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Therapeutic Dilemmas Faced When Managing a Life-Threatening Presentation of a Myocardial Bridge 处理危及生命的心肌桥时面临的治疗困境
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-11 DOI: 10.1155/2022/8148241
D. Falconer, Sariha Yousfani, A. Herrey, P. Lambiase, G. Captur
Background. Myocardial bridges are congenital abnormalities, where a segment of coronary artery travels intramyocardially, rather than the typical epicardial course. The overlying muscle segment is termed “the bridge”. Most myocardial bridges are asymptomatic, but some can result in myocardial ischaemia, arrhythmias, and sudden cardiac death. Case Presentation. A 31-year-old male with no past medical history presented to our tertiary cardiac centre following an out-of-hospital ventricular fibrillation arrest. Coronary angiography and computed tomography of the coronary arteries revealed a 2 cm myocardial bridge overlying the left anterior descending (LAD) artery. An exercise echocardiogram demonstrated severe apical ballooning and hypokinesis during peak exercise, with corresponding ST-segment elevation, resolving on rest. Options for medical therapy of a symptomatic myocardial bridge include beta blockers, calcium channel blockers, ivabradine, or a combination thereof. Surgical interventions include deroofing the bridge and revascularisation of the affected region with bypass grafting. However, a lack of trial data comparing medical regimens and surgical interventions makes it difficult to ascertain the most effective management strategy for each patient. There was disagreement between experts at different tertiary centres over the optimal management of this patient. He was treated with multiple regimes of medical therapy with ongoing ischaemia on stress testing, before undergoing a negative stress test on amlodipine, diltiazem, and isosorbide mononitrate. It was felt that no further intervention was necessary at this time given his exercise test was now negative for ischaemia. However, after seeking a second opinion, he underwent surgical intervention with bypass grafting of his left anterior descending artery, followed by implantation of an implantable cardiac defibrillator. Subsequently, an angiogram postsurgery demonstrated concomitant spasm of the LAD and he was resumed on medical therapy with calcium channel blockers and nitrates. Discussion. Without randomised trials, it is impossible to determine the optimal management strategy for each patient. It is possible that some patients with myocardial bridges are not being trialled on optimal medical therapy prior to undergoing invasive and irreversible interventions.
背景。心肌桥是先天性异常,其中一段冠状动脉在心内行进,而不是典型的心外膜路线。上面的肌肉节称为“桥”。大多数心肌桥是无症状的,但有些可导致心肌缺血、心律失常和心源性猝死。案例演示。一位31岁男性,无既往病史,因院外心室纤颤停搏来到我们的三级心脏中心。冠状动脉造影和计算机断层扫描显示左前降支(LAD)上有一个2厘米的心肌桥。运动超声心动图显示运动高峰时严重的根尖肿胀和运动不足,相应的st段抬高,休息后消退。症状性心肌桥的药物治疗选择包括-受体阻滞剂、钙通道阻滞剂、伊伐布雷定或其组合。手术干预包括拆除桥和搭桥移植术重建受影响的区域。然而,由于缺乏比较医疗方案和手术干预的试验数据,很难确定对每位患者最有效的管理策略。不同三级中心的专家对该患者的最佳管理存在分歧。在接受氨氯地平、地尔硫卓和单硝酸异山梨酯的阴性应激试验之前,他接受了多种药物治疗方案,并进行了持续的缺血应激试验。鉴于他的运动测试结果为缺血阴性,医生认为此时无需进一步干预。然而,在寻求第二意见后,他接受了左前降支搭桥术的手术干预,随后植入了植入式心脏除颤器。随后,术后血管造影显示LAD伴有痉挛,他恢复了钙通道阻滞剂和硝酸盐的药物治疗。讨论。没有随机试验,就不可能确定每个患者的最佳管理策略。有可能一些心肌桥患者在接受侵入性和不可逆干预之前没有接受最佳药物治疗的试验。
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引用次数: 2
A Case Series of Diverse Cardiac Abnormalities in Collegiate Athlete with COVID-19: Role for Multimodality Imaging 新型冠状病毒肺炎大学运动员多种心脏异常病例系列:多模态成像的作用
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-08 DOI: 10.1155/2022/3259978
Vanessa-Rose G Turpin, Kyle Goerl, C. Chow, C. Ade
Introduction Since the COVID-19 pandemic there is concern for subclinical cardiac pathology in the absence of clinical symptoms in collegiate athletes, we present 4 cases of abnormal left ventricular global longitudinal strain (LVGLS), a “red-flag” for potential COVID-19 myocardial disease, following diagnosis with diverse abnormalities reported via multimodality imaging weeks into recovery. Methods Cardiac imaging studies consisting of transthoracic echocardiography (TTE) and cardiovascular magnetic resonance imaging (CMR) were performed 10 days post-COVID-19 diagnosis and several weeks into recovery. Results Initial TTE revealed abnormal left ventricular global longitudinal strain (LVGLS), an identified “red-flag” for potential COVID-19 myocardial disease. Further CMR imaging revealed potential recent/prior myocarditis in 1 athlete. Follow-up TTE several weeks later revealed a return to normal LVGLS. Conversely, 2 cases with normal CMR imaging had a LVGLS that remained abnormal >30 days into recovery. Conclusions These individual cases highlight the substantial differences in echocardiographic and CMR abnormalities between athletes with confirmed COVID-19.
引言自新冠肺炎大流行以来,在大学运动员中缺乏临床症状的情况下,人们担心亚临床心脏病理学,我们报告了4例异常左心室整体纵向应变(LVGLS)病例,这是潜在新冠肺炎心肌疾病的“红滞后”,在康复数周后通过多模态成像报告了各种异常。方法在COVID-19诊断后10天和康复后几周进行心脏成像研究,包括经胸超声心动图(TTE)和心血管磁共振成像(CMR)。结果初次经胸超声心动图显示左心室整体纵向应变(LVGLS)异常,这是潜在新冠肺炎心肌疾病的“红滞后”。进一步的CMR成像显示1名运动员有潜在的近期/既往心肌炎。随访数周后经胸超声心动图显示LVGLS恢复正常。相反,2例CMR成像正常的患者LVGLS在恢复后>30天仍然异常。结论这些病例突出了确诊新冠肺炎运动员超声心动图和CMR异常的显著差异。
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引用次数: 1
Successful Treatment of Severe Paravalvular Leak by Repositioning a Self-Expandable Percutaneous Aortic Valve Bioprosthesis (Evolut PRO+) Using the “Double Snare” Technique 应用“双圈套”技术重新定位自膨胀经皮主动脉瓣生物假体(Evolut PRO+)成功治疗严重瓣旁漏
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-05 DOI: 10.1155/2022/4458109
D. González-Bravo, P. Colon-Hernandez, Melanie Quintana-Serrano, S. Alegre-Boschetti, Juan I Vazquez-Fuster, José J. Acevedo-Valles, Eric Avilés-Rivera
Significant (moderate or severe) paravalvular leak (PVL) after transcatheter aortic valve replacement (TAVR) remains a common phenomenon and has been associated with decrease survival and quality of life. Transcatheter valve embolization and migration (TVEM) is a rare post-TAVR complication that can occur in 1% of cases and has been associated with worse patient outcomes. Valve embolization or migration into the left ventricle can result in significant PVL causing hemodynamic instability, shock, heart failure, and hemolytic anemia. Although this complication most commonly occurs in the acute setting (90%) within 4 hours of TAVR, it can also present late (4 hr-43 days later) in 10% of cases. There are no clear guidelines as to how this condition should be managed; however, several percutaneous bailout techniques exist that can ultimately spare the patient from emergent cardiovascular surgery. We present a rare case of late ventricular transcatheter aortic valve migration 3 days after TAVR causing severe PVL and heart failure symptoms that was successfully treated using the percutaneous “double snare” technique.
经导管主动脉瓣置换术(TAVR)后出现明显(中度或重度)瓣旁渗漏(PVL)仍然是一种常见现象,并与生存率和生活质量下降有关。经导管瓣膜栓塞和移位(TVEM)是一种罕见的TAVR后并发症,可发生在1%的病例中,并与更糟糕的患者结局有关。瓣膜栓塞或迁移到左心室可导致显著的PVL,导致血液动力学不稳定、休克、心力衰竭和溶血性贫血。尽管这种并发症最常见于TAVR后4小时内的急性发作(90%),但也可能出现较晚(4 hr-43天后)。对于如何管理这种情况,没有明确的指导方针;然而,有几种经皮抢救技术可以最终使患者免于紧急心血管手术。我们报告了一例罕见的TAVR后3天心室经导管主动脉瓣晚期移位的病例,该病例导致严重的PVL和心力衰竭症状,并使用经皮“双圈套器”技术成功治疗。
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引用次数: 1
Complete AV Block in Vaccinated COVID-19 Patient 接种新冠肺炎疫苗的患者完全AV阻断
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-30 DOI: 10.1155/2022/9371818
Kevin Lee, O. Rahimi, N. Gupta, C. Ahsan
Background. Coronavirus 2019 (COVID-19) was initially identified approximately in December 2019 at Wuhan, China, as patients presented with vague prodromal and respiratory symptoms. With the developing investigation of its clinical manifestation, cardiac symptoms have been widely reported including acute coronary syndromes, myocarditis, arrhythmias, heart failure, and cardiac arrest. Case Summary. An 84 year-old male with history of coronary artery disease, hypertension, and hyperlipidemia presented to an outside urgent care with prodromal symptoms. The patient had received the second Pfizer vaccine three months prior. This presentation, he was found to be COVID-19 positive as well as bradycardic with a complete AV block. He was transferred to a tertiary center for further evaluation and management. However, after transfer, the patient refused further invasive cardiac interventions and after medical therapy was discharged home in complete AV block. Discussion. We report a novel case of a Pfizer-vaccinated patient whose initial presenting symptoms of COVID-19 included a complete AV block as well as the challenges and difficulties in approaching such patients. Although this patient's etiology of his complete AV block may result from multiple factors, given the acuity in setting of concurrent COVID-19 infections, top differentials include viral myocarditis, COVID-19-induced Takotsubo cardiomyopathy complicated by a complete AV-block, or a direct conduction pathway infection. Management of patients should focus on a multidisciplinary approach, and prevention is critical via vaccination.
背景。冠状病毒2019 (COVID-19)最初大约于2019年12月在中国武汉被发现,当时患者表现出模糊的前体症状和呼吸道症状。随着对其临床表现的深入研究,心脏症状已被广泛报道,包括急性冠状动脉综合征、心肌炎、心律失常、心力衰竭和心脏骤停。案例总结。84岁男性,有冠状动脉疾病、高血压和高脂血症病史。该患者在三个月前接受了第二种辉瑞疫苗。在这次报告中,他被发现为COVID-19阳性,心动过缓,伴有完全的房室传导阻滞。他被转移到三级中心进行进一步的评估和管理。然而,在转院后,患者拒绝进一步的有创心脏介入治疗,并在接受药物治疗后出院,房颤完全阻断。讨论。我们报告了一例辉瑞疫苗接种患者的新病例,其初始表现的COVID-19症状包括完全AV阻断,以及接近此类患者的挑战和困难。虽然该患者完全性房室传导阻滞的病因可能由多种因素导致,但考虑到并发COVID-19感染的急性程度,主要的差异包括病毒性心肌炎、COVID-19诱导的Takotsubo心肌病合并完全性房室传导阻滞或直接传导途径感染。患者管理应注重多学科方法,通过接种疫苗进行预防至关重要。
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引用次数: 4
Rivaroxaban as Therapy for Saphenous Venous Graft Failure due to Venous Outflow Mismatch 利伐沙班治疗因静脉流出不匹配引起的Saphenous Venus移植物失败
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-16 DOI: 10.1155/2022/9729989
Matthew T Lee, Ayush Mohan, Jenna E Lee, Daniel T. Lee
Background Recurrent angina and long-term occlusion following coronary artery bypass graft surgery is often treated with percutaneous coronary intervention, a high-risk intervention for distal embolization. Here, we present the utilization of the novel oral anticoagulant, rivaroxaban, in the treatment of saphenous vein graft thrombosis with complete resolution of the thrombus secondary to graft outflow mismatch. Case Presentation. A 69-year-old man with triple coronary artery bypass grafting using a saphenous vein and left internal mammary artery, performed in 2017, presented at our hospital for recurrent angina. Coronary angiography revealed a patent LIMA to LAD and a large clot burden in the venous conduit to the first OM/terminal circumflex—theorized to be due to an outflow mismatch of the large saphenous vein to the native artery resulting in stasis. Instead of percutaneous coronary intervention, he was treated with rivaroxaban 20 mg once a day. The angiography 4 weeks after starting rivaroxaban showed complete resolution of the thrombus. Conclusion Rivaroxaban could become a potential treatment option in thrombus reversal due to static venous flow with subsequent long-term patency of the graft. Additionally, its use may be indicated in the generalized prevention of VGF.
背景冠状动脉搭桥术后复发性心绞痛和长期闭塞通常采用经皮冠状动脉介入治疗,这是一种远端栓塞的高危干预措施。在此,我们介绍了新型口服抗凝剂利伐沙班在治疗隐静脉移植物血栓形成中的应用,并完全消除了移植物流出不匹配引起的血栓。案例介绍。2017年,一名69岁的男性因复发性心绞痛在我院接受了隐静脉和左乳内动脉三重冠状动脉搭桥术。冠状动脉血管造影术显示左前降支有一个未闭的LIMA,第一个OM/回旋支末端的静脉导管中有大量凝块负担,理论上是由于大隐静脉与天然动脉的流出不匹配导致淤滞。他没有接受经皮冠状动脉介入治疗,而是接受了利伐沙班20 mg,每天一次。开始使用利伐沙班4周后的血管造影术显示血栓完全消退。结论利伐沙班可能成为一种潜在的治疗方案,用于治疗因静静脉流动而导致的血栓逆转,并随后使移植物长期通畅。此外,它的用途可以在VGF的一般预防中说明。
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引用次数: 0
Multimodality Imaging for the Evaluation of an Undifferentiated Pleomorphic Sarcoma Presenting as Cardioembolic Stroke 多模态成像对以心栓塞性卒中为表现的未分化多形性肉瘤的评价
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-15 DOI: 10.1155/2022/2749303
R. O. Escárcega, D. Bailey, M. Defrain
Background Cancer and ischemic stroke are associated with significant morbidity and mortality. Hypercoagulability, disseminated intravascular coagulation, venous-to-arterial embolism, and non-bacterial thrombotic endocarditis are among recognized mechanisms. Emboli to the brain, or to other organs, are known to occur as a consequence of liberated thrombotic debris originating from the thrombogenic surface of intracardiac neoplastic entities. The most common primary malignancy of the heart is sarcoma; however, masses that occur in the heart are 20 to 40 times more likely as a consequence of metastasis from other sites. Case Report. A 67-year-old woman presented to the emergency room with two brief episodes of dizziness and diplopia for 2 minutes. She had a medical history of provoked upper extremity DVT after a fracture, hypothyroidism, hyperlipidemia, and soft tissue sarcoma. The sarcoma was initially diagnosed in, and subsequently resected from, the right triceps muscle. During posttreatment surveillance, a second lesion was discovered in the left upper pulmonary lobe, and this was also completely resected 9 months following initial diagnosis. We present a case of a woman with a tertiary (cardiac) site sarcoma that presented with embolic stroke. Conclusion Our case highlights the benefits of multimodality imaging, heart-team approach with oncology support to define anatomy, thereby enable surgical treatment, of a complex intracardiac lesion.
背景癌症和缺血性中风与显著的发病率和死亡率相关。高凝性、弥散性血管内凝血、静脉至动脉栓塞和非细菌性血栓性心内膜炎是公认的机制。众所周知,脑或其他器官的栓塞是由心内肿瘤实体的血栓形成表面释放的血栓碎片引起的。最常见的原发性心脏恶性肿瘤是肉瘤;然而,由于其他部位的转移,发生在心脏的肿块的可能性要高出20到40倍。病例报告。一名67岁的妇女因两次短暂的头晕和复视症状进入急诊室,持续2分钟。她有骨折、甲状腺功能减退、高脂血症和软组织肉瘤后引发的上肢DVT病史。肉瘤最初诊断于右三头肌,随后切除。在治疗后监测期间,在左上肺叶发现了第二个病变,在最初诊断后9个月,该病变也被完全切除。我们报告了一例女性第三(心脏)部位肉瘤,并伴有栓塞性中风。结论我们的病例强调了多模态成像、心脏团队方法和肿瘤学支持的优势,以确定复杂心内病变的解剖结构,从而实现手术治疗。
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引用次数: 0
Profound Vagal Tone and Bradycardia Mimicking Asystole: A Resuscitation Case Report 深迷走神经音与心动过缓模拟性心搏停止:一例复苏病例报告
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-08 DOI: 10.1155/2022/4759950
J. Mannion, L. Chapman, K. Deasy, N. Colwell
A 48-year-old man presented with dizziness. When he arrived at the emergency department, he collapsed and became pulseless. Prior to his collapse, he was asymptomatic and now even participated in multiple marathon and ultra-running events per year. However, he previously experienced a vasospastic inferior STEMI eight years prior from cocaine use. As a result, he had an ischaemic cardiomyopathy with LVEF of 45%. He never took any further illicit substances after the STEMI; instead, he changed his lifestyle completely and commenced extreme endurance sports. After one hour of alternations between VF/VT rhythms and asystole, a rhythm check demonstrated a single complex with a corresponding pulse. He had received 12 mg of epinephrine up to that point as per local resuscitation guidelines. Upon diagnosing extreme bradycardia, 2 mg of total atropine administration resulted in ROSC. We theorise that this bradycardia was a result of increased vagal tone as ROSC was quickly achieved following atropine administration.
48岁男性,表现为头晕。当他被送到急诊科时,他瘫倒在地,失去了脉搏。在他崩溃之前,他没有任何症状,现在甚至每年参加多次马拉松和超跑比赛。然而,在可卡因使用8年前,他曾经历过血管痉挛性低度STEMI。结果,他患有缺血性心肌病,LVEF为45%。在STEMI之后,他再也没有服用任何非法药物;相反,他完全改变了自己的生活方式,开始了极限耐力运动。在VF/VT节律和无骤停交替一小时后,节律检查显示有一个相应的脉冲复合体。根据当地复苏指南,到那时为止,他已经接受了12毫克的肾上腺素。诊断为极度心动过缓后,总阿托品给药2毫克导致ROSC。我们推测,这种心动过缓是迷走神经张力增加的结果,因为服用阿托品后迅速达到ROSC。
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引用次数: 0
Multiple Coronary Fistulas as a Rare Cause of Stable Angina Pectoris 多发性冠状动脉瘘是稳定型心绞痛的罕见病因
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-04 DOI: 10.1155/2022/9372295
J. Habek, Tea Friščić, J. Šikić, M. Perčić, D. Strinić, Daria Ljubas Perčić
Congenital coronary artery-left ventricular multiple microfistulas (CA-LVMMFs) are rare anomalies in adults. They are more often found in female patients, and they usually originate from the distal segments of the coronary arteries, but they can originate from a proximal segments of a coronary arteries, and these patients are likely to be identified and treated in the pediatric age group. They are mostly asymptomatic. When symptoms and complications occur, they include angina, myocardial infarction, atrial heart failure, arrhythmias, and endocarditis. The management of CA-LVMMFs is controversial, but it is generally agreed that conservative medical management is the primary treatment of choice. Our case describes a rare form of CA-LVMMFs draining into the left ventricle in a female patient presenting with fatigue, atypical anginal symptoms, atrial fibrillation, and premature ventricular complexes, without concomitant obstructive coronary artery disease.
先天性冠状动脉左心室多发性微血管畸形(CA LVMMFs)在成人中是罕见的异常。它们更常见于女性患者,通常起源于冠状动脉的远端,但也可能起源于冠状血管的近端,这些患者很可能在儿科年龄组中被识别和治疗。他们大多没有症状。当出现症状和并发症时,包括心绞痛、心肌梗死、心房心力衰竭、心律失常和心内膜炎。CA LVMMF的管理是有争议的,但人们普遍认为保守的医疗管理是首选的治疗方法。我们的病例描述了一名女性患者出现疲劳、非典型心绞痛症状、心房颤动和室性早搏综合征,并伴有阻塞性冠状动脉疾病的一种罕见形式的CA LVMMF流入左心室。
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引用次数: 1
Rare Case of Cavernous Haemangioma of the Right Atrium with Probable Hepatic Haemangioma 右心房海绵状血管瘤合并肝血管瘤的罕见病例
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-02-27 DOI: 10.1155/2022/9214196
S. Harrison
Cardiac haemangiomas are rare causes of atrial masses. This case report is of a 44-year-old male who presented with a right atrial mass that was found incidentally on a CT performed for renal colic. The mass was further investigated with a transthoracic echocardiogram that showed that it was echodense and arising from the Eustachian valve in the right atrium. Coronary angiogram revealed large well-developed atrial branches that crossed superiorly over the left atrium and entered the mass in the right atrium. Surgical resection was undertaken, and this confirmed that the mass had a fleshy, encapsulated appearance with a sessile stalk. Histology demonstrated a cavernous haemangioma. The patient had a residual small defect in the interatrial septum postoperatively but otherwise made a good recovery.
心脏血管瘤是引起心房肿块的罕见原因。本病例报告是一位44岁男性患者,他在肾绞痛的CT检查中偶然发现了右心房肿块。经胸超声心动图显示肿块回声密集,起源于右心房的咽鼓瓣。冠状动脉造影显示发育良好的大心房分支在左心房上方穿过并进入右心房肿块。手术切除,这证实了肿块有肉质,包被外观与无柄柄。组织学表现为海绵状血管瘤。患者术后房间隔有残留的小缺损,但其他方面恢复良好。
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引用次数: 0
Severe Chest Pain in a Young Patient with Behçet's Disease: A Rare Manifestation 一名年轻Behçet病患者的严重胸痛:罕见表现
IF 0.6 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-02-25 DOI: 10.1155/2022/6032423
Steen Reed, M. McGee, S. Sritharan
A 32-year-old man with a background of Behçet's disease developed severe chest pain. The onset coincided with an episode of sacroiliitis. The patient was diagnosed with pericarditis and was successfully treated with a combination of anti-inflammatory agents. Pericarditis is a rare manifestation of Behçet's disease.
一名32岁的男子患有贝赛特氏病,出现严重胸痛。发病时伴有骶髂关节炎发作。患者被诊断为心包炎,并通过联合抗炎药成功治疗。心包炎是Behçet病的一种罕见表现。
{"title":"Severe Chest Pain in a Young Patient with Behçet's Disease: A Rare Manifestation","authors":"Steen Reed, M. McGee, S. Sritharan","doi":"10.1155/2022/6032423","DOIUrl":"https://doi.org/10.1155/2022/6032423","url":null,"abstract":"A 32-year-old man with a background of Behçet's disease developed severe chest pain. The onset coincided with an episode of sacroiliitis. The patient was diagnosed with pericarditis and was successfully treated with a combination of anti-inflammatory agents. Pericarditis is a rare manifestation of Behçet's disease.","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44721736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Case Reports in Cardiology
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