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Bilateral primary adrenal lymphoma 双侧原发性肾上腺淋巴瘤
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-26 DOI: 10.1002/jgf2.70042
Rio Shimizu MD, Shogo Shirota MD
<p>A previously healthy 83-year-old woman was admitted to our hospital with a three-week history of fever and a one-day history of lower back pain. On physical examination, her body temperature was 38.9°C, blood pressure was 100/61 mmHg, and pulse rate was 112 beats/min. Palpable masses in the bilateral costal areas and bilateral costovertebral angle tenderness to percussion were noted. Laboratory tests revealed an elevated white blood cell count of 10,470/μL, lactate dehydrogenase level of 603 U/L, C-reactive protein of 15.64 mg/dL, and soluble interleukin-2 receptor of 2403 U/mL. Cortisol level was 4.57 μg/dL, and adrenocorticotropic hormone was 549.0 pg/mL. Adrenocorticotropic hormone stimulation test revealed a peak cortisol level of 4.99 μg/dL. Abdominal contrast-enhanced computed tomography (CT) demonstrated bilateral adrenal enlargement with heterogeneous enhancement (Figure 1). The right and left adrenal glands were 7 and 6 cm long, respectively. CT-guided biopsy of the right adrenal mass revealed proliferation of atypical cells with a high nuclear-to-cytoplasmic ratio on hematoxylin and eosin staining. Immunohistochemical staining revealed CD20 and Bcl-6 positivity, consistent with diffuse large B-cell lymphoma (Figure 2A,B). Based on these findings, the patient was diagnosed with bilateral primary adrenal lymphoma and primary adrenal insufficiency. She was treated with hydrocortisone at a dose of 20–30 mg per day, adjusted according to her clinical condition, and subsequently started on chemotherapy with rituximab, cyclophosphamide, doxorubicin, etoposide, and prednisone, but died on the 117th hospital day.</p><p>Primary adrenal lymphoma (PAL) is a rare lymphoma that accounts for approximately 1% of all malignant lymphomas, of which 80% are bilateral.<span><sup>1, 2</sup></span> PAL is characterized by its large size (>5 cm) but lacks specific imaging features distinguishing it from other adrenal malignancies.<span><sup>2, 3</sup></span> Other differential diagnoses of bilateral adrenal masses include pheochromocytoma, tuberculosis, or metastases. The average size of PAL masses has been reported to be 5.5 cm, while other bilateral adrenal masses are generally smaller, often less than 5 cm.<span><sup>4</sup></span> In addition, in cases of bilateral adrenal masses, adrenal insufficiency has been reported in 57% of PAL and 94% of tuberculosis and is less common in pheochromocytoma and metastasis.<span><sup>4</sup></span> If bilateral adrenal masses >5 cm are found in a patient with fever and back pain, it is important to consider PAL, evaluate adrenal function, and perform biopsy promptly.</p><p><b>Rio Shimizu:</b> Writing – original draft; data curation; investigation. <b>Shogo Shirota:</b> Writing – review and editing; conceptualization; supervision; project administration.</p><p>This study did not receive any specific grants from agencies in the public, commercial, or non-profit sectors.</p><p>The authors declare that they have n
一名先前健康的83岁妇女因三周的发热史和一天的腰痛史入住我院。查体体温38.9℃,血压100/61 mmHg,脉搏112次/min。双侧肋区可触及肿块,双侧肋椎角触痛。实验室检查显示白细胞计数升高10,470/μL,乳酸脱氢酶升高603 U/L, c反应蛋白升高15.64 mg/dL,可溶性白介素-2受体升高2403 U/mL。皮质醇4.57 μg/dL,促肾上腺皮质激素549.0 pg/mL。促肾上腺皮质激素刺激试验显示皮质醇峰值为4.99 μg/dL。腹部增强计算机断层扫描(CT)显示双侧肾上腺肿大伴非均匀增强(图1)。右肾上腺长7 cm,左肾上腺长6 cm。ct引导下的右侧肾上腺肿块活检显示苏木精和伊红染色显示核质比高的非典型细胞增生。免疫组化染色显示CD20和Bcl-6阳性,与弥漫性大B细胞淋巴瘤一致(图2A,B)。基于这些发现,患者被诊断为双侧原发性肾上腺淋巴瘤和原发性肾上腺功能不全。患者接受氢化可的松治疗,剂量为20 - 30mg /天,根据其临床情况进行调整,随后开始使用利妥昔单抗、环磷酰胺、阿霉素、依托泊苷和强的松化疗,但在第117天死亡。原发性肾上腺淋巴瘤(PAL)是一种罕见的淋巴瘤,约占所有恶性淋巴瘤的1%,其中80%发生在双侧。1,2 PAL的特点是体积大(约5cm),但缺乏与其他肾上腺恶性肿瘤区分的特异性影像学特征。其他双侧肾上腺肿块的鉴别诊断包括嗜铬细胞瘤、结核或转移瘤。PAL肿块的平均大小为5.5 cm,而其他双侧肾上腺肿块通常较小,通常小于5 cm此外,在双侧肾上腺肿物的病例中,肾上腺功能不全在57%的PAL和94%的结核病中被报道,而在嗜铬细胞瘤和转移中较少见如果在发烧和背部疼痛的患者中发现双侧肾上腺肿物(5cm),重要的是考虑PAL,评估肾上腺功能,并及时进行活检。里约热内卢清水:写作-原稿;数据管理;调查。Shogo Shirota:写作-评论和编辑;概念化;监督;项目管理。这项研究没有从公共、商业或非营利部门的机构获得任何具体的资助。作者宣称他们没有竞争利益。伦理批准声明:根据我们机构的政策,本病例报告不需要伦理批准。患者同意声明:患者在去世前就其医疗数据和相关图像的发表提供了书面知情同意。临床试验注册:无。本病例报告未使用以往发表的材料。患者在去世前提供了书面知情同意,以便公布其医疗数据和相关图像。
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引用次数: 0
Patient experience in community pharmacy services: A scoping review 社区药房服务的患者体验:范围综述
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-24 DOI: 10.1002/jgf2.70040
Chiho Kaneko, Shota Suzuki MPH, Ibuki Tanaka, Haruna Hiruma, Hiroshi Okada PhD

Background

The role of pharmacists in community settings is expanding, and understanding patient experience– an essential indicator of person-centered care–is crucial for improving pharmacy service quality. However, the extent to which patient experience has been studied in community pharmacies remains unclear. This scoping review aimed to explore the scope of research on patient experience in community pharmacies.

Methods

This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. A comprehensive literature search was conducted in October 2024 using PubMed, Web of Science, and Google Scholar with predefined keywords, including “patient-centered,” “experience,” and “community pharmacy.”

Results

Of the 121 records identified, 15 studies, published between 2008 and 2024, met the eligibility criteria. These studies were conducted in Australia (n = 4), the United States (n = 3), and the United Kingdom (n = 3), with six studies published in non-English languages. Study methodologies included qualitative (n = 7), quantitative (n = 5), and mixed (n = 2). Four studies used patient-reported experience measures (PREMs). Terminology for study participants varied, with “patients” (n = 10), “consumers” (n = 3), and “customers” (n = 1). In addition, one study included pharmacists (n = 1) and another included caregivers (n = 1).

Conclusion

This review emphasizes advancing person-centered care in pharmacy practice, with a growing focus on patient experience in community pharmacies. Future studies should develop and implement patient-reported experience measures tailored to different social contexts to enhance care and service evaluation.

背景药剂师在社区环境中的作用正在扩大,了解患者体验-以人为本的护理的基本指标-对提高药房服务质量至关重要。然而,对社区药房患者经验的研究程度仍不清楚。本综述旨在探讨社区药房患者体验研究的范围。方法本综述遵循系统评价的首选报告项目和范围评价的元分析扩展指南。2024年10月,使用PubMed、Web of Science和谷歌Scholar进行了一次全面的文献检索,其中预定义的关键词包括“以患者为中心”、“体验”和“社区药房”。在确定的121项记录中,2008年至2024年间发表的15项研究符合资格标准。这些研究分别在澳大利亚(n = 4)、美国(n = 3)和英国(n = 3)进行,其中6项研究以非英语语言发表。研究方法包括定性(n = 7)、定量(n = 5)和混合(n = 2)。四项研究使用了患者报告的体验测量(PREMs)。研究参与者的术语各不相同,有“病人”(n = 10)、“消费者”(n = 3)和“顾客”(n = 1)。此外,一项研究包括药剂师(n = 1),另一项研究包括护理人员(n = 1)。结论本综述强调在药学实践中推进以人为本的护理,并日益关注社区药房的患者体验。未来的研究应根据不同的社会背景制定和实施患者报告的经验措施,以加强护理和服务评估。
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引用次数: 0
Rethinking community-based clinical training in Japan: Toward a more effective model for increasing the number of general practice physicians 日本以社区为基础的临床培训的反思:朝着增加全科医生数量的更有效的模式发展
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-09 DOI: 10.1002/jgf2.70038
Masanobu Okayama MD, PhD

The effectiveness of Community-Based Clinical Training (CBCT) in increasing the number of general practice physicians remains uncertain. In Japan, where the population is rapidly aging and shrinking, the demand for general practice physicians has significantly escalated to ensure adequate health care for the public, particularly in rural and underserved areas. General practice physicians are expected to play a vital role in providing comprehensive and continuous care to the aging population. Therefore, finding an effective strategy to secure an adequate number of general practice physicians is a crucial social issue.

CBCT is considered a promising approach to addressing this issue. It provides students and residents opportunities to engage with various aspects of community healthcare, including outpatient care, home visiting care, nurse home care, preventive care, health education, and more, particularly in rural and underserved areas. First introduced in the United States, CBCT has been implemented in numerous countries. It has spread rapidly worldwide since the 1990s, and nearly all medical schools and teaching hospitals in Japan offer this clinical training program.

Several studies have examined the effects of CBCT. Trainees report that their experiences during CBCT profoundly influence their understanding of general practice. They acknowledge the importance of acquiring diverse perspectives, understanding the physician's role, recognizing the significance of community care, respecting individual lifestyles, addressing multimorbidity, navigating various healthcare settings, and collaborating with different professionals.1 This training has a positive short-term impact on attitudes and awareness related to general practice and community healthcare. Participants' ratings of their attitudes and awareness significantly improved after the training, not only in rural areas,1 but also in urban settings.2

However, the effect of CBCT is insufficient regarding career preferences for general practice physicians. The research conducted with graduates from a single medical university suggests that conventional CBCT might not be sufficient in Japan for effectively developing general practice physicians.3 Additionally, a study at one teaching hospital indicated no positive relationship between the amount of compulsory undergraduate education in community-based medicine and the subsequent rise in the number of residents choosing general practice majors in Japan.4

A Longitudinal Integrated Clerkship (LIC) is a novel model of CBCT where students participate in the comprehensive care of patients over time and maintain ongoing learning relationships with both patients and supervising clinicians across multiple disciplines. Although there is no definitive minimum duration for student placements in an LIC program, severa

基于社区的临床培训(CBCT)在增加全科医生数量方面的有效性仍不确定。在人口迅速老龄化和萎缩的日本,对全科医生的需求大幅增加,以确保公众,特别是农村和服务不足地区的公众获得充分的医疗保健。全科医生在为老年人口提供全面和持续的护理方面发挥着至关重要的作用。因此,找到一个有效的策略来确保足够数量的全科医生是一个至关重要的社会问题。CBCT被认为是解决这一问题的有希望的方法。它为学生和居民提供了参与社区医疗保健各个方面的机会,包括门诊护理、家访护理、护士之家护理、预防保健、健康教育等等,特别是在农村和服务不足的地区。CBCT首先在美国推出,现已在许多国家实施。自20世纪90年代以来,它在世界范围内迅速传播,日本几乎所有的医学院和教学医院都提供这种临床培训计划。一些研究已经检验了CBCT的效果。学员报告说,他们在CBCT期间的经历深刻地影响了他们对全科医学的理解。他们承认获得不同观点的重要性,理解医生的角色,认识到社区护理的重要性,尊重个人生活方式,解决多重疾病,适应不同的医疗保健环境,并与不同的专业人员合作这种培训在短期内对与全科医疗和社区保健有关的态度和认识产生了积极的影响。不仅在农村地区,而且在城市环境中,参与者对自己的态度和意识的评分在培训后显著提高。然而,CBCT对全科医生职业偏好的影响是不够的。对一所医科大学的毕业生进行的研究表明,传统的CBCT可能不足以在日本有效地培养全科医生此外,在一家教学医院进行的一项研究表明,日本社区医学的义务本科教育数量与随后选择全科专业的住院医师数量的增加之间没有正相关关系。4a纵向综合实习(LIC)是一种新型的CBCT模式,学生长期参与患者的综合护理,并与患者和监督临床医生保持持续的学习关系学科。虽然在LIC项目中没有明确的最短实习时间,但通常采用几个月或更长时间。与持续2-4周的传统CBCT相比,LIC提供了更长的社区卫生保健接触时间。这种在社区的长期沉浸让学生成为医疗保健团队的一员,并与社区深入接触。据报道,低收入国家的学生拥有发达的以患者为中心的沟通技巧,对医学的社会心理贡献有理解,并在更高层次的临床和认知技能方面表现出更强的准备。他们对病人承担了更多的责任,并报告说他们在处理道德困境方面更有信心。此外,参与农村纵向综合见习项目与毕业生从事农村职业和初级保健专业之间存在正相关关系LIC模型显示出潜力;然而,需要进一步的研究来确定这些好处是否适用于城市环境。2009年,日本初级保健协会为家庭医学引入了董事会认证。自2018年以来,一个独立的第三方组织管理了一个新的国家专业认证体系,其中包括全科医生。在采取这些行动之前,没有委员会对全科医生的认证;现在,这个领域的环境发生了巨大的变化。这种情况为增加全科医生的数量提供了一个极好的机会。然而,目前的CBCT对于全科医生的有效发展可能还存在不足,有几个方面需要改进。项目协调员必须重新考虑学习目标、学习环境、培训周期、学习内容和活动、学习风格、教学技巧、社区互动和其他相关因素。因此,需要开发更有效的CBCT。还需要更多的研究来确定CBCT是否确实可以增加全科医生的数量。我们希望这个模棱两可的研究问题能够在未来得到解决。 冈山正信:概念化;写作——原稿;写作——审阅和编辑。作者声明不存在利益冲突。
{"title":"Rethinking community-based clinical training in Japan: Toward a more effective model for increasing the number of general practice physicians","authors":"Masanobu Okayama MD, PhD","doi":"10.1002/jgf2.70038","DOIUrl":"https://doi.org/10.1002/jgf2.70038","url":null,"abstract":"<p>The effectiveness of Community-Based Clinical Training (CBCT) in increasing the number of general practice physicians remains uncertain. In Japan, where the population is rapidly aging and shrinking, the demand for general practice physicians has significantly escalated to ensure adequate health care for the public, particularly in rural and underserved areas. General practice physicians are expected to play a vital role in providing comprehensive and continuous care to the aging population. Therefore, finding an effective strategy to secure an adequate number of general practice physicians is a crucial social issue.</p><p>CBCT is considered a promising approach to addressing this issue. It provides students and residents opportunities to engage with various aspects of community healthcare, including outpatient care, home visiting care, nurse home care, preventive care, health education, and more, particularly in rural and underserved areas. First introduced in the United States, CBCT has been implemented in numerous countries. It has spread rapidly worldwide since the 1990s, and nearly all medical schools and teaching hospitals in Japan offer this clinical training program.</p><p>Several studies have examined the effects of CBCT. Trainees report that their experiences during CBCT profoundly influence their understanding of general practice. They acknowledge the importance of acquiring diverse perspectives, understanding the physician's role, recognizing the significance of community care, respecting individual lifestyles, addressing multimorbidity, navigating various healthcare settings, and collaborating with different professionals.<span><sup>1</sup></span> This training has a positive short-term impact on attitudes and awareness related to general practice and community healthcare. Participants' ratings of their attitudes and awareness significantly improved after the training, not only in rural areas,<span><sup>1</sup></span> but also in urban settings.<span><sup>2</sup></span></p><p>However, the effect of CBCT is insufficient regarding career preferences for general practice physicians. The research conducted with graduates from a single medical university suggests that conventional CBCT might not be sufficient in Japan for effectively developing general practice physicians.<span><sup>3</sup></span> Additionally, a study at one teaching hospital indicated no positive relationship between the amount of compulsory undergraduate education in community-based medicine and the subsequent rise in the number of residents choosing general practice majors in Japan.<span><sup>4</sup></span></p><p>A Longitudinal Integrated Clerkship (LIC) is a novel model of CBCT where students participate in the comprehensive care of patients over time and maintain ongoing learning relationships with both patients and supervising clinicians across multiple disciplines. Although there is no definitive minimum duration for student placements in an LIC program, severa","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 5","pages":"383-384"},"PeriodicalIF":2.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with the cancer survivorship care practices of primary care physicians: A cross-sectional questionnaire study in Japan 与初级保健医生癌症生存护理实践相关的因素:日本横断面问卷调查研究
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-06 DOI: 10.1002/jgf2.70037
Akihiro Nishi MD, Hiroki Matsui MPH, Takashi Chinen MD, PhD, Sachi Takaoka MD, Takuji Seo MD, PhD, Satoshi Kanke MD, PhD, Teruhisa Azuma MD

Background

The involvement of primary care physicians (PCPs) is essential to meet the diverse needs of cancer survivors, yet their engagement remains insufficient. Consequently, identifying the factors associated with PCPs' practices in each component of cancer survivorship care is crucial. However, there is no study on the factors for individual care components. Therefore, we conducted a survey to identify the involvement and factors related to PCPs' practice of each component of cancer survivorship care.

Methods

A web-based questionnaire was distributed to 1091 family physicians in Japan. We identified four cancer survivorship care components: surveillance of recurrence, care for late effects, care for psychological problems, and care for social problems. The association between the practice of the components and the presence of knowledge or information resources, access to oncologists, and requests from patients and oncologists was evaluated.

Results

A total of 191 PCPs (response rate: 17.5%) responded, and 180 were included in the analysis. Multivariate logistic regression analyses revealed that knowledge or information resources were associated with care for late effects (odds ratio (OR), 5.09; 95% confidence interval (CI), 1.54–23.1) and psychological problems (OR, 4.77; 95% CI, 1.52–17.8). Access to oncologists was associated with surveillance of recurrence (OR, 2.97; 95% CI, 1.08–8.75). Requests from patients and oncologists were associated with almost all survivorship care components.

Conclusions

Requests from patients and oncologists might be key to PCPs' involvement in cancer survivorship care. PCPs need to be proactive in identifying patient needs and fostering trust from patients and oncologists for better cancer survivorship care.

背景:初级保健医生(pcp)的参与对于满足癌症幸存者的多样化需求至关重要,但他们的参与仍然不足。因此,在癌症生存护理的每个组成部分中,确定与pcp实践相关的因素至关重要。然而,对个体护理成分的影响因素尚无研究。因此,我们进行了一项调查,以确定pcp在癌症生存护理的每个组成部分的参与和相关因素。方法对日本1091名家庭医生进行网络问卷调查。我们确定了癌症生存期护理的四个组成部分:复发监测、晚期影响护理、心理问题护理和社会问题护理。评估了组件的实践与知识或信息资源的存在、与肿瘤学家的接触以及患者和肿瘤学家的要求之间的关系。结果共有191个pcp应答,有效率为17.5%,其中180个纳入分析。多因素logistic回归分析显示,知识或信息资源与晚期效应护理相关(优势比(or), 5.09;95%可信区间(CI), 1.54-23.1)和心理问题(OR, 4.77; 95% CI, 1.52-17.8)。与肿瘤医生接触与复发监测相关(OR, 2.97; 95% CI, 1.08-8.75)。来自患者和肿瘤学家的要求与几乎所有的生存护理组成部分相关。结论:患者和肿瘤学家的要求可能是pcp参与癌症生存护理的关键。pcp需要积极主动地识别患者的需求,并培养患者和肿瘤学家对更好的癌症生存护理的信任。
{"title":"Factors associated with the cancer survivorship care practices of primary care physicians: A cross-sectional questionnaire study in Japan","authors":"Akihiro Nishi MD,&nbsp;Hiroki Matsui MPH,&nbsp;Takashi Chinen MD, PhD,&nbsp;Sachi Takaoka MD,&nbsp;Takuji Seo MD, PhD,&nbsp;Satoshi Kanke MD, PhD,&nbsp;Teruhisa Azuma MD","doi":"10.1002/jgf2.70037","DOIUrl":"https://doi.org/10.1002/jgf2.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The involvement of primary care physicians (PCPs) is essential to meet the diverse needs of cancer survivors, yet their engagement remains insufficient. Consequently, identifying the factors associated with PCPs' practices in each component of cancer survivorship care is crucial. However, there is no study on the factors for individual care components. Therefore, we conducted a survey to identify the involvement and factors related to PCPs' practice of each component of cancer survivorship care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A web-based questionnaire was distributed to 1091 family physicians in Japan. We identified four cancer survivorship care components: surveillance of recurrence, care for late effects, care for psychological problems, and care for social problems. The association between the practice of the components and the presence of knowledge or information resources, access to oncologists, and requests from patients and oncologists was evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 191 PCPs (response rate: 17.5%) responded, and 180 were included in the analysis. Multivariate logistic regression analyses revealed that knowledge or information resources were associated with care for late effects (odds ratio (OR), 5.09; 95% confidence interval (CI), 1.54–23.1) and psychological problems (OR, 4.77; 95% CI, 1.52–17.8). Access to oncologists was associated with surveillance of recurrence (OR, 2.97; 95% CI, 1.08–8.75). Requests from patients and oncologists were associated with almost all survivorship care components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Requests from patients and oncologists might be key to PCPs' involvement in cancer survivorship care. PCPs need to be proactive in identifying patient needs and fostering trust from patients and oncologists for better cancer survivorship care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 5","pages":"465-474"},"PeriodicalIF":2.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy 孤立性颈部震颤作为长期阿立哌唑治疗的罕见迟发效应
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-05-27 DOI: 10.1002/jgf2.70032
Ryuichi Minoda Sada MD, Saki Sada Minoda MD
<p>Aripiprazole, a third-generation antipsychotic, demonstrates the pharmacodynamic characteristics of partial agonism, functional selectivity, and serotonin–dopamine activity modulation, representing the latest paradigm in managing major psychiatric conditions, including Bipolar II disorders.<span><sup>1</sup></span> Aripiprazole is also associated with a low incidence of tremors and is recommended as an alternative for patients experiencing tremors caused by other antipsychotics.<span><sup>2</sup></span> Here, we describe a case of isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy.</p><p>A 34-year-old female with a history of ovarian cystectomy and ongoing treatment for Bipolar II Disorder presented with a 3-month history of head tremors. She had been taking aripiprazole (3 mg/day) for over a decade with no other medications and demonstrated good medication adherence. Her mental state has remained stable over the past few years with the same dose of aripiprazole; apart from the tremors, there have been no relevant physical symptoms. She also denied having dystonic features, such as torticollis and hypertonia, and other extrapyramidal symptoms, including rigidity, hand tremor, reduced arm swing, bradykinesia, difficulty in maintaining posture, or a mask-like face. Working in an office environment, she had no known exposure to specialized chemicals. Additionally, her medical history revealed no instances of international travel or interaction with animals, and there was no evidence of sexual activity involving multiple partners. She was alert and vital signs were stable.</p><p>Physical examination revealed a resting tremor of the neck, approximately 3 Hz in the anterior–posterior direction (Video S1), with no other significant neurological findings. There were also no signs suggesting other extrapyramidal symptoms, such as Myerson's sign or the retropulsion test. Suspecting drug-induced tremor, aripiprazole was discontinued, leading to the complete resolution of the tremor within a week (Video S1). Therefore, she was diagnosed with isolated tardive neck tremor due to chronic aripiprazole use. Following psychiatric deterioration a month later, aripiprazole was resumed at 3 mg every 3 days, maintaining psychiatric stability without tremor recurrence.</p><p>Tardive tremor is a relatively rare component of drug-induced extrapyramidal symptoms, accounting for 2.4% of antipsychotic-induced extrapyramidal side effects.<span><sup>3</sup></span> This condition is commonly observed in patients who have been taking medication for an average period of more than 10 years<span><sup>4</sup></span>; thus, the absence of immediate onset should not preclude the consideration of drug-related side effects. While tremors are commonly present in the limbs, rare cases like this case involve head and neck manifestations.<span><sup>4</sup></span> Tardive tremors persist even after discontinuation of the causative medication in half of report
阿立哌唑是第三代抗精神病药物,具有部分激动作用、功能选择性和5 -羟色胺-多巴胺活性调节的药效学特征,代表了治疗包括双相情感障碍在内的主要精神疾病的最新范例阿立哌唑也与震颤发生率低有关,被推荐作为其他抗精神病药物引起震颤的患者的替代药物在这里,我们描述一个病例孤立的颈部震颤作为一个罕见的迟发效应长期阿立哌唑治疗。34岁女性,有卵巢囊肿切除术史,目前正在接受双相情感障碍治疗,有3个月的头部震颤史。她服用阿立哌唑(3毫克/天)超过十年,没有其他药物,并表现出良好的药物依从性。她的精神状态在过去几年中一直保持稳定,服用了相同剂量的阿立哌唑;除了震颤,没有相关的身体症状。她还否认有肌张力障碍特征,如斜颈和强直,以及其他锥体外系症状,包括强直、手颤、手臂摆动减少、运动迟缓、难以保持姿势或面具样脸。她在办公环境中工作,没有接触到特殊化学品。此外,她的病史显示没有国际旅行或与动物接触的情况,也没有与多名伴侣发生性行为的证据。她神志清醒,生命体征稳定。体格检查显示颈部静息性震颤,前后方向约3hz(视频S1),未见其他显著神经学表现。也没有迹象表明其他锥体外系症状,如迈尔森征或反推试验。怀疑药物性震颤,停用阿立哌唑,导致震颤在一周内完全消退(视频S1)。因此,她被诊断为长期使用阿立哌唑引起的孤立性迟发性颈部震颤。精神恶化1个月后,重新使用阿立哌唑,每3天3mg,保持精神稳定,无震颤复发。迟发性震颤是药物性锥体外系症状中相对罕见的组成部分,占抗精神病药物性锥体外系副作用的2.4%这种情况常见于平均服药时间超过10年的患者4;因此,没有立即发病不应排除考虑药物相关的副作用。虽然震颤通常出现在四肢,但像本例这样的病例很少出现在头颈部在一半的报告病例中,迟发性震颤甚至在停用致病性药物后仍持续存在如果没有观察到改善,应考虑使用丁苯那嗪总之,认识到阿立哌唑引起的震颤可能在长期使用中发生,并且可能只影响颈部,这一点至关重要。任何新发症状都应考虑药物引起的原因。田田龙一:概念化;写作——原稿;可视化;写作——审阅和编辑。Saki Minoda Sada:可视化;写作——审阅和编辑;监督。这项研究没有从公共、商业或非营利部门的资助机构获得任何具体的资助。作者明确表示,本文不存在任何利益冲突。伦理批准声明:根据日本国家指南,单个患者病例报告不需要机构审查委员会批准。患者同意声明:本病例报告的发表,包括任何附带的图像和视频,均已获得患者的知情同意。该患者的姓名已被保密。临床试验注册:无。
{"title":"Isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy","authors":"Ryuichi Minoda Sada MD,&nbsp;Saki Sada Minoda MD","doi":"10.1002/jgf2.70032","DOIUrl":"https://doi.org/10.1002/jgf2.70032","url":null,"abstract":"&lt;p&gt;Aripiprazole, a third-generation antipsychotic, demonstrates the pharmacodynamic characteristics of partial agonism, functional selectivity, and serotonin–dopamine activity modulation, representing the latest paradigm in managing major psychiatric conditions, including Bipolar II disorders.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Aripiprazole is also associated with a low incidence of tremors and is recommended as an alternative for patients experiencing tremors caused by other antipsychotics.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Here, we describe a case of isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy.&lt;/p&gt;&lt;p&gt;A 34-year-old female with a history of ovarian cystectomy and ongoing treatment for Bipolar II Disorder presented with a 3-month history of head tremors. She had been taking aripiprazole (3 mg/day) for over a decade with no other medications and demonstrated good medication adherence. Her mental state has remained stable over the past few years with the same dose of aripiprazole; apart from the tremors, there have been no relevant physical symptoms. She also denied having dystonic features, such as torticollis and hypertonia, and other extrapyramidal symptoms, including rigidity, hand tremor, reduced arm swing, bradykinesia, difficulty in maintaining posture, or a mask-like face. Working in an office environment, she had no known exposure to specialized chemicals. Additionally, her medical history revealed no instances of international travel or interaction with animals, and there was no evidence of sexual activity involving multiple partners. She was alert and vital signs were stable.&lt;/p&gt;&lt;p&gt;Physical examination revealed a resting tremor of the neck, approximately 3 Hz in the anterior–posterior direction (Video S1), with no other significant neurological findings. There were also no signs suggesting other extrapyramidal symptoms, such as Myerson's sign or the retropulsion test. Suspecting drug-induced tremor, aripiprazole was discontinued, leading to the complete resolution of the tremor within a week (Video S1). Therefore, she was diagnosed with isolated tardive neck tremor due to chronic aripiprazole use. Following psychiatric deterioration a month later, aripiprazole was resumed at 3 mg every 3 days, maintaining psychiatric stability without tremor recurrence.&lt;/p&gt;&lt;p&gt;Tardive tremor is a relatively rare component of drug-induced extrapyramidal symptoms, accounting for 2.4% of antipsychotic-induced extrapyramidal side effects.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; This condition is commonly observed in patients who have been taking medication for an average period of more than 10 years&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;; thus, the absence of immediate onset should not preclude the consideration of drug-related side effects. While tremors are commonly present in the limbs, rare cases like this case involve head and neck manifestations.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Tardive tremors persist even after discontinuation of the causative medication in half of report","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 6","pages":"655-656"},"PeriodicalIF":2.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An infant with Kawasaki disease having gastrointestinal bleeding due to multiple gastric ulcers 一名患有川崎病的婴儿,由于多重胃溃疡而出现胃肠道出血
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-05-23 DOI: 10.1002/jgf2.70035
Takeru Kanazawa MD, Tomokazu Nakagami MD, PhD, Jyoji Yoshizawa MD, PhD, Yoshifusa Abe MD, PhD

Kawasaki disease (KD) is an acute systemic vasculitis managed mainly through intravenous immunoglobulin (IVIG), aspirin, and steroids. Although gastrointestinal symptoms are common, gastrointestinal bleeding is rare. We present the case of an 11-month-old girl with incomplete KD who developed severe gastrointestinal bleeding due to multiple gastric ulcers, despite prophylactic H2-receptor antagonist therapy, requiring blood transfusion therapy. This case illustrates that gastrointestinal bleeding can occur as a direct consequence of KD and from the combined effects of corticosteroids and nonsteroidal anti-inflammatory drugs. It emphasizes the need for vigilant monitoring and further research to efficiently prevent gastrointestinal bleeding in patients with KD.

川崎病(KD)是一种急性全身性血管炎,主要通过静脉注射免疫球蛋白(IVIG)、阿司匹林和类固醇治疗。虽然胃肠道症状是常见的,消化道出血是罕见的。我们报告了一个11个月大的不完全性KD女孩的病例,尽管预防性的h2受体拮抗剂治疗,但由于多发性胃溃疡,她出现了严重的胃肠道出血,需要输血治疗。本病例表明,胃肠道出血可作为KD的直接后果以及皮质类固醇和非甾体抗炎药的联合作用而发生。它强调需要警惕监测和进一步的研究,以有效地预防胃肠道出血患者KD。
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引用次数: 0
Evaluating antimicrobial effectiveness in acute uncomplicated cystitis: A retrospective single-center study 评估急性无并发症膀胱炎的抗菌效果:一项回顾性单中心研究
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-05-22 DOI: 10.1002/jgf2.70034
Takuhisa Nukaya MD, PhD, Kiyohito Ishikawa MD, PhD, Ryoichi Shiroki MD, PhD

Background

Acute uncomplicated cystitis (AUC) is a urinary tract infection and is generally treated using antimicrobial therapy. Escherichia coli is the main causative agent of AUC. Recently, the prevalence of fluoroquinolone (FQ)-resistant-E. coli has demonstrated a noticeable increase. In this study, we aimed to investigate the effectiveness of appropriate antimicrobial treatment in AUC caused by E. coli in real-world clinical settings.

Methods

This retrospective cohort study reviewed the records of patients with AUC treated at the urology department of Minami Cooperative Hospital between April 2016 and December 2020. Effectiveness was defined as clinical improvement.

Results

The study cohort of 730 patients had a median age of 65.5 years (interquartile range, 57–78 years) and 23.2% were aged <55 years. E. coli was detected in 73.4% of patients, of whom 26.7% had levofloxacin (LVFX)-resistant strains. LVFX-resistant E. coli was associated with age ≥55 years and recurrent cases. Effectiveness was determined in 75.1% of cases, of which 75% complied with the Japanese or other international guidelines. The overall treatment effectiveness was highest with β-lactam (BL)/β-lactamase inhibitor (BLI) combinations (94.7%). The effectiveness of first- and third-generation cephalosporins (CPs) was 81.1–83.3%, and that of FQs and sulfamethoxazole–trimethoprim (ST) was 82.6–83.8%. For LVFX-resistant E. coli, the treatment effectiveness was highest (100%) with BL/BLI combinations, intermediate (75–81%) with first- and third-generation CPs and ST, and lowest (50%) with FQs.

Conclusions

BL/BLI combinations had the highest effectiveness for the treatment of AUC.

背景:急性无并发症膀胱炎(AUC)是一种泌尿道感染,通常采用抗菌药物治疗。大肠杆菌是AUC的主要病原体。近年来,氟喹诺酮(FQ)耐药e的流行。大肠杆菌的数量明显增加。在这项研究中,我们的目的是研究在现实世界的临床环境中,大肠杆菌引起的AUC的适当抗菌治疗的有效性。方法回顾性队列研究回顾了2016年4月至2020年12月在南合作医院泌尿外科治疗的AUC患者的记录。疗效定义为临床改善。结果730例患者中位年龄为65.5岁(四分位间距为57 ~ 78岁),其中年龄为55岁的患者占23.2%。73.4%的患者检出大肠杆菌,其中26.7%为左氧氟沙星(LVFX)耐药菌株。lvfx耐药大肠杆菌与年龄≥55岁和复发病例相关。75.1%的病例确定有效,其中75%符合日本或其他国际指南。β-内酰胺(BL)/β-内酰胺酶抑制剂(BLI)联合治疗的总疗效最高(94.7%)。第一代和第三代头孢菌素(CPs)的有效率为81.1 ~ 83.3%,FQs和磺胺甲氧唑-甲氧苄啶(ST)的有效率为82.6 ~ 83.8%。对于lvfx耐药大肠杆菌,用BL/BLI组合治疗效果最高(100%),用第一代和第三代CPs和ST治疗效果中等(75-81%),用FQs治疗效果最低(50%)。结论BL/BLI联合治疗AUC效果最佳。
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引用次数: 0
Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review 管理老年人慢性便秘的关键错误以及如何避免它们:叙述回顾
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-05-22 DOI: 10.1002/jgf2.70033
Madunil Niriella MD, FRCP, AGAF, Hiruni Jayasena MD, MRCP, Prathibha Wijesingha MBBS, Janaka de Silva MD, FRCP, PhD

Objectives

This narrative review identifies pitfalls in managing constipation in older adults and provides evidence-based recommendations to avoid them.

Methods

A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in older adults. Randomized controlled trials, meta-analyses, systematic reviews, evidence-based clinical practice guidelines, and selected expert consensus statements and narrative reviews were included.

Results

Constipation significantly impacts quality of life and healthcare costs in older adults. It is not a consequence of normal aging but results from decreased mobility, medications, underlying diseases, and pelvic floor dysfunction. A stepwise diagnostic and therapeutic approach is recommended, recognizing that multiple etiologic mechanisms often coexist in elderly patients. Before pharmacological interventions, initial management should include thorough history-taking, physical examination, medication review, and dietary and lifestyle modifications.

Conclusions

Common management mistakes include inadequate assessment, overlooking underlying conditions, insufficient diagnostic workup, ignoring multifactorial causes, premature medication use, and neglecting patient education. Effective management requires systematic evaluation and personalized interventions.

Clinical Implications

Clinicians should adopt a stepwise approach, from clinical assessment to diagnostic testing or medications. Patient education and individualized treatment based on comorbidities and preferences are essential, with regular efficacy reassessment.

目的:本综述确定了老年人便秘管理的陷阱,并提供了基于证据的建议,以避免它们。方法选择PubMed、MEDLINE、Embase和Cochrane图书馆等电子数据库进行文献检索,以确定老年人便秘管理的相关文献。包括随机对照试验、荟萃分析、系统评价、循证临床实践指南以及选定的专家共识声明和叙述性评价。结果便秘显著影响老年人的生活质量和医疗费用。它不是正常衰老的结果,而是活动能力下降、药物、潜在疾病和盆底功能障碍的结果。认识到多种病因机制在老年患者中经常共存,建议采用分步诊断和治疗方法。在药物干预之前,初始管理应包括彻底的病史记录、体格检查、药物回顾、饮食和生活方式的改变。结论常见的管理失误包括评估不充分、忽视基础疾病、诊断检查不充分、忽视多因素病因、过早用药和忽视患者教育。有效的管理需要系统的评估和个性化的干预。临床意义临床医生应该采取循序渐进的方法,从临床评估到诊断测试或药物治疗。患者教育和基于合并症和偏好的个体化治疗是必要的,并定期进行疗效重新评估。
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引用次数: 0
Understanding clinical ambiguity in family medicine: Implications for training and global practice 理解家庭医学中的临床歧义:对培训和全球实践的影响
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-05-21 DOI: 10.1002/jgf2.70036
Manuel Millán-Hernández Master's Degree in Health Management, Daniela F. Albarrán-Pérez Master's Degree in Educational Assessment

We read with great interest the recent article by Fujikawa et al., “Family physicians have greater ambiguity tolerance in the clinical context: a nationwide cross-sectional study”.1 The authors' contribution is timely and valuable, particularly for those of us involved in postgraduate training and professional development in family medicine.

Their findings reinforce what we often observe in our own practice and in the mentoring of new physicians: that tolerance for clinical ambiguity is an essential characteristic in primary care. This is especially true when facing diagnostic uncertainty, multimorbidity, and limited access to immediate investigations—hallmarks of both rural and urban family practice. The use of the J-TAMSAD scale represents a validated and appropriate method for evaluating this cognitive-emotional construct.2

While the cross-sectional methodology effectively highlights differences in tolerance levels between physicians, it also opens doors to several future inquiries. First, a longitudinal design could clarify how ambiguity tolerance evolves over time, from undergraduate training to clinical maturity.3 Second, qualitative inquiry may help explore how physicians conceptualize and respond to ambiguity in culturally distinct ways. In our Latin American context, ambiguity is not only a clinical challenge but also a sociopolitical and systemic reality. Family physicians often manage patients with complex needs, in under-resourced environments, without clear protocols or referral pathways.4

Moreover, we wish to underline the importance of ambiguity tolerance as a teachable and assessable competency. It is closely related to emotional resilience, clinical reasoning, and professional identity formation. Curricular models that integrate case-based learning, reflection, and feedback on uncertainty management may help future physicians to not only tolerate but also effectively navigate ambiguity.5 This is of particular importance in global family medicine, where adaptability to diverse contexts is essential for equitable care.

Fujikawa et al. provide critical evidence to support a broader, competency-based approach to medical education and ongoing professional development. Their article should stimulate further research and international dialogue, especially among educators and clinicians working in complex, variable, and resource-constrained settings like those frequently found across Latin America.

Manuel Millán-Hernández: Conceptualization; methodology; investigation; supervision; writing – review and editing. Daniela F. Albarrán-Pérez: Conceptualization; investigation; formal analysis; writing – original draft.

The authors have stated explicitly that there are no conflicts of interest in connection with this article.

我们饶有兴趣地阅读了Fujikawa等人最近的一篇文章,“家庭医生在临床环境中具有更大的歧义耐受性:一项全国性的横断面研究”作者的贡献是及时和有价值的,特别是对我们这些参与研究生培训和家庭医学专业发展的人。他们的发现强化了我们在自己的实践和指导新医生时经常观察到的:对临床模糊性的容忍是初级保健的一个基本特征。在面临诊断不确定性、多病性和获得即时调查的机会有限(农村和城市家庭实践的特点)时尤其如此。J-TAMSAD量表的使用是一种有效的、适当的评估这种认知-情绪结构的方法虽然横断面方法有效地突出了医生之间耐受水平的差异,但它也为未来的一些调查打开了大门。首先,纵向设计可以阐明从本科训练到临床成熟的模糊耐受性是如何随时间演变的其次,定性调查可能有助于探索医生如何概念化和回应歧义在文化上不同的方式。在我们拉丁美洲的背景下,模糊性不仅是临床挑战,也是社会政治和系统现实。家庭医生经常在资源不足的环境中管理有复杂需求的患者,没有明确的协议或转诊途径此外,我们希望强调歧义容忍作为一种可教可评的能力的重要性。它与情绪弹性、临床推理和职业认同形成密切相关。整合基于案例的学习、反思和不确定性管理反馈的课程模式,可能有助于未来的医生不仅能够容忍,而且能够有效地驾驭模糊性这在全球家庭医学中尤其重要,因为适应不同情况对公平护理至关重要。Fujikawa等人提供了关键证据,支持对医学教育和持续的专业发展采取更广泛的、基于能力的方法。他们的文章应该激发进一步的研究和国际对话,特别是在拉丁美洲经常发现的复杂、可变和资源有限的环境中工作的教育工作者和临床医生。Manuel Millán-Hernández:概念化;方法;调查;监督;写作——审阅和编辑。Daniela F. Albarrán-Pérez:概念化;调查;正式的分析;写作-原稿。作者明确表示,本文不存在任何利益冲突。
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引用次数: 0
Effects of a two-night hospitalization program as a specific health guidance on obesity and cardiovascular disease risk factors 两夜住院计划对肥胖和心血管疾病危险因素的具体健康指导效果
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-05-19 DOI: 10.1002/jgf2.70031
Maki Okazaki MD, Takeshi Katsuki MD, Hideaki Kurata MD/PhD, Shinichi Tanaka MD, Hajime Tanaka MD, Toshihide Kawai MD/PhD

Background

To assess the effects of a two-night hospitalization program conducted at our hospital as part of a domestic health guidance system. This program is designed for lifestyle modification within a health checkup framework for metabolic syndrome.

Methods

This is a single-center, retrospective observational study. We reviewed the medical records of 170 subjects who completed the two-night hospitalization program between June 1, 2019, and October 31, 2023. The ideal dietary caloric intake was calculated based on standard body weight (kg) × 25 kcal/kg. Participants were advised to maintain a regular lifestyle and received face-to-face instruction from nurses, nutritionists, physiotherapists, technicians, and physicians. We instructed the patients to visit the outpatient clinic twice, one month and three months after discharge. We compared body weight, systolic and diastolic blood pressure, and various metabolic parameters from those recorded before the program to the final outpatient visit after the program.

Results

Roughly half of the participants had been previously diagnosed with obesity and metabolic syndrome. At the second outpatient visit after completing the program, participants showed a significant body weight reduction (71.6 ± 13.5 kg vs. 70.1 ± 13.3 kg, p < 0.001). Additionally, significant reductions in blood pressure and improvements in liver enzymes, glucose, and lipid metabolism were observed. Correlation analysis indicated that weight loss was associated with the amelioration of multiple metabolic abnormalities.

Conclusions

The findings suggest that the two-night hospitalization program may offer significant benefits for managing coronary risk factors associated with metabolic syndrome.

背景:评估作为国内健康指导系统一部分的两夜住院计划在我院实施的效果。这个程序是在代谢综合征的健康检查框架内设计的生活方式改变。方法本研究为单中心回顾性观察性研究。我们回顾了170名在2019年6月1日至2023年10月31日期间完成两晚住院计划的受试者的医疗记录。以标准体重(kg) × 25 kcal/kg计算理想膳食热量摄入。参与者被建议保持有规律的生活方式,并接受护士、营养学家、物理治疗师、技术人员和医生的面对面指导。我们指导患者分别在出院后1个月和3个月到门诊就诊两次。我们比较了项目前记录的体重、收缩压和舒张压以及各种代谢参数,以及项目后最后一次门诊就诊的数据。结果:大约一半的参与者之前被诊断患有肥胖和代谢综合征。在完成项目后的第二次门诊就诊时,参与者的体重明显减轻(71.6±13.5 kg vs. 70.1±13.3 kg, p < 0.001)。此外,观察到血压显著降低,肝酶、葡萄糖和脂质代谢改善。相关分析表明,体重减轻与多种代谢异常的改善有关。结论:研究结果表明,两夜住院治疗方案可能对控制与代谢综合征相关的冠状动脉危险因素有显著益处。
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Journal of General and Family Medicine
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