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Patent landscape and innovation trajectories of mRNA vaccine technologies mRNA疫苗技术的专利格局和创新轨迹
IF 1.9 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-08-04 DOI: 10.1016/j.wpi.2025.102382
Kyungdae Oh , Youngbo Choi , Surin Hong
This study presents a comprehensive patent-based analysis of mRNA vaccine technologies, tracing their progression from experimental tools to scalable biomedical platforms after the COVID-19 pandemic. Leveraging Cooperative Patent Classification (CPC) codes and 25 years of global filings (2001–2025), we built a functional technology tree and mapped innovation across delivery systems, structural design, adjuvants and immune modulation, and Good Manufacturing Practice (GMP)-compliant manufacturing. Lipid nanoparticle-mediated delivery dominates recent applications, underscoring industry priorities in efficacy and scale. Growth curves signal entry into technological maturity, accompanied by wider participation from pharmaceutical firms, academia, and public institutes. Strategic profiling reveals contrasting R&D strategies: ModernaTX and Translate Bio pursue vertically integrated platforms; CureVac emphasizes antigen design and RNA stability; MIT focuses on delivery technologies with broad cross-domain reach. These patterns indicate that mRNA vaccines are becoming foundational infrastructure for precision medicine, oncology, and next-generation immunotherapies. Future competition is poised to intensify around delivery innovation, RNA stabilization, immune modulation, and robust GMP production. Our findings illuminate evolving intellectual-property strategies and highlight platform integration, manufacturing optimization, and cross-sector collaboration as key drivers of innovation in the global mRNA vaccine ecosystem.
本研究对mRNA疫苗技术进行了全面的基于专利的分析,追踪了它们在COVID-19大流行后从实验工具到可扩展的生物医学平台的进展。利用合作专利分类(CPC)代码和25年的全球申请(2001-2025),我们建立了一个功能技术树,并绘制了跨越给药系统、结构设计、佐剂和免疫调节以及符合良好生产规范(GMP)生产的创新图谱。脂质纳米颗粒介导的递送主导了最近的应用,强调了功效和规模的行业优先级。增长曲线标志着进入技术成熟阶段,伴随着制药公司、学术界和公共机构更广泛的参与。战略分析揭示了对比鲜明的研发战略:ModernaTX和Translate Bio追求垂直整合平台;CureVac强调抗原设计和RNA稳定性;麻省理工学院专注于具有广泛跨领域影响的交付技术。这些模式表明mRNA疫苗正在成为精准医学、肿瘤学和下一代免疫疗法的基础设施。未来的竞争将围绕递送创新、RNA稳定、免疫调节和稳健的GMP生产而加剧。我们的研究结果阐明了不断发展的知识产权战略,并强调了平台整合、制造优化和跨部门合作是全球mRNA疫苗生态系统创新的关键驱动因素。
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引用次数: 0
The effective use of artificial intelligence in patent searches: A case study in using AI-based classifiers to identify AI inventions 人工智能在专利检索中的有效应用:使用基于人工智能的分类器识别人工智能发明的案例研究
IF 1.9 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-08-27 DOI: 10.1016/j.wpi.2025.102387
Aleksei L. Kalinichenko, Kelvin W. Willoughby
This study proposes a new patent search methodology for enhancing the quality and utility of patent research. The methodology focuses on techniques for effectively searching large patent datasets using artificial intelligence (AI) based classifiers to generate robust and reproducible results for subsequent statistical analysis. An extensive literature review revealed that salient approaches to patent searching fail to provide transparent, accurate and reproducible results, thereby hindering validation as well as evoking the need for manual post-processing and subjective judgments. Our proposed methodology, to enable precise, reliable and reproducible AI-enabled search queries, involves employing a novel terminological framework and formulating search regulations based on a formal definition of the technological subject matter of interest. We tested the methodology by applying it to patent searches in the field of AI technologies. In other words, we employed AI to facilitate our development of an operational technical definition of AI for patent searches. The primary results of our research are: (1) an automated patent search technique utilizing a learning algorithm guided by a formal definition of the search area; and (2) a novel terminological framework tailored for patent searches in the AI technology domain. Our approach offers enhanced transparency, reproducibility, and reliability in patent research, with applicability to both AI and other fields of technology.
本研究提出了一种新的专利检索方法,以提高专利研究的质量和实用性。该方法侧重于使用基于人工智能(AI)的分类器有效搜索大型专利数据集的技术,以生成鲁棒性和可重复的结果,用于后续的统计分析。一项广泛的文献综述表明,专利检索的主要方法无法提供透明、准确和可重复的结果,从而阻碍了验证,并引发了人工后处理和主观判断的需要。为了实现精确、可靠和可重复的人工智能搜索查询,我们提出的方法包括采用一种新的术语框架,并根据感兴趣的技术主题的正式定义制定搜索规则。我们通过将其应用于人工智能技术领域的专利检索来测试该方法。换句话说,我们利用人工智能来促进我们对专利检索人工智能的操作技术定义的开发。本研究的主要成果有:(1)利用一种以搜索区域的正式定义为指导的学习算法的自动专利检索技术;(2)为人工智能技术领域的专利检索量身定制的新术语框架。我们的方法在专利研究中提供了更高的透明度、可重复性和可靠性,适用于人工智能和其他技术领域。
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引用次数: 0
Evaluating the effectiveness of ranking-based patent search engines for identifying relevant prior art: A comparative study in the area of chemistry 评估基于排名的专利搜索引擎识别相关现有技术的有效性:化学领域的比较研究
IF 2.2 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-06-05 DOI: 10.1016/j.wpi.2025.102358
David Rees, Manuel Wirz
The rapid development of patent search tools, most of which now include a results ranking system as a matter of course, has revolutionized the speed with which relevant prior art documents can be found compared to traditional search techniques. This short study builds upon a substantial body of work which investigates the use of AI and semantic engines in prior art searching and makes use of unambiguous, objective, yes/no criteria in performance assessment and tool comparison.
与传统的检索技术相比,专利检索工具的快速发展已经彻底改变了查找相关现有技术文件的速度,其中大多数工具现在理所当然地包括一个结果排序系统。这个简短的研究建立在大量工作的基础上,这些工作调查了人工智能和语义引擎在现有技术搜索中的使用,并在性能评估和工具比较中使用明确、客观、是/否标准。
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引用次数: 0
Special issue on applications of Generative AI and Large Language Models in the patent domain 专利领域的生成式人工智能和大型语言模型应用特刊
IF 2.2 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-06-24 DOI: 10.1016/j.wpi.2025.102365
Tony Trippe (Associate Editor), Jieh-Sheng Jason Lee (Assistant Professor)
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引用次数: 0
Scalable multi-label patent classification via iterative large language model-assisted active learning 基于迭代大语言模型辅助主动学习的可扩展多标签专利分类
IF 1.9 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.wpi.2025.102380
Songquan Xiong, Shikun Chen, Jianwei He, Yangguang Liu, Junjie Mao, Chao Liu
Patent classification faces increasingly complex challenges due to the exponential growth in volume and technical sophistication of global patent databases. A substantial proportion of patents inherently belong to multiple technological categories simultaneously, rendering classification particularly challenging for both manual and automated systems. Current approaches struggle with computational scalability, prohibitive annotation costs, and the accurate identification of overlapping technical concepts across interdisciplinary innovations. This study presents a novel iterative framework that combines the advanced text comprehension capabilities of Large Language Models (LLMs) with the sample-efficient principles of active learning (AL) for scalable multi-label patent classification. We evaluated our approach using drone-related technologies extracted from a comprehensive dataset of 100,000 patents, focusing on ten key technological component categories. Our LLM-assisted active learning methodology achieved Macro-F1 and Micro-F1 scores of 0.85 and 0.88, respectively, demonstrating a 15% improvement in Macro-F1 compared to established baseline methods. Our approach reduced the required manual annotation effort by approximately 60% while maintaining comparable classification performance. These empirical findings demonstrate the potential for transforming large-scale patent analysis workflows and improving the efficiency of intellectual property management systems
由于全球专利数据库的数量和技术复杂性呈指数级增长,专利分类面临着越来越复杂的挑战。相当大比例的专利本质上同时属于多个技术类别,这使得人工和自动化系统的分类特别具有挑战性。当前的方法与计算可伸缩性、令人望而却步的注释成本以及跨跨学科创新的重叠技术概念的准确识别作斗争。本研究提出了一种新的迭代框架,该框架结合了大型语言模型(llm)的高级文本理解能力和用于可扩展多标签专利分类的主动学习(AL)的样本效率原则。我们使用从10万项专利的综合数据集中提取的无人机相关技术来评估我们的方法,重点关注10个关键技术组件类别。我们的llm辅助主动学习方法的Macro-F1和Micro-F1得分分别为0.85和0.88,与既定的基线方法相比,Macro-F1提高了15%。我们的方法将所需的手动注释工作减少了大约60%,同时保持了相当的分类性能。这些实证研究结果证明了大规模专利分析工作流程的转变和提高知识产权管理系统效率的潜力
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引用次数: 0
Literature listing 文献清单
IF 2.2 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-06-20 DOI: 10.1016/j.wpi.2025.102374
Susan Bates (Independent Researcher)
Welcome to the latest quarterly Literature Listing intended as a current awareness service for readers indicating newly published books, journal, and conference articles on IP management; Information Retrieval Techniques; Patent Landscapes; Education & Certification; and Legal & Intellectual Property Office Matters. The current Literature Listing was compiled mid-May 2025. Key resources include Scopus, Digital Commons, publishers' RSS feeds, and serendipity! This article gives a selection of interesting references to whet your appetite - the full list of references can be found in the companion datafile.
欢迎访问最新的季刊《文献列表》,该列表旨在为读者提供最新的知识产权管理相关书籍、期刊和会议文章的了解服务;信息检索技术;专利景观;教育,认证;和法律&;知识产权局事宜。目前的文献清单是在2025年5月中旬编制的。关键资源包括Scopus、Digital Commons、出版商的RSS订阅和serendipity!本文提供了一些有趣的参考文献来满足您的胃口——完整的参考文献列表可以在附带的数据文件中找到。
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引用次数: 0
Digital marketing of standard essential patent licensing programs 数字营销标准必备专利许可程序
IF 1.9 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-08-16 DOI: 10.1016/j.wpi.2025.102385
Gülfem Özmen , Jussi Heikkilä , Matti Karvonen , Ville Ojanen
We present empirical evidence on the digital marketing choices of standard essential patent licensing programs on patent pool and licensor websites. We highlight the importance of dynamic learning in licensing negotiation events and strategic information revelation in the presence of asymmetric information. We document licensing schemes and licensed units adopted in patent licensing programs. We analyze the marketing strategies of licensing programs using applicable elements of the Marketing Mix framework. We observe significant variation in publicly available information across licensing programs. This suggests that licensors face trade-offs in deciding what information is revealed and anchored in pre-negotiations, as part of licensing program marketing, and during confidential licensing negotiations. Future studies could analyze how generative artificial intelligence (AI) systems may promote marketing and transparency of patent licensing programs.
我们提出了关于专利池和许可方网站上标准必要专利许可程序的数字营销选择的经验证据。我们强调了动态学习在许可谈判事件和存在不对称信息的战略信息披露中的重要性。我们记录了专利许可计划中采用的许可方案和许可单位。我们使用营销组合框架的适用元素来分析许可计划的营销策略。我们观察到不同许可项目的公开信息存在显著差异。这表明许可方在决定在预先谈判中,作为许可计划营销的一部分,以及在保密的许可谈判中披露和固定哪些信息时,面临着权衡。未来的研究可以分析生成式人工智能(AI)系统如何促进专利许可计划的营销和透明度。
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引用次数: 0
A systematic review of artificial intelligence applications and methodological advances in patent analysis 人工智能在专利分析中的应用和方法进展的系统综述
IF 1.9 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-09-01 Epub Date: 2025-08-13 DOI: 10.1016/j.wpi.2025.102383
Tzu-Yu Lin , Li-Chieh Chou

Purpose

This study aims to systematically synthesize the practical applications of artificial intelligence (AI) in patent analysis by constructing a comprehensive matrix that aligns distinct AI techniques with their corresponding analytical tasks. The “AI Technique and Analytical Task” matrix provides a structured framework for understanding how various AI approaches are deployed across different functional objectives within the patent analysis domain.

Design/methodology/approach

This study integrates bibliometric analysis, BERT-based topic modeling, and literature review to explore AI applications in patent analysis. Data were retrieved from the Web of Science Core Collection using a dual-focus search strategy targeting AI techniques and patent analysis tasks. A clear distinction was made to exclude studies analyzing AI trends using patent data, retaining only those applying AI methods to patent analytics. With these strategies, 718 relevant publications were selected as the basis for analysis.

Findings

The results reveal exponential growth in AI-powered patent analysis research since the mid-2010s, with Technological Forecasting and Social Change (TFSC), Scientometrics, and World Patent Information (WPI) identified as the leading publication platforms. Geographical analysis shows that China and South Korea have rapidly increased their research output and institutional engagement, while the U.S. maintains a foundational yet less recent presence.
With topic modeling technique, this study identified eleven major thematic clusters, spanning tasks such as emerging knowledge discovery, technology forecasting, and opportunity identification. These were integrated into “AI Technique and Analytical Task” matrix, which systematically maps the relationships between AI methods (such as pretrained language models, convolutional neural networks, semantic analysis, and topic modeling) and their practical implementations. Among these, patent classification and nature language processing (NLP) emerged as the most impactful applications, underscoring AI's vital role in enabling scalable, data-driven approaches to managing complex patent information.

Originality

This study presents a novel integration of multi-layered literature retrieval strategies, bibliometric analysis, BERT-based topic modeling, and an AI technique-to-analytical task matrix to construct a systematic and structured knowledge framework. This integrative approach not only delineates the interdisciplinary evolution of AI applications in patent analysis but also provides strategic guidance for future research, particularly in advancing empirical validation, informing policy applications, and promoting global inclusivity in this emerging field.
本研究旨在通过构建一个综合矩阵,将不同的人工智能技术与其相应的分析任务结合起来,系统地综合人工智能(AI)在专利分析中的实际应用。“人工智能技术和分析任务”矩阵提供了一个结构化框架,用于理解如何在专利分析领域内跨不同功能目标部署各种人工智能方法。本研究结合文献计量分析、基于bert的主题建模和文献综述,探索人工智能在专利分析中的应用。使用针对人工智能技术和专利分析任务的双焦点搜索策略从Web of Science核心馆藏中检索数据。明确区分了使用专利数据分析人工智能趋势的研究,只保留了那些将人工智能方法应用于专利分析的研究。根据这些策略,选择了718份相关出版物作为分析的基础。结果显示,自2010年代中期以来,人工智能驱动的专利分析研究呈指数级增长,其中技术预测与社会变革(TFSC)、科学计量学(Scientometrics)和世界专利信息(WPI)被确定为领先的出版平台。地理分析表明,中国和韩国的研究产出和机构参与都在迅速增加,而美国则保持着基础地位,但时间并不长。利用主题建模技术,本研究确定了11个主要的主题集群,涵盖了新兴知识发现、技术预测和机会识别等任务。这些被整合到“人工智能技术和分析任务”矩阵中,该矩阵系统地映射了人工智能方法(如预训练语言模型、卷积神经网络、语义分析和主题建模)与其实际实现之间的关系。其中,专利分类和自然语言处理(NLP)成为最具影响力的应用,突显了人工智能在实现可扩展、数据驱动的方法来管理复杂专利信息方面的重要作用。本研究将多层文献检索策略、文献计量分析、基于bert的主题建模和人工智能技术-分析任务矩阵相结合,构建系统化、结构化的知识框架。这种综合方法不仅描述了专利分析中人工智能应用的跨学科演变,而且为未来的研究提供了战略指导,特别是在推进经验验证、为政策应用提供信息和促进这一新兴领域的全球包容性方面。
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引用次数: 0
IF 1.9 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-08-20 DOI: 10.1016/j.wpi.2025.102384
George J.H. Huang
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引用次数: 0
Encoder models at the European Patent Office: Pre-training and use cases 欧洲专利局编码器模型:预训练和用例
IF 2.2 Q2 INFORMATION SCIENCE & LIBRARY SCIENCE Pub Date : 2025-06-01 Epub Date: 2025-04-25 DOI: 10.1016/j.wpi.2025.102360
Volker D. Hähnke, Arnaud Wéry, Matthias Wirth, Alexander Klenner-Bajaja
Patents are organized using systems of technical concepts like the Cooperative Patent Classification. Classification information is extremely valuable for patent professionals, particularly for patent search. Language models have proven useful in Natural Language Processing tasks, including document classification. Generally, pre-training on a domain is essential for optimal downstream performance. Currently, there are no models pre-trained on patents with sequence length above 512. We pre-trained a RoBERTa model with sequence length 1024, increasing the fully covered claims sections from 12% to 53%. It has a ‘base’ configuration, reducing free parameters compared to ‘large’ models in the patent domain three-fold. We fine-tuned the model on classification tasks in the CPC, up to leaf level. Our tokenizer produces sequences on average 5% and up to 10% shorter than the general English RoBERTa tokenizer. With our pre-trained ‘base’ size model, we reach classification performance better than general English models, comparable to ‘large’ models pre-trained on patents. On the finest CPC granularity, 88% of test documents have at least one ground truth symbol in the top 10 predictions. Our CPC prediction models and data sets are publicly accessible. With the described procedures, we can periodically repeat pre-training and fine-tuning to cope with drift effects.
专利是通过技术概念系统(如专利合作分类)组织起来的。分类信息对专利专业人员来说非常宝贵,尤其是在专利检索方面。事实证明,语言模型在自然语言处理任务(包括文档分类)中非常有用。一般来说,对某一领域进行预训练对于优化下游性能至关重要。目前,还没有针对序列长度超过 512 的专利进行预训练的模型。我们对序列长度为 1024 的 RoBERTa 模型进行了预训练,将完全覆盖的权利要求部分从 12% 增加到 53%。该模型采用 "基础 "配置,与专利领域的 "大型 "模型相比,自由参数减少了三倍。我们在 CPC 的分类任务中对模型进行了微调,直至叶级。我们的标记符号生成器生成的序列比一般的英语 RoBERTa 标记符号生成器平均短 5%,最多可短 10%。使用我们预先训练好的 "基本 "大小模型,我们的分类性能比一般英语模型更好,可与预先训练好的专利 "大 "模型相媲美。在最细的 CPC 粒度上,88% 的测试文档在前 10 项预测中至少有一个地面实况符号。我们的 CPC 预测模型和数据集均可公开访问。利用所述程序,我们可以定期重复预训练和微调,以应对漂移效应。
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引用次数: 0
期刊
World Patent Information
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