of N. athrosporioides. Colony and microscopic morphology of fungus from these cases matched published descriptions of N. arthrosporioides. While ophidiomycosis may be a major differential for dermatomycosis in snakes, molecular confirmation should be pursued, as additional fungi may cause similar lesions in this taxon.
{"title":"Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius)","authors":"Krista A. Keller , Laura Adamovicz , Cathy Johnson-Delaney , Karen A. Terio","doi":"10.1016/j.mmcr.2025.100733","DOIUrl":"10.1016/j.mmcr.2025.100733","url":null,"abstract":"<div><div>A wild caught snake presented with progressive dermatopathy and was euthanized due to a clinical suspicion for ophiomycosis. Over the next 7 days, six additional ball pythons, maintained in the same room but in separate cages from the index case developed similar progressive dermatomycoses and were euthanized. Histopathologic evaluation showed dermal granulomas with intralesional fungi and DNA from the lesions clustered in a monophyletic group with other isolates of <em>N. athrosporioides</em>. Colony and microscopic morphology of fungus from these cases matched published descriptions of <em>N. arthrosporioides</em>. While ophidiomycosis may be a major differential for dermatomycosis in snakes, molecular confirmation should be pursued, as additional fungi may cause similar lesions in this taxon.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100733"},"PeriodicalIF":1.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-13DOI: 10.1016/j.mmcr.2025.100734
Tetsuya Komatsu , Naomi Ito , Yuji Takamura , Kennosuke Sugie , Ami Iwata , Susumu Iwaide , Tomoyuki Shibahara
A female Japanese Black calf with diarrhea and fever was treated unsuccessfully with multiple antibiotics (oxytetracycline, fluorinated quinolones, tylosin, penicillin) and glucocorticoids. Without expecting recovery, the calf was euthanized. On post-mortem examination, the calf had thymus hypoplasia and disseminated mucormycosis with lesions in the liver and gastrointestinal tract. Histologically, multifocal granulomatous lesions with fungal hyphae were detected in the liver and submucosal tissues in the gastrointestinal tract. Lichtheimia ramosa was isolated from the liver. Immunosuppression and antibiotic administration are risk factors for mucormycosis.
{"title":"Disseminated Lichtheimia ramosa infection in a Japanese Black calf","authors":"Tetsuya Komatsu , Naomi Ito , Yuji Takamura , Kennosuke Sugie , Ami Iwata , Susumu Iwaide , Tomoyuki Shibahara","doi":"10.1016/j.mmcr.2025.100734","DOIUrl":"10.1016/j.mmcr.2025.100734","url":null,"abstract":"<div><div>A female Japanese Black calf with diarrhea and fever was treated unsuccessfully with multiple antibiotics (oxytetracycline, fluorinated quinolones, tylosin, penicillin) and glucocorticoids. Without expecting recovery, the calf was euthanized. On post-mortem examination, the calf had thymus hypoplasia and disseminated mucormycosis with lesions in the liver and gastrointestinal tract. Histologically, multifocal granulomatous lesions with fungal hyphae were detected in the liver and submucosal tissues in the gastrointestinal tract. <em>Lichtheimia ramosa</em> was isolated from the liver. Immunosuppression and antibiotic administration are risk factors for mucormycosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100734"},"PeriodicalIF":1.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mucormycosis is an angio-invasive, opportunistic fungal infection, which usually affects individuals with poorly controlled diabetes mellitus. While rhino-orbital-cerebral mucormycosis (ROCM) has been described in the English language literature, odontogenic-onset mucormycosis (OOM) is an emerging clinical entity, which is characterized by a unique port of entry, a distinct mode of onset and clinic-radiological features. We report a series of five cases of OOM managed in a tertiary care centre in North India. This series underscores the critical need for heightened awareness among dental practitioners about this entity, and highlights the importance of adhering to strict aseptic precautions.
{"title":"Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India","authors":"Sandeep Rao Kordcal , Ishan Gupta , Kanika Chaudhary , Md Tariq Maula , Rahul Yadav , Gagandeep Singh , Manish Soneja , Immaculata Xess","doi":"10.1016/j.mmcr.2025.100730","DOIUrl":"10.1016/j.mmcr.2025.100730","url":null,"abstract":"<div><div>Mucormycosis is an angio-invasive, opportunistic fungal infection, which usually affects individuals with poorly controlled diabetes mellitus. While rhino-orbital-cerebral mucormycosis (ROCM) has been described in the English language literature, odontogenic-onset mucormycosis (OOM) is an emerging clinical entity, which is characterized by a unique port of entry, a distinct mode of onset and clinic-radiological features. We report a series of five cases of OOM managed in a tertiary care centre in North India. This series underscores the critical need for heightened awareness among dental practitioners about this entity, and highlights the importance of adhering to strict aseptic precautions.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100730"},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-11DOI: 10.1016/j.mmcr.2025.100732
Anuja George , Rosmi Jose , Chithra Valsan , Jayanthi Savio , Priyadarshini A. Padaki , Ramesh Kumar
Schizophyllum species are emerging human respiratory pathogens. We report India's likely first case of invasive fungal rhinosinusitis by Schizophyllum radiatum. A 32-year-old healthy woman presented with bilateral nasal discharge. Microscopic examination of the sinus aspirate showed septate hyaline hyphae and culture yielded fungal growth with sterile hyphae. The isolate was identified as S. radiatum by sequencing of the ITS region. This highlights the importance of genomic sequencing for the identification of non-sporulating molds.
{"title":"Schizophyllum radiatum: An uncommon culprit of invasive fungal rhinosinusitis in an immunocompetent patient – A case report from India","authors":"Anuja George , Rosmi Jose , Chithra Valsan , Jayanthi Savio , Priyadarshini A. Padaki , Ramesh Kumar","doi":"10.1016/j.mmcr.2025.100732","DOIUrl":"10.1016/j.mmcr.2025.100732","url":null,"abstract":"<div><div><em>Schizophyllum</em> species are emerging human respiratory pathogens. We report India's likely first case of invasive fungal rhinosinusitis by <em>Schizophyllum radiatum.</em> A 32-year-old healthy woman presented with bilateral nasal discharge. Microscopic examination of the sinus aspirate showed septate hyaline hyphae and culture yielded fungal growth with sterile hyphae. The isolate was identified as <em>S. radiatum</em> by sequencing of the ITS region. This highlights the importance of genomic sequencing for the identification of non-sporulating molds.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100732"},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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