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Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand 由印朵毛癣菌引起的耐药皮肤真菌病的出现:泰国首例病例系列
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-06-01 DOI: 10.1016/j.mmcr.2025.100713
Sutsarun Prunglumpoo , Kunyanut Krongboon , Klaichan intarachaieua , Anzawa Kazushi , Thareena Bunnag , Wattamon Paunrat , Wanchanida komkhong
We identified 5 Thai patients diagnosed with Trichophyton indotineae infection after screening of patients with culture results consistent with Trichophyton mentagrophytes complex who had negative urease test and confirmed by molecular analysis in DNA sequencing at the internal transcribed spacer region, including abnormalities in the Squalene epoxidase gene in 2 patients, which confirmed the spread of terbinafine resistant dermatophytosis in Thailand.
我们在筛选培养结果与毛癣菌脲酶试验阴性的患者后,鉴定出5例被诊断为印度毛癣菌感染的泰国患者,并在DNA内转录间隔区测序进行分子分析证实,其中2例患者角鲨烯环氧化酶基因异常,证实了特比萘芬耐药皮肤真菌病在泰国的传播。
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引用次数: 0
Fungal sepsis in a 7-month-old female: diagnosis through peripheral blood smear 7月龄女性真菌性败血症:通过外周血涂片诊断
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-05-22 DOI: 10.1016/j.mmcr.2025.100708
Yihun Bedaso , Tadesse Alemayehu , Amanuel Anegagregn Bizuneh , Dereje Zeleke Haile , Seble Seifu Zeleke , Mekdes Shifeta , Agete Tadewos Hirigo
We report a case of a 7-month-old female with prolonged high-grade fever unresponsive to broad-spectrum antibiotics and antimalarial drugs. Despite negative cultures and imaging, a Giemsa-stained peripheral blood smear on day 28 revealed yeast cells, suggesting fungal sepsis in the context of prolonged antibiotic exposure and thrombocytopenia. The patient responded well to oral fluconazole, with full clinical recovery. This case underscores the value of peripheral blood smear examination in diagnosing yeast infections in resource-limited settings.
我们报告一例7个月大的女性长时间高热对广谱抗生素和抗疟疾药物无反应。尽管阴性培养和成像,第28天的吉姆萨染色外周血涂片显示酵母细胞,提示真菌败血症在长期抗生素暴露和血小板减少的背景下。患者口服氟康唑反应良好,临床完全恢复。本病例强调了外周血涂片检查在资源有限的情况下诊断酵母菌感染的价值。
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引用次数: 0
Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients 2例免疫功能低下患者由罗梅草引起广泛复发性感染
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-05-08 DOI: 10.1016/j.mmcr.2025.100706
Lotte Keikes , Marit S. van Sandwijk , Evert-Jan Kooi , Marieke Gittelbauer , Karin van Dijk
Medicopsis romeroi, a rare brown-pigmented mold, is one of the causes of phaeohyphomycosis, a (sub)cutaneous or soft tissue fungal infection with formation of nodules, cysts or abscesses. Mainly immunocompromised patients are affected, who may experience a wider spectrum of disease with involvement of other tissues, such as the bones or the sinuses. No specific treatment recommendations are available, but surgical excision appears to be the mainstay of treatment, combined with (long-term) antifungal therapy. In this case series, we describe two immunocompromised patients with extensive and persistent skin lesions caused by M. romeroi, and clinical practice recommendations for optimal treatment.
Medicopsis romeroi是一种罕见的棕色霉菌,是一种皮肤或软组织真菌感染,形成结节、囊肿或脓肿的病原菌之一。受影响的主要是免疫功能低下的患者,他们可能会出现更广泛的疾病,并累及其他组织,如骨骼或鼻窦。没有具体的治疗建议,但手术切除似乎是主要的治疗方法,并结合(长期)抗真菌治疗。在这个病例系列中,我们描述了两名免疫功能低下的患者,他们患有由罗梅罗氏分枝杆菌引起的广泛和持续的皮肤病变,并提出了最佳治疗的临床实践建议。
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引用次数: 0
Invasive tracheal mucormycosis complicated by myiasis following tracheostomy in a diabetic patient: A case report 糖尿病气管切开术后浸润性气管毛霉病并发蝇蛆病1例
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-05-08 DOI: 10.1016/j.mmcr.2025.100707
Yuanjiang Zheng , Li Yang , Jianglin Yu , Shanyu Wang , Xianwei Ye
Invasive tracheal mucormycosis is a rare but fatal opportunistic infection, particularly common in immunocompromised patients. This case report describes a 23-year-old female diabetic patient who developed invasive tracheal mucormycosis following a tracheostomy. The mucormycosis infection was brought under control after antifungal therapy and surgical debridement; however, due to multiple contributing factors, the patient subsequently developed myiasis. This case highlights the importance of early diagnosis, aggressive treatment, and proper tracheostomy management in preventing severe complications.
侵袭性气管毛霉菌病是一种罕见但致命的机会性感染,尤其常见于免疫功能低下的患者。本病例报告描述了一位23岁的女性糖尿病患者,她在气管切开术后发生了侵袭性气管毛霉菌病。经抗真菌治疗和手术清创后,毛霉菌感染得到控制;然而,由于多种因素,患者随后发展为蝇蛆病。这个病例强调了早期诊断、积极治疗和适当的气管切开术管理对预防严重并发症的重要性。
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引用次数: 0
Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report 成功管理的增殖性门孢子虫感染性关节炎和骨髓炎在免疫能力的儿童:一个案例报告
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-04-25 DOI: 10.1016/j.mmcr.2025.100704
Niall Johnston , Bradley Rockliff , Robert Duguid , Pamela Palasanthiran , Adam W. Bartlett , Phoebe CM. Willams , Brendan J. McMullan
Available online We report a case of limb-threatening Lomentospora prolificans elbow infection in a 3-year-old immunocompetent boy following a closed fracture. Resolution of infection was achieved following combined aggressive debridement, combined antifungal therapy, voriconazole-loaded bone cement, and antiseptic joint irrigation. This highlights the need for early diagnosis and multi-modal surgical, medical and other novel adjunctive therapies in managing these difficult-to-treat infections. Increased research and improved access to novel antifungal drugs are essential to enhance treatment options for intrinsically multidrug-resistant fungal infections.
我们报告一例危及肢体的增殖性Lomentospora肘感染在一个3岁的免疫功能正常的男孩后闭合性骨折。通过联合积极清创、联合抗真菌治疗、伏立康唑骨水泥和消毒关节冲洗,感染得以解决。这突出了早期诊断和多模式手术、医疗和其他新型辅助治疗来管理这些难以治疗的感染的必要性。加强研究和改善新型抗真菌药物的可及性对于加强对多重耐药真菌感染的治疗选择至关重要。
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引用次数: 0
Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review 隐球菌性眼内炎合并恶性肿瘤1例报告并文献复习
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-04-23 DOI: 10.1016/j.mmcr.2025.100703
Kamonchanok Phaopraphat, Rujipas Sirijatuphat
Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed Cryptococcus neoformans in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.
隐球菌性眼内炎是一种罕见的隐球菌感染的表现,通常发生在免疫功能低下的患者。在这个病例报告中,我们报告了一位50岁的晚期肺癌女性,伴有多发转移,表现为视力模糊10天。诊断性玻璃体切除发现玻璃体内有新型隐球菌。患者全身性给予两性霉素B和氟胞嘧啶治疗,随后给予氟康唑巩固和维持,同时玻璃体内注射两性霉素B和伏立康唑。经过10个月的治疗,她的视力从2英尺数到3/60,针孔矫正到6/18。
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引用次数: 0
The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients 揭露真相的心脏:原位心脏移植受者中供体来源的侵袭性真菌感染
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-03-31 DOI: 10.1016/j.mmcr.2025.100702
Jay Krishnan, Manuela Carugati, Rachel A. Miller, Cameron R. Wolfe, John R. Perfect, Julia A. Messina
Donor-derived invasive fungal infections among solid organ transplant recipients are rare but sometimes devastating events associated with notable morbidity and mortality. Here we describe two donor-derived fungal infections – one Candida parapsilosis complex infection and one Aspergillus fumigatus infection – that occurred among heart transplant recipients at a quaternary care center. Both recipients survived their infections, though with substantial morbidity despite aggressive surgical intervention and antifungal therapy.
在实体器官移植受者中,供体来源的侵袭性真菌感染是罕见的,但有时是毁灭性的事件,与显著的发病率和死亡率相关。在这里,我们描述了两个供体来源的真菌感染-一个假丝酵母菌复合感染和一个烟曲霉感染-发生在心脏移植受者在第四护理中心。两名受者都存活了下来,尽管有大量的发病率,尽管积极的手术干预和抗真菌治疗。
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引用次数: 0
A fatal case of pulmonary cryptococcosis in an apparently immunocompetent patient from Cote D′ Ivoire 肺隐球菌病的致命病例在一个明显免疫正常的病人从科特迪瓦
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-03-21 DOI: 10.1016/j.mmcr.2025.100701
Ahou Sandrine Konan , Kalou Dibert Zika , Affoué Sandrine Josette Kouakou , Appi Sandrine Kouamé , Malick Senanminfoun Soro , Koffi Daho Adoubryn
Cryptococcosis is an opportunistic mycosis caused by Cryptococcus, mainly affecting the immunocompromised. We report a case of pulmonary cryptococcosis within a 31-year-old immunocompetent patient admitted for painful chest swelling evolving for 4 months prior to admission. The chest X-Ray showed a rounded pulmonary opacity. The chest ultrasound revealed a pulmonary abscess diffusing under the skin. Direct examination using the Indian ink and the May-Grunwald Giemsa staining revealed encapsulated yeasts in the pus. The Culture of the pus on the Sabouraud medium with chloramphenicol confirmed the presence of Cryptococcus neoformans. Cryptococcal antigen was positive. This case reminds us that cryptococcosis should be considered even without immunosuppression.
隐球菌病是一种由隐球菌引起的机会性真菌病,主要影响免疫功能低下者。我们报告一例肺隐球菌病在一个31岁的免疫功能正常的病人入院前4个月的胸痛发展。胸部x线显示圆形肺影。胸部超声显示皮下有一个弥漫性肺脓肿。用印度墨水和梅-格伦沃尔德吉姆萨染色法直接检查发现脓液中有包封的酵母。脓液在含氯霉素的Sabouraud培养基上培养证实了新生隐球菌的存在。隐球菌抗原阳性。本病例提醒我们,即使没有免疫抑制,也应考虑隐球菌病。
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引用次数: 0
The diagnostic role of elevated serum cryptococcal antigen titers in patients with suspected cryptococcal meningitis when lumbar puncture is contraindicated: A case report 腰椎穿刺时血清隐球菌抗原滴度升高对疑似隐球菌性脑膜炎的诊断作用:1例报告
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-03-18 DOI: 10.1016/j.mmcr.2025.100700
Asmus Tukundane, Richard Kwizera, Lillian Tugume, Jayne Ellis, David R. Boulware, David B. Meya
Cryptococcal meningitis is one of the major causes of death in sub-Saharan Africa among individuals with advanced HIV, and it is typically diagnosed through lumbar puncture (LP). However, LP may be contraindicated in some cases, causing a clinical dilemma and potential delay in treatment. We present the case of a 60-year-old female, newly diagnosed with HIV, who presented with a reduced level of consciousness and a positive serum cryptococcal antigen (CrAg) test (high titer = 1:320). Computerized tomographic (CT) brain imaging showed multiple nodular lesions, peri-lesional edema and a midline shift. Despite the contraindication for LP, a low volume lumbar puncture (1–2 mL) was performed in view of the elevated serum CrAg titers and patient's clinical symptoms, in order to rule in a definitive diagnosis of cryptococcal meningitis or exclude tuberculous meningitis. The patient was treated for cryptococcal meningitis and responded well. In patients with a positive serum CrAg test and contraindications to LP, an elevated titer (>1:160) and neurological symptoms may guide the initiation of definitive treatment for cryptococcal meningitis, however further evaluation is needed.
隐球菌脑膜炎是撒哈拉以南非洲晚期艾滋病毒感染者死亡的主要原因之一,通常通过腰椎穿刺(LP)诊断。然而,LP在某些情况下可能是禁忌,导致临床困境和潜在的治疗延误。我们报告一例60岁女性,新诊断为HIV,表现为意识水平降低,血清隐球菌抗原(CrAg)检测阳性(高滴度= 1:20 20)。计算机断层扫描(CT)显示多发结节性病变,病灶周围水肿和中线移位。尽管LP有禁忌症,但考虑到血清CrAg滴度升高和患者的临床症状,为了明确诊断隐球菌性脑膜炎或排除结核性脑膜炎,我们进行了低容量腰椎穿刺(1-2 mL)。患者接受隐球菌性脑膜炎治疗,反应良好。在血清CrAg试验阳性和LP禁忌症的患者中,滴度升高(1:160)和神经系统症状可能指导隐球菌性脑膜炎开始最终治疗,但需要进一步评估。
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引用次数: 0
Fungal peritonitis in a patient on peritoneal dialysis caused by Hyphopichia burtonii: A rare pathogen in human infection 一例腹膜透析患者的真菌性腹膜炎是由一种罕见的人类感染病原体——伯顿丝酵菌引起的
IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2025-03-07 DOI: 10.1016/j.mmcr.2025.100699
Estacio Mayra , Reino Alberto , Rodelo Joaquin , Ustariz Jose
Fungal peritonitis in peritoneal dialysis (PD) patients is rare but is associated with high morbidity and mortality. Candida species are the most common causative agents, but infections caused by unusual, often “nonpathogenic,” fungi are being increasingly reported. Hyphopichia burtonii is typically associated with food spoilage and has rarely been reported in human infections.
We describe the case of a 44-year-old female with end-stage renal disease on continuous ambulatory peritoneal dialysis (CAPD) who developed peritonitis caused by Hyphopichia burtonii. Following the identification of the fungus, the patient was put on hemodialysis, the peritoneal dialysis catheter was removed, and he was given fluconazole for two weeks having favorable clinical development.
2012 Elsevier Ltd. All rights reserved.
腹膜透析(PD)患者的真菌性腹膜炎很少见,但发病率和死亡率却很高。念珠菌是最常见的致病菌,但由不常见的、通常是 "非致病性 "真菌引起的感染报告也越来越多。我们描述了一例 44 岁女性患者的病例,该患者患有终末期肾病,正在进行连续不卧床腹膜透析(CAPD),她患上了由布顿嗜毛孢子菌(Hyphopichia burtonii)引起的腹膜炎。在确定真菌后,患者接受了血液透析,拔除了腹膜透析导管,并服用氟康唑两周,取得了良好的临床效果。2012 Elsevier Ltd. 版权所有。
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引用次数: 0
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Medical Mycology Case Reports
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