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Egyptian Journal of Pediatric Allergy and Immunology最新文献

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Abstracts from International Publications 国际出版物摘要
IF 0.3 Pub Date : 2021-04-01 DOI: 10.21608/EJPA.2021.164799
N. Heshmat
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引用次数: 0
The Potential Effect of Dietary Modifications on the Management of Food Allergies 饮食调整对食物过敏管理的潜在影响
IF 0.3 Pub Date : 2021-04-01 DOI: 10.21608/EJPA.2021.60350.1022
Caner Ozyildirim, N. Ayhan
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引用次数: 0
Patterns of sensitization to food allergens among allergic adults and children following-up in Zagazig university hospitals, Egypt 在埃及扎加齐格大学医院随访的过敏成人和儿童对食物过敏原的致敏模式
IF 0.3 Pub Date : 2021-04-01 DOI: 10.21608/EJPA.2021.44948.1013
R. E. El Shabrawy, Nehal El Shabrawy, Dina S. El-rafey
INTRODUCTION It was thought that food allergy (FA) in the developing world was rare, but emerging epidemiological data have shown otherwise in the recent decade. This could be attributed to the previous under-recognition or underreporting of FA prevalence. Indeed, the health burden of food allergy is anticipated to rise substantially in the next decade. Food allergy present in different forms, including urticaria, angioedema, exacerbation of allergic rhinitis, asthma, or atopic dermatitis. Food allergic patients with asthma have a higher risk of developing life-threatening food-induced reactions and an asthmatic patient with a food allergy can have higher rates of morbidity and mortality associated with asthma. The most serious consequence of food allergy is anaphylaxis. Food allergy has significant deleterious effects on family economics, social interactions, school and work attendance, and health-related quality of life. Children with multiple food allergies face many nutritional problems as a consequence of an unsupervised elimination diet, which may lead to failure to thrive. There is a lack of reliable data regarding FA in most developing countries, including Egypt. 1,6 This study aimed to uncover some aspects of IgE mediated FA among the Egyptian population. We sought to explore the frequency of food sensitization among a sample of allergic patients and determine the common sensitizing food allergens among those patients.
人们认为食物过敏(FA)在发展中国家是罕见的,但最近十年新出现的流行病学数据却显示出相反的情况。这可能归因于以前对FA患病率的认识不足或报告不足。事实上,食物过敏的健康负担预计将在未来十年大幅上升。食物过敏表现为不同形式,包括荨麻疹、血管性水肿、变应性鼻炎加重、哮喘或特应性皮炎。患有哮喘的食物过敏患者发生危及生命的食物引起的反应的风险更高,患有食物过敏的哮喘患者与哮喘相关的发病率和死亡率更高。食物过敏最严重的后果是过敏反应。食物过敏对家庭经济、社会交往、上学和工作出勤率以及与健康相关的生活质量都有显著的有害影响。患有多种食物过敏的儿童由于没有监督的消除饮食而面临许多营养问题,这可能导致无法茁壮成长。在大多数发展中国家,包括埃及,缺乏关于FA的可靠数据。本研究旨在揭示埃及人群中IgE介导的FA的某些方面。我们试图探索过敏患者样本中食物致敏的频率,并确定这些患者中常见的致敏食物过敏原。
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引用次数: 0
Wheat allergy 小麦过敏
IF 0.3 Pub Date : 2020-10-03 DOI: 10.1016/b978-0-12-821715-3.00009-5
Z. El-Sayed, G. Shousha
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引用次数: 76
The Pediatric Allergy and Immunology Unit of Ain Shams University in times of SARS-CoV-2 pandemic: approach and challenges 在严重急性呼吸系统综合征冠状病毒2型大流行期间,艾因沙姆斯大学儿科过敏和免疫学部门:方法和挑战
IF 0.3 Pub Date : 2020-10-03 DOI: 10.21608/ejpa.2020.117833
Y. El-Gamal, Z. El-Sayed, E. Hossny, S. Reda, D. El-Ghoneimy, Rasha H. El-Owaidy, N. Radwan, G. Shousha, A. Elmekkawy, Amal Lotfy, Mariam Abdelnaby, Roba Al-Gaweesh, Rana Zakaria, Mostafa El-Amin
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引用次数: 0
2019 ARIA Care pathways for allergic rhinitis – Egypt 2019 ARIA过敏性鼻炎护理途径-埃及
IF 0.3 Pub Date : 2020-04-01 DOI: 10.21608/ejpa.2020.81763
Y. El-Gamal, Rasha H. El-Owaidy, S. El-Sayed, Z. El-Sayed, E. Hossny, S. Reda, C. Bachert, W. Fokkens, T. Haahtela, P. Hellings, L. Klimek, N. Papadopoulos, N. Pham‐Thi, O. Pfaar, A. Valiulis, M. Ventura, G. Onorato, W. Czarlewski, A. Bedbrook, J. Bousquet
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引用次数: 0
Editorial 编辑
IF 0.3 Pub Date : 2020-04-01 DOI: 10.21608/ejpa.2020.80619
Y. El-Gamal
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引用次数: 0
Health-related quality of life assessment using EQ-5D-Y questionnaire in a group of Egyptian asthmatic children 用EQ-5D-Y问卷评价埃及哮喘儿童健康相关生活质量
IF 0.3 Pub Date : 2020-04-01 DOI: 10.21608/ejpa.2020.81766
E. Hossny, Rasha H. El-Owaidy, B. A. Raouf, Samia Aboajela A. Innajih
hildren's quality of life. We sought to investigate the health-related quality of life (HRQoL) in a sample of Egyptian asthmatic children. Methods: A cross-sectional study was conducted in the Pediatric Allergy and Immunology Unit of Ain Shams University, including three groups of age and gender-matched children, aged 6-12 years; an asthma group (n=100), non-asthmatic group with respiratory tract infections (n=114), and a healthy control group (n=100). The EQ-5D-Y questionnaire was used to evaluate the HRQoL in each study group. This questionnaire also comprises a visual analogue scale (VAS) which is scored from zero (worst) to 100 (best) as judged by the patient. Results: HRQoL assessment revealed that 86% of the asthmatic children faced problems with their daily activities, 43 % had worries, sadness and unhappiness and 22% had mobility problems (walking around). Thirteen percent of the cases expressed some pain or discomfort due to their disease, while self-care was the least affected (6%). Parameters of mobility, doing usual activities, feeling worried or sad were more frequently affected among the asthmatics in comparison to the other two groups (X2 = 37.02, 46.38, 22.90, respectively with p <0.001). Enrolled asthmatic children showed the lowest values of visual analogue scale (VAS) scores (mean ± SD: 72.2 ± 24.6) in comparison to the infection and healthy control groups (mean ± SD: 84.6 ± 12, 92.8 ± 9.6, respectively; f = 39.03; p value = 0.001). Conclusion: Asthma has a significant adverse impact on HRQoL of children and the EQ-5D-Y questionnaire could be an applicable instrument to measure their quality of life.
儿童的生活质量。我们试图调查埃及哮喘儿童样本的健康相关生活质量(HRQoL)。方法:在艾因沙姆斯大学儿童过敏和免疫学部门进行横断面研究,包括三组年龄和性别匹配的儿童,6-12岁;哮喘组(n=100)、非哮喘呼吸道感染组(n=114)和健康对照组(n=100)。采用EQ-5D-Y问卷评估各研究组的HRQoL。该问卷还包括一个视觉模拟量表(VAS),由患者判断,评分从0(最差)到100(最好)。结果:HRQoL评估显示,86%的哮喘儿童存在日常活动问题,43%的哮喘儿童存在担忧、悲伤和不快乐,22%的哮喘儿童存在活动障碍(行走)。13%的病例表示因疾病而感到疼痛或不适,而自我保健受到的影响最小(6%)。哮喘患者在活动能力、日常活动、焦虑、悲伤等指标上受影响的频率高于其他两组(X2 = 37.02、46.38、22.90,p <0.001)。哮喘患儿的视觉模拟评分(VAS)最低(平均±SD: 72.2±24.6),低于感染组和健康对照组(平均±SD: 84.6±12、92.8±9.6);F = 39.03;P值= 0.001)。结论:哮喘对儿童HRQoL有显著的不良影响,EQ-5D-Y问卷可作为衡量儿童生活质量的有效工具。
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引用次数: 2
Interferon gamma: is it a co-player in the pathogenesis of idiopathic nephrotic syndrome? 干扰素γ:它是特发性肾病综合征发病机制的共同参与者吗?
IF 0.3 Pub Date : 2020-04-01 DOI: 10.21608/ejpa.2020.81768
A. Hassan, Ihab Z. El-Hakim, N. Amr, D. El-Ghoneimy, D. Soliman, D. Sallam
Introduction: Idiopathic nephrotic syndrome (INS), the most common form of NS in childhood, was considered 4 decades ago as a systemic disorder of T cells, mediated through its released cytokines. To date, the exact incriminated cytokine or immunological mediator is not properly defined. Interferon-gamma (IFN-gamma), a pro-inflammatory cytokine, is thought to have a role in the provocation of the T cell-mediated INS relapse, through the promotion of T helper1 (Th1) differentiation and suppression of regulatory T cells (Treg). Aim of the study: To evaluate the immunopathogenic role of IFN-gamma in children with steroid-sensitive idiopathic nephrotic syndrome (SSNS) through monitoring the changes in its levels with disease course. Methods: This study included twenty-five newly diagnosed children with SSINS. They were all given full dose prednisolone, evaluated at initial diagnosis and at full remission as regards the serum level of IFN-gamma. Results: Serum levels of IFN-gamma were lowermost at the time of diagnosis and increased with remission on corticosteroids. Conclusions: This study points to a role for the lower serum IFN-gamma at diagnosis, in the immunopathogenesis of INS than at remission and the rise in its serum level might be a marker of remission induction, however, this awaits confirmation in larger-scale studies. Studies on renal biopsy specimens are needed to determine the exact renal in situ levels and effects of IFN-gamma
特发性肾病综合征(Idiopathic nephrotic syndrome, INS)是儿童期最常见的一种肾病,40年前被认为是一种通过释放的细胞因子介导的T细胞全身性疾病。迄今为止,确切的相关细胞因子或免疫介质尚未得到适当的定义。干扰素- γ (ifn - γ)是一种促炎细胞因子,被认为通过促进T辅助细胞1 (Th1)分化和抑制调节性T细胞(Treg),在T细胞介导的INS复发中发挥作用。研究目的:通过监测ifn - γ在类固醇敏感型特发性肾病综合征(SSNS)患儿病程中的水平变化,评价其免疫致病作用。方法:本研究纳入25例新诊断的SSINS患儿。他们都给予全剂量强的松龙,在初始诊断和完全缓解时评估血清ifn - γ水平。结果:血清ifn - γ水平在诊断时最低,随着皮质类固醇治疗的缓解而升高。结论:本研究指出,诊断时血清ifn - γ低于缓解时血清ifn - γ在INS免疫发病机制中的作用,血清ifn - γ的升高可能是诱导缓解的标志,然而,这有待于更大规模的研究证实。需要对肾活检标本进行研究,以确定确切的肾原位水平和ifn - γ的影响
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引用次数: 0
Elevated serum KL-6 in pediatric asthma exacerbation: a proof of alveolar injury 儿童哮喘加重时血清KL-6升高:肺泡损伤的证据
IF 0.3 Pub Date : 2020-04-01 DOI: 10.21608/ejpa.2020.81767
I. Draz, Iman A Shaheen, E. Youssef
Background: Asthma is one of the most popular chronic diseases in children. It is defined as a complicated inflammatory disorder in which the patient suffers from chronic and persistent inflammation of the airways. The sialylated glycoprotein Krebs von den Lungen-6 (KL-6), one of the lung epithelium-specific proteins, has been recognized as a significant biomarker which directly associates with interstitial lung disease (ILD) pathogenesis, indicating the extent of damage and regeneration of type II pneumocytes. Objective: the aim of this study is to investigate the degree of alveolar damage in asthmatic children with acute exacerbation as reflected by serum KL-6 levels. Methods: This cross-sectional controlled study included 50 patients with acute asthma exacerbation diagnosed as per the GINA guidelines definition and 50 age- and sex-matched healthy children as controls. Spirometry was done for all participants. Serum KL-6 level was estimated by Enzyme Linked Immunosorbent Assay (ELISA), and total serum IgE level was measured via the electrochemiluminescence technology. Results: The asthma patients included 35 (70%) males and 15 (30%) females with mean age of 10.76 ±1.9 years. Forty-seven patients (94%) had a positive family history of bronchial asthma and 32 (64%) had other atopic manifestations The mean serum KL-6 level in patients was more than double the mean level of the control group (115.79 vs 55.64). No significant relation was observed between KL-6 serum level and age, family history of asthma, seasonal variation, or atopic manifestation among the cases. Serum total IgE levels were significantly higher in cases compared to controls (P<0.05). Conclusion: Serum KL-6 levels in pediatric asthma patients may be a useful diagnostic tool for detecting and monitoring the severity of airway inflammation. The use of serum KL-6 alone may help to differentiate between asthmatic patients in exacerbation and healthy controls.
背景:哮喘是儿童最常见的慢性疾病之一。它被定义为一种复杂的炎症性疾病,患者患有慢性和持续的气道炎症。唾液化糖蛋白Krebs von den Lungen-6 (KL-6)是肺上皮特异性蛋白之一,已被认为是与间质性肺疾病(ILD)发病机制直接相关的重要生物标志物,表明II型肺细胞的损伤程度和再生程度。目的:本研究的目的是通过血清KL-6水平反映哮喘儿童急性加重期肺泡损伤程度。方法:本横断面对照研究纳入50例根据GINA指南定义诊断的急性哮喘加重患者和50例年龄和性别匹配的健康儿童作为对照。对所有参与者进行肺活量测定。采用酶联免疫吸附试验(ELISA)测定血清KL-6水平,电化学发光技术测定血清总IgE水平。结果:哮喘患者男性35例(70%),女性15例(30%),平均年龄10.76±1.9岁。47例(94%)患者有支气管哮喘家族史,32例(64%)患者有其他特应性表现,患者平均血清KL-6水平是对照组平均水平的2倍以上(115.79 vs 55.64)。KL-6水平与年龄、哮喘家族史、季节变化、特应性表现无显著相关性。患者血清总IgE水平显著高于对照组(P<0.05)。结论:儿童哮喘患者血清KL-6水平可作为检测和监测气道炎症严重程度的有效诊断工具。单独使用血清KL-6可能有助于区分哮喘患者的恶化和健康对照。
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引用次数: 1
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Egyptian Journal of Pediatric Allergy and Immunology
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